                         SEQUENCE LISTING

<110>  SUTRO BIOPHARMA, INC.
 
<120>  METHODS OF USING ANTI-CD74 ANTIBODIES AND ANTIBODY CONJUGATES IN 
       TREATMENT OF T-CELL LYMPHOMA

<130>  108843.00151

<150>  US 62/537,377
<151>  2017-07-26

<160>  314   

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, CDR-H1

<400>  1

Gly Phe Asn Phe Ser Asp Tyr 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-H1

<400>  2

Gly Phe Thr Phe Asn Asn Asn 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-H1

<400>  3

Gly Phe Thr Phe Asn Asn Thr 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-H1

<400>  4

Gly Phe Thr Phe Thr Ser Ser 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, CDR-H1

<400>  5

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, CDR-H1

<400>  6

Gly Phe Asn Ile Ser Gly Ser 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, CDR-H1

<400>  7

Gly Phe Asn Ile Asn Asn Tyr 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, CDR-H1

<400>  8

Gly Phe Asn Ile Asn Asn Tyr 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, CDR-H1

<400>  9

Gly Phe Ala Phe Ser Asp His 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, CDR-H1

<400>  10

Gly Phe Ala Phe Ser Asp His 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, CDR-H1

<400>  11

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-H1

<400>  12

Gly Phe Thr Phe Thr Gly Asn 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, CDR-H1

<400>  13

Gly Phe Asn Phe Ser Asp Tyr 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, CDR-H1

<400>  14

Gly Phe Asn Phe Ser Ser His 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, CDR-H1

<400>  15

Gly Phe Asn Phe Ser Ser Tyr 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, CDR-H1

<400>  16

Gly Phe Ser Phe Ala Ser His 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, CDR-H1

<400>  17

Gly Phe Ser Phe Gly Ser Tyr 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, CDR-H1

<400>  18

Gly Phe Ser Phe Ser Ser Tyr 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, CDR-H1

<400>  19

Gly Phe Thr Phe Asp Ser Tyr 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, CDR-H1

<400>  20

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, CDR-H1

<400>  21

Gly Phe Thr Phe Ser Ser His 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, CDR-H1

<400>  22

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, CDR-H1

<400>  23

Gly Phe Asn Ile Ser Gly Tyr 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, CDR-H1

<400>  24

Gly Phe Asn Ile Thr Gly Thr 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-H1

<400>  25

Gly Phe Thr Phe Asn Asn Thr 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-H1

<400>  26

Gly Phe Thr Phe Asn Asp Thr 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-H1

<400>  27

Gly Phe Thr Phe Asp Asn Thr 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-H1

<400>  28

Gly Phe Thr Phe Asn Thr Ser 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], CDR-H1

<400>  29

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], CDR-H1

<400>  30

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], CDR-H1

<400>  31

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], CDR-H1

<400>  32

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, CDR-H1

<400>  33

Asp Tyr Gly Met His 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-H1

<400>  34

Asn Asn Trp Met Ser 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-H1

<400>  35

Asn Thr Asp Met Ser 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-H1

<400>  36

Ser Ser Trp Met Ser 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, CDR-H1

<400>  37

Asp Tyr Asp Met Ser 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, CDR-H1

<400>  38

Gly Ser Trp Ile His 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, CDR-H1

<400>  39

Asn Tyr Asp Ile His 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, CDR-H1

<400>  40

Asn Tyr Asp Ile His 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, CDR-H1

<400>  41

Asp His Gly Met His 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, CDR-H1

<400>  42

Asp His Gly Met His 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, CDR-H1

<400>  43

Ser Tyr Gly Met His 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-H1

<400>  44

Gly Asn Trp Met Ser 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, CDR-H1

<400>  45

Asp Tyr Gly Met His 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, CDR-H1

<400>  46

Ser His Gly Met His 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, CDR-H1

<400>  47

Ser Tyr Gly Met His 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, CDR-H1

<400>  48

Ser His Gly Met His 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, CDR-H1

<400>  49

Ser Tyr Gly Met His 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, CDR-H1

<400>  50

Ser Tyr Gly Met His 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, CDR-H1

<400>  51

Ser Tyr Gly Met His 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, CDR-H1

<400>  52

Ser Phe Gly Met His 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, CDR-H1

<400>  53

Ser His Gly Met His 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, CDR-H1

<400>  54

Ser Tyr Gly Met His 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, CDR-H1

<400>  55

Gly Tyr Tyr Ile His 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, CDR-H1

<400>  56

Gly Thr Gly Ile His 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-H1

<400>  57

Asn Thr Asp Met Ser 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-H1

<400>  58

Asp Thr Asp Met Ser 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-H1

<400>  59

Asn Thr Asp Met Ser 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-H1

<400>  60

Thr Ser Asp Met Ser 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], CDR-H1

<400>  61

Ser Tyr Gly Met His 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], CDR-H1

<400>  62

Ser Tyr Ala Met His 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], CDR-H1

<400>  63

Ser Tyr Ala Met His 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], CDR-H1

<400>  64

Ser Tyr Ala Met His 
1               5   


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, CDR-H2

<400>  65

Trp Tyr Asp Gly Ser Ile 
1               5       


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-H2

<400>  66

Asn Gly Asp Asp Gly Tyr 
1               5       


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-H2

<400>  67

Asn Gly Ser Gly Gly Ala 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-H2

<400>  68

Asn Gly Tyr Asn Gly Ile 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, CDR-H2

<400>  69

Ala Gln Asp Gly Ser Tyr 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, CDR-H2

<400>  70

Tyr Pro Asp Asp Gly Asp 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, CDR-H2

<400>  71

Asp Pro Tyr Asn Gly Ala 
1               5       


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, CDR-H2

<400>  72

Asp Pro Tyr Asn Gly Thr 
1               5       


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, CDR-H2

<400>  73

Trp Tyr Asp Gly Ser His 
1               5       


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, CDR-H2

<400>  74

Trp Tyr Asp Gly Ser His 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, CDR-H2

<400>  75

Trp Asp Asp Gly Ser Asp 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-H2

<400>  76

Tyr Gly Thr Ser Gly Ala 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, CDR-H2

<400>  77

Trp Tyr Asp Gly Ser Arg 
1               5       


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, CDR-H2

<400>  78

Trp His Asp Gly Ser Asp 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, CDR-H2

<400>  79

Trp Tyr Asp Gly Ser Ile 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, CDR-H2

<400>  80

Trp Asp Asp Gly Ser Asp 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, CDR-H2

<400>  81

Trp Tyr Asp Gly Ser Lys 
1               5       


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, CDR-H2

<400>  82

Trp Tyr Asp Ala Ser Ile 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, CDR-H2

<400>  83

Trp Tyr Asp Gly Ser Asn 
1               5       


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, CDR-H2

<400>  84

Trp Tyr Asp Gly Ser Asn 
1               5       


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, CDR-H2

<400>  85

Trp Asp Asp Gly Ser Asn 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, CDR-H2

<400>  86

Trp His Asp Gly Ser Lys 
1               5       


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, CDR-H2

<400>  87

Ser Pro Thr Gly Gly Tyr 
1               5       


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, CDR-H2

<400>  88

Thr Pro Tyr Asn Gly Thr 
1               5       


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-H2

<400>  89

Asn Gly Ser Gly Gly Ser 
1               5       


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-H2

<400>  90

Asn Gly Ala Gly Gly Ala 
1               5       


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-H2

<400>  91

Asn Gly Ser Gly Gly Val 
1               5       


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-H2

<400>  92

Asn Gly Ser Gly Gly Ala 
1               5       


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], CDR-H2

<400>  93

Trp Tyr Asp Gly Ser Asn 
1               5       


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], CDR-H2

<400>  94

Ser Tyr Asp Gly Ser Asn 
1               5       


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], CDR-H2

<400>  95

Ser Tyr Asp Gly Ser Ile 
1               5       


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], CDR-H2

<400>  96

Ser Tyr Asp Gly Ser Asn 
1               5       


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, CDR-H2

<400>  97

Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-H2

<400>  98

Ile Ile Asn Gly Asp Asp Gly Tyr Thr Tyr Tyr Ala Asp Arg Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-H2

<400>  99

Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-H2

<400>  100

Ile Ile Asn Gly Tyr Asn Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, CDR-H2

<400>  101

Phe Ile Ala Gln Asp Gly Ser Tyr Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, CDR-H2

<400>  102

Tyr Ile Tyr Pro Asp Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, CDR-H2

<400>  103

Asn Ile Asp Pro Tyr Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, CDR-H2

<400>  104

Asn Ile Asp Pro Tyr Asn Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, CDR-H2

<400>  105

Val Ile Trp Tyr Asp Gly Ser His Lys Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, CDR-H2

<400>  106

Val Ile Trp Tyr Asp Gly Ser His Lys Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, CDR-H2

<400>  107

Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-H2

<400>  108

Ile Ile Tyr Gly Thr Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, CDR-H2

<400>  109

Val Thr Trp Tyr Asp Gly Ser Arg Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, CDR-H2

<400>  110

Val Ile Trp His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, CDR-H2

<400>  111

Val Ile Trp Tyr Asp Gly Ser Ile Lys Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, CDR-H2

<400>  112

Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, CDR-H2

<400>  113

Val Val Trp Tyr Asp Gly Ser Lys Thr Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, CDR-H2

<400>  114

Val Ile Trp Tyr Asp Ala Ser Ile Arg Lys Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, CDR-H2

<400>  115

Val Ile Trp Tyr Asp Gly Ser Asn Lys Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, CDR-H2

<400>  116

Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, CDR-H2

<400>  117

Val Ile Trp Asp Asp Gly Ser Asn Glu Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, CDR-H2

<400>  118

Val Ile Trp His Asp Gly Ser Lys Asp Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, CDR-H2

<400>  119

Glu Ile Ser Pro Thr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, CDR-H2

<400>  120

Ile Ile Thr Pro Tyr Asn Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-H2

<400>  121

Val Ile Asn Gly Ser Gly Gly Ser Ser Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-H2

<400>  122

Met Ile Asn Gly Ala Gly Gly Ala Ser Phe Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-H2

<400>  123

Ile Ile Asn Gly Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-H2

<400>  124

Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], CDR-H2

<400>  125

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], CDR-H2

<400>  126

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], CDR-H2

<400>  127

Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], CDR-H2

<400>  128

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, CDR-H3

<400>  129

Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-H3

<400>  130

Val Ala Leu Gly Arg Pro Arg Arg Phe Asp Tyr 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-H3

<400>  131

Phe Glu Asn Glu Trp Glu Val Ser Met Asp Tyr 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-H3

<400>  132

Pro Ser Ala Pro Gly Ala Arg Arg Phe Asp Tyr 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, CDR-H3

<400>  133

Ser Lys Leu Phe Arg Ala Gly Gln Phe Asp Tyr 
1               5                   10      


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, CDR-H3

<400>  134

Glu Gly Ser His Asn Leu Asp Lys Met Asp Tyr 
1               5                   10      


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, CDR-H3

<400>  135

Val Leu Trp Gly Phe Trp Ala Pro Phe Asp Tyr 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, CDR-H3

<400>  136

Val Pro Trp Gly Phe Trp Ala Pro Phe Asp Tyr 
1               5                   10      


<210>  137
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, CDR-H3

<400>  137

Gly Gly Ser Leu Ala Gly Gly Ala Val Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  138
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, CDR-H3

<400>  138

Gly Gly Ser Leu Ala Gly Gly Ala Val Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, CDR-H3

<400>  139

Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp Val 
1               5                   10                  


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-H3

<400>  140

Pro Ser Met Ser Gly Ser Arg Gly Phe Asp Tyr 
1               5                   10      


<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, CDR-H3

<400>  141

Gly Gly Thr Leu Val His Gly Ala Leu Tyr Gly Asn Asp Val 
1               5                   10                  


<210>  142
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, CDR-H3

<400>  142

Gly Gly Thr Arg Val Leu Gly Ala Val Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  143
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, CDR-H3

<400>  143

Gly Gly Ala Leu Met Arg Gly Glu Phe Ser Gly His Asp Val 
1               5                   10                  


<210>  144
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, CDR-H3

<400>  144

Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp Val 
1               5                   10                  


<210>  145
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, CDR-H3

<400>  145

Gly Gly Thr Leu Val Arg Gly Ala Val Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  146
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, CDR-H3

<400>  146

Gly Gly Thr Val Glu Arg Gly Ala Ile Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  147
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, CDR-H3

<400>  147

Gly Gly Met Val Gly Gln Gly Ala Met Phe Gly Leu Asp Val 
1               5                   10                  


<210>  148
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, CDR-H3

<400>  148

Gly Gly Ser Leu Val Thr Arg Gly Val Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  149
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, CDR-H3

<400>  149

Gly Gly Thr Arg Ile Arg Gly Leu Arg Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  150
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, CDR-H3

<400>  150

Gly Gly Gln Leu Asp His Gly Ala Ile Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  151
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, CDR-H3

<400>  151

Glu His Gly Leu Val Tyr Gly Gln Pro Met Asp Tyr 
1               5                   10          


<210>  152
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, CDR-H3

<400>  152

Gly Gly Tyr Gly Tyr Tyr Tyr Pro Pro Phe Asp Tyr 
1               5                   10          


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-H3

<400>  153

Tyr Glu Thr Glu Trp Glu Val Ser Leu Asp Tyr 
1               5                   10      


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-H3

<400>  154

Phe Glu Asn Gln Trp Glu Val Thr Phe Asp Tyr 
1               5                   10      


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-H3

<400>  155

Tyr Glu Ser Glu Trp Glu Val Ser Leu Asp Tyr 
1               5                   10      


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-H3

<400>  156

Tyr Glu Asn Glu Met Glu Val Ser Met Asp Tyr 
1               5                   10      


<210>  157
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], CDR-H3

<400>  157

Gly Gly Thr Leu Val Arg Gly Ala Met Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], CDR-H3

<400>  158

Gly Arg Tyr Tyr Gly Ser Gly Ser Tyr Ser Ser Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], CDR-H3

<400>  159

Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp Tyr 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], CDR-H3

<400>  160

Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp Tyr 
1               5                   10                  15  


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09, CDR-L1

<400>  161

Arg Ala Ser Gln Gly Ile Gly Ser Trp Leu Ala 
1               5                   10      


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-L1

<400>  162

Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-L1

<400>  163

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-L1

<400>  164

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10, CDR-L1

<400>  165

Arg Ala Ser Gln Gly Val Ser Ser Trp Leu Ala 
1               5                   10      


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D01, CDR-L1

<400>  166

Arg Ala Ser Gln Gly Ile Gly Arg Trp Leu Ala 
1               5                   10      


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D10, CDR-L1

<400>  167

Arg Ala Ser Gln Gly Val Phe Ser Trp Leu Ala 
1               5                   10      


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-G02, CDR-L1

<400>  168

Arg Ala Ser Gln Gly Leu Gly Ser Phe Leu Ala 
1               5                   10      


<210>  169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A04, CDR-L1

<400>  169

Arg Ala Ser Gln Asp Ile Gly Arg Trp Val Ala 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A05, CDR-L1

<400>  170

Arg Ala Ser Gln Gly Ile Gly Arg Trp Val Ala 
1               5                   10      


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A06, CDR-L1

<400>  171

Arg Ala Ser Gln Asp Ile Gly Ser Trp Val Ala 
1               5                   10      


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07, CDR-L1

<400>  172

Arg Ala Ser Gln Gly Ile Ser Ser Trp Val Ala 
1               5                   10      


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A08, CDR-L1

<400>  173

Arg Ala Ser Gln Asp Ile Gly Ser Trp Val Ala 
1               5                   10      


<210>  174
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-L1

<400>  174

Arg Ala Gly Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10, CDR-L1

<400>  175

Arg Ala Ser Gln Gly Ile Ser Ser Trp Val Ala 
1               5                   10      


<210>  176
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-L1

<400>  176

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  177
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-L1

<400>  177

Arg Ala Ser Gln Arg Val Ala Gly Ile Asp Leu Ser 
1               5                   10          


<210>  178
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-L1

<400>  178

Arg Ala Ser Gln Ser Val Tyr Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  179
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-L1

<400>  179

Arg Ala Ser Gln Ser Val Ser Ser Arg Glu Leu Gly 
1               5                   10          


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL-5[23] & VL6-[26], CDR-L1

<400>  180

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09, CDR-L2

<400>  181

Ala Ala Asp Arg Leu Gln Ser 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-L2

<400>  182

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-L2

<400>  183

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-L2

<400>  184

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  185
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10, CDR-L2

<400>  185

Ser Ala Arg Tyr Leu Gln Ser 
1               5           


<210>  186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D01, CDR-L2

<400>  186

Gly Arg Ser Ser Leu Gln Ser 
1               5           


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D10, CDR-L2

<400>  187

Asn Ala Thr Gln Leu Gln Ser 
1               5           


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-G02, CDR-L2

<400>  188

Leu Gly Asn Leu Leu Gln Ile 
1               5           


<210>  189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A04, CDR-L2

<400>  189

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A05, CDR-L2

<400>  190

Gly Ala Asp Arg Leu Gln Ser 
1               5           


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A06, CDR-L2

<400>  191

Gly Ala Asp Arg Leu Gln Ser 
1               5           


<210>  192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07, CDR-L2

<400>  192

Gly Ala Ser Arg Leu Gln Ser 
1               5           


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A08, CDR-L2

<400>  193

Ala Ser Asp Ser Leu Gln Ser 
1               5           


<210>  194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-L2

<400>  194

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10, CDR-L2

<400>  195

Gly Ser Ser Arg Leu Gln Ser 
1               5           


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-L2

<400>  196

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-L2

<400>  197

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-L2

<400>  198

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-L2

<400>  199

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL-5[23] & VL6-[26], CDR-L2

<400>  200

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09, CDR-L3

<400>  201

Gln Gln Tyr His Thr Tyr Pro Leu Thr 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, CDR-L3

<400>  202

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, CDR-L3

<400>  203

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, CDR-L3

<400>  204

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10, CDR-L3

<400>  205

Gln Gln Tyr Asn Leu Tyr Pro Leu Thr 
1               5                   


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D01, CDR-L3

<400>  206

Gln Gln Tyr Asn Ile Tyr Pro Leu Thr 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D10, CDR-L3

<400>  207

Gln Gln Tyr Tyr Tyr Tyr Pro Leu Thr 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-G02, CDR-L3

<400>  208

Gln Gln Tyr Asn Ala Tyr Pro Leu Thr 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A04, CDR-L3

<400>  209

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A05, CDR-L3

<400>  210

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A06, CDR-L3

<400>  211

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07, CDR-L3

<400>  212

Gln Gln Tyr His Thr Tyr Pro Leu Thr 
1               5                   


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A08, CDR-L3

<400>  213

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, CDR-L3

<400>  214

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10, CDR-L3

<400>  215

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, CDR-L3

<400>  216

Gln His Asn Gln Pro Thr Pro Pro Thr 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, CDR-L3

<400>  217

Gln Gln His Asn Thr Thr Pro Pro Thr 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, CDR-L3

<400>  218

Gln Gln His Gln Thr Ala Pro Pro Thr 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, CDR-L3

<400>  219

Gln Gln Gln Cys Ser Trp Pro Pro Thr 
1               5                   


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL-5[23] & VL6-[26], CDR-L3

<400>  220

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  221
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, scFv

<400>  221

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Gly Thr Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Met Ser Gly Ser Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Gly Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  222
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, scFv

<400>  222

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Asp Asp Gly Tyr Thr Tyr Tyr Ala Asp Arg Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ile Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Leu Gly Arg Pro Arg Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Thr Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  223
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, scFv

<400>  223

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Glu Asn Glu Trp Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  224
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, scFv

<400>  224

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Tyr Asn Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Ala Pro Gly Ala Arg Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  225
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, scFv

<400>  225

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asn Gly Ser Gly Gly Ser Ser Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Thr Glu Trp Glu Val Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln His Asn Gln Pro Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  226
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, scFv

<400>  226

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asn Gly Ala Gly Gly Ala Ser Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Glu Asn Gln Trp Glu Val Thr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Arg Val Ala Gly Ile Asp Leu Ser Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Asn Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  227
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, scFv

<400>  227

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Ser Glu Trp Glu Val Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Tyr Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Gln Thr Ala Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  228
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, scFv

<400>  228

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Ser 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Asn Glu Met Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Arg Glu Leu Gly Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Gln Cys Ser Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  229
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08-g_1337-A09-g scFv-Fc, scFv-Fc

<400>  229

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Asp Arg Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Ala Ala Gly Ser Asp Gln Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  230
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-A01, VH

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Ala Gln Asp Gly Ser Tyr Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Leu Phe Arg Ala Gly Gln Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  231
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-B10, VH

<400>  231

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Gly Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asp Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser His Asn Leu Asp Lys Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  232
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D03, VH

<400>  232

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Asn Asn Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asp Pro Tyr Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Trp Gly Phe Trp Ala Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  233
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1198-D04, VH

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Asn Asn Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asp Pro Tyr Asn Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Trp Gly Phe Trp Ala Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  234
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A02, VH

<400>  234

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser His Lys Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Leu Ala Gly Gly Ala Val Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  235
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, VH

<400>  235

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser His Lys Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Leu Ala Gly Gly Ala Val Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  236
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08-g, VH

<400>  236

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  237
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06-g, VH

<400>  237

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  238
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08, VH

<400>  238

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Ala Thr Val Thr Val Ser Ser 
        115                 120             


<210>  239
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06, VH

<400>  239

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  240
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, VH

<400>  240

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Thr Trp Tyr Asp Gly Ser Arg Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Leu Val His Gly Ala Leu Tyr Gly Asn Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  241
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, VH

<400>  241

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Val Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  242
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-C03, VH

<400>  242

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Ile Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Leu Met Arg Gly Glu Phe Ser Gly His Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  243
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D02, VH

<400>  243

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ala Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  244
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D06, VH

<400>  244

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Gly Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Trp Tyr Asp Gly Ser Lys Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Leu Val Arg Gly Ala Val Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  245
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-D09, VH

<400>  245

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Ala Ser Ile Arg Lys Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Val Glu Arg Gly Ala Ile Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  246
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-E06, VH

<400>  246

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Met Val Gly Gln Gly Ala Met Phe Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  247
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F06, VH

<400>  247

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Leu Val Thr Arg Gly Val Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  248
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07, VH

<400>  248

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Asn Glu Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Arg Ile Arg Gly Leu Arg Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  249
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-G02, VH

<400>  249

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp His Asp Gly Ser Lys Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Leu Asp His Gly Ala Ile Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  250
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-A03, VH

<400>  250

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Pro Thr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Gly Leu Val Tyr Gly Gln Pro Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  251
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1445-B09, VH

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Thr Gly Thr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Thr Pro Tyr Asn Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Gly Tyr Tyr Tyr Pro Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  252
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH11-[19], VH

<400>  252

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Leu Val Arg Gly Ala Met Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  253
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH5-[7], VH

<400>  253

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Arg Tyr Tyr Gly Ser Gly Ser Tyr Ser Ser Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  254
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH6-[11], VH

<400>  254

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Thr Ser 
        115                 120                 


<210>  255
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH8-[15], VH

<400>  255

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  256
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09-g, VL

<400>  256

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  257
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10-g, VL

<400>  257

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Arg Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Leu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  258
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D01, VL

<400>  258

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  259
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-D10, VL

<400>  259

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Phe Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Asn Ala Thr Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  260
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-G02, VL

<400>  260

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Gly Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Leu Gly Asn Leu Leu Gln Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ala Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  261
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A04, VL

<400>  261

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Arg Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  262
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A05, VL

<400>  262

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Arg Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  263
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A06, VL

<400>  263

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  264
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07-g, VL

<400>  264

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  265
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07, VL

<400>  265

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  266
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A08, VL

<400>  266

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ser Asp Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  267
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09, VL

<400>  267

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  268
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10, VL

<400>  268

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Arg Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Leu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  269
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10, VL

<400>  269

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  270
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10-g, VL

<400>  270

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  271
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL5-[23], VL

<400>  271

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  272
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL6-[26], VL

<400>  272

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  273
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, VH

<400>  273

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Gly Thr Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Met Ser Gly Ser Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  274
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, VH

<400>  274

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Asp Asp Gly Tyr Thr Tyr Tyr Ala Asp Arg Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ile Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Leu Gly Arg Pro Arg Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  275
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, VH

<400>  275

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Glu Asn Glu Trp Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  276
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, VH

<400>  276

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Tyr Asn Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Ala Pro Gly Ala Arg Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  277
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, VH

<400>  277

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Asn Gly Ser Gly Gly Ser Ser Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Thr Glu Trp Glu Val Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  278
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, VH

<400>  278

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asn Gly Ala Gly Gly Ala Ser Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Glu Asn Gln Trp Glu Val Thr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  279
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, VH

<400>  279

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Ser Glu Trp Glu Val Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  280
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, VH

<400>  280

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Ser 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Gly Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Glu Asn Glu Met Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  281
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-B06, VL

<400>  281

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  282
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-C08, VL

<400>  282

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Thr Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  283
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-E06b, VL

<400>  283

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  284
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1193-H04b, VL

<400>  284

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  285
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-D11, VL

<400>  285

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Asn Gln Pro Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  286
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-E08, VL

<400>  286

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ala Gly Ile 
            20                  25                  30          


Asp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  287
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-F11, VL

<400>  287

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Gln Thr Ala Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  288
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1447-G01, VL

<400>  288

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Arg 
            20                  25                  30          


Glu Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gln Cys Ser Trp Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  289
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IgG1 Fc from scFv-Fc

<400>  289

Ala Ala Gly Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10                  15      


Cys Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
            20                  25                  30          


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        35                  40                  45              


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    50                  55                  60                  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
65                  70                  75                  80  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                85                  90                  95      


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            100                 105                 110         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        115                 120                 125             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235             


<210>  290
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Trastuzumab LC

<400>  290

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  291
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06-(wt), HC

<400>  291

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Ala Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  292
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06-(g), HC

<400>  292

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  293
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08-(wt), HC

<400>  293

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Ala Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  294
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B08-(g), HC

<400>  294

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Ile Ser Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Val Glu His Gly Ala Val Tyr Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  295
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10-(wt), LC

<400>  295

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Ser Ala Arg Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Leu Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  296
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1275-C10-(g), LC

<400>  296

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Arg Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Leu Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  297
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07-(wt), LC

<400>  297

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
            20                  25                  30          


Trp Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  298
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A07-(g), LC

<400>  298

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
            20                  25                  30          


Trp Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  299
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09-(wt), LC

<400>  299

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  300
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A09-(g), LC

<400>  300

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  301
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10-(wt), LC

<400>  301

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
            20                  25                  30          


Trp Val Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  302
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1337-A10-(g), LC

<400>  302

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
            20                  25                  30          


Trp Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: C-term His Tag

<400>  303

Gly Gly Ser His His His His His His 
1               5                   


<210>  304
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC Constant

<400>  304

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  305
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC Constant

<400>  305

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  306
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A03, HC

<400>  306

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp 
            20                  25                  30          


His Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser His Lys Ile Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Ser Leu Ala Gly Gly Ala Val Tyr Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Arg Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  307
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B09, HC

<400>  307

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asp 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Thr Trp Tyr Asp Gly Ser Arg Glu Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Leu Val His Gly Ala Leu Tyr Gly Asn Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  308
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-B10, HC

<400>  308

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Ser 
            20                  25                  30          


His Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Val Tyr Gly Leu Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Ser Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  309
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Fc Constant, Fc Constant

<400>  309

Ala Ala Gly Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10                  15      


Cys Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
            20                  25                  30          


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        35                  40                  45              


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    50                  55                  60                  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
65                  70                  75                  80  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                85                  90                  95      


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            100                 105                 110         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        115                 120                 125             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235             


<210>  310
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-A06 HC, HC

<400>  310

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Asp Asp Gly Ser Asp Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Arg Val Leu Gly Ala Ile His Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  311
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1251-F07 HC, HC

<400>  311

Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


His Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Asp Asp Gly Ser Asn Glu Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Arg Ile Arg Gly Leu Arg Tyr Gly Thr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  312
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: consensus sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is T, S, Q, M, or A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is R, L, or V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is V, E, A, G, I, D, or M

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X is R, L, H, G, Q, or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X is G or R

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X is A, L, E, or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is V, I, M, F, R, or L

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is Y, H, F, or S

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X is T, L, H, or N

<400>  312

Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Asp Val 
1               5                   10                  


<210>  313
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is I, T, or V

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is W or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is Y, D, or H

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X is G or A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X is N, I , D, H, K, or R

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is K, E, R, S, T, or D

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is Y, I, V, K, or N

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  X is D or G

<400>  313

Val Xaa Xaa Xaa Asp Xaa Ser Xaa Xaa Xaa Tyr Ala Xaa Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  314
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is I, T, or V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is Y, D, or H

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X is G or A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X is N, I , D, H, K, or R

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is K, E, R, S, T, or D

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is Y, I, V, K, or N

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  X is D or G

<400>  314

Val Xaa Trp Xaa Asp Xaa Ser Xaa Xaa Xaa Tyr Ala Xaa Ser Val Lys 
1               5                   10                  15      


Gly 
    


