                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
       ANG, SONNY  OON
       LIU, ENLI
       SHPALL, ELIZABETH
       REZVANI, KATY
 
<120>  ENHANCED CHIMERIC ANTIGEN RECEPTORS AND USE THEREOF

<130>  UTFC.P1331WO

<150>  62536934
<151>  2017-07-25

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  1
ctggaagaga agaaaggcaa ttacgtcgtg accgaccacg gcagctgtgt gcgggcttgt       60

ggcgccgata gctacgagat ggaagaggac ggcgtgcgga agtgcaagaa gtgcgagggc      120

ccctgcagaa aagtgtgcaa cggcatcggc atcggagagt tcaaggatag cctgagcatc      180

aacgccacca acatcaagca cttcaagaac tgcaccagca tcagcggcga cctgcacatc      240

ctgcccgtgg cctttagagg cgacagcttc acccacaccc ccccactgga tccccaggaa      300

ctggacatcc tgaaaaccgt gaaagagatc acaggctttc tgctgattca ggcctggccc      360

gagaaccgga cagacctgca cgccttcgag aacctggaaa tcatcagagg ccggaccaag      420

cagcacggcc agttttctct ggccgtggtg tccctgaaca tcaccagcct gggcctgcgg      480

agcctgaaag aaatcagcga cggcgacgtg atcatctccg gcaacaagaa cctgtgctac      540

gccaacacca tcaattggaa gaagctgttc ggcacctccg gccagaaaac aaagatcatc      600

tctaaccggg gcgagaacag ctgcaaagcc accggacaag tgtgccacgc cctgtgtagc      660

cctgagggct gttggggacc cgagcccaga gattgcgtgt cctgccggaa tgtgtccaga      720

ggccgcgagt gcgtggacaa gtgcaacctg ctggaaggcg agccccgcga gtttgtggaa      780

aacagcgagt gcatccagtg ccaccccgag tgtctgcccc aggccatgaa cattacctgc      840

accggcagag gccccgacaa ctgtatccag tgcgcccact acatcgacgg cccccactgc      900

gtgaaaacct gtccagctgg cgtgatggga gagaacaaca ccctcgtgtg gaagtacgcc      960

gacgccggcc atgtgtgcca cctgtgtcac cccaattgca cctacggctg taccggccct     1020

ggcctggaag gctgtcctac caacggcccc aagatccctt ct                        1062


<210>  2
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    50                  55                  60                  


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
65                  70                  75                  80  


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
                85                  90                  95      


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
            100                 105                 110         


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
        115                 120                 125             


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
    130                 135                 140                 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
145                 150                 155                 160 


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
                165                 170                 175     


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
            180                 185                 190         


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
        195                 200                 205             


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
    210                 215                 220                 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
225                 230                 235                 240 


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
                245                 250                 255     


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
            260                 265                 270         


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
        275                 280                 285             


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
    290                 295                 300                 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
305                 310                 315                 320 


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
                325                 330                 335     


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
            340                 345                 350         


Pro Ser 
        


<210>  3
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv

<400>  3
atggagttcg gtttgagctg gctctttctt gttgctatcc tcaagggggt gcagtgttca       60

agggatatcc agatgactca gagccctagc tcccttagcg cgtccgtcgg cgaccgggtt      120

acaattactt gtcgcgcatc acaagacata agtaaatact tgaactggta tcaacaaaag      180

ccaggaaagg ttccaaaact cctcatctat cacacgagta gactccattc cggggtccct      240

gatcggttct caggctctgg ttctggaact gacttcactc tcacgatctc tagtctgcaa      300

cctgaggatg tcgctaccta ttattgccaa cagggaaaca ccctccctta cacatttggc      360

caaggtacca aagttgagat caagaggggc tccacatctg ggagcgggaa accgggaagt      420

ggagaaggct caaccaaagg tgaggtgcaa cttgtagaga gtggtggagg cctggttcag      480

ccgggagggt ccctcagact tagttgcgcg gcttctggcg tttcactgcc ggactacggg      540

gtcagttggg ttaggcaggc gcctgggaaa ggacttgagt ggatcggcgt gatatggggt      600

agtgaaacaa cctactacaa tagtgctctt aaatcaaaat tcattatcag ccgagacaat      660

gctaagaact ccctctatct ccaaatgaat agtcttagag cagaagacac agccgtttat      720

tactgtgccc gccattatta ctatgggggc agctacgcaa tggattattg gggccaaggg      780

accctggtca cggtatcaag c                                                801


<210>  4
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv VL

<400>  4
gatatccaga tgactcagag ccctagctcc cttagcgcgt ccgtcggcga ccgggttaca       60

attacttgtc gcgcatcaca agacataagt aaatacttga actggtatca acaaaagcca      120

ggaaaggttc caaaactcct catctatcac acgagtagac tccattccgg ggtccctgat      180

cggttctcag gctctggttc tggaactgac ttcactctca cgatctctag tctgcaacct      240

gaggatgtcg ctacctatta ttgccaacag ggaaacaccc tcccttacac atttggccaa      300

ggtaccaaag ttgagatcaa gagg                                             324


<210>  5
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv VH

<400>  5
gaggtgcaac ttgtagagag tggtggaggc ctggttcagc cgggagggtc cctcagactt       60

agttgcgcgg cttctggcgt ttcactgccg gactacgggg tcagttgggt taggcaggcg      120

cctgggaaag gacttgagtg gatcggcgtg atatggggta gtgaaacaac ctactacaat      180

agtgctctta aatcaaaatt cattatcagc cgagacaatg ctaagaactc cctctatctc      240

caaatgaata gtcttagagc agaagacaca gccgtttatt actgtgcccg ccattattac      300

tatgggggca gctacgcaat ggattattgg ggccaaggga ccctggtcac ggtatcaagc      360


<210>  6
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv

<400>  6

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv VL

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD19-scFv VH

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv

<400>  9
atggaattcg ggctttcatg gttgttcctc gttgcgatac ttaaaggcgt tcagtgcagt       60

agagacattc agatgaccca aagccctagt agcctctccg ccagtgtggg tgaccgcgtg      120

actattacgt gccgagcaag caagagtatt agcaaagatt tggcatggta ccagcagaaa      180

ccaggcaagg tccctaagtt gcttatatat agcgggtcta cactccaatc tggagtgccg      240

gatcgcttct caggttccgg atcaggaacc gatttcactc ttacaatttc ctctctgcaa      300

ccggaggacg tggcaacata ctattgccag cagcataaca aatatcccta tactttcggt      360

caaggtacaa aagtagaaat aaaacgaggt tccacctccg ggagtgggaa gcccggctcc      420

ggcgaaggat ccaccaaagg cgaggtacag ctcgttgaaa gcgggggcgg tctcgtccaa      480

ccaggagggt ctcttcgact ttcttgtgct gcaagtgggt acacgtttac ttcctattgg      540

atgaattggg ttcggcaagc ccccggtaaa gggcttgaat ggatagggag gatagacccc      600

tacgattctg agacgcatta taatcagaaa ttcaaagata agttcataat aagcagagac      660

aatgcaaaaa atagtttgta cctccagatg aatagtcttc gggcagaaga cacagcggta      720

tattactgtg ctcggggtaa ctgggatgat tactggggtc agggaactct ggttactgtg      780

tctagc                                                                 786


<210>  10
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv VL

<400>  10
gacattcaga tgacccaaag ccctagtagc ctctccgcca gtgtgggtga ccgcgtgact       60

attacgtgcc gagcaagcaa gagtattagc aaagatttgg catggtacca gcagaaacca      120

ggcaaggtcc ctaagttgct tatatatagc gggtctacac tccaatctgg agtgccggat      180

cgcttctcag gttccggatc aggaaccgat ttcactctta caatttcctc tctgcaaccg      240

gaggacgtgg caacatacta ttgccagcag cataacaaat atccctatac tttcggtcaa      300

ggtacaaaag tagaaataaa acga                                             324


<210>  11
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv VH

<400>  11
gaggtacagc tcgttgaaag cgggggcggt ctcgtccaac caggagggtc tcttcgactt       60

tcttgtgctg caagtgggta cacgtttact tcctattgga tgaattgggt tcggcaagcc      120

cccggtaaag ggcttgaatg gatagggagg atagacccct acgattctga gacgcattat      180

aatcagaaat tcaaagataa gttcataata agcagagaca atgcaaaaaa tagtttgtac      240

ctccagatga atagtcttcg ggcagaagac acagcggtat attactgtgc tcggggtaac      300

tgggatgatt actggggtca gggaactctg gttactgtgt ctagc                      345


<210>  12
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv

<400>  12

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Asn Lys Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn 
        195                 200                 205             


Gln Lys Phe Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser 
            260         


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv VL

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD123-scFv VH

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  15
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv

<400>  15
atggagttcg gcctttcttg gctgtttttg gtcgcaatat tgaagggcgt tcagtgttca       60

agggacatac agatgacgca gtcacctagc tctctttcag cctctgtggg agaccgcgtt      120

acaattacgt gttctgcttc tagttcagtg tcttacatgc attggtacca gcaaaaaccc      180

ggcaaggttc caaagctcct tatatacgat acgtccaaac tggcttcagg cgtgccagac      240

aggtttagtg gatctgggag cggcactgac ttcacactta caatatccag tctgcaaccc      300

gaagatgttg cgacatacta ttgtcagcaa tggagcggct atccgctcac cggacagggg      360

acaaaagtgg agataaagcg gggctccacc agtggttccg ggaagcctgg tagtggtgag      420

ggttctacga aaggcgaagt gcagttggtg gagtctggtg gcgggcttgt tcaacccggt      480

ggttctctca ggcttagctg tgcagcctct gggtacacaa tgaattgggt aaggcaagcg      540

cctggaaagg gccttgagtg gatcggtttg ataaccccat acaacggagc ttcaagttac      600

aaccaaaagt tccgcgggaa gtttattata agcagggata acgcaaagaa cagcctctat      660

cttcaaatga actcactccg ggctgaagac acagccgtct attattgtgc ccgggggggc      720

tacgacggac gagggttcga ttactggggt cagggcacac tcgtgaccgt gtcaagc         777


<210>  16
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv VL

<400>  16
gacatacaga tgacgcagtc acctagctct ctttcagcct ctgtgggaga ccgcgttaca       60

attacgtgtt ctgcttctag ttcagtgtct tacatgcatt ggtaccagca aaaacccggc      120

aaggttccaa agctccttat atacgatacg tccaaactgg cttcaggcgt gccagacagg      180

tttagtggat ctgggagcgg cactgacttc acacttacaa tatccagtct gcaacccgaa      240

gatgttgcga catactattg tcagcaatgg agcggctatc cgctcaccgg acaggggaca      300

aaagtggaga taaagcgg                                                    318


<210>  17
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv VH

<400>  17
gaagtgcagt tggtggagtc tggtggcggg cttgttcaac ccggtggttc tctcaggctt       60

agctgtgcag cctctgggta cacaatgaat tgggtaaggc aagcgcctgg aaagggcctt      120

gagtggatcg gtttgataac cccatacaac ggagcttcaa gttacaacca aaagttccgc      180

gggaagttta ttataagcag ggataacgca aagaacagcc tctatcttca aatgaactca      240

ctccgggctg aagacacagc cgtctattat tgtgcccggg ggggctacga cggacgaggg      300

ttcgattact ggggtcaggg cacactcgtg accgtgtcaa gc                         342


<210>  18
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv

<400>  18

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Gly Tyr Pro Leu Thr Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
        115                 120                 125             


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
    130                 135                 140                 


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Met Asn Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Leu Ile Thr 
            180                 185                 190         


Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Phe 
        195                 200                 205             


Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly 
225                 230                 235                 240 


Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv VL

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Leu Thr 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105     


<210>  20
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hMeso-scFv VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Met Asn Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Leu Ile Thr Pro 
        35                  40                  45              


Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Phe Ile 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
65                  70                  75                  80  


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr 
                85                  90                  95      


Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  21
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv

<400>  21
atggagttcg gacttagttg gcttttcctc gtcgccatac tcaaaggtgt acaatgctca       60

cgcgatatac aaatgacgca gagtccatcc tcactgtctg cctcagtagg cgacagggtc      120

acaataacct gtaaagcaag cccggatatc aactcttacc tcagttggtt ccaacagaaa      180

ccaggaaagg tgccgaagtt gttgatttac cgcgcaaacc gcctcgttga cggcgtgcca      240

gataggtttt ctggcagcgg gagcggcact gactttacgc tcactatatc aagcctgcag      300

ccggaggacg tagcaactta ctattgcctc caatacgacg aattccctta cacgttcggg      360

caaggaacta aagttgaaat aaaaagagga agcacaagtg gttctggaaa acccggttcc      420

ggtgagggca gtaccaaagg agaggtgcag ttggtagagt ctggtggggg tttggtgcaa      480

cccggagggt ctctgaggtt gtcttgcgcg gcatccggct ttactttttc ctcatatgcg      540

atgtcatggg tacgacaggc cccaggcaag ggactggagt ggatcgcatc tatttcacga      600

ggagggacga catattaccc ggattcagtg aagggcaaat tcataatttc acgcgataac      660

gccaagaact ccctctacct gcaaatgaac agtcttagag cggaagatac ggctgtgtat      720

tactgtgcgc gatatgacta cgatggatat tacgcgatgg attattgggg acaaggtaca      780

ctggtaaccg tttccagc                                                    798


<210>  22
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv VL

<400>  22
gatatacaaa tgacgcagag tccatcctca ctgtctgcct cagtaggcga cagggtcaca       60

ataacctgta aagcaagccc ggatatcaac tcttacctca gttggttcca acagaaacca      120

ggaaaggtgc cgaagttgtt gatttaccgc gcaaaccgcc tcgttgacgg cgtgccagat      180

aggttttctg gcagcgggag cggcactgac tttacgctca ctatatcaag cctgcagccg      240

gaggacgtag caacttacta ttgcctccaa tacgacgaat tcccttacac gttcgggcaa      300

ggaactaaag ttgaaataaa aaga                                             324


<210>  23
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv VH

<400>  23
gaggtgcagt tggtagagtc tggtgggggt ttggtgcaac ccggagggtc tctgaggttg       60

tcttgcgcgg catccggctt tactttttcc tcatatgcga tgtcatgggt acgacaggcc      120

ccaggcaagg gactggagtg gatcgcatct atttcacgag gagggacgac atattacccg      180

gattcagtga agggcaaatt cataatttca cgcgataacg ccaagaactc cctctacctg      240

caaatgaaca gtcttagagc ggaagatacg gctgtgtatt actgtgcgcg atatgactac      300

gatggatatt acgcgatgga ttattgggga caaggtacac tggtaaccgt ttccagc         357


<210>  24
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv

<400>  24

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Pro 
        35                  40                  45              


Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Ala Ser Ile Ser Arg Gly Gly Thr Thr Tyr Tyr Pro Asp 
        195                 200                 205             


Ser Val Lys Gly Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Tyr Asp Tyr Asp Gly Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265     


<210>  25
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Pro Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hROR1-scFv VH

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ser Ile Ser Arg Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv

<400>  27
atggagttcg gtctcagttg gctgtttttg gttgctatct tgaagggcgt ccaatgcagc       60

cgggacatcc agatgaccca gtctccctct agcatgtcag cgagtcttgg tgatcgagtg      120

acgattacct gcagagcctc tcaagatata aacagctatc tttcatggtt ccaacagaag      180

ccggggaagt ccccaaaaac tctcatatac agggcgaatc gactcgtaga cggtgtgcct      240

tcaaggtttt ccgggagtgg tagtggcaca gattacacac ttacaatctc ttcattgcag      300

tatgaggatt tcgggatcta ctactgtcaa cagtacgacg aatccccatg gacgtttggg      360

ggcgggacca aacttgagat aaaagggagc acatctggaa gtggtaaacc tgggtcaggg      420

gagggttcca caaaaggaca aattcaactt gtccaaagcg gtcctggtct taagaagcct      480

ggagggtctg tcaggataag ttgtgcggca tccggctaca ccttcaccaa ctatgggatg      540

aactgggtga aacaagcgcc tgggaaaggt cttcgatgga tgggctggat taatacccac      600

actggagagc ccacttacgc tgatgatttc aaaggacgat ttaccttctc cttggatact      660

tccaagagta ccgcgtactt gcaaatcaac agtctccggg ctgaagacac ggccacatac      720

ttctgtacgc ggagagggta tgactggtat tttgatgtgt ggggtcaggg aacaaccgtg      780

actgtttcaa gc                                                          792


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv VL

<400>  28
gacatccaga tgacccagtc tccctctagc atgtcagcga gtcttggtga tcgagtgacg       60

attacctgca gagcctctca agatataaac agctatcttt catggttcca acagaagccg      120

gggaagtccc caaaaactct catatacagg gcgaatcgac tcgtagacgg tgtgccttca      180

aggttttccg ggagtggtag tggcacagat tacacactta caatctcttc attgcagtat      240

gaggatttcg ggatctacta ctgtcaacag tacgacgaat ccccatggac gtttgggggc      300

gggaccaaac ttgagataaa a                                                321


<210>  29
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv VH

<400>  29
caaattcaac ttgtccaaag cggtcctggt cttaagaagc ctggagggtc tgtcaggata       60

agttgtgcgg catccggcta caccttcacc aactatggga tgaactgggt gaaacaagcg      120

cctgggaaag gtcttcgatg gatgggctgg attaataccc acactggaga gcccacttac      180

gctgatgatt tcaaaggacg atttaccttc tccttggata cttccaagag taccgcgtac      240

ttgcaaatca acagtctccg ggctgaagac acggccacat acttctgtac gcggagaggg      300

tatgactggt attttgatgt gtggggtcag ggaacaaccg tgactgtttc aagc            354


<210>  30
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv

<400>  30

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Tyr Glu Asp Phe Gly Ile Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asp Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Gly Leu Lys Lys Pro 
145                 150                 155                 160 


Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Arg 
            180                 185                 190         


Trp Met Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr Ala Asp 
        195                 200                 205             


Asp Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Thr Arg Arg Gly Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser 
            260                 


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv VL

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Tyr 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Tyr Tyr Cys Gln Gln Tyr Asp Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD5-scFv VH

<400>  32

Gln Ile Gln Leu Val Gln Ser Gly Pro Gly Leu Lys Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Arg Arg Gly Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  33
<211>  10253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD19-CAR

<400>  33
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggtt tgagctggct ctttcttgtt     3180

gctatcctca agggggtgca gtgttcaagg gatatccaga tgactcagag ccctagctcc     3240

cttagcgcgt ccgtcggcga ccgggttaca attacttgtc gcgcatcaca agacataagt     3300

aaatacttga actggtatca acaaaagcca ggaaaggttc caaaactcct catctatcac     3360

acgagtagac tccattccgg ggtccctgat cggttctcag gctctggttc tggaactgac     3420

ttcactctca cgatctctag tctgcaacct gaggatgtcg ctacctatta ttgccaacag     3480

ggaaacaccc tcccttacac atttggccaa ggtaccaaag ttgagatcaa gaggggctcc     3540

acatctggga gcgggaaacc gggaagtgga gaaggctcaa ccaaaggtga ggtgcaactt     3600

gtagagagtg gtggaggcct ggttcagccg ggagggtccc tcagacttag ttgcgcggct     3660

tctggcgttt cactgccgga ctacggggtc agttgggtta ggcaggcgcc tgggaaagga     3720

cttgagtgga tcggcgtgat atggggtagt gaaacaacct actacaatag tgctcttaaa     3780

tcaaaattca ttatcagccg agacaatgct aagaactccc tctatctcca aatgaatagt     3840

cttagagcag aagacacagc cgtttattac tgtgcccgcc attattacta tgggggcagc     3900

tacgcaatgg attattgggg ccaagggacc ctggtcacgg tatcaagcta cgtcaccgtc     3960

tcttcacagg atcccgccga gcccaaatct cctgacaaaa ctcacacatg cccaccgtgc     4020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     4080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     4140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     4200

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     4260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     4320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     4380

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     4440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca accggagaac     4500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     4560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     4620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaaaaagat     4680

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta     4740

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac     4800

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     4860

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     4920

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     4980

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     5040

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     5100

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     5160

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     5220

cctcgcggac cgcagtgtac taattatgct ctcttgaaat tggctggaga tgttgagagc     5280

aatcccgggc ccatgcggat cagcaagccc cacctgcgga gcatcagcat ccagtgctac     5340

ctgtgcctgc tgctgaacag ccacttcctg accgaggccg gcatccacgt gttcatcctg     5400

ggctgcttca gcgccggact gcccaagacc gaggccaact gggtgaacgt gatcagcgac     5460

ctgaagaaga tcgaggacct gatccagagc atgcacatcg acgccaccct gtacaccgag     5520

agcgacgtgc accccagctg caaggtgacc gccatgaagt gctttctgct ggaactgcag     5580

gtgatcagcc tggaaagcgg cgacgccagc atccacgaca ccgtggagaa cctgatcatc     5640

ctggccaaca acagcctgag cagcaacggc aacgtgaccg agagcggctg caaagagtgc     5700

gaggaactgg aagagaagaa catcaaagag tttctgcaga gcttcgtgca catcgtgcag     5760

atgttcatca acaccagctg acgcgtcatc atcgatccgg attagtccaa tttgttaaag     5820

acaggatatc agtggtccag gctctagttt tgactcaaca atatcaccag ctgaagccta     5880

tagagtacga gccatagata aaataaaaga ttttatttag tctccagaaa aaggggggaa     5940

tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat     6000

ggaaaaatac ataactgaga atagagaagt tcagatcaag gtcaggaaca gatggaacag     6060

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa     6120

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc     6180

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag     6240

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg     6300

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctcaat     6360

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg     6420

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct     6480

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca cacatgcagc     6540

atgtatcaaa attaatttgg ttttttttct taagtattta cattaaatgg ccatagtact     6600

taaagttaca ttggcttcct tgaaataaac atggagtatt cagaatgtgt cataaatatt     6660

tctaatttta agatagtatc tccattggct ttctactttt tcttttattt ttttttgtcc     6720

tctgtcttcc atttgttgtt gttgttgttt gtttgtttgt ttgttggttg gttggttaat     6780

ttttttttaa agatcctaca ctatagttca agctagacta ttagctactc tgtaacccag     6840

ggtgaccttg aagtcatggg tagcctgctg ttttagcctt cccacatcta agattacagg     6900

tatgagctat catttttggt atattgattg attgattgat tgatgtgtgt gtgtgtgatt     6960

gtgtttgtgt gtgtgactgt gaaaatgtgt gtatgggtgt gtgtgaatgt gtgtatgtat     7020

gtgtgtgtgt gagtgtgtgt gtgtgtgtgt gcatgtgtgt gtgtgtgact gtgtctatgt     7080

gtatgactgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgaa     7140

aaaatattct atggtagtga gagccaacgc tccggctcag gtgtcaggtt ggtttttgag     7200

acagagtctt tcacttagct tggaattcac tggccgtcgt tttacaacgt cgtgactggg     7260

aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc     7320

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg     7380

aatggcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat     7440

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     7500

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     7560

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     7620

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     7680

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     7740

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     7800

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     7860

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     7920

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     7980

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     8040

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     8100

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     8160

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     8220

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     8280

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     8340

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     8400

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     8460

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     8520

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     8580

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     8640

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     8700

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     8760

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     8820

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     8880

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     8940

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     9000

ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     9060

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     9120

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     9180

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     9240

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     9300

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     9360

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     9420

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     9480

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     9540

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     9600

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     9660

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc     9720

gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc     9780

ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct     9840

atgaccatga ttacgccaag ctttgctctt aggagtttcc taatacatcc caaactcaaa     9900

tatataaagc atttgacttg ttctatgccc tagggggcgg ggggaagcta agccagcttt     9960

ttttaacatt taaaatgtta attccatttt aaatgcacag atgtttttat ttcataaggg    10020

tttcaatgtg catgaatgct gcaatattcc tgttaccaaa gctagtataa ataaaaatag    10080

ataaacgtgg aaattactta gagtttctgt cattaacgtt tccttcctca gttgacaaca    10140

taaatgcgct gctgagcaag ccagtttgca tctgtcagga tcaatttccc attatgccag    10200

tcatattaat tactagtcaa ttagttgatt tttatttttg acatatacat gtg           10253


<210>  34
<211>  10238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD123-CAR

<400>  34
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gaattcgggc tttcatggtt gttcctcgtt     3180

gcgatactta aaggcgttca gtgcagtaga gacattcaga tgacccaaag ccctagtagc     3240

ctctccgcca gtgtgggtga ccgcgtgact attacgtgcc gagcaagcaa gagtattagc     3300

aaagatttgg catggtacca gcagaaacca ggcaaggtcc ctaagttgct tatatatagc     3360

gggtctacac tccaatctgg agtgccggat cgcttctcag gttccggatc aggaaccgat     3420

ttcactctta caatttcctc tctgcaaccg gaggacgtgg caacatacta ttgccagcag     3480

cataacaaat atccctatac tttcggtcaa ggtacaaaag tagaaataaa acgaggttcc     3540

acctccggga gtgggaagcc cggctccggc gaaggatcca ccaaaggcga ggtacagctc     3600

gttgaaagcg ggggcggtct cgtccaacca ggagggtctc ttcgactttc ttgtgctgca     3660

agtgggtaca cgtttacttc ctattggatg aattgggttc ggcaagcccc cggtaaaggg     3720

cttgaatgga tagggaggat agacccctac gattctgaga cgcattataa tcagaaattc     3780

aaagataagt tcataataag cagagacaat gcaaaaaata gtttgtacct ccagatgaat     3840

agtcttcggg cagaagacac agcggtatat tactgtgctc ggggtaactg ggatgattac     3900

tggggtcagg gaactctggt tactgtgtct agctacgtca ccgtctcttc acaggatccc     3960

gccgagccca aatctcctga caaaactcac acatgcccac cgtgcccagc acctgaactc     4020

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     4080

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     4140

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     4200

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     4260

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     4320

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     4380

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     4440

agcgacatcg ccgtggagtg ggagagcaat gggcaaccgg agaacaacta caagaccacg     4500

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     4560

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     4620

cactacacgc agaagagcct ctccctgtct ccgggtaaaa aagatcccaa attttgggtg     4680

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     4740

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     4800

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     4860

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     4920

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     4980

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     5040

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     5100

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     5160

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg cggaccgcag     5220

tgtactaatt atgctctctt gaaattggct ggagatgttg agagcaatcc cgggcccatg     5280

cggatcagca agccccacct gcggagcatc agcatccagt gctacctgtg cctgctgctg     5340

aacagccact tcctgaccga ggccggcatc cacgtgttca tcctgggctg cttcagcgcc     5400

ggactgccca agaccgaggc caactgggtg aacgtgatca gcgacctgaa gaagatcgag     5460

gacctgatcc agagcatgca catcgacgcc accctgtaca ccgagagcga cgtgcacccc     5520

agctgcaagg tgaccgccat gaagtgcttt ctgctggaac tgcaggtgat cagcctggaa     5580

agcggcgacg ccagcatcca cgacaccgtg gagaacctga tcatcctggc caacaacagc     5640

ctgagcagca acggcaacgt gaccgagagc ggctgcaaag agtgcgagga actggaagag     5700

aagaacatca aagagtttct gcagagcttc gtgcacatcg tgcagatgtt catcaacacc     5760

agctgacgcg tcatcatcga tccggattag tccaatttgt taaagacagg atatcagtgg     5820

tccaggctct agttttgact caacaatatc accagctgaa gcctatagag tacgagccat     5880

agataaaata aaagatttta tttagtctcc agaaaaaggg gggaatgaaa gaccccacct     5940

gtaggtttgg caagctagct taagtaacgc cattttgcaa ggcatggaaa aatacataac     6000

tgagaataga gaagttcaga tcaaggtcag gaacagatgg aacagctgaa tatgggccaa     6060

acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggaacag     6120

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa     6180

gaacagatgg tccccagatg cggtccagcc ctcagcagtt tctagagaac catcagatgt     6240

ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta accaatcagt     6300

tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tcaataaaag agcccacaac     6360

ccctcactcg gggcgccagt cctccgattg actgagtcgc ccgggtaccc gtgtatccaa     6420

taaaccctct tgcagttgca tccgacttgt ggtctcgctg ttccttggga gggtctcctc     6480

tgagtgattg actacccgtc agcgggggtc tttcacacat gcagcatgta tcaaaattaa     6540

tttggttttt tttcttaagt atttacatta aatggccata gtacttaaag ttacattggc     6600

ttccttgaaa taaacatgga gtattcagaa tgtgtcataa atatttctaa ttttaagata     6660

gtatctccat tggctttcta ctttttcttt tatttttttt tgtcctctgt cttccatttg     6720

ttgttgttgt tgtttgtttg tttgtttgtt ggttggttgg ttaatttttt tttaaagatc     6780

ctacactata gttcaagcta gactattagc tactctgtaa cccagggtga ccttgaagtc     6840

atgggtagcc tgctgtttta gccttcccac atctaagatt acaggtatga gctatcattt     6900

ttggtatatt gattgattga ttgattgatg tgtgtgtgtg tgattgtgtt tgtgtgtgtg     6960

actgtgaaaa tgtgtgtatg ggtgtgtgtg aatgtgtgta tgtatgtgtg tgtgtgagtg     7020

tgtgtgtgtg tgtgtgcatg tgtgtgtgtg tgactgtgtc tatgtgtatg actgtgtgtg     7080

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt gtgaaaaaat attctatggt     7140

agtgagagcc aacgctccgg ctcaggtgtc aggttggttt ttgagacaga gtctttcact     7200

tagcttggaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta     7260

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg     7320

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgcctgatgc     7380

ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta     7440

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg     7500

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     7560

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     7620

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     7680

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     7740

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa     7800

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     7860

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     7920

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     7980

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     8040

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     8100

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     8160

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     8220

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     8280

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     8340

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     8400

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     8460

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     8520

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     8580

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     8640

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     8700

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     8760

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     8820

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     8880

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     8940

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc     9000

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     9060

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     9120

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     9180

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     9240

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     9300

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     9360

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     9420

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     9480

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     9540

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     9600

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     9660

gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg     9720

tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt     9780

tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg     9840

ccaagctttg ctcttaggag tttcctaata catcccaaac tcaaatatat aaagcatttg     9900

acttgttcta tgccctaggg ggcgggggga agctaagcca gcttttttta acatttaaaa     9960

tgttaattcc attttaaatg cacagatgtt tttatttcat aagggtttca atgtgcatga    10020

atgctgcaat attcctgtta ccaaagctag tataaataaa aatagataaa cgtggaaatt    10080

acttagagtt tctgtcatta acgtttcctt cctcagttga caacataaat gcgctgctga    10140

gcaagccagt ttgcatctgt caggatcaat ttcccattat gccagtcata ttaattacta    10200

gtcaattagt tgatttttat ttttgacata tacatgtg                            10238


<210>  35
<211>  10229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMeso-CAR

<400>  35
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggcc tttcttggct gtttttggtc     3180

gcaatattga agggcgttca gtgttcaagg gacatacaga tgacgcagtc acctagctct     3240

ctttcagcct ctgtgggaga ccgcgttaca attacgtgtt ctgcttctag ttcagtgtct     3300

tacatgcatt ggtaccagca aaaacccggc aaggttccaa agctccttat atacgatacg     3360

tccaaactgg cttcaggcgt gccagacagg tttagtggat ctgggagcgg cactgacttc     3420

acacttacaa tatccagtct gcaacccgaa gatgttgcga catactattg tcagcaatgg     3480

agcggctatc cgctcaccgg acaggggaca aaagtggaga taaagcgggg ctccaccagt     3540

ggttccggga agcctggtag tggtgagggt tctacgaaag gcgaagtgca gttggtggag     3600

tctggtggcg ggcttgttca acccggtggt tctctcaggc ttagctgtgc agcctctggg     3660

tacacaatga attgggtaag gcaagcgcct ggaaagggcc ttgagtggat cggtttgata     3720

accccataca acggagcttc aagttacaac caaaagttcc gcgggaagtt tattataagc     3780

agggataacg caaagaacag cctctatctt caaatgaact cactccgggc tgaagacaca     3840

gccgtctatt attgtgcccg ggggggctac gacggacgag ggttcgatta ctggggtcag     3900

ggcacactcg tgaccgtgtc aagctacgtc accgtctctt cacaggatcc cgccgagccc     3960

aaatctcctg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     4020

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     4080

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     4140

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     4200

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     4260

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     4320

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     4380

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     4440

gccgtggagt gggagagcaa tgggcaaccg gagaacaact acaagaccac gcctcccgtg     4500

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     4560

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     4620

cagaagagcc tctccctgtc tccgggtaaa aaagatccca aattttgggt gctggtggtg     4680

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     4740

gtgaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     4800

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     4860

cgctccagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     4920

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     4980

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     5040

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     5100

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     5160

gacacctacg acgcccttca catgcaggcc ctgccccctc gcggaccgca gtgtactaat     5220

tatgctctct tgaaattggc tggagatgtt gagagcaatc ccgggcccat gcggatcagc     5280

aagccccacc tgcggagcat cagcatccag tgctacctgt gcctgctgct gaacagccac     5340

ttcctgaccg aggccggcat ccacgtgttc atcctgggct gcttcagcgc cggactgccc     5400

aagaccgagg ccaactgggt gaacgtgatc agcgacctga agaagatcga ggacctgatc     5460

cagagcatgc acatcgacgc caccctgtac accgagagcg acgtgcaccc cagctgcaag     5520

gtgaccgcca tgaagtgctt tctgctggaa ctgcaggtga tcagcctgga aagcggcgac     5580

gccagcatcc acgacaccgt ggagaacctg atcatcctgg ccaacaacag cctgagcagc     5640

aacggcaacg tgaccgagag cggctgcaaa gagtgcgagg aactggaaga gaagaacatc     5700

aaagagtttc tgcagagctt cgtgcacatc gtgcagatgt tcatcaacac cagctgacgc     5760

gtcatcatcg atccggatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc     5820

tagttttgac tcaacaatat caccagctga agcctataga gtacgagcca tagataaaat     5880

aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc tgtaggtttg     5940

gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa ctgagaatag     6000

agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca aacaggatat     6060

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca gctgaatatg     6120

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg     6180

gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg tttccagggt     6240

gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc     6300

gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa cccctcactc     6360

ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca ataaaccctc     6420

ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct ctgagtgatt     6480

gactacccgt cagcgggggt ctttcacaca tgcagcatgt atcaaaatta atttggtttt     6540

ttttcttaag tatttacatt aaatggccat agtacttaaa gttacattgg cttccttgaa     6600

ataaacatgg agtattcaga atgtgtcata aatatttcta attttaagat agtatctcca     6660

ttggctttct actttttctt ttattttttt ttgtcctctg tcttccattt gttgttgttg     6720

ttgtttgttt gtttgtttgt tggttggttg gttaattttt ttttaaagat cctacactat     6780

agttcaagct agactattag ctactctgta acccagggtg accttgaagt catgggtagc     6840

ctgctgtttt agccttccca catctaagat tacaggtatg agctatcatt tttggtatat     6900

tgattgattg attgattgat gtgtgtgtgt gtgattgtgt ttgtgtgtgt gactgtgaaa     6960

atgtgtgtat gggtgtgtgt gaatgtgtgt atgtatgtgt gtgtgtgagt gtgtgtgtgt     7020

gtgtgtgcat gtgtgtgtgt gtgactgtgt ctatgtgtat gactgtgtgt gtgtgtgtgt     7080

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tgtgaaaaaa tattctatgg tagtgagagc     7140

caacgctccg gctcaggtgt caggttggtt tttgagacag agtctttcac ttagcttgga     7200

attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta     7260

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg     7320

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcctgatg cggtattttc     7380

tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct     7440

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     7500

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     7560

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     7620

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     7680

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     7740

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     7800

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     7860

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     7920

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     7980

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     8040

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     8100

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     8160

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     8220

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     8280

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     8340

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     8400

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     8460

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     8520

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     8580

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     8640

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     8700

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     8760

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     8820

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     8880

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     8940

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     9000

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     9060

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     9120

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     9180

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     9240

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     9300

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     9360

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     9420

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     9480

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     9540

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     9600

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     9660

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc     9720

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa     9780

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagcttt     9840

gctcttagga gtttcctaat acatcccaaa ctcaaatata taaagcattt gacttgttct     9900

atgccctagg gggcgggggg aagctaagcc agcttttttt aacatttaaa atgttaattc     9960

cattttaaat gcacagatgt ttttatttca taagggtttc aatgtgcatg aatgctgcaa    10020

tattcctgtt accaaagcta gtataaataa aaatagataa acgtggaaat tacttagagt    10080

ttctgtcatt aacgtttcct tcctcagttg acaacataaa tgcgctgctg agcaagccag    10140

tttgcatctg tcaggatcaa tttcccatta tgccagtcat attaattact agtcaattag    10200

ttgattttta tttttgacat atacatgtg                                      10229


<210>  36
<211>  10250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hROR1-CAR

<400>  36
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggac ttagttggct tttcctcgtc     3180

gccatactca aaggtgtaca atgctcacgc gatatacaaa tgacgcagag tccatcctca     3240

ctgtctgcct cagtaggcga cagggtcaca ataacctgta aagcaagccc ggatatcaac     3300

tcttacctca gttggttcca acagaaacca ggaaaggtgc cgaagttgtt gatttaccgc     3360

gcaaaccgcc tcgttgacgg cgtgccagat aggttttctg gcagcgggag cggcactgac     3420

tttacgctca ctatatcaag cctgcagccg gaggacgtag caacttacta ttgcctccaa     3480

tacgacgaat tcccttacac gttcgggcaa ggaactaaag ttgaaataaa aagaggaagc     3540

acaagtggtt ctggaaaacc cggttccggt gagggcagta ccaaaggaga ggtgcagttg     3600

gtagagtctg gtgggggttt ggtgcaaccc ggagggtctc tgaggttgtc ttgcgcggca     3660

tccggcttta ctttttcctc atatgcgatg tcatgggtac gacaggcccc aggcaaggga     3720

ctggagtgga tcgcatctat ttcacgagga gggacgacat attacccgga ttcagtgaag     3780

ggcaaattca taatttcacg cgataacgcc aagaactccc tctacctgca aatgaacagt     3840

cttagagcgg aagatacggc tgtgtattac tgtgcgcgat atgactacga tggatattac     3900

gcgatggatt attggggaca aggtacactg gtaaccgttt ccagctacgt caccgtctct     3960

tcacaggatc ccgccgagcc caaatctcct gacaaaactc acacatgccc accgtgccca     4020

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     4080

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     4140

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     4200

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     4260

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     4320

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     4380

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     4440

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcaacc ggagaacaac     4500

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     4560

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     4620

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa aaaagatccc     4680

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     4740

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     4800

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     4860

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     4920

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     4980

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     5040

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     5100

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     5160

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     5220

cgcggaccgc agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaat     5280

cccgggccca tgcggatcag caagccccac ctgcggagca tcagcatcca gtgctacctg     5340

tgcctgctgc tgaacagcca cttcctgacc gaggccggca tccacgtgtt catcctgggc     5400

tgcttcagcg ccggactgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg     5460

aagaagatcg aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc     5520

gacgtgcacc ccagctgcaa ggtgaccgcc atgaagtgct ttctgctgga actgcaggtg     5580

atcagcctgg aaagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg     5640

gccaacaaca gcctgagcag caacggcaac gtgaccgaga gcggctgcaa agagtgcgag     5700

gaactggaag agaagaacat caaagagttt ctgcagagct tcgtgcacat cgtgcagatg     5760

ttcatcaaca ccagctgacg cgtcatcatc gatccggatt agtccaattt gttaaagaca     5820

ggatatcagt ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag     5880

agtacgagcc atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga     5940

aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga     6000

aaaatacata actgagaata gagaagttca gatcaaggtc aggaacagat ggaacagctg     6060

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     6120

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     6180

gctcagggcc aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga     6240

accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac     6300

taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctcaataaa     6360

agagcccaca acccctcact cggggcgcca gtcctccgat tgactgagtc gcccgggtac     6420

ccgtgtatcc aataaaccct cttgcagttg catccgactt gtggtctcgc tgttccttgg     6480

gagggtctcc tctgagtgat tgactacccg tcagcggggg tctttcacac atgcagcatg     6540

tatcaaaatt aatttggttt tttttcttaa gtatttacat taaatggcca tagtacttaa     6600

agttacattg gcttccttga aataaacatg gagtattcag aatgtgtcat aaatatttct     6660

aattttaaga tagtatctcc attggctttc tactttttct tttatttttt tttgtcctct     6720

gtcttccatt tgttgttgtt gttgtttgtt tgtttgtttg ttggttggtt ggttaatttt     6780

tttttaaaga tcctacacta tagttcaagc tagactatta gctactctgt aacccagggt     6840

gaccttgaag tcatgggtag cctgctgttt tagccttccc acatctaaga ttacaggtat     6900

gagctatcat ttttggtata ttgattgatt gattgattga tgtgtgtgtg tgtgattgtg     6960

tttgtgtgtg tgactgtgaa aatgtgtgta tgggtgtgtg tgaatgtgtg tatgtatgtg     7020

tgtgtgtgag tgtgtgtgtg tgtgtgtgca tgtgtgtgtg tgtgactgtg tctatgtgta     7080

tgactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa     7140

atattctatg gtagtgagag ccaacgctcc ggctcaggtg tcaggttggt ttttgagaca     7200

gagtctttca cttagcttgg aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa     7260

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     7320

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     7380

ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     7440

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     7500

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     7560

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     7620

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     7680

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     7740

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     7800

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     7860

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     7920

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     7980

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     8040

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     8100

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     8160

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     8220

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     8280

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     8340

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     8400

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     8460

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     8520

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     8580

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     8640

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     8700

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     8760

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     8820

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     8880

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     8940

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     9000

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     9060

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     9120

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     9180

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     9240

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     9300

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     9360

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     9420

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     9480

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     9540

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     9600

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     9660

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     9720

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc     9780

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg     9840

accatgatta cgccaagctt tgctcttagg agtttcctaa tacatcccaa actcaaatat     9900

ataaagcatt tgacttgttc tatgccctag ggggcggggg gaagctaagc cagctttttt     9960

taacatttaa aatgttaatt ccattttaaa tgcacagatg tttttatttc ataagggttt    10020

caatgtgcat gaatgctgca atattcctgt taccaaagct agtataaata aaaatagata    10080

aacgtggaaa ttacttagag tttctgtcat taacgtttcc ttcctcagtt gacaacataa    10140

atgcgctgct gagcaagcca gtttgcatct gtcaggatca atttcccatt atgccagtca    10200

tattaattac tagtcaatta gttgattttt atttttgaca tatacatgtg               10250


<210>  37
<211>  10244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCD5-CAR

<400>  37
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggtc tcagttggct gtttttggtt     3180

gctatcttga agggcgtcca atgcagccgg gacatccaga tgacccagtc tccctctagc     3240

atgtcagcga gtcttggtga tcgagtgacg attacctgca gagcctctca agatataaac     3300

agctatcttt catggttcca acagaagccg gggaagtccc caaaaactct catatacagg     3360

gcgaatcgac tcgtagacgg tgtgccttca aggttttccg ggagtggtag tggcacagat     3420

tacacactta caatctcttc attgcagtat gaggatttcg ggatctacta ctgtcaacag     3480

tacgacgaat ccccatggac gtttgggggc gggaccaaac ttgagataaa agggagcaca     3540

tctggaagtg gtaaacctgg gtcaggggag ggttccacaa aaggacaaat tcaacttgtc     3600

caaagcggtc ctggtcttaa gaagcctgga gggtctgtca ggataagttg tgcggcatcc     3660

ggctacacct tcaccaacta tgggatgaac tgggtgaaac aagcgcctgg gaaaggtctt     3720

cgatggatgg gctggattaa tacccacact ggagagccca cttacgctga tgatttcaaa     3780

ggacgattta ccttctcctt ggatacttcc aagagtaccg cgtacttgca aatcaacagt     3840

ctccgggctg aagacacggc cacatacttc tgtacgcgga gagggtatga ctggtatttt     3900

gatgtgtggg gtcagggaac aaccgtgact gtttcaagct acgtcaccgt ctcttcacag     3960

gatcccgccg agcccaaatc tcctgacaaa actcacacat gcccaccgtg cccagcacct     4020

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     4080

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     4140

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     4200

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     4260

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     4320

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     4380

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     4440

tatcccagcg acatcgccgt ggagtgggag agcaatgggc aaccggagaa caactacaag     4500

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     4560

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     4620

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaaaaaga tcccaaattt     4680

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     4740

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     4800

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     4860

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     4920

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     4980

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     5040

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     5100

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     5160

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     5220

ccgcagtgta ctaattatgc tctcttgaaa ttggctggag atgttgagag caatcccggg     5280

cccatgcgga tcagcaagcc ccacctgcgg agcatcagca tccagtgcta cctgtgcctg     5340

ctgctgaaca gccacttcct gaccgaggcc ggcatccacg tgttcatcct gggctgcttc     5400

agcgccggac tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     5460

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     5520

caccccagct gcaaggtgac cgccatgaag tgctttctgc tggaactgca ggtgatcagc     5580

ctggaaagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     5640

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaagagtg cgaggaactg     5700

gaagagaaga acatcaaaga gtttctgcag agcttcgtgc acatcgtgca gatgttcatc     5760

aacaccagct gacgcgtcat catcgatccg gattagtcca atttgttaaa gacaggatat     5820

cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct atagagtacg     5880

agccatagat aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc     5940

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata     6000

cataactgag aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg     6060

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg     6120

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     6180

ggccaagaac agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc     6240

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     6300

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     6360

cacaacccct cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt     6420

atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt     6480

ctcctctgag tgattgacta cccgtcagcg ggggtctttc acacatgcag catgtatcaa     6540

aattaatttg gttttttttc ttaagtattt acattaaatg gccatagtac ttaaagttac     6600

attggcttcc ttgaaataaa catggagtat tcagaatgtg tcataaatat ttctaatttt     6660

aagatagtat ctccattggc tttctacttt ttcttttatt tttttttgtc ctctgtcttc     6720

catttgttgt tgttgttgtt tgtttgtttg tttgttggtt ggttggttaa ttttttttta     6780

aagatcctac actatagttc aagctagact attagctact ctgtaaccca gggtgacctt     6840

gaagtcatgg gtagcctgct gttttagcct tcccacatct aagattacag gtatgagcta     6900

tcatttttgg tatattgatt gattgattga ttgatgtgtg tgtgtgtgat tgtgtttgtg     6960

tgtgtgactg tgaaaatgtg tgtatgggtg tgtgtgaatg tgtgtatgta tgtgtgtgtg     7020

tgagtgtgtg tgtgtgtgtg tgcatgtgtg tgtgtgtgac tgtgtctatg tgtatgactg     7080

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttgtga aaaaatattc     7140

tatggtagtg agagccaacg ctccggctca ggtgtcaggt tggtttttga gacagagtct     7200

ttcacttagc ttggaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     7260

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     7320

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcc     7380

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc     7440

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     7500

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     7560

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     7620

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     7680

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     7740

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     7800

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     7860

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     7920

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     7980

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     8040

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     8100

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     8160

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     8220

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     8280

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     8340

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     8400

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     8460

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     8520

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     8580

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     8640

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     8700

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     8760

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     8820

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     8880

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     8940

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag     9000

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     9060

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     9120

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     9180

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     9240

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     9300

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     9360

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     9420

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     9480

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg     9540

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga     9600

gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc     9660

attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa     9720

ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc     9780

gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg     9840

attacgccaa gctttgctct taggagtttc ctaatacatc ccaaactcaa atatataaag     9900

catttgactt gttctatgcc ctagggggcg gggggaagct aagccagctt tttttaacat     9960

ttaaaatgtt aattccattt taaatgcaca gatgttttta tttcataagg gtttcaatgt    10020

gcatgaatgc tgcaatattc ctgttaccaa agctagtata aataaaaata gataaacgtg    10080

gaaattactt agagtttctg tcattaacgt ttccttcctc agttgacaac ataaatgcgc    10140

tgctgagcaa gccagtttgc atctgtcagg atcaatttcc cattatgcca gtcatattaa    10200

ttactagtca attagttgat ttttattttt gacatataca tgtg                     10244


<210>  38
<211>  10625
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-CD19CAR-Ev3

<400>  38
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagtttgggc tgagctggct ttttcttgtg     3180

gctattttaa aaggtgtcca gtgctctaga gacatccaga tgacacagac tacatcctcc     3240

ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattagt     3300

aaatatttaa attggtatca gcagaaacca gatggaactg ttaaactcct gatctaccat     3360

acatcaagat tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat     3420

tattctctca ccattagcaa cctggagcaa gaagatattg ccacttactt ttgccaacag     3480

ggtaatacgc ttccgtacac gttcggaggg gggaccaagc tggagctgaa acgtggtggt     3540

ggtggttctg gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg atccgaggtg     3600

cagctgcagc agtctggacc tggcctggtg gcgccctcac agagcctgtc cgtcacatgc     3660

actgtctcag gggtctcatt acccgactat ggtgtaagct ggattcgcca gcctccacga     3720

aagggtctgg agtggctggg agtaatatgg ggtagtgaaa ccacatacta taattcagct     3780

ctcaaatcca gactgaccat catcaaggac aactccaaga gccaagtttt cttaaaaatg     3840

aacagtctgc aaactgatga cacagccatt tactactgtg ccaaacatta ttactacggt     3900

ggtagctatg ctatggacta ctggggccaa gggaccacgg tcaccgtctc ctcgtacgtc     3960

accgtctctt cacaggatcc cgccctggaa gagaagaaag gcaattacgt cgtgaccgac     4020

cacggcagct gtgtgcgggc ttgtggcgcc gatagctacg agatggaaga ggacggcgtg     4080

cggaagtgca agaagtgcga gggcccctgc agaaaagtgt gcaacggcat cggcatcgga     4140

gagttcaagg atagcctgag catcaacgcc accaacatca agcacttcaa gaactgcacc     4200

agcatcagcg gcgacctgca catcctgccc gtggccttta gaggcgacag cttcacccac     4260

acccccccac tggatcccca ggaactggac atcctgaaaa ccgtgaaaga gatcacaggc     4320

tttctgctga ttcaggcctg gcccgagaac cggacagacc tgcacgcctt cgagaacctg     4380

gaaatcatca gaggccggac caagcagcac ggccagtttt ctctggccgt ggtgtccctg     4440

aacatcacca gcctgggcct gcggagcctg aaagaaatca gcgacggcga cgtgatcatc     4500

tccggcaaca agaacctgtg ctacgccaac accatcaatt ggaagaagct gttcggcacc     4560

tccggccaga aaacaaagat catctctaac cggggcgaga acagctgcaa agccaccgga     4620

caagtgtgcc acgccctgtg tagccctgag ggctgttggg gacccgagcc cagagattgc     4680

gtgtcctgcc ggaatgtgtc cagaggccgc gagtgcgtgg acaagtgcaa cctgctggaa     4740

ggcgagcccc gcgagtttgt ggaaaacagc gagtgcatcc agtgccaccc cgagtgtctg     4800

ccccaggcca tgaacattac ctgcaccggc agaggccccg acaactgtat ccagtgcgcc     4860

cactacatcg acggccccca ctgcgtgaaa acctgtccag ctggcgtgat gggagagaac     4920

aacaccctcg tgtggaagta cgccgacgcc ggccatgtgt gccacctgtg tcaccccaat     4980

tgcacctacg gctgtaccgg ccctggcctg gaaggctgtc ctaccaacgg ccccaagatc     5040

ccttctaaag atcccaaatt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat     5100

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc     5160

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     5220

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     5280

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     5340

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     5400

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     5460

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     5520

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     5580

caggccctgc cccctcgcgg accgcagtgt actaattatg ctctcttgaa attggctgga     5640

gatgttgaga gcaatcccgg gcccatgcgg atcagcaagc cccacctgcg gagcatcagc     5700

atccagtgct acctgtgcct gctgctgaac agccacttcc tgaccgaggc cggcatccac     5760

gtgttcatcc tgggctgctt cagcgccgga ctgcccaaga ccgaggccaa ctgggtgaac     5820

gtgatcagcg acctgaagaa gatcgaggac ctgatccaga gcatgcacat cgacgccacc     5880

ctgtacaccg agagcgacgt gcaccccagc tgcaaggtga ccgccatgaa gtgctttctg     5940

ctggaactgc aggtgatcag cctggaaagc ggcgacgcca gcatccacga caccgtggag     6000

aacctgatca tcctggccaa caacagcctg agcagcaacg gcaacgtgac cgagagcggc     6060

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gagcttcgtg     6120

cacatcgtgc agatgttcat caacaccagc tgacgcgtca tcatcgatcc ggattagtcc     6180

aatttgttaa agacaggata tcagtggtcc aggctctagt tttgactcaa caatatcacc     6240

agctgaagcc tatagagtac gagccataga taaaataaaa gattttattt agtctccaga     6300

aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat     6360

tttgcaaggc atggaaaaat acataactga gaatagagaa gttcagatca aggtcaggaa     6420

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     6480

gctcagggcc aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa     6540

gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc     6600

agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct     6660

gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttctgctc     6720

cccgagctca ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact     6780

gagtcgcccg ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt     6840

ctcgctgttc cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt     6900

cacacatgca gcatgtatca aaattaattt ggtttttttt cttaagtatt tacattaaat     6960

ggccatagta cttaaagtta cattggcttc cttgaaataa acatggagta ttcagaatgt     7020

gtcataaata tttctaattt taagatagta tctccattgg ctttctactt tttcttttat     7080

ttttttttgt cctctgtctt ccatttgttg ttgttgttgt ttgtttgttt gtttgttggt     7140

tggttggtta attttttttt aaagatccta cactatagtt caagctagac tattagctac     7200

tctgtaaccc agggtgacct tgaagtcatg ggtagcctgc tgttttagcc ttcccacatc     7260

taagattaca ggtatgagct atcatttttg gtatattgat tgattgattg attgatgtgt     7320

gtgtgtgtga ttgtgtttgt gtgtgtgact gtgaaaatgt gtgtatgggt gtgtgtgaat     7380

gtgtgtatgt atgtgtgtgt gtgagtgtgt gtgtgtgtgt gtgcatgtgt gtgtgtgtga     7440

ctgtgtctat gtgtatgact gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     7500

gtgtgttgtg aaaaaatatt ctatggtagt gagagccaac gctccggctc aggtgtcagg     7560

ttggtttttg agacagagtc tttcacttag cttggaattc actggccgtc gttttacaac     7620

gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt     7680

tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca     7740

gcctgaatgg cgaatggcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt     7800

cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc     7860

cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg     7920

cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat     7980

caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca     8040

tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc     8100

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     8160

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     8220

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     8280

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     8340

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     8400

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     8460

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     8520

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     8580

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     8640

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     8700

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     8760

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga     8820

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     8880

ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc     8940

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     9000

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt     9060

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     9120

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     9180

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     9240

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     9300

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     9360

taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     9420

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     9480

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     9540

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     9600

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     9660

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     9720

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     9780

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     9840

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     9900

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     9960

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc    10020

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag    10080

cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt    10140

tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca    10200

caggaaacag ctatgaccat gattacgcca agctttgctc ttaggagttt cctaatacat    10260

cccaaactca aatatataaa gcatttgact tgttctatgc cctagggggc ggggggaagc    10320

taagccagct ttttttaaca tttaaaatgt taattccatt ttaaatgcac agatgttttt    10380

atttcataag ggtttcaatg tgcatgaatg ctgcaatatt cctgttacca aagctagtat    10440

aaataaaaat agataaacgt ggaaattact tagagtttct gtcattaacg tttccttcct    10500

cagttgacaa cataaatgcg ctgctgagca agccagtttg catctgtcag gatcaatttc    10560

ccattatgcc agtcatatta attactagtc aattagttga tttttatttt tgacatatac    10620

atgtg                                                                10625


<210>  39
<211>  10619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-hCD19-Ev3-CAR

<400>  39
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggtt tgagctggct ctttcttgtt     3180

gctatcctca agggggtgca gtgttcaagg gatatccaga tgactcagag ccctagctcc     3240

cttagcgcgt ccgtcggcga ccgggttaca attacttgtc gcgcatcaca agacataagt     3300

aaatacttga actggtatca acaaaagcca ggaaaggttc caaaactcct catctatcac     3360

acgagtagac tccattccgg ggtccctgat cggttctcag gctctggttc tggaactgac     3420

ttcactctca cgatctctag tctgcaacct gaggatgtcg ctacctatta ttgccaacag     3480

ggaaacaccc tcccttacac atttggccaa ggtaccaaag ttgagatcaa gaggggctcc     3540

acatctggga gcgggaaacc gggaagtgga gaaggctcaa ccaaaggtga ggtgcaactt     3600

gtagagagtg gtggaggcct ggttcagccg ggagggtccc tcagacttag ttgcgcggct     3660

tctggcgttt cactgccgga ctacggggtc agttgggtta ggcaggcgcc tgggaaagga     3720

cttgagtgga tcggcgtgat atggggtagt gaaacaacct actacaatag tgctcttaaa     3780

tcaaaattca ttatcagccg agacaatgct aagaactccc tctatctcca aatgaatagt     3840

cttagagcag aagacacagc cgtttattac tgtgcccgcc attattacta tgggggcagc     3900

tacgcaatgg attattgggg ccaagggacc ctggtcacgg tatcaagcta cgtcaccgtc     3960

tcttcacagg atcccgccct ggaagagaag aaaggcaatt acgtcgtgac cgaccacggc     4020

agctgtgtgc gggcttgtgg cgccgatagc tacgagatgg aagaggacgg cgtgcggaag     4080

tgcaagaagt gcgagggccc ctgcagaaaa gtgtgcaacg gcatcggcat cggagagttc     4140

aaggatagcc tgagcatcaa cgccaccaac atcaagcact tcaagaactg caccagcatc     4200

agcggcgacc tgcacatcct gcccgtggcc tttagaggcg acagcttcac ccacaccccc     4260

ccactggatc cccaggaact ggacatcctg aaaaccgtga aagagatcac aggctttctg     4320

ctgattcagg cctggcccga gaaccggaca gacctgcacg ccttcgagaa cctggaaatc     4380

atcagaggcc ggaccaagca gcacggccag ttttctctgg ccgtggtgtc cctgaacatc     4440

accagcctgg gcctgcggag cctgaaagaa atcagcgacg gcgacgtgat catctccggc     4500

aacaagaacc tgtgctacgc caacaccatc aattggaaga agctgttcgg cacctccggc     4560

cagaaaacaa agatcatctc taaccggggc gagaacagct gcaaagccac cggacaagtg     4620

tgccacgccc tgtgtagccc tgagggctgt tggggacccg agcccagaga ttgcgtgtcc     4680

tgccggaatg tgtccagagg ccgcgagtgc gtggacaagt gcaacctgct ggaaggcgag     4740

ccccgcgagt ttgtggaaaa cagcgagtgc atccagtgcc accccgagtg tctgccccag     4800

gccatgaaca ttacctgcac cggcagaggc cccgacaact gtatccagtg cgcccactac     4860

atcgacggcc cccactgcgt gaaaacctgt ccagctggcg tgatgggaga gaacaacacc     4920

ctcgtgtgga agtacgccga cgccggccat gtgtgccacc tgtgtcaccc caattgcacc     4980

tacggctgta ccggccctgg cctggaaggc tgtcctacca acggccccaa gatcccttct     5040

aaagatccca aattttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg     5100

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac     5160

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     5220

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     5280

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     5340

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     5400

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     5460

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     5520

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     5580

ctgccccctc gcggaccgca gtgtactaat tatgctctct tgaaattggc tggagatgtt     5640

gagagcaatc ccgggcccat gcggatcagc aagccccacc tgcggagcat cagcatccag     5700

tgctacctgt gcctgctgct gaacagccac ttcctgaccg aggccggcat ccacgtgttc     5760

atcctgggct gcttcagcgc cggactgccc aagaccgagg ccaactgggt gaacgtgatc     5820

agcgacctga agaagatcga ggacctgatc cagagcatgc acatcgacgc caccctgtac     5880

accgagagcg acgtgcaccc cagctgcaag gtgaccgcca tgaagtgctt tctgctggaa     5940

ctgcaggtga tcagcctgga aagcggcgac gccagcatcc acgacaccgt ggagaacctg     6000

atcatcctgg ccaacaacag cctgagcagc aacggcaacg tgaccgagag cggctgcaaa     6060

gagtgcgagg aactggaaga gaagaacatc aaagagtttc tgcagagctt cgtgcacatc     6120

gtgcagatgt tcatcaacac cagctgacgc gtcatcatcg atccggatta gtccaatttg     6180

ttaaagacag gatatcagtg gtccaggctc tagttttgac tcaacaatat caccagctga     6240

agcctataga gtacgagcca tagataaaat aaaagatttt atttagtctc cagaaaaagg     6300

ggggaatgaa agaccccacc tgtaggtttg gcaagctagc ttaagtaacg ccattttgca     6360

aggcatggaa aaatacataa ctgagaatag agaagttcag atcaaggtca ggaacagatg     6420

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     6480

ggccaagaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt     6540

cctgccccgg ctcagggcca agaacagatg gtccccagat gcggtccagc cctcagcagt     6600

ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga ccctgtgcct     6660

tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct gctccccgag     6720

ctcaataaaa gagcccacaa cccctcactc ggggcgccag tcctccgatt gactgagtcg     6780

cccgggtacc cgtgtatcca ataaaccctc ttgcagttgc atccgacttg tggtctcgct     6840

gttccttggg agggtctcct ctgagtgatt gactacccgt cagcgggggt ctttcacaca     6900

tgcagcatgt atcaaaatta atttggtttt ttttcttaag tatttacatt aaatggccat     6960

agtacttaaa gttacattgg cttccttgaa ataaacatgg agtattcaga atgtgtcata     7020

aatatttcta attttaagat agtatctcca ttggctttct actttttctt ttattttttt     7080

ttgtcctctg tcttccattt gttgttgttg ttgtttgttt gtttgtttgt tggttggttg     7140

gttaattttt ttttaaagat cctacactat agttcaagct agactattag ctactctgta     7200

acccagggtg accttgaagt catgggtagc ctgctgtttt agccttccca catctaagat     7260

tacaggtatg agctatcatt tttggtatat tgattgattg attgattgat gtgtgtgtgt     7320

gtgattgtgt ttgtgtgtgt gactgtgaaa atgtgtgtat gggtgtgtgt gaatgtgtgt     7380

atgtatgtgt gtgtgtgagt gtgtgtgtgt gtgtgtgcat gtgtgtgtgt gtgactgtgt     7440

ctatgtgtat gactgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     7500

tgtgaaaaaa tattctatgg tagtgagagc caacgctccg gctcaggtgt caggttggtt     7560

tttgagacag agtctttcac ttagcttgga attcactggc cgtcgtttta caacgtcgtg     7620

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     7680

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     7740

atggcgaatg gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     7800

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac     7860

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca     7920

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga     7980

aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa     8040

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt     8100

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa     8160

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta     8220

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag     8280

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca     8340

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     8400

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     8460

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     8520

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     8580

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     8640

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     8700

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     8760

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     8820

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     8880

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     8940

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     9000

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     9060

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     9120

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     9180

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     9240

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     9300

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     9360

atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     9420

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     9480

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     9540

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     9600

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     9660

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     9720

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     9780

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     9840

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     9900

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     9960

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg    10020

cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca    10080

gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact    10140

ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa    10200

acagctatga ccatgattac gccaagcttt gctcttagga gtttcctaat acatcccaaa    10260

ctcaaatata taaagcattt gacttgttct atgccctagg gggcgggggg aagctaagcc    10320

agcttttttt aacatttaaa atgttaattc cattttaaat gcacagatgt ttttatttca    10380

taagggtttc aatgtgcatg aatgctgcaa tattcctgtt accaaagcta gtataaataa    10440

aaatagataa acgtggaaat tacttagagt ttctgtcatt aacgtttcct tcctcagttg    10500

acaacataaa tgcgctgctg agcaagccag tttgcatctg tcaggatcaa tttcccatta    10560

tgccagtcat attaattact agtcaattag ttgattttta tttttgacat atacatgtg     10619


<210>  40
<211>  10604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-CD123-Ev3-CAR

<400>  40
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagtttggac tgtcatggct ttttctggtt     3180

gctatattga aaggtgtcca atgcagtaga gacgtacaaa taactcaatc ccctagttac     3240

ttggctgcgt caccaggaga gaccataaca attaactgta gagcgagcaa atctattagc     3300

aaggaccttg catggtacca ggaaaagccc ggaaaaacga ataaacttct tatatactct     3360

ggctcaactt tgcaaagtgg aattccgtca agatttagtg gtagcgggtc tggaaccgac     3420

ttcacattga ctataagttc cttggagccg gaggattttg cgatgtatta ttgccagcaa     3480

cataataaat atccctatac tttcggggga ggaactaaat tggagataaa gggttcaact     3540

tctgggtctg gtaaacctgg cagcggcgaa ggtagcacaa aagggcaagt ccaactccag     3600

cagcccggcg cggaactcgt gcgacctggc gcttcagtta agctgagctg caaggcctca     3660

ggatacacct tcacaagcta ctggatgaat tgggtgaagc agaggcctga tcaaggactc     3720

gaatggatag gtagaattga tccctacgac tccgagacgc attataacca gaaatttaag     3780

gataaggcga ttcttaccgt ggacaaaagt tcttcaacgg catatatgca actgagcagt     3840

ttgacatcag aagacagtgc tgtttattac tgcgcgagag gtaactggga tgactactgg     3900

ggccagggca ctaccttggt taccgtgtca agctacgtca ccgtctcttc acaggatccc     3960

gccctggaag agaagaaagg caattacgtc gtgaccgacc acggcagctg tgtgcgggct     4020

tgtggcgccg atagctacga gatggaagag gacggcgtgc ggaagtgcaa gaagtgcgag     4080

ggcccctgca gaaaagtgtg caacggcatc ggcatcggag agttcaagga tagcctgagc     4140

atcaacgcca ccaacatcaa gcacttcaag aactgcacca gcatcagcgg cgacctgcac     4200

atcctgcccg tggcctttag aggcgacagc ttcacccaca cccccccact ggatccccag     4260

gaactggaca tcctgaaaac cgtgaaagag atcacaggct ttctgctgat tcaggcctgg     4320

cccgagaacc ggacagacct gcacgccttc gagaacctgg aaatcatcag aggccggacc     4380

aagcagcacg gccagttttc tctggccgtg gtgtccctga acatcaccag cctgggcctg     4440

cggagcctga aagaaatcag cgacggcgac gtgatcatct ccggcaacaa gaacctgtgc     4500

tacgccaaca ccatcaattg gaagaagctg ttcggcacct ccggccagaa aacaaagatc     4560

atctctaacc ggggcgagaa cagctgcaaa gccaccggac aagtgtgcca cgccctgtgt     4620

agccctgagg gctgttgggg acccgagccc agagattgcg tgtcctgccg gaatgtgtcc     4680

agaggccgcg agtgcgtgga caagtgcaac ctgctggaag gcgagccccg cgagtttgtg     4740

gaaaacagcg agtgcatcca gtgccacccc gagtgtctgc cccaggccat gaacattacc     4800

tgcaccggca gaggccccga caactgtatc cagtgcgccc actacatcga cggcccccac     4860

tgcgtgaaaa cctgtccagc tggcgtgatg ggagagaaca acaccctcgt gtggaagtac     4920

gccgacgccg gccatgtgtg ccacctgtgt caccccaatt gcacctacgg ctgtaccggc     4980

cctggcctgg aaggctgtcc taccaacggc cccaagatcc cttctaaaga tcccaaattt     5040

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     5100

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     5160

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     5220

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     5280

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     5340

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     5400

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     5460

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     5520

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     5580

ccgcagtgta ctaattatgc tctcttgaaa ttggctggag atgttgagag caatcccggg     5640

cccatgcgga tcagcaagcc ccacctgcgg agcatcagca tccagtgcta cctgtgcctg     5700

ctgctgaaca gccacttcct gaccgaggcc ggcatccacg tgttcatcct gggctgcttc     5760

agcgccggac tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     5820

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     5880

caccccagct gcaaggtgac cgccatgaag tgctttctgc tggaactgca ggtgatcagc     5940

ctggaaagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     6000

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaagagtg cgaggaactg     6060

gaagagaaga acatcaaaga gtttctgcag agcttcgtgc acatcgtgca gatgttcatc     6120

aacaccagct gacgcgtcat catcgatccg gattagtcca atttgttaaa gacaggatat     6180

cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct atagagtacg     6240

agccatagat aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc     6300

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata     6360

cataactgag aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg     6420

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg     6480

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     6540

ggccaagaac agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc     6600

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     6660

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     6720

cacaacccct cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt     6780

atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt     6840

ctcctctgag tgattgacta cccgtcagcg ggggtctttc acacatgcag catgtatcaa     6900

aattaatttg gttttttttc ttaagtattt acattaaatg gccatagtac ttaaagttac     6960

attggcttcc ttgaaataaa catggagtat tcagaatgtg tcataaatat ttctaatttt     7020

aagatagtat ctccattggc tttctacttt ttcttttatt tttttttgtc ctctgtcttc     7080

catttgttgt tgttgttgtt tgtttgtttg tttgttggtt ggttggttaa ttttttttta     7140

aagatcctac actatagttc aagctagact attagctact ctgtaaccca gggtgacctt     7200

gaagtcatgg gtagcctgct gttttagcct tcccacatct aagattacag gtatgagcta     7260

tcatttttgg tatattgatt gattgattga ttgatgtgtg tgtgtgtgat tgtgtttgtg     7320

tgtgtgactg tgaaaatgtg tgtatgggtg tgtgtgaatg tgtgtatgta tgtgtgtgtg     7380

tgagtgtgtg tgtgtgtgtg tgcatgtgtg tgtgtgtgac tgtgtctatg tgtatgactg     7440

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttgtga aaaaatattc     7500

tatggtagtg agagccaacg ctccggctca ggtgtcaggt tggtttttga gacagagtct     7560

ttcacttagc ttggaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     7620

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     7680

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcc     7740

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc     7800

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     7860

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     7920

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     7980

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     8040

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     8100

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     8160

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     8220

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     8280

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     8340

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     8400

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     8460

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     8520

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     8580

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     8640

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     8700

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     8760

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     8820

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     8880

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     8940

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     9000

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     9060

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     9120

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     9180

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     9240

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     9300

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag     9360

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     9420

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     9480

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     9540

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     9600

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     9660

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     9720

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     9780

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     9840

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg     9900

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga     9960

gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc    10020

attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa    10080

ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc    10140

gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg    10200

attacgccaa gctttgctct taggagtttc ctaatacatc ccaaactcaa atatataaag    10260

catttgactt gttctatgcc ctagggggcg gggggaagct aagccagctt tttttaacat    10320

ttaaaatgtt aattccattt taaatgcaca gatgttttta tttcataagg gtttcaatgt    10380

gcatgaatgc tgcaatattc ctgttaccaa agctagtata aataaaaata gataaacgtg    10440

gaaattactt agagtttctg tcattaacgt ttccttcctc agttgacaac ataaatgcgc    10500

tgctgagcaa gccagtttgc atctgtcagg atcaatttcc cattatgcca gtcatattaa    10560

ttactagtca attagttgat ttttattttt gacatataca tgtg                     10604


<210>  41
<211>  10604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-hCD123-Ev3-CAR

<400>  41
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gaattcgggc tttcatggtt gttcctcgtt     3180

gcgatactta aaggcgttca gtgcagtaga gacattcaga tgacccaaag ccctagtagc     3240

ctctccgcca gtgtgggtga ccgcgtgact attacgtgcc gagcaagcaa gagtattagc     3300

aaagatttgg catggtacca gcagaaacca ggcaaggtcc ctaagttgct tatatatagc     3360

gggtctacac tccaatctgg agtgccggat cgcttctcag gttccggatc aggaaccgat     3420

ttcactctta caatttcctc tctgcaaccg gaggacgtgg caacatacta ttgccagcag     3480

cataacaaat atccctatac tttcggtcaa ggtacaaaag tagaaataaa acgaggttcc     3540

acctccggga gtgggaagcc cggctccggc gaaggatcca ccaaaggcga ggtacagctc     3600

gttgaaagcg ggggcggtct cgtccaacca ggagggtctc ttcgactttc ttgtgctgca     3660

agtgggtaca cgtttacttc ctattggatg aattgggttc ggcaagcccc cggtaaaggg     3720

cttgaatgga tagggaggat agacccctac gattctgaga cgcattataa tcagaaattc     3780

aaagataagt tcataataag cagagacaat gcaaaaaata gtttgtacct ccagatgaat     3840

agtcttcggg cagaagacac agcggtatat tactgtgctc ggggtaactg ggatgattac     3900

tggggtcagg gaactctggt tactgtgtct agctacgtca ccgtctcttc acaggatccc     3960

gccctggaag agaagaaagg caattacgtc gtgaccgacc acggcagctg tgtgcgggct     4020

tgtggcgccg atagctacga gatggaagag gacggcgtgc ggaagtgcaa gaagtgcgag     4080

ggcccctgca gaaaagtgtg caacggcatc ggcatcggag agttcaagga tagcctgagc     4140

atcaacgcca ccaacatcaa gcacttcaag aactgcacca gcatcagcgg cgacctgcac     4200

atcctgcccg tggcctttag aggcgacagc ttcacccaca cccccccact ggatccccag     4260

gaactggaca tcctgaaaac cgtgaaagag atcacaggct ttctgctgat tcaggcctgg     4320

cccgagaacc ggacagacct gcacgccttc gagaacctgg aaatcatcag aggccggacc     4380

aagcagcacg gccagttttc tctggccgtg gtgtccctga acatcaccag cctgggcctg     4440

cggagcctga aagaaatcag cgacggcgac gtgatcatct ccggcaacaa gaacctgtgc     4500

tacgccaaca ccatcaattg gaagaagctg ttcggcacct ccggccagaa aacaaagatc     4560

atctctaacc ggggcgagaa cagctgcaaa gccaccggac aagtgtgcca cgccctgtgt     4620

agccctgagg gctgttgggg acccgagccc agagattgcg tgtcctgccg gaatgtgtcc     4680

agaggccgcg agtgcgtgga caagtgcaac ctgctggaag gcgagccccg cgagtttgtg     4740

gaaaacagcg agtgcatcca gtgccacccc gagtgtctgc cccaggccat gaacattacc     4800

tgcaccggca gaggccccga caactgtatc cagtgcgccc actacatcga cggcccccac     4860

tgcgtgaaaa cctgtccagc tggcgtgatg ggagagaaca acaccctcgt gtggaagtac     4920

gccgacgccg gccatgtgtg ccacctgtgt caccccaatt gcacctacgg ctgtaccggc     4980

cctggcctgg aaggctgtcc taccaacggc cccaagatcc cttctaaaga tcccaaattt     5040

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     5100

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     5160

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     5220

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     5280

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     5340

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     5400

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     5460

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     5520

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     5580

ccgcagtgta ctaattatgc tctcttgaaa ttggctggag atgttgagag caatcccggg     5640

cccatgcgga tcagcaagcc ccacctgcgg agcatcagca tccagtgcta cctgtgcctg     5700

ctgctgaaca gccacttcct gaccgaggcc ggcatccacg tgttcatcct gggctgcttc     5760

agcgccggac tgcccaagac cgaggccaac tgggtgaacg tgatcagcga cctgaagaag     5820

atcgaggacc tgatccagag catgcacatc gacgccaccc tgtacaccga gagcgacgtg     5880

caccccagct gcaaggtgac cgccatgaag tgctttctgc tggaactgca ggtgatcagc     5940

ctggaaagcg gcgacgccag catccacgac accgtggaga acctgatcat cctggccaac     6000

aacagcctga gcagcaacgg caacgtgacc gagagcggct gcaaagagtg cgaggaactg     6060

gaagagaaga acatcaaaga gtttctgcag agcttcgtgc acatcgtgca gatgttcatc     6120

aacaccagct gacgcgtcat catcgatccg gattagtcca atttgttaaa gacaggatat     6180

cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct atagagtacg     6240

agccatagat aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc     6300

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata     6360

cataactgag aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg     6420

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg     6480

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     6540

ggccaagaac agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc     6600

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     6660

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     6720

cacaacccct cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt     6780

atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt     6840

ctcctctgag tgattgacta cccgtcagcg ggggtctttc acacatgcag catgtatcaa     6900

aattaatttg gttttttttc ttaagtattt acattaaatg gccatagtac ttaaagttac     6960

attggcttcc ttgaaataaa catggagtat tcagaatgtg tcataaatat ttctaatttt     7020

aagatagtat ctccattggc tttctacttt ttcttttatt tttttttgtc ctctgtcttc     7080

catttgttgt tgttgttgtt tgtttgtttg tttgttggtt ggttggttaa ttttttttta     7140

aagatcctac actatagttc aagctagact attagctact ctgtaaccca gggtgacctt     7200

gaagtcatgg gtagcctgct gttttagcct tcccacatct aagattacag gtatgagcta     7260

tcatttttgg tatattgatt gattgattga ttgatgtgtg tgtgtgtgat tgtgtttgtg     7320

tgtgtgactg tgaaaatgtg tgtatgggtg tgtgtgaatg tgtgtatgta tgtgtgtgtg     7380

tgagtgtgtg tgtgtgtgtg tgcatgtgtg tgtgtgtgac tgtgtctatg tgtatgactg     7440

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttgtga aaaaatattc     7500

tatggtagtg agagccaacg ctccggctca ggtgtcaggt tggtttttga gacagagtct     7560

ttcacttagc ttggaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     7620

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     7680

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcc     7740

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc     7800

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     7860

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     7920

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     7980

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     8040

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     8100

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     8160

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     8220

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     8280

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     8340

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     8400

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     8460

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     8520

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     8580

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     8640

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     8700

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     8760

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     8820

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     8880

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     8940

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     9000

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     9060

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     9120

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     9180

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     9240

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     9300

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag     9360

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     9420

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     9480

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     9540

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     9600

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     9660

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     9720

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     9780

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     9840

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg     9900

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga     9960

gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc    10020

attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa    10080

ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc    10140

gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg    10200

attacgccaa gctttgctct taggagtttc ctaatacatc ccaaactcaa atatataaag    10260

catttgactt gttctatgcc ctagggggcg gggggaagct aagccagctt tttttaacat    10320

ttaaaatgtt aattccattt taaatgcaca gatgttttta tttcataagg gtttcaatgt    10380

gcatgaatgc tgcaatattc ctgttaccaa agctagtata aataaaaata gataaacgtg    10440

gaaattactt agagtttctg tcattaacgt ttccttcctc agttgacaac ataaatgcgc    10500

tgctgagcaa gccagtttgc atctgtcagg atcaatttcc cattatgcca gtcatattaa    10560

ttactagtca attagttgat ttttattttt gacatataca tgtg                     10604


<210>  42
<211>  10610
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-Meso-Ev3-CAR

<400>  42
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggcc ttagctggct gttccttgtg     3180

gccatactca agggcgtcca gtgtagtcgc gatatagagc tgacgcaaag cccggcaatt     3240

atgtcagcaa gtccaggaga aaaggtgact atgacttgtt ccgcaagcag ttctgtaagt     3300

tacatgcact ggtaccagca aaaaagtgga actagcccta agcggtggat ctatgacacg     3360

tctaaattgg cctctggtgt ccccggacga ttttcaggtt caggaagtgg aaacagttac     3420

tctcttacta taagtagcgt cgaggcggag gatgacgcca cctactactg ccagcagtgg     3480

agcgggtacc ccctcacctt cggggccggg accaagttgg agattaaagg atcaacatcc     3540

gggagcggaa agccggggtc aggtgagggc tcaacaaaag ggcaggtaca gctccagcaa     3600

agtgggcccg agctggaaaa accgggtgcg agtgtcaaac tttcttgtaa ggccagcggt     3660

tactctttca cgggttatac aatgaattgg gtgaaacagt cccacggcaa gagcctcgaa     3720

tggataggtc tcatcacacc atacaacgga gcttcctcct ataatcagaa gttccgggga     3780

aaggcaaccc tcactgtaga caagtcttcc tcaacagcat atatggatct cctgtcactc     3840

acgtccgaag acagcgcggt ttatttttgt gcgagagggg gttatgacgg gcgcgggttc     3900

gactactggg gtcaaggcac tacagtaacg gtaagcagct acgtcaccgt ctcttcacag     3960

gatcccgccc tggaagagaa gaaaggcaat tacgtcgtga ccgaccacgg cagctgtgtg     4020

cgggcttgtg gcgccgatag ctacgagatg gaagaggacg gcgtgcggaa gtgcaagaag     4080

tgcgagggcc cctgcagaaa agtgtgcaac ggcatcggca tcggagagtt caaggatagc     4140

ctgagcatca acgccaccaa catcaagcac ttcaagaact gcaccagcat cagcggcgac     4200

ctgcacatcc tgcccgtggc ctttagaggc gacagcttca cccacacccc cccactggat     4260

ccccaggaac tggacatcct gaaaaccgtg aaagagatca caggctttct gctgattcag     4320

gcctggcccg agaaccggac agacctgcac gccttcgaga acctggaaat catcagaggc     4380

cggaccaagc agcacggcca gttttctctg gccgtggtgt ccctgaacat caccagcctg     4440

ggcctgcgga gcctgaaaga aatcagcgac ggcgacgtga tcatctccgg caacaagaac     4500

ctgtgctacg ccaacaccat caattggaag aagctgttcg gcacctccgg ccagaaaaca     4560

aagatcatct ctaaccgggg cgagaacagc tgcaaagcca ccggacaagt gtgccacgcc     4620

ctgtgtagcc ctgagggctg ttggggaccc gagcccagag attgcgtgtc ctgccggaat     4680

gtgtccagag gccgcgagtg cgtggacaag tgcaacctgc tggaaggcga gccccgcgag     4740

tttgtggaaa acagcgagtg catccagtgc caccccgagt gtctgcccca ggccatgaac     4800

attacctgca ccggcagagg ccccgacaac tgtatccagt gcgcccacta catcgacggc     4860

ccccactgcg tgaaaacctg tccagctggc gtgatgggag agaacaacac cctcgtgtgg     4920

aagtacgccg acgccggcca tgtgtgccac ctgtgtcacc ccaattgcac ctacggctgt     4980

accggccctg gcctggaagg ctgtcctacc aacggcccca agatcccttc taaagatccc     5040

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     5100

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     5160

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     5220

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     5280

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     5340

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     5400

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     5460

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     5520

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     5580

cgcggaccgc agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaat     5640

cccgggccca tgcggatcag caagccccac ctgcggagca tcagcatcca gtgctacctg     5700

tgcctgctgc tgaacagcca cttcctgacc gaggccggca tccacgtgtt catcctgggc     5760

tgcttcagcg ccggactgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg     5820

aagaagatcg aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc     5880

gacgtgcacc ccagctgcaa ggtgaccgcc atgaagtgct ttctgctgga actgcaggtg     5940

atcagcctgg aaagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg     6000

gccaacaaca gcctgagcag caacggcaac gtgaccgaga gcggctgcaa agagtgcgag     6060

gaactggaag agaagaacat caaagagttt ctgcagagct tcgtgcacat cgtgcagatg     6120

ttcatcaaca ccagctgacg cgtcatcatc gatccggatt agtccaattt gttaaagaca     6180

ggatatcagt ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag     6240

agtacgagcc atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga     6300

aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga     6360

aaaatacata actgagaata gagaagttca gatcaaggtc aggaacagat ggaacagctg     6420

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     6480

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     6540

gctcagggcc aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga     6600

accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac     6660

taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctcaataaa     6720

agagcccaca acccctcact cggggcgcca gtcctccgat tgactgagtc gcccgggtac     6780

ccgtgtatcc aataaaccct cttgcagttg catccgactt gtggtctcgc tgttccttgg     6840

gagggtctcc tctgagtgat tgactacccg tcagcggggg tctttcacac atgcagcatg     6900

tatcaaaatt aatttggttt tttttcttaa gtatttacat taaatggcca tagtacttaa     6960

agttacattg gcttccttga aataaacatg gagtattcag aatgtgtcat aaatatttct     7020

aattttaaga tagtatctcc attggctttc tactttttct tttatttttt tttgtcctct     7080

gtcttccatt tgttgttgtt gttgtttgtt tgtttgtttg ttggttggtt ggttaatttt     7140

tttttaaaga tcctacacta tagttcaagc tagactatta gctactctgt aacccagggt     7200

gaccttgaag tcatgggtag cctgctgttt tagccttccc acatctaaga ttacaggtat     7260

gagctatcat ttttggtata ttgattgatt gattgattga tgtgtgtgtg tgtgattgtg     7320

tttgtgtgtg tgactgtgaa aatgtgtgta tgggtgtgtg tgaatgtgtg tatgtatgtg     7380

tgtgtgtgag tgtgtgtgtg tgtgtgtgca tgtgtgtgtg tgtgactgtg tctatgtgta     7440

tgactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa     7500

atattctatg gtagtgagag ccaacgctcc ggctcaggtg tcaggttggt ttttgagaca     7560

gagtctttca cttagcttgg aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa     7620

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     7680

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     7740

ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     7800

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     7860

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     7920

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     7980

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     8040

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     8100

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     8160

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     8220

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     8280

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     8340

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     8400

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     8460

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     8520

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     8580

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     8640

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     8700

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     8760

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     8820

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     8880

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     8940

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     9000

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     9060

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     9120

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     9180

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     9240

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     9300

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     9360

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     9420

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     9480

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     9540

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     9600

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     9660

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     9720

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     9780

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     9840

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     9900

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     9960

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    10020

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    10080

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    10140

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    10200

accatgatta cgccaagctt tgctcttagg agtttcctaa tacatcccaa actcaaatat    10260

ataaagcatt tgacttgttc tatgccctag ggggcggggg gaagctaagc cagctttttt    10320

taacatttaa aatgttaatt ccattttaaa tgcacagatg tttttatttc ataagggttt    10380

caatgtgcat gaatgctgca atattcctgt taccaaagct agtataaata aaaatagata    10440

aacgtggaaa ttacttagag tttctgtcat taacgtttcc ttcctcagtt gacaacataa    10500

atgcgctgct gagcaagcca gtttgcatct gtcaggatca atttcccatt atgccagtca    10560

tattaattac tagtcaatta gttgattttt atttttgaca tatacatgtg               10610


<210>  43
<211>  10595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-hMeso-Ev3-CAR

<400>  43
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggcc tttcttggct gtttttggtc     3180

gcaatattga agggcgttca gtgttcaagg gacatacaga tgacgcagtc acctagctct     3240

ctttcagcct ctgtgggaga ccgcgttaca attacgtgtt ctgcttctag ttcagtgtct     3300

tacatgcatt ggtaccagca aaaacccggc aaggttccaa agctccttat atacgatacg     3360

tccaaactgg cttcaggcgt gccagacagg tttagtggat ctgggagcgg cactgacttc     3420

acacttacaa tatccagtct gcaacccgaa gatgttgcga catactattg tcagcaatgg     3480

agcggctatc cgctcaccgg acaggggaca aaagtggaga taaagcgggg ctccaccagt     3540

ggttccggga agcctggtag tggtgagggt tctacgaaag gcgaagtgca gttggtggag     3600

tctggtggcg ggcttgttca acccggtggt tctctcaggc ttagctgtgc agcctctggg     3660

tacacaatga attgggtaag gcaagcgcct ggaaagggcc ttgagtggat cggtttgata     3720

accccataca acggagcttc aagttacaac caaaagttcc gcgggaagtt tattataagc     3780

agggataacg caaagaacag cctctatctt caaatgaact cactccgggc tgaagacaca     3840

gccgtctatt attgtgcccg ggggggctac gacggacgag ggttcgatta ctggggtcag     3900

ggcacactcg tgaccgtgtc aagctacgtc accgtctctt cacaggatcc cgccctggaa     3960

gagaagaaag gcaattacgt cgtgaccgac cacggcagct gtgtgcgggc ttgtggcgcc     4020

gatagctacg agatggaaga ggacggcgtg cggaagtgca agaagtgcga gggcccctgc     4080

agaaaagtgt gcaacggcat cggcatcgga gagttcaagg atagcctgag catcaacgcc     4140

accaacatca agcacttcaa gaactgcacc agcatcagcg gcgacctgca catcctgccc     4200

gtggccttta gaggcgacag cttcacccac acccccccac tggatcccca ggaactggac     4260

atcctgaaaa ccgtgaaaga gatcacaggc tttctgctga ttcaggcctg gcccgagaac     4320

cggacagacc tgcacgcctt cgagaacctg gaaatcatca gaggccggac caagcagcac     4380

ggccagtttt ctctggccgt ggtgtccctg aacatcacca gcctgggcct gcggagcctg     4440

aaagaaatca gcgacggcga cgtgatcatc tccggcaaca agaacctgtg ctacgccaac     4500

accatcaatt ggaagaagct gttcggcacc tccggccaga aaacaaagat catctctaac     4560

cggggcgaga acagctgcaa agccaccgga caagtgtgcc acgccctgtg tagccctgag     4620

ggctgttggg gacccgagcc cagagattgc gtgtcctgcc ggaatgtgtc cagaggccgc     4680

gagtgcgtgg acaagtgcaa cctgctggaa ggcgagcccc gcgagtttgt ggaaaacagc     4740

gagtgcatcc agtgccaccc cgagtgtctg ccccaggcca tgaacattac ctgcaccggc     4800

agaggccccg acaactgtat ccagtgcgcc cactacatcg acggccccca ctgcgtgaaa     4860

acctgtccag ctggcgtgat gggagagaac aacaccctcg tgtggaagta cgccgacgcc     4920

ggccatgtgt gccacctgtg tcaccccaat tgcacctacg gctgtaccgg ccctggcctg     4980

gaaggctgtc ctaccaacgg ccccaagatc ccttctaaag atcccaaatt ttgggtgctg     5040

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     5100

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     5160

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     5220

gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     5280

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     5340

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     5400

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     5460

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     5520

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcgg accgcagtgt     5580

actaattatg ctctcttgaa attggctgga gatgttgaga gcaatcccgg gcccatgcgg     5640

atcagcaagc cccacctgcg gagcatcagc atccagtgct acctgtgcct gctgctgaac     5700

agccacttcc tgaccgaggc cggcatccac gtgttcatcc tgggctgctt cagcgccgga     5760

ctgcccaaga ccgaggccaa ctgggtgaac gtgatcagcg acctgaagaa gatcgaggac     5820

ctgatccaga gcatgcacat cgacgccacc ctgtacaccg agagcgacgt gcaccccagc     5880

tgcaaggtga ccgccatgaa gtgctttctg ctggaactgc aggtgatcag cctggaaagc     5940

ggcgacgcca gcatccacga caccgtggag aacctgatca tcctggccaa caacagcctg     6000

agcagcaacg gcaacgtgac cgagagcggc tgcaaagagt gcgaggaact ggaagagaag     6060

aacatcaaag agtttctgca gagcttcgtg cacatcgtgc agatgttcat caacaccagc     6120

tgacgcgtca tcatcgatcc ggattagtcc aatttgttaa agacaggata tcagtggtcc     6180

aggctctagt tttgactcaa caatatcacc agctgaagcc tatagagtac gagccataga     6240

taaaataaaa gattttattt agtctccaga aaaagggggg aatgaaagac cccacctgta     6300

ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc atggaaaaat acataactga     6360

gaatagagaa gttcagatca aggtcaggaa cagatggaac agctgaatat gggccaaaca     6420

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggaacagctg     6480

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     6540

cagatggtcc ccagatgcgg tccagccctc agcagtttct agagaaccat cagatgtttc     6600

cagggtgccc caaggacctg aaatgaccct gtgccttatt tgaactaacc aatcagttcg     6660

cttctcgctt ctgttcgcgc gcttctgctc cccgagctca ataaaagagc ccacaacccc     6720

tcactcgggg cgccagtcct ccgattgact gagtcgcccg ggtacccgtg tatccaataa     6780

accctcttgc agttgcatcc gacttgtggt ctcgctgttc cttgggaggg tctcctctga     6840

gtgattgact acccgtcagc gggggtcttt cacacatgca gcatgtatca aaattaattt     6900

ggtttttttt cttaagtatt tacattaaat ggccatagta cttaaagtta cattggcttc     6960

cttgaaataa acatggagta ttcagaatgt gtcataaata tttctaattt taagatagta     7020

tctccattgg ctttctactt tttcttttat ttttttttgt cctctgtctt ccatttgttg     7080

ttgttgttgt ttgtttgttt gtttgttggt tggttggtta attttttttt aaagatccta     7140

cactatagtt caagctagac tattagctac tctgtaaccc agggtgacct tgaagtcatg     7200

ggtagcctgc tgttttagcc ttcccacatc taagattaca ggtatgagct atcatttttg     7260

gtatattgat tgattgattg attgatgtgt gtgtgtgtga ttgtgtttgt gtgtgtgact     7320

gtgaaaatgt gtgtatgggt gtgtgtgaat gtgtgtatgt atgtgtgtgt gtgagtgtgt     7380

gtgtgtgtgt gtgcatgtgt gtgtgtgtga ctgtgtctat gtgtatgact gtgtgtgtgt     7440

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgttgtg aaaaaatatt ctatggtagt     7500

gagagccaac gctccggctc aggtgtcagg ttggtttttg agacagagtc tttcacttag     7560

cttggaattc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc     7620

aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc     7680

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcgc ctgatgcggt     7740

attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa     7800

tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc     7860

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     7920

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg     7980

tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg     8040

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     8100

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     8160

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     8220

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     8280

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     8340

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     8400

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     8460

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     8520

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     8580

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     8640

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     8700

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     8760

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     8820

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     8880

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     8940

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     9000

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     9060

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     9120

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     9180

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     9240

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     9300

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     9360

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     9420

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     9480

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     9540

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     9600

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     9660

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     9720

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     9780

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     9840

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     9900

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     9960

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca    10020

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga    10080

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt    10140

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca    10200

agctttgctc ttaggagttt cctaatacat cccaaactca aatatataaa gcatttgact    10260

tgttctatgc cctagggggc ggggggaagc taagccagct ttttttaaca tttaaaatgt    10320

taattccatt ttaaatgcac agatgttttt atttcataag ggtttcaatg tgcatgaatg    10380

ctgcaatatt cctgttacca aagctagtat aaataaaaat agataaacgt ggaaattact    10440

tagagtttct gtcattaacg tttccttcct cagttgacaa cataaatgcg ctgctgagca    10500

agccagtttg catctgtcag gatcaatttc ccattatgcc agtcatatta attactagtc    10560

aattagttga tttttatttt tgacatatac atgtg                               10595


<210>  44
<211>  10613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-ROR1-Ev3-CAR

<400>  44
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggtc ttagctggct gttcctcgtg     3180

gcaatcctca agggagtaca atgcagcaga gatattaaga tgacgcagtc cccctcttct     3240

atgtacgcga gtctgggaga gagggtaacc attacatgta aggcgtctcc cgatataaac     3300

tcatatctga gctggtttca acaaaagccg ggcaagagtc cgaagacact catttaccga     3360

gcaaaccgcc tggtagacgg tgtgccttcc agattctctg gcggtggcag cgggcaagac     3420

tactcactca ccataaattc acttgaatac gaggatatgg gtatatacta ctgcttgcaa     3480

tatgatgagt ttccatatac ttttggcggc ggaactaaac ttgaaatgaa agggagcacg     3540

tctggttccg gcaagcctgg ttcaggagag ggtagcacca aaggggaagt caaactcgtc     3600

gaaagtggtg gtggcttggt gaaacccggc ggatctctga aactcagttg tgccgcttct     3660

ggttttacat ttagctccta cgcgatgagt tgggtcaggc aaataccaga gaagagactt     3720

gagtgggtcg ctagtattag caggggaggg accacctact atccagactc tgtgaaaggt     3780

agattcacta tctctagaga caacgtacgc aatatcctgt atctccaaat gagctcattg     3840

aggagcgagg atacggctat gtactattgt ggccgatacg actatgatgg atactatgcg     3900

atggattact ggggccaagg cacttctgta acagtttcta gctacgtcac cgtctcttca     3960

caggatcccg ccctggaaga gaagaaaggc aattacgtcg tgaccgacca cggcagctgt     4020

gtgcgggctt gtggcgccga tagctacgag atggaagagg acggcgtgcg gaagtgcaag     4080

aagtgcgagg gcccctgcag aaaagtgtgc aacggcatcg gcatcggaga gttcaaggat     4140

agcctgagca tcaacgccac caacatcaag cacttcaaga actgcaccag catcagcggc     4200

gacctgcaca tcctgcccgt ggcctttaga ggcgacagct tcacccacac ccccccactg     4260

gatccccagg aactggacat cctgaaaacc gtgaaagaga tcacaggctt tctgctgatt     4320

caggcctggc ccgagaaccg gacagacctg cacgccttcg agaacctgga aatcatcaga     4380

ggccggacca agcagcacgg ccagttttct ctggccgtgg tgtccctgaa catcaccagc     4440

ctgggcctgc ggagcctgaa agaaatcagc gacggcgacg tgatcatctc cggcaacaag     4500

aacctgtgct acgccaacac catcaattgg aagaagctgt tcggcacctc cggccagaaa     4560

acaaagatca tctctaaccg gggcgagaac agctgcaaag ccaccggaca agtgtgccac     4620

gccctgtgta gccctgaggg ctgttgggga cccgagccca gagattgcgt gtcctgccgg     4680

aatgtgtcca gaggccgcga gtgcgtggac aagtgcaacc tgctggaagg cgagccccgc     4740

gagtttgtgg aaaacagcga gtgcatccag tgccaccccg agtgtctgcc ccaggccatg     4800

aacattacct gcaccggcag aggccccgac aactgtatcc agtgcgccca ctacatcgac     4860

ggcccccact gcgtgaaaac ctgtccagct ggcgtgatgg gagagaacaa caccctcgtg     4920

tggaagtacg ccgacgccgg ccatgtgtgc cacctgtgtc accccaattg cacctacggc     4980

tgtaccggcc ctggcctgga aggctgtcct accaacggcc ccaagatccc ttctaaagat     5040

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta     5100

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac     5160

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     5220

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     5280

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     5340

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     5400

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     5460

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     5520

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     5580

cctcgcggac cgcagtgtac taattatgct ctcttgaaat tggctggaga tgttgagagc     5640

aatcccgggc ccatgcggat cagcaagccc cacctgcgga gcatcagcat ccagtgctac     5700

ctgtgcctgc tgctgaacag ccacttcctg accgaggccg gcatccacgt gttcatcctg     5760

ggctgcttca gcgccggact gcccaagacc gaggccaact gggtgaacgt gatcagcgac     5820

ctgaagaaga tcgaggacct gatccagagc atgcacatcg acgccaccct gtacaccgag     5880

agcgacgtgc accccagctg caaggtgacc gccatgaagt gctttctgct ggaactgcag     5940

gtgatcagcc tggaaagcgg cgacgccagc atccacgaca ccgtggagaa cctgatcatc     6000

ctggccaaca acagcctgag cagcaacggc aacgtgaccg agagcggctg caaagagtgc     6060

gaggaactgg aagagaagaa catcaaagag tttctgcaga gcttcgtgca catcgtgcag     6120

atgttcatca acaccagctg acgcgtcatc atcgatccgg attagtccaa tttgttaaag     6180

acaggatatc agtggtccag gctctagttt tgactcaaca atatcaccag ctgaagccta     6240

tagagtacga gccatagata aaataaaaga ttttatttag tctccagaaa aaggggggaa     6300

tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat     6360

ggaaaaatac ataactgaga atagagaagt tcagatcaag gtcaggaaca gatggaacag     6420

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa     6480

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc     6540

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag     6600

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg     6660

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctcaat     6720

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg     6780

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct     6840

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca cacatgcagc     6900

atgtatcaaa attaatttgg ttttttttct taagtattta cattaaatgg ccatagtact     6960

taaagttaca ttggcttcct tgaaataaac atggagtatt cagaatgtgt cataaatatt     7020

tctaatttta agatagtatc tccattggct ttctactttt tcttttattt ttttttgtcc     7080

tctgtcttcc atttgttgtt gttgttgttt gtttgtttgt ttgttggttg gttggttaat     7140

ttttttttaa agatcctaca ctatagttca agctagacta ttagctactc tgtaacccag     7200

ggtgaccttg aagtcatggg tagcctgctg ttttagcctt cccacatcta agattacagg     7260

tatgagctat catttttggt atattgattg attgattgat tgatgtgtgt gtgtgtgatt     7320

gtgtttgtgt gtgtgactgt gaaaatgtgt gtatgggtgt gtgtgaatgt gtgtatgtat     7380

gtgtgtgtgt gagtgtgtgt gtgtgtgtgt gcatgtgtgt gtgtgtgact gtgtctatgt     7440

gtatgactgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgaa     7500

aaaatattct atggtagtga gagccaacgc tccggctcag gtgtcaggtt ggtttttgag     7560

acagagtctt tcacttagct tggaattcac tggccgtcgt tttacaacgt cgtgactggg     7620

aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc     7680

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg     7740

aatggcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat     7800

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     7860

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     7920

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     7980

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     8040

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     8100

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     8160

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     8220

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     8280

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     8340

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     8400

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     8460

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     8520

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     8580

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     8640

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     8700

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     8760

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     8820

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     8880

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     8940

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     9000

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     9060

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     9120

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     9180

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     9240

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     9300

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     9360

ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     9420

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     9480

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     9540

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     9600

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     9660

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     9720

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     9780

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     9840

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     9900

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     9960

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt    10020

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc    10080

gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc    10140

ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct    10200

atgaccatga ttacgccaag ctttgctctt aggagtttcc taatacatcc caaactcaaa    10260

tatataaagc atttgacttg ttctatgccc tagggggcgg ggggaagcta agccagcttt    10320

ttttaacatt taaaatgtta attccatttt aaatgcacag atgtttttat ttcataaggg    10380

tttcaatgtg catgaatgct gcaatattcc tgttaccaaa gctagtataa ataaaaatag    10440

ataaacgtgg aaattactta gagtttctgt cattaacgtt tccttcctca gttgacaaca    10500

taaatgcgct gctgagcaag ccagtttgca tctgtcagga tcaatttccc attatgccag    10560

tcatattaat tactagtcaa ttagttgatt tttatttttg acatatacat gtg           10613


<210>  45
<211>  10616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-hROR1-Ev3-CAR

<400>  45
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggac ttagttggct tttcctcgtc     3180

gccatactca aaggtgtaca atgctcacgc gatatacaaa tgacgcagag tccatcctca     3240

ctgtctgcct cagtaggcga cagggtcaca ataacctgta aagcaagccc ggatatcaac     3300

tcttacctca gttggttcca acagaaacca ggaaaggtgc cgaagttgtt gatttaccgc     3360

gcaaaccgcc tcgttgacgg cgtgccagat aggttttctg gcagcgggag cggcactgac     3420

tttacgctca ctatatcaag cctgcagccg gaggacgtag caacttacta ttgcctccaa     3480

tacgacgaat tcccttacac gttcgggcaa ggaactaaag ttgaaataaa aagaggaagc     3540

acaagtggtt ctggaaaacc cggttccggt gagggcagta ccaaaggaga ggtgcagttg     3600

gtagagtctg gtgggggttt ggtgcaaccc ggagggtctc tgaggttgtc ttgcgcggca     3660

tccggcttta ctttttcctc atatgcgatg tcatgggtac gacaggcccc aggcaaggga     3720

ctggagtgga tcgcatctat ttcacgagga gggacgacat attacccgga ttcagtgaag     3780

ggcaaattca taatttcacg cgataacgcc aagaactccc tctacctgca aatgaacagt     3840

cttagagcgg aagatacggc tgtgtattac tgtgcgcgat atgactacga tggatattac     3900

gcgatggatt attggggaca aggtacactg gtaaccgttt ccagctacgt caccgtctct     3960

tcacaggatc ccgccctgga agagaagaaa ggcaattacg tcgtgaccga ccacggcagc     4020

tgtgtgcggg cttgtggcgc cgatagctac gagatggaag aggacggcgt gcggaagtgc     4080

aagaagtgcg agggcccctg cagaaaagtg tgcaacggca tcggcatcgg agagttcaag     4140

gatagcctga gcatcaacgc caccaacatc aagcacttca agaactgcac cagcatcagc     4200

ggcgacctgc acatcctgcc cgtggccttt agaggcgaca gcttcaccca caccccccca     4260

ctggatcccc aggaactgga catcctgaaa accgtgaaag agatcacagg ctttctgctg     4320

attcaggcct ggcccgagaa ccggacagac ctgcacgcct tcgagaacct ggaaatcatc     4380

agaggccgga ccaagcagca cggccagttt tctctggccg tggtgtccct gaacatcacc     4440

agcctgggcc tgcggagcct gaaagaaatc agcgacggcg acgtgatcat ctccggcaac     4500

aagaacctgt gctacgccaa caccatcaat tggaagaagc tgttcggcac ctccggccag     4560

aaaacaaaga tcatctctaa ccggggcgag aacagctgca aagccaccgg acaagtgtgc     4620

cacgccctgt gtagccctga gggctgttgg ggacccgagc ccagagattg cgtgtcctgc     4680

cggaatgtgt ccagaggccg cgagtgcgtg gacaagtgca acctgctgga aggcgagccc     4740

cgcgagtttg tggaaaacag cgagtgcatc cagtgccacc ccgagtgtct gccccaggcc     4800

atgaacatta cctgcaccgg cagaggcccc gacaactgta tccagtgcgc ccactacatc     4860

gacggccccc actgcgtgaa aacctgtcca gctggcgtga tgggagagaa caacaccctc     4920

gtgtggaagt acgccgacgc cggccatgtg tgccacctgt gtcaccccaa ttgcacctac     4980

ggctgtaccg gccctggcct ggaaggctgt cctaccaacg gccccaagat cccttctaaa     5040

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     5100

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     5160

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     5220

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     5280

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     5340

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     5400

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     5460

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     5520

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     5580

ccccctcgcg gaccgcagtg tactaattat gctctcttga aattggctgg agatgttgag     5640

agcaatcccg ggcccatgcg gatcagcaag ccccacctgc ggagcatcag catccagtgc     5700

tacctgtgcc tgctgctgaa cagccacttc ctgaccgagg ccggcatcca cgtgttcatc     5760

ctgggctgct tcagcgccgg actgcccaag accgaggcca actgggtgaa cgtgatcagc     5820

gacctgaaga agatcgagga cctgatccag agcatgcaca tcgacgccac cctgtacacc     5880

gagagcgacg tgcaccccag ctgcaaggtg accgccatga agtgctttct gctggaactg     5940

caggtgatca gcctggaaag cggcgacgcc agcatccacg acaccgtgga gaacctgatc     6000

atcctggcca acaacagcct gagcagcaac ggcaacgtga ccgagagcgg ctgcaaagag     6060

tgcgaggaac tggaagagaa gaacatcaaa gagtttctgc agagcttcgt gcacatcgtg     6120

cagatgttca tcaacaccag ctgacgcgtc atcatcgatc cggattagtc caatttgtta     6180

aagacaggat atcagtggtc caggctctag ttttgactca acaatatcac cagctgaagc     6240

ctatagagta cgagccatag ataaaataaa agattttatt tagtctccag aaaaaggggg     6300

gaatgaaaga ccccacctgt aggtttggca agctagctta agtaacgcca ttttgcaagg     6360

catggaaaaa tacataactg agaatagaga agttcagatc aaggtcagga acagatggaa     6420

cagctgaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc     6480

caagaacaga tggaacagct gaatatgggc caaacaggat atctgtggta agcagttcct     6540

gccccggctc agggccaaga acagatggtc cccagatgcg gtccagccct cagcagtttc     6600

tagagaacca tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat     6660

ttgaactaac caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc     6720

aataaaagag cccacaaccc ctcactcggg gcgccagtcc tccgattgac tgagtcgccc     6780

gggtacccgt gtatccaata aaccctcttg cagttgcatc cgacttgtgg tctcgctgtt     6840

ccttgggagg gtctcctctg agtgattgac tacccgtcag cgggggtctt tcacacatgc     6900

agcatgtatc aaaattaatt tggttttttt tcttaagtat ttacattaaa tggccatagt     6960

acttaaagtt acattggctt ccttgaaata aacatggagt attcagaatg tgtcataaat     7020

atttctaatt ttaagatagt atctccattg gctttctact ttttctttta tttttttttg     7080

tcctctgtct tccatttgtt gttgttgttg tttgtttgtt tgtttgttgg ttggttggtt     7140

aatttttttt taaagatcct acactatagt tcaagctaga ctattagcta ctctgtaacc     7200

cagggtgacc ttgaagtcat gggtagcctg ctgttttagc cttcccacat ctaagattac     7260

aggtatgagc tatcattttt ggtatattga ttgattgatt gattgatgtg tgtgtgtgtg     7320

attgtgtttg tgtgtgtgac tgtgaaaatg tgtgtatggg tgtgtgtgaa tgtgtgtatg     7380

tatgtgtgtg tgtgagtgtg tgtgtgtgtg tgtgcatgtg tgtgtgtgtg actgtgtcta     7440

tgtgtatgac tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt     7500

gaaaaaatat tctatggtag tgagagccaa cgctccggct caggtgtcag gttggttttt     7560

gagacagagt ctttcactta gcttggaatt cactggccgt cgttttacaa cgtcgtgact     7620

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     7680

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     7740

gcgaatggcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca     7800

tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc     7860

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac     7920

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac     7980

gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa     8040

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt     8100

tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc     8160

ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc     8220

ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa     8280

aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg     8340

gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag     8400

ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc     8460

gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta     8520

cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg     8580

cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca     8640

acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac     8700

caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat     8760

taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg     8820

ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata     8880

aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta     8940

agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa     9000

atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag     9060

tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg     9120

tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact     9180

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg     9240

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc     9300

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata     9360

ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta     9420

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc     9480

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg     9540

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac     9600

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     9660

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     9720

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     9780

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg     9840

ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata     9900

accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca     9960

gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc    10020

gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg    10080

agcgcaacgc aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta    10140

tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca    10200

gctatgacca tgattacgcc aagctttgct cttaggagtt tcctaataca tcccaaactc    10260

aaatatataa agcatttgac ttgttctatg ccctaggggg cggggggaag ctaagccagc    10320

tttttttaac atttaaaatg ttaattccat tttaaatgca cagatgtttt tatttcataa    10380

gggtttcaat gtgcatgaat gctgcaatat tcctgttacc aaagctagta taaataaaaa    10440

tagataaacg tggaaattac ttagagtttc tgtcattaac gtttccttcc tcagttgaca    10500

acataaatgc gctgctgagc aagccagttt gcatctgtca ggatcaattt cccattatgc    10560

cagtcatatt aattactagt caattagttg atttttattt ttgacatata catgtg        10616


<210>  46
<211>  10610
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

pSFG4-CD5-Ev3-CAR

<400>  46
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggct tgagttggtt gttccttgtg     3180

gcgatactca aaggcgttca atgtagccga gacataaaaa tgacccagtc tccgtcatct     3240

atgtatgcaa gcctcggcga gcgagtgacc atcacgtgca aggcgagtca agatataaac     3300

agctacttgt catggttcca acaaaaacca gggaaatcac ctaagaccct gatctataga     3360

gccaatcgcc tggttgacgg tgtcccctcc cgctttagcg gctccggaag cggtcaagat     3420

tactctctca caatttcttc cttggattat gaagacatgg ggatctacta ttgtcaacag     3480

tatgacgaat ccccgtggac tttcggtggc ggtaccaaat tggaaataaa gggctctaca     3540

agcggctcag gaaaacctgg atcaggcgaa gggtctacga agggccagat acaactcgtt     3600

caaagtgggc cagaactcaa aaaaccggga gaaacagtga aaatttcttg taaggcatca     3660

ggatacacat tcacaaacta cgggatgaat tgggtcaaac aagcacccgg aaaggggctg     3720

cgctggatgg ggtggatcaa cacacatact ggggaaccta cttacgcaga cgatttcaag     3780

ggcagattcg ccttttcttt ggagacctcc gcctctactg catacttgca gataaacaac     3840

ctgaagaatg aagataccgc cacctacttc tgtacgcgca ggggctacga ttggtatttt     3900

gatgtatggg gggcaggcac cactgttact gtgtcaagct acgtcaccgt ctcttcacag     3960

gatcccgccc tggaagagaa gaaaggcaat tacgtcgtga ccgaccacgg cagctgtgtg     4020

cgggcttgtg gcgccgatag ctacgagatg gaagaggacg gcgtgcggaa gtgcaagaag     4080

tgcgagggcc cctgcagaaa agtgtgcaac ggcatcggca tcggagagtt caaggatagc     4140

ctgagcatca acgccaccaa catcaagcac ttcaagaact gcaccagcat cagcggcgac     4200

ctgcacatcc tgcccgtggc ctttagaggc gacagcttca cccacacccc cccactggat     4260

ccccaggaac tggacatcct gaaaaccgtg aaagagatca caggctttct gctgattcag     4320

gcctggcccg agaaccggac agacctgcac gccttcgaga acctggaaat catcagaggc     4380

cggaccaagc agcacggcca gttttctctg gccgtggtgt ccctgaacat caccagcctg     4440

ggcctgcgga gcctgaaaga aatcagcgac ggcgacgtga tcatctccgg caacaagaac     4500

ctgtgctacg ccaacaccat caattggaag aagctgttcg gcacctccgg ccagaaaaca     4560

aagatcatct ctaaccgggg cgagaacagc tgcaaagcca ccggacaagt gtgccacgcc     4620

ctgtgtagcc ctgagggctg ttggggaccc gagcccagag attgcgtgtc ctgccggaat     4680

gtgtccagag gccgcgagtg cgtggacaag tgcaacctgc tggaaggcga gccccgcgag     4740

tttgtggaaa acagcgagtg catccagtgc caccccgagt gtctgcccca ggccatgaac     4800

attacctgca ccggcagagg ccccgacaac tgtatccagt gcgcccacta catcgacggc     4860

ccccactgcg tgaaaacctg tccagctggc gtgatgggag agaacaacac cctcgtgtgg     4920

aagtacgccg acgccggcca tgtgtgccac ctgtgtcacc ccaattgcac ctacggctgt     4980

accggccctg gcctggaagg ctgtcctacc aacggcccca agatcccttc taaagatccc     5040

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     5100

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     5160

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     5220

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     5280

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     5340

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     5400

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     5460

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     5520

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     5580

cgcggaccgc agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaat     5640

cccgggccca tgcggatcag caagccccac ctgcggagca tcagcatcca gtgctacctg     5700

tgcctgctgc tgaacagcca cttcctgacc gaggccggca tccacgtgtt catcctgggc     5760

tgcttcagcg ccggactgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg     5820

aagaagatcg aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc     5880

gacgtgcacc ccagctgcaa ggtgaccgcc atgaagtgct ttctgctgga actgcaggtg     5940

atcagcctgg aaagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg     6000

gccaacaaca gcctgagcag caacggcaac gtgaccgaga gcggctgcaa agagtgcgag     6060

gaactggaag agaagaacat caaagagttt ctgcagagct tcgtgcacat cgtgcagatg     6120

ttcatcaaca ccagctgacg cgtcatcatc gatccggatt agtccaattt gttaaagaca     6180

ggatatcagt ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag     6240

agtacgagcc atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga     6300

aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga     6360

aaaatacata actgagaata gagaagttca gatcaaggtc aggaacagat ggaacagctg     6420

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     6480

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     6540

gctcagggcc aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga     6600

accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac     6660

taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctcaataaa     6720

agagcccaca acccctcact cggggcgcca gtcctccgat tgactgagtc gcccgggtac     6780

ccgtgtatcc aataaaccct cttgcagttg catccgactt gtggtctcgc tgttccttgg     6840

gagggtctcc tctgagtgat tgactacccg tcagcggggg tctttcacac atgcagcatg     6900

tatcaaaatt aatttggttt tttttcttaa gtatttacat taaatggcca tagtacttaa     6960

agttacattg gcttccttga aataaacatg gagtattcag aatgtgtcat aaatatttct     7020

aattttaaga tagtatctcc attggctttc tactttttct tttatttttt tttgtcctct     7080

gtcttccatt tgttgttgtt gttgtttgtt tgtttgtttg ttggttggtt ggttaatttt     7140

tttttaaaga tcctacacta tagttcaagc tagactatta gctactctgt aacccagggt     7200

gaccttgaag tcatgggtag cctgctgttt tagccttccc acatctaaga ttacaggtat     7260

gagctatcat ttttggtata ttgattgatt gattgattga tgtgtgtgtg tgtgattgtg     7320

tttgtgtgtg tgactgtgaa aatgtgtgta tgggtgtgtg tgaatgtgtg tatgtatgtg     7380

tgtgtgtgag tgtgtgtgtg tgtgtgtgca tgtgtgtgtg tgtgactgtg tctatgtgta     7440

tgactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa     7500

atattctatg gtagtgagag ccaacgctcc ggctcaggtg tcaggttggt ttttgagaca     7560

gagtctttca cttagcttgg aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa     7620

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     7680

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     7740

ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     7800

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     7860

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     7920

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     7980

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     8040

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     8100

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     8160

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     8220

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     8280

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     8340

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     8400

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     8460

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     8520

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     8580

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     8640

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     8700

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     8760

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     8820

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     8880

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     8940

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     9000

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     9060

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     9120

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     9180

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     9240

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     9300

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     9360

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     9420

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     9480

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     9540

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     9600

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     9660

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     9720

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     9780

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     9840

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     9900

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     9960

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    10020

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    10080

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    10140

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    10200

accatgatta cgccaagctt tgctcttagg agtttcctaa tacatcccaa actcaaatat    10260

ataaagcatt tgacttgttc tatgccctag ggggcggggg gaagctaagc cagctttttt    10320

taacatttaa aatgttaatt ccattttaaa tgcacagatg tttttatttc ataagggttt    10380

caatgtgcat gaatgctgca atattcctgt taccaaagct agtataaata aaaatagata    10440

aacgtggaaa ttacttagag tttctgtcat taacgtttcc ttcctcagtt gacaacataa    10500

atgcgctgct gagcaagcca gtttgcatct gtcaggatca atttcccatt atgccagtca    10560

tattaattac tagtcaatta gttgattttt atttttgaca tatacatgtg               10610


<210>  47
<211>  10610
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-hCD5-Ev3-CAR

<400>  47
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagttcggtc tcagttggct gtttttggtt     3180

gctatcttga agggcgtcca atgcagccgg gacatccaga tgacccagtc tccctctagc     3240

atgtcagcga gtcttggtga tcgagtgacg attacctgca gagcctctca agatataaac     3300

agctatcttt catggttcca acagaagccg gggaagtccc caaaaactct catatacagg     3360

gcgaatcgac tcgtagacgg tgtgccttca aggttttccg ggagtggtag tggcacagat     3420

tacacactta caatctcttc attgcagtat gaggatttcg ggatctacta ctgtcaacag     3480

tacgacgaat ccccatggac gtttgggggc gggaccaaac ttgagataaa agggagcaca     3540

tctggaagtg gtaaacctgg gtcaggggag ggttccacaa aaggacaaat tcaacttgtc     3600

caaagcggtc ctggtcttaa gaagcctgga gggtctgtca ggataagttg tgcggcatcc     3660

ggctacacct tcaccaacta tgggatgaac tgggtgaaac aagcgcctgg gaaaggtctt     3720

cgatggatgg gctggattaa tacccacact ggagagccca cttacgctga tgatttcaaa     3780

ggacgattta ccttctcctt ggatacttcc aagagtaccg cgtacttgca aatcaacagt     3840

ctccgggctg aagacacggc cacatacttc tgtacgcgga gagggtatga ctggtatttt     3900

gatgtgtggg gtcagggaac aaccgtgact gtttcaagct acgtcaccgt ctcttcacag     3960

gatcccgccc tggaagagaa gaaaggcaat tacgtcgtga ccgaccacgg cagctgtgtg     4020

cgggcttgtg gcgccgatag ctacgagatg gaagaggacg gcgtgcggaa gtgcaagaag     4080

tgcgagggcc cctgcagaaa agtgtgcaac ggcatcggca tcggagagtt caaggatagc     4140

ctgagcatca acgccaccaa catcaagcac ttcaagaact gcaccagcat cagcggcgac     4200

ctgcacatcc tgcccgtggc ctttagaggc gacagcttca cccacacccc cccactggat     4260

ccccaggaac tggacatcct gaaaaccgtg aaagagatca caggctttct gctgattcag     4320

gcctggcccg agaaccggac agacctgcac gccttcgaga acctggaaat catcagaggc     4380

cggaccaagc agcacggcca gttttctctg gccgtggtgt ccctgaacat caccagcctg     4440

ggcctgcgga gcctgaaaga aatcagcgac ggcgacgtga tcatctccgg caacaagaac     4500

ctgtgctacg ccaacaccat caattggaag aagctgttcg gcacctccgg ccagaaaaca     4560

aagatcatct ctaaccgggg cgagaacagc tgcaaagcca ccggacaagt gtgccacgcc     4620

ctgtgtagcc ctgagggctg ttggggaccc gagcccagag attgcgtgtc ctgccggaat     4680

gtgtccagag gccgcgagtg cgtggacaag tgcaacctgc tggaaggcga gccccgcgag     4740

tttgtggaaa acagcgagtg catccagtgc caccccgagt gtctgcccca ggccatgaac     4800

attacctgca ccggcagagg ccccgacaac tgtatccagt gcgcccacta catcgacggc     4860

ccccactgcg tgaaaacctg tccagctggc gtgatgggag agaacaacac cctcgtgtgg     4920

aagtacgccg acgccggcca tgtgtgccac ctgtgtcacc ccaattgcac ctacggctgt     4980

accggccctg gcctggaagg ctgtcctacc aacggcccca agatcccttc taaagatccc     5040

aaattttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     5100

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     5160

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     5220

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     5280

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     5340

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     5400

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     5460

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     5520

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     5580

cgcggaccgc agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaat     5640

cccgggccca tgcggatcag caagccccac ctgcggagca tcagcatcca gtgctacctg     5700

tgcctgctgc tgaacagcca cttcctgacc gaggccggca tccacgtgtt catcctgggc     5760

tgcttcagcg ccggactgcc caagaccgag gccaactggg tgaacgtgat cagcgacctg     5820

aagaagatcg aggacctgat ccagagcatg cacatcgacg ccaccctgta caccgagagc     5880

gacgtgcacc ccagctgcaa ggtgaccgcc atgaagtgct ttctgctgga actgcaggtg     5940

atcagcctgg aaagcggcga cgccagcatc cacgacaccg tggagaacct gatcatcctg     6000

gccaacaaca gcctgagcag caacggcaac gtgaccgaga gcggctgcaa agagtgcgag     6060

gaactggaag agaagaacat caaagagttt ctgcagagct tcgtgcacat cgtgcagatg     6120

ttcatcaaca ccagctgacg cgtcatcatc gatccggatt agtccaattt gttaaagaca     6180

ggatatcagt ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag     6240

agtacgagcc atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga     6300

aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga     6360

aaaatacata actgagaata gagaagttca gatcaaggtc aggaacagat ggaacagctg     6420

aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa     6480

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg     6540

gctcagggcc aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga     6600

accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac     6660

taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctcaataaa     6720

agagcccaca acccctcact cggggcgcca gtcctccgat tgactgagtc gcccgggtac     6780

ccgtgtatcc aataaaccct cttgcagttg catccgactt gtggtctcgc tgttccttgg     6840

gagggtctcc tctgagtgat tgactacccg tcagcggggg tctttcacac atgcagcatg     6900

tatcaaaatt aatttggttt tttttcttaa gtatttacat taaatggcca tagtacttaa     6960

agttacattg gcttccttga aataaacatg gagtattcag aatgtgtcat aaatatttct     7020

aattttaaga tagtatctcc attggctttc tactttttct tttatttttt tttgtcctct     7080

gtcttccatt tgttgttgtt gttgtttgtt tgtttgtttg ttggttggtt ggttaatttt     7140

tttttaaaga tcctacacta tagttcaagc tagactatta gctactctgt aacccagggt     7200

gaccttgaag tcatgggtag cctgctgttt tagccttccc acatctaaga ttacaggtat     7260

gagctatcat ttttggtata ttgattgatt gattgattga tgtgtgtgtg tgtgattgtg     7320

tttgtgtgtg tgactgtgaa aatgtgtgta tgggtgtgtg tgaatgtgtg tatgtatgtg     7380

tgtgtgtgag tgtgtgtgtg tgtgtgtgca tgtgtgtgtg tgtgactgtg tctatgtgta     7440

tgactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa     7500

atattctatg gtagtgagag ccaacgctcc ggctcaggtg tcaggttggt ttttgagaca     7560

gagtctttca cttagcttgg aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa     7620

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     7680

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     7740

ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     7800

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     7860

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     7920

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     7980

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     8040

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     8100

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     8160

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     8220

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     8280

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     8340

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     8400

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     8460

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     8520

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     8580

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     8640

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     8700

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     8760

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     8820

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     8880

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     8940

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     9000

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     9060

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     9120

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     9180

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     9240

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     9300

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     9360

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     9420

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     9480

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     9540

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     9600

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     9660

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     9720

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     9780

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     9840

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     9900

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     9960

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc    10020

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca    10080

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc    10140

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg    10200

accatgatta cgccaagctt tgctcttagg agtttcctaa tacatcccaa actcaaatat    10260

ataaagcatt tgacttgttc tatgccctag ggggcggggg gaagctaagc cagctttttt    10320

taacatttaa aatgttaatt ccattttaaa tgcacagatg tttttatttc ataagggttt    10380

caatgtgcat gaatgctgca atattcctgt taccaaagct agtataaata aaaatagata    10440

aacgtggaaa ttacttagag tttctgtcat taacgtttcc ttcctcagtt gacaacataa    10500

atgcgctgct gagcaagcca gtttgcatct gtcaggatca atttcccatt atgccagtca    10560

tattaattac tagtcaatta gttgattttt atttttgaca tatacatgtg               10610


<210>  48
<211>  10274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-CD19-DAP12-CAR

<400>  48
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catgctcgag ggagtgcagg tggaaaccat ctccccagga     1920

gacgggcgca ccttccccaa gcgcggccag acctgcgtgg tgcactacac cgggatgctt     1980

gaagatggaa agaaagttga ttcctcccgg gacagaaaca agccctttaa gtttatgcta     2040

ggcaagcagg aggtgatccg aggctgggaa gaaggggttg cccagatgag tgtgggtcag     2100

agagccaaac tgactatatc tccagattat gcctatggtg ccactgggca cccaggcatc     2160

atcccaccac atgccactct cgtcttcgat gtggagcttc taaaactgga atctggcggt     2220

ggatccggag tcgacggatt tggtgatgtc ggtgctcttg agagtttgag gggaaatgca     2280

gatttggctt acatcctgag catggagccc tgtggccact gcctcattat caacaatgtg     2340

aacttctgcc gtgagtccgg gctccgcacc cgcactggct ccaacatcga ctgtgagaag     2400

ttgcggcgtc gcttctcctc gctgcatttc atggtggagg tgaagggcga cctgactgcc     2460

aagaaaatgg tgctggcttt gctggagctg gcgcagcagg accacggtgc tctggactgc     2520

tgcgtggtgg tcattctctc tcacggctgt caggccagcc acctgcagtt cccaggggct     2580

gtctacggca cagatggatg ccctgtgtcg gtcgagaaga ttgtgaacat cttcaatggg     2640

accagctgcc ccagcctggg agggaagccc aagctctttt tcatccaggc ctgtggtggg     2700

gagcagaaag accatgggtt tgaggtggcc tccacttccc ctgaagacga gtcccctggc     2760

agtaaccccg agccagatgc caccccgttc caggaaggtt tgaggacctt cgaccagctg     2820

gacgccatat ctagtttgcc cacacccagt gacatctttg tgtcctactc tactttccca     2880

ggttttgttt cctggaggga ccccaagagt ggctcctggt acgttgagac cctggacgac     2940

atctttgagc agtgggctca ctctgaagac ctgcagtccc tcctgcttag ggtcgctaat     3000

gctgtttcgg tgaaagggat ttataaacag atgcctggtt gctttaattt cctccggaaa     3060

aaacttttct ttaaaacatc agctagcaga gccgagggca ggggaagtct tctaacatgc     3120

ggggacgtgg aggaaaatcc cgggcccatg gagtttgggc tgagctggct ttttcttgtg     3180

gctattttaa aaggtgtcca gtgctctaga gacatccaga tgacacagac tacatcctcc     3240

ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattagt     3300

aaatatttaa attggtatca gcagaaacca gatggaactg ttaaactcct gatctaccat     3360

acatcaagat tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat     3420

tattctctca ccattagcaa cctggagcaa gaagatattg ccacttactt ttgccaacag     3480

ggtaatacgc ttccgtacac gttcggaggg gggaccaagc tggagctgaa acgtggtggt     3540

ggtggttctg gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg atccgaggtg     3600

cagctgcagc agtctggacc tggcctggtg gcgccctcac agagcctgtc cgtcacatgc     3660

actgtctcag gggtctcatt acccgactat ggtgtaagct ggattcgcca gcctccacga     3720

aagggtctgg agtggctggg agtaatatgg ggtagtgaaa ccacatacta taattcagct     3780

ctcaaatcca gactgaccat catcaaggac aactccaaga gccaagtttt cttaaaaatg     3840

aacagtctgc aaactgatga cacagccatt tactactgtg ccaaacatta ttactacggt     3900

ggtagctatg ctatggacta ctggggccaa gggaccacgg tcaccgtctc ctcgtacgtc     3960

accgtctctt cacaggatcc cgccgagccc aaatctcctg acaaaactca cacatgccca     4020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     4080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     4140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     4200

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     4260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     4320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     4380

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     4440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcaaccg     4500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     4560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     4620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     4680

aaagatccca aaggcgtgct ggccggaatc gtgatgggcg acctggtgct gacagtgctg     4740

atcgccctgg ctgtgtactt cctgggcaga ctggtgccca gaggaagagg cgctgccgaa     4800

gccgccaccc ggaagcagag aatcaccgag acagagagcc cctatcagga actgcagggc     4860

cagcggagcg acgtgtacag cgacctgaat acccagcggc cctactacaa gagagtgaag     4920

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     4980

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     5040

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     5100

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     5160

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     5220

cttcacatgc aggccctgcc ccctcgcgga ccgcagtgta ctaattatgc tctcttgaaa     5280

ttggctggag atgttgagag caatcccggg cccatgcgga tcagcaagcc ccacctgcgg     5340

agcatcagca tccagtgcta cctgtgcctg ctgctgaaca gccacttcct gaccgaggcc     5400

ggcatccacg tgttcatcct gggctgcttc agcgccggac tgcccaagac cgaggccaac     5460

tgggtgaacg tgatcagcga cctgaagaag atcgaggacc tgatccagag catgcacatc     5520

gacgccaccc tgtacaccga gagcgacgtg caccccagct gcaaggtgac cgccatgaag     5580

tgctttctgc tggaactgca ggtgatcagc ctggaaagcg gcgacgccag catccacgac     5640

accgtggaga acctgatcat cctggccaac aacagcctga gcagcaacgg caacgtgacc     5700

gagagcggct gcaaagagtg cgaggaactg gaagagaaga acatcaaaga gtttctgcag     5760

agcttcgtgc acatcgtgca gatgttcatc aacaccagct gacgcgtcat catcgatccg     5820

gattagtcca atttgttaaa gacaggatat cagtggtcca ggctctagtt ttgactcaac     5880

aatatcacca gctgaagcct atagagtacg agccatagat aaaataaaag attttattta     5940

gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag ctagcttaag     6000

taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag ttcagatcaa     6060

ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt     6120

cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca aacaggatat     6180

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     6240

ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     6300

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     6360

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc gccagtcctc     6420

cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca gttgcatccg     6480

acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta cccgtcagcg     6540

ggggtctttc acacatgcag catgtatcaa aattaatttg gttttttttc ttaagtattt     6600

acattaaatg gccatagtac ttaaagttac attggcttcc ttgaaataaa catggagtat     6660

tcagaatgtg tcataaatat ttctaatttt aagatagtat ctccattggc tttctacttt     6720

ttcttttatt tttttttgtc ctctgtcttc catttgttgt tgttgttgtt tgtttgtttg     6780

tttgttggtt ggttggttaa ttttttttta aagatcctac actatagttc aagctagact     6840

attagctact ctgtaaccca gggtgacctt gaagtcatgg gtagcctgct gttttagcct     6900

tcccacatct aagattacag gtatgagcta tcatttttgg tatattgatt gattgattga     6960

ttgatgtgtg tgtgtgtgat tgtgtttgtg tgtgtgactg tgaaaatgtg tgtatgggtg     7020

tgtgtgaatg tgtgtatgta tgtgtgtgtg tgagtgtgtg tgtgtgtgtg tgcatgtgtg     7080

tgtgtgtgac tgtgtctatg tgtatgactg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     7140

tgtgtgtgtg tgtgttgtga aaaaatattc tatggtagtg agagccaacg ctccggctca     7200

ggtgtcaggt tggtttttga gacagagtct ttcacttagc ttggaattca ctggccgtcg     7260

ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac     7320

atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac     7380

agttgcgcag cctgaatggc gaatggcgcc tgatgcggta ttttctcctt acgcatctgt     7440

gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt     7500

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     7560

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     7620

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     7680

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc     7740

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     7800

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt     7860

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     7920

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     7980

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     8040

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     8100

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     8160

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     8220

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     8280

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     8340

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     8400

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     8460

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     8520

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     8580

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     8640

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     8700

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     8760

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     8820

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     8880

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     8940

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     9000

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga     9060

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     9120

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     9180

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     9240

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     9300

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     9360

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     9420

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     9480

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     9540

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     9600

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca     9660

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg     9720

actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac     9780

cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac     9840

aatttcacac aggaaacagc tatgaccatg attacgccaa gctttgctct taggagtttc     9900

ctaatacatc ccaaactcaa atatataaag catttgactt gttctatgcc ctagggggcg     9960

gggggaagct aagccagctt tttttaacat ttaaaatgtt aattccattt taaatgcaca    10020

gatgttttta tttcataagg gtttcaatgt gcatgaatgc tgcaatattc ctgttaccaa    10080

agctagtata aataaaaata gataaacgtg gaaattactt agagtttctg tcattaacgt    10140

ttccttcctc agttgacaac ataaatgcgc tgctgagcaa gccagtttgc atctgtcagg    10200

atcaatttcc cattatgcca gtcatattaa ttactagtca attagttgat ttttattttt    10260

gacatataca tgtg                                                      10274


<210>  49
<211>  9374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSFG4-CD19-DAP12-Ev3-CAR 2.0

<400>  49
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaaat acataactga gaatagaaaa gttcagatca aggtcaggaa cagatggaac      120

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      180

aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg      240

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct      300

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt      360

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttatgctc cccgagctca      420

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      480

ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc      540

cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt catttggggg      600

ctcgtccggg atcgggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      660

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgactga ttttatgcgc      720

ctgcgtcggt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac      780

gagttcggaa cacccggccg caaccctggg agacgtccca gggacttcgg gggccgtttt      840

tgtggcccga cctgagtcct aaaatcccga tcgtttagga ctctttggtg cacccccctt      900

agaggaggga tatgtggttc tggtaggaga cgagaaccta aaacagttcc cgcctccgtc      960

tgaatttttg ctttcggttt gggaccgaag ccgcgccgcg cgtcttgtct gctgcagcat     1020

cgttctgtgt tgtctctgtc tgactgtgtt tctgtatttg tctgaaaata tgggcccggg     1080

ctagcctgtt accactccct taagtttgac cttaggtcac tggaaagatg tcgagcggat     1140

cgctcacaac cagtcggtag atgtcaagaa gagacgttgg gttaccttct gctctgcaga     1200

atggccaacc tttaacgtcg gatggccgcg agacggcacc tttaaccgag acctcatcac     1260

ccaggttaag atcaaggtct tttcacctgg cccgcatgga cacccagacc aggtggggta     1320

catcgtgacc tgggaagcct tggcttttga cccccctccc tgggtcaagc cctttgtaca     1380

ccctaagcct ccgcctcctc ttcctccatc cgccccgtct ctcccccttg aacctcctcg     1440

ttcgaccccg cctcgatcct ccctttatcc agccctcact ccttctctag gcgcccccat     1500

atggccatat gagatcttat atggggcacc cccgcccctt gtaaacttcc ctgaccctga     1560

catgacaaga gttactaaca gcccctctct ccaagctcac ttacaggctc tctacttagt     1620

ccagcacgaa gtctggagac ctctggcggc agcctaccaa gaacaactgg accgaccggt     1680

ggtacctcac ccttaccgag tcggcgacac agtgtgggtc cgccgacacc agactaagaa     1740

cctagaacct cgctggaaag gaccttacac agtcctgctg accaccccca ccgccctcaa     1800

agtagacggc atcgcagctt ggatacacgc cgcccacgtg aaggctgccg accccggggg     1860

tggaccatcc tctagactgc catggagttt gggctgagct ggctttttct tgtggctatt     1920

ttaaaaggtg tccagtgctc tagagacatc cagatgacac agactacatc ctccctgtct     1980

gcctctctgg gagacagagt caccatcagt tgcagggcaa gtcaggacat tagtaaatat     2040

ttaaattggt atcagcagaa accagatgga actgttaaac tcctgatcta ccatacatca     2100

agattacact caggagtccc atcaaggttc agtggcagtg ggtctggaac agattattct     2160

ctcaccatta gcaacctgga gcaagaagat attgccactt acttttgcca acagggtaat     2220

acgcttccgt acacgttcgg aggggggacc aagctggagc tgaaacgtgg tggtggtggt     2280

tctggtggtg gtggttctgg cggcggcggc tccggtggtg gtggatccga ggtgcagctg     2340

cagcagtctg gacctggcct ggtggcgccc tcacagagcc tgtccgtcac atgcactgtc     2400

tcaggggtct cattacccga ctatggtgta agctggattc gccagcctcc acgaaagggt     2460

ctggagtggc tgggagtaat atggggtagt gaaaccacat actataattc agctctcaaa     2520

tccagactga ccatcatcaa ggacaactcc aagagccaag ttttcttaaa aatgaacagt     2580

ctgcaaactg atgacacagc catttactac tgtgccaaac attattacta cggtggtagc     2640

tatgctatgg actactgggg ccaagggacc acggtcaccg tctcctcgta cgtcaccgtc     2700

tcttcacagg atcccgccct ggaagagaag aaaggcaatt acgtcgtgac cgaccacggc     2760

agctgtgtgc gggcttgtgg cgccgatagc tacgagatgg aagaggacgg cgtgcggaag     2820

tgcaagaagt gcgagggccc ctgcagaaaa gtgtgcaacg gcatcggcat cggagagttc     2880

aaggatagcc tgagcatcaa cgccaccaac atcaagcact tcaagaactg caccagcatc     2940

agcggcgacc tgcacatcct gcccgtggcc tttagaggcg acagcttcac ccacaccccc     3000

ccactggatc cccaggaact ggacatcctg aaaaccgtga aagagatcac aggctttctg     3060

ctgattcagg cctggcccga gaaccggaca gacctgcacg ccttcgagaa cctggaaatc     3120

atcagaggcc ggaccaagca gcacggccag ttttctctgg ccgtggtgtc cctgaacatc     3180

accagcctgg gcctgcggag cctgaaagaa atcagcgacg gcgacgtgat catctccggc     3240

aacaagaacc tgtgctacgc caacaccatc aattggaaga agctgttcgg cacctccggc     3300

cagaaaacaa agatcatctc taaccggggc gagaacagct gcaaagccac cggacaagtg     3360

tgccacgccc tgtgtagccc tgagggctgt tggggacccg agcccagaga ttgcgtgtcc     3420

tgccggaatg tgtccagagg ccgcgagtgc gtggacaagt gcaacctgct ggaaggcgag     3480

ccccgcgagt ttgtggaaaa cagcgagtgc atccagtgcc accccgagtg tctgccccag     3540

gccatgaaca ttacctgcac cggcagaggc cccgacaact gtatccagtg cgcccactac     3600

atcgacggcc cccactgcgt gaaaacctgt ccagctggcg tgatgggaga gaacaacacc     3660

ctcgtgtgga agtacgccga cgccggccat gtgtgccacc tgtgtcaccc caattgcacc     3720

tacggctgta ccggccctgg cctggaaggc tgtcctacca acggccccaa gatccctagc     3780

aaggatccta agggagtgct ggccggaatc gtgatgggcg acctggtgct gacagtgctg     3840

atcgccctgg ctgtgtactt cctgggcaga ctggtgccca gaggaagagg cgctgccgaa     3900

gccgccaccc ggaagcagag aatcaccgag acagagagcc cctatcagga actgcagggc     3960

cagcggagcg acgtgtacag cgacctgaat acccagcggc cctactacaa gagagtgaag     4020

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     4080

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     4140

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     4200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     4260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     4320

cttcacatgc aggccctgcc ccctcgcgga ccgcagtgta ctaattatgc tctcttgaaa     4380

ttggctggag atgttgagag caatcccggg cccatgcgga tcagcaagcc ccacctgcgg     4440

agcatcagca tccagtgcta cctgtgcctg ctgctgaaca gccacttcct gaccgaggcc     4500

ggcatccacg tgttcatcct gggctgcttc agcgccggac tgcccaagac cgaggccaac     4560

tgggtgaacg tgatcagcga cctgaagaag atcgaggacc tgatccagag catgcacatc     4620

gacgccaccc tgtacaccga gagcgacgtg caccccagct gcaaggtgac cgccatgaag     4680

tgctttctgc tggaactgca ggtgatcagc ctggaaagcg gcgacgccag catccacgac     4740

accgtggaga acctgatcat cctggccaac aacagcctga gcagcaacgg caacgtgacc     4800

gagagcggct gcaaagagtg cgaggaactg gaagagaaga acatcaaaga gtttctgcag     4860

agcttcgtgc acatcgtgca gatgttcatc aacaccagct gacgcgtcat catcgatccg     4920

gattagtcca atttgttaaa gacaggatat cagtggtcca ggctctagtt ttgactcaac     4980

aatatcacca gctgaagcct atagagtacg agccatagat aaaataaaag attttattta     5040

gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag ctagcttaag     5100

taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag ttcagatcaa     5160

ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt     5220

cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca aacaggatat     5280

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     5340

ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     5400

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     5460

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc gccagtcctc     5520

cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca gttgcatccg     5580

acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta cccgtcagcg     5640

ggggtctttc acacatgcag catgtatcaa aattaatttg gttttttttc ttaagtattt     5700

acattaaatg gccatagtac ttaaagttac attggcttcc ttgaaataaa catggagtat     5760

tcagaatgtg tcataaatat ttctaatttt aagatagtat ctccattggc tttctacttt     5820

ttcttttatt tttttttgtc ctctgtcttc catttgttgt tgttgttgtt tgtttgtttg     5880

tttgttggtt ggttggttaa ttttttttta aagatcctac actatagttc aagctagact     5940

attagctact ctgtaaccca gggtgacctt gaagtcatgg gtagcctgct gttttagcct     6000

tcccacatct aagattacag gtatgagcta tcatttttgg tatattgatt gattgattga     6060

ttgatgtgtg tgtgtgtgat tgtgtttgtg tgtgtgactg tgaaaatgtg tgtatgggtg     6120

tgtgtgaatg tgtgtatgta tgtgtgtgtg tgagtgtgtg tgtgtgtgtg tgcatgtgtg     6180

tgtgtgtgac tgtgtctatg tgtatgactg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     6240

tgtgtgtgtg tgtgttgtga aaaaatattc tatggtagtg agagccaacg ctccggctca     6300

ggtgtcaggt tggtttttga gacagagtct ttcacttagc ttggaattca ctggccgtcg     6360

ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac     6420

atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac     6480

agttgcgcag cctgaatggc gaatggcgcc tgatgcggta ttttctcctt acgcatctgt     6540

gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt     6600

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     6660

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     6720

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     6780

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc     6840

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     6900

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt     6960

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     7020

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     7080

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     7140

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     7200

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     7260

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     7320

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     7380

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     7440

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     7500

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     7560

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     7620

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     7680

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     7740

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     7800

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     7860

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     7920

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     7980

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     8040

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     8100

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga     8160

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     8220

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     8280

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     8340

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     8400

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     8460

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     8520

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     8580

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     8640

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     8700

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca     8760

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg     8820

actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac     8880

cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac     8940

aatttcacac aggaaacagc tatgaccatg attacgccaa gctttgctct taggagtttc     9000

ctaatacatc ccaaactcaa atatataaag catttgactt gttctatgcc ctagggggcg     9060

gggggaagct aagccagctt tttttaacat ttaaaatgtt aattccattt taaatgcaca     9120

gatgttttta tttcataagg gtttcaatgt gcatgaatgc tgcaatattc ctgttaccaa     9180

agctagtata aataaaaata gataaacgtg gaaattactt agagtttctg tcattaacgt     9240

ttccttcctc agttgacaac ataaatgcgc tgctgagcaa gccagtttgc atctgtcagg     9300

atcaatttcc cattatgcca gtcatattaa ttactagtca attagttgat ttttattttt     9360

gacatataca tgtg                                                       9374


<210>  50
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSFG4-CD19-DAP12-Ev3-CAR 2.0

<400>  50

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Tyr Val Thr 
            260                 265                 270         


Val Ser Ser Gln Asp Pro Ala Leu Glu Glu Lys Lys Gly Asn Tyr Val 
        275                 280                 285             


Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr 
    290                 295                 300                 


Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro 
305                 310                 315                 320 


Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
                325                 330                 335     


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
            340                 345                 350         


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
        355                 360                 365             


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
    370                 375                 380                 


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
385                 390                 395                 400 


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
                405                 410                 415     


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
            420                 425                 430         


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
        435                 440                 445             


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
    450                 455                 460                 


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
465                 470                 475                 480 


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
                485                 490                 495     


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
            500                 505                 510         


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
        515                 520                 525             


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
    530                 535                 540                 


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
545                 550                 555                 560 


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
                565                 570                 575     


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
            580                 585                 590         


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
        595                 600                 605             


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
    610                 615                 620                 


Pro Thr Asn Gly Pro Lys Ile Pro Ser Lys Asp Pro Lys Gly Val Leu 
625                 630                 635                 640 


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
                645                 650                 655     


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
            660                 665                 670         


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
        675                 680                 685             


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
    690                 695                 700                 


Gln Arg Pro Tyr Tyr Lys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
705                 710                 715                 720 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                725                 730                 735     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            740                 745                 750         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        755                 760                 765             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    770                 775                 780                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
785                 790                 795                 800 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                805                 810                 815     


Gln Ala Leu Pro Pro Arg Gly Pro Gln Cys Thr Asn Tyr Ala Leu Leu 
            820                 825                 830         


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Arg Ile Ser 
        835                 840                 845             


Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
    850                 855                 860                 


Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
865                 870                 875                 880 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
                885                 890                 895     


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
            900                 905                 910         


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
        915                 920                 925             


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
    930                 935                 940                 


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
945                 950                 955                 960 


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
                965                 970                 975     


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
            980                 985                 990         


Gln Ser Phe Val His Ile Val Gln  Met Phe Ile Asn Thr  Ser 
        995                 1000                 1005     


<210>  51
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DAP12

<400>  51
ggcgtgctgg ccggaatcgt gatgggcgac ctggtgctga cagtgctgat cgccctggct       60

gtgtacttcc tgggcagact ggtgcccaga ggaagaggcg ctgccgaagc cgccacccgg      120

aagcagagaa tcaccgagac agagagcccc tatcaggaac tgcagggcca gcggagcgac      180

gtgtacagcg acctgaatac ccagcggccc tactacaag                             219


<210>  52
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP12

<400>  52

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
            20                  25                  30          


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
        35                  40                  45              


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
    50                  55                  60                  


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
65                  70              


<210>  53
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta

<400>  53
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgcggac cg                         342


<210>  54
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta

<400>  54

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


Gly Pro 
        


<210>  55
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL15

<400>  55
atgcggatca gcaagcccca cctgcggagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggactgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc tttctgctgg aactgcaggt gatcagcctg      300

gaaagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aagagtgcga ggaactggaa      420

gagaagaaca tcaaagagtt tctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagctga                                                              489


<210>  56
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL15

<400>  56

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  57
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCLL-1 scFv

<400>  57
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgctcg       60

cgagacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagagtg      120

accatcacct gcagagccag cagcaacgtg atcagcagct acgtgcactg gtaccagcag      180

aagcccggca aggcccccaa gctgctgatc tacagcacca gcaacctggc cagcggcgtg      240

cccagcagat tcagcggcag cagaagcggc accgacttca ccctgaccat cagcagcctg      300

cagcccgagg acttcgccac ctactactgc cagcagtaca gcggctaccc cctgaccttc      360

ggccagggca ccaaggtgga gatcaagaga ggtggtggtg gttctggtgg tggtggttct      420

ggcggcggcg gctccggtgg tggtggatcc gaggtgcagc tggtggagag cggcggcggc      480

ctggtgcagc ccggcggcag cctgagactg agctgcgccg ccagcggcta cagcatcacc      540

agcgcctact actggaactg ggtgagacag gcccccggca agggcctgga gtgggtggcc      600

tacatcagct acgacggcag aaacaactac aaccccagcc tgaagaacag attcaccatc      660

agcgccgaca ccagcaagaa caccgcctac ctgcagatga acagcctgag agccgaggac      720

accgccgtgt actactgcag cagagagggc gactacgacg tgggcaacta ctacgccatg      780

gactactggg gccagggcac cctggtgacc gtgagctcg                             819


<210>  58
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCLL-1 scFv

<400>  58

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser 
        35                  40                  45              


Asn Val Ile Ser Ser Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Ser Gly Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Tyr Ser Ile Thr Ser Ala Tyr Tyr Trp Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Tyr Asp Gly Arg Asn 
        195                 200                 205             


Asn Tyr Asn Pro Ser Leu Lys Asn Arg Phe Thr Ile Ser Ala Asp Thr 
    210                 215                 220                 


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Arg Glu Gly Asp Tyr Asp Val Gly Asn 
                245                 250                 255     


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser 
    


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCLL1 VH

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  60
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCLL1 VL

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD99 scFv

<400>  61
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgctct       60

agaagcagcg agctgaccca ggaccccgcc gtgagcgtgg ccctgggcca gaccgtgaga      120

atcacctgcc agggcgacag cctgagaagc tactacgcca gctggtacca gcagaagccc      180

ggccaggccc ccgtgctggt gatctacggc aagaacaaca gacccagcgg catccccgac      240

agattcagcg gcagcagcag cggcaacacc gccagcctga ccatcaccgg cgcccaggcc      300

gaggacgagg ccgactacta ctgcaacagc agcttcccca gaaccagcag cgtggtgttc      360

ggcggcggca ccaagctgac cgtgctgggc ggtggtggtg gttctggtgg tggtggttct      420

ggcggcggcg gctccggtgg tggtggatcc atggccgagg tgcagctggt ggagagcggc      480

ggcggcctgg tgagacccgg cggcagcctg agactgagct gcgccgccag cggcttcacc      540

ttcagcagct acgccatgag ctgggtgaga caggcccccg gcaagggcct ggagtgggtg      600

agcgccatca gcggcagcgg cggcagcacc tactacgccg acagcgtgaa gggcagattc      660

accatcagca gagacaacag caagaacacc ctgtacctgc agatgaacag cctgagagcc      720

gaggacaccg ccgtgtacta ctgcgccaag agccacaaga gattcgacta ctggggccag      780

ggcaccctgg tgaccgtgag caga                                             804


<210>  62
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD99 scFv

<400>  62

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser 
            20                  25                  30          


Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 
        35                  40                  45              


Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 
                85                  90                  95      


Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Phe 
            100                 105                 110         


Pro Arg Thr Ser Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Met Ala Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
        195                 200                 205             


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser His Lys Arg Phe Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
            260                 265             


<210>  63
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD99 VH

<400>  63

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Phe Pro Arg Thr Ser Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  64
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD99 VL

<400>  64

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser His Lys Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg 
        115             


