                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
	  Anthony Kihm
	  Russell Lingham
	  Anne Cieniewicz
	  Phil Cooper
	  Ken Boakye
	  Mark Chiu
	  Peter T. Buckley
     	  Steve Jarantow
	  Robert Perkinson
	  William Strohl
	  Yiqing Fend
	  Simon Hinke
	  Jean Whaley
	  Yin Liang
	  Dana Johnson
	  Keith Demarest
 
<120>  INSULIN RECEPTOR ANTIBODIES AND USES THEREOF

<130>  JBI5133WOPCT

<140>	  Unknown
<141>	  Herewith 

<150>	  62/536,158
<151>	  07-24-2017

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  940
<212>  PRT
<213>  Human

<400>  1

His Leu Tyr Pro Gly Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn 
1               5                   10                  15      


Leu Thr Arg Leu His Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His 
            20                  25                  30          


Leu Gln Ile Leu Leu Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp 
        35                  40                  45              


Leu Ser Phe Pro Lys Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe 
    50                  55                  60                  


Arg Val Tyr Gly Leu Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr 
65                  70                  75                  80  


Val Ile Arg Gly Ser Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe 
                85                  90                  95      


Glu Met Val His Leu Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile 
            100                 105                 110         


Thr Arg Gly Ser Val Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu 
        115                 120                 125             


Ala Thr Ile Asp Trp Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr 
    130                 135                 140                 


Ile Val Leu Asn Lys Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro 
145                 150                 155                 160 


Gly Thr Ala Lys Gly Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly 
                165                 170                 175     


Gln Phe Val Glu Arg Cys Trp Thr His Ser His Cys Gln Lys Val Cys 
            180                 185                 190         


Pro Thr Ile Cys Lys Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys 
        195                 200                 205             


His Ser Glu Cys Leu Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys 
    210                 215                 220                 


Cys Val Ala Cys Arg Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr 
225                 230                 235                 240 


Cys Pro Pro Pro Tyr Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe 
                245                 250                 255     


Ser Phe Cys Gln Asp Leu His His Lys Cys Lys Asn Ser Arg Arg Gln 
            260                 265                 270         


Gly Cys His Gln Tyr Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys 
        275                 280                 285             


Pro Ser Gly Tyr Thr Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys 
    290                 295                 300                 


Leu Gly Pro Cys Pro Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr 
305                 310                 315                 320 


Ile Asp Ser Val Thr Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile 
                325                 330                 335     


Asn Gly Ser Leu Ile Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala 
            340                 345                 350         


Glu Leu Glu Ala Asn Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu 
        355                 360                 365             


Lys Ile Arg Arg Ser Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys 
    370                 375                 380                 


Leu Arg Leu Ile Arg Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe 
385                 390                 395                 400 


Tyr Ala Leu Asp Asn Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys 
                405                 410                 415     


His Asn Leu Thr Ile Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro 
            420                 425                 430         


Lys Leu Cys Leu Ser Glu Ile His Lys Met Glu Glu Val Ser Gly Thr 
        435                 440                 445             


Lys Gly Arg Gln Glu Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp 
    450                 455                 460                 


Gln Ala Ser Cys Glu Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr 
465                 470                 475                 480 


Ser Phe Asp Lys Ile Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp 
                485                 490                 495     


Phe Arg Asp Leu Leu Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr 
            500                 505                 510         


Gln Asn Val Thr Glu Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser 
        515                 520                 525             


Trp Thr Val Val Asp Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys 
    530                 535                 540                 


Ser Gln Asn His Pro Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr 
545                 550                 555                 560 


Gln Tyr Ala Ile Phe Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg 
                565                 570                 575     


Arg Thr Tyr Gly Ala Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala 
            580                 585                 590         


Thr Asn Pro Ser Val Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser 
        595                 600                 605             


Ser Gln Ile Ile Leu Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn 
    610                 615                 620                 


Ile Thr His Tyr Leu Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu 
625                 630                 635                 640 


Leu Phe Glu Leu Asp Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg 
                645                 650                 655     


Thr Trp Ser Pro Pro Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln 
            660                 665                 670         


Ser Glu Tyr Glu Asp Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr 
        675                 680                 685             


Asp Ser Gln Ile Leu Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr 
    690                 695                 700                 


Phe Glu Asp Tyr Leu His Asn Val Val Phe Val Pro Arg Lys Thr Ser 
705                 710                 715                 720 


Ser Gly Thr Gly Ala Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser 
                725                 730                 735     


Leu Gly Asp Val Gly Asn Val Thr Val Ala Val Pro Thr Val Ala Ala 
            740                 745                 750         


Phe Pro Asn Thr Ser Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His 
        755                 760                 765             


Arg Pro Phe Glu Lys Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly 
    770                 775                 780                 


Leu Arg His Phe Thr Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln 
785                 790                 795                 800 


Asp Thr Pro Glu Glu Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg 
                805                 810                 815     


Thr Met Pro Glu Ala Lys Ala Asp Asp Ile Val Gly Pro Val Thr His 
            820                 825                 830         


Glu Ile Phe Glu Asn Asn Val Val His Leu Met Trp Gln Glu Pro Lys 
        835                 840                 845             


Glu Pro Asn Gly Leu Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr 
    850                 855                 860                 


Gly Asp Glu Glu Leu His Leu Cys Val Ser Arg Lys His Phe Ala Leu 
865                 870                 875                 880 


Glu Arg Gly Cys Arg Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val 
                885                 890                 895     


Arg Ile Arg Ala Thr Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro 
            900                 905                 910         


Thr Tyr Phe Tyr Val Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala 
        915                 920                 925             


Lys Ala His His His His His His His His His His 
    930                 935                 940 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Heavy chain CDR1

<400>  2

Ser Tyr Trp Ile Gly 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Heavy chain CDR2

<400>  3

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Heavy chain CDR3

<400>  4

Trp Ala Leu Leu Asn Leu Asp Tyr 
1               5               


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Light chain CDR1

<400>  5

Arg Ala Ser Gln Ser Val Gly Lys Ser Gly Leu Ala 
1               5                   10          


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Light chain CDR2

<400>  6

Asn Ala Ser Ser Arg Ala Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - Light chain CDR3

<400>  7

Gln Gln Tyr Asn Gly Pro Pro Leu Thr 
1               5                   


<210>  8
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - VH

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ala Leu Leu Asn Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB138 - VL

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Lys Ser 
            20                  25                  30          


Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asn Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Gly Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Heavy chain CDR1

<400>  10

Ser Tyr Trp Ile Gly 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Heavy chain CDR2

<400>  11

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Heavy chain CDR3

<400>  12

Asp Ile Gly Thr Gly Glu Phe Asp Tyr 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Light chain CDR1

<400>  13

Arg Ala Ser Gln Ser Val Asp Lys Ala Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Light chain CDR2

<400>  14

Tyr Ala Ser Asn Arg Ala Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Light chain CDR3

<400>  15

Gln Gln Arg Tyr Asp Trp Pro Tyr Thr 
1               5                   


<210>  16
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - VH

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Thr Gly Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  17
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  BBBB141 - Light chain VL

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Lys Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asp Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


