                         SEQUENCE LISTING

<110>  NomoCan Pharmaceuticals LLC
 
<120>  ANTIBODIES TO M(H)DM2/4 AND THEIR USE IN DIAGNOSING AND TREATING 
       CANCER

<130>  14160-006-228

<150>  US 62/537,914
<151>  2017-07-27

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NMC-P1

<400>  1

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr 
1               5                   10                  15  


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NMC-P2

<400>  2

Thr Thr Ser Gln Ile Pro Ala Ser Glu Gln Glu 
1               5                   10      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NMC-P3

<400>  3

Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe 
1               5                   10                  15      


Pro 
    


<210>  4
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  5
<211>  489
<212>  PRT
<213>  Mouse

<400>  5

Met Cys Asn Thr Asn Met Ser Val Ser Thr Glu Gly Ala Ala Ser Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Asn Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Ile Ile Phe Tyr Ile Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Val Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Ala Met Ile Tyr Arg Asn Leu Val Ala Val Ser Gln 
            100                 105                 110         


Gln Asp Ser Gly Thr Ser Leu Ser Glu Ser Arg Arg Gln Pro Glu Gly 
        115                 120                 125             


Gly Ser Asp Leu Lys Asp Pro Leu Gln Ala Pro Pro Glu Glu Lys Pro 
    130                 135                 140                 


Ser Ser Ser Asp Leu Ile Ser Arg Leu Ser Thr Ser Ser Arg Arg Arg 
145                 150                 155                 160 


Ser Ile Ser Glu Thr Glu Glu Asn Thr Asp Glu Leu Pro Gly Glu Arg 
                165                 170                 175     


His Arg Lys Arg Arg Arg Ser Leu Ser Phe Asp Pro Ser Leu Gly Leu 
            180                 185                 190         


Cys Glu Leu Arg Glu Met Cys Ser Gly Gly Ser Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Ser Ser Glu Ser Thr Glu Thr Pro Ser His Gln Asp Leu Asp Asp 
    210                 215                 220                 


Gly Val Ser Glu His Ser Gly Asp Cys Leu Asp Gln Asp Ser Val Ser 
225                 230                 235                 240 


Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp 
                245                 250                 255     


Tyr Ser Leu Ser Asp Glu Gly His Glu Leu Ser Asp Glu Asp Asp Glu 
            260                 265                 270         


Val Tyr Arg Val Thr Val Tyr Gln Thr Gly Glu Ser Asp Thr Asp Ser 
        275                 280                 285             


Phe Glu Gly Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr 
    290                 295                 300                 


Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Lys Arg Cys 
305                 310                 315                 320 


Trp Thr Leu Arg Glu Asn Trp Leu Pro Asp Asp Lys Gly Lys Asp Lys 
                325                 330                 335     


Val Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Ala Gln Ala Glu 
            340                 345                 350         


Glu Gly Leu Asp Val Pro Asp Gly Lys Lys Leu Thr Glu Asn Asp Ala 
        355                 360                 365             


Lys Glu Pro Cys Ala Glu Glu Asp Ser Glu Glu Lys Ala Glu Gln Thr 
    370                 375                 380                 


Pro Leu Ser Gln Glu Ser Asp Asp Tyr Ser Gln Pro Ser Thr Ser Ser 
385                 390                 395                 400 


Ser Ile Val Tyr Ser Ser Gln Glu Ser Val Lys Glu Leu Lys Glu Glu 
                405                 410                 415     


Thr Gln Asp Lys Asp Glu Ser Val Glu Ser Ser Phe Ser Leu Asn Ala 
            420                 425                 430         


Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile 
        435                 440                 445             


Val His Gly Lys Thr Gly His Leu Met Ser Cys Phe Thr Cys Ala Lys 
    450                 455                 460                 


Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile 
465                 470                 475                 480 


Gln Met Ile Val Leu Thr Tyr Phe Asn 
                485                 


<210>  6
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Ser Met 
        115                 120                 125             


Asp Ile Pro Ser Gln Asp Gln Leu Lys Gln Ser Ala Glu Glu Ser Ser 
    130                 135                 140                 


Thr Ser Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Glu His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


Asn Leu Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser 
        195                 200                 205             


Asn Tyr Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Val Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp 
            260                 265                 270         


Lys Lys Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys 
        275                 280                 285             


Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp 
    290                 295                 300                 


Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys 
305                 310                 315                 320 


Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys 
                325                 330                 335     


Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys 
            340                 345                 350         


Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys 
    370                 375                 380                 


Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser 
385                 390                 395                 400 


Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn 
                405                 410                 415     


Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn 
            420                 425                 430         


Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn 
        435                 440                 445             


Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala 
    450                 455                 460                 


Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 490 


<210>  7
<211>  127
<212>  PRT
<213>  Mouse

<400>  7

Met Thr Ser His Ser Thr Ser Ala Gln Cys Ser Ala Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Ser Glu Gln Ile Ser Gln Val Arg Pro Lys Leu Gln 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Val Phe Thr 
        35                  40                  45              


Met Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Asp Leu Leu Gly Cys Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Ser Ala Ser Ile 
            100                 105                 110         


Asn Thr Ala Arg Cys Asn Arg Ile Leu Gln Ser Gln Lys Lys Asn 
        115                 120                 125         


<210>  8
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-A

<400>  8

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Leu Asp Ala Gly 
            20                  25                  30          


Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp 
        35                  40                  45              


Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr 
    50                  55                  60                  


Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Val 
65                  70                  75                  80  


Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe 
                85                  90                  95      


Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser 
            100                 105                 110         


Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp 
        115                 120                 125             


Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly 
    130                 135                 140                 


Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu 
145                 150                 155                 160 


Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg 
                165                 170                 175     


Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln 
            180                 185                 190         


Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile 
        195                 200                 205             


Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr 
    210                 215                 220                 


Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile 
225                 230                 235                 240 


Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val 
                245                 250                 255     


His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys 
            260                 265                 270         


Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln 
        275                 280                 285             


Met Ile Val Leu Thr Tyr Phe Pro 
    290                 295     


<210>  9
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-A1

<400>  9

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Leu Asp Ala Gly 
            20                  25                  30          


Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp 
        35                  40                  45              


Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr 
    50                  55                  60                  


Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Asp 
65                  70                  75                  80  


Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser 
                85                  90                  95      


His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp 
            100                 105                 110         


Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn 
        115                 120                 125             


Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr 
    130                 135                 140                 


Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys 
145                 150                 155                 160 


Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro 
                165                 170                 175     


Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu 
            180                 185                 190         


Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser 
        195                 200                 205             


Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro 
    210                 215                 220                 


Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys 
225                 230                 235                 240 


Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val 
                245                 250                 255     


Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
            260                 265                 270 


<210>  10
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-B

<400>  10

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Tyr Trp Lys Cys 
            20                  25                  30          


Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn Arg 
        35                  40                  45              


Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp 
    50                  55                  60                  


Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala 
65                  70                  75                  80  


Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn Asp 
                85                  90                  95      


Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala 
            100                 105                 110         


Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser 
        115                 120                 125             


Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg Glu 
    130                 135                 140                 


Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu Asn 
145                 150                 155                 160 


Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys 
                165                 170                 175     


Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys Ala 
            180                 185                 190         


Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro 
        195                 200                 205             


Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
    210                 215             


<210>  11
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-C

<400>  11

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp 
    50                  55                  60                  


Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu 
65                  70                  75                  80  


Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln 
                85                  90                  95      


Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln 
            100                 105                 110         


Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser 
        115                 120                 125             


Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro 
    130                 135                 140                 


Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu 
145                 150                 155                 160 


Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys 
                165                 170                 175     


Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys 
            180                 185                 190         


Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn 
        195                 200                 205             


Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr 
    210                 215                 220                 


Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp 
225                 230                 235                 240 


Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val 
                245                 250                 255     


Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln 
            260                 265                 270         


Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu 
        275                 280                 285             


Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro 
    290                 295                 300                 


Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe 
305                 310                 315                 320 


Pro 
    


<210>  12
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-D

<400>  12

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Gln Glu Ser 
            20                  25                  30          


Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser 
        35                  40                  45              


Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu 
    50                  55                  60                  


Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val 
65                  70                  75                  80  


Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr 
                85                  90                  95      


Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg 
            100                 105                 110         


Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu 
        115                 120                 125             


Thr Tyr Phe Pro 
    130         


<210>  13
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-E

<400>  13

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Asn Asp Cys Ala Asn 
65                  70                  75                  80  


Leu Phe Pro Leu Val Asp Leu Ser Ile Arg Glu Leu Tyr Ile Ser Asn 
                85                  90                  95      


Tyr Ile Thr Leu Gly Ile 
            100         


<210>  14
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-F

<400>  14

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val 
    50                  55                  60                  


Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn 
65                  70                  75                  80  


Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu 
                85                  90                  95      


Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser 
            100                 105                 110         


Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp 
        115                 120                 125             


Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile 
    130                 135                 140                 


Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile 
145                 150                 155                 160 


Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn 
                165                 170                 175     


Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp 
            180                 185                 190         


Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser 
        195                 200                 205             


Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser 
    210                 215                 220                 


Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu 
225                 230                 235                 240 


Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp 
                245                 250                 255     


Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser 
            260                 265                 270         


His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp 
        275                 280                 285             


Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn 
    290                 295                 300                 


Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr 
305                 310                 315                 320 


Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys 
                325                 330                 335     


Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro 
            340                 345                 350         


Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu 
        355                 360                 365             


Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser 
    370                 375                 380                 


Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro 
385                 390                 395                 400 


Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys 
                405                 410                 415     


Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val 
            420                 425                 430         


Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
        435                 440                 445     


<210>  15
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-G

<400>  15

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Glu Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg 
        115                 120                 125             


His Lys Ser Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu 
    130                 135                 140                 


Cys Val Ile Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser 
145                 150                 155                 160 


Thr Gly Thr Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu His 
                165                 170                 175     


Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val 
            180                 185                 190         


Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu 
        195                 200                 205             


Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr 
    210                 215                 220                 


Val Tyr Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro 
225                 230                 235                 240 


Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met 
                245                 250                 255     


Asn Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu 
            260                 265                 270         


Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu 
        275                 280                 285             


Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val 
    290                 295                 300                 


Pro Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val 
305                 310                 315                 320 


Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser 
                325                 330                 335     


Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser 
            340                 345                 350         


Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu 
        355                 360                 365             


Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val 
    370                 375                 380                 


Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr 
385                 390                 395                 400 


Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg 
                405                 410                 415     


Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu 
            420                 425                 430         


Thr Tyr Phe Pro 
        435     


<210>  16
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-11

<400>  16

Met Val Arg Ser Arg Gln Met Cys Asn Thr Asn Met Ser Val Pro Thr 
1               5                   10                  15      


Asp Gly Ala Val Thr Thr Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr 
            20                  25                  30          


Leu Val Arg Pro Lys Pro Leu Leu Leu Lys Leu Leu Lys Ser Val Gly 
        35                  40                  45              


Ala Gln Lys Asp Thr Tyr Thr Met Lys Glu Val Leu Phe Tyr Leu Gly 
    50                  55                  60                  


Gln Tyr Ile Met Thr Lys Arg Leu Tyr Asp Glu Lys Gln Gln His Ile 
65                  70                  75                  80  


Val Tyr Cys Ser Asn Asp Leu Leu Gly Asp Leu Phe Gly Val Pro Ser 
                85                  90                  95      


Phe Ser Val Lys Glu His Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn 
            100                 105                 110         


Leu Val Val Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser Val 
        115                 120                 125             


Ser Glu Asn Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu 
    130                 135                 140                 


Val Gln Glu Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val Ser 
145                 150                 155                 160 


Arg Pro Ser Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu 
                165                 170                 175     


Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys Ser 
            180                 185                 190         


Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val Ile 
        195                 200                 205             


Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr 
    210                 215                 220                 


Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp 
225                 230                 235                 240 


Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu 
                245                 250                 255     


Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln 
            260                 265                 270         


Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln 
        275                 280                 285             


Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser 
    290                 295                 300                 


Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro 
305                 310                 315                 320 


Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu 
                325                 330                 335     


Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys 
            340                 345                 350         


Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys 
        355                 360                 365             


Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn 
    370                 375                 380                 


Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr 
385                 390                 395                 400 


Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp 
                405                 410                 415     


Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val 
            420                 425                 430         


Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln 
        435                 440                 445             


Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu 
    450                 455                 460                 


Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro 
465                 470                 475                 480 


Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe 
                485                 490                 495     


Pro 
    


<210>  17
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDM2 variant MDM2-KB2

<400>  17

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn 
    50                  55                  60                  


Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn 
65                  70                  75                  80  


Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys 
                85                  90                  95      


Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro 
            100                 105                 110         


Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu 
        115                 120                 125             


Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu 
    130                 135                 140                 


Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln 
145                 150                 155                 160 


Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu 
                165                 170                 175     


Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile 
            180                 185                 190         


Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly 
        195                 200                 205             


His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn 
    210                 215                 220                 


Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr 
225                 230                 235                 240 


Tyr Phe Pro 
            


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H2 region (Chothia)

<400>  18

Gly Phe Thr Phe Thr His Tyr 
1               5           


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H1 region (Kabat)

<400>  19

Arg Asn Lys Ala Lys Gly Tyr Thr 
1               5               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H3 region (Chothia)

<400>  20

Asp Ile Gly Asp Asn 
1               5   


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L1 region (Chothia)

<400>  21

Arg Ser Ser Lys Asn Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L2 region (Chothia)

<400>  22

Arg Val Ser Asn Leu Ala Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L3 region (Chothia)

<400>  23

Ala Gln Leu Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H1 region (Chothia)

<400>  24

Gly Asp Thr Leu Ser Gly Ser 
1               5           


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H2 region (Chothia)

<400>  25

His Leu Asn Arg Gly Thr 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H3 region (Chothia)

<400>  26

Ser Pro Gly Phe Ala Tyr 
1               5       


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L1 region (Chothia)

<400>  27

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Ser Tyr Leu Tyr 
1               5                   10                  15      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L2 region (Chothia)

<400>  28

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L3 region (Chothia)

<400>  29

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H1 region (Chothia)

<400>  30

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H2 region (Chothia)

<400>  31

Asn Pro Arg Asn Gly Gly 
1               5       


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H3 region (Chothia)

<400>  32

Ser Gly Tyr Tyr Ala Met Asp Tyr 
1               5               


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L1 region (Chothia)

<400>  33

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L2 region (Chothia)

<400>  34

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L3 region (Chothia)

<400>  35

Gln Gln Gly Asn Thr Leu Pro Arg Thr 
1               5                   


<210>  36
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain Variable Region 

<400>  36

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Thr His Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Lys Gly Tyr Thr Ala Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ile Gly Asp Asn Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain Variable Region 

<400>  37

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Asn Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Ser Arg Val Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ala Gln Leu 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain Variable Region 

<400>  38

Glu Val Gln Leu Gln Glu Ser Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Asp Thr Leu Ser Gly Ser 
            20                  25                  30          


Trp Met His Trp Ala Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Leu Asn Arg Gly Thr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Val Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain Variable Region 

<400>  39

Gly Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Ser Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain Variable Region 

<400>  40

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Arg Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain Variable Region 

<400>  41

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H1 region (AbM)

<400>  42

Gly Phe Thr Phe Thr His Tyr Tyr Met Ser 
1               5                   10  


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H1 region (Kabat)

<400>  43

His Tyr Tyr Met Ser 
1               5   


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H1 region (Contact)

<400>  44

Thr His Tyr Tyr Met Ser 
1               5       


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H2 region (AbM)

<400>  45

Phe Ile Arg Asn Lys Ala Lys Gly Tyr Thr Ala Glu 
1               5                   10          


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H2 region (Kabat)

<400>  46

Phe Ile Arg Asn Lys Ala Lys Gly Tyr Thr Ala Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H2 region (Contact)

<400>  47

Trp Leu Gly Phe Ile Arg Asn Lys Ala Lys Gly Tyr Thr Ala Glu 
1               5                   10                  15  


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H3 region (Contact)

<400>  48

Ala Arg Asp Ile Gly Asp 
1               5       


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L1 region (Contact)

<400>  49

Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
1               5                   10          


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L2 region (Contact)

<400>  50

Leu Leu Ile Ser Arg Val Ser Asn Leu Ala 
1               5                   10  


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L3 region (Contact)

<400>  51

Ala Gln Leu Leu Glu Leu Pro Tyr 
1               5               


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H1 region (AbM)

<400>  52

Gly Asp Thr Leu Ser Gly Ser Trp Met His 
1               5                   10  


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H1 region (Kabat)

<400>  53

Gly Ser Trp Met His 
1               5   


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H1 region (Contact)

<400>  54

Ser Gly Ser Trp Met His 
1               5       


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H2 region (AbM)

<400>  55

Glu Ile His Leu Asn Arg Gly Thr Thr Asn 
1               5                   10  


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H2 region (Kabat)

<400>  56

Glu Ile His Leu Asn Arg Gly Thr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H2 region (Contact)

<400>  57

Trp Ile Gly Glu Ile His Leu Asn Arg Gly Thr Thr Asn 
1               5                   10              


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H3 region (Contact)

<400>  58

Ala Arg Ser Pro Gly Phe Ala 
1               5           


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L1 region (Contact)

<400>  59

Leu His Ser Asn Gly Asn Ser Tyr Leu Tyr Trp Phe 
1               5                   10          


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L2 region (Contact)

<400>  60

Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
1               5                   10  


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L3 region (Contact)

<400>  61

Met Gln His Leu Glu Tyr Pro Phe 
1               5               


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H1 region (AbM)

<400>  62

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met Tyr 
1               5                   10  


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H1 region (Kabat)

<400>  63

Ser Tyr Tyr Met Tyr 
1               5   


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H1 region (Contact)

<400>  64

Thr Ser Tyr Tyr Met Tyr 
1               5       


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H2 region (AbM)

<400>  65

Gly Ile Asn Pro Arg Asn Gly Gly Thr Asn 
1               5                   10  


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H2 region (Kabat)

<400>  66

Gly Ile Asn Pro Arg Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H2 region (Contact)

<400>  67

Trp Ile Gly Gly Ile Asn Pro Arg Asn Gly Gly Thr Asn 
1               5                   10              


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in CDR-H3 region (Contact)

<400>  68

Thr Arg Ser Gly Tyr Tyr Ala Met Asp 
1               5                   


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L1 region (Contact)

<400>  69

Ser Asn Phe Leu Asn Trp Tyr 
1               5           


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L2 region (Contact)

<400>  70

Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
1               5                   10  


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in CDR-L3 region (Contact)

<400>  71

Gln Gln Gly Asn Thr Leu Pro Arg 
1               5               


<210>  72
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR1 region (Chothia)

<400>  72

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser 
            20                  25  


<210>  73
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR1 region (Kabat)

<400>  73

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Thr 
            20                  25                  30  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR1 region (Contact)

<400>  74

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe 
            20                  25                  


<210>  75
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR2 region (Chothia)

<400>  75

Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
1               5                   10                  15      


Gly Phe Ile 
            


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR2 region (Kabat)

<400>  76

Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR2 region (Contact)

<400>  77

Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu 
1               5                   10      


<210>  78
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR3 region (Chothia)

<400>  78

Ala Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu 
            20                  25                  30          


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  79
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR3 region (AbM)

<400>  79

Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Ser 
            20                  25                  30          


Ala Thr Tyr Tyr Cys Ala Arg 
        35                  


<210>  80
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR3 region (Kabat)

<400>  80

Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  81
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR3 region (Contact)

<400>  81

Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Ser 
            20                  25                  30          


Ala Thr Tyr Tyr Cys 
        35          


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR4 region (Chothia)

<400>  82

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in HFR4 region (Contact)

<400>  83

Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  84
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR1 region (Chothia)

<400>  84

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys 
            20              


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR1 region (Contact)

<400>  85

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Asn Leu 
            20                  25                  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR2 region (Chothia)

<400>  86

Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Ser 
1               5                   10                  15  


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR2 region (Contact)

<400>  87

Leu Gln Arg Pro Gly Gln Ser Pro Gln 
1               5                   


<210>  88
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR3 region (Chothia)

<400>  88

Gly Val Pro Asn Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR3 region (Contact)

<400>  89

Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            20                  25                  30          


Cys 
    


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR4 region (Chothia)

<400>  90

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in LFR4 region (Contact)

<400>  91

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  92
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR1 region (Chothia)

<400>  92

Glu Val Gln Leu Gln Glu Ser Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR1 region (Kabat)

<400>  93

Glu Val Gln Leu Gln Glu Ser Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Asp Thr Leu Ser 
            20                  25                  30  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR1 region (Contact)

<400>  94

Glu Val Gln Leu Gln Glu Ser Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Asp Thr Leu 
            20                  25                  


<210>  95
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR2 region (Chothia)

<400>  95

Trp Met His Trp Ala Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Glu Ile 
            


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR2 region (Kabat)

<400>  96

Trp Ala Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR2 region (Contact)

<400>  97

Trp Ala Met Gln Arg Pro Gly Gln Gly Leu Glu 
1               5                   10      


<210>  98
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR3 region (Chothia)

<400>  98

Thr Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Val Thr Val Asp 
1               5                   10                  15      


Thr Ser Ser Ser Thr Ala Tyr Val Asp Leu Ser Ser Leu Thr Ser Glu 
            20                  25                  30          


Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  99
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR3 region (Kabat)

<400>  99

Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Val Thr Val Asp Thr Ser 
1               5                   10                  15      


Ser Ser Thr Ala Tyr Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  100
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR3 region (Kabat)

<400>  100

Lys Ala Thr Val Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Val Asp 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  101
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR3 region (Contact)

<400>  101

Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Val Thr Val Asp Thr Ser 
1               5                   10                  15      


Ser Ser Thr Ala Tyr Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR4 region (Chothia)

<400>  102

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  103
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in HFR4 region (Contact)

<400>  103

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10          


<210>  104
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR1 region (Chothia)

<400>  104

Gly Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys 
            20              


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR1 region (Contact)

<400>  105

Gly Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
            20                  25                  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR2 region (Chothia)

<400>  106

Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR2 region (Contact)

<400>  107

Leu Gln Arg Pro Gly Gln Ser Pro Gln 
1               5                   


<210>  108
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR3 region (Chothia)

<400>  108

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
1               5                   10                  15      


Leu Arg Ile Thr Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  109
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR3 region (Contact)

<400>  109

Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
1               5                   10                  15      


Thr Leu Arg Ile Thr Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR4 region (Chothia)

<400>  110

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in LFR4 region (Contact)

<400>  111

Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  112
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR1 region (Chothia)

<400>  112

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  113
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR1 region (Kabat)

<400>  113

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR1 region (Contact)

<400>  114

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            20                  25                  


<210>  115
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR2 region (Chothia)

<400>  115

Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Gly Ile 
            


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR2 region (Kabat)

<400>  116

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR2 region (Contact)

<400>  117

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
1               5                   10      


<210>  118
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR3 region (Chothia)

<400>  118

Thr Asn Phe Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala Asp 
1               5                   10                  15      


Lys Ser Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            20                  25                  30          


Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
        35                  40      


<210>  119
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR3 region (AbM)

<400>  119

Phe Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser 
1               5                   10                  15      


Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys Thr Arg 
        35                  


<210>  120
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR3 region (Kabat)

<400>  120

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  121
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR3 region (Contact)

<400>  121

Phe Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser 
1               5                   10                  15      


Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR4 region (Chothia)

<400>  122

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  123
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain in HFR4 region (Contact)

<400>  123

Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10          


<210>  124
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR1 region (Chothia)

<400>  124

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR1 region (Contact)

<400>  125

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
            20                  25                  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR2 region (Chothia)

<400>  126

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR2 region (Contact)

<400>  127

Gln Gln Lys Pro Asp Gly Thr Val Lys 
1               5                   


<210>  128
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR3 region (Chothia)

<400>  128

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  129
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR3 region (Contact)

<400>  129

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
1               5                   10                  15      


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Cys 
    


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR4 region (Chothia)

<400>  130

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain in LFR4 region (Contact)

<400>  131

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  132
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain Variable Region

<400>  132
gaggtgcagc tgcaggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtacaa cttctgggtt caccttcact cattactaca tgagctgggt ccgccagcct      120

ccaggcaagg cacttgagtg gttgggcttt attagaaata aagctaaggg ttacacagca      180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaacac cctgagacct gaggacagtg ccacttatta ctgtgcaaga      300

gatattgggg acaactgggg tcaaggaacc ttagtcaccg tctcctcag                  349


<210>  133
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 heavy chain

<400>  133
atgggatgga actatatcat cctctttttg gtagcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagttgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactatatgt actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggggggatt aatcctagga atggtggtac taacttcaat      240

gagaagttca agaacaaggc cacactgact gcagacaaat cctccaccac agcctacatg      300

caactcagta gcctgacatc tgaggactct gcggtctatt actgtacaag atctggttac      360

tatgctatgg actattgggg tcaaggaacc tcagtcaccg tctcctca                   408


<210>  134
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain Variable Region 

<400>  134
gatattgtga tgacgcaggc tgccttctcc aatccagtca ctcttggaac atcagcttcc       60

atctcctgca ggtctagtaa gaatctccta catagtaatg gcatcactta tttgtattgg      120

tatctgcaga ggccaggcca gtctcctcag ctcctgatat ctcgggtgtc caatctggcc      180

tcaggagtcc caaacaggtt cagtggcagt gagtcaggaa ctgatttcac actgagaatc      240

agcagagtgg aggctgagga tgtgggtgtt tatttctgtg ctcaactgct agaactcccg      300

tacacgttcg gaggggggac caagttggaa ataaaac                               337


<210>  135
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 heavy chain variable region

<400>  135

Met Gly Trp Asn Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile Asn Pro Arg Asn Gly Gly Thr Asn Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  136
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain Variable Region 

<400>  136
gaggtgcagc tgcaggagtc tgggtctgtg ctggtgaggc ctggagcttc agtgaagctg       60

tcctgcaagg cttctggcga caccctcagc ggctcctgga tgcactgggc gatgcagagg      120

cctggacaag gccttgagtg gattggagag attcatctta atagaggtac tactaactac      180

aatgagaagt tcaagggcaa ggccacagtg actgtggaca catcctccag cacagcctac      240

gtggatctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaagcccg      300

gggtttgctt actggggcca agggactctg gtcactgtct ctgcag                     346


<210>  137
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 light chain variable region

<400>  137
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagc aattttttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttcctcggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  138
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain Variable Region

<400>  138
ggcattgtga tgacccaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacagtta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

actagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcct      300

ttcacgttcg gctcggggac aaagttggaa ataaaac                               337


<210>  139
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 light chain variable region

<400>  139

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Phe Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  140
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Heavy Chain Variable Region

<400>  140
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc agctactata tgtactgggt gaagcagagg      120

cctggacaag gccttgagtg gattgggggg attaatccta ggaatggtgg tactaacttc      180

aatgagaagt tcaagaacaa ggccacactg actgcagaca aatcctccac cacagcctac      240

atgcaactca gtagcctgac atctgaggac tctgcggtct attactgtac aagatctggt      300

tactatgcta tggactattg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H2 region (IMGT)

<400>  141

Ile His Leu Asn Arg Gly Thr Thr 
1               5               


<210>  142
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb NMC-303 Light Chain Variable Region 

<400>  142
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattttttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Light Chain in CDR-L1 region (IMGT)

<400>  143

Lys Ser Leu Leu His Ser Asn Gly Asn Ser Tyr 
1               5                   10      


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H1 region (IMGT)

<400>  144

Phe Thr Phe Thr His Tyr Tyr 
1               5           


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H2 region (IMGT)

<400>  145

Ile Arg Asn Lys Ala Lys Gly Tyr Thr Ala 
1               5                   10  


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Heavy Chain in CDR-H3 region (IMGT)

<400>  146

Ala Arg Asp Ile Gly Asp Asn 
1               5           


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-103 Light Chain in CDR-L1 region (IMGT)

<400>  147

Lys Asn Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      
      

<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb NMC-204 Heavy Chain in CDR-H1 region (IMGT)

<400>  148

Gly Asp Thr Leu Ser Gly Ser Trp 
1               5               



