﻿               SEQUENCE LISTING

<110> ENCEFA
      TOULORGE Damien
      GUERREIRO DA SILVA Serge
      BRESSAC Laurence

<120> COMPOUNDS WHICH SPECIFICALLY BIND TO CD38
      FOR USE IN THE TREATMENT OF
      NEURODEGENERATIVE AND INFLAMMATORY DISEASES

<130> CV – 1069/PCT

<160> 3

<170> BiSSAP 1.3.6

<210> 1
<211> 300
<212> PRT
<213> Homo sapiens


<220> 
<223> Human CD38

<400> 1
Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      
Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          
Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              
Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  
Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  
Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      
His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         
Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             
Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 
Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 
Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     
Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         
Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             
Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 
Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 
Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     
Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         
Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             
Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 

<210> 2
<211> 888
<212> PRT
<213> Homo sapiens


<220> 
<223> Human NAADP receptor Two Pore Channels TPC1

<400> 2
Met Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      
Ser Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp 
            20                  25                  30          
Ala Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe 
        35                  40                  45              
Glu Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile 
    50                  55                  60                  
Leu Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp 
65                  70                  75                  80  
Val Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala 
                85                  90                  95      
Pro Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly 
            100                 105                 110         
Ser Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly 
        115                 120                 125             
Glu Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln 
    130                 135                 140                 
Glu Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe 
145                 150                 155                 160 
Thr His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His 
                165                 170                 175     
Asn His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu 
            180                 185                 190         
Leu Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly 
        195                 200                 205             
Ile Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val 
    210                 215                 220                 
Phe Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile 
225                 230                 235                 240 
Arg His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe 
                245                 250                 255     
Val Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val 
            260                 265                 270         
Thr Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly 
        275                 280                 285             
Gly Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe 
    290                 295                 300                 
Met Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile 
305                 310                 315                 320 
Leu Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser 
                325                 330                 335     
Thr Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala 
            340                 345                 350         
Asn Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser 
        355                 360                 365             
Cys Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met 
    370                 375                 380                 
Asn Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys 
385                 390                 395                 400 
Arg Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His 
                405                 410                 415     
Ala Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr 
            420                 425                 430         
Arg Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala 
        435                 440                 445             
Arg Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro 
    450                 455                 460                 
Leu Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu 
465                 470                 475                 480 
Lys Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro 
                485                 490                 495     
Arg Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser 
            500                 505                 510         
Lys Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val 
        515                 520                 525             
Trp Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser 
    530                 535                 540                 
Lys His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val 
545                 550                 555                 560 
Glu Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser 
                565                 570                 575     
Ser Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu 
            580                 585                 590         
Gly Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val 
        595                 600                 605             
Val Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg 
    610                 615                 620                 
Tyr Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala 
625                 630                 635                 640 
Ser Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val 
                645                 650                 655     
Gly Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr 
            660                 665                 670         
Ser Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn 
        675                 680                 685             
Arg Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn 
    690                 695                 700                 
Ile Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn 
705                 710                 715                 720 
Trp Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser 
                725                 730                 735     
Arg Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr 
            740                 745                 750         
Ile Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr 
        755                 760                 765             
Ser Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu 
    770                 775                 780                 
Lys Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg 
785                 790                 795                 800 
Glu Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu 
                805                 810                 815     
Ser Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg 
            820                 825                 830         
Arg Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu 
        835                 840                 845             
Ile Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg 
    850                 855                 860                 
Gln Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser 
865                 870                 875                 880 
Arg Gln Arg Ser Gln Thr Val Thr 
                885             

<210> 3
<211> 752
<212> PRT
<213> Homo sapiens


<220> 
<223> Human NAADP receptor Two Pore Channels TPC2

<400> 3
Met Ala Glu Pro Gln Ala Glu Ser Glu Pro Leu Leu Gly Gly Ala Arg 
1               5                   10                  15      
Gly Gly Gly Gly Asp Trp Pro Ala Gly Leu Thr Thr Tyr Arg Ser Ile 
            20                  25                  30          
Gln Val Gly Pro Gly Ala Ala Ala Arg Trp Asp Leu Cys Ile Asp Gln 
        35                  40                  45              
Ala Val Val Phe Ile Glu Asp Ala Ile Gln Tyr Arg Ser Ile Asn His 
    50                  55                  60                  
Arg Val Asp Ala Ser Ser Met Trp Leu Tyr Arg Arg Tyr Tyr Ser Asn 
65                  70                  75                  80  
Val Cys Gln Arg Thr Leu Ser Phe Thr Ile Phe Leu Ile Leu Phe Leu 
                85                  90                  95      
Ala Phe Ile Glu Thr Pro Ser Ser Leu Thr Ser Thr Ala Asp Val Arg 
            100                 105                 110         
Tyr Arg Ala Ala Pro Trp Glu Pro Pro Cys Gly Leu Thr Glu Ser Val 
        115                 120                 125             
Glu Val Leu Cys Leu Leu Val Phe Ala Ala Asp Leu Ser Val Lys Gly 
    130                 135                 140                 
Tyr Leu Phe Gly Trp Ala His Phe Gln Lys Asn Leu Trp Leu Leu Gly 
145                 150                 155                 160 
Tyr Leu Val Val Leu Val Val Ser Leu Val Asp Trp Thr Val Ser Leu 
                165                 170                 175     
Ser Leu Val Cys His Glu Pro Leu Arg Ile Arg Arg Leu Leu Arg Pro 
            180                 185                 190         
Phe Phe Leu Leu Gln Asn Ser Ser Met Met Lys Lys Thr Leu Lys Cys 
        195                 200                 205             
Ile Arg Trp Ser Leu Pro Glu Met Ala Ser Val Gly Leu Leu Leu Ala 
    210                 215                 220                 
Ile His Leu Cys Leu Phe Thr Met Phe Gly Met Leu Leu Phe Ala Gly 
225                 230                 235                 240 
Gly Lys Gln Asp Asp Gly Gln Asp Arg Glu Arg Leu Thr Tyr Phe Gln 
                245                 250                 255     
Asn Leu Pro Glu Ser Leu Thr Ser Leu Leu Val Leu Leu Thr Thr Ala 
            260                 265                 270         
Asn Asn Pro Asp Val Met Ile Pro Ala Tyr Ser Lys Asn Arg Ala Tyr 
        275                 280                 285             
Ala Ile Phe Phe Ile Val Phe Thr Val Ile Gly Ser Leu Phe Leu Met 
    290                 295                 300                 
Asn Leu Leu Thr Ala Ile Ile Tyr Ser Gln Phe Arg Gly Tyr Leu Met 
305                 310                 315                 320 
Lys Ser Leu Gln Thr Ser Leu Phe Arg Arg Arg Leu Gly Thr Arg Ala 
                325                 330                 335     
Ala Phe Glu Val Leu Ser Ser Met Val Gly Glu Gly Gly Ala Phe Pro 
            340                 345                 350         
Gln Ala Val Gly Val Lys Pro Gln Asn Leu Leu Gln Val Leu Gln Lys 
        355                 360                 365             
Val Gln Leu Asp Ser Ser His Lys Gln Ala Met Met Glu Lys Val Arg 
    370                 375                 380                 
Ser Tyr Gly Ser Val Leu Leu Ser Ala Glu Glu Phe Gln Lys Leu Phe 
385                 390                 395                 400 
Asn Glu Leu Asp Arg Ser Val Val Lys Glu His Pro Pro Arg Pro Glu 
                405                 410                 415     
Tyr Gln Ser Pro Phe Leu Gln Ser Ala Gln Phe Leu Phe Gly His Tyr 
            420                 425                 430         
Tyr Phe Asp Tyr Leu Gly Asn Leu Ile Ala Leu Ala Asn Leu Val Ser 
        435                 440                 445             
Ile Cys Val Phe Leu Val Leu Asp Ala Asp Val Leu Pro Ala Glu Arg 
    450                 455                 460                 
Asp Asp Phe Ile Leu Gly Ile Leu Asn Cys Val Phe Ile Val Tyr Tyr 
465                 470                 475                 480 
Leu Leu Glu Met Leu Leu Lys Val Phe Ala Leu Gly Leu Arg Gly Tyr 
                485                 490                 495     
Leu Ser Tyr Pro Ser Asn Val Phe Asp Gly Leu Leu Thr Val Val Leu 
            500                 505                 510         
Leu Val Leu Glu Ile Ser Thr Leu Ala Val Tyr Arg Leu Pro His Pro 
        515                 520                 525             
Gly Trp Arg Pro Glu Met Val Gly Leu Leu Ser Leu Trp Asp Met Thr 
    530                 535                 540                 
Arg Met Leu Asn Met Leu Ile Val Phe Arg Phe Leu Arg Ile Ile Pro 
545                 550                 555                 560 
Ser Met Lys Leu Met Ala Val Val Ala Ser Thr Val Leu Gly Leu Val 
                565                 570                 575     
Gln Asn Met Arg Ala Phe Gly Gly Ile Leu Val Val Val Tyr Tyr Val 
            580                 585                 590         
Phe Ala Ile Ile Gly Ile Asn Leu Phe Arg Gly Val Ile Val Ala Leu 
        595                 600                 605             
Pro Gly Asn Ser Ser Leu Ala Pro Ala Asn Gly Ser Ala Pro Cys Gly 
    610                 615                 620                 
Ser Phe Glu Gln Leu Glu Tyr Trp Ala Asn Asn Phe Asp Asp Phe Ala 
625                 630                 635                 640 
Ala Ala Leu Val Thr Leu Trp Asn Leu Met Val Val Asn Asn Trp Gln 
                645                 650                 655     
Val Phe Leu Asp Ala Tyr Arg Arg Tyr Ser Gly Pro Trp Ser Lys Ile 
            660                 665                 670         
Tyr Phe Val Leu Trp Trp Leu Val Ser Ser Val Ile Trp Val Asn Leu 
        675                 680                 685             
Phe Leu Ala Leu Ile Leu Glu Asn Phe Leu His Lys Trp Asp Pro Arg 
    690                 695                 700                 
Ser His Leu Gln Pro Leu Ala Gly Thr Pro Glu Ala Thr Tyr Gln Met 
705                 710                 715                 720 
Thr Val Glu Leu Leu Phe Arg Asp Ile Leu Glu Glu Pro Gly Glu Asp 
                725                 730                 735     
Glu Leu Thr Glu Arg Leu Ser Gln His Pro His Leu Trp Leu Cys Arg 
            740                 745                 750         



