                         SEQUENCE LISTING

<110>  The Penn State Research Foundation
 
<120>  ULTRASOUND SENSITIVE PEPTIDE NANOPARTICLES FOR SPATIALLY RESOLVED
        MOLECULE DELIVERY

<130>  36PST94052WO

<150>  62/538,116
<151>  2017-07-28

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  1

Arg Gly Arg Arg 
1               


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  2

Arg Gly Arg Arg Ser 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  3

Tyr Gln Leu Asp Val 
1               5   


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  4

Val Gly Val Ala 
1               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  5

Gly His Gly Lys His Lys Asn Lys 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  6

Cys Arg Gly Asp Lys Gly Pro Asp Cys 
1               5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  7

Cys Lys Gly Ala Lys Ala Arg 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  8

Cys Arg Val Ser Arg Gln Asn Lys Cys 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  9

Cys Gly Gly Glu Arg Gly Lys Ser Cys 
1               5                   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  10

Cys Arg Ser Arg Lys Gly 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  11

Cys Lys Ala Ala Lys Asn 
1               5       


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  12

Cys Arg Gly Arg Arg Ser Thr 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  13

Cys Glu Tyr Gln Leu Asp Val Glu 
1               5               


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  14

Thr Val Arg Thr Ser Ala Asp 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  15

Pro Ile Glu Asp Arg Pro Met 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  16

Ala Leu Arg Asp Arg Pro Met 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  17

Pro Glu Lys Phe Arg Pro Met 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  18

Ile Lys Val Gly Lys Leu Gln 
1               5           


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  19

Ser Val Ser Val Gly Met Lys Pro Ser Pro Arg Pro 
1               5                   10          


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  20

Val Pro Glu Gln Arg Pro Met 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  21

Cys Ala Lys Ile Asp Pro Glu Leu Cys 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  22

Cys Ser Asn Ile Asp Ala Arg Ala Cys 
1               5                   


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  23

Arg Leu Gln Leu Lys Leu 
1               5       


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  24

Pro Met Met Arg Gln Arg Pro Met 
1               5               


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  25

Ala Lys Ala Thr Cys Pro Ala 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  26

Gln Pro Pro Met Glu Tyr Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  27

Ser Ile Ser Ser Leu Thr Asp 
1               5           


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  28

Phe Arg Val Gly Val Ala Asp Val 
1               5               


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  29

Cys Asn Gly Arg Cys Val Ser Gly Cys Ala Gly Arg Cys 
1               5                   10              


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  30

Asn Trp Gly Asp Arg Ile Leu 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  31

Cys Val Ser Asn Pro Arg Trp Lys Cys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  32

Cys Asp Cys Arg Gly Asp Cys Phe Cys 
1               5                   


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  33

Tyr Ser Ala Tyr Pro Asp Ser Val Pro Met Met Ser 
1               5                   10          


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  34

Pro Leu Ala Ser Arg Pro Met 
1               5           


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  35

Lys Gly Arg Gly Asp 
1               5   


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  36

Arg Gly Asp Ser 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  37

Gly Arg Gly Asp 
1               


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  38

Gly Arg Gly Asp Ser 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  39

Gly Arg Gly Asp Ser Pro 
1               5       


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  40

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  41

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including an RGD targeting agent

<400>  42

Gly Arg Gly Asp Thr Pro 
1               5       


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  43

Cys Arg Lys Arg Leu Asp Arg Asn Cys 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  44

Cys Arg Lys Arg Leu Asp Arg Asn Cys 
1               5                   


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting motif

<400>  45

Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu Gln 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cross-linking motif

<400>  46

Gly Gly Gly Cys Cys Gly Gly 
1               5           


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amphiphilic peptide


<220>
<221>  X
<222>  (1)..(3)
<223>  Each X is pentafluoro phenylalanine 
       (2,3,4,5,6-pentafluoro-L-phenylalanine).

<400>  47

Xaa Xaa Xaa Gly Gly Gly Cys Cys Gly Gly Lys Gly Arg Gly Asp 
1               5                   10                  15  


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminally amidated hydrophilic amino acid sequence which 
       contains targeting motif RGD


<220>
<221>  AMIDATION
<222>  (5)..(5)

<400>  48

Lys Gly Arg Gly Asp 
1               5   


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amphiphilic peptide


<220>
<221>  X
<222>  (1)..(3)
<223>  Each X is pentafluoro phenylalanine 
       (2,3,4,5,6-pentafluoro-L-phenylalanine).

<220>
<221>  Amidation
<222>  (15)..(15)

<400>  49

Xaa Xaa Xaa Gly Gly Gly Cys Cys Gly Gly Lys Gly Arg Gly Asp 
1               5                   10                  15  


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hydrophilic amino acid sequence including a targeting agent

<400>  50

Cys Arg Gly Arg Arg Thr 
1               5       


