                         SEQUENCE LISTING

<110>  Oxford Genetics Limited
 
<120>  Adenoviral Vectors

<130>  489.133740/02

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  DNA
<213>  Human adenovirus type 5

<400>  1
cgccctcttc ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg tgaccgggtg       60

ttcctgaagg ggggctataa aagggggtgg gggcgcgttc gtcctca                    107


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetR binding site

<400>  2
tccctatcag tgatagaga                                                    19


<210>  3
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetR

<400>  3
atgtcgcgcc tggacaaaag caaagtgatt aactcagcgc tggaactgtt gaatgaggtg       60

ggaattgaag gactcactac tcgcaagctg gcacagaagc tgggcgtcga gcagccaacg      120

ctgtactggc atgtgaagaa taaacgggcg ctcctagacg cgcttgccat cgaaatgctg      180

gaccgccatc acacccactt ttgccccctg gagggcgaat cctggcaaga ttttctgcgg      240

aacaatgcaa agtcgttccg gtgcgctctg ctgtcccacc gcgatggcgc aaaagtgcac      300

ctgggcactc ggcccaccga gaaacaatac gaaaccctgg aaaaccaact ggctttcctt      360

tgccaacagg gattttcact ggagaatgcc ctgtacgcac tatccgcggt cggccacttt      420

accctgggat gcgtcctcga agatcaggag caccaagtcg ccaaggagga aagagaaact      480

cctaccactg actcaatgcc tccgctcctg agacaagcca tcgagctgtt cgaccaccag      540

ggtgctgaac ctgcatttct gttcgggctt gaactgatta tctgcggcct ggagaaacag      600

ttgaagtgcg agtcgggatc ctag                                             624


<210>  4
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR

<400>  4

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opposite TetR binding site

<400>  5

Glu Ser Leu Ser Leu Ile Gly Thr 
1               5               


<210>  6
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified MLP

<400>  6
cgccctcttc ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg tgaccgggtg       60

ttcctgaagg ggggctataa aaggtcccta tcagtgatag agactca                    107


<210>  7
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified MLP

<400>  7
cgccctcttc ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg tgactcccta       60

tcagtgatag agaactataa aaggtcccta tcagtgatag agactca                    107


<210>  8
<211>  416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence in viral vector or other sequence

<400>  8
aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca       60

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt      120

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag gtccctatca      180

gtgatagaga ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt      240

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg      300

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt      360

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcg          416


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5 fiber forward primer

<400>  9
tggctgttaa aggcagtttg g                                                 21


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5 fiber reverse primer

<400>  10
gcactccatt ttcgtcaaat ctt                                               23


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TaqMan probe

<400>  11
tccaatatct ggaacagttc aaagtgctca tct                                    33


<210>  12
<211>  173
<212>  PRT
<213>  Human adenovirus type 5

<400>  12

Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys 
1               5                   10                  15      


Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Met Asp Ala Ala Thr 
            20                  25                  30          


Leu Lys Gly Ile Thr Ala Gly Gln Val Asn Ile Lys Ser Ser Ser Phe 
        35                  40                  45              


Leu Glu Thr Asp Asn Leu Ser Ala Glu Val Met Pro Ala Phe Gln Arg 
    50                  55                  60                  


Glu Tyr Ser Pro Gln Gln Leu Ala Leu Ala Asp Ser Asp Ala Glu Glu 
65                  70                  75                  80  


Ser Glu Asp Glu Arg Ala Pro Thr Pro Phe Tyr Ser Pro Pro Ser Gly 
                85                  90                  95      


Thr Pro Gly His Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp 
            100                 105                 110         


Ala Glu Glu Gly Asp Met Cys Leu His Thr Leu Glu Arg Val Asp Pro 
        115                 120                 125             


Leu Val Asp Asn Asp Arg Tyr Pro Ser His Leu Ala Ser Phe Val Leu 
    130                 135                 140                 


Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Glu Phe Leu Tyr Glu 
145                 150                 155                 160 


Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Pro Leu Lys 
                165                 170             


<210>  13
<211>  390
<212>  DNA
<213>  Human adenovirus type 5

<400>  13
cactaggggg tccactcgct ccagggtgtg aagacacatg tcgccctctt cggcatcaag       60

gaaggtgatt ggtttgtagg tgtaggccac gtgaccgggt gttcctgaag gggggctata      120

aaagggggtg ggggcgcgtt cgtcctcact ctcttccgca tcgctgtctg cgagggccag      180

ctgttggggt gagtactccc tctgaaaagc gggcatgact tctgcgctaa gattgtcagt      240

ttccaaaaac gaggaggatt tgatattcac ctggcccgcg gtgatgcctt tgagggtggc      300

cgcatccatc tggtcagaaa agacaatctt tttgttgtca agcttggtgg caaacgaccc      360

gtagagggcg ttggacagca acttggcgat                                       390


<210>  14
<211>  390
<212>  DNA
<213>  Human adenovirus type 5

<400>  14
atcgccaagt tgctgtccaa cgccctctac gggtcgtttg ccaccaagct tgacaacaaa       60

aagattgtct tttctgacca gatggatgcg gccaccctca aaggcatcac cgcgggccag      120

gtgaatatca aatcctcctc gtttttggaa actgacaatc ttagcgcaga agtcatgccc      180

gcttttcaga gggagtactc accccaacag ctggccctcg cagacagcga tgcggaagag      240

agtgaggacg aacgcgcccc cacccccttt tatagccccc cttcaggaac acccggtcac      300

gtggcctaca cctacaaacc aatcaccttc cttgatgccg aagagggcga catgtgtctt      360

cacaccctgg agcgagtgga ccccctagtg                                       390


<210>  15
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MLP

<400>  15

Ala Lys Glu Arg Ala Asp Arg Asp Lys Asn Gln Thr Leu Arg Ser Ile 
1               5                   10                  15      


Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu 
            20                  25                  30          


Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Met Asp Ala Ala Thr Leu 
        35                  40                  45              


Lys Gly Ile Thr Ala Gly Gln Val Asn Ile Lys Ser Ser Ser Phe Leu 
    50                  55                  60                  


Glu Thr Asp Asn Leu Ser Ala Glu Val Met Pro Ala Phe Gln Arg Glu 
65                  70                  75                  80  


Tyr Ser Pro Gln Gln Leu Ala Leu Ala Asp Ser Asp Ala Glu Glu Ser 
                85                  90                  95      


Glu Ser Leu Ser Leu Ile Gly Thr Phe Tyr Ser Pro Pro Ser Gly Thr 
            100                 105                 110         


Pro Gly His Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Ala 
        115                 120                 125             


Glu Glu Gly Asp Met Cys Leu His Thr Leu Glu Arg Val Asp Pro Leu 
    130                 135                 140                 


Val Asp Asn Asp Arg Tyr Pro Ser His Leu Ala Ser Phe Val Leu Ala 
145                 150                 155                 160 


<210>  16
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified MLP

<400>  16
aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca       60

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt      120

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag gtccctatca      180

gtgatagaga ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt      240

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg      300

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt      360

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg      420

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg      480


<210>  17
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified MLP

<400>  17
ccaaggagcg cgccgatcgc gacaaaaacc aaaccctgcg ctccatcgcc aagttgctgt       60

ccaacgccct ctacgggtcg tttgccacca agcttgacaa caaaaagatt gtcttttctg      120

accagatgga tgcggccacc ctcaaaggca tcaccgcggg ccaggtgaat atcaaatcct      180

cctcgttttt ggaaactgac aatcttagcg cagaagtcat gcccgctttt cagagggagt      240

actcacccca acagctggcc ctcgcagaca gcgatgcgga agagagtgag tctctatcac      300

tgatagggac cttttatagc cccccttcag gaacacccgg tcacgtggcc tacacctaca      360

aaccaatcac cttccttgat gccgaagagg gcgacatgtg tcttcacacc ctggagcgag      420

tggaccccct agtggacaac gaccgctacc cctcccactt agcctccttc gtgctggcct      480


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNA polymerase coding sequence between MLP TATA box and +1

<400>  18

Glu Asn Glu Arg Ala Pro Thr Pro 
1               5               


