                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev Ltd.
 
<120>  SMAC/DIABLO INHIBITORS USEFUL FOR TREATING CANCER

<130>  NIBN/006 PCT

<150>  US62/537475
<151>  2017-07-27

<150>  US62/618646
<151>  2018-01-18

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  19873
<212>  DNA
<213>  Human

<400>  1
gagctcgggg accacgcgga ggttgtaatt ggtctctaga ccacacctag ttgttgagtg       60

ccgctgcttg aaaatctcag ttctgccgag atcgcagaat acacacaagc tacctttggg      120

caccagagca gacagaaccg cggagcttca gggtggaaga ttcgtggaaa ctttgccaag      180

taagtgaggt ggggagagaa ggaagccagt gcctgacact gtggggagtg gctgggcaaa      240

gcagcattgg aggtgttgta gggttcctac tgtctgatga gctggtgtgg ggttcttact      300

gtctgatgtc gtctctggtg gaagttagca gggctggggc agatgcacag agcacggtgg      360

cgggggtgag cccaggatcg gattgatgcc cacccaccac ctggcaccct gcagtcccag      420

ctggccagaa ggcaagcatg ctggaccaca aagcaaagat cctccagctc tgctgctggc      480

aagccttggg gccaggggac tcacagaaga gcaggtttgg gcctgtgcct tcctcctgcc      540

caaatgggtc tctctcccct tccccttcca gccagggccg cagctggggc tgcagcttga      600

gtgacgggaa aagaaaggtt tactccacca gcgcattagc ggcactcaca gcattaaaaa      660

tgcaggaggt ggtgggagga gcgggccagg gaggaaaact catgcagctg cggggcgcgg      720

ggaagagccg ggcttctgcc tcctcagccc ggatcagagc cgaagaacga gggcagtttg      780

ggttgagaag gattctccag tgtaaccgag aagcgagcgt ccaggaggct gttggggagg      840

tcggcactgt gggcttcctg gccttcgttt gctgtttcga gggccaggac ctcgtgtgtt      900

cccgtccgcc cctctgggac ggcgccagcc cggcaggccg ccgaccgtcc tggggctccc      960

gcgcagcgcg atgccggcct cgtccaccgt ccacgtgctg cagctgctgc gggagctgct     1020

cgccttcgtg ctcctcagct acacggtgct catcggggcg ctgctgctgg ccggctggac     1080

cacttacttc ctggtgctga agtgacagcg ccgtcgccgc gcccggcccc gcctcccgcc     1140

cggccccgcc tcccgcccgg ccccgcctcc ctaactcacc aggaaattcc cttcaagccc     1200

tggcccgaac tgagtccccg cccacccgcc agcgtcacgg cgcccgactc agctccgcgc     1260

cggacccacc tccgcgccct caggccctgc atatgccccg ccccgcgcgg aagttccggc     1320

ggttggttgc cttgcgcggc cgttacagcc tttgccctaa gcctcgcccc ctttccccct     1380

gcctgcccaa tcccgactgc ttccttgggt gggggcgtgg ctatggggcg aggcgctctc     1440

aggtggaggc cgtgccccgc tccgcgctca cgaagctgcg tcacttccgg cgtgtgcgtc     1500

tggcgtccgc gcgctgcaca atggcggctc tgaagagttg gctgtcgcgc agcgtaactt     1560

cattcttcag gtaccgctgc ggccgcgtag aggggacagg accagaggga gggaccgacg     1620

cggacagcgc tgtggcccgg cccacggcgc ccgccttcct tacgcgctca tctctcgtcc     1680

gcccagctgg gtcgcggcgt ctcgctccgg tcgggaggac tgaggacagc cccgcctccg     1740

ccccctgggt caagcccggc ttccttttca gttcgtccat cttctagaaa cgagtccccg     1800

agaccccggg ctgccttctt ggggctgctc cgcctcctga ccagccctcg tcagccactc     1860

gaagtccctg aggagacgtg gagaggagga gggacacggc atggggggag tccgggaagg     1920

gagacgagcg tctgaagacg tcctcccgag ggcagaaggg gccgggggag ctggcgcagg     1980

gctctctacc tagcgctgca ggctcctggg cgattgtagc gggaccgtca cacacaactg     2040

gcacccaggc caggggtcca gagctaaatt ctgcctgcag gagcggttat tgtggcatcc     2100

gtttctaaaa agtttaaagg caacatttta ttttatttta atttttttga gacaagatct     2160

gcctctgtcg cccaggctgg agtgcagtgg cgagatctca gctcactgca acctgtgcct     2220

cccggcttca agcgattctc agcctcagcc tcccgagtag ctgggattgc aggcgcccgc     2280

caccacgccc ggctaatttt tttttttctt tttgttttgt ttgagactca gtctcgctct     2340

gttgcccagg ctgaagtgca gtggggcgct ctcggctcac tgcaacctct gcctcccagg     2400

ttcaagcgat tctcctgcct cagcctcccg agtagctggg attacaggag cgtgccacca     2460

ctccgggcta atttttgtgt tttaagtaga gatggggttt caccatgttg gtcaggcaga     2520

tttcgaattc ctgacctcaa gtgatccacc cgcctcggcc tttatttact tatttttttt     2580

taatagacac ggggtcatgt tgccagccat gttgcccagg ctggtcgtga actcctgggc     2640

tcaagtgatc ctcccgcctt gcccttggcc ttccaagtgc taggattaca ggcgtgagcc     2700

accaacaccc tgcctgaggc aacattttaa acttggtgta tgttgaaaat ttcaaaaccc     2760

ctcagctgtc ctgcatcctc atttaggttc ctgcttggct cgagtttgag tttacagccc     2820

ctgcaagtaa atccaagagc ctgttacaga ttggcggtcg tgccttatga aatctgactt     2880

ctacttccag gtacagacag tgtttgtgtg ttcctgttgt ggctaacttt aagaagcggt     2940

gtttctcaga attgataaga ccatggcaca aaactgtgac gattggcttt ggagtaaccc     3000

tgtgtgcggt tcctattgca caggtactgt cgtgtgcagt gattcttatc tagtgtaccg     3060

tgtcctcttg aagtctcaag tgggcggtga agcattagac aagctaccat agtttttccc     3120

agtgctccca tcccttcccc cacagtaccg gcatcttttc acagttgagc agatatatta     3180

atattctcat tttgattatc tcatttggta ggaacagcac atcaaattgt ataaagcgag     3240

tagagagaaa taagaggata ttacagtcta tcaacaaagt agtctttgat tcaacagaaa     3300

tttattgagc aacttttatg tgcaagacac tgagaatgta agaatgaaca acaaaaaatt     3360

cttgttctca caaaagcttt gtggagatga aagaggataa aatataaaat atcagctggt     3420

gataaatggt gggaagaaaa cagggccggg cacagtggct gatgcccagg gctttgggag     3480

gctgaggtgg gaggatggct tgagctcagg agtttgagac cagcctagtc aacataggga     3540

gactctgtct ctacaaaaca gaaaaattta gccgggtgtg gtggctcaca cttctagtgg     3600

caactactca ggaggctgag gcaggaagat cacttgagcc caggagtttg aggctgcagt     3660

gagctatgat ctcaccactg ctctccagcc tgggtgacag ggcaagacct tttctcaaaa     3720

acaaaacaaa acaaatgagg taagtgaata ggcaattctg ggagggagtt ttgttttaga     3780

taaaggtggt caagctactc tgataaggcg aagtagagat ctgaatgttc tgaaagagcc     3840

attatactat ctggtgcggg gaggagcttg ccaggcagaa ggaactcaga aggacaaaga     3900

cctagaagca gaagtatgcc tggtatgtct gaggagcatg gagctaatgt gtctggaggc     3960

gaatggggga gaccgtaata gatgaagcca gagagttaac tgataatcag attgtgtcct     4020

ttgtattttg tgggccattg ttgtaaggct ttgggttttc tgaaaaagaa gccgcagaag     4080

atattttttt tttttttttt taaagacaga gtctcactct gttgccaggc tgcagtgcaa     4140

tggcacaatc ttggctcact gcaacctccg cctcccaggt tcaagcaatt ctcatgcctt     4200

agcctccggg tagctgggat tacaggggtg tgccaccgca cccagctagt ttttgtattt     4260

ttagtagaga tggggtttct ccatgcttgt gaggctggtc acgaacccct gacctcaggc     4320

gatccacacg cctcggcatc ccaaggtgct gggattacag gcctgagcca ccgtgcccgg     4380

ctgtcacaga ggatttttaa cacagaacta ttatgatctg acataaattt taaaagttaa     4440

aaggttgctg tgtggaacta ggaagactag ttgctatatc taggcatgaa atgatactgg     4500

cttggaccag gcaagcagaa gaggtgggga gaatttagct caacgtagtt agcaggagtt     4560

gctgatggat tggttgtcgg gtgtattctc tagattaggg gtccccaacc cctgggctgg     4620

tactggtctg tggcctgtta ggaagcaagc tgcacagcag gaggtgagtg gtgggcaggt     4680

gagcattact gcctgagctc tgcctctggg cagatcagca gtggcatggg attctcatag     4740

gagcacgaaa cctattgtga actacacgtg cgagggatct aggttgtgtg cttcttgtaa     4800

gaatctaatg cctcatgatc tgaggtggaa cagtttcatc ctgaaaccat cctcacccca     4860

cccagtccat gaaaaaattg tcttcaacag agccggtccc tggtgccaca aacgttgggg     4920

accactgctc tagattccaa aaattttttt tttttttttt ttttggagac ggagtctcgc     4980

tctgttgccc aggaagctct gcctcctggg ttcacaccat tctcctgcct cagcctcccg     5040

agtagctggg actacaggcg cccgccacca caccctgcta atttttttgt atttgtagta     5100

gggacagggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccacc     5160

tgcctcggcc tcccaaagtg ctgggattac aggcgtcagc cactgcacct ggccagattc     5220

caagattttt taaaggcctt agcaactgaa tgaatggcga tgccatttag taggatggag     5280

aggagtgggt tttgaaagga aaaaaatttt ttggaaatgt catttctaag atgtctagga     5340

aacatctagg tggagctgtc aattaagtag ttgatataaa agtggcactt catttaaaaa     5400

aatcatagct tatatgcttt atggggaaga gctagagagg aaaccagcaa gctccatttc     5460

agcaaaatat tcctgccact taacgtgtgt gttcatcaca aaaggaagat taattccatg     5520

tattacaagt attttcagca tcttctgagg ctcattcatg agccctcacc ttactgtgcc     5580

tcacttcagt tgtcatctct gcatgctgat gaatccatag ccctaaaacc cctcacttga     5640

ataccaggct attttcgacc acaattggga caacctttgt ttttttcatt caaaagattt     5700

ttttttaggt ttgtcctttc tcagttatta tattactttc taagcccagt taacctcagt     5760

tctgggccac atgactgggg tctctagtca tttagtacag caatgccact tccattcttc     5820

aaaacccctc agtggtcagc taggcacgat ggctctctct tgtaatccca gtacttttgg     5880

aggctgaggt gggaggatca ctgtaggcca agagttcgag accagcctga gaaacatagc     5940

gagaccaccc ctctacaaaa aataattagc taggtgtggt ggcgtgtgtc ggtagtccta     6000

gctacctggg aggcaggagg atgatttgat ttcaggagtt caaggctgca gtgagctggg     6060

atcacaacac tatactccat cctgggcaac agaatgagaa atgaaaaacc tacagtggct     6120

ttccatgagg cgttcagaac taaaattaaa ctaagtctcc ctgcactcca gggccctagt     6180

gagtctcatt tctcttagct ccaaccaggc tagatccctg gacatcccct gcaacaaaag     6240

tattattttc ctcattgtta cctattctcc aggatgcgtg gccattctga ttctaggtat     6300

ctttagtacc aagtctcacc tctatttaaa gcctttcctt attcctgtcc aacaactatc     6360

tcctcctttt tggccactta atattgtata ttttgatatt tgatgataat cctttggcac     6420

cctcctgagt catcagagca taatgggaag ggtacagact ttgaagtgag atttggtttg     6480

aggtctagat gtgacttttt ggaaaagtta cataactatt ctgagcttcc atgtcattgc     6540

ttgtaaataa gaaaggataa taactggact gttgtgagga acaagtgaaa acacattata     6600

aaatgtagca cattatgaag acttatcaga atattgagac aaaattagct tcttgtgagc     6660

agaggtgtct ttcttccttt tgtagtcctg tataagatgc ctaatgaata cttaattatt     6720

tgaaatataa agttcttgat ttgttcatat caaaaatatt tcttgactgc ctctttcaac     6780

atgcagtgat tctgagtgtt tgtactctga atagcaaaaa caagacaaca tagagtgatt     6840

gattttttgt ttttgttttt gttttgtttt gttttgtttt gagacgagtt tcactcttac     6900

cacccaggct ggagtgcaat ggcaagatct cggctcactg caacctccac ctcctgggtt     6960

caggcaattc tcctgcctca gcctcccgag tagctgggat tacaggtacc cgccaccacg     7020

cccagctaat ttgtgtcttt ttagtagaga cggggtttca ccatgttggc caggcttgtc     7080

tcaaactcct gatctcaggt gatctgcccg cctcagcctc ccaaagtgct gggattacag     7140

gtgtaagagt gctttgctga ggaggaaaaa ggcagagagt cagggaggat gtgtcattac     7200

agttgccagt atttagtcca ggtggccaca gtcccttaac tcttaaggta attatattag     7260

tctttccttt tttaaaatag ctgaggtcag ggtgggcatg gtggctcaca cctgtaatcc     7320

cagcactttg ggaggccaaa gcatgtgtat cacttgaggt caggagttca aaaccagcct     7380

gggcaacatg atgaaacccc atctctacta aatataccaa aaaaatagca aagcgtggtg     7440

gcaggtgcct gaaatcccag ccactgggga agctgaggca ggagaatcgc ttgaacccag     7500

gaggcggagg ttgcaatgag ccaagattga accactgcac tccagcctgg gtgatagagt     7560

gagactctgt ctcaaaaaaa aaaaataaaa taaccgaggt ccccccatca acactgtact     7620

gcttcattct gctcagaatt gccctccccc atccactttt tttttttttg gcgaaagagt     7680

cttgctctgt cgcccaggct ggagtgaagt ggcacgatct tggctctcac tgcaacctcc     7740

acctcctggg ttcaagcgat tctcctgcct cagcctctca agtagctggg actacaggtg     7800

cccaccacca tgcccagcta attttttttt ttttgtattt ttagtagagt tggggtttcg     7860

ccatgttggc caggctggtc tcgatctctt gaccttgtga tccacccgcc tcggcctccc     7920

aaactattgg gattacaggc gttagccacc atgcctggcc cactttatta gactcagctt     7980

aatcctcatc aaacttgtga agccttttct aagctattag cactcaacat agaactgatt     8040

gctcccttct gcatgccccc agtgtagctc atacatactc ctcccacagc ttccatgata     8100

catgattgtg ttcatttttc tagttctgtt agcccatcat cctgctctct ctacccctac     8160

acctgtgttt gagggcagag aatgtcttgt tgagacttgc gtctcaagta tctaacactg     8220

ttaatgaatg aattgtaatc ttatcaattt gttggttata atcaatagtt ttgggggttt     8280

ttttggtttt ttgttttttt tttgagatgt agtctcgctc tgtcaccagg ctggagcgca     8340

gtggtgcaat ctcggctcac tgcaacctct gcctcctggg ttcaagtgat tcttctgcct     8400

cagcctccca agtagctggg actacaggcg tgtgccacca cgcccagcta atttttgtat     8460

ttttagtaga gacggggttt caccatgttg gccaggatcg tctcaatctc ctgacctcgt     8520

gatctgcctg cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccgtgcccgg     8580

cacttttttt tttttttttt tagtcttgct ctgtcaccca ggctggagtg cagtggcagt     8640

ctcggctcac tgtaacctct gcctcctggg ttcagtcgat tctcctgcct cagcctcccg     8700

agtagctggg attaaagacg cacaccacta cggcccagct aatttttgta tttttttagt     8760

agagacgggg tttcaccatg ttggccagga tcgtctcaat ctcctgacct cgtgatctgc     8820

ctgcctcagc ctcccaaagt gctggtatta caggtgtgag ccaccgtacc ccgccacaat     8880

ttattttata tgtaaagaaa taatttgctt tttggagcag agaatgaaag ttggtagaaa     8940

gcatactccg gaattatttc tctatattgt cttaaattgc caaaataagg ccttaaaaaa     9000

tataacccaa agaaatatag tgcagtttca gcctaaaaca ctaagcagca tgacaattac     9060

gttttttgct tgcctattgg tgaaaaagtt ctcagtttga gctttagagg ttgagtgaca     9120

atgtttgtgt ctttcagaaa tcagagcctc attcccttag tagtgaagca ttgatgagga     9180

gagcagtgtc tttggtaaca gatagcacct ctacctttct ctctcagacc acatatgcgt     9240

tgattgaagc tattactgaa tatactaagg tatgtctcct cttaactctt gatcttctaa     9300

accatggttt agcaaataat ggctcacaac caaattgtgt ctgataccca tgttggtatt     9360

tgattgaaac atagccaggc ctatttgttt atgtgttgtc aataacggtt tttgaggatt     9420

tgagtagttt caacagaggc tgtaaggccc acaaagccca aaatatttac tgtcaggccc     9480

ttcaaaaagt ttgctgagcc ctgatctaaa tcactcgttt ttagactttt cccaggaacc     9540

tttttttttt tttttacaga aaaatcttaa atgtggcagc ctagtatata aaacaggagt     9600

gaagctgata tggttcagtt aagggcacag gggcctgtgg tccatcaaca gaggttgctc     9660

tgtgaggatt atttaaaagc cactgatcta acctaataga aaagagagta tatgggccag     9720

gcgtggtggc tcacatctgt aatcccagca gtttgggagg ccaaggcggg aggatcactt     9780

ggggccagga gttcaagacc aacccagtca atgtagcaag ccccatctct agcagaaaaa     9840

aaattttaaa cttagccagg catggtgtgt tgtgtgcctg tagtcccagt tactccaggg     9900

gctgaggtgg gaggatcact tgagtctagg agtttgagat tacagtgagc tatgaacatg     9960

ccagtgcact tccgtctggg tgacatagca tcctgtttgt aaaaaataat aaattttttt    10020

ttttgagatg gagtcttgct tacgcaggct ggagtgcagt ggagtgatgt cagctcgctg    10080

caatctccgc ctcctgggtt caagcgattt tccttcctca gcctcctgag tagctgggat    10140

tacaggtgtg tgccaccatg cccggctaat ttttttgtat ttttagtaga gacggggttt    10200

tgccatgttg gccaagctgg tctcgaactc ctgacttcag gtgatccacg tgtcttagcc    10260

tcccaaagtg ctaggattac aggcatgagc cactgcaccc ggccaataaa aattttttag    10320

cgtatatgga taatcaaaag tattgaagtc tcatttgtgc atttgtttta catatatttt    10380

ccagcagctt ttttcccctc aacctttaaa gttttccctt gcattgtttt ctctttctgt    10440

gtctgaattg ctgacaagct tttaaaaaca cagaagttta cagatggaga tactaatgtc    10500

ctgatacctt tacttcatag gataatagtg caatttcatt gaggcagcag gatggaagag    10560

ccagtttgct gtaatgggac ttaatttcct tgaggtggaa atctctctat tccttctgat    10620

atgtctcact tactttactc agacttgttc attctctatt tgtaggctgt ttatacctta    10680

acttctcttt accgacaata tacaagttta cttgggaaaa tgaattcaga ggaggaagat    10740

gaagtgtggc aggtgatcat aggagccaga gctgaggtaa gcagaaagtt ctaggcattt    10800

ctgtgttagt gcacctacct catgtggtat ctaaattatt gaattaagtc taatcaatat    10860

aatcagtgtt ctctaaatct actactttaa gtccatttaa atgggctaga cctcttatgc    10920

tgtctgaagc actttgcttg atttatatag atgacttcaa aacaccaaga gtacttgaag    10980

ctggaaacca cttggatgac tgcagttggt ctttcagaga tggcagcaga agctgcatat    11040

caaactggta ggttcaagtt ttgtgttggg tttttttttt aattttttaa ctaggaaggt    11100

accatttgag ttttcatctg gttttctaaa atgagggctt tatagtaaat ggtctaagtg    11160

gctctcactt tgagaaattt tccccatttc ctacatatta acctacattt tatttgcaca    11220

atagaaacaa tgagcatacc cttgcagacc agaccagtag aagctaggtt atgtcttcaa    11280

aatgaaaaat gataaaacta ttaccattgg aaaattggat tgcttccaaa tagttttagc    11340

ttcttttggt aatacaattt attaacaatc atagaattac accgttggct gagacttgag    11400

atgagtaatc tatgtgaacc tttttgtaca gatggagaaa atgagacctg gaatcatagt    11460

cagtggcaaa accaggacaa attatttgtc tatgtcaggc tttgtggtag gcatttcgta    11520

ggcacttttt atatgtgaag aaactagagg gcagatgggc cagatcattc ggctaagatg    11580

acacggtatg gtgagtaagc agccaagctg agattcagct gagtaggtct tttttttttt    11640

tttttttttt tccttcataa aatagagatg gggttttaca atgttgcaca ggctaatctc    11700

gaaatcctag gctcaagcag tctacccacc ttggcctccc aaagtgctgg gattataggc    11760

atgagccacg gagccaagta ggtcgaattc caaagcctct gcttctccta ttctcccagc    11820

agccagtgct ttgtcctttg caccgtggtg ccccaaggtg cccatcatag aacatcctac    11880

ctgagtggtc ccaacctagg taggtaggct cacagaaaaa aaaatttttt ttaatggagt    11940

tttgttcctg tcacccaggc tggagtgcac tggcgccatc taggctcact gcaacctcca    12000

cctcctgggt tcaagtgatt ctcctgcctc agcctcccaa gtagctggga ttacaggcac    12060

ccgccaccac gcccagctag tttttgtatt tttaatagag aatagttttt gtatttttaa    12120

tagagaaggg gttttgccat gttggccagg ctggtcttga actcctgacc tcaggtgatc    12180

cacccgcctt ggcctcccaa agtgctggga ttacaggcat gagccactgt gtccggccaa    12240

attttttttt ttttgagaca gagtttcact cttggtgccc aggctgcagt ggtagcactt    12300

tctcagctca ctgcaacctc tgcctctcca gttcaagcaa ttttcctgcc tcagcctccc    12360

gattacaagc atgcaccacc acgcctggct aatttttgta tttttagtag aggcaggttt    12420

cgtcatgttg ttcctcactt cagcctctca aagtgctggg attacaggtg cgagccaccg    12480

cacccagccg gctcaccaaa gttatagctt agtactagtt cttattaaga aactggttgc    12540

agtggctcat gcctataatc ccagcacttt ggggggccaa ggagggcgga tcacttgagg    12600

tgggtcactt gaggtcaaga gtttgacact accctggcca ccgtggtgaa accctgtctc    12660

tactaaaaat acaaaaatta gccaggtgta gtggcacacg cctgtgcagg agaatggctt    12720

gaacccaggg ggtggaggct gcagtgagcc tagatggctc cactgcacct caagccttgg    12780

tgacagagca agactctgtc tcaagaaaaa aaaaagaaac tgggatgagt caggcacagg    12840

gactcaacgc gtgtctttgg gaagccaagg caggcagatt gctggagccc aggagttcaa    12900

gggcaacaca gtgaaacccc atctctacca aaaatacaaa aattagctgg gcgtattggc    12960

gctcgcctgt agtcccagct actcgggagg cagaggtggg aggattgctt gaacccagga    13020

gctcaaggct gcagtgagct atgatcatgc ctgtgcactc catcctaggc aaaagagcta    13080

gaccctgtct caaaaaagaa attgttatat taaaacatac tcttgttttc tgatgtcaag    13140

attagcaggc tagggttctc aatcatcaaa tcttaaaaat gatacaaagg gctgggtgtg    13200

gtggctcaca cctgcaatcc cagctacttg ggagggtaag ataggaggat cacttgagcc    13260

tgggaggcag aggttgcagt gaggtgagat cattgcactc cagcctgtgc aacagagtga    13320

gaccccatct caaagaaaag atataaaaca ttttttaagg taagtgttgt gtcatcatac    13380

tgaaaaacaa aaaataattc ttttagaagg ttttttttgt tgttgttagt ttttttgttt    13440

gtttgttttt ttgagacagt ctcattccat cccccaggct ggagtgcagt ggtgtgaact    13500

cagctcactg caacctccac ctccctgctt caagcaattc tcttgcctct gcctcctgag    13560

tagttgggct tggaagcgcc tgccaccatg cctggctaat ttttttattt ttagtagaga    13620

cggagtttca ccatgttggc cagaccggtc ttgaattcct gatctcaggt gatctgcctg    13680

cctcggcctc ccaaagtgct gggattacag acatgagcca ctgcgcttgg cccagaaaaa    13740

gtagtgatcc tgagaaaaag tagtgatcct gagggatcag agatttggaa caagaatgaa    13800

acaacggaag tgtggaagca gcattatagt tgtgccacac aaacatggca gaggatttct    13860

aggtgcagtg aacaggagga tatgcttata tctagaagga gaaaaggaga atatctagaa    13920

ggagaaaagg aggggatgta taagcattat ttgagaaaag tagacatttt cctagaactc    13980

atagaaaggg ctaacaaagt tgtaaacgga attttttttt tttttttccc tgagacaagg    14040

tcttactctg ttaccaggct ggagtacagt ggcacaatca tggctcactg cttactacag    14100

ccttagcctc tgggctcaag cgatcctacc atgtcagtct cccaggtagc tgggattata    14160

tgtttccggt agagacagga ttttgccatg ttgtccaggc tggtcttgaa ctcctgagct    14220

caagtgatcc acccgccttg gcctctcaaa ctgctgggat tacagacatg agacactgtg    14280

cacggcctta tgatttcact tttttaacca aaaatctggt ccaggtgcag tggctcatac    14340

ctgttgtaat cccagcactt cgggatgcct aagcaggtgg atcacttgag ctcaggagtt    14400

cgagaccaga cttgacaaca cgatgaaacc ctgtctctac aaaaaaatta gccaggcatg    14460

gtgatgggcg cctgtagtcc cagcttcttg ggaggctgag gtgagaggat cacttgggcc    14520

ctggaggtcg aggctgcagt gagccatgat caggccagtg taccccagcc tggttgacaa    14580

agcaagaccc tgtcttaaaa acaaaaaaat ggccgggcgc agtggctcac gcctgtaatc    14640

ccagcacttt aggaggctga ggtgggcgga tcatgtggtc aggagataaa gaccatcctg    14700

gttaacatgg taaaaccccg tctctactaa aaatacaaaa aaattagcta tgtgtggtgg    14760

cgggtgcctg tagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacctggg    14820

aggcagagct tgcagtgagc agagatcaca ccactgcact ccaccctggg caacagagca    14880

agactccatc tcaaaaaaaa aaacaaaaat aaataaataa gcgaacaata aagtaacagc    14940

ataacaaaaa gattcagagc aaaatcccaa aagctactaa gaaaaaatag attacctaca    15000

aaggaagtag aatcaaacat caggcatctt ctccgcaaca ctagaggtga cgataaatcc    15060

ataacctagg attttatgta tagccaacta ccatcaaaaa gtgagaataa aagatatcct    15120

cagacataga ctcaaagtac cacctgtata cactttctgg aagaactatg aagaaggaaa    15180

aatcagtttt gagagaagct actaagattt tttttcaaaa gttctgagtg taaaacaagt    15240

ttttaaattt gggaaagtga aaacatgcta agcacattga cattagacat tgttaaacac    15300

tgcaaagaga attagtagga gtgggaggaa acttggtagc tccagttgag gcaggaaagg    15360

tttaaaaaga aaacccgtca attagaaaat acaaaattgg gccacgtgca gtagttcaca    15420

cctatgatcc cagcactttg gaaggccaag tcagatggat cagctgaggt caagagttcg    15480

agaccagcct ggccaacatg gcaaaactcc atctgtaatt taaaaaaaaa aaaaaaaaat    15540

tataggaata atttcaaaca tcagtgattg cagtaaaaat aaacttatta aatgacacgt    15600

ttagattgtg ttccaaaatt tagctaaaac tagctaaatc aaagaattca agataaaaag    15660

taatcagtag gacagaacaa ttcattaaga cattatcaat catgaaatgt acttaatgag    15720

gcaaaaactg atagaattac aaggagatct gagatgtgtg taatactcaa ttttctgagc    15780

acgcttgcag gtcaagacaa ccaaaaaaat taaagctatt aaagctatta aggattagaa    15840

cagaatttgt tttggagaca gggtcttgct ctgttgccca ggctggagtg taatggcatg    15900

atcacagctt actgcagcct tgacctgggc tcaagccatc ttcccatttc agcgtcccaa    15960

gcagcccaac taattttctt tttttttttt aagagttggt gtcttgttat gttccccagg    16020

ctgattttga actcatgggc tcaagtgatc ctcccgtctt ggcctgccag agtgctagga    16080

tcacaggcgt gagctgagcc actgcaccca gctcagtgtg attgtttttt attttggaga    16140

cagggtctca ctctgtcacc cgggttggag tgcagttcct tgatcttggc tcaccgttac    16200

ttctgcctcc cagggtcaag caatcctgtc tcagcctcct gagtagctgg gaccacaggc    16260

agtcaccacc acgcccgatt aatctttttt attttttggt agagatgggg tttcaccatg    16320

ttgcccaggc tagtctcgaa ctcctgagct aaggcagtcc acctgcctca gcctcccaaa    16380

gtgctgggat tacaggcgtg agccactgtg cccgtctgtg attttttttt tttttttttt    16440

tttttttttt tttttttact tttaactaaa caaaggaaaa tcagatttgt gtgtgtgaga    16500

gagacagggt ccatgcggga atgctgtggt gggatcatag atcatagctt gctgtagtct    16560

caacctcctg gactcaagtg atcctcccca ctttagcctc cccagtagct gggattacag    16620

gtgcacacca ccatgcccca gctaattttt ttatttttag tagaaacaga gttttgctaa    16680

gtttcccagg ctggttttgc agagtggttt ttaaacacct aacaaatgta tatatactaa    16740

atataaaact ttgccccctc cctctaaatt tacatactct tctaagacac acagtaaatt    16800

ttgtaccagg tgacaaaagg aagagacaac aaaatcattt aaaaagttga tatatcacct    16860

gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccaaggcg ggtggatcac    16920

gaggtcagga gatcaagacc atcctggcta acgtggtgaa accccgtctc tactaaaata    16980

aaaaaaataa ataaataaat taggcatggt ggtgggcacc tgtagtccca gctactcagg    17040

aggctgaggc aggagaatgg cgtgaacccg ggaggtggag cttacagtga gccgagatcg    17100

cgccactgca ctccagcctg ggtgataagt gagactccat ctcaaaaaaa aaaaaaaaaa    17160

aaaggtagaa atggtattcg aagattttga tgtccccaaa atggacacca gggcctagga    17220

tgtttcgtgg gagagtttta tcaaatcttc caaaactata atacctatgt tactgtaagt    17280

gtaccagcgc aaagaaagta atgacaagcc tcctcttact actgtatgaa gccagcatag    17340

ccccgatccc aaactggact agggcagcac caaaacgaaa agctcagtat cacttcaaaa    17400

tgtagccgta aatcaaacgt agccatttac cctcaaaata gaatgatagt tcaacactgt    17460

aaaaaactat agagtgagac tccttctcaa acaaatataa ttcactgttt gagatgatat    17520

atccatagat taaaggagaa aaaccactta acatatgccc aaaacatctt cagtgtagta    17580

gccatttatg attcgaatct aagtacaatt atgaagagat aattttctta atgtaataaa    17640

ggttaagtaa tcctacttaa ttgtgtggac tttcagaagt gttttcatcg aagttagaag    17700

aggaggatgc ctgccattct ccactacctg tcaacattgt cctgaaggtt cttgttaatg    17760

cagtaagatc aaaatgttct acagacgaat tgataaaatg tatataccca gatggtgaaa    17820

tacactaact agcagcaggt aaaatgagag agctcatttt tttttttggg ggggagacga    17880

gtttcactct cacctaggct ggagtgaagt ggcgcgatct cagctcactg caacctccgc    17940

ctcccaggtt caagcaattc tcctgcttca ggctcccaag tagctgagac tgcaggtgca    18000

ctctgccaca cccagctact ttttttgtat tttagtagaa acggggtttc accgtgttac    18060

ccaggctggt cttgaactcc tgagctcagg cagtccaccc acctcggcat cccaaagtgc    18120

taggattaca ggcacgagcc actgcaccca gccttttttc tttttttctt ttttttttga    18180

gacggagtct gtcgcccagg ctggagtgca gtggcacgat cttggctcac ttcagccttc    18240

gcctcccggg tccaagctat tctcctgcct cagcctccca agtagctggg attacaggca    18300

tgcgccacca tgcctggcta attttttttt gtatttttgg tagagacggg ttcaccatgt    18360

tagccaggct ggtctcgaac ttctgaccct caggtgatct gcctgccttg gcttcccaaa    18420

gttctgagat tagaggcgtg agccactgcg cccggccttc aaaacatgtt taagtgaaaa    18480

aattataaaa catatttaat accttttatg ctgttacata aatttatagt aaaaaaatat    18540

ttttctatgc attcctttac ctttaaagat tagtcaaggt gatgaaaggg atctttgaca    18600

attttattca tgatctcttt gtcaaaaaga aatggaagat gtgtagttaa aaaaattaat    18660

caaaggtctg tactaaaagc tctgtagcta taaagatgat tgtgagagtt gcatttaata    18720

attgtgatgt tggccgctga cagctgaaga aaaatgctgt ttttgacaga gtgtcagtta    18780

aatccagacc tgaacataga ggtggaagtt tctttgcaga gagagaagac agggaggtca    18840

aggaaagtga ccccaagagg ggttcagatg acagccacag cacccccagg ccaacgtcca    18900

catgagcctt ccgcgccctg cacggctgct caacccgatt gtcccatctt ttggcaggcg    18960

cagatcaggc ctctataacc gccaggaatc acattcagct ggtgaaactg caggtggaag    19020

aggtgcacca gctctcccgg aaagcagaaa ccaagctggc agaagcacag atagaagagc    19080

tccgtcagaa aacacaggag gaaggggagg agcgggctga gtcggagcag gaggcctacc    19140

tgcgtgagga ttgagggcct gagcacactg ccctgtctcc ccactcagtg gggaaagcag    19200

gggcagatgc caccctgccc agggttggca tgactgtctg tgcaccgaga agaggcggca    19260

gatcctgccc tggccaatca ggcgagacgc ctttgtgagc tgtgagtgcc tcctgtggtc    19320

tcaggcttgc gctggacctg gttcttagcc cttgggcact gcaccctgtt taacatttca    19380

ccccactctg tacagctgct cttacccatt ttttttacct cacacccaaa gcattttgcc    19440

tacctgggtc agagagagga gtcctttttg tcatgccctt aagttcagca actgtttaac    19500

ctgttttcag tcttatttac gtcgtcaaaa atgatttagt acttgttccc tctgttggga    19560

tgccagttgt ggcaggggga ggggaacctg tccagtttgt acgatttctt tgtatgtatt    19620

tctgatgtgt tctctgatct gcccccactg tcctgtgagg acagctgagg ccaaggagtg    19680

aaaaacctat tactactaag agaaggggtg cagagtgttt acctggtgct ctcaacagga    19740

cttaacatca acaggactta acacaggcct cttgttcctt cctttctttc cgtttctcta    19800

ttgtatccaa aggagaagag tgtaagattt tgtttgcatc tgaaagagaa aatgcgtctc    19860

tcctggggtc cta                                                       19873


<210>  2
<211>  239
<212>  PRT
<213>  Human

<400>  2

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Lys Ser Glu 
    50                  55                  60                  


Pro His Ser Leu Ser Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu 
65                  70                  75                  80  


Val Thr Asp Ser Thr Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu 
                85                  90                  95      


Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser 
            100                 105                 110         


Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu 
        115                 120                 125             


Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr 
    130                 135                 140                 


Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala 
145                 150                 155                 160 


Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala 
                165                 170                 175     


Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu 
            180                 185                 190         


Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu 
        195                 200                 205             


Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly 
    210                 215                 220                 


Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
225                 230                 235                 


<210>  3
<211>  2278
<212>  DNA
<213>  Human

<400>  3
gagctcgggg accacgcgga ggttgtaatt ggtctctaga ccacacctag ttgttgagtg       60

ccgctgcttg aaaatctcag ttctgccgag atcgcagaat acacacaagc tacctttggg      120

caccagagca gacagaaccg cggagcttca gggtggaaga ttcgtggaaa ctttgccaag      180

gccaggacct cgtgtgttcc cgtccgcccc tctgggacgg cgccagcccg gcaggccgcc      240

gaccgtcctg gggctcccgc gcagcgcgat gccggcctcg tccaccgtcc acgtgctgca      300

gctgctgcgg gagctgctcg ccttcgtgct cctcagctac acggtgctca tcggggcgct      360

gctgctggcc ggctggacca cttacttcct ggtgctgaag tgacagcgcc gtcgccgcgc      420

ccggccccgc ctcccgcccg gccccgcctc ccgcccggcc ccgcctccct aactcaccag      480

gaaattccct tcaagccctg gcccgaactg agtccccgcc cacccgccag cgtcacggcg      540

cccgactcag ctccgcgccg gacccacctc cgcgccctca ggccctgcat atgccccgcc      600

ccgcgcggaa gttccggcgg ttggttgcct tgcgcggccg ttacagcctt tgccctaagc      660

ctcgccccct ttccccctgc ctgcccaatc ccgactgctt ccttgggtgg gggcgtggct      720

atggggcgag gcgctctcag gtggaggccg tgccccgctc cgcgctcacg aagctgcgtc      780

acttccggcg tgtgcgtctg gcgtccgcgc gctgcacaat ggcggctctg aagagttggc      840

tgtcgcgcag cgtaacttca ttcttcaggt acagacagtg tttgtgtgtt cctgttgtgg      900

ctaactttaa gaagcggtgt ttctcagaat tgataagacc atggcacaaa actgtgacga      960

ttggctttgg agtaaccctg tgtgcggttc ctattgcaca gaaatcagag cctcattccc     1020

ttagtagtga agcattgatg aggagagcag tgtctttggt aacagatagc acctctacct     1080

ttctctctca gaccacatat gcgttgattg aagctattac tgaatatact aaggctgttt     1140

ataccttaac ttctctttac cgacaatata caagtttact tgggaaaatg aattcagagg     1200

aggaagatga agtgtggcag gtgatcatag gagccagagc tgagatgact tcaaaacacc     1260

aagagtactt gaagctggaa accacttgga tgactgcagt tggtctttca gagatggcag     1320

cagaagctgc atatcaaact ggcgcagatc aggcctctat aaccgccagg aatcacattc     1380

agctggtgaa actgcaggtg gaagaggtgc accagctctc ccggaaagca gaaaccaagc     1440

tggcagaagc acagatagaa gagctccgtc agaaaacaca ggaggaaggg gaggagcggg     1500

ctgagtcgga gcaggaggcc tacctgcgtg aggattgagg gcctgagcac actgccctgt     1560

ctccccactc agtggggaaa gcaggggcag atgccaccct gcccagggtt ggcatgactg     1620

tctgtgcacc gagaagaggc ggcagatcct gccctggcca atcaggcgag acgcctttgt     1680

gagctgtgag tgcctcctgt ggtctcaggc ttgcgctgga cctggttctt agcccttggg     1740

cactgcaccc tgtttaacat ttcaccccac tctgtacagc tgctcttacc catttttttt     1800

acctcacacc caaagcattt tgcctacctg ggtcagagag aggagtcctt tttgtcatgc     1860

ccttaagttc agcaactgtt taacctgttt tcagtcttat ttacgtcgtc aaaaatgatt     1920

tagtacttgt tccctctgtt gggatgccag ttgtggcagg gggaggggaa cctgtccagt     1980

ttgtacgatt tctttgtatg tatttctgat gtgttctctg atctgccccc actgtcctgt     2040

gaggacagct gaggccaagg agtgaaaaac ctattactac taagagaagg ggtgcagagt     2100

gtttacctgg tgctctcaac aggacttaac atcaacagga cttaacacag gcctcttgtt     2160

ccttcctttc tttccgtttc tctattgtat ccaaaggaga agagtgtaag attttgtttg     2220

catctgaaag agaaaatgcg tctctcctgg ggtcctaaaa aaaaaaaaaa aaaaaaaa       2278


<210>  4
<211>  195
<212>  PRT
<213>  Human

<400>  4

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Ala Val Tyr 
    50                  55                  60                  


Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met 
65                  70                  75                  80  


Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg 
                85                  90                  95      


Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr 
            100                 105                 110         


Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr 
        115                 120                 125             


Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln 
    130                 135                 140                 


Leu Val Lys Leu Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala 
145                 150                 155                 160 


Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr 
                165                 170                 175     


Gln Glu Glu Gly Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu 
            180                 185                 190         


Arg Glu Asp 
        195 


<210>  5
<211>  1882
<212>  DNA
<213>  Human

<400>  5
cgcgatgccg gcctcgtcca ccgtccacgt gctgcagctg ctgcgggagc tgctcgcctt       60

cgtgctcctc agctacacgg tgctcatcgg ggcgctgctg ctggccggct ggaccactta      120

cttcctggtg ctgaagtgac agcgccgtcg ccgcgcccgg ccccgcctcc cgcccggccc      180

cgcctcccgc ccggccccgc ctccctaact caccaggaaa ttcccttcaa gccctggccc      240

gaactgagtc cccgcccacc cgccagcgtc acggcgcccg actcagctcc gcgccggacc      300

cacctccgcg ccctcaggcc ctgcatatgc cccgccccgc gcggaagttc cggcggttgg      360

ttgccttgcg cggccgttac agcctttgcc ctaagcctcg ccccctttcc ccctgcctgc      420

ccaatcccga ctgcttcctt gggtgggggc gtggctatgg ggcgaggcgc tctcaggtgg      480

aggccgtgcc ccgctccgcg ctcacgaagc tgcgtcactt ccggcgtgtg cgtctggcgt      540

ccgcgcgctg cacaatggcg gctctgaaga gttggctgtc gcgcagcgta acttcattct      600

tcaggtacag acagtgtttg tgtgttcctg ttgtggctaa ctttaagaag cggtgtttct      660

cagaattgat aagaccatgg cacaaaactg tgacgattgg ctttggagta accctgtgtg      720

cggttcctat tgcacaggct gtttatacct taacttctct ttaccgacaa tatacaagtt      780

tacttgggaa aatgaattca gaggaggaag atgaagtgtg gcaggtgatc ataggagcca      840

gagctgagat gacttcaaaa caccaagagt acttgaagct ggaaaccact tggatgactg      900

cagttggtct ttcagagatg gcagcagaag ctgcatatca aactggcgca gatcaggcct      960

ctataaccgc caggaatcac attcagctgg tgaaactgca ggtggaagag gtgcaccagc     1020

tctcccggaa agcagaaacc aagctggcag aagcacagat agaagagctc cgtcagaaaa     1080

cacaggagga aggggaggag cgggctgagt cggagcagga ggcctacctg cgtgaggatt     1140

gagggcctga gcacactgcc ctgtctcccc actcagtggg gaaagcaggg gcagatgcca     1200

ccctgcccag ggttggcatg actgtctgtg caccgagaag aggcggcaga tcctgccctg     1260

gccaatcagg cgagacgcct ttgtgagctg tgagtgcctc ctgtggtctc aggcttgcgc     1320

tggacctggt tcttagccct tgggcactgc accctgttta acatttcacc ccactctgta     1380

cagctgctct tacccatttt ttttacctca cacccaaagc attttgccta cctgggtcag     1440

agagaggagt cctttttgtc atgcccttaa gttcagcaac tgtttaacct gttttcagtc     1500

ttatttacgt cgtcaaaaat gatttagtac ttgttccctc tgttgggatg ccagttgtgg     1560

cagggggagg ggaacctgtc cagtttgtac gatttctttg tatgtatttc tgatgtgttc     1620

tctgatctgc ccccactgtc ctgtgaggac agctgaggcc aaggagtgaa aaacctatta     1680

ctactaagag aaggggtgca gagtgtttac ctggtgctct caacaggact taacatcaac     1740

aggacttaac acaggcctct tgttccttcc tttctttccg tttctctatt gtatccaaag     1800

gagaagagtg taagattttg tttgcatctg aaagagaaaa tgcgtctctc ctggggtcct     1860

aaaaaaaaaa aaaaaaaaaa aa                                              1882


<210>  6
<211>  186
<212>  PRT
<213>  Human

<400>  6

Met Lys Ser Asp Phe Tyr Phe Gln Lys Ser Glu Pro His Ser Leu Ser 
1               5                   10                  15      


Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr 
            20                  25                  30          


Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr 
        35                  40                  45              


Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr 
    50                  55                  60                  


Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp 
65                  70                  75                  80  


Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu 
                85                  90                  95      


Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu 
            100                 105                 110         


Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile 
        115                 120                 125             


Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val 
    130                 135                 140                 


His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu 
                165                 170                 175     


Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
            180                 185     


<210>  7
<211>  2483
<212>  DNA
<213>  Human

<400>  7
agctgggtcg cggcgtctcg ctccggtcgg gaggactgag gacagccccg cctccgcccc       60

ctgggtcaag cccggcttcc ttttcagttc gtccatcttc tagaaacgag tccccgagac      120

cccgggctgc cttcttgggg ctgctccgcc tcctgaccag ccctcgtcag ccactcgaag      180

tccctgagga gacgtggaga ggaggaggga cacggcatgg ggggagtccg ggaagggaga      240

cgagcgtctg aagacgtcct cccgagggca gaaggggccg ggggagctgg cgcagggctc      300

tctacctagc gctgcaggct cctgggcgat tgtagcggga ccgtcacaca caactggcac      360

ccaggccagg ggtccagagc taaattctgc ctgcaggagc ggttattgtg gcatccgttt      420

ctaaaaagtt taaaggcaac attttatttt attttaattt ttttgagaca agatctgcct      480

ctgtcgccca ggctggagtg cagtggcgag atctcagctc actgcaacct gtgcctcccg      540

gcttcaagcg attctcagcc tcagcctccc gagtagctgg gattgcaggc gcccgccacc      600

acgcccggct aatttttttt tttctttttg ttttgtttga gactcagtct cgctctgttg      660

cccaggctga agtgcagtgg ggcgctctcg gctcactgca acctctgcct cccaggttca      720

agcgattctc ctgcctcagc ctcccgagta gctgggatta caggagcgtg ccaccactcc      780

gggctaattt ttgtgtttta agtagagatg gggtttcacc atgttggtca ggcagatttc      840

gaattcctga cctcaagtga tccacccgcc tcggccttta tttacttatt tttttttaat      900

agacacgggg tcatgttgcc agccatgttg cccaggctgg tcgtgaactc ctgggctcaa      960

gtgatcctcc cgccttgccc ttggccttcc aagtgctagg attacaggcg tgagccacca     1020

acaccctgcc tgaggcaaca ttttaaactt ggtgtatgtt gaaaatttca aaacccctca     1080

gctgtcctgc atcctcattt aggttcctgc ttggctcgag tttgagttta cagcccctgc     1140

aagtaaatcc aagagcctgt tacagattgg cggtcgtgcc ttatgaaatc tgacttctac     1200

ttccagaaat cagagcctca ttcccttagt agtgaagcat tgatgaggag agcagtgtct     1260

ttggtaacag atagcacctc tacctttctc tctcagacca catatgcgtt gattgaagct     1320

attactgaat atactaaggc tgtttatacc ttaacttctc tttaccgaca atatacaagt     1380

ttacttggga aaatgaattc agaggaggaa gatgaagtgt ggcaggtgat cataggagcc     1440

agagctgaga tgacttcaaa acaccaagag tacttgaagc tggaaaccac ttggatgact     1500

gcagttggtc tttcagagat ggcagcagaa gctgcatatc aaactggcgc agatcaggcc     1560

tctataaccg ccaggaatca cattcagctg gtgaaactgc aggtggaaga ggtgcaccag     1620

ctctcccgga aagcagaaac caagctggca gaagcacaga tagaagagct ccgtcagaaa     1680

acacaggagg aaggggagga gcgggctgag tcggagcagg aggcctacct gcgtgaggat     1740

tgagggcctg agcacactgc cctgtctccc cactcagtgg ggaaagcagg ggcagatgcc     1800

accctgccca gggttggcat gactgtctgt gcaccgagaa gaggcggcag atcctgccct     1860

ggccaatcag gcgagacgcc tttgtgagct gtgagtgcct cctgtggtct caggcttgcg     1920

ctggacctgg ttcttagccc ttgggcactg caccctgttt aacatttcac cccactctgt     1980

acagctgctc ttacccattt tttttacctc acacccaaag cattttgcct acctgggtca     2040

gagagaggag tcctttttgt catgccctta agttcagcaa ctgtttaacc tgttttcagt     2100

cttatttacg tcgtcaaaaa tgatttagta cttgttccct ctgttgggat gccagttgtg     2160

gcagggggag gggaacctgt ccagtttgta cgatttcttt gtatgtattt ctgatgtgtt     2220

ctctgatctg cccccactgt cctgtgagga cagctgaggc caaggagtga aaaacctatt     2280

actactaaga gaaggggtgc agagtgttta cctggtgctc tcaacaggac ttaacatcaa     2340

caggacttaa cacaggcctc ttgttccttc ctttctttcc gtttctctat tgtatccaaa     2400

ggagaagagt gtaagatttt gtttgcatct gaaagagaaa atgcgtctct cctggggtcc     2460

taaaaaaaaa aaaaaaaaaa aaa                                             2483


<210>  8
<211>  142
<212>  PRT
<213>  Human

<400>  8

Met Lys Ser Asp Phe Tyr Phe Gln Ala Val Tyr Thr Leu Thr Ser Leu 
1               5                   10                  15      


Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu 
            20                  25                  30          


Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser 
        35                  40                  45              


Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val 
    50                  55                  60                  


Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp 
65                  70                  75                  80  


Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln 
                85                  90                  95      


Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala 
            100                 105                 110         


Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu 
        115                 120                 125             


Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
    130                 135                 140         


<210>  9
<211>  1853
<212>  DNA
<213>  Human

<400>  9
cgcgatgccg gcctcgtcca ccgtccacgt gctgcagctg ctgcgggagc tgctcgcctt       60

cgtgctcctc agctacacgg tgctcatcgg ggcgctgctg ctggccggct ggaccactta      120

cttcctggtg ctgaagtgac agcgccgtcg ccgcgcccgg ccccgcctcc cgcccggccc      180

cgcctcccgc ccggccccgc ctccctaact caccaggaaa ttcccttcaa gccctggccc      240

gaactgagtc cccgcccacc cgccagcgtc acggcgcccg actcagctcc gcgccggacc      300

cacctccgcg ccctcaggcc ctgcatatgc cccgccccgc gcggaagttc cggcggttgg      360

ttgccttgcg cggccgttac agcctttgcc ctaagcctcg ccccctttcc ccctgcctgc      420

ccaatcccga ctgcttcctt gggtgggggc gtggctatgg ggcgaggcgc tctcaggtgg      480

aggccgtgcc ccgctccgcg ctcacgaagc tgcgtcactt ccggcgtgtg cgtctggcgt      540

ccgcgcgctg cacaatggcg gctctgaaga gttggctgtc gcgcagcgta acttcattct      600

tcaggttcct gcttggctcg agtttgagtt tacagcccct gcaagtaaat ccaagagcct      660

gttacagatt ggcggtcgtg ccttatgaaa tctgacttct acttccaggc tgtttatacc      720

ttaacttctc tttaccgaca atatacaagt ttacttggga aaatgaattc agaggaggaa      780

gatgaagtgt ggcaggtgat cataggagcc agagctgaga tgacttcaaa acaccaagag      840

tacttgaagc tggaaaccac ttggatgact gcagttggtc tttcagagat ggcagcagaa      900

gctgcatatc aaactggcgc agatcaggcc tctataaccg ccaggaatca cattcagctg      960

gtgaaactgc aggtggaaga ggtgcaccag ctctcccgga aagcagaaac caagctggca     1020

gaagcacaga tagaagagct ccgtcagaaa acacaggagg aaggggagga gcgggctgag     1080

tcggagcagg aggcctacct gcgtgaggat tgagggcctg agcacactgc cctgtctccc     1140

cactcagtgg ggaaagcagg ggcagatgcc accctgccca gggttggcat gactgtctgt     1200

gcaccgagaa gaggcggcag atcctgccct ggccaatcag gcgagacgcc tttgtgagct     1260

gtgagtgcct cctgtggtct caggcttgcg ctggacctgg ttcttagccc ttgggcactg     1320

caccctgttt aacatttcac cccactctgt acagctgctc ttacccattt tttttacctc     1380

acacccaaag cattttgcct acctgggtca gagagaggag tcctttttgt catgccctta     1440

agttcagcaa ctgtttaacc tgttttcagt cttatttacg tcgtcaaaaa tgatttagta     1500

cttgttccct ctgttgggat gccagttgtg gcagggggag gggaacctgt ccagtttgta     1560

cgatttcttt gtatgtattt ctgatgtgtt ctctgatctg cccccactgt cctgtgagga     1620

cagctgaggc caaggagtga aaaacctatt actactaaga gaaggggtgc agagtgttta     1680

cctggtgctc tcaacaggac ttaacatcaa caggacttaa cacaggcctc ttgttccttc     1740

ctttctttcc gtttctctat tgtatccaaa ggagaagagt gtaagatttt gtttgcatct     1800

gaaagagaaa atgcgtctct cctggggtcc taaaaaaaaa aaaaaaaaaa aaa            1853


<210>  10
<211>  166
<212>  PRT
<213>  Human

<400>  10

Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr Ser Thr Phe Leu 
1               5                   10                  15      


Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr Glu Tyr Thr Lys 
            20                  25                  30          


Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser Leu Leu 
        35                  40                  45              


Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val Ile Ile 
    50                  55                  60                  


Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu Lys Leu 
65                  70                  75                  80  


Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala Ala Glu 
                85                  90                  95      


Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala Arg Asn 
            100                 105                 110         


His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val His Gln Leu Ser 
        115                 120                 125             


Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu Leu Arg 
    130                 135                 140                 


Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu Ser Glu Gln Glu 
145                 150                 155                 160 


Ala Tyr Leu Arg Glu Asp 
                165     


<210>  11
<211>  1881
<212>  DNA
<213>  Human

<400>  11
cgcgatgccg gcctcgtcca ccgtccacgt gctgcagctg ctgcgggagc tgctcgcctt       60

cgtgctcctc agctacacgg tgctcatcgg ggcgctgctg ctggccggct ggaccactta      120

cttcctggtg ctgaagtgac agcgccgtcg ccgcgcccgg ccccgcctcc cgcccggccc      180

cgcctcccgc ccggccccgc ctccctaact caccaggaaa ttcccttcaa gccctggccc      240

gaactgagtc cccgcccacc cgccagcgtc acggcgcccg actcagctcc gcgccggacc      300

cacctccgcg ccctcaggcc ctgcatatgc cccgccccgc gcggaagttc cggcggttgg      360

ttgccttgcg cggccgttac agcctttgcc ctaagcctcg ccccctttcc ccctgcctgc      420

ccaatcccga ctgcttcctt gggtgggggc gtggctatgg ggcgaggcgc tctcaggtgg      480

aggccgtgcc ccgctccgcg ctcacgaagc tgcgtcactt ccggcgtgtg cgtctggcgt      540

ccgcgcgctg cacaatggcg gctctgaaga gttggctgtc gcgcagcgta acttcattct      600

tcagaaatca gagcctcatt cccttagtag tgaagcattg atgaggagag cagtgtcttt      660

ggtaacagat agcacctcta cctttctctc tcagaccaca tatgcgttga ttgaagctat      720

tactgaatat actaaggctg tttatacctt aacttctctt taccgacaat atacaagttt      780

acttgggaaa atgaattcag aggaggaaga tgaagtgtgg caggtgatca taggagccag      840

agctgagatg acttcaaaac accaagagta cttgaagctg gaaaccactt ggatgactgc      900

agttggtctt tcagagatgg cagcagaagc tgcatatcaa actggcgcag atcaggcctc      960

tataaccgcc aggaatcaca ttcagctggt gaaactgcag gtggaagagg tgcaccagct     1020

ctcccggaaa gcagaaacca agctggcaga agcacagata gaagagctcc gtcagaaaac     1080

acaggaggaa ggggaggagc gggctgagtc ggagcaggag gcctacctgc gtgaggattg     1140

agggcctgag cacactgccc tgtctcccca ctcagtgggg aaagcagggg cagatgccac     1200

cctgcccagg gttggcatga ctgtctgtgc accgagaaga ggcggcagat cctgccctgg     1260

ccaatcaggc gagacgcctt tgtgagctgt gagtgcctcc tgtggtctca ggcttgcgct     1320

ggacctggtt cttagccctt gggcactgca ccctgtttaa catttcaccc cactctgtac     1380

agctgctctt acccattttt tttacctcac acccaaagca ttttgcctac ctgggtcaga     1440

gagaggagtc ctttttgtca tgcccttaag ttcagcaact gtttaacctg ttttcagtct     1500

tatttacgtc gtcaaaaatg atttagtact tgttccctct gttgggatgc cagttgtggc     1560

agggggaggg gaacctgtcc agtttgtacg atttctttgt atgtatttct gatgtgttct     1620

ctgatctgcc cccactgtcc tgtgaggaca gctgaggcca aggagtgaaa aacctattac     1680

tactaagaga aggggtgcag agtgtttacc tggtgctctc aacaggactt aacatcaaca     1740

ggacttaaca caggcctctt gttccttcct ttctttccgt ttctctattg tatccaaagg     1800

agaagagtgt aagattttgt ttgcatctga aagagaaaat gcgtctctcc tggggtccta     1860

aaaaaaaaaa aaaaaaaaaa a                                               1881


<210>  12
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  12
aagcgguguu ucucagaauu g                                                 21


<210>  13
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  13
aacaauucug agaaacccgc                                                   20


<210>  14
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  14
gcagaucagg ccucuauaa                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  15
uuauagaggc cugaucugc                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  16
cccggaaagc agaaaccaa                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  17
uugguuucug cuuuccggg                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  18
gcuggcagaa gcacagaua                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  19
uaucugugcu ucugccagc                                                    19


<210>  20
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  20
aagcgguguu ucucagaauu gtt                                               23


<210>  21
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  21
aacaauucug agaaacccgc tt                                                22


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  22
gcagaucagg ccucuauaat t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  23
uuauagaggc cugaucugct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  24
cccggaaagc agaaaccaat t                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  25
uugguuucug cuuuccgggt t                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  26
gcuggcagaa gcacagauat t                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  27
uaucugugcu ucugccagct t                                                 21


<210>  28
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-modified guanine

<400>  28
aagcgguguu ucucagaauu gtt                                               23


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-modified guanine

<400>  29
aacaauucug agaaacccgc tt                                                22


<210>  30
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-modified guanine

<400>  30
aagcgguguu ucucagaauu gtt                                               23


<210>  31
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-modified guanine

<400>  31
aacaauucug agaaacccgc tt                                                22


<210>  32
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl-modified guanine

<400>  32
aagcgguguu ucucagaatt gtt                                               23


<210>  33
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-modified guanine

<400>  33
aacaauucug agaaacccgc tt                                                22


<210>  34
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl-modified guanine

<400>  34
aagcgguguu ucucagaatt gtt                                               23


<210>  35
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl-modified guanine

<400>  35
aacaauucug agaaacccgc tt                                                22


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-modified uridine

<400>  36
gcagaucagg ccucuauaat t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-modified guanine

<400>  37
uuauagaggc cugaucugct t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-modified uridine

<400>  38
gcagaucagg ccucuauaat t                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-modified guanine

<400>  39
uuauagaggc cugaucugct t                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl-modified uridine

<400>  40
gcagaucagg ccucuauaat t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-modified uridine

<400>  41
uuauagaggc cugaucugct t                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-modified uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl-modified uridine

<400>  42
gcagaucagg ccucuauaat t                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl-modified guanine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl-modified guanine

<400>  43
uuauagaggc cugaucugct t                                                 21


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  44
gcaaacaucc cagagguau                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  45
auaccucugg gauguuugc                                                    19


<210>  46
<211>  24
<212>  PRT
<213>  Synthetic peptide

<400>  46

Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu Thr 
1               5                   10                  15      


Leu Gly Glu Phe Leu Lys Leu Asp 
            20                  


<210>  47
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  47

Val Arg Phe Ile Thr Lys Ile Trp His Pro Asn Ile Ser Ser Val Thr 
1               5                   10                  15      


Gly Ala Ile Cys Leu Asp Ile Leu Lys 
            20                  25  


<210>  48
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  48

Leu Ile Arg Lys Asn Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val 
1               5                   10                  15      


Leu Pro Ile Leu Asp Asn Leu Leu Lys 
            20                  25  


<210>  49
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  49

Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys 
1               5                   10                  15      


Ala Asn Val Ile Asn Lys Gln Glu His 
            20                  25  


<210>  50
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  50

Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr Ser Pro Met Arg Asn 
1               5                   10                  15      


Ser Phe Ala His Ser Leu Ser Pro Thr 
            20                  25  


<210>  51
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  51

Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys 
1               5                   10                  15      


Glu Ile Asp Ser Thr Leu Tyr Lys Asn 
            20                  25  


<210>  52
<211>  26
<212>  PRT
<213>  Synthetic peptide

<400>  52

Phe Val Asp Lys Asn Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly 
1               5                   10                  15      


Leu Ser Leu Glu Glu Gln Leu Arg Arg Leu 
            20                  25      


<210>  53
<211>  27
<212>  PRT
<213>  Synthetic peptide

<400>  53

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys 
            20                  25          


<210>  54
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  54

Asp Gly Cys Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His 
1               5                   10                  15      


Val Lys Thr Cys Gly Lys Cys Arg Val 
            20                  25  


<210>  55
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  55

Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser Arg 
1               5                   10                  15      


Tyr Gly Tyr Lys Met Cys Leu Arg Ile 
            20                  25  


<210>  56
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  56

His Leu Ser Leu Phe Phe Val Val Met Lys Gly Pro Asn Asp Ala Leu 
1               5                   10                  15      


Leu Arg Trp Pro Phe Asn Gln Lys Val 
            20                  25  


<210>  57
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  57

Gly Ala Gly Leu Leu Gly Gly Gly Ser Val Thr Pro Arg Val His Ser 
1               5                   10                  15      


Ala Ile Val Glu Arg Leu Arg Ala Arg 
            20                  25  


<210>  58
<211>  24
<212>  PRT
<213>  Synthetic peptide

<400>  58

Gln Gln Gln Gln Gln Gln Gln Pro Ser Ser Gln Pro Ala Gln Ser Leu 
1               5                   10                  15      


Pro Ser Gln Pro Leu Leu Arg Ser 
            20                  


<210>  59
<211>  26
<212>  PRT
<213>  Synthetic peptide

<400>  59

Ser Ser Gln Pro Ala Gln Ser Leu Pro Ser Gln Pro Leu Leu Arg Ser 
1               5                   10                  15      


Pro Leu Pro Leu Gln Gln Lys Leu Leu Leu 
            20                  25      


<210>  60
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  60

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn 
            20                  25  


<210>  61
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  61

Val Ser His Met Lys Ser Leu Arg Gly Thr Gly Asn Thr Ser Thr Asp 
1               5                   10                  15      


Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
            20                  25  


<210>  62
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  62

Asp Val Asp Lys Leu Arg Glu Gln Leu Ser Thr Ser Glu Asn Ala Leu 
1               5                   10                  15      


Thr Gly Arg Ile Leu Asp Leu Lys Thr 
            20                  25  


<210>  63
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  63

Gly Asp Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly 
1               5                   10                  15      


Cys Lys Gly Phe Phe Lys Arg Thr Val 
            20                  25  


<210>  64
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  64

Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly Glu Pro Gln 
1               5                   10                  15      


Pro Ala Ser Cys Leu Ser Arg Leu Leu 
            20                  25  


<210>  65
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  65

Ala Val Ala Gly Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu 
1               5                   10                  15      


Gly Lys Leu Pro Glu Leu Arg Thr Leu 
            20                  25  


<210>  66
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  66

Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly 
1               5                   10                  15      


Pro Gln Asp Arg Leu Arg Ala Leu Val 
            20                  25  


<210>  67
<211>  25
<212>  PRT
<213>  Synthetic peptide

<400>  67

Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr Pro Asp 
1               5                   10                  15      


Leu Arg Ala Leu Leu Thr Ser Gly Thr 
            20                  25  


<210>  68
<211>  4
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Arg

<400>  68

Arg Xaa Arg Lys 
1               


<210>  69
<211>  28
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D-Arg

<400>  69

Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu Thr 
1               5                   10                  15      


Leu Gly Glu Phe Leu Lys Leu Asp Arg Xaa Arg Lys 
            20                  25              


<210>  70
<211>  29
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  D-Arg

<400>  70

Leu Ile Arg Lys Asn Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val 
1               5                   10                  15      


Leu Pro Ile Leu Asp Asn Leu Leu Lys Arg Xaa Arg Lys 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Arg

<400>  71

Arg Xaa Arg Lys Leu Ile Arg Lys Asn Arg Met Ala Leu Phe Gln Gln 
1               5                   10                  15      


Leu Thr Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys 
            20                  25                  


<210>  72
<211>  4
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-Arg

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  72

Xaa Xaa Xaa Phe 
1               


<210>  73
<211>  28
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  D-Arg

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Ornithine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Phenyl alanine with C-terminal amide group

<400>  73

Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu Thr 
1               5                   10                  15      


Leu Gly Glu Phe Leu Lys Leu Asp Xaa Xaa Xaa Phe 
            20                  25              


<210>  74
<211>  29
<212>  PRT
<213>  Sythetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-Arg

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  74

Xaa Xaa Xaa Phe Val Arg Phe Ile Thr Lys Ile Trp His Pro Asn Ile 
1               5                   10                  15      


Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu Lys 
            20                  25                  


<210>  75
<211>  41
<212>  PRT
<213>  Synthetic peptide

<400>  75

Met Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Val Arg Phe Ile Thr Lys Ile Trp His Pro Asn Ile Ser Ser Val Thr 
            20                  25                  30          


Gly Ala Ile Cys Leu Asp Ile Leu Lys 
        35                  40      


<210>  76
<211>  31
<212>  PRT
<213>  Synthetic peptide

<400>  76

His Ala Ile Tyr Pro Arg Leu Ile Arg Lys Asn Arg Met Ala Leu Phe 
1               5                   10                  15      


Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys 
            20                  25                  30      


<210>  77
<211>  6
<212>  PRT
<213>  Synthetic peptide

<400>  77

His Ala Ile Tyr Pro Arg 
1               5       


<210>  78
<211>  16
<212>  PRT
<213>  Synthetic peptide

<400>  78

Met Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


<210>  79
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  79
actcttccag ccttccttcc                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  80
tgttggcgta caggtctttg                                                   20


<210>  81
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  81
ctgacttcta cttccaggct gtt                                               23


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  82
gctcctatga tcacctgcca                                                   20


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  83
gcacggatct ttacttttgg g                                                 21


<210>  84
<211>  18
<212>  DNA
<213>  Artificial seqence

<220>
<223>  Primer

<400>  84
gggtcttcac tgggcttc                                                     18


<210>  85
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  85
atctagtgtt ccagttcagc c                                                 21


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  86
accacttggc atgttctacc                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  87
catgccaagt ggtttccaag                                                   20


<210>  88
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  88
tctgcatttt catctcctgg g                                                 21


<210>  89
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  89
aagcacgctc taacatctgg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  90
ttctccagcc aatcttccac                                                   20


<210>  91
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  91
tttggatcca atgggtgatg ttgag                                             25


<210>  92
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  92
ttgaattcct cattagtagc ttttttgag                                         29


<210>  93
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  93
ggagctgctc ttccgaatta                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  94
gcaggttcat gtcatcatcc                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  95
ctagtttgcc cacacccagt                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  96
tgctcaaaga tgtcgtccag                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  97
aggactctag acggcatcca                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  98
tgacagccag tgagacttgg                                                   20


<210>  99
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  99
ctttgggtgc gacttgacg                                                    19


<210>  100
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  100
gtcgaccccg ctcctttt                                                     18


<210>  101
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  101
ctcaatatta gagtctcaac cccca                                             25


<210>  102
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  102
aaggcgcttg tggagaagg                                                    19


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  103
gcttttgtca gcgatggagt                                                   20


<210>  104
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  104
tctgctaatg acgttatcca gtt                                               23


<210>  105
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  105
cagtgatgat aggataaagg aggga                                             25


<210>  106
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  106
catcatgagc ccgtccgc                                                     18


<210>  107
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  107
taaacgtagt gtccacggca                                                   20


<210>  108
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  108
tttccacacg cttatctgcg a                                                 21


<210>  109
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  109
tcaacctccc aagtagctgg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  110
ttaggaggcc aagacaggtg                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  111
ctcctgtgcc tgatgattgc                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  112
aactgatgcg tgaagtgctg                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  113
tggcacagtc taccggaaat                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  114
cctgagagtg gaatggtggt                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  115
ggcttcttct ctcccacagt                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  116
ttcttggttt gatgccggtg                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  117
ggagaagaca ccaccatcca                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  118
tcccaggttg attcagtccc                                                   20


