                         SEQUENCE LISTING

<110>  VASCULONICS LLC
 
<120>  MODIFIED DDAH POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCING
        MOIETY, IMPROVED PHARMACOLOGY AND THEIR USES

<130>  10877-003WO1

<140>  PCT/US2018/044627
<141>  2018-07-31

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  285
<212>  PRT
<213>  Human

<400>  1

Met Ala Gly Leu Gly His Pro Ala Ala Phe Gly Arg Ala Thr His Ala 
1               5                   10                  15      


Val Val Arg Ala Leu Pro Glu Ser Leu Gly Gln His Ala Leu Arg Ser 
            20                  25                  30          


Ala Lys Gly Glu Glu Val Asp Val Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Glu 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Ala Asp Gly Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Ile Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Asn Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met 
                245                 250                 255     


Leu Ile Pro Val Ser Met Ser Glu Leu Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Cys Ser Val Leu Ile Asn Lys Lys Val Asp Ser 
        275                 280                 285 


<210>  2
<211>  285
<212>  PRT
<213>  Human

<400>  2

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Ile Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Ser Gly Pro Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Asp Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Val Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ala Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Leu Pro Gly Val Pro Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Ser 
        275                 280                 285 


<210>  3
<211>  1633
<212>  DNA
<213>  Human


<220>
<221>  misc_feature
<222>  (1485)..(1485)
<223>  n is a, c, g, or t

<400>  3
aacttaatgt ttttgcattg gactttgagt taagattatt ttttaaatcc tgaggactag       60

cattaattga cagctgaccc aggtgctaca cagaagtgga ttcagtgaat ctaggaagac      120

agcagcagac aggattccag gaaccagtgt ttgatgaagc taggactgag gagcaagcga      180

gcaagcagca gttcgtggaa tcctgtctgc tgctgtcttc ctggtttagg agccgacggg      240

cgctcgcagg ctcagcgcgc gctgcccgcg gcaggacccg gccgcctccg ccgccgccgc      300

cgcccctaag cctcccgaag ccatggccgg gctcggccac cccgccgcct tcggccgggc      360

cacccacgcc gtggtgcggg cgctacccga gtcgctcggc cagcacgcgc tgagaagcgc      420

caagggcgag gaggtggacg tcgcccgcgc ggaacggcag caccagctct acgtgggcgt      480

gctgggcagc aagctggggc tgcaggtggt ggagctgccg gccgacgaga gccttccgga      540

ctgcgtcttc gtggaggacg tggccgtggt gtgcgaggag acggccctca tcacccgacc      600

cggggcgccg agccggagga aggaggttga catgatgaaa gaagcattag aaaaacttca      660

gctcaatata gtagagatga aagatgaaaa tgcaacttta gatggcggag atgttttatt      720

cacaggcaga gaattttttg tgggcctttc caaaaggaca aatcaacgag gtgctgaaat      780

cttggctgat acttttaagg actatgcagt ctccacagtg ccagtggcag atgggttgca      840

tttgaagagt ttctgcagca tggctgggcc taacctgatc gcaattgggt ctagtgaatc      900

tgcacagaag gcccttaaga tcatgcaaca gatgagtgac caccgctacg acaaactcac      960

tgtgcctgat gacatagcag caaactgtat atatctaaat atccccaaca aagggcacgt     1020

cttgctgcac cgaaccccgg aagagtatcc agaaagtgca aaggtttatg agaaactgaa     1080

ggaccatatg ctgatccccg tgagcatgtc tgaactggaa aaggtggatg ggctgctcac     1140

ctgctgctca gttttaatta acaagaaagt agactcctga gctgcagagt cccccccggt     1200

agccggcaag accgcacagg caaggccgat gactctgtgc ccactcctgt tgttttcctt     1260

gacaatctac tgtgccactg tgctactaac tcttgtttac aaaatttgat tctaagttga     1320

attgcttcat tcaacacccc caccctccct ccccrcgagg tggtacctaa gctgtggatt     1380

tgctaaatga attaagcaac ctagaagata cagagctaat gaattatcaa aatgtgatta     1440

atcccagtaa ggaaacactc atttagtgtc tgtatttttg gtgtnaaaat tatttagttg     1500

ccagtatatt ctgaagaatg tcttcttgat cagtcagata agcttgcttt tttttttttt     1560

ttttcatgaa tcatgtttgg ttcctgtgaa agtccctggt ccagggatcc tcctcctttc     1620

tcttttactt ctg                                                        1633


<210>  4
<211>  1351
<212>  DNA
<213>  Human

<400>  4
ccgcttagac aatgccccgg agccgccaga ccgtcgcgcc cctgccccat cgtagtatat       60

gagctcgcct acacaaggac ccccgctaaa agccagagct cccagtcccc gaggcttgaa      120

gacggggact cccttctcca ccaactctgt cctcgggggg tggggcccca gccgagatca      180

cagcgcgaca ggagtggggg tggccgctgg agacaggtga agaaacaaga aaactaagaa      240

atccgagcgg ttggaggggg agtctgtgtg gatgggatgg ggacgccggg ggaggggctg      300

ggccgctgct cccatgccct gatccgggga gtcccagaga gcctggcgtc gggggaaggt      360

gcgggggctg gccttcccgc tctggatctg gccaaagctc aaagggagca cggggtgctg      420

ggaggtaaac tgaggcaacg actggggcta cagctgctag aactgccacc tgaggagtca      480

ttgccgctgg gaccgctgct tggcgacacg gccgtgatcc aaggggacac ggccctaatc      540

acgcggccct ggagccccgc tcgtaggcca gaggtcgatg gagtccgcaa agccctgcaa      600

gacctggggc tccgaattgt ggaaatagga gacgagaacg cgacgctgga tggcactgac      660

gttctcttca ccggccggga gtttttcgta ggcctctcca aatggaccaa tcaccgagga      720

gctgagatcg tggcggacac gttccgggac ttcgccgtct ccactgtgcc agtctcgggt      780

ccctcccacc tgcgcggtct ctgcggcatg gggggacctc gcactgttgt ggcaggcagc      840

agcgacgctg cccaaaaggc tgtccgggca atggcagtgc tgacagatca cccatatgcc      900

tccctgaccc tcccagatga cgcagctgct gactgcctct ttcttcgtcc tgggttgcct      960

ggtgtgcccc ctttcctcct gcaccgtgga ggtggggatc tgcccaacag ccaggaggca     1020

ctgcagaagc tctctgatgt caccctggta cctgtgtcct gctcagaact ggagaaggct     1080

ggcgccgggc tcagctccct ctgcttggtg ctcagcacac gcccccacag ctgagggcct     1140

ggccttgggg tactgctggc caggggtagg atagtatagg aagtagaagg ggaaggaggg     1200

ttagatagag aatgctgaat aggcagtagt tgggagagag cctcaatatt gggggagggg     1260

agagtgtagg gaaaaggatc cactgggtga atcctccctc tcagaaccaa taaaatagaa     1320

ttgacctttt aaaaaaaaaa aaaaaaaaaa a                                    1351


<210>  5
<211>  285
<212>  PRT
<213>  Human

<400>  5

Met Ala Ser Leu Gly His Pro Ala Thr Phe Gly Arg Ala Thr His Val 
1               5                   10                  15      


Val Val Arg Ala Leu Pro Glu Ser Leu Ala Gln Gln Ala Leu Arg Arg 
            20                  25                  30          


Thr Lys Gly Asp Glu Val Asp Phe Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Gln 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Ala Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Val Asp Ala Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Thr Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Ser Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met 
                245                 250                 255     


Leu Ile Pro Val Ser Asn Ser Glu Leu Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Ser Ser Val Leu Ile Asn Lys Lys Val Asp Ser 
        275                 280                 285 


<210>  6
<211>  285
<212>  PRT
<213>  Bovine

<400>  6

Met Ala Ser Leu Gly His Pro Ala Thr Phe Gly Arg Ala Thr His Val 
1               5                   10                  15      


Val Val Arg Ala Leu Pro Glu Ser Leu Ala Gln Gln Ala Leu Arg Arg 
            20                  25                  30          


Thr Lys Gly Asp Glu Val Asp Phe Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Gln 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Ala Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Val Asp Ala Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Thr Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Ser Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met 
                245                 250                 255     


Leu Ile Pro Val Ser Asn Ser Glu Leu Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Ser Ser Val Leu Ile Asn Lys Lys Val Asp Ser 
        275                 280                 285 


<210>  7
<211>  285
<212>  PRT
<213>  Bovine

<400>  7

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Val Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Met Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Thr Ser Thr Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Glu Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Val Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ala Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Gln Pro Gly Leu Pro Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Asn 
        275                 280                 285 


<210>  8
<211>  858
<212>  DNA
<213>  Bovine

<400>  8
atggcttctc tcggccaccc agccaccttt ggccgggcca cccatgtcgt ggtacgggcg       60

ctgcccgagt ccctcgccca acaggcgctg aggcgcacca agggcgacga ggtggatttc      120

gcccgcgctg agcggcagca ccagctctac gtgggcgtgc tgggcagtaa actggggctg      180

caggtggtgc agctgcccgc cgacgagagc ctcccagact gcgtgttcgt ggaggacgtg      240

gccgtggtgt gcgaggagac ggccctgatc acccgccccg gggcgccgag ccggaggaag      300

gaggctgaca tgatgaaaga agcactagaa aaacttcagc tcaacatagt agagatgaaa      360

gatgaaaatg caactttaga tggtggagat gtcttattca caggcagaga attttttgtg      420

ggcctttcca aaaggacaaa tcaacgaggt gcggaaatct tggctgatac ttttaaggac      480

tatgcggtct ccacggtccc tgtggtggat gctttgcact tgaagagttt ctgcagcatg      540

gctgggccta acctaatcgc tattggatcc agtgaatctg cacagaaggc cctcaagatc      600

atgcaacaga tgagtgatca tcgctacgac aaactcacag tgcctgatga cacggccgca      660

aactgcatat acctgaatat ccccagcaaa ggccacgtct tgctgcaccg aaccccagaa      720

gagtacccag agagtgcaaa ggtttatgaa aagctgaagg accatatgct gatccccgtg      780

agcaattctg aactggaaaa ggtggacggg ctgctcacct gcagctcggt tttaattaac      840

aagaaagtag actcctga                                                    858


<210>  9
<211>  285
<212>  PRT
<213>  Murine

<400>  9

Met Ala Gly Leu Gly His Pro Ser Ala Phe Gly Arg Ala Thr His Ala 
1               5                   10                  15      


Val Val Arg Ala Pro Pro Glu Ser Leu Cys Arg His Ala Leu Arg Arg 
            20                  25                  30          


Ser Gln Gly Glu Glu Val Asp Phe Ala Arg Ala Glu Arg Gln His Glu 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Gln 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Ala Asp Ser Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Met Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Ser Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Leu 
                245                 250                 255     


Leu Ile Pro Val Ser Asn Ser Glu Met Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Cys Ser Val Phe Ile Asn Lys Lys Ile Asp Ser 
        275                 280                 285 


<210>  10
<211>  285
<212>  PRT
<213>  Murine

<400>  10

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Met Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Ser Gly Ser Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Glu Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Ala Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ser Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Leu Pro Gly Ala Thr Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Cys 
        275                 280                 285 


<210>  11
<211>  285
<212>  PRT
<213>  Rat

<400>  11

Met Ala Gly Leu Ser His Pro Ser Val Phe Gly Arg Ala Thr His Ala 
1               5                   10                  15      


Val Val Arg Ala Pro Pro Glu Ser Leu Cys Arg His Ala Leu Arg Arg 
            20                  25                  30          


Ser Gln Gly Glu Glu Val Asp Phe Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Gln 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Ala Asp Ser Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Met Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Ser Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Leu 
                245                 250                 255     


Leu Ile Pro Val Ser Asn Ser Glu Met Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Cys Ser Val Phe Ile Asn Lys Lys Thr Asp Ser 
        275                 280                 285 


<210>  12
<211>  285
<212>  PRT
<213>  Rat

<400>  12

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Met Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Ser Gly Ala Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Glu Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Ala Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ser Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Leu Pro Gly Thr Thr Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Val Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Cys 
        275                 280                 285 


<210>  13
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacterial

<400>  13

Met Phe Lys His Ile Ile Ala Arg Thr Pro Ala Arg Ser Leu Val Asp 
1               5                   10                  15      


Gly Leu Thr Ser Ser His Leu Gly Lys Pro Asp Tyr Ala Lys Ala Leu 
            20                  25                  30          


Glu Gln His Asn Ala Tyr Ile Arg Ala Leu Gln Thr Cys Asp Val Asp 
        35                  40                  45              


Ile Thr Leu Leu Pro Pro Asp Glu Arg Phe Pro Asp Ser Val Phe Val 
    50                  55                  60                  


Glu Asp Pro Val Leu Cys Thr Ser Arg Cys Ala Ile Ile Thr Arg Pro 
65                  70                  75                  80  


Gly Ala Glu Ser Arg Arg Gly Glu Thr Glu Ile Ile Glu Glu Thr Val 
                85                  90                  95      


Gln Arg Phe Tyr Pro Gly Lys Val Glu Arg Ile Glu Ala Pro Gly Thr 
            100                 105                 110         


Val Glu Ala Gly Asp Ile Met Met Val Gly Asp His Phe Tyr Ile Gly 
        115                 120                 125             


Glu Ser Ala Arg Thr Asn Ala Glu Gly Ala Arg Gln Met Ile Ala Ile 
    130                 135                 140                 


Leu Glu Lys His Gly Leu Ser Gly Ser Val Val Arg Leu Glu Lys Val 
145                 150                 155                 160 


Leu His Leu Lys Thr Gly Leu Ala Tyr Leu Glu His Asn Asn Leu Leu 
                165                 170                 175     


Ala Ala Gly Glu Phe Val Ser Lys Pro Glu Phe Gln Asp Phe Asn Ile 
            180                 185                 190         


Ile Glu Ile Pro Glu Glu Glu Ser Tyr Ala Ala Asn Cys Ile Trp Val 
        195                 200                 205             


Asn Glu Arg Val Ile Met Pro Ala Gly Tyr Pro Arg Thr Arg Glu Lys 
    210                 215                 220                 


Ile Ala Arg Leu Gly Tyr Arg Val Ile Glu Val Asp Thr Ser Glu Tyr 
225                 230                 235                 240 


Arg Lys Ile Asp Gly Gly Val Ser Cys Met Ser Leu Arg Phe 
                245                 250                 


<210>  14
<211>  285
<212>  PRT
<213>  Rhesus Monkey

<400>  14

Met Ala Gly Leu Gly His Pro Ala Ala Phe Gly Arg Ala Thr His Ala 
1               5                   10                  15      


Val Val Arg Ala Leu Pro Glu Ser Leu Gly Gln His Ala Leu Arg Ser 
            20                  25                  30          


Ala Lys Gly Glu Glu Val Asp Val Ala Arg Ala Glu Arg Gln His Gln 
        35                  40                  45              


Leu Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Glu 
    50                  55                  60                  


Leu Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val 
65                  70                  75                  80  


Ala Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro 
                85                  90                  95      


Ser Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu 
            100                 105                 110         


Gln Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly 
        115                 120                 125             


Gly Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys 
    130                 135                 140                 


Arg Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp 
145                 150                 155                 160 


Tyr Ala Val Ser Thr Val Pro Val Ala Asp Gly Leu His Leu Lys Ser 
                165                 170                 175     


Phe Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu 
            180                 185                 190         


Ser Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg 
        195                 200                 205             


Tyr Asp Lys Leu Thr Val Pro Asp Asp Ile Ala Ala Asn Cys Ile Tyr 
    210                 215                 220                 


Leu Asn Ile Pro Asn Lys Gly His Val Leu Leu His Arg Thr Pro Glu 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met 
                245                 250                 255     


Leu Ile Pro Val Ser Met Ser Glu Leu Glu Lys Val Asp Gly Leu Leu 
            260                 265                 270         


Thr Cys Cys Ser Val Leu Ile Asn Lys Lys Val Asp Ser 
        275                 280                 285 


