                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> TREM2 MUTANTS RESISTANT TO SHEDDASE CLEAVAGE

<130> PAT057836-WO-PCT

<140>
<141>

<150> 62/537,486
<151> 2017-07-27

<160> 89    

<170> PatentIn version 3.5

<210> 1
<211> 230
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 2
<211> 1076
<212> DNA
<213> Homo sapiens

<400> 2
gggcagcgcc tgacatgcct gatcctctct tttctgcagt tcaagggaaa gacgagatct       60

tgcacaaggc actctgcttc tgcccttggc tggggaaggg tggcatggag cctctccggc      120

tgctcatctt actctttgtc acagagctgt ccggagccca caacaccaca gtgttccagg      180

gcgtggcggg ccagtccctg caggtgtctt gcccctatga ctccatgaag cactggggga      240

ggcgcaaggc ctggtgccgc cagctgggag agaagggccc atgccagcgt gtggtcagca      300

cgcacaactt gtggctgctg tccttcctga ggaggtggaa tgggagcaca gccatcacag      360

acgataccct gggtggcact ctcaccatta cgctgcggaa tctacaaccc catgatgcgg      420

gtctctacca gtgccagagc ctccatggca gtgaggctga caccctcagg aaggtcctgg      480

tggaggtgct ggcagacccc ctggatcacc gggatgctgg agatctctgg ttccccgggg      540

agtctgagag cttcgaggat gcccatgtgg agcacagcat ctccaggagc ctcttggaag      600

gagaaatccc cttcccaccc acttccatcc ttctcctcct ggcctgcatc tttctcatca      660

agattctagc agccagcgcc ctctgggctg cagcctggca tggacagaag ccagggacac      720

atccacccag tgaactggac tgtggccatg acccagggta tcagctccaa actctgccag      780

ggctgagaga cacgtgaagg aagatgatgg gaggaaaagc ccaggagaag tcccaccagg      840

gaccagccca gcctgcatac ttgccacttg gccaccagga ctccttgttc tgctctggca      900

agagactact ctgcctgaac actgcttctc ctggaccctg gaagcaggga ctggttgagg      960

gagtggggag gtggtaagaa cacctgacaa cttctgaata ttggacattt taaacactta     1020

caaataaatc caagactgtc atatttagct ggataaaaaa aaaaaaaaaa aaaaaa         1076


<210> 3
<211> 219
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ala Glu Arg His Val Lys Glu Asp Asp Gly Arg Lys Ser Pro Gly 
                165                 170                 175     


Glu Val Pro Pro Gly Thr Ser Pro Ala Cys Ile Leu Ala Thr Trp Pro 
            180                 185                 190         


Pro Gly Leu Leu Val Leu Leu Trp Gln Glu Thr Thr Leu Pro Glu His 
        195                 200                 205             


Cys Phe Ser Trp Thr Leu Glu Ala Gly Thr Gly 
    210                 215                 


<210> 4
<211> 222
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Pro Ser Gln Gly Ser His Leu Pro Ser Cys Leu Ser Lys Glu Pro 
                165                 170                 175     


Leu Gly Arg Arg Asn Pro Leu Pro Thr His Phe His Pro Ser Pro Pro 
            180                 185                 190         


Gly Leu His Leu Ser His Gln Asp Ser Ser Ser Gln Arg Pro Leu Gly 
        195                 200                 205             


Cys Ser Leu Ala Trp Thr Glu Ala Arg Asp Thr Ser Thr Gln 
    210                 215                 220         


<210> 5
<211> 256
<212> PRT
<213> Macaca fascicularis

<400> 5
Met Pro Asp Pro Leu Phe Ser Ala Val Gln Gly Lys Asp Lys Ile Leu 
1               5                   10                  15      


His Lys Ala Leu Cys Ile Cys Pro Trp Pro Gly Lys Gly Gly Met Glu 
            20                  25                  30          


Pro Leu Arg Leu Leu Ile Leu Leu Phe Ala Thr Glu Leu Ser Gly Ala 
        35                  40                  45              


His Asn Thr Thr Val Phe Gln Gly Val Glu Gly Gln Ser Leu Gln Val 
    50                  55                  60                  


Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys Ala Trp 
65                  70                  75                  80  


Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val Ser Thr 
                85                  90                  95      


His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Arg Asn Gly Ser Thr 
            100                 105                 110         


Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr Leu Arg 
        115                 120                 125             


Asn Leu Gln Pro His Asp Ala Gly Phe Tyr Gln Cys Gln Ser Leu His 
    130                 135                 140                 


Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val Leu Ala 
145                 150                 155                 160 


Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Val Pro Gly Glu 
                165                 170                 175     


Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser Arg Ser 
            180                 185                 190         


Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Val Leu Leu Leu 
        195                 200                 205             


Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala Leu Trp 
    210                 215                 220                 


Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro Ser Glu 
225                 230                 235                 240 


Pro Asp Cys Gly His Asp Pro Gly His Gln Leu Gln Thr Leu Pro Gly 
                245                 250                 255     


<210> 6
<211> 227
<212> PRT
<213> Mus musculus

<400> 6
Met Gly Pro Leu His Gln Phe Leu Leu Leu Leu Ile Thr Ala Leu Ser 
1               5                   10                  15      


Gln Ala Leu Asn Thr Thr Val Leu Gln Gly Met Ala Gly Gln Ser Leu 
            20                  25                  30          


Arg Val Ser Cys Thr Tyr Asp Ala Leu Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Glu Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Gly Val Trp Leu Leu Ala Phe Leu Lys Lys Arg Asn Gly 
65                  70                  75                  80  


Ser Thr Val Ile Ala Asp Asp Thr Leu Ala Gly Thr Val Thr Ile Thr 
                85                  90                  95      


Leu Lys Asn Leu Gln Ala Gly Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu Arg Gly Arg Glu Ala Glu Val Leu Gln Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Glu Asp Pro Leu Asp Asp Gln Asp Ala Gly Asp Leu Trp Val Pro 
    130                 135                 140                 


Glu Glu Ser Ser Ser Phe Glu Gly Ala Gln Val Glu His Ser Thr Ser 
145                 150                 155                 160 


Arg Asn Gln Glu Thr Ser Phe Pro Pro Thr Ser Ile Leu Leu Leu Leu 
                165                 170                 175     


Ala Cys Val Leu Leu Ser Lys Phe Leu Ala Ala Ser Ile Leu Trp Ala 
            180                 185                 190         


Val Ala Arg Gly Arg Gln Lys Pro Gly Thr Pro Val Val Arg Gly Leu 
        195                 200                 205             


Asp Cys Gly Gln Asp Ala Gly His Gln Leu Gln Ile Leu Thr Gly Pro 
    210                 215                 220                 


Gly Gly Thr 
225         


<210> 7
<211> 62
<212> PRT
<213> Homo sapiens

<400> 7
Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
1               5                   10                  15      


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
            20                  25                  30          


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
        35                  40                  45              


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60          


<210> 8
<211> 57
<212> PRT
<213> Homo sapiens

<400> 8
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
        35                  40                  45              


Ser Arg Ala Glu Arg His Val Lys Glu 
    50                  55          


<210> 9
<211> 60
<212> PRT
<213> Homo sapiens

<400> 9
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
        35                  40                  45              


Ser Arg Pro Ser Gln Gly Ser His Leu Pro Ser Cys 
    50                  55                  60  


<210> 10
<211> 62
<212> PRT
<213> Macaca fascicularis

<400> 10
Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
1               5                   10                  15      


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Val Pro 
            20                  25                  30          


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
        35                  40                  45              


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60          


<210> 11
<211> 59
<212> PRT
<213> Mus musculus

<400> 11
Leu Arg Gly Arg Glu Ala Glu Val Leu Gln Lys Val Leu Val Glu Val 
1               5                   10                  15      


Leu Glu Asp Pro Leu Asp Asp Gln Asp Ala Gly Asp Leu Trp Val Pro 
            20                  25                  30          


Glu Glu Ser Ser Ser Phe Glu Gly Ala Gln Val Glu His Ser Thr Ser 
        35                  40                  45              


Arg Asn Gln Glu Thr Ser Phe Pro Pro Thr Ser 
    50                  55                  


<210> 12
<211> 41
<212> PRT
<213> Homo sapiens

<400> 12
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 13
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Leu Leu Leu Leu Ala Cys 
            20                  25  


<210> 14
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Ser Arg Ser Leu Leu Glu Gly Glu Ile Ile Leu Leu Leu 
            20                  25                  30          


Leu Ala Cys 
        35  


<210> 15
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Ser Arg Ser Leu Leu Glu Gly Thr Ser Ile Leu Leu Leu 
            20                  25                  30          


Leu Ala Cys 
        35  


<210> 16
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Ser Arg Ser Leu Phe Pro Pro Thr Ser Ile Leu Leu Leu 
            20                  25                  30          


Leu Ala Cys 
        35  


<210> 17
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu Leu Leu 
            20                  25                  30          


Leu Ala Cys 
        35  


<210> 18
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr 
1               5                   10                  15      


Gly Gly Trp Gly Gly Trp Gly Pro Glu Gly Glu Ile Pro Phe Pro Pro 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 19
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


His Ser Ile Ser Arg Ser Leu Leu Glu Gly Glu Ile Trp Phe Arg Trp 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 20
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr 
1               5                   10                  15      


Gly Gly Trp Gly Gly Trp Gly Pro Glu Gly Glu Ile Trp Phe Arg Trp 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 21
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


Ile Pro Asp Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 22
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


Ile Pro Pro Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 23
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu 
1               5                   10                  15      


Ile Asp Pro Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro 
            20                  25                  30          


Thr Ser Ile Leu Leu Leu Leu Ala Cys 
        35                  40      


<210> 24
<211> 60
<212> PRT
<213> Homo sapiens

<400> 24
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro 
    50                  55                  60  


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp 
            20  


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu Ser 
1               5                   10                  15      


Glu Ser Phe Glu 
            20  


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Asp Ala His Val Glu His Ser Ile Ser Arg Ser Leu Leu Glu Gly Glu 
1               5                   10                  15      


Ile Pro Phe Pro 
            20  


<210> 28
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Val Leu Val Glu Val Leu Ala Asp Pro Leu Asp His Arg Asp 
1               5                   10                  


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His 
1               5                   10          


<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Asp Ala His Val Glu Ile Pro Pro Ser Arg Ser Leu Leu Glu Gly Glu 
1               5                   10                  15      


Ile Pro Phe Pro 
            20  


<210> 31
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Asp Ala His Val Glu Ile Pro Asp Ser Arg Ser Leu Leu Glu Gly Glu 
1               5                   10                  15      


Ile Pro Phe Pro 
            20  


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Asp Ala His Val Glu Ile Asp Pro Ser Arg Ser Leu Leu Glu Gly Glu 
1               5                   10                  15      


Ile Pro Phe Pro 
            20  


<210> 33
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Pro Asp 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60              


<210> 34
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Pro Pro 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60              


<210> 35
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Asp Pro 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60              


<210> 36
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser 
        35                  40                  45          


<210> 37
<211> 57
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Glu 
        35                  40                  45              


Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55          


<210> 38
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr Gly Gly Trp 
        35                  40                  45              


Gly Gly Trp Gly Pro Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60              


<210> 39
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Trp Phe Arg Trp Thr Ser 
    50                  55                  60              


<210> 40
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr Gly Gly Trp 
        35                  40                  45              


Gly Gly Trp Gly Pro Glu Gly Glu Ile Trp Phe Arg Trp Thr Ser 
    50                  55                  60              


<210> 41
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Pro Asp Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 42
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Pro Pro Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 43
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu Ile Asp Pro Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 44
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Leu 
145                 150                 155                 160 


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
                165                 170                 175     


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
            180                 185                 190         


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
        195                 200                 205             


Pro Gly Leu Arg Asp Thr 
    210                 


<210> 45
<211> 224
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Glu Gly 
145                 150                 155                 160 


Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu Leu Leu Leu Ala Cys Ile 
                165                 170                 175     


Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala Leu Trp Ala Ala Ala Trp 
            180                 185                 190         


His Gly Gln Lys Pro Gly Thr His Pro Pro Ser Glu Leu Asp Cys Gly 
        195                 200                 205             


His Asp Pro Gly Tyr Gln Leu Gln Thr Leu Pro Gly Leu Arg Asp Thr 
    210                 215                 220                 


<210> 46
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr Gly Gly Trp Gly 
145                 150                 155                 160 


Gly Trp Gly Pro Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 47
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Trp Phe Arg Trp Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 48
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Tyr Gly Gly Trp Gly 
145                 150                 155                 160 


Gly Trp Gly Pro Glu Gly Glu Ile Trp Phe Arg Trp Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 49
<211> 113
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210> 50
<211> 608
<212> DNA
<213> Homo sapiens

<400> 50
agacttcctc cttcacttgc ctggacgctg cgccacatcc caccggccct tacactgtgg       60

tgtccagcag catccggctt catgggggga cttgaaccct gcagcaggct cctgctcctg      120

cctctcctgc tggctgtaag tggtctccgt cctgtccagg cccaggccca gagcgattgc      180

agttgctcta cggtgagccc gggcgtgctg gcagggatcg tgatgggaga cctggtgctg      240

acagtgctca ttgccctggc cgtgtacttc ctgggccggc tggtccctcg ggggcgaggg      300

gctgcggagg cagcgacccg gaaacagcgt atcactgaga ccgagtcgcc ttatcaggag      360

ctccagggtc agaggtcgga tgtctacagc gacctcaaca cacagaggcc gtattacaaa      420

tgagcccgaa tcatgacagt cagcaacatg atacctggat ccagccattc ctgaagccca      480

ccctgcacct cattccaact cctaccgcga tacagaccca cagagtgcca tccctgagag      540

accagaccgc tccccaatac tctcctaaaa taaacatgaa gcacaaaaac aaaaaaaaaa      600

aaaaaaaa                                                               608


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Ser Ile Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro 
1               5                   10                  


<210> 52
<211> 18
<212> PRT
<213> Thosea asigna virus

<400> 52
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 53
<211> 21
<212> PRT
<213> Thosea asigna virus

<400> 53
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 54
<211> 19
<212> PRT
<213> Porcine teschovirus-1

<400> 54
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 55
<211> 22
<212> PRT
<213> Porcine teschovirus-1

<400> 55
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 56
<211> 20
<212> PRT
<213> Equine rhinitis A virus

<400> 56
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 57
<211> 23
<212> PRT
<213> Equine rhinitis A virus

<400> 57
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 58
<211> 22
<212> PRT
<213> Foot-and-mouth disease virus

<400> 58
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210> 59
<211> 25
<212> PRT
<213> Foot-and-mouth disease virus

<400> 59
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 60
<211> 25
<212> PRT
<213> Strongylocentrotus purpuratus

<400> 60
Asp Gly Phe Cys Ile Leu Tyr Leu Leu Leu Ile Leu Leu Met Arg Ser 
1               5                   10                  15      


Gly Asp Val Glu Thr Asn Pro Gly Pro 
            20                  25  


<210> 61
<211> 20
<212> PRT
<213> Amphimedon queenslandica

<400> 61
Leu Leu Cys Phe Met Leu Leu Leu Leu Leu Ser Gly Asp Val Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 62
<211> 20
<212> PRT
<213> Amphimedon queenslandica

<400> 62
His His Phe Met Phe Leu Leu Leu Leu Leu Ala Gly Asp Ile Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 63
<211> 20
<212> PRT
<213> Saccoglossus kowalevskii

<400> 63
Trp Phe Leu Val Leu Leu Ser Phe Ile Leu Ser Gly Asp Ile Glu Val 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 64
<211> 20
<212> PRT
<213> Branchiostoma floridae

<400> 64
Lys Asn Cys Ala Met Tyr Met Leu Leu Leu Ser Gly Asp Val Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 65
<211> 20
<212> PRT
<213> Branchiostoma floridae

<400> 65
Met Val Ile Ser Gln Leu Met Leu Lys Leu Ala Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 66
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      2A consensus sequence"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 66
Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210> 67
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 67
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaaattcc ggatagccgc agcctgctgg aaggcgaaat tccgtttccg      180

ccgaccagc                                                              189


<210> 68
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 68
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaaattcc gccgagccgc agcctgctgg aaggcgaaat tccgtttccg      180

ccgaccagc                                                              189


<210> 69
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 69
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaaattga tccgagccgc agcctgctgg aaggcgaaat tccgtttccg      180

ccgaccagc                                                              189


<210> 70
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaacatag c                                                141


<210> 71
<211> 171
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 71
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaacatag cgaaggcgaa attccgtttc cgccgaccag c               171


<210> 72
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 72
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tgtatggcgg ctggggcggc tggggcccgg aaggcgaaat tccgtttccg      180

ccgaccagc                                                              189


<210> 73
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 73
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tggaacatag cattagccgc agcctgctgg aaggcgaaat ttggtttcgc      180

tggaccagc                                                              189


<210> 74
<211> 189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 74
agcctgcatg gcagcgaagc ggataccctg cgcaaagtgc tggtggaagt gctggcggat       60

ccgctggatc atcgcgatgc gggcgatctg tggtttccgg gcgaaagcga aagctttgaa      120

gatgcgcatg tgtatggcgg ctggggcggc tggggcccgg aaggcgaaat ttggtttcgc      180

tggaccagc                                                              189


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
gtaatgtgag agactttggg                                                   20


<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
ccgaagcccg ggtcatccgg                                                   20


<210> 77
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 77
attagacaat acttactggg gatcc                                             25


<210> 78
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 78
ggaagctctg gaggaatatg tg                                                22


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 79
cccccaaaca cctgatagac                                                   20


<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 80
ccagagaggt ggagtcggta                                                   20


<210> 81
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 81
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210> 82
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
gtctcgtggg ctcggagatg tgtataagag acag                                   34


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Leu Leu Glu Gly Glu Ile Pro Phe Pro 
1               5                   


<210> 84
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro 
1               5                   10          


<210> 85
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu Ser Glu Ser Phe Glu Asp 
1               5                   10                  15      


Ala His Val Glu His 
            20      


<210> 86
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser His His His 
1               5                   10                  15      


His His His 
            


<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 87
His Ser Ile Ser Arg Ser Leu Leu Glu 
1               5                   


<210> 88
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Gly Glu Ile Pro Phe Pro Pro Thr Ser His His His His His His 
1               5                   10                  15  


<210> 89
<211> 63
<212> PRT
<213> Homo sapiens

<400> 89
Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
1               5                   10                  15      


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
            20                  25                  30          


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
        35                  40                  45              


Ser Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
    50                  55                  60              



