                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Li,  Wei
       Liu, Xiaole
       Brown, Myles
       Peng, Jingyu
       Xiao, Tengfei
 
<120>  COMPOSITIONS AND METHODS FOR MAKING AND DECODING PAIRED-GUIDE RNA
        LIBRARIES AND USES THEREOF

<130>  52095-539001WO

<140>  PCT/US18/43588
<141>  2018-07-25

<150>  62/536,870
<151>  2017-07-25

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  2591
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  1
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg     1200

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1260

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1320

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1380

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1440

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1500

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1560

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1620

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1680

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1740

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1800

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1860

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1920

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     1980

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2040

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2100

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2160

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2220

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2280

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2340

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2400

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2460

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2520

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2580

tctgaggggt g                                                          2591


<210>  2
<211>  393
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  2

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  3
<211>  8718
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  3
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa     5580

ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag     5640

ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa     5700

aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact     5760

tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta     5820

gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt     5880

gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta     5940

ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc     6000

atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg     6060

ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt     6120

aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca     6180

gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa     6240

aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat     6300

cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga     6360

agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc     6420

tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag     6480

aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag     6540

acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc     6600

agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta     6660

gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa     6720

ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag     6780

atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa     6840

tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt     6900

ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac     6960

aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa     7020

tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc     7080

atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt     7140

aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa     7200

atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt     7260

tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca     7320

gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg     7380

tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata     7440

gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga     7500

attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc     7560

cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa     7620

ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa     7680

atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct     7740

gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata     7800

gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca     7860

atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac     7920

tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt     7980

ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt     8040

gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc     8100

tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg     8160

gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc     8220

ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta     8280

ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg     8340

tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt     8400

aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa     8460

tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt     8520

agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt     8580

tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa     8640

atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact     8700

aaaaaaaaaa aaaaaaaa                                                   8718


<210>  4
<211>  403
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  4

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  5
<211>  8626
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  5
acgacggggg aggtgctgta cgtccaagat ggcggcgccc tgtaggctgg agggactgtg       60

aggtaaacag ctgaggggga ggagacggtg gtgaccatga aagacaccag gttgacagca      120

ctggaaactg aagtaccagt tgtcgctaga acagtttggt agtggcccca atgaagaacc      180

ttcagaacct gtagcacacg tcctggagcc agcacagcgc cttcgagcga gagaatggcc      240

caacaagcaa atgtcgggga gcttcttgcc atgctggact cccccatgct gggtgtgcgg      300

gacgacgtga cagctgtctt taaagagaac ctcaattctg accgtggccc tatgcttgta      360

aacaccttgg tggattatta cctggaaacc agctctcagc cggcattgca catcctgacc      420

accttgcaag agccacatga caagcacctc ttggacagga ttaacgaata tgtgggcaaa      480

gccgccactc gtttatccat cctctcgtta ctgggtcatg tcataagact gcagccatct      540

tggaagcata agctctctca agcacctctt ttgccttctt tactaaaatg tctcaagatg      600

gacactgacg tcgttgtcct cacaacaggc gtcttggtgt tgataaccat gctaccaatg      660

attccacagt ctgggaaaca gcatcttctt gatttctttg acatttttgg ccgtctgtca      720

tcatggtgcc tgaagaaacc aggccacgtg gcggaagtct atctcgtcca tctccatgcc      780

agtgtgtacg cactctttca tcgcctttat ggaatgtacc cttgcaactt cgtctccttt      840

ttgcgttctc attacagtat gaaagaaaac ctggagactt ttgaagaagt ggtcaagcca      900

atgatggagc atgtgcgaat tcatccggaa ttagtgactg gatccaagga ccatgaactg      960

gaccctcgaa ggtggaagag attagaaact catgatgttg tgatcgagtg tgccaaaatc     1020

tctctggatc ccacagaagc ctcatatgaa gatggctatt ctgtgtctca ccaaatctca     1080

gcccgctttc ctcatcgttc agccgatgtc accaccagcc cttatgctga cacacagaat     1140

agctatgggt gtgctacttc taccccttac tccacgtctc ggctgatgtt gttaaatatg     1200

ccagggcagc tacctcagac tctgagttcc ccatcgacac ggctgataac tgaaccacca     1260

caagctactc tttggagccc atctatggtt tgtggtatga ccactcctcc aacttctcct     1320

ggaaatgtcc cacctgatct gtcacaccct tacagtaaag tctttggtac aactgcaggt     1380

ggaaaaggaa ctcctctggg aaccccagca acctctcctc ctccagcccc actctgtcat     1440

tcggatgact acgtgcacat ttcactcccc caggccacag tcacaccccc caggaaggaa     1500

gagagaatgg attctgcaag accatgtcta cacagacaac accatcttct gaatgacaga     1560

ggatcagaag agccacctgg cagcaaaggt tctgtcactc taagtgatct tccagggttt     1620

ttaggtgatc tggcctctga agaagatagt attgaaaaag ataaagaaga agctgcaata     1680

tctagagaac tttctgagat caccacagca gaggcagagc ctgtggttcc tcgaggaggc     1740

tttgactctc ccttttaccg agacagtctc ccaggttctc agcggaagac ccactcggca     1800

gcctccagtt ctcagggcgc cagcgtgaac cctgagcctt tacactcctc cctggacaag     1860

cttgggcctg acacaccaaa gcaagccttt actcccatag acctgccctg cggcagtgct     1920

gatgaaagcc ctgcgggaga cagggaatgc cagacttctt tggagaccag tatcttcact     1980

cccagtcctt gtaaaattcc acctccgacg agagtgggct ttggaagcgg gcagcctccc     2040

ccgtatgatc atctttttga ggtggcattg ccaaagacag cccatcattt tgtcatcagg     2100

aagactgagg agctgttaaa gaaagcaaaa ggaaacacag aggaagatgg tgtgccctct     2160

acctccccaa tggaagtgct ggacagactg atacagcagg gagcagacgc gcacagcaag     2220

gagctgaaca agttgccttt acccagcaag tctgtcgact ggacccactt tggaggctct     2280

cctccttcag atgagatccg caccctccga gaccagttgc ttttactgca caaccagtta     2340

ctctatgagc gttttaagag gcagcagcat gccctccgga acaggcggct cctccgcaag     2400

gtgatcaaag cagcagctct ggaggaacat aatgctgcca tgaaagatca gttgaagtta     2460

caagagaagg acatccagat gtggaaggtt agtctgcaga aagaacaagc tagatacaat     2520

cagctccagg agcagcgtga cactatggta accaagctcc acagccagat cagacagctg     2580

cagcatgacc gagaggaatt ctacaaccag agccaggaat tacagacgaa gctggaggac     2640

tgcaggaaca tgattgcgga gctgcggata gaactgaaga aggccaacaa caaggtgtgt     2700

cacactgagc tgctgctcag tcaggtttcc caaaagctct caaacagtga gtcggtccag     2760

cagcagatgg agttcttgaa caggcagctg ttggttcttg gggaggtcaa cgagctctat     2820

ttggaacaac tgcagaacaa gcactcagat accacaaagg aagtagaaat gatgaaagcc     2880

gcctatcgga aagagctaga aaaaaacaga agccatgttc tccagcagac tcagaggctt     2940

gatacctccc aaaaacggat tttggaactg gaatctcacc tggccaagaa agaccacctt     3000

cttttggaac agaagaaata tctagaggat gtcaaactcc aggcaagagg acagctgcag     3060

gccgcagaga gcaggtatga ggctcagaaa aggataaccc aggtgtttga attggagatc     3120

ttagatttat atggcaggtt ggagaaagat ggcctcctga aaaaacttga agaagaaaaa     3180

gcagaagcag ctgaagcagc agaagaaagg cttgactgtt gtaatgacgg gtgctcagat     3240

tccatggtag ggcacaatga agaggcatct ggccacaacg gtgagaccaa gacccccagg     3300

cccagcagcg cccggggcag tagtggaagc agaggtggtg gaggcagcag cagcagcagc     3360

agcgagcttt ctaccccaga gaaaccccca caccagaggg caggcccatt cagcagtcgg     3420

tgggagacga ctatgggaga agcgtctgcc agcatcccca ccactgtggg ctcacttccc     3480

agttcaaaaa gcttcctggg tatgaaggct cgagagttat ttcgtaataa gagcgagagc     3540

cagtgtgatg aggacggcat gaccagtagc ctttctgaga gcctaaagac agaactgggc     3600

aaagacttgg gtgtggaagc caagattccc ctgaacctag atggccctca cccgtctccc     3660

ccgaccccgg acagtgttgg acagctacat atcatggact acaatgagac tcatcatgaa     3720

cacagctaag gaatgatggt caatcagtgt taacttgcat attgttggca cagaacagga     3780

ggtgtgaatg cacgtttcaa agctttcctg tttccagggt ctgagtgcaa gttcatgtgt     3840

ggaaatggga cggaggtcct ttggacagct gactgaatgc agaacggttt ttggatctgg     3900

cattgaaatg cctcttgacc ttcccctcca cccgccctaa ccccctctca tttacctcgc     3960

agtgtgttct aatccaaggg ccagttggtg ttcctcagta gctttacttt cttcctttcc     4020

cccccaaatg gttgcgtcct ttgaacctgt gcaatatgag gccaaattta atctttgagt     4080

ctaacacacc actttctgct ttcccgaagt tcagataact gggttggctc tcaattagac     4140

caggtagttt gttgcattgc aggtaagtct ggttttgtcc cttccaggag gacatagcct     4200

gcaaagctgg ttgtctttac atgaaagcgt ttacatgaga ctttccgact gcttttttga     4260

ttctgaagtt cagcatctaa agcagcaggt ctagaagaac aacggtttat tcatacttgc     4320

attcttttgg cagttctgat aagcttccta gaaagttctg tgtaaacaga agcctgtttc     4380

agaaatctgg agctggcact gtggagacca cacacccttt gggaaagctc ttgtctcttc     4440

ttcccccact acctcttatt tatttggtgt ttgcttgaat gctggtacta ttgtgaccac     4500

aggctggtgt gtaggtggta aaacctgttc tccataggag ggaaggagca gtcactggga     4560

gaggttaccc gagaagcact tgagcatgag gaactgcacc tttaggccat ctcagcttgc     4620

tgggcctttt gttaaaccct tctgtctact ggcctccctt tgtgtgcata cgcctcttgt     4680

tcatgtcagc ttatatgtga cactgcagca gaaaggctct gaaggtccaa agagtttctg     4740

caaagtgtat gtgaccatca tttcccaggc cattagggtt gcctcactgt agcaggttct     4800

aggctaccag aagaggggca gctttttcat accaattcca actttcaggg gctgactctc     4860

cagggagctg atgtcatcac actctccatg ttagtaatgg cagagcagtc taaacagagt     4920

ccgggagaat gctggcaaag gctggctgtg tatacccact aggctgcccc acgtgctccc     4980

gagagatgac actagtcaga aaattggcag tggcagagaa tccaaactca acaagtgctc     5040

ctgaaagaaa cgctagaagc ctaagaactg tggtctggtg ttccagctga ggcaggggga     5100

tttggtagga aggagccagt gaacttggct ttcctgtttc tatctttcat taaaaagaat     5160

agaaggattc agtcataaag aggtaaaaaa ctgtcacggt acgaaatctt agtgcccacg     5220

gaggcctcga gcagagagaa tgaaagtctt tttttttttt tttttttttt agcatggcaa     5280

taaatattct agcatcccta actaaagggg actagacagt tagagactct gtcaccctag     5340

ctataccagc agaaaacctg ttcaggcagg ctttctgggt gtgactgatt cccagcctgt     5400

ggcagggcgt ggtcccaact actcagccta gcacaggctg gcagttggta ctgaattgtc     5460

agatgtggag tattagtgac accacacatt taattcagct ttgtccaaag gaaagcttaa     5520

aacccaatac agtctagttt cctggttccg ttttagaaaa ggaaaacgtg aacaaactta     5580

gaaagggaag gaaatcccat cagtgaatcc tgaaactggt tttaagtgct ttccttctcc     5640

tcatgcccaa gagatctgtg ccatagaaca agataccagg cacttaaagc cttttcctga     5700

attggaaagg aaaagaggcc caagtgcaaa agaaaaaaca ttttagaaac ggacagctta     5760

taaaaataaa gggaagaaag gaggcagcat ggagagaggc ctgtgctaga agctccatgg     5820

acgtgtctgc acagggtcct cagctcatcc atgcggcctg ggtgtccttt tactcagctt     5880

tataacaaat gtggctccaa gctcaggtgc ctttgagttc taggaggctg tgggttttat     5940

tcaactacgg ttgggagaat gagacctgga gtcatgttga aggtgcccaa cctaaaaatg     6000

taggctttca tgttgcaaag aactccagag tcagtagtta ggtttggttt ggttttggac     6060

atgataaacc tgccaagagt caacaggtca cttgatcatg ctgcagtggg tagttctaag     6120

gatggaaagg tgacagtatt actctcgaga ggcaattcag tcctgggcaa aggtattagt     6180

acaataagcg ttaagggcag agtctacctt gaaaccaatt aagcagcttg gtattcataa     6240

atattgggat tggatggcct ccatccagaa atcactatgg gtgagcatac ctgtctcagc     6300

tgtttggcca atgtgcataa cctactcgga tccccacctg acactaacca gagtcagcac     6360

aggccccgag gagcccgaag tctgctgctg tgcagcatgg aattccttta aaaaggtgca     6420

ctacagtttt agcggggagg gggataggaa gacgcagagc aaatgagctc cggagtccct     6480

gcaggtgaat aaacacacag atctgcatct gatagaactt tgatggattt tcaaaaagcc     6540

gttgacaagg ctctgctata cagtctataa aaattgttat tatgggattg gaagaaacac     6600

gtggtcatga atagaaaaaa aacaaaccca aaggtaggaa ggtcaaggtc atttcttaga     6660

tggagaagtt gtgaaagatg tccttggaga tgagttttag gaccagcatt actaaggcag     6720

gtgggcagac agtgacctct ctaggtgtgt ccacagagtt tttcaggaga gaaaactgcc     6780

tgacctttgg gactaagctg cggaatcttc ttactaagct tgaagagtgg agaggcgaga     6840

ggtgagctac tttgtgagcc aaagcttatg tgacatggtt ggggaaacag tccaaactgt     6900

tctgagaagg tgaactgtta cgacccagga caattagaaa aattcaccca ccatgccgca     6960

cattactggg taaaagcagg gcagcaggga acaaaactcc agactcttgg gccgtcccca     7020

tttgcaacag cacacatagt ttctggtata tttgttggga aagataaaac tctagcagtt     7080

gttgagggga ggatgtataa aatggtcatg gggatgaaag gatctctgag accacagagg     7140

ctcagactca ctgttaagaa tagaaaactg ggtatgcgtt tcatgtagcc agcagaactg     7200

aagtgtgctg tgacaagcca atgtgaattt ctaccaaata gtagagcata ccacttgaag     7260

aaggaaagaa ccgaagagca aacaaaagtt ctgcgtaatg agactcacct tttctcgctg     7320

aaagcactaa gaggtgggag gaggcctgca caggctggag gagggtttgg gcagagcgaa     7380

gacccggcca ggaccttggt gagatggggt gccgcccacc tcctgcggat actcttggag     7440

agttgttccc ccagggggct ctgccccacc tggagaagga agctgcctgg tgtggagtga     7500

ctcaaatcag tatacctatc tgctgcacct tcactctcca gggtacatgc tttaaaaccg     7560

acccgcaaca agtattggaa aaatgtatcc agtctgaaga tgtttgtgta tctgtttaca     7620

tccagagttc tgtgacacat gccccccaga ttgctgcaaa gatcccaagg cattgattgc     7680

acttgattaa gcttttgtct gtaggtgaaa gaacaagttt aggtcgagga ctggccccta     7740

ggctgctgct gtgacccttg tcccatgtgg cttgtttgcc tgtccgggac tcttcgatgt     7800

gcccagggga gcgtgttcct gtctcttcca tgccgtcctg cagtccttat ctgctcgcct     7860

gagggaagag tagctgtagc tacaagggaa gcctgcctgg aagagccgag cacctgtgcc     7920

catggcttct ggtcatgaaa cgagttaatg atggcagagg agcttcctcc ccacttcgca     7980

gcgccacatt atccatcctc tgagataagt aggctggttt aaccattgga atggaccttt     8040

cagtggaaac cctgagagtc tgagaacccc cagaccaacc cttccctccc tttccccacc     8100

tcttacagtg tttggacagg agggtatggt gctgctctgt gtagcaagta ctttggctta     8160

tgaaagaggc agccacgcat tttgcactag gaagaatcag taatcacttt tcagaagact     8220

tctatggacc acaaatatat tacggaggaa cagattttgc taagacataa tctagtttta     8280

taactcaatc atgaatgaac catgtgtggc aaacttgcag tttaaagggg tcccatcagt     8340

gaaagaaact gatttttttt aacggactgc ttttagttaa attgaagaaa gtcagctctt     8400

gtcaaaaggt ctaaactttc ccgcctcaat cctaaaagca tgtcaacaat ccacatcaga     8460

tgccataaat atgaactgca ggataaaatg gtacaatctt agtgaatggg aattggaatc     8520

aaaagagttt gctgtccttc ttagaatgtt ctaaaatgtc aaggcagttg cttgtgttta     8580

actgtgaaca aataaaaatt tattgttttg cactacaaaa aaaaaa                    8626


<210>  6
<211>  1164
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  6

Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210>  7
<211>  12444
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  7
aatctctagc tcgctcgcgc tccctctccc cgggccgtgg aaaggatccc acttccggtg       60

gggtgtcatg gcggcgtctc ggactgtgat ggctgtgggg agacggcgct agtggggaga      120

gcgaccaaga ggccccctcc cctccccggg tccccttccc ctatccccct ccccccagcc      180

tccttgccaa cgcccccttt ccctctcccc ctcccgctcg gcgctgaccc cccatcccca      240

cccccgtggg aacactggga gcctgcactc cacagaccct ctccttgcct cttccctcac      300

ctcagcctcc gctccccgcc ctcttcccgg cccagggcgc cggcccaccc ttccctccgc      360

cgccccccgg ccgcggggag gacatggccg cgcacaggcc ggtggaatgg gtccaggccg      420

tggtcagccg cttcgacgag cagcttccaa taaaaacagg acagcagaac acacatacca      480

aagtcagtac tgagcacaac aaggaatgtc taatcaatat ttccaaatac aagttttctt      540

tggttataag cggcctcact actattttaa agaatgttaa caatatgaga atatttggag      600

aagctgctga aaaaaattta tatctctctc agttgattat attggataca ctggaaaaat      660

gtcttgctgg gcaaccaaag gacacaatga gattagatga aacgatgctg gtcaaacagt      720

tgctgccaga aatctgccat tttcttcaca cctgtcgtga aggaaaccag catgcagctg      780

aacttcggaa ttctgcctct ggggttttat tttctctcag ctgcaacaac ttcaatgcag      840

tctttagtcg catttctacc aggttacagg aattaactgt ttgttcagaa gacaatgttg      900

atgttcatga tatagaattg ttacagtata tcaatgtgga ttgtgcaaaa ttaaaacgac      960

tcctgaagga aacagcattt aaatttaaag ccctaaagaa ggttgcgcag ttagcagtta     1020

taaatagcct ggaaaaggca ttttggaact gggtagaaaa ttatccagat gaatttacaa     1080

aactgtacca gatcccacag actgatatgg ctgaatgtgc agaaaagcta tttgacttgg     1140

tggatggttt tgctgaaagc accaaacgta aagcagcagt ttggccacta caaatcattc     1200

tccttatctt gtgtccagaa ataatccagg atatatccaa agacgtggtt gatgaaaaca     1260

acatgaataa gaagttattt ctggacagtc tacgaaaagc tcttgctggc catggaggaa     1320

gtaggcagct gacagaaagt gctgcaattg cctgtgtcaa actgtgtaaa gcaagtactt     1380

acatcaattg ggaagataac tctgtcattt tcctacttgt tcagtccatg gtggttgatc     1440

ttaagaacct gctttttaat ccaagtaagc cattctcaag aggcagtcag cctgcagatg     1500

tggatctaat gattgactgc cttgtttctt gctttcgtat aagccctcac aacaaccaac     1560

actttaagat ctgcctggct cagaattcac cttctacatt tcactatgtg ctggtaaatt     1620

cactccatcg aatcatcacc aattccgcat tggattggtg gcctaagatt gatgctgtgt     1680

attgtcactc ggttgaactt cgaaatatgt ttggtgaaac acttcataaa gcagtgcaag     1740

gttgtggagc acacccagca atacgaatgg caccgagtct tacatttaaa gaaaaagtaa     1800

caagccttaa atttaaagaa aaacctacag acctggagac aagaagctat aagtatcttc     1860

tcttgtccat ggtgaaacta attcatgcag atccaaagct cttgctttgt aatccaagaa     1920

aacaggggcc cgaaacccaa ggcagtacag cagaattaat tacagggctc gtccaactgg     1980

tccctcagtc acacatgcca gagattgctc aggaagcaat ggaggctctg ctggttcttc     2040

atcagttaga tagcattgat ttgtggaatc ctgatgctcc tgtagaaaca ttttgggaga     2100

ttagctcaca aatgcttttt tacatctgca agaaattaac tagtcatcaa atgcttagta     2160

gcacagaaat tctcaagtgg ttgcgggaaa tattgatctg caggaataaa tttcttctta     2220

aaaataagca ggcagataga agttcctgtc actttctcct tttttacggg gtaggatgtg     2280

atattccttc tagtggaaat accagtcaaa tgtccatgga tcatgaagaa ttactacgta     2340

ctcctggagc ctctctccgg aagggaaaag ggaactcctc tatggatagt gcagcaggat     2400

gcagcggaac ccccccgatt tgccgacaag cccagaccaa actagaagtg gccctgtaca     2460

tgtttctgtg gaaccctgac actgaagctg ttctggttgc catgtcctgt ttccgccacc     2520

tctgtgagga agcagatatc cggtgtgggg tggatgaagt gtcagtgcat aacctcttgc     2580

ccaactataa cacattcatg gagtttgcct ctgtcagcaa tatgatgtca acaggaagag     2640

cagcacttca gaaaagagtg atggcactgc tgaggcgcat tgagcatccc actgcaggaa     2700

acactgaggc ttgggaagat acacatgcaa aatgggaaca agcaacaaag ctaatcctta     2760

actatccaaa agccaaaatg gaagatggcc aggctgctga aagccttcac aagaccattg     2820

ttaagaggcg aatgtcccat gtgagtggag gaggatccat agatttgtct gacacagact     2880

ccctacagga atggatcaac atgactggct tcctttgtgc ccttggggga gtgtgcctcc     2940

agcagagaag caattctggc ctggcaacct atagcccacc catgggtcca gtcagtgaac     3000

gtaagggttc tatgatttca gtgatgtctt cagagggaaa cgcagataca cctgtcagca     3060

aatttatgga tcggctgttg tccttaatgg tgtgtaacca tgagaaagtg ggacttcaaa     3120

tacggaccaa tgttaaggat ctggtgggtc tagaattgag tcctgctctg tatccaatgc     3180

tatttaacaa attgaagaat accatcagca agttttttga ctcccaagga caggttttat     3240

tgactgatac caatactcaa tttgtagaac aaaccatagc tataatgaag aacttgctag     3300

ataatcatac tgaaggcagc tctgaacatc tagggcaagc tagcattgaa acaatgatgt     3360

taaatctggt caggtatgtt cgtgtgcttg ggaatatggt ccatgcaatt caaataaaaa     3420

cgaaactgtg tcaattagtt gaagtaatga tggcaaggag agatgacctc tcattttgcc     3480

aagagatgaa atttaggaat aagatggtag aatacctgac agactgggtt atgggaacat     3540

caaaccaagc agcagatgat gatgtaaaat gtcttacaag agatttggac caggcaagca     3600

tggaagcagt agtttcactt ctagctggtc tccctctgca gcctgaagaa ggagatggtg     3660

tggaattgat ggaagccaaa tcacagttat ttcttaaata cttcacatta tttatgaacc     3720

ttttgaatga ctgcagtgaa gttgaagatg aaagtgcgca aacaggtggc aggaaacgtg     3780

gcatgtctcg gaggctggca tcactgaggc actgtacggt ccttgcaatg tcaaacttac     3840

tcaatgccaa cgtagacagt ggtctcatgc actccatagg cttaggttac cacaaggatc     3900

tccagacaag agctacattt atggaagttc tgacaaaaat ccttcaacaa ggcacagaat     3960

ttgacacact tgcagaaaca gtattggctg atcggtttga gagattggtg gaactggtca     4020

caatgatggg tgatcaagga gaactcccta tagcgatggc tctggccaat gtggttcctt     4080

gttctcagtg ggatgaacta gctcgagttc tggttactct gtttgattct cggcatttac     4140

tctaccaact gctctggaac atgttttcta aagaagtaga attggcagac tccatgcaga     4200

ctctcttccg aggcaacagc ttggccagta aaataatgac attctgtttc aaggtatatg     4260

gtgctaccta tctacaaaaa ctcctggatc ctttattacg aattgtgatc acatcctctg     4320

attggcaaca tgttagcttt gaagtggatc ctaccaggtt agaaccatca gagagccttg     4380

aggaaaacca gcggaacctc cttcagatga ctgaaaagtt cttccatgcc atcatcagtt     4440

cctcctcaga attcccccct caacttcgaa gtgtgtgcca ctgtttatac caggcaactt     4500

gccactccct actgaataaa gctacagtaa aagaaaaaaa ggaaaacaaa aaatcagtgg     4560

ttagccagcg tttccctcag aacagcatcg gtgcagtagg aagtgccatg ttcctcagat     4620

ttatcaatcc tgccattgtc tcaccgtatg aagcagggat tttagataaa aagccaccac     4680

ctagaatcga aaggggcttg aagttaatgt caaagatact tcagagtatt gccaatcatg     4740

ttctcttcac aaaagaagaa catatgcggc ctttcaatga ttttgtgaaa agcaactttg     4800

atgcagcacg caggtttttc cttgatatag catctgattg tcctacaagt gatgcagtaa     4860

atcatagtct ttccttcata agtgacggca atgtgcttgc tttacatcgt ctactctgga     4920

acaatcagga gaaaattggg cagtatcttt ccagcaacag ggatcataaa gctgttggaa     4980

gacgaccttt tgataagatg gcaacacttc ttgcatacct gggtcctcca gagcacaaac     5040

ctgtggcaga tacacactgg tccagcctta accttaccag ttcaaagttt gaggaattta     5100

tgactaggca tcaggtacat gaaaaagaag aattcaaggc tttgaaaacg ttaagtattt     5160

tctaccaagc tgggacttcc aaagctggga atcctatttt ttattatgtt gcacggaggt     5220

tcaaaactgg tcaaatcaat ggtgatttgc tgatatacca tgtcttactg actttaaagc     5280

catattatgc aaagccatat gaaattgtag tggaccttac ccataccggg cctagcaatc     5340

gctttaaaac agactttctc tctaagtggt ttgttgtttt tcctggcttt gcttacgaca     5400

acgtctccgc agtctatatc tataactgta actcctgggt cagggagtac accaagtatc     5460

atgagcggct gctgactggc ctcaaaggta gcaaaaggct tgttttcata gactgtcctg     5520

ggaaactggc tgagcacata gagcatgaac aacagaaact acctgctgcc accttggctt     5580

tagaagagga cctgaaggta ttccacaatg ctctcaagct agctcacaaa gacaccaaag     5640

tttctattaa agttggttct actgctgtcc aagtaacttc agcagagcga acaaaagtcc     5700

tagggcaatc agtctttcta aatgacattt attatgcttc ggaaattgaa gaaatctgcc     5760

tagtagatga gaaccagttc accttaacca ttgcaaacca gggcacgccg ctcaccttca     5820

tgcaccagga gtgtgaagcc attgtccagt ctatcattca tatccggacc cgctgggaac     5880

tgtcacagcc cgactctatc ccccaacaca ccaagattcg gccaaaagat gtccctggga     5940

cactgctcaa tatcgcatta cttaatttag gcagttctga cccgagttta cggtcagctg     6000

cctataatct tctgtgtgcc ttaacttgta cctttaattt aaaaatcgag ggccagttac     6060

tagagacatc aggtttatgt atccctgcca acaacaccct ctttattgtc tctattagta     6120

agacactggc agccaatgag ccacacctca cgttagaatt tttggaagag tgtatttctg     6180

gatttagcaa atctagtatt gaattgaaac acctttgttt ggaatacatg actccatggc     6240

tgtcaaatct agttcgtttt tgcaagcata atgatgatgc caaacgacaa agagttactg     6300

ctattcttga caagctgata acaatgacca tcaatgaaaa acagatgtac ccatctattc     6360

aagcaaaaat atggggaagc cttgggcaga ttacagatct gcttgatgtt gtactagaca     6420

gtttcatcaa aaccagtgca acaggtggct tgggatcaat aaaagctgag gtgatggcag     6480

atactgctgt agctttggct tctggaaatg tgaaattggt ttcaagcaag gttattggaa     6540

ggatgtgcaa aataattgac aagacatgct tatctccaac tcctacttta gaacaacatc     6600

ttatgtggga tgatattgct attttagcac gctacatgct gatgctgtcc ttcaacaatt     6660

cccttgatgt ggcagctcat cttccctacc tcttccacgt tgttactttc ttagtagcca     6720

caggtccgct ctcccttaga gcttccacac atggactggt cattaatatc attcactctc     6780

tgtgtacttg ttcacagctt cattttagtg aagagaccaa gcaagttttg agactcagtc     6840

tgacagagtt ctcattaccc aaattttact tgctgtttgg cattagcaaa gtcaagtcag     6900

ctgctgtcat tgccttccgt tccagttacc gggacaggtc attctctcct ggctcctatg     6960

agagagagac ttttgctttg acatccttgg aaacagtcac agaagctttg ttggagatca     7020

tggaggcatg catgagagat attccaacgt gcaagtggct ggaccagtgg acagaactag     7080

ctcaaagatt tgcattccaa tataatccat ccctgcaacc aagagctctt gttgtctttg     7140

ggtgtattag caaacgagtg tctcatgggc agataaagca gataatccgt attcttagca     7200

aggcacttga gagttgctta aaaggacctg acacttacaa cagtcaagtt ctgatagaag     7260

ctacagtaat agcactaacc aaattacagc cacttcttaa taaggactcg cctctgcaca     7320

aagccctctt ttgggtagct gtggctgtgc tgcagcttga tgaggtcaac ttgtattcag     7380

caggtaccgc acttcttgaa caaaacctgc atactttaga tagtctccgt atattcaatg     7440

acaagagtcc agaggaagta tttatggcaa tccggaatcc tctggagtgg cactgcaagc     7500

aaatggatca ttttgttgga ctcaatttca actctaactt taactttgca ttggttggac     7560

accttttaaa agggtacagg catccttcac ctgctattgt tgcaagaaca gtcagaattt     7620

tacatacact actaactctg gttaacaaac acagaaattg tgacaaattt gaagtgaata     7680

cacagagcgt ggcctactta gcagctttac ttacagtgtc tgaagaagtt cgaagtcgct     7740

gcagcctaaa acatagaaag tcacttcttc ttactgatat ttcaatggaa aatgttccta     7800

tggatacata tcccattcat catggtgacc cttcctatag gacactaaag gagactcagc     7860

catggtcctc tcccaaaggt tctgaaggat accttgcagc cacctatcca actgtcggcc     7920

agaccagtcc ccgagccagg aaatccatga gcctggacat ggggcaacct tctcaggcca     7980

acactaagaa gttgcttgga acaaggaaaa gttttgatca cttgatatca gacacaaagg     8040

ctcctaaaag gcaagaaatg gaatcaggga tcacaacacc ccccaaaatg aggagagtag     8100

cagaaactga ttatgaaatg gaaactcaga ggatttcctc atcacaacag cacccacatt     8160

tacgtaaagt ttcagtgtct gaatcaaatg ttctcttgga tgaagaagta cttactgatc     8220

cgaagatcca ggcgctgctt cttactgttc tagctacact ggtaaaatat accacagatg     8280

agtttgatca acgaattctt tatgaatact tagcagaggc cagtgttgtg tttcccaaag     8340

tctttcctgt tgtgcataat ttgttggact ctaagatcaa caccctgtta tcattgtgcc     8400

aagatccaaa tttgttaaat ccaatccatg gaattgtgca gagtgtggtg taccatgaag     8460

aatccccacc acaataccaa acatcttacc tgcaaagttt tggttttaat ggcttgtggc     8520

ggtttgcagg accgttttca aagcaaacac aaattccaga ctatgctgag cttattgtta     8580

agtttcttga tgccttgatt gacacgtacc tgcctggaat tgatgaagaa accagtgaag     8640

aatccctcct gactcccaca tctccttacc ctcctgcact gcagagccag cttagtatca     8700

ctgccaacct taacctttct aattccatga cctcacttgc aacttcccag cattccccag     8760

gaatcgacaa ggagaacgtt gaactctccc ctaccactgg ccactgtaac agtggacgaa     8820

ctcgccacgg atccgcaagc caagtgcaga agcaaagaag cgctggcagt ttcaaacgta     8880

atagcattaa gaagatcgtg tgaagcttgc ttgctttctt ttttaaaatc aacttaacat     8940

gggctcttca ctagtgaccc cttccctgtc cttgcccttt ccccccatgt tgtaatgctg     9000

cacttcctgt tttataatga acccatccgg tttgccatgt tgccagatga tcaactcttc     9060

gaagccttgc ctaaatttaa tgctgccttt tctttaactt tttttcttct acttttggcg     9120

tgtatctggt atatgtaagt gttcagaaca actgcaaaga aagtgggagg tcaggaaact     9180

tttaactgag aaatctcaat tgtaagagag gatgaattct tgaatactgc tactactggc     9240

cagtgatgaa agccatttgc acagagctct gccttctgtg gttttccctt cttcatccta     9300

cagagtaaag tgttagtcct atttatacat ttttcaagat acaagtttat gagagaaata     9360

gtattataac cccagtatgt ttaatctttt agctgtggac ttttttttta accgtacaaa     9420

actgaaagaa ccatagaggt caagcctcag tgacttgaca ccataaagcc acagacaagg     9480

tacttggggg ggagggcagg gaaatttcat attttatagt ggattcttaa gaaatactaa     9540

cacttgagta ttagcaataa ttacaggaaa ataagtgcga ccacatatat cttaacatta     9600

ctgaattaaa actatggctt ctaagtcctt atccaaactc agtcatccaa actagtttat     9660

ttttttctcc agttgattat cttttaattt ttaattttgc taaaggtggt ttttttgtgt     9720

tttgtttttt gtaaaccaaa actatactaa gtatagtaat tatatatata tatatatttt     9780

ttcccctccc cctcttcttt cctaactaat tctgagcagg gtaatcagtg aacaaagtgt     9840

tgaaaattgt tcccagaagg taattttcat agatgtttgc attagctcca tagcaaaatg     9900

gaatggtacg tgacatttag ggtagctgat atttttattt tgttaaataa tttccaagaa     9960

tagagtatgg tgtatattat aaatttcttt gataagatgt attttgaatg tcttttaatc    10020

ttcctcctcc tctccaaaaa aatcagaaac ctctttaaga aaacatgtag gttatatatg    10080

ctagaattgc atttaatcac tgtgaaaaga ctggtcagcc tgcattagta tgacagtagg    10140

ggggctgtta gaattgctgc tatactggtg gtatggatta tcatggcatt ggaattttca    10200

tagtaatgca gatccaattt ctttgtggta cctgcagttt acaaaataat ttgacttcag    10260

tgagcatatt ggtatctgga tgttccaatt tagaactaaa ccatatttat tacaaaaaga    10320

tattaatccc tctactccca ggttcccttt atatgttaag atataatggc tttgaggggg    10380

gaaaaaataa acctagggga gaggggagtt tcctgtagtg ctgtttcatt agaggatttc    10440

agtaaattaa attccacagc taattcaata aataatggta catttaagtg ttctgatttt    10500

aataatatat ttcacattta tccacacagt aacaatgtaa tatgttaatg taaataaaat    10560

tggttttgat actcagaaat aacaagaatt taatttttta aatttgttta cagtcctggg    10620

aaaagtaaga attatttgcc aaaataagag gaaagaaaac cttagtatta ttaatgagtt    10680

taccatagaa ttgttggaaa tactgaagac aggtgcaatt tactaaactt ttgtttttaa    10740

actattgtag aggctgcatt agaagaaaat gtttataatg acagagcaac tatgactata    10800

taaaaaagct gaaattagaa ctgtgtttag aaatagatca gtaacccagt gccaaggatg    10860

ccaagctgcc accatggtct tggctctccc acaacccagt gtttctgggg taagtttcac    10920

agtttctagg ccctggaata gcaggcagtg taagcctttg ataactttag ttcgatgttt    10980

ttcttgtttt tgtttgttgg tttggtgcat atgatagtgg gtgttatgct attttgctct    11040

tcccatcaaa ataaagaaac ttccagaggt ttactgttaa aaatactgat atttccataa    11100

acgggtttac caagggtgta gtatttcata ccgcctgaaa tgatcagcat tggcacaaat    11160

caaaattcag ccgcctttga aatgcaaaaa tacctttgac tagtaagtac atcctaggag    11220

tttgaaaact taactaaggt ttaaaattta ccttgtttaa agaacttctg acttttgagg    11280

aaaatctagc tttccaagta actaaaatgt acatgagata aacctctcac cactatgtgt    11340

cccttgagaa atgcaacact tttttagtct tcatacttgt aatctataaa agaaattctg    11400

aagtttagac caagttgccc atttctgcgt aattgacata agttctgtta aaaatattat    11460

aagtaattcg tttcggtttg tagatgtttc ccctgacttg ttaaagagga aaccaggaac    11520

tcagtcatgt ttttgtcctg gataatctac ctgttatgcc agtactccca tccgaggggc    11580

atgcccttag ttgcccagat ggagatgcag ttcagtagat ttggggcaaa gtggctacag    11640

ctctgtcttc cattcactca acacctgttc atgactgagc caggtgccca ggacacatcc    11700

taaacagtca gcttctatcc tgtgtcctag ttggggagac agagtgccag ccagcaaccc    11760

tcccaggttt gtaggtttta ggggttttca gttttgtttg ggttttttgt tttttgtttt    11820

tgtttctaca tccttccccg actcccaggc ataatgaggc atgtcttact caatgttatg    11880

caatggattt aggcaaaaat tcattcttag tgtcagccac acaatttttt ttaatgcagt    11940

atattcacct gtaaatagtt tgtgtaaaat ttgacaaaaa aagtatattt actatactgt    12000

aaatatatgt gatgatatat tgtattattt tgcttttttg taaagcagtt agttgctgca    12060

catggataac aacaaaaatt tgattattct cgtgttagta ttgttaactt ctttttgcga    12120

ctgcgttaca tcatttaaag aaaatgctgt gtattgtaaa cttaaattgt atatgataac    12180

ttactgtcct ttccatccgg gcctaaactt tggcagttcc tttgtctaca accttgttaa    12240

tactgtaaac agttgtacgc cagcaggaaa aatactgccc aacagacaaa atcgatcatt    12300

gtaggggaaa atcatagaaa tccatttcag atctttattg ttcctcaccc cattttcctc    12360

cttgtgtatg tacttccccc accccccttt ttttaagtaa aatgtaaatt caatctgctc    12420

taagaaaaaa aaaaaaaaaa aaaa                                           12444


<210>  8
<211>  2839
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  8

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210>  9
<211>  4772
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  9
gctcagttgc cgggcggggg agggcgcgtc cggtttttct caggggacgt tgaaattatt       60

tttgtaacgg gagtcgggag aggacggggc gtgccccgac gtgcgcgcgc gtcgtcctcc      120

ccggcgctcc tccacagctc gctggctccc gccgcggaaa ggcgtcatgc cgcccaaaac      180

cccccgaaaa acggccgcca ccgccgccgc tgccgccgcg gaacccccgg caccgccgcc      240

gccgccccct cctgaggagg acccagagca ggacagcggc ccggaggacc tgcctctcgt      300

caggcttgag tttgaagaaa cagaagaacc tgattttact gcattatgtc agaaattaaa      360

gataccagat catgtcagag agagagcttg gttaacttgg gagaaagttt catctgtgga      420

tggagtattg ggaggttata ttcaaaagaa aaaggaactg tggggaatct gtatctttat      480

tgcagcagtt gacctagatg agatgtcgtt cacttttact gagctacaga aaaacataga      540

aatcagtgtc cataaattct ttaacttact aaaagaaatt gataccagta ccaaagttga      600

taatgctatg tcaagactgt tgaagaagta tgatgtattg tttgcactct tcagcaaatt      660

ggaaaggaca tgtgaactta tatatttgac acaacccagc agttcgatat ctactgaaat      720

aaattctgca ttggtgctaa aagtttcttg gatcacattt ttattagcta aaggggaagt      780

attacaaatg gaagatgatc tggtgatttc atttcagtta atgctatgtg tccttgacta      840

ttttattaaa ctctcacctc ccatgttgct caaagaacca tataaaacag ctgttatacc      900

cattaatggt tcacctcgaa cacccaggcg aggtcagaac aggagtgcac ggatagcaaa      960

acaactagaa aatgatacaa gaattattga agttctctgt aaagaacatg aatgtaatat     1020

agatgaggtg aaaaatgttt atttcaaaaa ttttatacct tttatgaatt ctcttggact     1080

tgtaacatct aatggacttc cagaggttga aaatctttct aaacgatacg aagaaattta     1140

tcttaaaaat aaagatctag atgcaagatt atttttggat catgataaaa ctcttcagac     1200

tgattctata gacagttttg aaacacagag aacaccacga aaaagtaacc ttgatgaaga     1260

ggtgaatgta attcctccac acactccagt taggactgtt atgaacacta tccaacaatt     1320

aatgatgatt ttaaattcag caagtgatca accttcagaa aatctgattt cctattttaa     1380

caactgcaca gtgaatccaa aagaaagtat actgaaaaga gtgaaggata taggatacat     1440

ctttaaagag aaatttgcta aagctgtggg acagggttgt gtcgaaattg gatcacagcg     1500

atacaaactt ggagttcgct tgtattaccg agtaatggaa tccatgctta aatcagaaga     1560

agaacgatta tccattcaaa attttagcaa acttctgaat gacaacattt ttcatatgtc     1620

tttattggcg tgcgctcttg aggttgtaat ggccacatat agcagaagta catctcagaa     1680

tcttgattct ggaacagatt tgtctttccc atggattctg aatgtgctta atttaaaagc     1740

ctttgatttt tacaaagtga tcgaaagttt tatcaaagca gaaggcaact tgacaagaga     1800

aatgataaaa catttagaac gatgtgaaca tcgaatcatg gaatcccttg catggctctc     1860

agattcacct ttatttgatc ttattaaaca atcaaaggac cgagaaggac caactgatca     1920

ccttgaatct gcttgtcctc ttaatcttcc tctccagaat aatcacactg cagcagatat     1980

gtatctttct cctgtaagat ctccaaagaa aaaaggttca actacgcgtg taaattctac     2040

tgcaaatgca gagacacaag caacctcagc cttccagacc cagaagccat tgaaatctac     2100

ctctctttca ctgttttata aaaaagtgta tcggctagcc tatctccggc taaatacact     2160

ttgtgaacgc cttctgtctg agcacccaga attagaacat atcatctgga cccttttcca     2220

gcacaccctg cagaatgagt atgaactcat gagagacagg catttggacc aaattatgat     2280

gtgttccatg tatggcatat gcaaagtgaa gaatatagac cttaaattca aaatcattgt     2340

aacagcatac aaggatcttc ctcatgctgt tcaggagaca ttcaaacgtg ttttgatcaa     2400

agaagaggag tatgattcta ttatagtatt ctataactcg gtcttcatgc agagactgaa     2460

aacaaatatt ttgcagtatg cttccaccag gccccctacc ttgtcaccaa tacctcacat     2520

tcctcgaagc ccttacaagt ttcctagttc acccttacgg attcctggag ggaacatcta     2580

tatttcaccc ctgaagagtc catataaaat ttcagaaggt ctgccaacac caacaaaaat     2640

gactccaaga tcaagaatct tagtatcaat tggtgaatca ttcgggactt ctgagaagtt     2700

ccagaaaata aatcagatgg tatgtaacag cgaccgtgtg ctcaaaagaa gtgctgaagg     2760

aagcaaccct cctaaaccac tgaaaaaact acgctttgat attgaaggat cagatgaagc     2820

agatggaagt aaacatctcc caggagagtc caaatttcag cagaaactgg cagaaatgac     2880

ttctactcga acacgaatgc aaaagcagaa aatgaatgat agcatggata cctcaaacaa     2940

ggaagagaaa tgaggatctc aggaccttgg tggacactgt gtacacctct ggattcattg     3000

tctctcacag atgtgactgt ataactttcc caggttctgt ttatggccac atttaatatc     3060

ttcagctctt tttgtggata taaaatgtgc agatgcaatt gtttgggtga ttcctaagcc     3120

acttgaaatg ttagtcattg ttatttatac aagattgaaa atcttgtgta aatcctgcca     3180

tttaaaaagt tgtagcagat tgtttcctct tccaaagtaa aattgctgtg ctttatggat     3240

agtaagaatg gccctagagt gggagtcctg ataacccagg cctgtctgac tactttgcct     3300

tcttttgtag catataggtg atgtttgctc ttgtttttat taatttatat gtatattttt     3360

ttaatttaac atgaacaccc ttagaaaatg tgtcctatct atcttccaaa tgcaatttga     3420

ttgactgccc attcaccaaa attatcctga actcttctgc aaaaatggat attattagaa     3480

attagaaaaa aattactaat tttacacatt agattttatt ttactattgg aatctgatat     3540

actgtgtgct tgttttataa aattttgctt ttaattaaat aaaagctgga agcaaagtat     3600

aaccatatga tactatcata ctactgaaac agatttcata cctcagaatg taaaagaact     3660

tactgattat tttcttcatc caacttatgt ttttaaatga ggattattga tagtactctt     3720

ggtttttata ccattcagat cactgaattt ataaagtacc catctagtac ttgaaaaagt     3780

aaagtgttct gccagatctt aggtatagag gaccctaaca cagtatatcc caagtgcact     3840

ttctaatgtt tctgggtcct gaagaattaa gatacaaatt aattttactc cataaacaga     3900

ctgttaatta taggagcctt aatttttttt tcatagagat ttgtctaatt gcatctcaaa     3960

attattctgc cctccttaat ttgggaaggt ttgtgttttc tctggaatgg tacatgtctt     4020

ccatgtatct tttgaactgg caattgtcta tttatctttt atttttttaa gtcagtatgg     4080

tctaacactg gcatgttcaa agccacatta tttctagtcc aaaattacaa gtaatcaagg     4140

gtcattatgg gttaggcatt aatgtttcta tctgattttg tgcaaaagct tcaaattaaa     4200

acagctgcat tagaaaaaga ggcgcttctc ccctccccta cacctaaagg tgtatttaaa     4260

ctatcttgtg tgattaactt atttagagat gctgtaactt aaaatagggg atatttaagg     4320

tagcttcagc tagcttttag gaaaatcact ttgtctaact cagaattatt tttaaaaaga     4380

aatctggtct tgttagaaaa caaaatttta ttttgtgctc atttaagttt caaacttact     4440

attttgacag ttattttgat aacaatgaca ctagaaaact tgactccatt tcatcattgt     4500

ttctgcatga atatcataca aatcagttag tttttaggtc aagggcttac tatttctggg     4560

tcttttgcta ctaagttcac attagaatta gtgccagaat tttaggaact tcagagatcg     4620

tgtattgaga tttcttaaat aatgcttcag atattattgc tttattgctt ttttgtattg     4680

gttaaaactg tacatttaaa attgctatgt tactattttc tacaattaat agtttgtcta     4740

ttttaaaata aattagttgt taagagtctt aa                                   4772


<210>  10
<211>  928
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  10

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
        35                  40                  45              


Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
    50                  55                  60                  


Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
65                  70                  75                  80  


Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                85                  90                  95      


Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
            100                 105                 110         


Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
        115                 120                 125             


His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
    130                 135                 140                 


Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
145                 150                 155                 160 


Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                165                 170                 175     


Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
            180                 185                 190         


Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
        195                 200                 205             


Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
    210                 215                 220                 


Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
225                 230                 235                 240 


Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                245                 250                 255     


Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
            260                 265                 270         


Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
        275                 280                 285             


Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
    290                 295                 300                 


Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
305                 310                 315                 320 


Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                325                 330                 335     


Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
            340                 345                 350         


Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
        355                 360                 365             


Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
    370                 375                 380                 


Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
385                 390                 395                 400 


Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                405                 410                 415     


Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
            420                 425                 430         


Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
        435                 440                 445             


Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
    450                 455                 460                 


Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
465                 470                 475                 480 


Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                485                 490                 495     


Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
            500                 505                 510         


Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
        515                 520                 525             


Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
    530                 535                 540                 


Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
545                 550                 555                 560 


Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                565                 570                 575     


Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
            580                 585                 590         


Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
        595                 600                 605             


Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
    610                 615                 620                 


Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                645                 650                 655     


Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
            660                 665                 670         


His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
        675                 680                 685             


Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
    690                 695                 700                 


Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
705                 710                 715                 720 


Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                725                 730                 735     


Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
            740                 745                 750         


Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
        755                 760                 765             


Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
    770                 775                 780                 


Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
785                 790                 795                 800 


Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                805                 810                 815     


Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
            820                 825                 830         


Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
        835                 840                 845             


Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
    850                 855                 860                 


Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
865                 870                 875                 880 


Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                885                 890                 895     


Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
            900                 905                 910         


Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
        915                 920                 925             


<210>  11
<211>  183
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  11
gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat       60

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      120

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      180

ccg                                                                    183


<210>  12
<211>  314
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  12
gatccgacgc gccatctcta ggcccgcgcc ggccccctcg cacggacttg tgggagaagc       60

tcggctactc ccctgccccg gttaatttgc atataatatt tcctagtaac tatagaggct      120

taatgtgcga taaaagacag ataatctgtt ctttttaata ctagctacat tttacatgat      180

aggcttggat ttctataact tcgtatagca tacattatac gaagttataa acagcacaaa      240

aggaaactca ccctaactgt aaagtaattg tgtgttttga gactataagt atcccttgga      300

gaaccacctt gttg                                                        314


<210>  13
<211>  93
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  13
gtttaagagc taagctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgctttt ttt                                    93


<210>  14
<211>  82
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  14
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  15
<211>  889
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  15
tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta       60

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      120

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      180

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      240

ccgcctcccg ctcctggagc gggtttaaga gctaagctgg aaacagcata gcaagtttaa      300

ataaggctag tccgttatca acttgaaaaa gtggcaccga gtcggtgctt tttttctcga      360

gtactaggat ccattaggcg gccgcgtcga caagctttct agagaattcg atccgacgcg      420

ccatctctag gcccgcgccg gccccctcgc acggacttgt gggagaagct cggctactcc      480

cctgccccgg ttaatttgca tataatattt cctagtaact atagaggctt aatgtgcgat      540

aaaagacaga taatctgttc tttttaatac tagctacatt ttacatgata ggcttggatt      600

tctataactt cgtatagcat acattatacg aagttataaa cagcacaaaa ggaaactcac      660

cctaactgta aagtaattgt gtgttttgag actataagta tcccttggag aaccaccttg      720

ttggatattc accattatag gtgttttaga gctagaaata gcaagttaaa ataaggctag      780

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttgaattc tagacttgat      840

gctaactagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagt                  889


<210>  16
<211>  92
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (32)..(47)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  n is a, c, g, t or u

<400>  16
gtggaaagga cgaaacaccg gtttngagac gnnnnnnnnn nnnnnnncgt ctcngttggt       60

tttagagcta gaaatagcaa gttaaaataa gg                                     92


<210>  17
<211>  16
<212>  RNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  n is a, c, g, or u

<400>  17
nnnnnnnnnn nnnnnn                                                       16


<210>  18
<211>  60
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  18
taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg       60


<210>  19
<211>  60
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  19
actttttcaa gttgataacg gactagcctt attttaactt gctatttcta gctctaaaac       60


<210>  20
<211>  1880
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  20
gagacggttg taaatgagca cacaaaatac acatgctaaa atattatatt ctatgacctt       60

tataaaatca accaaaatct tctttttaat aactttagta tcaataatta gaatttttat      120

gttccttttt gcaaactttt aataaaaatg agcaaaataa aaaaacgcta gttttagtaa      180

ctcgcgttgt tttcttcacc tttaataata gctactccac cacttgttcc taagcggtca      240

gctcctgctt caatcatttt ttgagcatct tcaaatgttc taactccacc agctgcttta      300

actaaagcat tgtctttaac aactgacttc attagtttaa catcttcaaa tgttgcacct      360

gattttgaaa atcctgttga tgttttaaca aattctaatc cagcttcaac agctatttca      420

caagctttca tgatttcttc ttttgttaat aaacaatttt ccataataca tttaacaaca      480

tgtgatccag ctgctttttt tacagctttc atgtcttcta aaactaattc ataatttttg      540

tcttttaatg caccaatatt taataccata tcaatttctg ttgcaccatc tttaattgct      600

tcagaaactt cgaatgcttt tgtagctgtt gtgcatgcac ctagaggaaa acctacaaca      660

tttgttattc ctacatttgt gccttttaat aattctttac aatagcttgt tcaatatgaa      720

ttaacacaaa ctgttgcaaa atcaaattca attgcttcat cacataattg tttaatttca      780

gctttcgtag catcttgttt taataatgtg tgatctatat atttgtttag tttcattttt      840

tctcctatat attcattttt aattttaatt ctttaataat ttcgtctact ttaactttag      900

cgttttgaac agattcacca acacctataa aataaatttt tagtttaggt tcagttccac      960

ttgggcgaac agcaaatcat gacttatctt ctaaataaaa ttttagtaag tcttgtcctg     1020

gcatattata cattccatcg atgtagtctt caacattaac aactttaagt ccagcaattt     1080

gagttaaggg tgttgctctc aatgatttca ttaatggttc aatttttaat ttcttttctt     1140

ctggtttaaa attcaagttt aaagtgaaag tgtaatatgc acccatttct ttaaataaat     1200

cttctaaata gtctactaat gttttatttt gttttttata aaatcaagca gcctctgcta     1260

ttaatataga agcttgtatt ccatctttat ctctagctga gtcatcaatt acatatccat     1320

aactttcttc ataagcaaaa acaaaattta atccgttatc ttcttcttta gcaatttctc     1380

tacccattca tttaaatcca gttaaagttt ttacaatatt aactccatat ttttcatgag     1440

cgattctatc acccaaatca cttgttacaa aacttgaata tagagccgga ttttttggaa     1500

tgctatttaa gcgttttaga tttgataatt ttcaatcaat taaaattggt cctgtttgat     1560

ttccatctaa tcttacaaaa tgaccatcat gttttattgc cattccaaat ctgtcagcat     1620

ctgggtcatt cataataata atatctgcat catgtttaat accatattca agcggtattt     1680

ttcatgcagg atcaaattct ggatttggat ttacaacatt tttaaatgtt tcatcttcaa     1740

atgcatgctc ttcaacctca ataacgttat atcctgattc acgtaatatt tttggggtaa     1800

atttagttcc tgttccatta actgcgctaa aaataatttt taaatctttt ttagcttctt     1860

gctctttttt gtacgtctct                                                 1880


<210>  21
<211>  461
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  21
gtttaagagc taagctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgctttt tttctcgagt actaggatcc attaggcggc      120

cgcgtcgaca agctttctag agaattcgat ccgacgcgcc atctctaggc ccgcgccggc      180

cccctcgcac ggacttgtgg gagaagctcg gctactcccc tgccccggtt aatttgcata      240

taatatttcc tagtaactat agaggcttaa tgtgcgataa aagacagata atctgttctt      300

tttaatacta gctacatttt acatgatagg cttggatttc tataacttcg tatagcatac      360

attatacgaa gttataaaca gcacaaaagg aaactcaccc taactgtaaa gtaattgtgt      420

gttttgagac tataagtatc ccttggagaa ccaccttgtt g                          461


<210>  22
<211>  889
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  22
tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta       60

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      120

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      180

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      240

ccgcctcccg ctcctggagc gggtttaaga gctaagctgg aaacagcata gcaagtttaa      300

ataaggctag tccgttatca acttgaaaaa gtggcaccga gtcggtgctt tttttctcga      360

gtactaggat ccattaggcg gccgcgtcga caagctttct agagaattcg atccgacgcg      420

ccatctctag gcccgcgccg gccccctcgc acggacttgt gggagaagct cggctactcc      480

cctgccccgg ttaatttgca tataatattt cctagtaact atagaggctt aatgtgcgat      540

aaaagacaga taatctgttc tttttaatac tagctacatt ttacatgata ggcttggatt      600

tctataactt cgtatagcat acattatacg aagttataaa cagcacaaaa ggaaactcac      660

cctaactgta aagtaattgt gtgttttgag actataagta tcccttggag aaccaccttg      720

ttggatattc accattatag gtgttttaga gctagaaata gcaagttaaa ataaggctag      780

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttgaattc tagacttgat      840

gctaactagg tcttgaaagg agtgggaatt ggctccggtg cccgtcagt                  889


<210>  23
<211>  80
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  23
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatcttt       60

gtggaaagga cgaaacaccg                                                   80


<210>  24
<211>  70
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  24
tctactattc tttcccctgc actgtacccg gactagcctt attttaactt gctatttcta       60

gctctaaaac                                                              70


<210>  25
<211>  94
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER


<220>
<221>  misc_feature
<222>  (59)..(66)
<223>  n is a, c, g, t or u

<400>  25
caagcagaag acggcatacg agatgtgact ggagttcaga cgtgtgctct tccgatctnn       60

nnnnnntcta ctattctttc ccctgcactg tacc                                   94


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  26
gagatctaca ctctttccct acacgacgct cttccgatct                             40


<210>  27
<211>  53
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  27
tgcactgtac ccggactagc cttattttaa cttgctattt ctagctctaa aac              53


<210>  28
<211>  37
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  28
gctagtccgg gtacagtgca ggggaaagaa tagtaga                                37


<210>  29
<211>  97
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  29
atcttgtgga aaggacgaaa caccggttta gagacgagcc tctatactta ctaaacgtga       60

tcgtctcaac cggtttaaga gctatgctgg aaacagc                                97


<210>  30
<211>  2755
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  30
ccgggccgcg cttcctctcg ccaggcctgc gagcttcctc ccagcggagc cctgggcgag       60

ccgaggttgg ccgccgccgc cgccgagccc gctgccgccc tcccgctcct gccccacccg      120

cgccttgccc gggggcttct gccggggtgg ggtccgagcc gggcgaccgc ccggctgcgc      180

cgccgtcggg gccgtaaccc ggcccgccgt ccctcccgcc ccagccagcc tctggccgcc      240

ggagcccgcg gggcgtggag cgcgaggagc cccgcggccc cgatcgagcg tccggggcgg      300

cccccggcag ccagcgcgac gttccaaaat cgaacctcag tggcggcgct cggaagcgga      360

actctgccgg ggccgcgccg gctacattgt ttcctccccc cgactccctc ccgccccctt      420

cccccgcctt tcttccctcc gcgacccggg ccgtgcgtcc gtccccctgc ctctgcctgg      480

cggtccctcc tcccctctcc ttgcacccat acctctttgt accgcacccc ctggggaccc      540

ctgcgcccct cccctccccc ctgaccgcat ggaccgtccc gcaggccgct gatgccgccc      600

gcggcgaggt ggcccggacc gcagtgcccc aagagagctc taatggtacc aagtgacagg      660

ttggctttac tgtgactcgg ggacgccaga gctcctgaga agatgtcagc aatacaggcc      720

gcctggccat ccggtacaga atgtattgcc aagtacaact tccacggcac tgccgagcag      780

gacctgccct tctgcaaagg agacgtgctc accattgtgg ccgtcaccaa ggaccccaac      840

tggtacaaag ccaaaaacaa ggtgggccgt gagggcatca tcccagccaa ctacgtccag      900

aagcgggagg gcgtgaaggc gggtaccaaa ctcagcctca tgccttggtt ccacggcaag      960

atcacacggg agcaggctga gcggcttctg tacccgccgg agacaggcct gttcctggtg     1020

cgggagagca ccaactaccc cggagactac acgctgtgcg tgagctgcga cggcaaggtg     1080

gagcactacc gcatcatgta ccatgccagc aagctcagca tcgacgagga ggtgtacttt     1140

gagaacctca tgcagctggt ggagcactac acctcagacg cagatggact ctgtacgcgc     1200

ctcattaaac caaaggtcat ggagggcaca gtggcggccc aggatgagtt ctaccgcagc     1260

ggctgggccc tgaacatgaa ggagctgaag ctgctgcaga ccatcgggaa gggggagttc     1320

ggagacgtga tgctgggcga ttaccgaggg aacaaagtcg ccgtcaagtg cattaagaac     1380

gacgccactg cccaggcctt cctggctgaa gcctcagtca tgacgcaact gcggcatagc     1440

aacctggtgc agctcctggg cgtgatcgtg gaggagaagg gcgggctcta catcgtcact     1500

gagtacatgg ccaaggggag ccttgtggac tacctgcggt ctaggggtcg gtcagtgctg     1560

ggcggagact gtctcctcaa gttctcgcta gatgtctgcg aggccatgga atacctggag     1620

ggcaacaatt tcgtgcatcg agacctggct gcccgcaatg tgctggtgtc tgaggacaac     1680

gtggccaagg tcagcgactt tggtctcacc aaggaggcgt ccagcaccca ggacacgggc     1740

aagctgccag tcaagtggac agcccctgag gccctgagag agaagaaatt ctccactaag     1800

tctgacgtgt ggagtttcgg aatccttctc tgggaaatct actcctttgg gcgagtgcct     1860

tatccaagaa ttcccctgaa ggacgtcgtc cctcgggtgg agaagggcta caagatggat     1920

gcccccgacg gctgcccgcc cgcagtctat gaagtcatga agaactgctg gcacctggac     1980

gccgccatgc ggccctcctt cctacagctc cgagagcagc ttgagcacat caaaacccac     2040

gagctgcacc tgtgacggct ggcctccgcc tgggtcatgg gcctgtgggg actgaacctg     2100

gaagatcatg gacctggtgc ccctgctcac tgggcccgag cctgaactga gccccagcgg     2160

gctggcgggc ctttttcctg cgtcccagcc tgcacccctc cggccccgtc tctcttggac     2220

ccacctgtgg ggcctgggga gcccactgag gggccaggga ggaaggaggc cacggagcgg     2280

gaggcagcgc cccaccacgt cgggcttccc tggcctcccg ccactcgcct tcttagagtt     2340

ttattccttt ccttttttga gatttttttt ccgtgtgttt attttttatt atttttcaag     2400

ataaggagaa agaaagtacc cagcaaatgg gcattttaca agaagtacga atcttatttt     2460

tcctgtcctg cccgtgaggg tgggggggac cgggcccctc tctagggacc cctcgcccca     2520

gcctcattcc ccattctgtg tcccatgtcc cgtgtctcct cggtcgcccc gtgtttgcgc     2580

ttgaccatgt tgcactgttt gcatgcgccc gaggcagacg tctgtcaggg gcttggattt     2640

cgtgtgccgc tgccacccgc ccacccgcct tgtgagatgg aattgtaata aaccacgcca     2700

tgaggacacc gccgcccgcc tcggcgcttc ctccaccgag aaaaaaaaaa aaaaa          2755


<210>  31
<211>  450
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  31

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Gly Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  32
<211>  5619
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  32
gacgtgcgcg ggcgtgcgcg gtgacggccc gcgtctctgt tactcagccg agcggccgag       60

gccggacgac gcggcttgga ttgcggagcc gcgagcagcg ctgggtaacg gccgcggcga      120

ccaccccgga cggcccctgt ccccgctggc gggcttccct gtcgccgttc gctgcgctgc      180

cggcttcttg gtgaattttt ggatgaagcc attaaattaa ttgcttgcca tcatgagcag      240

aagcaagcgt gacaacaatt tttatagtgt agagattgga gattctacat tcacagtcct      300

gaaacgatat cagaatttaa aacctatagg ctcaggagct caaggaatag tatgcgcagc      360

ttatgatgcc attcttgaaa gaaatgttgc aatcaagaag ctaagccgac catttcagaa      420

tcagactcat gccaagcggg cctacagaga gctagttctt atgaaatgtg ttaatcacaa      480

aaatataatt ggccttttga atgttttcac accacagaaa tccctagaag aatttcaaga      540

tgtttacata gtcatggagc tcatggatgc aaatctttgc caagtgattc agatggagct      600

agatcatgaa agaatgtcct accttctcta tcagatgctg tgtggaatca agcaccttca      660

ttctgctgga attattcatc gggacttaaa gcccagtaat atagtagtaa aatctgattg      720

cactttgaag attcttgact tcggtctggc caggactgca ggaacgagtt ttatgatgac      780

gccttatgta gtgactcgct actacagagc acccgaggtc atccttggca tgggctacaa      840

ggaaaacgct gactcagaac acaacaaact taaagccagt caggcaaggg atttgttatc      900

caaaatgctg gtaatagatg catctaaaag gatctctgta gatgaagctc tccaacaccc      960

gtacatcaat gtctggtatg atccttctga agcagaagct ccaccaccaa agatccctga     1020

caagcagtta gatgaaaggg aacacacaat agaagagtgg aaagaattga tatataagga     1080

agttatggac ttggaggaga gaaccaagaa tggagttata cgggggcagc cctctccttt     1140

aggtgcagca gtgatcaatg gctctcagca tccatcatca tcgtcgtctg tcaatgatgt     1200

gtcttcaatg tcaacagatc cgactttggc ctctgataca gacagcagtc tagaagcagc     1260

agctgggcct ctgggctgct gtagatgact acttgggcca tcggggggtg ggagggatgg     1320

ggagtcggtt agtcattgat agaactactt tgaaaacaat tcagtggtct tatttttggg     1380

tgatttttca aaaaatgtag aattcatttt gtagtaaagt agtttatttt ttttaatttc     1440

aagtgatgta atttaaaacc taagttgtgt ttcaaaacag caacaaaact gtattgtatt     1500

ttttttgctg taattaactg tataatgtaa acctaattat tttatcatgg tttaaatttt     1560

ttgcatattt gctttatctt atgctgctga tttttttaac tgaatttgta agattttgtt     1620

tatcaaagca actattatgt ggtgacttgc ctatatcatg aattatttaa gatttttata     1680

gtttttttta attagaattt atttcagatg ttttgttcat gatactatcc ttcagggtta     1740

tgtgcttatc aatgaaataa ccccagagga gtgagggaaa ataacttgta gccagttata     1800

ttcaggaata actactgtaa atgatgaacg tgttaggaga cctccaatat ttgctacttg     1860

ccaatcctaa tttagttaca agaattggta ggcaatccta cttaattttg gcaaaagccc     1920

cgtcatctaa atggcagaat aactcagagc atgtctttga agatgctggg cgtctaccac     1980

caccttatgt ccccacccta cccaacaaaa ataagtaaaa agaatatggt gtattctaca     2040

aatttgtggc atgctcaaag tttatgatca cataaaggca agaggatact tcatgaataa     2100

tacatttcaa tgcaaataaa cagatggttc acttctacta gctatgagcc tgtttttgta     2160

tacactgagt taatctactc aggctgtagg tcccagcaat gttctagagt ctggtctttc     2220

cctttcctgc agcttcgggt ccttggacct ttcctgtttc ctattacttg gagtgtctgt     2280

cagttgagca ccagttgttc tggtgtttca tttgattcta cttgtagcat aatcatttat     2340

acgagctatt gggaggttcc aaaccctacc tagatttgtg taggtgatgt atcaaatgag     2400

caatataccg ttcatctgaa aatagtagca cacagccata tataggatat cattttctaa     2460

ggactgtttc ttcacattga gcagagcagg cataaatggt ggttatttag tctaagtctt     2520

ttattttttt atacctgatt ttcaacataa cacgcaatgt ggatgtcgag tagtgttaag     2580

aatggtgctg ctcctgacaa gtgtatgtta actgtttaca ttttctatct gtagaattat     2640

ttctctatta ctgaactttt cctaagtaaa atgtctttga agtctcgtta tttctgaaat     2700

acgttgtctg taatagaccc aggcaccttt taaattatct ctggaacaag agggatttca     2760

tgtaatgaac taggaaatgc atactcacat aagcaacaag gttctaggca gaaagcccct     2820

tggaatttgt gaccaacagg agcaagaaca ggtgcggctc aacatgcaat gtctgaaaat     2880

ttgcttggca ttttattcat atatttagtg caaaattatt tttgagtgag atattttaca     2940

tcactgttaa tgtgcaatat ttaagattaa aatacattag cttttttata tactttgaag     3000

tagcaagttt gttttcgatg gcttagagtc atgatttcca gcttcccagc ctttttatca     3060

gtcccttttc taatacaaca aggtgcatta atttgattag gcaaattaga gttctaagac     3120

acttcttgaa ttgtagacag aaaatattgg attcacaatt tcagcagaaa tttgagaatg     3180

agtgtgttta tattaatttc acaattagct gtattttctg tagcatagat tatgtcactg     3240

ttgcactttc acagcagaca tgctttcaga aggttctcat attttatgtt tgattgctga     3300

taagccatct ctattgatac agattttggt taagtaagga aaaccaggtg tgtgtctgta     3360

tcatttattg taaatgccag ctgccacttg ccaaccatca tgttcagttc aattcaaaga     3420

aaacaaactc tcattactta gtgtaaacta aaatacttaa caaattatat cctaaaaaca     3480

aggtctcttt gttaaatgtt gcatgcccta ggttttaaat tactacatcc aaatacagtt     3540

ttcgtcttaa atttgttaag ctaaatatat gttggttctt tttattttgg aatcctttaa     3600

gcatcttaaa catttttttt ttgaagagaa gttacaaata acatttctat caggtagtac     3660

ttgtatgaaa ccacctttct tattctataa ttttgatttt tcaattttat atacttaata     3720

tactcactgt cttactatca gaaagttatt ttgaccaaga tttttattat cttcatagat     3780

tcagaaagag atgctaattc tgtaccaatg tcttcctggt tactattctc ttccctctaa     3840

tatatactgg ccatttgtaa aaccattgtg ttgttgggat cacttagtta tactatacgc     3900

agatagagca tctcaactct gtcatagtgt ttgctgaaca gttttcagtg tcatgcacct     3960

ttggctgcta attgttcctg acgtgcactc ttccgagttg gtaaaggcac agtgtgttca     4020

tgccagactt ctaagagaaa caccagcctc ttaaatcaga agcctacaca caaccccctt     4080

aacaatccaa agaagcttga tggtgtgcaa agaagcatcc tgccagcctt gtcattgttc     4140

tgttctatgc taatcctgct gtgttgtcta aaagatggag ggaagaggac atcagtgtct     4200

gatagtgaaa tcatcagcag gaaagtgaag ctctttcctt ggttacagat aagacttggt     4260

ttacactatt ggccagtatc tgctaaacat atgaagactt aactattcag tgttgcctag     4320

gcattcgcct gcacaacatt ttgaggttag aacatagaat attttcagaa atactgttgt     4380

agtttgtgag tgttgttcat tagttacaca ttagctatag agtggatgca tgaagcccca     4440

tgacaccagt aaacttctct taccagtagg taaaccaaac accattctgt cattagcagc     4500

cctcttaaat gttgcctctc cgtatcctgt tgcatttttg tgtgcattgt gtttctactg     4560

atctctctta ggtttttacg gaatcaaagg aaactaattt ttccttaata gcaagaaaga     4620

tgaagaggta aagggcattg aagcagaaat gtatagtttg gggtacgatt agaaaactcg     4680

taaggaaaac agaagtccta atttcaaact gactgctctt cgttaagtgc tcttaaggag     4740

agtctagtaa cagtaacact ttctggccat ttctagttta gattctcttc gttactgaaa     4800

cttttgagaa atattacctg tggattaatt ttgcacaatg ttctattctc ataatgactt     4860

acaaattaaa ctaggttttt attgaactac ctcacactaa ttttctatgc tttcccaagt     4920

aagctgttgc cctgttagat ctttactgag tgaattataa atgtgtgtta aatactttct     4980

agccaatgtt gacacaatac cagtaagtat gtaaagtata taccttacat cagtaagaga     5040

cacgtgtaaa atctttgact gtatgtcttg caaaattgtg ctcgttgaca ttattactgt     5100

ttttgtaagt agaaacctgc tcgtgatatc ggtccattta cattttacaa aaggagtaaa     5160

tcttagtaaa aattttacga agaaataaat tacttttgta ggcccaatat ttggtatatt     5220

tttgagaagc tgttaatctt ttagctgaat aatgaagtta gactgaatta cgtgtctccc     5280

tggactgtga catctatttt ctcattacag tttatcctgg tcagcagggt gtcacacctg     5340

gaaacctgag tatgatagct gacatttgct tttctccctc tgcgatgtca ttcctcctcc     5400

attcctctcc ttccctgtgt tccgttccct ctcctttcct ctagacaaaa caaaatgggg     5460

cactttttag ggaatgctga gatcattatt gtggtttttc atcattcatg ccctagtcat     5520

taaacatgca ccactggaat gtaaacaatg ttatctagta tgtcaattgg ttataatatt     5580

ttaaataaaa aagaaaaaag tggtatgaaa attatgaaa                            5619


<210>  33
<211>  427
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  33

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  34
<211>  5449
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  34
cacacaggaa ggagccgagt gggactttcc tctcgctgcc tcccggctct gcccgccctt       60

cgaaagtcca gggtccctgc ccgctaggca agttgcactc atggcacctc caagtgaaga      120

gacgcccctg atccctcagc gttcatgcag cctcttgtcc acggaggctg gtgccctgca      180

tgtgctgctg cccgctcggg gccccgggcc cccccagcgc ctatctttct cctttgggga      240

ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc agcggcatcc tgcctgtgta      300

ccactccctc tttgctctgg ccacggagga cctgtcctgc tggttccccc cgagccacat      360

cttctccgtg gaggatgcca gcacccaagt cctgctgtac aggattcgct tttacttccc      420

caattggttt gggctggaga agtgccaccg cttcgggcta cgcaaggatt tggccagtgc      480

tatccttgac ctgccagtcc tggagcacct ctttgcccag caccgcagtg acctggtgag      540

tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt gagtgtctca gcctggccgt      600

gttggacctg gcccggatgg cgcgagagca ggcccagcgg ccgggagagc tgctgaagac      660

tgtcagctac aaggcctgcc tacccccaag cctgcgcgac ctgatccagg gcctgagctt      720

cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc ctgcgccgcg tggccgcctg      780

ccaggcagac cggcactcgc tcatggccaa gtacatcatg gacctggagc ggctggatcc      840

agccggggcc gccgagacct tccacgtggg cctccctggg gcccttggtg gccacgacgg      900

gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc tggacccagg gagaacagga      960

ggtcctccag cccttctgcg actttccaga aatcgtagac attagcatca agcaggcccc     1020

gcgcgttggc ccggccggag agcaccgcct ggtcactgtt accaggacag acaaccagat     1080

tttagaggcc gagttcccag ggctgcccga ggctctgtcg ttcgtggcgc tcgtggacgg     1140

ctacttccgg ctgaccacgg actcccagca cttcttctgc aaggaggtgg caccgccgag     1200

gctgctggag gaagtggccg agcagtgcca cggccccatc actctggact ttgccatcaa     1260

caagctcaag actgggggct cacgtcctgg ctcctatgtt ctccgccgca gcccccagga     1320

ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc cttggtcctg attataaggg     1380

ctgcctcatc cggcgcagcc ccacaggaac cttccttctg gttggcctca gccgacccca     1440

cagcagtctt cgagagctcc tggcaacctg ctgggatggg gggctgcacg tagatggggt     1500

ggcagtgacc ctcacttcct gctgtatccc cagacccaaa gaaaagtcca acctgatcgt     1560

ggtccagaga ggtcacagcc cacccacatc atccttggtt cagccccaat cccaatacca     1620

gctgagtcag atgacatttc acaagatccc tgctgacagc ctggagtggc atgagaacct     1680

gggccatggg tccttcacca agatttaccg gggctgtcgc catgaggtgg tggatgggga     1740

ggcccgaaag acagaggtgc tgctgaaggt catggatgcc aagcacaaga actgcatgga     1800

gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg taccggcatc tcgtgctgct     1860

ccacggcgtg tgcatggctg gagacagcac catggtgcag gaatttgtac acctgggggc     1920

catagacatg tatctgcgaa aacgtggcca cctggtgcca gccagctgga agctgcaggt     1980

ggtcaaacag ctggcctacg ccctcaacta tctggaggac aaaggcctgc cccatggcaa     2040

tgtctctgcc cggaaggtgc tcctggctcg ggagggggct gatgggagcc cgcccttcat     2100

caagctgagt gaccctgggg tcagccccgc tgtgttaagc ctggagatgc tcaccgacag     2160

gatcccctgg gtggcccccg agtgtctccg ggaggcgcag acacttagct tggaagctga     2220

caagtggggc ttcggcgcca cggtctggga agtgtttagt ggcgtcacca tgcccatcag     2280

tgccctggat cctgctaaga aactccaatt ttatgaggac cggcagcagc tgccggcccc     2340

caagtggaca gagctggccc tgctgattca acagtgcatg gcctatgagc cggtccagag     2400

gccctccttc cgagccgtca ttcgtgacct caatagcctc atctcttcag actatgagct     2460

cctctcagac cccacacctg gtgccctggc acctcgtgat gggctgtgga atggtgccca     2520

gctctatgcc tgccaagacc ccacgatctt cgaggagaga cacctcaagt acatctcaca     2580

gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc tatgacccgc taggcgacaa     2640

tacaggtgcc ctggtggccg tgaaacagct gcagcacagc gggccagacc agcagaggga     2700

ctttcagcgg gagattcaga tcctcaaagc actgcacagt gatttcattg tcaagtatcg     2760

tggtgtcagc tatggcccgg gccgccagag cctgcggctg gtcatggagt acctgcccag     2820

cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc ctcgatgcca gccgcctcct     2880

tctctattcc tcgcagatct gcaagggcat ggagtacctg ggctcccgcc gctgcgtgca     2940

ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag gcacacgtca agatcgctga     3000

cttcggccta gctaagctgc tgccgcttga caaagactac tacgtggtcc gcgagccagg     3060

ccagagcccc attttctggt atgcccccga atccctctcg gacaacatct tctctcgcca     3120

gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc ttcacctact gcgacaaaag     3180

ctgcagcccc tcggccgagt tcctgcggat gatgggatgt gagcgggatg tccccgccct     3240

ctgccgcctc ttggaactgc tggaggaggg ccagaggctg ccggcgcctc ctgcctgccc     3300

tgctgaggtt cacgagctca tgaagctgtg ctgggcccct agcccacagg accggccatc     3360

attcagcgcc ctgggccccc agctggacat gctgtggagc ggaagccggg ggtgtgagac     3420

tcatgccttc actgctcacc cagagggcaa acaccactcc ctgtcctttt catagctcct     3480

gcccgcagac ctctggatta ggtctctgtt gactggctgt gtgaccttag gcccggagct     3540

gcccctctct gggcctcaga ggccttatga gggtcctcta cttcaggaac acccccatga     3600

cattgcattt gggggggctc ccgtggcctg tagaatagcc tgtggccttt gcaatttgtt     3660

aaggttcaag acagatgggc atatgtgtca gtggggctct ctgagtcctg gcccaaagaa     3720

gcaaggaacc aaatttaaga ctctcgcatc ttcccaaccc cttaagccct ggccccctga     3780

gtttcctttt ctgtctctct ctttttattt tttttatttt tatttttatt tttgagacag     3840

agcctcgctc tgttacccag ggtggagtgc agtggtgcga tctcggctca gtgcaacctc     3900

tgcttcccag gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggt     3960

gtgcaccacc acacccggct aatttttttt atttttaata gagatgaggt ttcaccatga     4020

tggccaggct gatctcgaac tcctaacctc aagtgatcct cccacctcag cctcccaaag     4080

tgttggaata ataggcatga gccactgcac ccaggctttt ttttttttaa atttattatt     4140

attattttta agagacagga tcttgctacg ttgcccaggc tggtcttgaa ctcctgggct     4200

acagtgatcc tcctgcctta tcctcctaaa tagctgggac tacagcacct agttttgagt     4260

ttcctgtctt atttccaatg gggacattca tgtagctttt tttttttttt tttttttgag     4320

acggagtctc gctctgtcgc ccaggctgga gtacagtggc gcaatctagg ctcactgcaa     4380

gctccgcctc ctgggttcac accattctct cgcctcagcc tcccaagtag ctgggactac     4440

aggcgcccgc caccacaccc ggctaatttt ttgtattttt agtagagacg gggtttcacc     4500

ttgttagcca ggatggtttc catctcctga cctcgtgatc tgcccgtctc ggcctcccaa     4560

agtgctggga ttacaggcat gagccactgc gcccggccct catgtagctt taaatgtatg     4620

atctgacttc tgctccccga tctctgtttc tctggaggaa gccaaggaca agagcagttg     4680

ctgtggctgg gactctgcct tttaggggag cccgtgtatc tctttgggat cctgaaaggg     4740

ggcaggaaag gctggggtcc cagtccaccc taatggtatc tgagtgtcct agggcttcag     4800

ttttcccacc tgtccaatgg gaccctttct gtcctcaccc tacaaggggc acaaagggat     4860

gacaccaaac ctggcaggaa cttttcacgc aatcaaggga aggaaaggca ttcctggcag     4920

agggaacagc atgccaagcg tgagaaggct cagagtaagg aggttaagag cccaagtatt     4980

ggagcctaca gttttgcccc ttccatgcag tgtgacagtg ggcaagttcc tttccctctc     5040

tgggtctcag ttctgtcccc tgcaaaatgg tcagagctta ccccttggct gtgcagggtc     5100

aactttctga ctggtgagag ggattctcat gcaggttaag cttctgctgc tcctcctcac     5160

ctgcaaagct tttctgccac ttttgcctcc ttggaaaact cttatccatc tctcaaaact     5220

ccagctacca catccttgca gccttccctc atataccccc actactactg tagccctgtc     5280

cttccctcca gccccactct ggccctgggg ctggggaagt gtctgtgtcc agctgtctcc     5340

cctgacctca gggttccttg ggggctgggc tgaggcctca gtacagaggg ggctctggaa     5400

atgtttgttg actgaataaa ggaattcagt ggaaaaaaaa aaaaaaaaa                 5449


<210>  35
<211>  1124
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  35

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Ser Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Ser Phe Tyr Phe Pro Asn Trp Phe Gly 
            100                 105                 110         


Leu Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala 
        115                 120                 125             


Ile Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser 
    130                 135                 140                 


Asp Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg 
                165                 170                 175     


Glu Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys 
            180                 185                 190         


Ala Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe 
        195                 200                 205             


Val Thr Arg Arg Ala Ile Arg Arg Thr Val Arg Arg Ala Leu Pro Arg 
    210                 215                 220                 


Val Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile 
225                 230                 235                 240 


Met Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His 
                245                 250                 255     


Val Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Phe 
            260                 265                 270         


Arg Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Glu Pro 
                885                 890                 895     


Glu Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  36
<211>  8256
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  36
gtgtgactgg gtctgtgtga gggagagagt gtgtgtggtg tggaggtgaa acggaggcaa       60

gaaagggggc tacctcagga gcgagggaca aagggggcgt gaggcaccta ggccgcggca      120

ccccggcgac aggaagccgt cctgaaccgg gctaccgggt aggggaaggg cccgcgtagt      180

cctcgcaggg ccccagagct ggagtcggct ccacagcccc gggccgtcgg cttctcactt      240

cctggacctc cccggcgccc gggcctgagg actggctcgg cggagggaga agaggaaaca      300

gacttgagca gctccccgtt gtctcgcaac tccactgccg aggaactctc atttcttccc      360

tcgctccttc accccccacc tcatgtagaa gggtgctgag gcgtcgggag ggaggaggag      420

cctgggctac cgtccctgcc ctccccaccc ccttcccggg gcgctttggt gggcgtggag      480

ttggggttgg gggggtgggt gggggttgct ttttggagtg ctggggaact tttttccctt      540

cttcaggtca ggggaaaggg aatgcccaat tcagagagac atgggggcaa gaaggacggg      600

agtggaggag cttctggaac tttgcagccg tcatcgggag gcggcagctc taacagcaga      660

gagcgtcacc gcttggtatc gaagcacaag cggcataagt ccaaacactc caaagacatg      720

gggttggtga cccccgaagc agcatccctg ggcacagtta tcaaaccttt ggtggagtat      780

gatgatatca gctctgattc cgacaccttc tccgatgaca tggccttcaa actagaccga      840

agggagaacg acgaacgtcg tggatcagat cggagcgacc gcctgcacaa acatcgtcac      900

caccagcaca ggcgttcccg ggacttacta aaagctaaac agaccgaaaa agaaaaaagc      960

caagaagtct ccagcaagtc gggatcgatg aaggaccgga tatcgggaag ttcaaagcgt     1020

tcgaatgagg agactgatga ctatgggaag gcgcaggtag ccaaaagcag cagcaaggaa     1080

tccaggtcat ccaagctcca caaggagaag accaggaaag aacgggagct gaagtctggg     1140

cacaaagacc ggagtaaaag tcatcgaaaa agggaaacac ccaaaagtta caaaacagtg     1200

gacagcccaa aacggagatc caggagcccc cacaggaagt ggtctgacag ctccaaacaa     1260

gatgatagcc cctcgggagc ttcttatggc caagattatg accttagtcc ctcacgatct     1320

catacctcga gcaattatga ctcctacaag aaaagtcctg gaagtacctc gagaaggcag     1380

tcggtcagtc ccccttacaa ggagccttcg gcctaccagt ccagcacccg gtcaccgagc     1440

ccctacagta ggcgacagag atctgtcagt ccctatagca ggagacggtc gtccagctac     1500

gaaagaagtg gctcttacag cgggcgatcg cccagtccct atggtcgaag gcggtccagc     1560

agccctttcc tgagcaagcg gtctctgagt cggagtccac tccccagtag gaaatccatg     1620

aagtccagaa gtagaagtcc tgcatattca agacattcat cttctcatag taaaaagaag     1680

agatccagtt cacgcagtcg tcattccagt atctcacctg tcaggcttcc acttaattcc     1740

agtctgggag ctgaactcag taggaaaaag aaggaaagag cagctgctgc tgctgcagca     1800

aagatggatg gaaaggagtc caagggttca cctgtatttt tgcctagaaa agagaacagt     1860

tcagtagagg ctaaggattc aggtttggag tctaaaaagt tacccagaag tgtaaaattg     1920

gaaaaatctg ccccagatac tgaactggtg aatgtaacac atctaaacac agaggtaaaa     1980

aattcttcag atacagggaa agtaaagttg gatgagaact ccgagaagca tcttgttaaa     2040

gatttgaaag cacagggaac aagagactct aaacccatag cactgaaaga ggagattgtt     2100

actccaaagg agacagaaac atcagaaaag gagacccctc cacctcttcc cacaattgct     2160

tctcccccac cccctctacc aactactacc cctccacctc agacaccccc tttgccacct     2220

ttgcctccaa taccagctct tccacagcaa ccacctctgc ctccttctca gccagcattt     2280

agtcaggttc ctgcttccag tacttcaact ttgccccctt ctactcactc aaagacatct     2340

gctgtgtcct ctcaggcaaa ttctcagccc cctgtacagg tttctgtgaa gactcaagta     2400

tctgtaacag ctgctattcc acacctgaaa acttcaacgt tgcctccttt gcccctccca     2460

cccttattac ctggagatga tgacatggat agtccaaaag aaactcttcc ttcaaaacct     2520

gtgaagaaag agaaggaaca gaggacacgt cacttactca cagaccttcc tctccctcca     2580

gagctccctg gtggagatct gtctccccca gactctccag aaccaaaggc aatcacacca     2640

cctcagcaac catataaaaa gagaccaaaa atttgttgtc ctcgttatgg agaaagaaga     2700

caaacagaaa gcgactgggg gaaacgctgt gtggacaagt ttgacattat tgggattatt     2760

ggagaaggaa cctatggcca agtatataaa gccaaggaca aagacacagg agaactagtg     2820

gctctgaaga aggtgagact agacaatgag aaagagggct tcccaatcac agccattcgt     2880

gaaatcaaaa tccttcgtca gttaatccac cgaagtgttg ttaacatgaa ggaaattgtc     2940

acagataaac aagatgcact ggatttcaag aaggacaaag gtgcctttta ccttgtattt     3000

gagtatatgg accatgactt aatgggactg ctagaatctg gtttggtgca cttttctgag     3060

gaccatatca agtcgttcat gaaacagcta atggaaggat tggaatactg tcacaaaaag     3120

aatttcctgc atcgggatat taagtgttct aacattttgc tgaataacag tgggcaaatc     3180

aaactagcag attttggact tgctcggctc tataactctg aagagagtcg cccttacaca     3240

aacaaagtca ttactttgtg gtaccgacct ccagaactac tgctaggaga ggaacgttac     3300

acaccagcca tagatgtttg gagctgtgga tgtattcttg gggaactatt cacaaagaag     3360

cctatttttc aagccaatct ggaactggct cagctagaac tgatcagccg actttgtggt     3420

agcccttgtc cagctgtgtg gcctgatgtt atcaaactgc cctacttcaa caccatgaaa     3480

ccgaagaagc aatatcgaag gcgtctacga gaagaattct ctttcattcc ttctgcagca     3540

cttgatttat tggaccacat gctgacacta gatcctagta agcggtgcac agctgaacag     3600

accctacaga gcgacttcct taaagatgtc gaactcagca aaatggctcc tccagacctc     3660

ccccactggc aggattgcca tgagttgtgg agtaagaaac ggcgacgtca gcgacaaagt     3720

ggtgttgtag tcgaagagcc acctccatcc aaaacttctc gaaaagaaac tacctcaggg     3780

acaagtactg agcctgtgaa gaacagcagc ccagcaccac ctcagcctgc tcctggcaag     3840

gtggagtctg gggctgggga tgcaataggc cttgctgaca tcacacaaca gctgaatcaa     3900

agtgaattgg cagtgttatt aaacctgctg cagagccaaa ccgacctgag catccctcaa     3960

atggcacagc tgcttaacat ccactccaac ccagagatgc agcagcagct ggaagccctg     4020

aaccaatcca tcagtgccct gacggaagct acttcccagc agcaggactc agagaccatg     4080

gccccagagg agtctttgaa ggaagcaccc tctgccccag tgatcctgcc ttcagcagaa     4140

cagacgaccc ttgaagcttc aagcacacca gctgacatgc agaatatatt ggcagttctc     4200

ttgagtcagc tgatgaaaac ccaagagcca gcaggcagtc tggaggaaaa caacagtgac     4260

aagaacagtg ggccacaggg gccccgaaga actcccacaa tgccacagga ggaggcagca     4320

gagaagaggc cccctgagcc ccccggacct ccaccgccgc cacctccacc ccctctggtt     4380

gaaggcgatc tttccagcgc cccccaggag ttgaacccag ccgtgacagc cgccttgctg     4440

caacttttat cccagcctga agcagagcct cctggccacc tgccacatga gcaccaggcc     4500

ttgagaccaa tggagtactc cacccgaccc cgtccaaaca ggacttatgg aaacactgat     4560

gggcctgaaa cagggttcag tgccattgac actgatgaac gaaactctgg tccagccttg     4620

acagaatcct tggtccagac cctggtgaag aacaggacct tctcaggctc tctgagccac     4680

cttggggagt ccagcagtta ccagggcaca gggtcagtgc agtttccagg ggaccaggac     4740

ctccgttttg ccagggtccc cttagcgtta cacccggtgg tcgggcaacc attcctgaag     4800

gctgagggaa gcagcaattc tgtggtacat gcagagacca aattgcaaaa ctatggggag     4860

ctggggccag gaaccactgg ggccagcagc tcaggagcag gccttcactg ggggggccca     4920

actcagtctt ctgcttatgg aaaactctat cgggggccta caagagtccc accaagaggg     4980

ggaagaggga gaggagttcc ttactaaccc agagacttca gtgtcctgaa agattccttt     5040

cctatccatc cttccatcca gttctctgaa tctttaatga aatcatttgc cagagcgagg     5100

taatcatctg catttggcta ctgcaaagct gtccgttgta ttccttgctc acttgctact     5160

agcaggcgac ttacgaaata atgatgttgg caccagttcc ccctggatgg gctatagcca     5220

gaacatttac ttcaactcta ccttagtaga tacaagtaga gaatatggag aggatcatta     5280

cattgaaaag taaatgtttt attagttcat tgcctgcact tactgatcgg aagagagaaa     5340

gaacagtttc agtattgaga tggctcagga gaggctcttt gatttttaaa gttttggggt     5400

gggggattgt gtgtggtttc tttcttttga attttaattt aggtgttttg ggtttttttc     5460

ctttaaagag aatagtgttc acaaaatttg agctgctctt tggcttttgc tataagggaa     5520

acagagtggc ctggctgatt tgaataaatg tttctttcct ctccaccatc tcacattttg     5580

cttttaagtg aacacttttt ccccattgag catcttgaac atactttttt tccaaataaa     5640

ttactcatcc ttaaagttta ctccactttg acaaaagata cgcccttctc cctgcacata     5700

aagcaggttg tagaacgtgg cattcttggg caagtaggta gactttaccc agtctctttc     5760

cttttttgct gatgtgtgct ctctctctct ctttctctct ctctctctct ctctctctct     5820

ctctctctct ctctgtctcg cttgctcgct ctcgctgttt ctctctcttt gaggcatttg     5880

tttggaaaaa atcgttgaga tgcccaagaa cctgggataa ttctttactt tttttgaaat     5940

aaaggaaagg aaattcagac tcttacattg ttctctgtaa ctcttcaatt ctaaaatgtt     6000

ttgtttttta aaccatgttc tgatggggaa gttgatttgt aagtgtggac agcttggaca     6060

ttgctgctga gctgtggtta gagatgatgc ctccattcct agagggctaa taacagcatt     6120

tagcatattg tttacacata tatttttatg tcaaaaaaaa aacaaaaacc tttcaaacag     6180

agcattgtga tattgtcaaa gagaaaaaca aatcctgaag atacatggaa atgtaaccta     6240

gtttagggtg ggtatttttc tgaagataca tcaatacctg acctttttta aaaaaataat     6300

tttaaaacag catactgtga ggaagaacag tattgacata cccacatccc agcatgtgta     6360

ccctgccagt tcttttaggg atttttcctc caaagagatt tggatttggt tttggtaaaa     6420

ggggttaaat tgtgcttcca ggcaagaact ttgccttatc ataaacagga aatgaaaaag     6480

ggaagggctg tcaggatggg ataatttggg aggcttctca ttctggcttc tatttctatg     6540

tgagtaccag catatagagt gttttaaaaa cagatacatg tcatataatt tatctgcaca     6600

gacttagacc ttcaggaaac ataggttaag ccccctttta caaagaaaaa gtaaacatac     6660

ttcagcatct tggagggtag ttttcaaaac tcaagtttca tgtttcaatg ccaagttctt     6720

attttaaaaa ataaaatcta cttataagag aaaggtgcat tacttaaaaa aaaaaaactt     6780

taaagaaatg aaagaagaac cctcttcaga tacttacttg aagactgttt tcccctgtta     6840

atgagatata gctagatatc ggtgtgtgta tttctttatt attctctggt ttttgatctg     6900

gccttgcctc cagggccaaa cactgattta gaaagagagc cttctagcta ttttggcatt     6960

gatggctttt tataccagtg tgtccagtta gatttactag gcttactgac atgctattgg     7020

taaatcgcat taaagttcat ctgaaccttc tgtctgttga cttcttagtc ctcagacatg     7080

ggcctttgtg ttttagaata tttgaatttg agttattggg ccccactccc tgttttttat     7140

taaagaacgt gagcctggga tactttcaga agtatctgtt caatgaaaaa aagttggttt     7200

cccatcaaat atgaataaaa ttctctatat atttcattgt attttggtta tcagcagtca     7260

tcaataatgt ttttccctcc cctctcccac ctcttatttt taattatgcc aaatatccta     7320

aataatatac ttaagcctcc attccctcat ccctactagg gaagggggtg agtgtatgtg     7380

tgagtgtatg tgtatgtatg atcccatctc acccccaccc ccattttggg agtcttttaa     7440

aatgaaaaca aagtttggta gttttgacta tttctaaaag cagaggagaa aaaaaaactt     7500

atttaaatat cctggaatct gtatggagga agaaaaggta tttgttaatt tttcagttac     7560

gttatctata aacatgatgg aagtaaaggt ttggcagaat ttcaccttga ctatttgaaa     7620

attacagacc caattaattc cattcaaaag tggttttcgt tttgttttaa ttattgtaca     7680

atgagagata ttgtctatta aatacattat tttgaacaga tgagaaatct gattctgttc     7740

atgagtggga ggcaaaactg gtttgaccgt gatcattttt gtggttttga aaacaaatat     7800

acttgaccca gtttccttag ttttttcttc aactgtccat aggaacgata agtatttgaa     7860

agcaacatca aatctatacg tttaaagcag ggcagttagc acaaatttgc aagtagaact     7920

tctattagct tatgccatag acatcaccca accacttgta tgtgtgtgtg tatatataat     7980

atgcatatat agttaccgtg ctaaaatggt taccagcagg ttttgagaga gaatgctgca     8040

tcagaaaagt gtcagttgcc acctcattct ccctgattta ggttcctgac actgattcct     8100

ttctctctcg tttttgaccc ccattgggtg tatcttgtct atgtacagat attttgtaat     8160

atattaaatt tttttctttc agtttataaa aatggaaagt ggagattgga aaattaaata     8220

tttcctgtta ctataccact tttgctccat tgcatt                               8256


<210>  37
<211>  1490
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  37

Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly 
1               5                   10                  15      


Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser 
            20                  25                  30          


Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys 
        35                  40                  45              


His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly 
    50                  55                  60                  


Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser 
65                  70                  75                  80  


Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn 
                85                  90                  95      


Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg 
            100                 105                 110         


His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr 
        115                 120                 125             


Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys 
    130                 135                 140                 


Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp 
145                 150                 155                 160 


Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser 
                165                 170                 175     


Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser 
            180                 185                 190         


Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys 
        195                 200                 205             


Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His 
    210                 215                 220                 


Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala 
225                 230                 235                 240 


Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser 
                245                 250                 255     


Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg 
            260                 265                 270         


Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser 
        275                 280                 285             


Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro 
    290                 295                 300                 


Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser 
305                 310                 315                 320 


Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe 
                325                 330                 335     


Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser 
            340                 345                 350         


Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser 
        355                 360                 365             


His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile 
    370                 375                 380                 


Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp 
                405                 410                 415     


Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn 
            420                 425                 430         


Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro 
        435                 440                 445             


Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn 
    450                 455                 460                 


Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys 
465                 470                 475                 480 


Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys 
                485                 490                 495     


Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile 
            500                 505                 510         


Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro 
        515                 520                 525             


Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro 
    530                 535                 540                 


Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu 
545                 550                 555                 560 


Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val 
                565                 570                 575     


Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr 
            580                 585                 590         


Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser 
        595                 600                 605             


Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr 
    610                 615                 620                 


Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Asp Asp 
625                 630                 635                 640 


Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys 
                645                 650                 655     


Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro 
            660                 665                 670         


Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro 
        675                 680                 685             


Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile 
    690                 695                 700                 


Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly 
705                 710                 715                 720 


Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly 
                725                 730                 735     


Thr Tyr Gly Gln Val Tyr Lys Ala Lys Asp Lys Asp Thr Gly Glu Leu 
            740                 745                 750         


Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro 
        755                 760                 765             


Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg 
    770                 775                 780                 


Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu 
785                 790                 795                 800 


Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met 
                805                 810                 815     


Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser 
            820                 825                 830         


Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu 
        835                 840                 845             


Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn 
    850                 855                 860                 


Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu 
865                 870                 875                 880 


Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val 
                885                 890                 895     


Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg 
            900                 905                 910         


Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu 
        915                 920                 925             


Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln 
    930                 935                 940                 


Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp 
945                 950                 955                 960 


Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys 
                965                 970                 975     


Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala 
            980                 985                 990         


Ala Leu Asp Leu Leu Asp His Met  Leu Thr Leu Asp Pro  Ser Lys Arg 
        995                 1000                 1005             


Cys Thr  Ala Glu Gln Thr Leu  Gln Ser Asp Phe Leu  Lys Asp Val 
    1010                 1015                 1020             


Glu Leu  Ser Lys Met Ala Pro  Pro Asp Leu Pro His  Trp Gln Asp 
    1025                 1030                 1035             


Cys His  Glu Leu Trp Ser Lys  Lys Arg Arg Arg Gln  Arg Gln Ser 
    1040                 1045                 1050             


Gly Val  Val Val Glu Glu Pro  Pro Pro Ser Lys Thr  Ser Arg Lys 
    1055                 1060                 1065             


Glu Thr  Thr Ser Gly Thr Ser  Thr Glu Pro Val Lys  Asn Ser Ser 
    1070                 1075                 1080             


Pro Ala  Pro Pro Gln Pro Ala  Pro Gly Lys Val Glu  Ser Gly Ala 
    1085                 1090                 1095             


Gly Asp  Ala Ile Gly Leu Ala  Asp Ile Thr Gln Gln  Leu Asn Gln 
    1100                 1105                 1110             


Ser Glu  Leu Ala Val Leu Leu  Asn Leu Leu Gln Ser  Gln Thr Asp 
    1115                 1120                 1125             


Leu Ser  Ile Pro Gln Met Ala  Gln Leu Leu Asn Ile  His Ser Asn 
    1130                 1135                 1140             


Pro Glu  Met Gln Gln Gln Leu  Glu Ala Leu Asn Gln  Ser Ile Ser 
    1145                 1150                 1155             


Ala Leu  Thr Glu Ala Thr Ser  Gln Gln Gln Asp Ser  Glu Thr Met 
    1160                 1165                 1170             


Ala Pro  Glu Glu Ser Leu Lys  Glu Ala Pro Ser Ala  Pro Val Ile 
    1175                 1180                 1185             


Leu Pro  Ser Ala Glu Gln Thr  Thr Leu Glu Ala Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Asp  Met Gln Asn Ile Leu  Ala Val Leu Leu Ser  Gln Leu Met 
    1205                 1210                 1215             


Lys Thr  Gln Glu Pro Ala Gly  Ser Leu Glu Glu Asn  Asn Ser Asp 
    1220                 1225                 1230             


Lys Asn  Ser Gly Pro Gln Gly  Pro Arg Arg Thr Pro  Thr Met Pro 
    1235                 1240                 1245             


Gln Glu  Glu Ala Ala Ala Cys  Pro Pro His Ile Leu  Pro Pro Glu 
    1250                 1255                 1260             


Lys Arg  Pro Pro Glu Pro Pro  Gly Pro Pro Pro Pro  Pro Pro Pro 
    1265                 1270                 1275             


Pro Pro  Leu Val Glu Gly Asp  Leu Ser Ser Ala Pro  Gln Glu Leu 
    1280                 1285                 1290             


Asn Pro  Ala Val Thr Ala Ala  Leu Leu Gln Leu Leu  Ser Gln Pro 
    1295                 1300                 1305             


Glu Ala  Glu Pro Pro Gly His  Leu Pro His Glu His  Gln Ala Leu 
    1310                 1315                 1320             


Arg Pro  Met Glu Tyr Ser Thr  Arg Pro Arg Pro Asn  Arg Thr Tyr 
    1325                 1330                 1335             


Gly Asn  Thr Asp Gly Pro Glu  Thr Gly Phe Ser Ala  Ile Asp Thr 
    1340                 1345                 1350             


Asp Glu  Arg Asn Ser Gly Pro  Ala Leu Thr Glu Ser  Leu Val Gln 
    1355                 1360                 1365             


Thr Leu  Val Lys Asn Arg Thr  Phe Ser Gly Ser Leu  Ser His Leu 
    1370                 1375                 1380             


Gly Glu  Ser Ser Ser Tyr Gln  Gly Thr Gly Ser Val  Gln Phe Pro 
    1385                 1390                 1395             


Gly Asp  Gln Asp Leu Arg Phe  Ala Arg Val Pro Leu  Ala Leu His 
    1400                 1405                 1410             


Pro Val  Val Gly Gln Pro Phe  Leu Lys Ala Glu Gly  Ser Ser Asn 
    1415                 1420                 1425             


Ser Val  Val His Ala Glu Thr  Lys Leu Gln Asn Tyr  Gly Glu Leu 
    1430                 1435                 1440             


Gly Pro  Gly Thr Thr Gly Ala  Ser Ser Ser Gly Ala  Gly Leu His 
    1445                 1450                 1455             


Trp Gly  Gly Pro Thr Gln Ser  Ser Ala Tyr Gly Lys  Leu Tyr Arg 
    1460                 1465                 1470             


Gly Pro  Thr Arg Val Pro Pro  Arg Gly Gly Arg Gly  Arg Gly Val 
    1475                 1480                 1485             


Pro Tyr  
    1490 


<210>  38
<211>  7091
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  38
gctgagtcat cactagagag tgggaagggc agcagcagca gagaatccaa accctaaagc       60

tgatatcaca aagtaccatt tctccaagtt gggggctcag aggggagtca tcatgagcga      120

tgttaccatt gtgaaagaag gttgggttca gaagagggga gaatatataa aaaactggag      180

gccaagatac ttccttttga agacagatgg ctcattcata ggatataaag agaaacctca      240

agatgtggat ttaccttatc ccctcaacaa cttttcagtg gcaaaatgcc agttaatgaa      300

aacagaacga ccaaagccaa acacatttat aatcagatgt ctccagtgga ctactgttat      360

agagagaaca tttcatgtag atactccaga ggaaagggaa gaatggacag aagctatcca      420

ggctgtagca gacagactgc agaggcaaga agaggagaga atgaattgta gtccaacttc      480

acaaattgat aatataggag aggaagagat ggatgcctct acaacccatc ataaaagaaa      540

gacaatgaat gattttgact atttgaaact actaggtaaa ggcacttttg ggaaagttat      600

tttggttcga gagaaggcaa gtggaaaata ctatgctatg aagattctga agaaagaagt      660

cattattgca aaggatgaag tggcacacac tctaactgaa agcagagtat taaagaacac      720

tagacatccc tttttaacat ccttgaaata ttccttccag acaaaagacc gtttgtgttt      780

tgtgatggaa tatgttaatg ggggcgagct gtttttccat ttgtcgagag agcgggtgtt      840

ctctgaggac cgcacacgtt tctatggtgc agaaattgtc tctgccttgg actatctaca      900

ttccggaaag attgtgtacc gtgatctcaa gttggagaat ctaatgctgg acaaagatgg      960

ccacataaaa attacagatt ttggactttg caaagaaggg atcacagatg cagccaccat     1020

gaagacattc tgtggcactc cagaatatct ggcaccagag gtgttagaag ataatgacta     1080

tggccgagca gtagactggt ggggcctagg ggttgtcatg tatgaaatga tgtgtgggag     1140

gttacctttc tacaaccagg accatgagaa actttttgaa ttaatattaa tggaagacat     1200

taaatttcct cgaacactct cttcagatgc aaaatcattg ctttcagggc tcttgataaa     1260

ggatccaaat aaacgccttg gtggaggacc agatgatgca aaagaaatta tgagacacag     1320

tttcttctct ggagtaaact ggcaagatgt atatgataaa aagcttgtac ctccttttaa     1380

acctcaagta acatctgaga cagatactag atattttgat gaagaattta cagctcagac     1440

tattacaata acaccacctg aaaaatatga tgaggatggt atggactgca tggacaatga     1500

gaggcggccg catttccctc aattttccta ctctgcaagt ggacgagaat aagtctcttt     1560

cattctgcta cttcactgtc atcttcaatt tattactgaa aatgattcct ggacatcacc     1620

agtcctagct cttacacata gcaggggcac cttccgacat cccagaccag ccaagggtcc     1680

tcacccctcg ccacctttca ccctcatgaa aacacacata cacgcaaata cactccagtt     1740

tttgtttttg catgaaattg tatctcagtc taaggtctca tgctgttgct gctactgtct     1800

tactattata gcaactttaa gaagtaattt tccaaccttt ggaagtcatg agcccaccat     1860

tgttcatttg tgcaccaatt atcatctttt gatcttttag tttttccctc agtgaaggct     1920

aaatgagata cactgattct aggtacattt tttaactttc tagaagagaa aaactaacta     1980

gactaagaag atttagttta taaattcaga acaagcaatt gtggaagggt ggtggcgtgc     2040

atatgtaaag cacatcagat ccgtgcgtga agtaggcata tatcactaag ctgtggctgg     2100

aattgattag gaagcatttg gtagaaggac tgaacaactg ttgggatata tatatatata     2160

tataattttt tttttttaaa ttcctggtgg atactgtaga agaagcccat atcacatgtg     2220

gatgtcgaga cttcacgggc aatcatgagc aagtgaacac tgttctacca agaactgaag     2280

gcatatgcac agtcaaggtc acttaaaggg tcttatgaaa caatttgagc cagagagcat     2340

ctttcccctg tgcttggaaa ccttttttcc ttcttgacat ttatcacctc tgatggctga     2400

agaatgtaga caggtataat gatactgctt ttcaccaaaa tttctacacc aaggtaaaca     2460

ggtgtttgcc ttatttaatt ttttactttc agttctacgt gaattagctt tttctcagat     2520

gttgaaactt tgaatgtcct tttatgattt tgtttatatt gcagtagtat ttatttttta     2580

gtgatgagaa ttgtatgtca tgttagcaaa cgcagctcca acttatataa aatagactta     2640

ctgcagttac ttttgaccca tgtgcaagga ttgtacacgc tgatgagaat catgcacttt     2700

ttctcctctg ttaaaaaaaa tgataaggct ctgaaatgga atatattggt tagaatttgg     2760

ctttgggaga agagatgctg ccatttaacc ccttggtact gaaaatgaga aaatccccaa     2820

ctatgcatgc caaggggtta atgaaacaaa tagctgttga cgtttgctca tttaagaatt     2880

tgaaacgtta tgatgacctg gcaacaaaaa gtaatgaaga aaattgagac ctgagtgaag     2940

ataagaaatg atctttacgt ggcaaaatga acacatcttg agtatttagg aaatgggcag     3000

tgaaggctaa gaacctggtg tgtttcttgg gatcatggta catttatcac tgaattaagc     3060

catcagggaa aaaacaacaa aaaaagagaa cacctccagc ttttcttttt ctgtatatac     3120

tcatgtcccc cagattccaa catttctcac tgaaaggggg catgtatgca aacctcatct     3180

ttctccttca ttaatgatga tcttcagatt aaaccctttg gtgctaggag ctgacaattt     3240

ccaaagcagc ctgtgaagtc ctaggggctg ggggccactc ttgcggcaag cagaaggcca     3300

tcctactccg cggagtgatc atggaaatgt attttagtta aactctgaca gctcccaaac     3360

ggaagactac agcatgacgt agtattatga ttgcattgta tgaaagagca agtgactttc     3420

taagtaggat gaatcatatt catatgcaga tgtcttagcc tcttgacgct ggaagtgtgg     3480

atttatagct atgaaaccac tgctggcagt gggtgggcca ctgggactga cgggggttaa     3540

agggcatttt actaaggcag ctaagacata ttcagacatc aacgttatcc ttctttttca     3600

tatttctacc tgagtgaagt tcatccttag tattgagtag gaagttacag taaatggtag     3660

ttcattctta cttacacaca tagctaatct tttttttttc acttggaatt atgttgaatg     3720

tttcattttg acaaaaaagt agactagaag gtatgttctt taagttgtct tgcatccatt     3780

atataagaaa gaaacaggtg agaggaagag cagaaagctg agactggctg atgttcagag     3840

cacttactcc tctagaggga aagcatgaca ccgaacacta agcacacagc tttttgttgt     3900

tttggttttt tctcccgcaa atcttaaagt gattcccatg accttggcca aggacacttc     3960

ttaaagatta atgactggca ctgacattgc cccaggcggg ccactcctca cactggctct     4020

cagttcccag ccatgcctgg ggctcagtca cttctattcc accctctgag actccattgg     4080

tgtcacacaa ggtgtcttct tggctttgat tttgagaatc ccctattttc acttccagat     4140

ctgtcagctg ccatggagga ataatagaaa accagaaatg cgtgtagagg gagatttcta     4200

aaacttccct tgtgtcgccc atagttgtag ttttgggttc tggcaggtgg aacaccctga     4260

aacctggaat cattctatga gaatacagtt cagactttgc agactccagc ccatactaac     4320

tgtcatgaag cttgacttct tgtcataatg cagccatctt ggaggaaatt ggccatttct     4380

gcttagatgg ttggcagggt cgcgctcagc tttgctttct acactaatta catagcatta     4440

ttcaagtatt gttttccatt tcccatccct gatttccagc ttcttaaagc tgactgttct     4500

tgcaggggcc acttgcttct cctagagtac aaaagtaagg gccttcctta ctaactgcag     4560

ggtctctcta ttacacctca acatacacac tttgctgcta ctgtttgtac tgtctacagt     4620

agaatttcct tatcttgctc ctggtagtgc attacaggca agcatgaaat gtaaagtatt     4680

tatttaaata aaaagaaaac ctctaaattg gtaattgaat tacctccctg tagctttata     4740

gtttgtgaca tttcttgacc ttgctagttc tttcattaga tctgcgcaag atctagtcat     4800

ctggttaagg attttaagca gatgcaacta taaacccaag aaactgtatt actattactg     4860

ttggtcatac taaacctgtc tatttcctga agtatatgac ccacaaggat gtggaataac     4920

taggagaaac tgtttttgta cactgtacat ccttagtatt tttacacgta tatgataggg     4980

atgaacatga ttttccttcg tacagacagc ttaaataaag cactatgtca atctgctact     5040

tctctgttta ttgttgttgg atgtggttct ataatccccc caaattaaat cttctttaat     5100

gaaaacatga tttttaatag ccccagctgg tattaaccta ccttgtataa aatgtgacag     5160

gaaaatatag aaataattcc ttgtagctca cacacacaca cataggggat catttttact     5220

tcagtgaaat ggcagtagtg cggttgtgca aactttgatg aacggctgct tctgagggga     5280

aacgctgacc tctcagcact ggatttagga tggatgtact gtgaagccag ggatgaagga     5340

ggtctcagac cctggggaca ttcagacccg aatcatctat acaacacacg gtttggaccc     5400

agaatctgaa ggaatgtagc ttttcattaa cgtcttcctg ataatgtact gctctgcata     5460

tttcctttct tagagtgtat ttctaacaac atgtcatggc aaattaacaa acttagacgt     5520

gggtgatgta gatgggtagg atggctggac tgcagtctga cttcacgttg aatcattctg     5580

gatggggcct ttttctgatt ttacctcata aagctactat tgtagaaact tggctttgct     5640

cctgtgacga agccagacag aggaatggct tttgggacca gagtgagtca agcatgtatg     5700

tgtatgtcac acggccaaat ttgagggcat tctcacatgt gctcttctct caaaaccact     5760

ggggttgaca gatccaggag gctaaaaaaa agtgacctct ataattcttt aaaggtgcta     5820

tttttagaat attgtataat ttattcacag tatatctaaa acagaattaa ggacaattaa     5880

aatatcttat gtgacagcct ttatgtctag cacatttgat gaaataaaaa acttctgaat     5940

ctgaatagaa gttctactgt ttcaggcttg aaccttttac atgctcaaga gattcaaatg     6000

gtctctgtgt gtagatcatg ccaccgcctc caaagcctaa tccacatcac ttctgagagg     6060

caaggctgag catatggtga catcagctct gtgttgagat ggtgatgagg atgatggctc     6120

gctggccagg cagggcagcc gaaggtcagg gacctgtcct aactaactgc agccttgcct     6180

ttagtgtttg tcattctcag atacaacacg gtatgtccag tgtccgtttt tattacttta     6240

aagcatttga gggcttaatt gtgtatagta gaaatactat tttagacaaa taattatctg     6300

tgtacagata tttgatatac tctaagtaaa ttttctaatt tcactaagta cgtttttagg     6360

ctcctctcaa atactgcgta ttgaagaaaa aaatctgaca ccaccgagcc aaagatgctt     6420

ttttgtctgt tttcgttgtt taacagaatg gaaagagtaa tgcatagtgc ttcctggtgt     6480

ctcctgattg attgattgtg cacaaagtag gacgataaat aaataaaatg gagtctgatg     6540

ggacattgat taaaggtgaa ggatgattga tatatagatc atgaaaagaa aaatgaatgg     6600

caggaaaaaa agtttggtcc ttaatatact ttggcctagt taaaatatgt gcctttttgg     6660

tgtgttttgt tcatcactac aagataaaaa ggaaacatta caactcaagt ctttaaaaag     6720

ttcatttatt gaaaatcata tgtataacct agcatacgaa tgagcagatt taaacacata     6780

acttcaagcc atttctgaaa acatacacca ggagctctgc tcagctagag tcagactcca     6840

gctccagccc gactgcgtgc ggggacagcg cccgcgttga tgaggaccag ccccactgca     6900

ggctgaggcg gtgtcaccct gggaaggtcg tggtgcgttg tggcatatta agtctaaacc     6960

agatgaatgt aaatatctct ttgtaaatca tttatttcac tctgttccat ccaggtcagc     7020

aatcagattg tggcatgctg ggtaactgga aaaaataata aaaagtaagt ttcaatagct     7080

caaaaaaaaa a                                                          7091


<210>  39
<211>  479
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  39

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  40
<211>  816
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  40
accctgggcc ggatgttggg caaaggagag tttggttcag tgcgggaggc ccagctgaag       60

caagaggatg gctcctttgt gaaagtggct gtgaagatgc tgaaagctga catcattgcc      120

tcaagcgaca ttgaagagtt cctcagggaa gcagcttgca tgaaggagtt tgaccatcca      180

cacgtggcca aacttgttgg ggtaagcctc cggagcaggg ctaaaggccg tctccccatc      240

cccatggtca tcttgccctt catgaagcat ggggacctgc atgccttcct gctcgcctcc      300

cggattgggg agaacccctt taacctaccc ctccagaccc tgatccggtt catggtggac      360

attgcctgcg gcatggagta cctgagctct cggaacttca tccaccgaga cctggctgct      420

cggaattgca tgctggcaga ggacatgaca gtgtgtgtgg ctgacttcgg actctcccgg      480

aagatctaca gtggggacta ctatcgtcaa ggctgtgcct ccaaactgcc tgtcaagtgg      540

ctggccctgg agagcctggc cgacaacctg tatactgtgc agagtgacgt gtgggcgttc      600

ggggtgacca tgtgggagat catgacacgt gggcagacgc catatgctgg catcgaaaac      660

gctgagattt acaactacct cattggcggg aaccgcctga aacagcctcc ggagtgtatg      720

gaggacgtgt atgatctcat gtaccagtgc tggagtgctg accccaagca gcgcccgagc      780

tttacttgtc tgcgaatgga actggagaac atcttg                                816


<210>  41
<211>  890
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  41

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  42
<211>  8435
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  42
ccagacacag caggagcgcg ccttggcggt gcagtttcaa cctcgacttc gcagccgcgc       60

acacaccgcc tgctccccga gcagcgggaa ccgcagcagc tcctgggccg ccgcagcgca      120

gctccgcgct cctaccggcc ggcagccgtc agtccctccc ctcttcagca ctcagcccgc      180

agctatttcc ttctgccagt ctctttgaac tctggatctt tgcttttgct cgctgctctc      240

ctgtttttca ttctccacat tttctcaagt cctctttctt tatccttagc caccctgctt      300

ttttcctcct tttttaaaaa atcggagatt tcgtcttaaa atgatttgcc ttccttacct      360

tcgtccattt caacactgaa ggctgcaaag aaccttcacc tttcccctag tggtatttaa      420

aaattctcaa tccgtaaaaa gtctttttga aaggcaaagg aacaggaccc aggaccctct      480

cgacaccctt gatccgagtc cagatctgca ctagcaacca gaactaatat ttcatttaac      540

cccaccaaag ggggaggcga gaggagccag aagcaaactt cagctgtctc agccggatcc      600

gtggttccta catttggagg agccgcgtgc cagaaggcgt aggaccccaa ggggggacaa      660

ggaggactcc cgagtctccc ttcgccgctc tgcgaggccg aagcggtgga ctgagccgct      720

cgggacagcg gcaccggagg aggctcggag aagatgcggg gctcggggcc ccggggtgcg      780

ggacgccggc ggcccccaag cggcggcggc gacaccccca tcaccccagc gtccctggcc      840

ggctgctact ctgcacctcg acgggctccc ctctggacgt gccttctcct gtgcgccgca      900

ctccggaccc tcctggccag ccccagcaac gaagtgaatt tattggattc acgcactgtc      960

atgggggacc tgggatggat tgcttttcca aaaaatgggt gggaagagat tggtgaagtg     1020

gatgaaaatt atgcccctat ccacacatac caagtatgca aagtgatgga acagaatcag     1080

aataactggc ttttgaccag ttggatctcc aatgaaggtg cttccagaat cttcatagaa     1140

ctcaaattta ccctgcggga ctgcaacagc cttcctggag gactggggac ctgtaaggaa     1200

acctttaata tgtattactt tgagtcagat gatcagaatg ggagaaacat caaggaaaac     1260

caatacatca aaattgatac cattgctgcc gatgaaagct ttacagaact tgatcttggt     1320

gaccgtgtta tgaaactgaa tacagaggtc agagatgtag gacctctaag caaaaaggga     1380

ttttatcttg cttttcaaga tgttggtgct tgcattgctc tggtttctgt gcgtgtatac     1440

tataaaaaat gcccttctgt ggtacgacac ttggctgtct tccctgacac catcactgga     1500

gctgattctt cccaattgct cgaagtgtca ggctcctgtg tcaaccattc tgtgaccgat     1560

gaacctccca aaatgcactg cagcgccgaa ggggagtggc tggtgcccat cgggaaatgc     1620

atgtgcaagg caggatatga agagaaaaat ggcacctgtc aagtgtgcag acctgggttc     1680

ttcaaagcct cacctcacat ccagagctgc ggcaaatgtc cacctcacag ttatacccat     1740

gaggaagctt caacctcttg tgtctgtgaa aaggattatt tcaggagaga gtctgatcca     1800

cccacaatgg catgcacaag acccccctct gctcctcgga atgccatctc aaatgttaat     1860

gaaactagtg tctttctgga atggattccg cctgctgaca ctggtggaag gaaagacgtg     1920

tcatattata ttgcatgcaa gaagtgcaac tcccatgcag gtgtgtgtga ggagtgtggc     1980

ggtcatgtca ggtaccttcc ccggcaaagc ggcctgaaaa acacctctgt catgatggtg     2040

gatctactcg ctcacacaaa ctataccttt gagattgagg cagtgaatgg agtgtccgac     2100

ttgagcccag gagcccggca gtatgtgtct gtaaatgtaa ccacaaatca agcagctcca     2160

tctccagtca ccaatgtgaa aaaagggaaa attgcaaaaa acagcatctc tttgtcttgg     2220

caagaaccag atcgtcccaa tggaatcatc ctagagtatg aaatcaagta ttttgaaaag     2280

gaccaagaga ccagctacac gattatcaaa tctaaagaga caactattac tgcagagggc     2340

ttgaaaccag cttcagttta tgtcttccaa attcgagcac gtacagcagc aggctatggt     2400

gtcttcagtc gaagatttga gtttgaaacc accccagtgt ttgcagcatc cagcgatcaa     2460

agccagattc ctgtaattgc tgtgtctgtg acagtgggag tcattttgtt ggcagtggtt     2520

atcggcgtcc tcctcagtgg aagttgctgc gaatgtggct gtgggagggc ttcttccctg     2580

tgcgctgttg cccatccaag cctaatatgg cggtgtggct acagcaaagc aaaacaagat     2640

ccagaagagg aaaagatgca ttttcataat gggcacatta aactgccagg agtaagaact     2700

tacattgatc cacataccta tgaggatccc aatcaagctg tccacgaatt tgctaaggag     2760

atagaagcat catgtatcac cattgagaga gttattggag caggtgaatt tggtgaagtt     2820

tgtagtggac gtttgaaact accaggaaaa agagaattac ctgtggctat caaaaccctt     2880

aaagtaggct atactgaaaa gcaacgcaga gatttcctag gtgaagcaag tatcatggga     2940

cagtttgatc atcctaacat catccattta gaaggtgtgg tgaccaaaag taaaccagtg     3000

atgatcgtga cagagtatat ggagaatggc tctttagata catttttgaa gaaaaacgat     3060

gggcagttca ctgtgattca gcttgttggc atgctgagag gtatctctgc aggaatgaag     3120

tacctttctg acatgggcta tgtgcataga gatcttgctg ccagaaacat cttaatcaac     3180

agtaaccttg tgtgcaaagt gtctgacttt ggactttccc gggtactgga agatgatccc     3240

gaggcagcct acaccacaag gggaggaaaa attccaatca gatggactgc cccagaagca     3300

atagctttcc gaaagtttac ttctgccagt gatgtctgga gttatggaat agtaatgtgg     3360

gaagttgtgt cttatggaga gagaccctac tgggagatga ccaatcaaga tgtgattaaa     3420

gcggtagagg aaggctatcg tctgccaagc cccatggatt gtcctgctgc tctctatcag     3480

ttaatgctgg attgctggca gaaagagcga aatagcaggc ccaagtttga tgaaatagtc     3540

aacatgttgg acaagctgat acgtaaccca agtagtctga agacgctggt taatgcatcc     3600

tgcagagtat ctaatttatt ggcagaacat agcccactag gatctggggc ctacagatca     3660

gtaggtgaat ggctagaggc aatcaagatg ggccggtata cagagatttt catggaaaat     3720

ggatacagtt caatggacgc tgtggctcag gtgaccttgg aggatttgag acggcttgga     3780

gtgactcttg tcggtcacca gaagaagatc atgaacagcc ttcaagaaat gaaggtgcag     3840

ctggtaaacg gaatggtgcc attgtaactt catgtaaatg tcgcttcttc aagtgaatga     3900

ttctgcactt tgtaaacagc actgagattt attttaacaa aaaaaggggg aaaagggaaa     3960

acagtgattt ctaaacctta gaaaacattt gcctcagcca cagaatttgt aatcatggtt     4020

ttactgaagt atccagttct tagtccttag tcttcatttt tcatgaagca aacatatctt     4080

gcattaaaag ggacatgaag ttagacatca tcttaagtta caacaacaga atccttccca     4140

ctacttctac aaaattttgt acatgaaata tataattata tagcactttt atagactgaa     4200

ttaaggcaac ccctttcaaa acttccaggg atctacttga aaggaaatgt tttatagcca     4260

tttgtgagct aacaaaagct acagtttact gaagtttact tcaagtctta attgtctaca     4320

aaagtgtatt gaagagcaat atgattagat tatttcttaa tagatatctt cttttgtaat     4380

tttaaaatgc tgttacacag cgttaagtta tagaaactag tgtgtaaaca tgttgcttga     4440

tcaagaaaaa gtacaataca gggtgtatat ttattttttg tgttataaag tttactttta     4500

gttgctcttc tagagattat taggtaataa atgtgtatat actgtataat ttgcaatata     4560

cccaggaact gatttaagat ggaattgtgt gtgtgtttgc ttgcacatgt gtgtgttacc     4620

attctgcttg catttctaat agtgtttcaa ttttagcaac atataggagc aagtgttcca     4680

gaatgtaata tgaataggag aaatagggaa gcagtaaaac aaaatttaac acaagcttgt     4740

gtctcttttc ctctcatgtg tccaaaagct aatctcttta ttcactaaaa ggaaatgtgt     4800

ataagactaa atcccctttg gctttttaaa aacattttgt gatatcagtg acaatgcagt     4860

tcttctagcc attaatcttg tacccctgta agaaatttca cctttctgag tcctgaaaag     4920

tatcttgtca agcaaagttg acaccgaagg gcacattttc agcaggatgt agaaggattt     4980

aactgtgcag gcttctgtta atgttgttaa atccaggcac atagcacgaa gcatcaccct     5040

taagtgttaa tccgttgtaa ccattcccat tttgactcag ttctagaaat tttgactcta     5100

aggcagcaat ggaattatga caaatatata tatatacaca tacacacaca caaatatata     5160

tatatgctta tttcccttca gaattttatt tcaataattg ataagtttta tttttaatgg     5220

atgtttattc atttgttaat ttcagtttgt attcagttac atggctttga gtttatttta     5280

ttgaaccaat ccaaggtatt atgtaattag gcttattaag gaatataaca tatcttctat     5340

gtatgctcta tataccacac atgatgaaga cttatatttg tgatacaaat tatgcagtgt     5400

attagaaatt gtccaaaact gagctcctga gataaccaac atttttgtat tattacactt     5460

tataaaaatt atggaatgtc atgtgattag tcaaaatcag agcatttaaa taaaatacag     5520

cctactcatg attatcaatg ttaatagtac agtagatcag agaagcctgg attaatgaaa     5580

tttatcagaa atatagccac gttatattaa tggtattctt ttttccaagc acttgtttta     5640

tttgaatatt agcacatata agaataaact tttgggaaat aactacttcc tattctgccc     5700

accctttact taagcagtaa agtacctctt ttctaaagaa ccaggaaaca tcaaaataac     5760

cacaacaaaa atctaaacag ttttcaaata atacattcag ttctcataat aataagggct     5820

atataccatg ggtccacaca aactgtgctg caaacatata atctattagt ttagtaaaat     5880

ttccagagat gtgaatttaa tattttcttg ataaaatcat aaaaaagcat caccattatt     5940

aaagatgcat ttgttcattt caataaacag aaattaatga aacaaattac ttttgtacaa     6000

aataaatgat gattatgtgg cactttattg aattttatag aaatattcca atctaagtga     6060

taaagtaaca actgagaaac ttcagaatga aagccttatt gattcaaaag gaaaattacc     6120

atatgcttta gggctgatga acttgccaca attgcttaga cataacaaag atattttcta     6180

cattgttttc caactttata tgctgaaaga taattaggag gtccgggtgg agtgtatcta     6240

aatgactaga actttaagtt gcaatataga ttttctcttt ttaacaaagg aagaatataa     6300

attaatttgg atcaaattta tttgccttct ttgcaatctt ggtgatcatt ttggaaagta     6360

aattgaaagg aaagttaaat agccacatag ttttcttttg catctcaatt tggttgagaa     6420

tttctaagga aggttaatat gactttagaa tgaataaaga gactgtcaaa caacaagtac     6480

tctccctaaa aaagaggaaa gaatgccttc ctaaaatatt tgtttcctat tgtatatgtc     6540

accaattgga aaatgccaat ctcatctgca agtgtgagaa atggaacaag gagaggagcc     6600

aactctagta aaatgtagtg aggccataat ccaaggcaaa gtttaacaaa tcttgattgt     6660

gtaatttctt attctgttga ttcattttgt cacccaccag actaccaaaa ataaagcaca     6720

gacatgacaa ttttagtata tacaacagat ttggcaaata atacataatc ttattgtaat     6780

tgccagtagc aatatcttaa ggggcatgag tctttcacag tattggactt tgaaaaattg     6840

gtacagggag taattttcaa cagactgata cttgaagtca ctcaattact actttgacct     6900

atcataattt gtttctaatc ttgtcatttg ctcatatata ctattaatat aaccagttgc     6960

tcttttcata atgtactatt tctatgtaaa gatgtaaaga ttttgatttt cctatgtttt     7020

aaaattgtaa tgtgcatgat cttttatttc ttgtgtttca attaccaagt cagtattcta     7080

aggttgtaag attactgtaa aaattatatt ccaatatttt atctaaactt aagtgtggcc     7140

agcattattg gtttcagagt tgcctaaaca acacagaata tccttaattc agtttgtaaa     7200

agagttttga ccagtgtaaa aaagtgaaga cacagtttca tgtttcaagt ttaaaatgga     7260

aagttaatat catttgagca cttatgtgtt ttcatgtctt ctacttaatc tgtatgtgaa     7320

agtaaaatat ttttaacacc attatttatg ccatgtaaag tgggttctca gaagcacaag     7380

cacagatatt taccttctga agacattttt ggctataaaa gtgcattgga tggcaaacac     7440

tatttgagtc aggtgttaga aatttattag atgtattata ttacatagta gaataaggtc     7500

cctttctcat tttgtttttc ctaaaaataa gaaaaaaaag aagtgtgata gtaaactgtc     7560

tttgctaatg tcctgccaga tgtttaactt caaattaagc aaaaagtagg tacaatatga     7620

tgatgatcct gatgatgatg atgatgatga tgatgaagaa taaatggaat caaaatgcta     7680

gctttatttg acattaataa gtaaaataag tcatcatttt ttcaactctg tagcacagct     7740

gtttacattg aataattttc tctattgtgc tgttaattat atagtaatgt atcaaaatag     7800

aaataggaac tttcttttca tttcttattc atttatgaag aaatcttttc acacataaat     7860

gattgaatgt tcttgttcag aatgaccaca taatcattgc ttagaagaag ataccaattc     7920

ttttaaaaga aaaaaagtct gtttataata atcagaatca aatgttgttt gtttcttcta     7980

aacgttaatg gagaaaattg aaggtggtaa aatgtcatgt ttattcaggc tgggaactgt     8040

attcacagta gaagtttcag tggtcaacat atctatgact ctttaggctg ctgtagtttt     8100

acagtcaatt atttaaaagt gagtagttac atttataaga gcctgagaat acttagactc     8160

agtcatttgt tagtattttt accaaaatct cttagtttca gacatgtcag aagcagctat     8220

atagcatatc ttattctatg atatacatca ggctatctca agttcctgtc tcacagttaa     8280

ttcaaagaag gattaggatt tctgtatttt ttctcatttg aatctttatg tgcatttggt     8340

ttgtgtacat gctttttgta gtgtaagata tgaaatttta tattttttca gaaaataaaa     8400

accctttgaa tacagttaaa aaaaaaaaaa aaaaa                                8435


<210>  43
<211>  1016
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  43

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly Arg Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Ser Val Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile 
                565                 570                 575     


Ala Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly 
            580                 585                 590         


Val Leu Leu Ser Gly Arg Arg Cys Gly Tyr Ser Lys Ala Lys Gln Asp 
        595                 600                 605             


Pro Glu Glu Glu Lys Met His Phe His Asn Gly His Ile Lys Leu Pro 
    610                 615                 620                 


Gly Val Arg Thr Tyr Ile Asp Pro His Thr Tyr Glu Asp Pro Asn Gln 
625                 630                 635                 640 


Ala Val His Glu Phe Ala Lys Glu Ile Glu Ala Ser Cys Ile Thr Ile 
                645                 650                 655     


Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg 
            660                 665                 670         


Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro Val Ala Ile Lys Thr Leu 
        675                 680                 685             


Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala 
    690                 695                 700                 


Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly 
705                 710                 715                 720 


Val Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu 
                725                 730                 735     


Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn Asp Gly Gln Phe Thr 
            740                 745                 750         


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ser Ala Gly Met Lys 
        755                 760                 765             


Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
    770                 775                 780                 


Ile Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
785                 790                 795                 800 


Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly 
                805                 810                 815     


Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg 
            820                 825                 830         


Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp 
        835                 840                 845             


Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Thr Asn Gln 
    850                 855                 860                 


Asp Val Ile Lys Ala Val Glu Glu Gly Tyr Arg Leu Pro Ser Pro Met 
865                 870                 875                 880 


Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys 
                885                 890                 895     


Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile Val Asn Met Leu Asp 
            900                 905                 910         


Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr Leu Val Asn Ala Ser 
        915                 920                 925             


Cys Arg Val Ser Asn Leu Leu Ala Glu His Ser Pro Leu Gly Ser Gly 
    930                 935                 940                 


Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala Ile Lys Met Gly Arg 
945                 950                 955                 960 


Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser Ser Met Asp Ala Val 
                965                 970                 975     


Ala Gln Val Thr Leu Glu Asp Leu Arg Arg Leu Gly Val Thr Leu Val 
            980                 985                 990         


Gly His Gln Lys Lys Ile Met Asn  Ser Leu Gln Glu Met  Lys Val Gln 
        995                 1000                 1005             


Leu Val  Asn Gly Met Val Pro  Leu 
    1010                 1015     


<210>  44
<211>  3004
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  44
acatttctgc agccgcgcgg cgagccattc gcggcggctg ctgcagctcc tactgcatct       60

tccttctctt cctttcctcg ggctccggtc tcggagtcgg agagcgcgcc tcgcttccag      120

agcccccgga cccggcgagt cagcgatcgc cgagccggcc accatgcccg gcagaccgcg      180

ccactaggcg ctcctcgcgg ctcccacccg gcggcggcgg cggcggcggc ggcgtccgcg      240

atggtttcag acgctgaagg attttgcatc tgatcgctcg gcgtttcaaa gaagcagcga      300

tcggagatgg atgtctctct ttgcccagcc aagtgtagtt tctggcggat tttcttgctg      360

ggaagcgtct ggctggacta tgtgggctcc gtgctggctt gccctgcaaa ttgtgtctgc      420

agcaagactg agatcaattg ccggcggccg gacgatggga acctcttccc cctcctggaa      480

gggcaggatt cagggaacag caatgggaac gccagtatca acatcacgga catctcaagg      540

aatatcactt ccatacacat agagaactgg cgcagtcttc acacgctcaa cgccgtggac      600

atggagctct acaccggact tcaaaagctg accatcaaga actcaggact tcggagcatt      660

cagcccagag cctttgccaa gaacccccat ttgcgttata taaacctgtc aagtaaccgg      720

ctcaccacac tctcgtggca gctcttccag acgctgagtc ttcgggaatt gcagttggag      780

cagaactttt tcaactgcag ctgtgacatc cgctggatgc agctctggca ggagcagggg      840

gaggccaagc tcaacagcca gaacctctac tgcatcaacg ctgatggctc ccagcttcct      900

ctcttccgca tgaacatcag tcagtgtgac cttcctgaga tcagcgtgag ccacgtcaac      960

ctgaccgtac gagagggtga caatgctgtt atcacttgca atggctctgg atcacccctt     1020

cctgatgtgg actggatagt cactgggctg cagtccatca acactcacca gaccaatctg     1080

aactggacca atgttcatgc catcaacttg acgctggtga atgtgacgag tgaggacaat     1140

ggcttcaccc tgacgtgcat tgcagagaac gtggtgggca tgagcaatgc cagtgttgcc     1200

ctcactgtct actatccccc acgtgtggtg agcctggagg agcctgagct gcgcctggag     1260

cactgcatcg agtttgtggt gcgtggcaac cccccaccaa cgctgcactg gctgcacaat     1320

gggcagcctc tgcgggagtc caagatcatc catgtggaat actaccaaga gggagagatt     1380

tccgagggct gcctgctctt caacaagccc acccactaca acaatggcaa ctataccctc     1440

attgccaaaa acccactggg cacagccaac cagaccatca atggccactt cctcaaggag     1500

ccctttccag agagcacgga taactttatc ttgtttgacg aagtgagtcc cacacctcct     1560

atcactgtga cccacaaacc agaagaagac acttttgggg tatccatagc agttggactt     1620

gctgcttttg cctgtgtcct gttggtggtt ctcttcgtca tgatcaacaa atatggtcga     1680

cggtccaaat ttggaatgaa gggtcccgtg gctgtcatca gtggtgagga ggactcagcc     1740

agcccactgc accacatcaa ccacggcatc accacgccct cgtcactgga tgccgggccc     1800

gacactgtgg tcattggcat gactcgcatc cctgtcattg agaaccccca gtacttccgt     1860

cagggacaca actgccacaa gccggacacg tatgtgcagc acattaagag gagagacatc     1920

gtgctgaagc gagaactggg tgagggagcc tttggaaagg tcttcctggc cgagtgctac     1980

aacctcagcc cgaccaagga caagatgctt gtggctgtga aggccctgaa ggatcccacc     2040

ctggctgccc ggaaggattt ccagagggag gccgagctgc tcaccaacct gcagcatgag     2100

cacattgtca agttctatgg agtgtgcggc gatggggacc ccctcatcat ggtctttgaa     2160

tacatgaagc atggagacct gaataagttc ctcagggccc atgggccaga tgcaatgatc     2220

cttgtggatg gacagccacg ccaggccaag ggtgagctgg ggctctccca aatgctccac     2280

attgccagtc agatcgcctc gggtatggtg tacctggcct cccagcactt tgtgcaccga     2340

gacctggcca ccaggaactg cctggttgga gcgaatctgc tagtgaagat tggggacttc     2400

ggcatgtcca gagatgtcta cagcacggat tattacaggc tctttaatcc atctggaaat     2460

gatttttgta tatggtgtga ggtgggagga cacaccatgc tccccattcg ctggatgcct     2520

cctgaaagca tcatgtaccg gaagttcact acagagagtg atgtatggag cttcggggtg     2580

atcctctggg agatcttcac ctatggaaag cagccatggt tccaactctc aaacacggag     2640

gtcattgagt gcattaccca aggtcgtgtt ttggagcggc cccgagtctg ccccaaagag     2700

gtgtacgatg tcatgctggg gtgctggcag agggaaccac agcagcggtt gaacatcaag     2760

gagatctaca aaatcctcca tgctttgggg aaggccaccc caatctacct ggacattctt     2820

ggctagtggt ggctggtggt catgaattca tactctgttg cctcctctct ccctgcctca     2880

catctccctt ccacctcaca actccttcca tccttgactg aagcgaacat cttcatataa     2940

actcaagtgc ctgctacaca tacaacactg aaaaaaggaa aaaaaaagaa agaaaaaaaa     3000

accc                                                                  3004


<210>  45
<211>  612
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  45

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp 
    530                 535                 540                 


Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro 
545                 550                 555                 560 


Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg 
                565                 570                 575     


Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu 
            580                 585                 590         


Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly 
        595                 600                 605             


Arg His Gly Phe 
    610         


<210>  46
<211>  10070
<212>  DNA
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  HUMAN SYNTHETIC PROMOTER

<400>  46
gcggagagaa ccctctgttt tcccccactc tctctccacc tcctcctgcc ttccccaccc       60

cgagtgcgga gccagagatc aaaagatgaa aaggcagtca ggtcttcagt agccaaaaaa      120

caaaacaaac aaaaacaaaa aagccgaaat aaaagaaaaa gataataact cagttcttat      180

ttgcacctac ttcagtggac actgaatttg gaaggtggag gattttgttt ttttctttta      240

agatctgggc atcttttgaa tctacccttc aagtattaag agacagactg tgagcctagc      300

agggcagatc ttgtccaccg tgtgtcttct tctgcacgag actttgaggc tgtcagagcg      360

ctttttgcgt ggttgctccc gcaagtttcc ttctctggag cttcccgcag gtgggcagct      420

agctgcagcg actaccgcat catcacagcc tgttgaactc ttctgagcaa gagaagggga      480

ggcggggtaa gggaagtagg tggaagattc agccaagctc aaggatggaa gtgcagttag      540

ggctgggaag ggtctaccct cggccgccgt ccaagaccta ccgaggagct ttccagaatc      600

tgttccagag cgtgcgcgaa gtgatccaga acccgggccc caggcaccca gaggccgcga      660

gcgcagcacc tcccggcgcc agtttgctgc tgctgcagca gcagcagcag cagcagcagc      720

agcagcagca gcagcagcag cagcagcagc agcagcagca gcaagagact agccccaggc      780

agcagcagca gcagcagggt gaggatggtt ctccccaagc ccatcgtaga ggccccacag      840

gctacctggt cctggatgag gaacagcaac cttcacagcc gcagtcggcc ctggagtgcc      900

accccgagag aggttgcgtc ccagagcctg gagccgccgt ggccgccagc aaggggctgc      960

cgcagcagct gccagcacct ccggacgagg atgactcagc tgccccatcc acgttgtccc     1020

tgctgggccc cactttcccc ggcttaagca gctgctccgc tgaccttaaa gacatcctga     1080

gcgaggccag caccatgcaa ctccttcagc aacagcagca ggaagcagta tccgaaggca     1140

gcagcagcgg gagagcgagg gaggcctcgg gggctcccac ttcctccaag gacaattact     1200

tagggggcac ttcgaccatt tctgacaacg ccaaggagtt gtgtaaggca gtgtcggtgt     1260

ccatgggcct gggtgtggag gcgttggagc atctgagtcc aggggaacag cttcgggggg     1320

attgcatgta cgccccactt ttgggagttc cacccgctgt gcgtcccact ccttgtgccc     1380

cattggccga atgcaaaggt tctctgctag acgacagcgc aggcaagagc actgaagata     1440

ctgctgagta ttcccctttc aagggaggtt acaccaaagg gctagaaggc gagagcctag     1500

gctgctctgg cagcgctgca gcagggagct ccgggacact tgaactgccg tctaccctgt     1560

ctctctacaa gtccggagca ctggacgagg cagctgcgta ccagagtcgc gactactaca     1620

actttccact ggctctggcc ggaccgccgc cccctccgcc gcctccccat ccccacgctc     1680

gcatcaagct ggagaacccg ctggactacg gcagcgcctg ggcggctgcg gcggcgcagt     1740

gccgctatgg ggacctggcg agcctgcatg gcgcgggtgc agcgggaccc ggttctgggt     1800

caccctcagc cgccgcttcc tcatcctggc acactctctt cacagccgaa gaaggccagt     1860

tgtatggacc gtgtggtggt ggtgggggtg gtggcggcgg cggcggcggc ggcggcggcg     1920

gcggcggcgg cggcggcggc ggcgaggcgg gagctgtagc cccctacggc tacactcggc     1980

cccctcaggg gctggcgggc caggaaagcg acttcaccgc acctgatgtg tggtaccctg     2040

gcggcatggt gagcagagtg ccctatccca gtcccacttg tgtcaaaagc gaaatgggcc     2100

cctggatgga tagctactcc ggaccttacg gggacatgcg tttggagact gccagggacc     2160

atgttttgcc cattgactat tactttccac cccagaagac ctgcctgatc tgtggagatg     2220

aagcttctgg gtgtcactat ggagctctca catgtggaag ctgcaaggtc ttcttcaaaa     2280

gagccgctga agggaaacag aagtacctgt gcgccagcag aaatgattgc actattgata     2340

aattccgaag gaaaaattgt ccatcttgtc gtcttcggaa atgttatgaa gcagggatga     2400

ctctgggagc ccggaagctg aagaaacttg gtaatctgaa actacaggag gaaggagagg     2460

cttccagcac caccagcccc actgaggaga caacccagaa gctgacagtg tcacacattg     2520

aaggctatga atgtcagccc atctttctga atgtcctgga agccattgag ccaggtgtag     2580

tgtgtgctgg acacgacaac aaccagcccg actcctttgc agccttgctc tctagcctca     2640

atgaactggg agagagacag cttgtacacg tggtcaagtg ggccaaggcc ttgcctggct     2700

tccgcaactt acacgtggac gaccagatgg ctgtcattca gtactcctgg atggggctca     2760

tggtgtttgc catgggctgg cgatccttca ccaatgtcaa ctccaggatg ctctacttcg     2820

cccctgatct ggttttcaat gagtaccgca tgcacaagtc ccggatgtac agccagtgtg     2880

tccgaatgag gcacctctct caagagtttg gatggctcca aatcaccccc caggaattcc     2940

tgtgcatgaa agcactgcta ctcttcagca ttattccagt ggatgggctg aaaaatcaaa     3000

aattctttga tgaacttcga atgaactaca tcaaggaact cgatcgtatc attgcatgca     3060

aaagaaaaaa tcccacatcc tgctcaagac gcttctacca gctcaccaag ctcctggact     3120

ccgtgcagcc tattgcgaga gagctgcatc agttcacttt tgacctgcta atcaagtcac     3180

acatggtgag cgtggacttt ccggaaatga tggcagagat catctctgtg caagtgccca     3240

agatcctttc tgggaaagtc aagcccatct atttccacac ccagtgaagc attggaaacc     3300

ctatttcccc accccagctc atgccccctt tcagatgtct tctgcctgtt ataactctgc     3360

actactcctc tgcagtgcct tggggaattt cctctattga tgtacagtct gtcatgaaca     3420

tgttcctgaa ttctatttgc tgggcttttt ttttctcttt ctctcctttc tttttcttct     3480

tccctcccta tctaaccctc ccatggcacc ttcagacttt gcttcccatt gtggctccta     3540

tctgtgtttt gaatggtgtt gtatgccttt aaatctgtga tgatcctcat atggcccagt     3600

gtcaagttgt gcttgtttac agcactactc tgtgccagcc acacaaacgt ttacttatct     3660

tatgccacgg gaagtttaga gagctaagat tatctgggga aatcaaaaca aaaacaagca     3720

aacaaaaaaa aaaagcaaaa acaaaacaaa aaataagcca aaaaaccttg ctagtgtttt     3780

ttcctcaaaa ataaataaat aaataaataa atacgtacat acatacacac atacatacaa     3840

acatatagaa atccccaaag aggccaatag tgacgagaag gtgaaaattg caggcccatg     3900

gggagttact gattttttca tctcctccct ccacgggaga ctttattttc tgccaatggc     3960

tattgccatt agagggcaga gtgaccccag agctgagttg ggcagggggg tggacagaga     4020

ggagaggaca aggagggcaa tggagcatca gtacctgccc acagccttgg tccctggggg     4080

ctagactgct caactgtgga gcaattcatt atactgaaaa tgtgcttgtt gttgaaaatt     4140

tgtctgcatg ttaatgcctc acccccaaac ccttttctct ctcactctct gcctccaact     4200

tcagattgac tttcaatagt ttttctaaga cctttgaact gaatgttctc ttcagccaaa     4260

acttggcgac ttccacagaa aagtctgacc actgagaaga aggagagcag agatttaacc     4320

ctttgtaagg ccccatttgg atccaggtct gctttctcat gtgtgagtca gggaggagct     4380

ggagccagag gagaagaaaa tgatagcttg gctgttctcc tgcttaggac actgactgaa     4440

tagttaaact ctcactgcca ctaccttttc cccaccttta aaagacctga atgaagtttt     4500

ctgccaaact ccgtgaagcc acaagcacct tatgtcctcc cttcagtgtt ttgtgggcct     4560

gaatttcatc acactgcatt tcagccatgg tcatcaagcc tgtttgcttc ttttgggcat     4620

gttcacagat tctctgttaa gagcccccac caccaagaag gttagcaggc caacagctct     4680

gacatctatc tgtagatgcc agtagtcaca aagatttctt accaactctc agatcgctgg     4740

agcccttaga caaactggaa agaaggcatc aaagggatca ggcaagctgg gcgtcttgcc     4800

cttgtccccc agagatgata ccctcccagc aagtggagaa gttctcactt ccttctttag     4860

agcagctaaa ggggctaccc agatcagggt tgaagagaaa actcaattac cagggtggga     4920

agaatgaagg cactagaacc agaaaccctg caaatgctct tcttgtcacc cagcatatcc     4980

acctgcagaa gtcatgagaa gagagaagga acaaagagga gactctgact actgaattaa     5040

aatcttcagc ggcaaagcct aaagccagat ggacaccatc tggtgagttt actcatcatc     5100

ctcctctgct gctgattctg ggctctgaca ttgcccatac tcactcagat tccccacctt     5160

tgttgctgcc tcttagtcag agggaggcca aaccattgag actttctaca gaaccatggc     5220

ttctttcgga aaggtctggt tggtgtggct ccaatacttt gccacccatg aactcagggt     5280

gtgccctggg acactggttt tatatagtct tttggcacac ctgtgttctg ttgacttcgt     5340

tcttcaagcc caagtgcaag ggaaaatgtc cacctacttt ctcatcttgg cctctgcctc     5400

cttacttagc tcttaatctc atctgttgaa ctcaagaaat caagggccag tcatcaagct     5460

gcccatttta attgattcac tctgtttgtt gagaggatag tttctgagtg acatgatatg     5520

atccacaagg gtttccttcc ctgatttctg cattgatatt aatagccaaa cgaacttcaa     5580

aacagcttta aataacaagg gagaggggaa cctaagatga gtaatatgcc aatccaagac     5640

tgctggagaa aactaaagct gacaggttcc ctttttgggg tgggatagac atgttctggt     5700

tttctttatt attacacaat ctggctcatg tacaggatca cttttagctg ttttaaacag     5760

aaaaaaatat ccaccactct tttcagttac actaggttac attttaatag gtcctttaca     5820

tctgttttgg aatgattttc atcttttgtg atacacagat tgaattatat cattttcata     5880

tctctccttg taaatactag aagctctcct ttacatttct ctatcaaatt tttcatcttt     5940

atgggtttcc caattgtgac tcttgtcttc atgaatatat gtttttcatt tgcaaaagcc     6000

aaaaatcagt gaaacagcag tgtaattaaa agcaacaact ggattactcc aaatttccaa     6060

atgacaaaac tagggaaaaa tagcctacac aagcctttag gcctactctt tctgtgcttg     6120

ggtttgagtg aacaaaggag attttagctt ggctctgttc tcccatggat gaaaggagga     6180

ggattttttt tttcttttgg ccattgatgt tctagccaat gtaattgaca gaagtctcat     6240

tttgcatgcg ctctgctcta caaacagagt tggtatggtt ggtatactgt actcacctgt     6300

gagggactgg ccactcagac ccacttagct ggtgagctag aagatgagga tcactcactg     6360

gaaaagtcac aaggaccatc tccaaacaag ttggcagtgc tcgatgtgga cgaagagtga     6420

ggaagagaaa aagaaggagc accagggaga aggctccgtc tgtgctgggc agcagacagc     6480

tgccaggatc acgaactctg tagtcaaaga aaagagtcgt gtggcagttt cagctctcgt     6540

tcattgggca gctcgcctag gcccagcctc tgagctgaca tgggagttgt tggattcttt     6600

gtttcatagc tttttctatg ccataggcaa tattgttgtt cttggaaagt ttattatttt     6660

tttaactccc ttactctgag aaagggatat tttgaaggac tgtcatatat ctttgaaaaa     6720

agaaaatctg taatacatat atttttatgt atgttcactg gcactaaaaa atatagagag     6780

cttcattctg tcctttgggt agttgctgag gtaattgtcc aggttgaaaa ataatgtgct     6840

gatgctagag tccctctctg tccatactct acttctaaat acatataggc atacatagca     6900

agttttattt gacttgtact ttaagagaaa atatgtccac catccacatg atgcacaaat     6960

gagctaacat tgagcttcaa gtagcttcta agtgtttgtt tcattaggca cagcacagat     7020

gtggcctttc cccccttctc tcccttgata tctggcaggg cataaaggcc caggccactt     7080

cctctgcccc ttcccagccc tgcaccaaag ctgcatttca ggagactctc tccagacagc     7140

ccagtaacta cccgagcatg gcccctgcat agccctggaa aaataagagg ctgactgtct     7200

acgaattatc ttgtgccagt tgcccaggtg agagggcact gggccaaggg agtggttttc     7260

atgtttgacc cactacaagg ggtcatggga atcaggaatg ccaaagcacc agatcaaatc     7320

caaaacttaa agtcaaaata agccattcag catgttcagt ttcttggaaa aggaagtttc     7380

tacccctgat gcctttgtag gcagatctgt tctcaccatt aatctttttg aaaatctttt     7440

aaagcagttt ttaaaaagag agatgaaagc atcacattat ataaccaaag attacattgt     7500

acctgctaag ataccaaaat tcataagggc agggggggag caagcattag tgcctctttg     7560

ataagctgtc caaagacaga ctaaaggact ctgctggtga ctgacttata agagctttgt     7620

gggttttttt ttccctaata atatacatgt ttagaagaat tgaaaataat ttcgggaaaa     7680

tgggattatg ggtccttcac taagtgattt tataagcaga actggctttc cttttctcta     7740

gtagttgctg agcaaattgt tgaagctcca tcattgcatg gttggaaatg gagctgttct     7800

tagccactgt gtttgctagt gcccatgtta gcttatctga agatgtgaaa cccttgctga     7860

taagggagca tttaaagtac tagattttgc actagaggga cagcaggcag aaatccttat     7920

ttctgcccac tttggatggc acaaaaagtt atctgcagtt gaaggcagaa agttgaaata     7980

cattgtaaat gaatatttgt atccatgttt caaaattgaa atatatatat atatatatat     8040

atatatatat atatatatat agtgtgtgtg tgtgttctga tagctttaac tttctctgca     8100

tctttatatt tggttccaga tcacacctga tgccatgtac ttgtgagaga ggatgcagtt     8160

ttgttttgga agctctctca gaacaaacaa gacacctgga ttgatcagtt aactaaaagt     8220

tttctcccct attgggtttg acccacaggt cctgtgaagg agcagaggga taaaaagagt     8280

agaggacatg atacattgta ctttactagt tcaagacaga tgaatgtgga aagcataaaa     8340

actcaatgga actgactgag atttaccaca gggaaggccc aaacttgggg ccaaaagcct     8400

acccaagtga ttgaccagtg gccccctaat gggacctgag ctgttggaag aagagaactg     8460

ttccttggtc ttcaccatcc ttgtgagaga agggcagttt cctgcattgg aacctggagc     8520

aagcgctcta tctttcacac aaattccctc acctgagatt gaggtgctct tgttactggg     8580

tgtctgtgtg ctgtaattct ggttttggat atgttctgta aagattttga caaatgaaaa     8640

tgtgtttttc tctgttaaaa cttgtcagag tactagaagt tgtatctctg taggtgcagg     8700

tccatttctg cccacaggta gggtgttttt ctttgattaa gagattgaca cttctgttgc     8760

ctaggacctc ccaactcaac catttctagg tgaaggcaga aaaatccaca ttagttactc     8820

ctcttcagac atttcagctg agataacaaa tcttttggaa ttttttcacc catagaaaga     8880

gtggtagata tttgaattta gcaggtggag tttcatagta aaaacagctt ttgactcagc     8940

tttgatttat cctcatttga tttggccaga aagtaggtaa tatgcattga ttggcttctg     9000

attccaattc agtatagcaa ggtgctaggt tttttccttt ccccacctgt ctcttagcct     9060

ggggaattaa atgagaagcc ttagaatggg tggcccttgt gacctgaaac acttcccaca     9120

taagctactt aacaagattg tcatggagct gcagattcca ttgcccacca aagactagaa     9180

cacacacata tccatacacc aaaggaaaga caattctgaa atgctgtttc tctggtggtt     9240

ccctctctgg ctgctgcctc acagtatggg aacctgtact ctgcagaggt gacaggccag     9300

atttgcatta tctcacaacc ttagcccttg gtgctaactg tcctacagtg aagtgcctgg     9360

ggggttgtcc tatcccataa gccacttgga tgctgacagc agccaccatc agaatgaccc     9420

acgcaaaaaa aagaaaaaaa aaattaaaaa gtcccctcac aacccagtga cacctttctg     9480

ctttcctcta gactggaaca ttgattaggg agtgcctcag acatgacatt cttgtgctgt     9540

ccttggaatt aatctggcag caggagggag cagactatgt aaacagagat aaaaattaat     9600

tttcaatatt gaaggaaaaa agaaataaga agagagagag aaagaaagca tcacacaaag     9660

attttcttaa aagaaacaat tttgcttgaa atctctttag atggggctca tttctcacgg     9720

tggcacttgg cctccactgg gcagcaggac cagctccaag cgctagtgtt ctgttctctt     9780

tttgtaatct tggaatcttt tgttgctcta aatacaatta aaaatggcag aaacttgttt     9840

gttggactac atgtgtgact ttgggtctgt ctctgcctct gctttcagaa atgtcatcca     9900

ttgtgtaaaa tattggctta ctggtctgcc agctaaaact tggccacatc ccctgttatg     9960

gctgcaggat cgagttattg ttaacaaaga gacccaagaa aagctgctaa tgtcctctta    10020

tcattgttgt taatttgtta aaacataaag aaatctaaaa tttcaaaaaa               10070


<210>  47
<211>  917
<212>  PRT
<213>  Artificial Sequence/Human Synthetic Promoter

<220>
<223>  Human synthetic promoter

<400>  47

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr Ser 
65                  70                  75                  80  


Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln Ala 
                85                  90                  95      


His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln Gln 
            100                 105                 110         


Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly Cys 
        115                 120                 125             


Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro Gln 
    130                 135                 140                 


Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser Thr 
145                 150                 155                 160 


Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala 
                165                 170                 175     


Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu Gln 
            180                 185                 190         


Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg Ala 
        195                 200                 205             


Arg Glu Arg Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu Gly 
    210                 215                 220                 


Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala Val 
225                 230                 235                 240 


Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro 
                245                 250                 255     


Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly Val 
            260                 265                 270         


Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys Lys 
        275                 280                 285             


Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr Ala 
    290                 295                 300                 


Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly Glu 
305                 310                 315                 320 


Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr Leu 
                325                 330                 335     


Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp Glu 
            340                 345                 350         


Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu 
        355                 360                 365             


Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg Ile 
    370                 375                 380                 


Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly Ala 
                405                 410                 415     


Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser Trp 
            420                 425                 430         


His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr 
465                 470                 475                 480 


Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe Thr Ala 
                485                 490                 495     


Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro Tyr Pro 
            500                 505                 510         


Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp Ser Tyr 
        515                 520                 525             


Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp His Val 
    530                 535                 540                 


Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys 
545                 550                 555                 560 


Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser 
                565                 570                 575     


Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu 
            580                 585                 590         


Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn 
        595                 600                 605             


Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu 
    610                 615                 620                 


Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu 
625                 630                 635                 640 


Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys 
                645                 650                 655     


Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu 
            660                 665                 670         


Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp 
        675                 680                 685             


Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu 
    690                 695                 700                 


Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu 
705                 710                 715                 720 


Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln 
                725                 730                 735     


Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe 
            740                 745                 750         


Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe 
        755                 760                 765             


Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg 
    770                 775                 780                 


Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln 
785                 790                 795                 800 


Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val 
                805                 810                 815     


Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr 
            820                 825                 830         


Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr 
        835                 840                 845             


Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val 
    850                 855                 860                 


Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile 
865                 870                 875                 880 


Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile 
                885                 890                 895     


Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile 
            900                 905                 910         


Tyr Phe His Thr Gln 
        915         


