               SEQUENCE LISTING

<110> Biouniversa S.r.l.

<120> Ab Anti-BAG3 as therapeutic reagent in cardiovascular diseases

<150> IT102017000087307
<151> 2017-07-28
<150> IT102017000113648
<151> 2017-10-10

<160> 26

<170> BiSSAP 1.2

<210> 1
<211> 16
<212> PRT
<213> Homo sapiens


<400> 1
Asp Arg Asp Pro Leu Pro Pro Gly Trp Glu Ile Lys Ile Asp Pro Gln 
1               5                   10                  15      



<210> 2
<211> 15
<212> PRT
<213> Homo sapiens


<400> 2
Ser Ser Pro Lys Ser Val Ala Thr Glu Glu Arg Ala Ala Pro Ser 
1               5                   10                  15  

<210> 3
<211> 15
<212> PRT
<213> Homo sapiens


<400> 3
Asp Lys Gly Lys Lys Asn Ala Gly Asn Ala Glu Asp Pro His Thr 
1               5                   10                  15  

<210> 4
<211> 15
<212> PRT
<213> Homo sapiens


<400> 4
Asn Pro Ser Ser Met Thr Asp Thr Pro Gly Asn Pro Ala Ala Pro 
1               5                   10                  15  

<210> 5
<211> 10
<212> PRT
<213> Homo sapiens


<400> 5
Gly Phe Asn Ile Lys Asp Thr Tyr Met Tyr 
1               5                   10  

<210> 6
<211> 17
<212> PRT
<213> Homo sapiens


<400> 6
Gly Val Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 7
<211> 6
<212> PRT
<213> Homo sapiens


<400> 7
Asp Gly Ala Met Asp Tyr 
1               5       

<210> 8
<211> 17
<212> PRT
<213> Homo sapiens


<400> 8
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 9
<211> 7
<212> PRT
<213> Homo sapiens


<400> 9
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 10
<211> 9
<212> PRT
<213> Homo sapiens


<400> 10
Gln Gln Tyr Tyr Thr Tyr Pro Leu Thr 
1               5                   

<210> 11
<211> 1416
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1416
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 11
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtcagg tgcagctggt ccagagcggg gcagaggtga agaaaccagg tgccagcgtg     120

aaggtctctt gcaaagccag tggcttcaac atcaaggaca catacatgta ttgggtgcga     180

caggcccctg gccagggtct ggaatggatg ggcggcgtgg accccgcaaa tggaaatact     240

agatacgatc ctaaatttca gggaagggtg accatgacac gggacacttc aacctcgacg     300

gtctatatgg agctgtccag cctgagatcc gaagatacag ccgtgtacta ttgtgcccgc     360

gacggggcta tggattactg gggccaggga actctggtga ccgtctcgag cgctagcaca     420

aagggcccta gtgtgtttcc tctggctccc tcttccaaat ccacttctgg tggcactgct     480

gctctgggat gcctggtgaa ggattacttt cctgaacctg tgactgtctc atggaactct     540

ggtgctctga cttctggtgt ccacactttc cctgctgtgc tgcagtctag tggactgtac     600

tctctgtcat ctgtggtcac tgtgccctct tcatctctgg gaacccagac ctacatttgt     660

aatgtgaacc acaaaccatc caacactaaa gtggacaaaa aagtggaacc caaatcctgt     720

gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg     780

tttctgttcc cccccaaacc aaaggatacc ctgatgatct ctagaacccc tgaggtgaca     840

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat     900

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac     960

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag    1020

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag    1080

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa    1140

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag    1200

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct    1260

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg    1320

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc    1380

ctgtctctgt ctcccgggaa atgatagtaa aagctt                              1416


<210> 12
<211> 445
<212> PRT
<213> Homo sapiens


<400> 12
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Val Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 13
<211> 1416
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1416
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 13
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtcagg tgcagctggt ccagtctgga gctgaggtga agaaaccagg agcctccgtg     120

aaggtctctt gcaaagccag tggcttcaac atcaaggaca catacatgta ttgggtgcga     180

caggcccctg gccagggtct ggaatggatg ggcggcgtgg accccgcaaa tggaaatact     240

agatacgatc ctaaatttca aggcagggtg accctgacac gggacacttc aacctcgacg     300

gtctatatgg agctgtccag cctgagatcc gaagatacag cagtgtacta ttgtgggcgc     360

gacggtgcta tggactactg gggccaggga actctggtga ccgtctcgag cgctagcaca     420

aagggcccta gtgtgtttcc tctggctccc tcttccaaat ccacttctgg tggcactgct     480

gctctgggat gcctggtgaa ggattacttt cctgaacctg tgactgtctc atggaactct     540

ggtgctctga cttctggtgt ccacactttc cctgctgtgc tgcagtctag tggactgtac     600

tctctgtcat ctgtggtcac tgtgccctct tcatctctgg gaacccagac ctacatttgt     660

aatgtgaacc acaaaccatc caacactaaa gtggacaaaa aagtggaacc caaatcctgt     720

gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg     780

tttctgttcc cccccaaacc aaaggatacc ctgatgatct ctagaacccc tgaggtgaca     840

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat     900

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac     960

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag    1020

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag    1080

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa    1140

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag    1200

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct    1260

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg    1320

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc    1380

ctgtctctgt ctcccgggaa atgatagtaa aagctt                              1416


<210> 14
<211> 445
<212> PRT
<213> Homo sapiens


<400> 14
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Val Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Gly Arg Asp Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 15
<211> 1416
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1416
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 15
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtcagg tgcagctggt ccagtctgga gctgaggtga agaaaccagg agcctccgtg     120

aaggtctctt gcacagctag tggcttcaac atcaaggaca cttacatgta ttgggtgaaa     180

caggcccctg gccagggtct ggaatggatt ggcggcgtgg accccgcaaa cgggaatacc     240

agatacgatc ctaagtttca aggcaaagcc accctgacaa gggacacttc aacctcgacg     300

gtgtatatgg agctgtccag cctgaggtcc gaagatacag cagtgtacta ttgtgggcgg     360

gacggtgcta tggactactg gggccaggga actctggtga ccgtctcgag cgctagcaca     420

aagggcccta gtgtgtttcc tctggctccc tcttccaaat ccacttctgg tggcactgct     480

gctctgggat gcctggtgaa ggattacttt cctgaacctg tgactgtctc atggaactct     540

ggtgctctga cttctggtgt ccacactttc cctgctgtgc tgcagtctag tggactgtac     600

tctctgtcat ctgtggtcac tgtgccctct tcatctctgg gaacccagac ctacatttgt     660

aatgtgaacc acaaaccatc caacactaaa gtggacaaaa aagtggaacc caaatcctgt     720

gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg     780

tttctgttcc cccccaaacc aaaggatacc ctgatgatct ctagaacccc tgaggtgaca     840

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat     900

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac     960

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag    1020

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag    1080

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa    1140

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag    1200

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct    1260

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg    1320

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc    1380

ctgtctctgt ctcccgggaa atgatagtaa aagctt                              1416


<210> 16
<211> 445
<212> PRT
<213> Homo sapiens


<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Met Tyr Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Gly Val Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Gly Arg Asp Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 17
<211> 1416
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1416
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 17
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtgagg tgcagctggt ccagagtggg gcagaagtga agaaaccagg tgccacagtg     120

aagatctcat gcaaagtctc cggcttcaac attaaggaca cttacatgta ttgggtgcag     180

caggcccccg gcaagggtct ggagtggatg ggcggcgtgg accccgctaa cggcaatacc     240

agatacgatc ctaagtttca aggacgggtg accatcacag ctgacactag caccgatacg     300

gcatatatgg agctgtccag cctgagatct gaagatacag cagtgtacta ttgtgccagg     360

gacggggcta tggattactg gggccaggga actctggtga ccgtctcgag cgctagcaca     420

aagggcccta gtgtgtttcc tctggctccc tcttccaaat ccacttctgg tggcactgct     480

gctctgggat gcctggtgaa ggattacttt cctgaacctg tgactgtctc atggaactct     540

ggtgctctga cttctggtgt ccacactttc cctgctgtgc tgcagtctag tggactgtac     600

tctctgtcat ctgtggtcac tgtgccctct tcatctctgg gaacccagac ctacatttgt     660

aatgtgaacc acaaaccatc caacactaaa gtggacaaaa aagtggaacc caaatcctgt     720

gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg     780

tttctgttcc cccccaaacc aaaggatacc ctgatgatct ctagaacccc tgaggtgaca     840

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat     900

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac     960

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag    1020

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag    1080

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa    1140

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag    1200

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct    1260

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg    1320

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc    1380

ctgtctctgt ctcccgggaa atgatagtaa aagctt                              1416


<210> 18
<211> 445
<212> PRT
<213> Homo sapiens


<400> 18
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Met Tyr Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Val Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 19
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..741
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 19
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtgaca tcgtgatgac acagtcacct gattccctgg cagtcagtct gggcgagaga     120

gccactatta actgcaagtc cagccagtct ctgctgtact ctagtaacca gaaaaattac     180

ctggcttggt atcagcagaa gccagggcag ccccctaaac tgctgatcta ttgggcaagc     240

accagggaat ctggagtgcc cgaccggttc agcggttctg gcagtggaac agattttacc     300

ctgacaattt catccctgca agccgaggac gtggctgtct actattgtca gcagtactat     360

acttacccac tgaccttcgg cggagggacc aagctcgaga tcaaacgtac ggtcgcggcg     420

ccttctgtgt tcattttccc cccatctgat gaacagctga aatctggcac tgcttctgtg     480

gtctgtctgc tgaacaactt ctaccctaga gaggccaaag tccagtggaa agtggacaat     540

gctctgcaga gtgggaattc ccaggaatct gtcactgagc aggactctaa ggatagcaca     600

tactccctgt cctctactct gacactgagc aaggctgatt acgagaaaca caaagtgtac     660

gcctgtgaag tcacacatca ggggctgtct agtcctgtga ccaaatcctt caatagggga     720

gagtgctgat agtaaaagct t                                               741


<210> 20
<211> 220
<212> PRT
<213> Homo sapiens


<400> 20
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 21
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..741
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 21
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtgaca tcgtgatgac acagtcacct gattccctgg cagtcagtct gggcgagaga     120

gccactatta actgcaagtc cagccagtct ctgctgtact ctagtaacca gaaaaattat     180

ctggcttggc accagcagaa gccagggcag ccccctaaac tgctgatcta ctgggcaagc     240

accagggaat ctggagtgcc cgaccggttc agcggttctg gcagtggaac agattttacc     300

ctgacaattt catccctgca agccgaggac gtggctgtct actattgtca gcagtactat     360

acttatccac tgaccttcgg cggagggacc aagctcgaga tcaaacgtac ggtcgcggcg     420

ccttctgtgt tcattttccc cccatctgat gaacagctga aatctggcac tgcttctgtg     480

gtctgtctgc tgaacaactt ctaccctaga gaggccaaag tccagtggaa agtggacaat     540

gctctgcaga gtgggaattc ccaggaatct gtcactgagc aggactctaa ggatagcaca     600

tactccctgt cctctactct gacactgagc aaggctgatt acgagaaaca caaagtgtac     660

gcctgtgaag tcacacatca ggggctgtct agtcctgtga ccaaatcctt caatagggga     720

gagtgctgat agtaaaagct t                                               741


<210> 22
<211> 220
<212> PRT
<213> Homo sapiens


<400> 22
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp His Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 23
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..741
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 23
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtgaca tcgtgatgac acagtcacct gattccctgg cagtctccct gggcgagaga     120

gccactatga gttgcaagtc cagccagtct ctgctgtact ctagtaacca gaaaaattat     180

ctggcttggc accagcagaa gccagggcag ccccctaaac tgctgatcta ctgggcaagc     240

accagggaat ctggagtgcc cgaccggttc agcggttctg gcagtggaac agattttacc     300

ctgacaattt catccctgca agccgaggac gtggctgtct actattgtca gcagtactat     360

acttatccac tgaccttcgg cggagggacc aagctcgaga tcaagcgtac ggtcgcggcg     420

ccttctgtgt tcattttccc cccatctgat gaacagctga aatctggcac tgcttctgtg     480

gtctgtctgc tgaacaactt ctaccctaga gaggccaaag tccagtggaa agtggacaat     540

gctctgcaga gtgggaattc ccaggaatct gtcactgagc aggactctaa ggatagcaca     600

tactccctgt cctctactct gacactgagc aaggctgatt acgagaaaca caaagtgtac     660

gcctgtgaag tcacacatca ggggctgtct agtcctgtga ccaaatcctt caatagggga     720

gagtgctgat agtaaaagct t                                               741


<210> 24
<211> 220
<212> PRT
<213> Homo sapiens


<400> 24
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp His Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 25
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..741
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 25
gcggccgcca tgaattttgg actgaggctg attttcctgg tgctgaccct gaaaggcgtc      60

cagtgtgaca tcgtgatgac acagtcacct gattccctgg cagtctccct gggcgagaga     120

gccactatga gttgcaagtc cagccagtct ctgctgtact ctagtaacca gaaaaattat     180

ctggcttggc accagcagaa gccaggacag ccccctaaac tgctgatcta ctgggcaagc     240

accagggaat ctggcgtgcc cgaccggttc agcggctctg gaagtgggac agattttacc     300

ctgacaatct catccctgca agccgaggac ctggctatct actattgtca gcagtactat     360

acttatccac tgaccttcgg tgccggcacc aagctcgaga tcaaacgtac ggtcgcggcg     420

ccttctgtgt tcattttccc cccatctgat gaacagctga aatctggcac tgcttctgtg     480

gtctgtctgc tgaacaactt ctaccctaga gaggccaaag tccagtggaa agtggacaat     540

gctctgcaga gtgggaattc ccaggaatct gtcactgagc aggactctaa ggatagcaca     600

tactccctgt cctctactct gacactgagc aaggctgatt acgagaaaca caaagtgtac     660

gcctgtgaag tcacacatca ggggctgtct agtcctgtga ccaaatcctt caatagggga     720

gagtgctgat agtaaaagct t                                               741


<210> 26
<211> 220
<212> PRT
<213> Homo sapiens


<400> 26
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp His Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

