                         SEQUENCE LISTING

<110>  UNIVERSITY OF SOUTHERN CALIFORNIA
       Liman, Emily
       Tu, Yu-Hsiang
 
<120>  OTOPETRIN PROTON CHANNELS AS TARGETS FOR PHARMACEUTICAL DISCOVERY

<130>  043871-0459804

<140>  To Be Assigned
<141>  2018-07-27

<150>  62/537,900
<151>  2017-07-27

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Glu Gly Leu Gly Ser Pro Ala Ser Pro Arg Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ser Val Ala Gly Ser Ser Gly Pro Ala Ala Cys Ser Pro Pro Ser 
            20                  25                  30          


Ser Ser Ala Pro Arg Ser Pro Glu Ser Pro Ala Pro Arg Arg Gly Gly 
        35                  40                  45              


Val Arg Ala Ser Val Pro Gln Lys Leu Ala Glu Met Leu Ser Ser Gln 
    50                  55                  60                  


Tyr Gly Leu Ile Val Phe Val Ala Gly Leu Leu Leu Leu Leu Ala Trp 
65                  70                  75                  80  


Ala Val His Ala Ala Gly Val Ser Lys Ser Asp Leu Leu Cys Phe Leu 
                85                  90                  95      


Thr Ala Leu Met Leu Leu Gln Leu Leu Trp Met Leu Trp Tyr Val Gly 
            100                 105                 110         


Arg Ser Ser Ala His Arg Arg Leu Phe Arg Leu Lys Asp Thr His Ala 
        115                 120                 125             


Gly Ala Gly Trp Leu Arg Gly Ser Ile Thr Leu Phe Ala Val Ile Thr 
    130                 135                 140                 


Val Ile Leu Gly Cys Leu Lys Ile Gly Tyr Phe Ile Gly Phe Ser Glu 
145                 150                 155                 160 


Cys Leu Ser Ala Thr Glu Gly Val Phe Pro Val Thr His Ser Val His 
                165                 170                 175     


Thr Leu Leu Gln Val Tyr Phe Leu Trp Gly His Ala Lys Asp Ile Ile 
            180                 185                 190         


Gln Ser Phe Lys Thr Leu Glu Arg Phe Gly Val Ile His Ser Val Phe 
        195                 200                 205             


Thr Asn Leu Leu Leu Trp Ala Asn Gly Val Leu Asn Glu Ser Lys His 
    210                 215                 220                 


Gln Leu Asn Glu His Lys Glu Arg Leu Ile Thr Leu Gly Phe Gly Asn 
225                 230                 235                 240 


Ile Thr Thr Val Leu Asp Asp His Thr Pro Gln Cys Asn Cys Thr Pro 
                245                 250                 255     


Pro Thr Leu Cys Thr Ala Ile Ser His Gly Ile Tyr Tyr Leu Tyr Pro 
            260                 265                 270         


Phe Asn Ile Glu Tyr Gln Ile Leu Ala Ser Thr Met Leu Tyr Val Leu 
        275                 280                 285             


Trp Lys Asn Ile Gly Arg Lys Val Asp Ser His Gln His Gln Lys Met 
    290                 295                 300                 


Gln Phe Lys Ser Asp Gly Val Met Val Gly Ala Val Leu Gly Leu Thr 
305                 310                 315                 320 


Val Leu Ala Ala Thr Ile Ala Val Val Val Val Tyr Leu Ile His Ile 
                325                 330                 335     


Gly Arg Ser Lys Thr Lys Ser Glu Ser Ala Leu Ile Met Phe Tyr Leu 
            340                 345                 350         


Tyr Ala Ile Thr Leu Leu Met Leu Met Gly Ala Ala Gly Leu Ala Gly 
        355                 360                 365             


Ile Arg Ile Tyr Arg Ile Asp Glu Lys Ser Leu Asp Glu Ser Lys Asn 
    370                 375                 380                 


Pro Ala Arg Lys Leu Asp Ser Asp Leu Leu Val Gly Thr Ala Ser Gly 
385                 390                 395                 400 


Ser Trp Leu Ile Ser Trp Gly Ser Ile Leu Ala Ile Leu Cys Ala Glu 
                405                 410                 415     


Gly His Pro Arg Tyr Thr Trp Tyr Asn Leu Pro Tyr Ser Ile Leu Ala 
            420                 425                 430         


Ile Val Glu Lys Tyr Ile Gln Asn Leu Phe Ile Phe Glu Ser Ile His 
        435                 440                 445             


Arg Glu Pro Glu Lys Leu Ser Glu Asp Ile Gln Thr Leu Arg Val Val 
    450                 455                 460                 


Thr Val Cys Asn Gly Asn Thr Met Pro Leu Ala Ser Ser Cys Pro Lys 
465                 470                 475                 480 


Ser Gly Gly Val Ala Arg Asp Val Ala Pro Gln Gly Lys Asp Met Pro 
                485                 490                 495     


Pro Ala Ala Asn Gly Asn Val Cys Met Arg Glu Ser His Asp Lys Glu 
            500                 505                 510         


Glu Glu Lys Gln Glu Glu Ser Ser Trp Gly Gly Ser Pro Ser Pro Val 
        515                 520                 525             


Arg Leu Pro Arg Phe Leu Gln Gly Asn Ala Lys Arg Lys Val Leu Arg 
    530                 535                 540                 


Asn Ile Ala Ala Phe Leu Phe Leu Cys Asn Ile Ser Leu Trp Ile Pro 
545                 550                 555                 560 


Pro Ala Phe Gly Cys Arg Pro Glu Tyr Asp Asn Gly Leu Glu Glu Ile 
                565                 570                 575     


Val Phe Gly Phe Glu Pro Trp Ile Ile Val Val Asn Leu Ala Met Pro 
            580                 585                 590         


Phe Ser Ile Phe Tyr Arg Met His Ala Ala Ala Ser Leu Phe Glu Val 
        595                 600                 605             


Tyr Cys Lys Ile 
    610         


<210>  2
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Glu Glu Leu Ala Gln Gly Pro Lys Glu Ser Pro Pro Ala Pro 
1               5                   10                  15      


Arg Ala Gly Pro Arg Glu Val Trp Lys Lys Gly Gly Arg Leu Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Val Asn Val Leu Leu Leu Ala Cys Thr Leu Ile Ser 
        35                  40                  45              


Gly Gly Ala Phe Asn Lys Val Ala Val Tyr Asp Thr Asp Val Phe Ala 
    50                  55                  60                  


Leu Leu Thr Ala Met Met Leu Leu Ala Thr Leu Trp Ile Leu Phe Tyr 
65                  70                  75                  80  


Leu Leu Arg Thr Val Arg Cys Pro Cys Ala Val Pro Tyr Arg Asp Ala 
                85                  90                  95      


His Ala Gly Pro Ile Trp Leu Arg Gly Gly Leu Val Leu Phe Gly Ile 
            100                 105                 110         


Cys Thr Leu Ile Met Asp Val Phe Lys Thr Gly Tyr Tyr Ser Ser Phe 
        115                 120                 125             


Phe Glu Cys Gln Ser Ala Ile Lys Ile Leu His Pro Leu Ile Gln Ala 
    130                 135                 140                 


Val Phe Val Ile Ile Gln Thr Tyr Phe Leu Trp Val Ser Ala Lys Asp 
145                 150                 155                 160 


Cys Val His Val His Leu Asp Leu Thr Trp Cys Gly Leu Met Phe Thr 
                165                 170                 175     


Leu Thr Thr Asn Leu Ala Ile Trp Met Ala Ala Val Val Asp Glu Ser 
            180                 185                 190         


Val His Gln Ser His Ser Tyr Ser Ser Ser His Ser Asn Ala Ser His 
        195                 200                 205             


Ala Arg Leu Ile Ser Asp Gln His Ala Asp Asn Pro Val Gly Gly Asp 
    210                 215                 220                 


Ser Cys Leu Cys Ser Thr Ala Val Cys Gln Ile Phe Gln Gln Gly Tyr 
225                 230                 235                 240 


Phe Tyr Leu Tyr Pro Phe Asn Ile Glu Tyr Ser Leu Phe Ala Ser Thr 
                245                 250                 255     


Met Leu Tyr Val Met Trp Lys Asn Val Gly Arg Phe Leu Ala Ser Thr 
            260                 265                 270         


Pro Gly His Ser His Thr Pro Thr Pro Val Ser Leu Phe Arg Glu Thr 
        275                 280                 285             


Phe Phe Ala Gly Pro Val Leu Gly Leu Leu Leu Phe Val Val Gly Leu 
    290                 295                 300                 


Ala Val Phe Ile Ile Tyr Glu Val Gln Val Ser Gly Asp Gly Ser Arg 
305                 310                 315                 320 


Thr Arg Gln Ala Leu Val Ile Tyr Tyr Ser Phe Asn Ile Val Cys Leu 
                325                 330                 335     


Gly Leu Thr Thr Leu Val Ser Leu Ser Gly Ser Ile Ile Tyr Arg Phe 
            340                 345                 350         


Asp Arg Arg Ala Met Asp His His Lys Asn Pro Thr Arg Thr Leu Asp 
        355                 360                 365             


Val Ala Leu Leu Met Gly Ala Ala Leu Gly Gln Tyr Ala Ile Ser Tyr 
    370                 375                 380                 


Tyr Ser Ile Val Ala Val Val Ala Gly Thr Pro Gln Asp Leu Leu Ala 
385                 390                 395                 400 


Gly Leu Asn Leu Thr His Ala Leu Leu Met Ile Ala Gln His Thr Phe 
                405                 410                 415     


Gln Asn Met Phe Ile Ile Glu Ser Leu His Arg Gly Pro Pro Gly Ala 
            420                 425                 430         


Glu Pro His Ser Thr His Pro Lys Glu Pro Cys Gln Asp Leu Thr Phe 
        435                 440                 445             


Thr Asn Leu Asp Ala Leu His Thr Leu Ser Ala Cys Pro Pro Asn Pro 
    450                 455                 460                 


Gly Leu Val Ser Pro Ser Pro Ser Asp Gln Arg Glu Ala Val Ala Ile 
465                 470                 475                 480 


Val Ser Thr Pro Arg Ser Gln Trp Arg Arg Gln Cys Leu Lys Asp Ile 
                485                 490                 495     


Ser Leu Phe Leu Leu Leu Cys Asn Val Ile Leu Trp Ile Met Pro Ala 
            500                 505                 510         


Phe Gly Ala Arg Pro His Phe Ser Asn Thr Val Glu Val Asp Phe Tyr 
        515                 520                 525             


Gly Tyr Ser Leu Trp Ala Val Ile Val Asn Ile Cys Leu Pro Phe Gly 
    530                 535                 540                 


Ile Phe Tyr Arg Met His Ala Val Ser Ser Leu Leu Glu Val Tyr Val 
545                 550                 555                 560 


Leu Ser 
        


<210>  3
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Arg Gly Ala Arg Ala Ala Ala Ala Gln Ser Arg Trp Gly Arg 
1               5                   10                  15      


Ala Ser Arg Ala Ser Val Ser Pro Gly Arg Thr Ile Arg Ser Ala Pro 
            20                  25                  30          


Ala Val Gly Glu Ala Gln Glu Thr Glu Ala Ala Pro Glu Lys Glu Asn 
        35                  40                  45              


Arg Val Asp Val Gly Ala Glu Glu Arg Ala Ala Ala Thr Arg Pro Arg 
    50                  55                  60                  


Gln Lys Ser Trp Leu Val Arg His Phe Ser Leu Leu Leu Arg Arg Asp 
65                  70                  75                  80  


Arg Gln Ala Gln Lys Ala Gly Gln Leu Phe Ser Gly Leu Leu Ala Leu 
                85                  90                  95      


Asn Val Val Phe Leu Gly Gly Ala Phe Ile Cys Ser Met Ile Phe Asn 
            100                 105                 110         


Lys Val Ala Val Thr Leu Gly Asp Val Trp Ile Leu Leu Ala Thr Leu 
        115                 120                 125             


Lys Val Leu Ser Leu Leu Trp Leu Leu Tyr Tyr Val Ala Ser Thr Thr 
    130                 135                 140                 


Arg Arg Pro His Ala Val Leu Tyr Gln Asp Pro His Ala Gly Pro Leu 
145                 150                 155                 160 


Trp Val Arg Gly Ser Leu Val Leu Phe Gly Ser Cys Thr Phe Cys Leu 
                165                 170                 175     


Asn Ile Phe Arg Val Gly Tyr Asp Val Ser His Ile Arg Cys Lys Ser 
            180                 185                 190         


Gln Leu Asp Leu Val Phe Ser Val Ile Glu Met Val Phe Ile Gly Val 
        195                 200                 205             


Gln Thr Trp Val Leu Trp Lys His Cys Lys Asp Cys Val Arg Val Gln 
    210                 215                 220                 


Thr Asn Phe Thr Arg Cys Gly Leu Met Leu Thr Leu Ala Thr Asn Leu 
225                 230                 235                 240 


Leu Leu Trp Val Leu Ala Val Thr Asn Asp Ser Met His Arg Glu Ile 
                245                 250                 255     


Glu Ala Glu Leu Gly Ile Leu Met Glu Lys Ser Thr Gly Asn Glu Thr 
            260                 265                 270         


Asn Thr Cys Leu Cys Leu Asn Ala Thr Ala Cys Glu Ala Phe Arg Arg 
        275                 280                 285             


Gly Phe Leu Met Leu Tyr Pro Phe Ser Thr Glu Tyr Cys Leu Ile Cys 
    290                 295                 300                 


Cys Ala Val Leu Phe Val Met Trp Lys Asn Val Gly Arg His Val Ala 
305                 310                 315                 320 


Pro His Met Gly Ala His Pro Ala Thr Ala Pro Phe His Leu His Gly 
                325                 330                 335     


Ala Ile Phe Gly Pro Leu Leu Gly Leu Leu Val Leu Leu Ala Gly Val 
            340                 345                 350         


Cys Val Phe Val Leu Phe Gln Ile Glu Ala Ser Gly Pro Ala Ile Ala 
        355                 360                 365             


Cys Gln Tyr Phe Thr Leu Tyr Tyr Ala Phe Tyr Val Ala Val Leu Pro 
    370                 375                 380                 


Thr Met Ser Leu Ala Cys Leu Ala Gly Thr Ala Ile His Gly Leu Glu 
385                 390                 395                 400 


Glu Arg Glu Leu Asp Thr Val Lys Asn Pro Thr Arg Ser Leu Asp Val 
                405                 410                 415     


Val Leu Leu Met Gly Ala Ala Leu Gly Gln Met Gly Ile Ala Tyr Phe 
            420                 425                 430         


Ser Ile Val Ala Ile Val Ala Lys Arg Pro His Glu Leu Leu Asn Arg 
        435                 440                 445             


Leu Ile Leu Ala Tyr Ser Leu Leu Leu Ile Leu Gln His Ile Ala Gln 
    450                 455                 460                 


Asn Leu Phe Ile Ile Glu Gly Leu His Arg Arg Pro Leu Trp Glu Thr 
465                 470                 475                 480 


Val Pro Glu Gly Leu Ala Gly Lys Gln Glu Ala Glu Pro Pro Arg Arg 
                485                 490                 495     


Gly Ser Leu Leu Glu Leu Gly Gln Gly Leu Gln Arg Ala Ser Leu Ala 
            500                 505                 510         


Tyr Ile His Ser Tyr Ser His Leu Asn Trp Lys Arg Arg Ala Leu Lys 
        515                 520                 525             


Glu Ile Ser Leu Phe Leu Ile Leu Cys Asn Ile Thr Leu Trp Met Met 
    530                 535                 540                 


Pro Ala Phe Gly Ile His Pro Glu Phe Glu Asn Gly Leu Glu Lys Asp 
545                 550                 555                 560 


Phe Tyr Gly Tyr Gln Ile Trp Phe Ala Ile Val Asn Phe Gly Leu Pro 
                565                 570                 575     


Leu Gly Val Phe Tyr Arg Met His Ser Val Gly Gly Leu Val Glu Val 
            580                 585                 590         


Tyr Leu Gly Ala 
        595     


<210>  4
<211>  600
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Gly Gly Pro Gly Ala Pro Ser Ser Pro Ala Ala Ser Ser Gly 
1               5                   10                  15      


Ser Ser Arg Ala Ala Pro Ser Gly Ile Ala Ala Cys Pro Leu Ser Pro 
            20                  25                  30          


Pro Pro Leu Ala Arg Gly Ser Pro Gln Ala Ser Gly Pro Arg Arg Gly 
        35                  40                  45              


Ala Ser Val Pro Gln Lys Leu Ala Glu Thr Leu Ser Ser Gln Tyr Gly 
    50                  55                  60                  


Leu Asn Val Phe Val Ala Gly Leu Leu Phe Leu Leu Ala Trp Ala Val 
65                  70                  75                  80  


His Ala Thr Gly Val Gly Lys Ser Asp Leu Leu Cys Val Leu Thr Ala 
                85                  90                  95      


Leu Met Leu Leu Gln Leu Leu Trp Met Leu Trp Tyr Val Gly Arg Ser 
            100                 105                 110         


Tyr Met Gln Arg Arg Leu Ile Arg Pro Lys Asp Thr His Ala Gly Ala 
        115                 120                 125             


Arg Trp Leu Arg Gly Ser Ile Thr Leu Phe Ala Phe Ile Thr Val Val 
    130                 135                 140                 


Leu Gly Cys Leu Lys Val Ala Tyr Phe Ile Gly Phe Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Ala Thr Glu Gly Val Phe Pro Val Thr His Ala Val His Thr Leu 
                165                 170                 175     


Leu Gln Val Tyr Phe Leu Trp Gly His Ala Lys Asp Ile Ile Met Ser 
            180                 185                 190         


Phe Lys Thr Leu Glu Arg Phe Gly Val Ile His Ser Val Phe Thr Asn 
        195                 200                 205             


Leu Leu Leu Trp Ala Asn Ser Val Leu Asn Glu Ser Lys His Gln Leu 
    210                 215                 220                 


Asn Glu His Lys Glu Arg Leu Ile Thr Leu Gly Phe Gly Asn Ile Thr 
225                 230                 235                 240 


Ile Val Leu Asp Asp His Thr Pro Gln Cys Asn Cys Thr Pro Pro Ala 
                245                 250                 255     


Leu Cys Ser Ala Leu Ser His Gly Ile Tyr Tyr Leu Tyr Pro Phe Asn 
            260                 265                 270         


Ile Glu Tyr Gln Ile Leu Ala Ser Thr Met Leu Tyr Val Leu Trp Lys 
        275                 280                 285             


Asn Ile Gly Arg Arg Val Asp Ser Ser Gln His Gln Lys Met Gln Cys 
    290                 295                 300                 


Arg Phe Asp Gly Val Leu Val Gly Ser Val Leu Gly Leu Thr Val Leu 
305                 310                 315                 320 


Ala Ala Thr Ile Ala Val Val Val Val Tyr Met Ile His Ile Gly Arg 
                325                 330                 335     


Ser Lys Ser Lys Ser Glu Ser Ala Leu Ile Met Phe Tyr Leu Tyr Ala 
            340                 345                 350         


Ile Thr Val Leu Leu Leu Met Gly Ala Ala Gly Leu Val Gly Ser Trp 
        355                 360                 365             


Ile Tyr Arg Val Asp Glu Lys Ser Leu Asp Glu Ser Lys Asn Pro Ala 
    370                 375                 380                 


Arg Lys Leu Asp Val Asp Leu Leu Val Ala Thr Ala Ser Gly Ser Trp 
385                 390                 395                 400 


Leu Leu Ser Trp Gly Ser Ile Leu Ala Ile Ala Cys Ala Glu Thr Arg 
                405                 410                 415     


Pro Pro Tyr Thr Trp Tyr Asn Leu Pro Tyr Ser Val Leu Val Ile Val 
            420                 425                 430         


Glu Lys Tyr Val Gln Asn Ile Phe Ile Ile Glu Ser Val His Leu Glu 
        435                 440                 445             


Pro Glu Gly Val Pro Glu Asp Val Arg Thr Leu Arg Val Val Thr Val 
    450                 455                 460                 


Cys Ser Ser Glu Ala Ala Ala Leu Ala Ala Ser Thr Leu Gly Ser Gln 
465                 470                 475                 480 


Gly Met Ala Gln Asp Gly Ser Pro Ala Val Asn Gly Asn Leu Cys Leu 
                485                 490                 495     


Gln Gln Arg Cys Gly Lys Glu Asp Gln Glu Ser Gly Trp Glu Gly Ala 
            500                 505                 510         


Thr Gly Thr Thr Arg Cys Leu Asp Phe Leu Gln Gly Gly Met Lys Arg 
        515                 520                 525             


Arg Leu Leu Arg Asn Ile Thr Ala Phe Leu Phe Leu Cys Asn Ile Ser 
    530                 535                 540                 


Leu Trp Ile Pro Pro Ala Phe Gly Cys Arg Pro Glu Tyr Asp Asn Gly 
545                 550                 555                 560 


Leu Glu Glu Ile Val Phe Gly Phe Glu Pro Trp Ile Ile Val Val Asn 
                565                 570                 575     


Leu Ala Met Pro Phe Ser Ile Phe Tyr Arg Met His Ala Ala Ala Ala 
            580                 585                 590         


Leu Phe Glu Val Tyr Cys Lys Ile 
        595                 600 


<210>  5
<211>  563
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ser Glu Glu Leu Val Pro His Pro Asn Glu Ser Leu Pro Gly Pro 
1               5                   10                  15      


Arg Ala Ser Pro Arg Glu Val Trp Lys Lys Gly Gly Arg Leu Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Val Asn Val Leu Leu Leu Ala Cys Thr Leu Ile Ser 
        35                  40                  45              


Gly Gly Ala Phe Asn Lys Val Ala Val Tyr Asp Thr Asp Val Phe Ala 
    50                  55                  60                  


Leu Leu Thr Thr Met Met Leu Leu Ala Ala Leu Trp Ile Val Phe Tyr 
65                  70                  75                  80  


Leu Leu Arg Thr Ala Arg Cys Pro Asp Ala Val Pro Tyr Arg Asp Ala 
                85                  90                  95      


His Ala Gly Pro Ile Trp Leu Arg Gly Gly Leu Val Leu Phe Gly Ile 
            100                 105                 110         


Cys Thr Leu Val Met Asp Val Phe Lys Thr Gly Tyr Tyr Ser Ser Phe 
        115                 120                 125             


Phe Glu Cys Gln Ser Ala Ile Lys Ile Leu His Pro Ile Ile Gln Ala 
    130                 135                 140                 


Val Phe Val Ile Val Gln Thr Tyr Phe Leu Trp Ile Ser Ala Lys Asp 
145                 150                 155                 160 


Cys Ile His Thr His Leu Asp Leu Thr Arg Cys Gly Leu Met Phe Thr 
                165                 170                 175     


Leu Ala Thr Asn Leu Ala Ile Trp Met Ala Ala Val Val Asp Glu Ser 
            180                 185                 190         


Val His Gln Ala His Ser Tyr Ser Gly Ser His Gly Asn Thr Ser His 
        195                 200                 205             


Thr Arg Leu Asn Pro Asp Ser Lys Arg Ala Gly Gly Ala Ala Glu Glu 
    210                 215                 220                 


Asp Pro Cys Leu Cys Ser Thr Ala Ile Cys Gln Ile Phe Gln Gln Gly 
225                 230                 235                 240 


Tyr Phe Tyr Leu Tyr Pro Phe Asn Ile Glu Tyr Ser Leu Phe Ala Ser 
                245                 250                 255     


Thr Met Leu Tyr Val Met Trp Lys Asn Val Gly Arg Leu Leu Ala Ser 
            260                 265                 270         


Thr His Gly His Gly His Thr Pro Ser Arg Val Ser Leu Phe Arg Glu 
        275                 280                 285             


Thr Phe Phe Ala Gly Pro Val Leu Gly Leu Leu Leu Phe Val Val Gly 
    290                 295                 300                 


Leu Ala Val Phe Ile Leu Tyr Glu Val Gln Val Ser Gly Glu Arg Gly 
305                 310                 315                 320 


His Thr Arg Gln Ala Leu Val Ile Tyr Tyr Ser Phe Asn Ile Val Cys 
                325                 330                 335     


Leu Gly Leu Met Thr Leu Val Ser Leu Ser Gly Ser Val Ile Tyr Arg 
            340                 345                 350         


Phe Asp Arg Arg Ala Met Asp His His Lys Asn Pro Thr Arg Thr Leu 
        355                 360                 365             


Asp Val Ala Leu Leu Met Gly Ala Ala Leu Gly Gln Tyr Ala Ile Ser 
    370                 375                 380                 


Tyr Tyr Ser Ile Val Ala Val Val Val Gly Ser Pro Arg Asp Leu Gln 
385                 390                 395                 400 


Gly Ala Leu Asn Leu Ser His Ala Leu Leu Met Ile Ala Gln His Thr 
                405                 410                 415     


Phe Gln Asn Val Phe Ile Ile Glu Ser Leu His Arg Gly Pro Pro Gly 
            420                 425                 430         


Ala Glu Pro Arg Glu Met Pro Pro Lys Glu Pro Cys Gln Gly Ile Thr 
        435                 440                 445             


Phe Ala Asn Leu Asp Ala Ile Arg Thr Leu Pro Ser Cys Pro Pro Thr 
    450                 455                 460                 


Pro Arg Leu Val Ile Pro Asn Leu Glu Ser Pro Gln Glu Ala Val Ala 
465                 470                 475                 480 


Ile Ile Ser Ala Pro Arg Cys His Trp Arg Arg Arg Cys Leu Lys Asp 
                485                 490                 495     


Ile Ser Leu Phe Leu Leu Leu Cys Asn Val Ile Leu Trp Ile Met Pro 
            500                 505                 510         


Ala Phe Gly Ala Arg Pro His Phe Ser Asn Thr Val Glu Val Asp Phe 
        515                 520                 525             


Tyr Gly Tyr Ser Leu Trp Ala Ala Ile Val Asn Ile Cys Leu Pro Phe 
    530                 535                 540                 


Gly Ile Phe Tyr Arg Met His Ala Val Ser Ser Leu Leu Glu Val Tyr 
545                 550                 555                 560 


Val Leu Ser 
            


<210>  6
<211>  577
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Ser Gln Thr Ser Ala Pro Ala Glu Pro Ala Pro Met Pro Ser 
1               5                   10                  15      


Pro Glu Ala Lys Thr Thr Glu Gly Ala Ser Ser Tyr Asp Gln Ala Asp 
            20                  25                  30          


Met Glu Thr Lys His Ala Gly Ser Pro Cys Pro Pro Lys Gln Lys Ser 
        35                  40                  45              


Trp Leu Ala Arg His Phe Ser Leu Leu Leu Arg Arg Asp Arg Gln Ala 
    50                  55                  60                  


Gln Lys Ala Gly Gln Leu Phe Ser Gly Leu Leu Ala Leu Asn Val Val 
65                  70                  75                  80  


Phe Leu Gly Gly Ala Phe Ile Cys Ser Met Ile Phe Asn Lys Val Ser 
                85                  90                  95      


Val Thr Leu Gly Asp Val Trp Ile Leu Leu Ala Ala Leu Lys Val Leu 
            100                 105                 110         


Ser Leu Leu Trp Leu Leu Tyr Tyr Thr Val Gly Thr Thr Arg Lys Pro 
        115                 120                 125             


His Ala Val Leu Tyr Arg Asp Pro His Ala Gly Pro Ile Trp Val Arg 
    130                 135                 140                 


Gly Ser Leu Val Leu Phe Gly Ser Cys Thr Val Cys Leu Asn Ile Phe 
145                 150                 155                 160 


Arg Met Gly Tyr Asp Val Ser His Ile His Cys Lys Ser Glu Val Glu 
                165                 170                 175     


Leu Ile Phe Pro Ala Ile Glu Ile Val Phe Met Ile Ile Gln Thr Trp 
            180                 185                 190         


Val Leu Trp Arg His Cys Lys Asp Cys Val Gln Val Gln Thr Asn Phe 
        195                 200                 205             


Thr Arg Cys Gly Leu Met Leu Thr Leu Ala Thr Asn Leu Leu Met Trp 
    210                 215                 220                 


Val Leu Ala Val Thr Asn Asp Ser Met His Arg Glu Ile Glu Ala Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Met Glu Lys Phe Ser Gly Asn Gly Thr Asn Thr Cys 
                245                 250                 255     


Met Cys Leu Asn Thr Thr Val Cys Glu Val Phe Arg Lys Gly Tyr Leu 
            260                 265                 270         


Met Leu Tyr Pro Phe Ser Thr Glu Tyr Cys Leu Ile Cys Cys Ala Val 
        275                 280                 285             


Leu Phe Val Met Trp Lys Asn Val Ser Arg Ser Leu Ala Ala His Thr 
    290                 295                 300                 


Gly Ala His Pro Asn Arg Ser Pro Phe Arg Leu His Gly Thr Ile Phe 
305                 310                 315                 320 


Gly Pro Leu Leu Gly Leu Leu Ala Leu Val Ala Gly Val Cys Val Phe 
                325                 330                 335     


Val Leu Phe Gln Ile Glu Ala Ser Gly Pro Asp Ile Ala Arg Gln Tyr 
            340                 345                 350         


Phe Thr Leu Tyr Tyr Ala Phe Tyr Val Ala Val Leu Pro Thr Met Ser 
        355                 360                 365             


Leu Ala Cys Leu Ala Gly Thr Ala Ile His Gly Leu Glu Glu Arg Glu 
    370                 375                 380                 


Leu Asp Thr Leu Lys Asn Pro Thr Arg Ser Leu Asp Val Val Leu Leu 
385                 390                 395                 400 


Met Gly Ala Ala Leu Gly Gln Met Gly Ile Ala Tyr Phe Ser Ile Val 
                405                 410                 415     


Ala Ile Val Ala Thr Gln Pro His Glu Leu Leu Asn Gln Leu Ile Leu 
            420                 425                 430         


Ala Tyr Ser Leu Leu Leu Ile Leu Gln His Ile Thr Gln Asn Leu Phe 
        435                 440                 445             


Ile Ile Glu Gly Leu His Arg Arg Pro Leu Trp Glu Pro Ala Val Ser 
    450                 455                 460                 


Gly Val Met Glu Lys Gln Asp Val Glu Leu Pro Arg Arg Gly Ser Leu 
465                 470                 475                 480 


Arg Glu Leu Gly Gln Asp Leu Arg Arg Ala Ser Arg Ala Tyr Ile His 
                485                 490                 495     


Ser Phe Ser His Leu Asn Trp Lys Arg Arg Met Leu Lys Glu Ile Ser 
            500                 505                 510         


Leu Phe Leu Ile Leu Cys Asn Ile Thr Leu Trp Met Met Pro Ala Phe 
        515                 520                 525             


Gly Ile His Pro Glu Phe Glu Asn Gly Leu Glu Lys Asp Phe Tyr Gly 
    530                 535                 540                 


Tyr Arg Thr Trp Phe Thr Ile Val Asn Phe Gly Leu Pro Leu Gly Val 
545                 550                 555                 560 


Phe Tyr Arg Met His Ser Val Gly Gly Leu Val Glu Val Tyr Leu Gly 
                565                 570                 575     


Ala 
    


<210>  7
<211>  977
<212>  PRT
<213>  Drosophila

<400>  7

Met Gln Arg Cys Pro Tyr Ile His Glu Met Arg Glu Arg Leu Leu Asp 
1               5                   10                  15      


Gln Pro Arg Glu Thr Leu Gln Leu Glu Asn Met Glu Arg Ala Asn Leu 
            20                  25                  30          


Leu Asp Asn Arg Gln Ser Ala Ser Glu Ser Asn Gln Leu Gln Gly Asp 
        35                  40                  45              


Gly Tyr His Thr Ser Pro Ala His Gln Arg Thr Pro Leu Val Pro His 
    50                  55                  60                  


Asp Leu Gly Glu Asp Phe Asn Leu Asp Phe Asp Asp Asp Phe Pro Ile 
65                  70                  75                  80  


Asp Ala Arg Arg Pro Lys Asn Ala Asn Asp Ile His Pro Ala Val Leu 
                85                  90                  95      


Thr Arg Pro Gln Gln Arg Thr Ser Leu Phe Ile Val Thr Ser Leu Val 
            100                 105                 110         


Tyr Ala Ile Leu Leu Ile Val Val Cys Ile Ala Tyr Val Ile Ser Asp 
        115                 120                 125             


Val Thr Thr His Arg Leu Pro Val Leu Tyr Tyr Glu Thr Phe Phe Thr 
    130                 135                 140                 


Tyr Leu Tyr Gly Val Ser Ile Leu Phe Leu Leu Tyr Val Phe Cys Phe 
145                 150                 155                 160 


Leu Leu Gln Glu Ser Ser Cys Cys Asn Gly Gly Asn Gly Gly Ser Lys 
                165                 170                 175     


Pro Lys Pro Gln Pro Lys Glu Lys Lys Ser Lys Lys Ala Lys Asn Ala 
            180                 185                 190         


Asp Pro Ala Asp Ser Lys Asp Ala Lys Gly Ser Lys Asp Ser Gly Lys 
        195                 200                 205             


Ala Ala Lys Gly Ala Ala Tyr Gln His Thr Leu Ala Lys Phe Leu Glu 
    210                 215                 220                 


Ala Pro Val Asp Ala Glu Val Ala Val Thr Pro Lys Asn Val Arg Lys 
225                 230                 235                 240 


Arg Lys Thr Thr His Ser Asp Leu Thr His Gly Ser Phe Phe Leu Arg 
                245                 250                 255     


Val Gly Ala Ile Ala Phe Gly Leu Gly Ala Met Ile Tyr Ile Gly Leu 
            260                 265                 270         


Glu Phe Gly Ser Phe Phe Glu Ile Pro Phe Asp Ser Pro Cys His His 
        275                 280                 285             


Ile Leu Ile Gly Val Asn Pro Leu Leu Gln Met Ile Phe Thr Phe Met 
    290                 295                 300                 


Gln Met Tyr Phe Ile Phe Met Asn Ala Arg Thr Arg Pro Pro Phe Gln 
305                 310                 315                 320 


Leu Asn Ile His Arg Phe Lys Val Ile Ala Arg Phe Gly Leu Met His 
                325                 330                 335     


Val Val Ala Thr Asn Ile Cys Val Trp Ile Arg Thr Leu Val Lys Glu 
            340                 345                 350         


Ser Leu Leu Glu Ile Thr Ile Tyr His Gln Lys Asn Glu Pro Glu Ala 
        355                 360                 365             


Gly Ala Ser Ser Ile Ala His Ser Ile Arg Gln His Ala Leu Arg His 
    370                 375                 380                 


Ala Gly Thr Val Leu Arg Thr His Ala Gly Pro Asn Ser Glu Phe Glu 
385                 390                 395                 400 


Val Leu Asp Gly Glu Asp Ile Leu Pro Lys Asp Val Tyr Lys Ser Asp 
                405                 410                 415     


Asn Val Leu Ser Lys Leu Val Arg Asn Thr Val Asp Gly Ile Ser Lys 
            420                 425                 430         


Ser Leu Gly Met Gly Gly Asp Gln Ala Leu Asp Ser Ser Thr Thr Ser 
        435                 440                 445             


Ser Ser Thr Thr Thr Thr Thr Arg Ala Pro Phe Thr Thr Pro Asn Tyr 
    450                 455                 460                 


Gln Trp His Ser Thr Thr Met Ala Arg Lys Leu Lys Lys Phe Ile Thr 
465                 470                 475                 480 


Ser Ala Thr Thr Ala Ala Thr Thr Ala Ala Gly Ser Ser Ser Thr Ala 
                485                 490                 495     


Ser Ser Thr Thr Thr Ile Ser Pro Thr Ile Ser Ser Thr Thr Ile Pro 
            500                 505                 510         


Ser Thr Thr Ile Ser Ser Thr Thr Ile Ser Ser Ser Thr Thr Phe Ser 
        515                 520                 525             


Pro Phe Ser Pro Ser Thr Thr Thr Thr Thr Thr Thr Thr Ala Ala Ala 
    530                 535                 540                 


Leu Asn Leu Glu Thr Ser Gly Ser Glu Ser Pro Phe Gly Gly Leu Gln 
545                 550                 555                 560 


Arg Ile Leu Ser Ser Ala Ala Pro Pro Ser Leu Ala Pro Val Asp Gly 
                565                 570                 575     


Phe Gly Ser Ala Ser Ala Ala Thr Pro Thr Ser Gly Ser Gly Ala Gly 
            580                 585                 590         


Ser Phe Val Asp Ser Phe Leu Ala Ser Thr Leu Ser Pro Ala Ser Ser 
        595                 600                 605             


Thr Glu Gly Ser Ala Ser Ile Met Asn Asn Leu Phe Gly Gln Gly Pro 
    610                 615                 620                 


Met Glu Asn Ser Phe Gln Thr Tyr Thr Asp Leu Gly His Glu Glu Ala 
625                 630                 635                 640 


Thr Gly Leu Val Ser Phe Glu Asn Leu Glu Ser Leu Asp Asn Ile Tyr 
                645                 650                 655     


Pro Ala Ala Leu Ser Ser Asn Ile Gly Thr Leu Asn Ser Thr Ala Cys 
            660                 665                 670         


Gly Arg Ile Asp Ile Met Gly Thr Ile Val Tyr Asp Ser Ala Pro Tyr 
        675                 680                 685             


Leu Tyr Pro Phe Ile Ile Glu Tyr Ser Leu Ile Gly Ala Val Val Leu 
    690                 695                 700                 


Tyr Val Met Trp Lys His Ile Gly Arg Tyr Pro Gly Arg Met Asn Asp 
705                 710                 715                 720 


Glu Asp Leu Glu His Arg Leu Glu Val Met Leu Ser Arg Arg Ala Val 
                725                 730                 735     


Ala Met Ala Gln Gln Ala Arg Ser Gly Arg Val Asp Cys Val Gly Ser 
            740                 745                 750         


Ser Lys Gly Leu Phe Phe Gly Leu Leu Leu Leu Val Gly Ala Leu Ile 
        755                 760                 765             


Cys Leu Ile Leu Phe Phe Val Leu Val Arg His Gln Gln Phe Ser Leu 
    770                 775                 780                 


Leu Ala Ile Tyr Leu Ala Asp Ala Ser His Cys Ile Leu Met Ala Phe 
785                 790                 795                 800 


Ala Ile Leu Ala Ile Ile Val Gly Phe Ile Arg Val Lys Asn Leu Lys 
                805                 810                 815     


Phe Arg Cys Glu Glu Gln Ser Asn Leu Asn Asp Ile Leu Leu Arg Ile 
            820                 825                 830         


Ser Ala Phe Gly Leu Phe Thr Tyr Ser Val Phe Ser Ile Ile Ala Gly 
        835                 840                 845             


Ser Leu Lys Val Leu Glu Ser Glu Pro Ser Leu Leu Val Thr Thr Thr 
    850                 855                 860                 


Gly Gly Val Ala Val Phe Gln Val Ile Leu Gln Leu Leu Phe Ile Ala 
865                 870                 875                 880 


Asp Val Ser Arg Arg Arg Val His Leu Pro Glu His Asp Arg Ser Lys 
                885                 890                 895     


Pro Gly Arg Gln Ile Val Thr Phe Leu Leu Ile Cys Asn Val Ala Met 
            900                 905                 910         


Phe Ala Ile Tyr Thr Phe Glu Ala Gln Lys Val Phe Ala Asn Pro Val 
        915                 920                 925             


Ser Arg Tyr Val Gln Leu Glu Phe Tyr Gly Phe Val Pro Trp Ser Ile 
    930                 935                 940                 


Ile Gln Arg Ile Thr Leu Pro Leu Cys Ile Phe His Arg Phe His Ser 
945                 950                 955                 960 


Ala Val Thr Leu Ala Glu Ile Trp Lys Thr Thr Tyr Lys Ala Arg Leu 
                965                 970                 975     


Glu 
    


<210>  8
<211>  797
<212>  PRT
<213>  Drosophila

<400>  8

Met Ser Leu Ile Asn Leu Lys Ser Lys Asp Met Tyr Asp Glu Pro Ile 
1               5                   10                  15      


Asn Leu Trp Arg Thr Lys Gln Arg Val His Tyr His His Asp Val Ile 
            20                  25                  30          


Ser Lys Gly Asn Asp Ser His Arg Ser Ser Asp Ala Cys Glu Tyr Ile 
        35                  40                  45              


Thr Ile Ser Ala Pro Lys Lys Ser Gly Ser Phe Ser Arg Ser Pro Pro 
    50                  55                  60                  


Ser Ser Leu Pro Thr Ser Val Pro Gly Thr Pro Arg His Ser Val Ala 
65                  70                  75                  80  


Ala Thr Ser Asn Gln Val Ile Arg Tyr Ala Arg Thr Ser Cys Asp His 
                85                  90                  95      


Cys Gly His His Ser Ile Pro Val Met Ser Pro His Pro Ile Ser Pro 
            100                 105                 110         


Leu Ala Lys Ser Gln Thr Asn Leu Asp Leu Val Glu His Gly Ser Gln 
        115                 120                 125             


Arg Gln Ala Leu Leu Pro Leu Pro Thr Val Gly Met His His Glu Asp 
    130                 135                 140                 


Ser Ala Cys Thr Leu Gln Val Ser Arg Arg Pro Ser Leu Leu Leu Gln 
145                 150                 155                 160 


Glu Ile Leu Thr Gln Arg Pro Pro Leu Phe Gly Arg Arg Asp Gly Asn 
                165                 170                 175     


Gly Phe Leu Ser Pro Arg Thr Ala Lys Asn Gly Asn Leu Gln Gly Thr 
            180                 185                 190         


Ala Ser Gly Ser Thr Ala Thr Ile Asn Phe Gln Ser Gly Ala Thr Ser 
        195                 200                 205             


Ala Arg Asn Gly Ser Thr Ala Phe Phe Asp Asn Gly Ala Lys Ser Phe 
    210                 215                 220                 


Gln Ala Lys Gln Gln Lys Asp Lys Asn Arg Arg Thr Gly Asn Asp Ala 
225                 230                 235                 240 


Ile Ser Ser Ala Leu Ser Ala Thr Tyr Cys Lys Leu Leu Val Leu Leu 
                245                 250                 255     


Gly Val Cys Leu Pro Ile Thr Glu Val Ile Ser Asp Gln Ile Pro Thr 
            260                 265                 270         


Tyr Val Tyr Gln Gly Phe Tyr Val Tyr Leu Tyr Val Gly Ser Ile Leu 
        275                 280                 285             


Phe Val Ile Phe Leu Tyr Ile Ser Ala Phe Arg Asn Arg Ser Leu Phe 
    290                 295                 300                 


Asn Ala Leu Lys Asp Tyr His Glu Lys Asn Ser Asn Val His Leu Lys 
305                 310                 315                 320 


His Lys Val Thr His Phe Gly Ser Phe Tyr Leu Arg Val Gly Ala Ile 
                325                 330                 335     


Ala Phe Ala Ile Gly Thr Met Val Tyr Ser Gly Leu Glu Phe Gly Gln 
            340                 345                 350         


Phe Phe Glu Leu Asn Gly His Pro Gly Cys Arg Asp Val Phe Val Ala 
        355                 360                 365             


Ile Thr Pro Ile Cys Arg Met Val Leu Cys Ile Ala Gln Val Gln Phe 
    370                 375                 380                 


Ile Phe Leu Asn Thr Thr Tyr Met Asp Met Ala Arg His Lys Val Thr 
385                 390                 395                 400 


Ser Arg Phe Gly Leu Met His Met Val Ala Thr Asn Leu Cys Glu Trp 
                405                 410                 415     


Leu Tyr Val Leu Val Glu Glu Thr Lys His Glu Ile Phe His Ile Ser 
            420                 425                 430         


Gln His Glu Val Asp Pro Ala His Asp Leu Val Ile His Asn Ser Ser 
        435                 440                 445             


Met Ser Arg Thr Asp Trp Ala Ala Val Asn Glu Ser Leu His Gln His 
    450                 455                 460                 


His His His His Ala Leu Asn Asn Thr Leu Val Ala Asn Val Ser Ser 
465                 470                 475                 480 


Val Ile Val Asn Met Thr Ile Thr Pro Ser Pro Thr Pro Ala Ala Phe 
                485                 490                 495     


Ser Gly Cys Ser Arg Thr Thr Ile Met Gly Ala Leu Val Gln Gln Leu 
            500                 505                 510         


Ser Pro Phe Leu Phe Pro Cys Thr Ile Glu Tyr Ser Leu Ile Cys Ala 
        515                 520                 525             


Val Ile Leu Phe Glu Met Trp Lys Thr Val Lys Ser Ile Pro Asp Ile 
    530                 535                 540                 


Asp Lys Thr Arg Lys Asn Ser Val Lys Pro Ala Ala Ala Lys Pro Ala 
545                 550                 555                 560 


His His Phe Ser Val Asp Cys Ser Gln Ser His Lys Gly Leu Phe Phe 
                565                 570                 575     


Gly Ile Leu Ile Ile Val Met Thr Ile Ile Ser Met Ile Met Tyr Phe 
            580                 585                 590         


Val Leu Tyr Thr Gln Pro Gly Tyr Glu Leu Val Ala Thr Gln Glu Val 
        595                 600                 605             


Thr Leu Trp Glu Thr Phe Met Tyr Phe Met Cys Ala Ala Ala Val Ile 
    610                 615                 620                 


Thr Gly Met Ile Leu Met Arg Asp Leu Arg Tyr Ile Lys Asn Thr Ser 
625                 630                 635                 640 


Asp Glu His His Ser Met Asp Leu Asp Asn Leu Leu Leu Ile Val Ala 
                645                 650                 655     


Gln Thr Gly Val Tyr Leu Tyr Gly Met Phe Ser Ile Leu Gly Ser Tyr 
            660                 665                 670         


Phe Ala Lys Trp Asp Thr Val Pro Asp Arg Val Glu Gly Ile Ile Ala 
        675                 680                 685             


Glu Val Phe Gly Val Val Gln Thr Ser Leu Gln Thr Met Phe Ile Leu 
    690                 695                 700                 


His Ser Ser His Arg Arg Cys Arg Gly Thr Asn Gln Val Arg Arg Lys 
705                 710                 715                 720 


Pro Gly Arg Glu Ile Ile Thr Phe Leu Leu Val Ala Asn Ile Ala Ile 
                725                 730                 735     


Trp Phe Val Asn Thr Leu Ile Lys Gly Arg Ala Val Phe Arg Glu Ser 
            740                 745                 750         


His Leu Glu Phe Phe Gly Val Trp Gly Trp Thr Ile Ile Thr His Ile 
        755                 760                 765             


Ser Met Pro Leu Ala Ile Phe Tyr Arg Phe His Ser Thr Ile Cys Leu 
    770                 775                 780                 


Phe Glu Val Trp Lys Ile Thr Tyr Lys Ala Lys Ala His 
785                 790                 795         


<210>  9
<211>  1576
<212>  PRT
<213>  Drosophila


<220>
<221>  misc_feature
<222>  (1456)..(1456)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Asp Ser Ser Pro Asp Leu Ser Leu Lys Leu Arg Arg Gly Ser Ser 
1               5                   10                  15      


Asp Ser Arg Asp Asn Phe Tyr Met Asp Phe Ala Gln Gly Ile Asp Ser 
            20                  25                  30          


Asp Ile Glu Glu Val Asp Asn Thr Ala Asn Asn Gln Glu Ala Gly Glu 
        35                  40                  45              


Val Pro Pro Pro Pro Leu Pro Thr Val Ser Leu Ala Glu Glu Val Leu 
    50                  55                  60                  


Leu Leu Val Ala Pro Pro Pro Pro Pro Pro Ser Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Pro Thr Leu Thr Glu Thr Asp Asp Ile Pro Pro Thr Pro Thr Pro 
                85                  90                  95      


Pro Pro Gln Gln Lys Asp Asp Glu Gly Asp Asp Glu Asp Glu Arg Glu 
            100                 105                 110         


Glu Pro Val Pro Glu Gln Asp Gln Gly Ala Pro Ala Ala Pro Ser Pro 
        115                 120                 125             


Pro Gly Ser Pro Ile Asn Ser Val Leu Glu Leu Glu Leu Ile Pro Pro 
    130                 135                 140                 


Pro Pro Leu Ser Pro Met Asp Asp Ala Gly Leu Arg Thr Asp Asp Asp 
145                 150                 155                 160 


Gly Glu Gly Glu Glu Thr Asp Asp Ala Glu Glu Val Ala Ala Ile Pro 
                165                 170                 175     


Pro Pro His Glu Met Leu Asp Ile Glu Ser Asn Pro Asp Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Gln Glu Gln Ala Ser Gln Glu Asp Thr Pro Lys Glu 
        195                 200                 205             


Glu Asp Glu Glu Glu Asp Asp Asp Lys Ser Thr Pro Pro Pro Pro Leu 
    210                 215                 220                 


Pro Pro Leu Pro Ser Asn Phe Ser Tyr Val Gln Gly His Asn Leu Gly 
225                 230                 235                 240 


Gln Val Thr Pro Pro Leu Thr Lys Ser Pro Ser Asn Ser Pro Ser Pro 
                245                 250                 255     


Pro Val Thr Pro Pro Pro Cys Pro Glu Leu Asn Ile Ser Arg Met Val 
            260                 265                 270         


Ser Pro Pro Ala Gln His Ile Ser Gln Ile Pro Pro Leu Thr Pro Ser 
        275                 280                 285             


Asp Glu Ser Glu Gly Glu Ala Glu Ser Gln Pro Asn Ser Pro Pro Leu 
    290                 295                 300                 


Arg Leu Asp Ala Glu Gln Pro Pro Pro Asp Met Asp Gln Pro Glu Pro 
305                 310                 315                 320 


Glu Asp Gln Pro Pro Glu Pro Glu Asn Glu Pro Glu Pro Glu Pro Glu 
                325                 330                 335     


Pro Glu Pro Glu Pro Glu Pro Val Ser Gly Ala Arg Glu Asp Tyr Ser 
            340                 345                 350         


Arg Ser Leu Asp Asn Glu Asp Glu Ser Thr Thr Ile Thr Thr Pro Pro 
        355                 360                 365             


Ser Asn Gly Tyr Ser Ala Ser Ser Ile Ile Ala Pro Pro Pro Glu His 
    370                 375                 380                 


Phe Ala Glu Leu Asp Glu Asp Arg Gly Phe Ile Pro Pro Pro Pro Leu 
385                 390                 395                 400 


Glu Gln Glu Pro Glu Glu Glu Val Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Leu Thr Lys Glu Thr Asp Glu Ile Ser Val Asp Arg Glu Ser 
            420                 425                 430         


Leu Gln Asp Gln Gly Gly Asp Ser Ile Ser Ser Pro Arg Pro Ala Ser 
        435                 440                 445             


Ile Leu Thr Gly Ser Ile Ser Thr Ser Val Gly Gly Gly Ala Gly Gly 
    450                 455                 460                 


Ser Pro Lys Pro Glu Ser Arg Gly Pro Ser Arg Ser Gly Ser Gln Arg 
465                 470                 475                 480 


Ser Gln Leu Arg Ser Gly Ser Gln Gln Gly Ser Ile Ala Glu Ser Arg 
                485                 490                 495     


Gly Gly Ser Arg Ile Gly Ser Arg Thr Gly Ser Val Ala Ser Ala Gln 
            500                 505                 510         


Ala Ala Gly Val Leu Ser Pro Gln Ala Ser Leu Lys Ser Gln Thr Ser 
        515                 520                 525             


Ile Arg Ser Gln Gly Gln Ala Gly Val Arg Ser Pro Ala Gly Ser Ile 
    530                 535                 540                 


Lys Ser Gly Ser Gln Arg Met Gln Ser Pro Gln Ala Gly Glu Gly Ala 
545                 550                 555                 560 


Pro Ala Met Pro Ser Pro Pro Leu Met Arg Ser Pro Pro Pro Glu Leu 
                565                 570                 575     


Ala Arg Gln Met His Ser Pro Pro Arg Ile Thr Thr Pro Pro Arg Val 
            580                 585                 590         


Cys Ser Pro Pro Leu Val Ser Ser Pro Pro Lys Leu Ala Glu Ser Ala 
        595                 600                 605             


Ala Ala Ala Val Gly Val Ala Ala Thr Val Lys Glu Gln Ile Gly Ser 
    610                 615                 620                 


Ser Ser Ser Thr Ala Glu Pro Leu Glu Pro Ser Lys Pro Glu Pro Leu 
625                 630                 635                 640 


Lys Pro Pro Ile Ala Thr Val Ser Tyr Gln Asp Glu Gln Lys Pro Ser 
                645                 650                 655     


Pro Pro Pro Thr Ala Ala Ala Ala Pro Ala Val Thr Thr Thr Ala Ala 
            660                 665                 670         


Thr Thr Ala Val Thr Ser Gln Pro Arg Ser His Phe Thr Ser Ser His 
        675                 680                 685             


His His Tyr His Leu Pro His Gln Phe Gln His Pro His His Gln Asn 
    690                 695                 700                 


His His Thr His Ser Val Arg Val Pro Thr Pro Thr Val Pro Ser Ser 
705                 710                 715                 720 


Tyr Ala Pro Pro Pro Pro Pro Asp Ser Gly Ser Ser Ser Ser Pro Val 
                725                 730                 735     


Asp Arg Arg Arg Leu Phe Met Ala Gly Val Ala Pro Pro Ile Ala Ala 
            740                 745                 750         


Gly Ala Gly Ser Leu Met Ala Met Pro Ala Glu Pro Ala Val Ala Ile 
        755                 760                 765             


Ser Pro Gly Arg Val Ser Ala Arg Ser Gly Ser Gln His His Val Thr 
    770                 775                 780                 


Ile Asp Glu Ser Ser Leu Pro Ser His Lys Gly Asn Ile Gln Glu Thr 
785                 790                 795                 800 


Pro Gly Pro Ser Gly Leu Ile Ile Gly Gly Gly Asp Gly Asp Gly Asp 
                805                 810                 815     


Arg Asp Ile Gly Gly Gly Gly Gly Pro Asp Ser Ser Asp Pro Pro Ser 
            820                 825                 830         


Ser Pro Gly Gly Ser Ser Ser Gln Pro Ala Leu Ser Gly Ser Gln Ala 
        835                 840                 845             


Asp Gly Gln Leu Ala Leu Met Tyr His Ser His Gln Leu Thr Asn Tyr 
    850                 855                 860                 


Pro Val Leu Pro Ala Ile Lys Arg Thr His Arg Pro Ser Phe Val Tyr 
865                 870                 875                 880 


Pro Pro Met Pro Arg Val Lys Ala Gly Asp Ala Leu Ala Thr Leu Phe 
                885                 890                 895     


Ser Ala Leu Tyr Gly Lys Leu Leu Val Val Met Gly Ile Ala Phe Pro 
            900                 905                 910         


Met Ala Glu Val Ile Ser Thr Tyr Ile Pro Pro Ser Phe Tyr Glu Val 
        915                 920                 925             


Tyr Tyr Leu Tyr Leu Tyr Ile Gly Ser Met Ile Phe Leu Leu Phe Met 
    930                 935                 940                 


Tyr Ala Thr Leu Ile Trp Gly Arg Pro Lys Leu Pro Val Pro Ile Ala 
945                 950                 955                 960 


Ser Pro Ser Lys Ser Ala Thr Lys Ala Ser Gly Thr Asp Ser Met Asp 
                965                 970                 975     


Glu Ser Asp Thr Asp Ser Asn Ser Val His His Arg Leu Pro Pro Pro 
            980                 985                 990         


Ile Pro Val Arg Arg Pro Ser Leu  Leu Ser Pro Leu Gly  Arg Arg Asp 
        995                 1000                 1005             


Ala His  Tyr Gly Ser Phe Tyr  Leu Arg Met Gly Ala  Val Ala Phe 
    1010                 1015                 1020             


Gly Ile  Gly Ser Met Ile Tyr  Ser Gly Leu Glu Phe  Gly Gln Tyr 
    1025                 1030                 1035             


Phe Glu  Leu Asn Pro Asp Thr  Lys Cys His Asn Val  Leu Leu Ala 
    1040                 1045                 1050             


Leu Thr  Pro Ala Thr Arg Met  Ala Phe Ile Phe Ile  Gln Met Tyr 
    1055                 1060                 1065             


Phe Ile  Phe Leu Asn Asn Glu  Gln Ile Lys Val Tyr  Arg Tyr Lys 
    1070                 1075                 1080             


Ile Ile  Ala Arg Phe Gly Leu  Met His Met Ile Gly  Thr Asn Leu 
    1085                 1090                 1095             


Ala Val  Trp Leu Asn Val Leu  Ile Gln Glu Thr Lys  His Glu Ile 
    1100                 1105                 1110             


Leu Thr  Phe Tyr Asn Pro Glu  Asn Arg Thr Leu Arg  Ile Ser His 
    1115                 1120                 1125             


Arg Ile  Pro Gly His Ser Arg  Gly His Ala Ile Ile  Gln His Asp 
    1130                 1135                 1140             


Pro Thr  Ala His Leu Arg Val  Pro Arg Gly Leu Lys  Gly Pro Tyr 
    1145                 1150                 1155             


Gln Ile  Phe Glu Cys Arg Arg  Thr Asn Ile Ile Gly  Thr Leu Val 
    1160                 1165                 1170             


Gln Asp  Ala Ser Pro Phe Leu  Phe Pro Cys Thr Ile  Glu Tyr Ser 
    1175                 1180                 1185             


Leu Ile  Cys Ala Ala Ile Leu  Tyr Val Met Trp Arg  Ser Ile Ser 
    1190                 1195                 1200             


Arg Pro  Gln Thr Pro Thr Pro  Gln Arg Pro Asp Met  Ile Ser Ser 
    1205                 1210                 1215             


Pro Met  Lys Arg Ser Pro His  His Tyr Ser Val Asp  Cys Ala Arg 
    1220                 1225                 1230             


Ala His  Lys Gly Leu Phe Val  Gly Ile Leu Ile Leu  Val Leu Thr 
    1235                 1240                 1245             


Ile Ile  Ser Leu Ile Ile Phe  Phe Val Leu Ile Ser  Arg Pro Glu 
    1250                 1255                 1260             


Phe Val  Ala Met Ala Val Thr  Glu Val Thr Ile Cys  Glu Leu Leu 
    1265                 1270                 1275             


Ile Tyr  Gly Thr Ala Thr Ile  Ala Thr Leu Val Gly  Met Ile Gln 
    1280                 1285                 1290             


Ile Arg  His Leu Gln Tyr Asp  Ala Tyr Arg Ser Phe  Ser Leu Asp 
    1295                 1300                 1305             


Asp Ile  Leu Leu Val Gly Ala  Gln Thr Gly Ser Phe  Leu Tyr Asn 
    1310                 1315                 1320             


Ile Phe  Thr Val Ile Ala Gly  His Phe Thr Leu Arg  Ser Asp Asp 
    1325                 1330                 1335             


Met Leu  Val Pro Ile Asn Ala  Leu Ala Ser Ile Val  Gln Thr Ala 
    1340                 1345                 1350             


Cys Gln  Thr Met Phe Ile Leu  Asp Ala Ser Arg Arg  Gln Ala Val 
    1355                 1360                 1365             


Ser Pro  Glu His Leu Arg Lys  Lys Pro Gly Arg Glu  Ile Val Thr 
    1370                 1375                 1380             


Phe Met  Leu Val Val Asn Leu  Ala Met Trp Ala Ile  Ser Thr Leu 
    1385                 1390                 1395             


Glu Lys  Ser Arg Ala Glu Ser  His Pro Ile Gln Leu  Asn Phe Tyr 
    1400                 1405                 1410             


Gly Leu  Trp Ala Trp Thr Ile  Ile Thr His Val Ser  Met Pro Leu 
    1415                 1420                 1425             


Ala Ile  Phe Tyr Arg Phe His  Ser Thr Val Cys Leu  Cys Glu Ile 
    1430                 1435                 1440             


Trp Lys  Arg Ala Tyr Lys Leu  Lys Pro Thr Tyr Met  Xaa Glu Phe 
    1445                 1450                 1455             


Ala Arg  Ser Arg Ile Gln Ser  Ile Ala Gln Gln Gln  Gln Phe Cys 
    1460                 1465                 1470             


Glu Asp  Leu Lys Thr Asn Leu  Ser Tyr Cys Tyr Cys  Ser Thr Thr 
    1475                 1480                 1485             


Leu Ala  Gly Gly Glu Leu Glu  Thr Val Glu Glu Val  Asp Ser Gly 
    1490                 1495                 1500             


Glu Ser  Asn Ser Ala Glu Asp  Ala Gly Ala Gly Ala  Gly Ser Gly 
    1505                 1510                 1515             


Gly Ser  Arg Gly Ser Gly Gly  Gly Ala Gly Ala Ala  Glu Ala Gly 
    1520                 1525                 1530             


Glu Ala  Gly Glu Glu Gly Gln  Gln Gly Gly Asp Ser  Ser Cys Gly 
    1535                 1540                 1545             


Leu Lys  Ala Pro Ile Arg Ala  Leu Ser Pro Gln Ser  Leu Asn Thr 
    1550                 1555                 1560             


Glu Lys  Ala Phe Cys Pro Val  Tyr Val Ile Asn Gly  Glu 
    1565                 1570                 1575     


