                         SEQUENCE LISTING

<110>  Phanes Therapeutics, Inc.
 
<120>  Anti-TIM-3 antibodies and uses thereof

<130>  689204.0015/3WO

<150>  US 62/538,277
<151>  2017-07-28

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A Heavy Chain Variable Region

<400>  1

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Val Leu Lys Trp Met 
        35                  40                  45              


Val Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A Light Chain Variable Region

<400>  2

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A Heavy Chain Variable Region

<400>  3

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Val Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ile Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A Light Chain Variable Region

<400>  4

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A Heavy Chain Variable Region

<400>  5

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Glu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A Light Chain Variable Region

<400>  6

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A Heavy Chain Variable Region

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Met Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A Light Chain Variable Region

<400>  8

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Ile His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A Heavy Chain Variable Region

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Arg Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Thr Tyr Asp Ala Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A Light Chain Variable Region

<400>  10

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A Heavy Chain Variable Region

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Asp Tyr Asp Asp Gly His Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A Light Chain Variable Region

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Glu Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Leu Glu Ser Gly Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A Heavy Chain Variable Region

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Asp Val Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A Light Chain Variable Region

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A Heavy Chain Variable Region

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A Light Chain Variable Region

<400>  16

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asp Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A Heavy Chain Variable Region

<400>  17

Asp Val Gln Leu Gln Gly Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Ile Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Tyr Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A Light Chain Variable Region

<400>  18

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys His Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A Heavy Chain Variable Region

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ser Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp His Glu Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A Light Chain Variable Region

<400>  20

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A Heavy Chain Variable Region

<400>  21

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Asp Ser Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Tyr Arg Tyr Asp Gly Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A Light Chain Variable Region

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Ser Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110     


<210>  23
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A Heavy Chain Variable Region

<400>  23

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Asp Ile Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Tyr Arg Tyr Asp Gly Tyr Tyr Ala Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A Light Chain Variable Region

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A Heavy Chain Variable Region

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Ser Tyr Tyr Arg Tyr Thr Gly Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A Light Chain Variable Region

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ala Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Val His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A Heavy Chain Variable Region

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Ser Leu Thr Tyr Asp Gly Tyr Tyr Pro Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A Light Chain Variable Region

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A Heavy Chain Variable Region

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Ser Cys Phe Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Phe Asp Arg Pro Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  30
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A Light Chain Variable Region

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A Heavy Chain Variable Region

<400>  31

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Gly Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Tyr Arg Tyr Asp Tyr Trp Phe Phe Gly Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A Light Chain Variable Region

<400>  32

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Glu Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A Heavy Chain Variable Region

<400>  33

Asp Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ile Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Ser Gly Asn His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A Light Chain Variable Region

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A Heavy Chain Variable Region

<400>  35

Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Glu Asn Phe Asp Tyr Leu Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A Light Chain Variable Region

<400>  36

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Thr Arg Phe Asn Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Arg Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A Heavy Chain Variable Region

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Tyr Tyr Tyr Gly Ser Asp Tyr Val Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A Light Chain Variable Region

<400>  38

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Asp Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A Heavy Chain Variable Region

<400>  39

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Arg Trp Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  40
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A Light Chain Variable Region

<400>  40

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A Heavy Chain Variable Region

<400>  41

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Phe 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Thr Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Tyr Gly Tyr Val Gly Asn Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A Light Chain Variable Region

<400>  42

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn His Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A HC CDR1

<400>  43

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A HC CDR2

<400>  44

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A HC CDR3

<400>  45

Ala Arg Asp Ala Met Asp Tyr 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A HC CDR1

<400>  46

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A HC CDR2

<400>  47

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A HC CDR3

<400>  48

Ala Arg Asp Thr Met Asp Tyr 
1               5           


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A HC CDR1

<400>  49

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A HC CDR2

<400>  50

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A HC CDR3

<400>  51

Ala Arg Asp Leu Glu Asp Tyr 
1               5           


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A CDR1

<400>  52

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A CDR2

<400>  53

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A CDR3

<400>  54

Ala Arg Asp Leu Met Asp Tyr 
1               5           


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A HC CDR1

<400>  55

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A HC CDR2

<400>  56

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A HC CDR3

<400>  57

Ala Arg Ser Tyr Tyr Thr Tyr Asp Ala Ile Asp Tyr 
1               5                   10          


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A HC CDR1

<400>  58

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A HC CDR2

<400>  59

Ile Asn Pro Tyr Asn Asp Val Thr 
1               5               


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A HC CDR3

<400>  60

Ala Arg Ser Ser Asp Tyr Asp Asp Gly His Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A HC CDR1

<400>  61

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A HC CDR2

<400>  62

Ile Tyr Pro Gly Asp Gly Ser Thr 
1               5               


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A HC CDR3

<400>  63

Ala Thr Asp Arg Tyr Asp Val Ala Tyr 
1               5                   


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A HC CDR1

<400>  64

Gly Tyr Thr Phe Thr Ser Ser Asp 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A HC CDR2

<400>  65

Ile Phe Pro Gly Asp Gly Ser Thr 
1               5               


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A HC CDR3

<400>  66

Ala Arg Gly Leu Asp Tyr 
1               5       


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A HC CDR1

<400>  67

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A HC CDR2

<400>  68

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A HC CDR3

<400>  69

Ala Arg Asp Gly Arg Tyr Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A HC CDR1

<400>  70

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A HC CDR2

<400>  71

Ile Asn Pro Ser Thr Gly Tyr Thr 
1               5               


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A HC CDR3

<400>  72

Ala Asn Asp His Glu Gly Gly Phe Ala Tyr 
1               5                   10  


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A HC CDR1

<400>  73

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A HC CDR2

<400>  74

Ile Asp Pro Asn Tyr Asp Ser Thr 
1               5               


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A HC CDR3

<400>  75

Ala Arg Gly Gly His Tyr Arg Tyr Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A HC CDR1

<400>  76

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A HC CDR2

<400>  77

Ile Asp Pro Asn Tyr Asp Ile Thr 
1               5               


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A HC CDR3

<400>  78

Ala Arg Gly Gly His Tyr Arg Tyr Asp Gly Tyr Tyr Ala Leu Asp Tyr 
1               5                   10                  15      


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A HC CDR1

<400>  79

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A HC CDR2

<400>  80

Ile His Pro Gly Ser Gly Gly Thr 
1               5               


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A HC CDR3

<400>  81

Ser Arg Ser Tyr Tyr Arg Tyr Thr Gly Tyr Phe Asp Val 
1               5                   10              


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A HC CDR1

<400>  82

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A HC CDR2

<400>  83

Ile Asp Pro Tyr Tyr Gly Val Thr 
1               5               


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A HC CDR3

<400>  84

Ala Ser Tyr Ser Leu Thr Tyr Asp Gly Tyr Tyr Pro Phe Ala Tyr 
1               5                   10                  15  


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A HC CDR1

<400>  85

Gly Tyr Ser Phe Thr Ala Tyr Tyr 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A HC CDR2

<400>  86

Ile Ser Cys Phe Asn Gly Ala Thr 
1               5               


<210>  87
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A HC CDR3

<400>  87

Ala Arg Arg Gly Asp Phe Asp Arg Pro Glu Phe Ala Tyr 
1               5                   10              


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A HC CDR1

<400>  88

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A HC CDR2

<400>  89

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  90
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A HC CDR3

<400>  90

Ala Ser Asn Tyr Arg Tyr Asp Tyr Trp Phe Phe Gly Val 
1               5                   10              


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A HC CDR1

<400>  91

Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A HC CDR2

<400>  92

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A HC CDR3

<400>  93

Val Ser Gly Asn His Phe Asp Tyr 
1               5               


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A HC CDR1

<400>  94

Gly Tyr Phe Thr Ser Tyr Trp 
1               5           


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A HC CDR2

<400>  95

Ile Asn Pro Ile Thr Gly Tyr Thr 
1               5               


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A HC CDR3

<400>  96

Ala Arg Gly Val Glu Asn Phe Asp Tyr Leu Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A HC CDR1

<400>  97

Gly Phe Thr Phe Ser Asp Phe Tyr 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A HC CDR2

<400>  98

Ile Ser Asp Gly Gly Ser Tyr Thr 
1               5               


<210>  99
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A HC CDR3

<400>  99

Ala Ser Gly Tyr Tyr Tyr Gly Ser Asp Tyr Val Met Asp Tyr 
1               5                   10                  


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A HC CDR1

<400>  100

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A HC CDR2

<400>  101

Ile Ser Ser Gly Ser Ser Thr Ile 
1               5               


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A HC CDR3

<400>  102

Ala Arg Trp Gly Arg Trp Ala Asp Phe Asp Tyr 
1               5                   10      


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A HC CDR1

<400>  103

Gly Phe Ser Leu Thr Gly Phe Gly 
1               5               


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A HC CDR2

<400>  104

Ile Trp Gly Asp Gly Ser Thr 
1               5           


<210>  105
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A HC CDR3

<400>  105

Ala Arg Asp Tyr Tyr Gly Tyr Val Gly Asn Ala Met Asp Tyr 
1               5                   10                  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A LC CDR1

<400>  106

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  107
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A LC CDR2

<400>  107

Lys Val Ser 
1           


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-L10-A LC CDR3

<400>  108

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A LC CDR1

<400>  109

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  110
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A LC CDR2

<400>  110

Lys Val Ser 
1           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-L23-A LC CDR3

<400>  111

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A LC CDR1

<400>  112

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  113
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A LC CDR2

<400>  113

Lys Val Ser 
1           


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-F3-A LC CDR3

<400>  114

Ser Gln Thr Thr His Val Pro Trp Thr 
1               5                   


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A LC CDR1

<400>  115

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  116
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A LC CDR2

<400>  116

Lys Val Ser 
1           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-P15-A LC CDR3

<400>  117

Ser Gln Ser Ile His Val Pro Tyr Thr 
1               5                   


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A LC CDR1

<400>  118

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  119
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A LC CDR2

<400>  119

Trp Ala Ser 
1           


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-N1-A LC CDR3

<400>  120

Lys Gln Ser Tyr Asn Leu Tyr Thr 
1               5               


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A LC CDR1

<400>  121

Gln Ser Val Asp Tyr Asp Gly Glu Ser Tyr 
1               5                   10  


<210>  122
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A LC CDR2

<400>  122

Val Ala Ser 
1           


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-O22-A LC CDR3

<400>  123

Gln Gln Ser Asn Glu Asp Pro Thr Trp Thr 
1               5                   10  


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A LC CDR1

<400>  124

Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210>  125
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A LC CDR2

<400>  125

Gly Thr Ser 
1           


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-L3-A LC CDR3

<400>  126

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A LC CDR1

<400>  127

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A LC CDR2

<400>  128

Arg Ala Asp 
1           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-K5-A LC CDR3

<400>  129

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A LC CDR1

<400>  130

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  131
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A LC CDR2

<400>  131

Ala Ala Ser 
1           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-A14-A LC CDR3

<400>  132

His Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  133
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A LC CDR1

<400>  133

Gln Gly Ile Ser Ser Asn 
1               5       


<210>  134
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A LC CDR2

<400>  134

His Gly Thr 
1           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-K2-A LC CDR3

<400>  135

Val Gln Tyr Ala Gln Phe Pro Phe Thr 
1               5                   


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A LC CDR1

<400>  136

Gln Ser Val Ser Thr Ser Ser Tyr Ser Phe 
1               5                   10  


<210>  137
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A LC CDR2

<400>  137

Tyr Ala Ser 
1           


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-H6-A LC CDR3

<400>  138

Gln His Ser Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A LC CDR1

<400>  139

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  140
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A LC CDR2

<400>  140

Ala Ala Ser 
1           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A19-A LC CDR3

<400>  141

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A LC CDR1

<400>  142

Lys Ser Val Ser Ala Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  143
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A LC CDR2

<400>  143

Leu Ala Ser 
1           


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O15-A LC CDR3

<400>  144

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A LC CDR1

<400>  145

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  146
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A LC CDR2

<400>  146

Leu Ala Ser 
1           


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-I13-A LC CDR3

<400>  147

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A LC CDR1

<400>  148

Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  149
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A LC CDR2

<400>  149

Ala Ala Ser 
1           


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-K4-A LC CDR3

<400>  150

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A LC CDR1

<400>  151

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  152
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A LC CDR2

<400>  152

Ala Glu Ser 
1           


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-G18-A LC CDR3

<400>  153

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A LC CDR1

<400>  154

Gln Asp Ile Asn Arg Tyr 
1               5       


<210>  155
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A LC CDR2

<400>  155

Tyr Thr Ser 
1           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-M21-A LC CDR3

<400>  156

Leu Gln Tyr Asp Asn Leu Leu Phe Thr 
1               5                   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A LC CDR1

<400>  157

Ser Ser Ile Ser Tyr 
1               5   


<210>  158
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A LC CDR2

<400>  158

Asp Thr Ser 
1           


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-M11-A LC CDR3

<400>  159

His Gln Arg Ser Ser Tyr Arg Thr 
1               5               


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A LC CDR1

<400>  160

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  161
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A LC CDR2

<400>  161

Trp Ala Ser 
1           


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-C11-A LC CDR3

<400>  162

Lys Gln Ser Tyr Asn Leu Leu Thr 
1               5               


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A LC CDR1

<400>  163

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10  


<210>  164
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A LC CDR2

<400>  164

Ala Ala Ser 
1           


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-J5-A LC CDR3

<400>  165

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A LC CDR1

<400>  166

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  167
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A LC CDR2

<400>  167

Trp Ala Ser 
1           


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N2-A LC CDR3

<400>  168

Lys Gln Ser Tyr Asn His Met Tyr Thr 
1               5                   


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is Ala, Thr, or Leu

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is Met or Glu

<400>  169

Ala Arg Asp Xaa Xaa Asp Tyr 
1               5           


<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Asn, Thr, or Ser

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is Thr or Ile

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is Trp or Tyr

<400>  170

Ser Gln Xaa Xaa His Val Pro Xaa Thr 
1               5                   


<210>  171
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 Heavy Chain Variable Region

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Gln Ala Thr Leu Ser Thr Asp Lys Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  172
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 Heavy Chain Variable Region

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Gln Ala Thr Leu Ser Thr Asp Leu Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  173
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5 Heavy Chain Variable Region

<400>  173

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Ser Thr Asp Lys Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Asn Leu Asp Ser Val Ser Ala Ala Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Tyr Trp Gly Lys Gly Ser Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  174
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7 Heavy Chain Variable Region

<400>  174

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Ser Thr Asp Lys Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  175
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1 Light Chain Variable Region

<400>  175

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asp Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  176
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L5 Light Chain Variable Region

<400>  176

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asp Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  177
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


