                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH AN
      IMPRINTING DEFECT

<130> 167705.014101/PCT

<140> PCT/US2018/042876
<141> 2018-07-19

<150> 62/534,532
<151> 2017-07-19

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 747
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Ile Pro Asn Pro Pro Thr Ser Lys Cys Ile Thr Tyr Trp Lys 
1               5                   10                  15      


Arg Lys Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Leu 
            20                  25                  30          


Gln Ala Asn Met Gly Ala Lys Ala Leu Tyr Val Ala Asn Phe Ala Lys 
        35                  40                  45              


Val Gln Glu Lys Thr Gln Ile Leu Asn Glu Glu Trp Lys Lys Leu Arg 
    50                  55                  60                  


Val Gln Pro Val Gln Ser Met Lys Pro Val Ser Gly His Pro Phe Leu 
65                  70                  75                  80  


Lys Lys Cys Thr Ile Glu Ser Ile Phe Pro Gly Phe Ala Ser Gln His 
                85                  90                  95      


Met Leu Met Arg Ser Leu Asn Thr Val Ala Leu Val Pro Ile Met Tyr 
            100                 105                 110         


Ser Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val 
        115                 120                 125             


Leu Cys Asn Ile Pro Tyr Met Gly Asp Glu Val Lys Glu Glu Asp Glu 
    130                 135                 140                 


Thr Phe Ile Glu Glu Leu Ile Asn Asn Tyr Asp Gly Lys Val His Gly 
145                 150                 155                 160 


Glu Glu Glu Met Ile Pro Gly Ser Val Leu Ile Ser Asp Ala Val Phe 
                165                 170                 175     


Leu Glu Leu Val Asp Ala Leu Asn Gln Tyr Ser Asp Glu Glu Glu Glu 
            180                 185                 190         


Gly His Asn Asp Thr Ser Asp Gly Lys Gln Asp Asp Ser Lys Glu Asp 
        195                 200                 205             


Leu Pro Val Thr Arg Lys Arg Lys Arg His Ala Ile Glu Gly Asn Lys 
    210                 215                 220                 


Lys Ser Ser Lys Lys Gln Phe Pro Asn Asp Met Ile Phe Ser Ala Ile 
225                 230                 235                 240 


Ala Ser Met Phe Pro Glu Asn Gly Val Pro Asp Asp Met Lys Glu Arg 
                245                 250                 255     


Tyr Arg Glu Leu Thr Glu Met Ser Asp Pro Asn Ala Leu Pro Pro Gln 
            260                 265                 270         


Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu 
        275                 280                 285             


Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys 
    290                 295                 300                 


Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn Val Tyr Lys 
305                 310                 315                 320 


Arg Lys Asn Lys Glu Ile Lys Ile Glu Pro Glu Pro Cys Gly Thr Asp 
                325                 330                 335     


Cys Phe Leu Leu Leu Glu Gly Ala Lys Glu Tyr Ala Met Leu His Asn 
            340                 345                 350         


Pro Arg Ser Lys Cys Ser Gly Arg Arg Arg Arg Arg His His Ile Val 
        355                 360                 365             


Ser Ala Ser Cys Ser Asn Ala Ser Ala Ser Ala Val Ala Glu Thr Lys 
    370                 375                 380                 


Glu Gly Asp Ser Asp Arg Asp Thr Gly Asn Asp Trp Ala Ser Ser Ser 
385                 390                 395                 400 


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Thr Lys Gln Lys Ala Ser 
                405                 410                 415     


Pro Ala Pro Pro Gln Leu Cys Val Val Glu Ala Pro Ser Glu Pro Val 
            420                 425                 430         


Glu Trp Thr Gly Ala Glu Glu Ser Leu Phe Arg Val Phe His Gly Thr 
        435                 440                 445             


Tyr Phe Asn Asn Phe Cys Ser Ile Ala Arg Leu Leu Gly Thr Lys Thr 
    450                 455                 460                 


Cys Lys Gln Val Phe Gln Phe Ala Val Lys Glu Ser Leu Ile Leu Lys 
465                 470                 475                 480 


Leu Pro Thr Asp Glu Leu Met Asn Pro Ser Gln Lys Lys Lys Arg Lys 
                485                 490                 495     


His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp 
            500                 505                 510         


Asn Ser Ser Thr Gln Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Asp 
        515                 520                 525             


Arg Pro Cys Asp Ser Thr Cys Pro Cys Ile Met Thr Gln Asn Phe Cys 
    530                 535                 540                 


Glu Lys Phe Cys Gln Cys Asn Pro Asp Cys Gln Asn Arg Phe Pro Gly 
545                 550                 555                 560 


Cys Arg Cys Lys Thr Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu 
                565                 570                 575     


Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ser 
            580                 585                 590         


Glu His Trp Asp Cys Lys Val Val Ser Cys Lys Asn Cys Ser Ile Gln 
        595                 600                 605             


Arg Gly Leu Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly 
    610                 615                 620                 


Trp Gly Thr Phe Ile Lys Glu Ser Val Gln Lys Asn Glu Phe Ile Ser 
625                 630                 635                 640 


Glu Tyr Cys Gly Glu Leu Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly 
                645                 650                 655     


Lys Val Tyr Asp Lys Tyr Met Ser Ser Phe Leu Phe Asn Leu Asn Asn 
            660                 665                 670         


Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala 
        675                 680                 685             


Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Val Met Val Asn 
    690                 695                 700                 


Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Ala Gly 
705                 710                 715                 720 


Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys 
                725                 730                 735     


Tyr Val Gly Ile Glu Arg Glu Thr Asp Val Leu 
            740                 745         


<210> 2
<211> 4697
<212> DNA
<213> Homo sapiens

<400> 2
aggaggcgcg gggcggggca cggcgcaggg gtggggccgc ggcgcgcatg cgtcctagca       60

gcgggacccg cggctcggga tggaggctgg acacctgttc tgctgttgtg tcctgccatt      120

ctcctgaaga acagaggcac actgtaaaac ccaacacttc cccttgcatt ctataagatt      180

acagcaagat ggaaatacca aatcccccta cctccaaatg tatcacttac tggaaaagaa      240

aagtgaaatc tgaatacatg cgacttcgac aacttaaacg gcttcaggca aatatgggtg      300

caaaggcttt gtatgtggca aattttgcaa aggttcaaga aaaaacccag atcctcaatg      360

aagaatggaa gaagcttcgt gtccaacctg ttcagtcaat gaagcctgtg agtggacacc      420

cttttctcaa aaagtgtacc atagagagca ttttcccggg atttgcaagc caacatatgt      480

taatgaggtc actgaacaca gttgcattgg ttcccatcat gtattcctgg tcccctctcc      540

aacagaactt tatggtagaa gatgagacgg ttttgtgcaa tattccctac atgggagatg      600

aagtgaaaga agaagatgag acttttattg aggagctgat caataactat gatgggaaag      660

tccatggtga agaagagatg atccctggat ccgttctgat tagtgatgct gtttttctgg      720

agttggtcga tgccctgaat cagtactcag atgaggagga ggaagggcac aatgacacct      780

cagatggaaa gcaggatgac agcaaagaag atctgccagt aacaagaaag agaaagcgac      840

atgctattga aggcaacaaa aagagttcca agaaacagtt cccaaatgac atgatcttca      900

gtgcaattgc ctcaatgttc cctgagaatg gtgtcccaga tgacatgaag gagaggtatc      960

gagaactaac agagatgtca gaccccaatg cacttccccc tcagtgcaca cccaacatcg     1020

atggccccaa tgccaagtct gtgcagcggg agcaatctct gcactccttc cacacacttt     1080

tttgccggcg ctgctttaaa tacgactgct tccttcaccc ttttcatgcc acccctaatg     1140

tatataaacg caagaataaa gaaatcaaga ttgaaccaga accatgtggc acagactgct     1200

tccttttgct ggaaggagca aaggagtatg ccatgctcca caacccccgc tccaagtgct     1260

ctggtcgtcg ccggagaagg caccacatag tcagtgcttc ctgctccaat gcctcagcct     1320

ctgctgtggc tgagactaaa gaaggagaca gtgacaggga cacaggcaat gactgggcct     1380

ccagttcttc agaggctaac tctcgctgtc agactcccac aaaacagaag gctagtccag     1440

ccccacctca actctgcgta gtggaagcac cctcggagcc tgtggaatgg actggggctg     1500

aagaatctct ttttcgagtc ttccatggca cctacttcaa caacttctgt tcaatagcca     1560

ggcttctggg gaccaagacg tgcaagcagg tctttcagtt tgcagtcaaa gaatcactta     1620

tcctgaagct gccaacagat gagctcatga acccctcaca gaagaagaaa agaaagcaca     1680

gattgtgggc tgcacactgc aggaagattc agctgaagaa agataactct tccacacaag     1740

tgtacaacta ccaaccctgc gaccacccag accgcccctg tgacagcacc tgcccctgca     1800

tcatgactca gaatttctgt gagaagttct gccagtgcaa cccagactgt cagaatcgtt     1860

tccctggctg tcgctgtaag acccagtgca ataccaagca atgtccttgc tatctggcag     1920

tgcgagaatg tgaccctgac ctgtgtctca cctgtggggc ctcagagcac tgggactgca     1980

aggtggtttc ctgtaaaaac tgcagcatcc agcgtggact taagaagcac ctgctgctgg     2040

ccccctctga tgtggccgga tggggcacct tcataaagga gtctgtgcag aagaacgaat     2100

tcatttctga atactgtggt gagctcatct ctcaggatga ggctgatcga cgcggaaagg     2160

tctatgacaa atacatgtcc agcttcctct tcaacctcaa taatgatttt gtagtggatg     2220

ctactcggaa aggaaacaaa attcgatttg caaatcattc agtgaatccc aactgttatg     2280

ccaaagtggt catggtgaat ggagaccatc ggattgggat ctttgccaag agggcaattc     2340

aagctggcga agagctcttc tttgattaca ggtacagcca agctgatgct ctcaagtacg     2400

tggggatcga gagggagacc gacgtccttt agccctccca ggccccacgg cagcacttat     2460

ggtagcggca ctgtcttggc tttcgtgctc acaccactgc tgctcgagtc tcctgcactg     2520

tgtctcccac actgagaaac cccccaaccc actccctctg tagtgaggcc tctgccatgt     2580

ccagagggca caaaactgtc tcaatgagag gggagacaga ggcagctagg gcttggtctc     2640

ccaggacaga gagttacaga aatgggagac tgtttctctg gcctcagaag aagcgagcac     2700

aggctggggt ggatgactta tgcgtgattt cgtgtcggct ccccaggctg tggcctcagg     2760

aatcaactta ggcagttccc aacaagcgct agcctgtaat tgtagctttc cacatcaaga     2820

gtccttatgt tattgggatg caggcaaacc tctgtggtcc taagacctgg agaggacagg     2880

ctaagtgaag tgtggtccct ggagcctaca agtggtctgg gttagaggcg agcctggcag     2940

gcagcacaga ctgaactcag aggtagacag gtcaccttac tacctcctcc ctcgtggcag     3000

ggctcaaact gaaagagtgt gggttctaag tacaggcatt caaggctggg ggaaggaaag     3060

ctacgccatc cttccttagc cagagaggga gaaccagcca gatgatagta gttaaactgc     3120

taagcttggg cccaggaggc tttgagaaag ccttctctgt gtactctgga gatagatgga     3180

gaagtgtttt cagattcctg ggaacagaca ccagtgctcc agctcctcca aagttctggc     3240

ttagcagctg caggcaagca ttatgctgct attgaagaag cattaggggt atgcctggca     3300

ggtgtgagca tcctggctcg ctggatttgt gggtgttttc aggccttcca ttccccatag     3360

aggcaaggcc caatggccag tgttgcttat cgcttcaggg taggtgggca caggcttgga     3420

ctagagagga gaaagattgg tgtaatctgc tttcctgtct gtagtgcctg ctgtttggaa     3480

agggtgagtt agaatatgtt ccaaggttgg tgaggggcta aattgcacgc gtttaggctg     3540

gcaccccgtg tgcagggcac actggcagag ggtatctgaa gtgggagaag aagcaggtag     3600

accacctgtc ccaggctgtg gtgccaccct ctctggcatt catgcagagc aaagcacttt     3660

aaccatttct tttaaaaggt ctatagattg gggtagagtt tggcctaagg tctctagggt     3720

ccctgcctaa atcccactcc tgagggaggg ggaagaagag agggtgggag attctcctcc     3780

agtcctgtct catctcctgg gagaggcaga cgagtgagtt tcacacagaa gaatttcatg     3840

tgaatggggc cagcaagagc tgccctgtgt ccatggtggg tgtgccgggc tggctgggaa     3900

caaggagcag tatgttgagt agaaagggtg tgggcgggta tagattggcc tgggagtgtt     3960

acagtaggga gcaggcttct cccttctttc tgggactcag agccccgctt cttcccactc     4020

cacttgttgt cccatgaagg aagaagtggg gttcctcctg acccagctgc ctcttacggt     4080

ttggtatggg acatgcacac acactcacat gctctcactc accacactgg agggcacaca     4140

cgtaccccgc acccagcaac tcctgacaga aagctcctcc cacccaaatg ggccaggccc     4200

cagcatgatc ctgaaatctg catccgccgt ggtttgtatt cattgtgcat atcagggata     4260

ccctcaagct ggactgtggg ttccaaatta ctcatagagg agaaaaccag agaaagatga     4320

agaggaggag ttaggtctat ttgaaatgcc aggggctcgc tgtgaggaat aggtgaaaaa     4380

aaacttttca ccagcctttg agagactaga ctgaccccac ccttccttca gtgagcagaa     4440

tcactgtggt cagtctcctg tcccagcttc agttcatgaa tactcctgtt cctccagttt     4500

cccatccttt gtccctgctg tcccccactt ttaaagatgg gtctcaaccc ctccccacca     4560

cgtcatgatg gatggggcaa ggtggtgggg actaggggag cctggtatac atgcggcttc     4620

attgccaata aatttcatgc actttaaagt cctgtggctt gtgacctctt aataaagtgt     4680

tagaatccaa aaaaaaa                                                    4697


<210> 3
<211> 746
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210> 4
<211> 2681
<212> DNA
<213> Homo sapiens

<400> 4
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt cttgttcggt      420

gaccagtgac ttggattttc caacacaagt catcccatta aagactctga atgcagttgc      480

ttcagtaccc ataatgtatt cttggtctcc cctacagcag aattttatgg tggaagatga      540

aactgtttta cataacattc cttatatggg agatgaagtt ttagatcagg atggtacttt      600

cattgaagaa ctaataaaaa attatgatgg gaaagtacac ggggatagag aatgtgggtt      660

tataaatgat gaaatttttg tggagttggt gaatgccctt ggtcaatata atgatgatga      720

cgatgatgat gatggagacg atcctgaaga aagagaagaa aagcagaaag atctggagga      780

tcaccgagat gataaagaaa gccgcccacc tcggaaattt ccttctgata aaatttttga      840

agccatttcc tcaatgtttc cagataaggg cacagcagaa gaactaaagg aaaaatataa      900

agaactcacc gaacagcagc tcccaggcgc acttcctcct gaatgtaccc ccaacataga      960

tggaccaaat gctaaatctg ttcagagaga gcaaagctta cactcctttc atacgctttt     1020

ctgtaggcga tgttttaaat atgactgctt cctacatcct tttcatgcaa cacccaacac     1080

ttataagcgg aagaacacag aaacagctct agacaacaaa ccttgtggac cacagtgtta     1140

ccagcatttg gagggagcaa aggagtttgc tgctgctctc accgctgagc ggataaagac     1200

cccaccaaaa cgtccaggag gccgcagaag aggacggctt cccaataaca gtagcaggcc     1260

cagcaccccc accattaatg tgctggaatc aaaggataca gacagtgata gggaagcagg     1320

gactgaaacg gggggagaga acaatgataa agaagaagaa gagaagaaag atgaaacttc     1380

gagctcctct gaagcaaatt ctcggtgtca aacaccaata aagatgaagc caaatattga     1440

acctcctgag aatgtggagt ggagtggtgc tgaagcctca atgtttagag tcctcattgg     1500

cacttactat gacaatttct gtgccattgc taggttaatt gggaccaaaa catgtagaca     1560

ggtgtatgag tttagagtca aagaatctag catcatagct ccagctcccg ctgaggatgt     1620

ggatactcct ccaaggaaaa agaagaggaa acaccggttg tgggctgcac actgcagaaa     1680

gatacagctg aaaaaggacg gctcctctaa ccatgtttac aactatcaac cctgtgatca     1740

tccacggcag ccttgtgaca gttcgtgccc ttgtgtgata gcacaaaatt tttgtgaaaa     1800

gttttgtcaa tgtagttcag agtgtcaaaa ccgctttccg ggatgccgct gcaaagcaca     1860

gtgcaacacc aagcagtgcc cgtgctacct ggctgtccga gagtgtgacc ctgacctctg     1920

tcttacttgt ggagccgctg accattggga cagtaaaaat gtgtcctgca agaactgcag     1980

tattcagcgg ggctccaaaa agcatctatt gctggcacca tctgacgtgg caggctgggg     2040

gatttttatc aaagatcctg tgcagaaaaa tgaattcatc tcagaatact gtggagagat     2100

tatttctcaa gatgaagctg acagaagagg gaaagtgtat gataaataca tgtgcagctt     2160

tctgttcaac ttgaacaatg attttgtggt ggatgcaacc cgcaagggta acaaaattcg     2220

ttttgcaaat cattcggtaa atccaaactg ctatgcaaaa gttatgatgg ttaacggtga     2280

tcacaggata ggtatttttg ccaagagagc catccagact ggcgaagagc tgttttttga     2340

ttacagatac agccaggctg atgccctgaa gtatgtcggc atcgaaagag aaatggaaat     2400

cccttgacat ctgctacctc ctcccccctc ctctgaaaca gctgccttag cttcaggaac     2460

ctcgagtact gtgggcaatt tagaaaaaga acatgcagtt tgaaattctg aatttgcaaa     2520

gtactgtaag aataatttat agtaatgagt ttaaaaatca actttttatt gccttctcac     2580

cagctgcaaa gtgttttgta ccagtgaatt tttgcaataa tgcagtatgg tacatttttc     2640

aactttgaat aaagaatact tgaacttgtc cttgttgaat c                         2681


<210> 5
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala 
    210                 215                 220                 


Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln 
225                 230                 235                 240 


Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val 
                245                 250                 255     


Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr 
            260                 265                 270         


Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr 
        275                 280                 285             


Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe 
    290                 295                 300                 


Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr 
305                 310                 315                 320 


Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp 
                325                 330                 335     


Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
            340                 345                 350         


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
        355                 360                 365             


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
    370                 375                 380                 


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
385                 390                 395                 400 


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
                405                 410                 415     


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
            420                 425                 430         


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn 
        435                 440                 445             


Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala 
    450                 455                 460                 


His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu 
465                 470                 475                 480 


Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu 
                485                 490                 495     


Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro 
            500                 505                 510         


Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr 
        515                 520                 525             


Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln 
    530                 535                 540                 


Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro 
545                 550                 555                 560 


Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His 
                565                 570                 575     


Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu 
            580                 585                 590         


Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro 
        595                 600                 605             


Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu 
    610                 615                 620                 


Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr 
625                 630                 635                 640 


Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly 
                645                 650                 655     


Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala 
            660                 665                 670         


Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn 
        675                 680                 685             


Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala 
    690                 695                 700                 


Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro 
705                 710                 715                 720 


Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu 
                725                 730                 735     


Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His 
            740                 745                 750         


Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys 
        755                 760                 765             


Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu 
    770                 775                 780                 


Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val 
785                 790                 795                 800 


Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala 
                805                 810                 815     


Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser 
            820                 825                 830         


Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His 
        835                 840                 845             


Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser 
    850                 855                 860                 


Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln 
865                 870                 875                 880 


Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val 
                885                 890                 895     


Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser 
            900                 905                 910         


Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr 
        915                 920                 925             


Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr 
    930                 935                 940                 


Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys 
945                 950                 955                 960 


Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala 
                965                 970                 975     


Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala 
            980                 985                 990         


Asn Asn Glu His Met Val Glu Val  Arg Thr Gln Leu Leu  Gln Pro Ala 
        995                 1000                 1005             


Asp Glu  Asn Trp Asp Pro Thr  Gly Thr Lys Lys Ile  Trp His Cys 
    1010                 1015                 1020             


Glu Ser  Asn Arg Ser His Thr  Thr Ile Ala Lys Tyr  Ala Gln Tyr 
    1025                 1030                 1035             


Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Arg Glu Glu  Asn Glu Lys 
    1040                 1045                 1050             


Arg Ser  His His Lys Asp His  Ser Asp Ser Glu Ser  Thr Ser Ser 
    1055                 1060                 1065             


Asp Asn  Ser Gly Arg Arg Arg  Lys Gly Pro Phe Lys  Thr Ile Lys 
    1070                 1075                 1080             


Phe Gly  Thr Asn Ile Asp Leu  Ser Asp Asp Lys Lys  Trp Lys Leu 
    1085                 1090                 1095             


Gln Leu  His Glu Leu Thr Lys  Leu Pro Ala Phe Val  Arg Val Val 
    1100                 1105                 1110             


Ser Ala  Gly Asn Leu Leu Ser  His Val Gly His Thr  Ile Leu Gly 
    1115                 1120                 1125             


Met Asn  Thr Val Gln Leu Tyr  Met Lys Val Pro Gly  Ser Arg Thr 
    1130                 1135                 1140             


Pro Gly  His Gln Glu Asn Asn  Asn Phe Cys Ser Val  Asn Ile Asn 
    1145                 1150                 1155             


Ile Gly  Pro Gly Asp Cys Glu  Trp Phe Val Val Pro  Glu Gly Tyr 
    1160                 1165                 1170             


Trp Gly  Val Leu Asn Asp Phe  Cys Glu Lys Asn Asn  Leu Asn Phe 
    1175                 1180                 1185             


Leu Met  Gly Ser Trp Trp Pro  Asn Leu Glu Asp Leu  Tyr Glu Ala 
    1190                 1195                 1200             


Asn Val  Pro Val Tyr Arg Phe  Ile Gln Arg Pro Gly  Asp Leu Val 
    1205                 1210                 1215             


Trp Ile  Asn Ala Gly Thr Val  His Trp Val Gln Ala  Ile Gly Trp 
    1220                 1225                 1230             


Cys Asn  Asn Ile Ala Trp Asn  Val Gly Pro Leu Thr  Ala Cys Gln 
    1235                 1240                 1245             


Tyr Lys  Leu Ala Val Glu Arg  Tyr Glu Trp Asn Lys  Leu Gln Ser 
    1250                 1255                 1260             


Val Lys  Ser Ile Val Pro Met  Val His Leu Ser Trp  Asn Met Ala 
    1265                 1270                 1275             


Arg Asn  Ile Lys Val Ser Asp  Pro Lys Leu Phe Glu  Met Ile Lys 
    1280                 1285                 1290             


Tyr Cys  Leu Leu Arg Thr Leu  Lys Gln Cys Gln Thr  Leu Arg Glu 
    1295                 1300                 1305             


Ala Leu  Ile Ala Ala Gly Lys  Glu Ile Ile Trp His  Gly Arg Thr 
    1310                 1315                 1320             


Lys Glu  Glu Pro Ala His Tyr  Cys Ser Ile Cys Glu  Val Glu Val 
    1325                 1330                 1335             


Phe Asp  Leu Leu Phe Val Thr  Asn Glu Ser Asn Ser  Arg Lys Thr 
    1340                 1345                 1350             


Tyr Ile  Val His Cys Gln Asp  Cys Ala Arg Lys Thr  Ser Gly Asn 
    1355                 1360                 1365             


Leu Glu  Asn Phe Val Val Leu  Glu Gln Tyr Lys Met  Glu Asp Leu 
    1370                 1375                 1380             


Met Gln  Val Tyr Asp Gln Phe  Thr Leu Ala Pro Pro  Leu Pro Ser 
    1385                 1390                 1395             


Ala Ser  Ser 
    1400     


<210> 6
<211> 1643
<212> PRT
<213> Homo sapiens

<400> 6
Met His Arg Ala Val Asp Pro Pro Gly Ala Arg Ala Ala Arg Glu Ala 
1               5                   10                  15      


Phe Ala Leu Gly Gly Leu Ser Cys Ala Gly Ala Trp Ser Ser Cys Pro 
            20                  25                  30          


Pro His Pro Pro Pro Arg Ser Ala Trp Leu Pro Gly Gly Arg Cys Ser 
        35                  40                  45              


Ala Ser Ile Gly Gln Pro Pro Leu Pro Ala Pro Leu Pro Pro Ser His 
    50                  55                  60                  


Gly Ser Ser Ser Gly His Pro Ser Lys Pro Tyr Tyr Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Thr Pro Arg Pro Leu His Gly Lys Leu Glu Ser Leu His Gly Cys 
                85                  90                  95      


Val Gln Ala Leu Leu Arg Glu Pro Ala Gln Pro Gly Leu Trp Glu Gln 
            100                 105                 110         


Leu Gly Gln Leu Tyr Glu Ser Glu His Asp Ser Glu Glu Ala Thr Arg 
        115                 120                 125             


Cys Tyr His Ser Ala Leu Arg Tyr Gly Gly Ser Phe Ala Glu Leu Gly 
    130                 135                 140                 


Pro Arg Ile Gly Arg Leu Gln Gln Ala Gln Leu Trp Asn Phe His Thr 
145                 150                 155                 160 


Gly Ser Cys Gln His Arg Ala Lys Val Leu Pro Pro Leu Glu Gln Val 
                165                 170                 175     


Trp Asn Leu Leu His Leu Glu His Lys Arg Asn Tyr Gly Ala Lys Arg 
            180                 185                 190         


Gly Gly Pro Pro Val Lys Arg Ala Ala Glu Pro Pro Val Val Gln Pro 
        195                 200                 205             


Val Pro Pro Ala Ala Leu Ser Gly Pro Ser Gly Glu Glu Gly Leu Ser 
    210                 215                 220                 


Pro Gly Gly Lys Arg Arg Arg Gly Cys Asn Ser Glu Gln Thr Gly Leu 
225                 230                 235                 240 


Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Leu Ala Thr Ser Pro 
            260                 265                 270         


Pro Phe Gln Leu Thr Lys Pro Gly Leu Trp Ser Thr Leu His Gly Asp 
        275                 280                 285             


Ala Trp Gly Pro Glu Arg Lys Gly Ser Ala Pro Pro Glu Arg Gln Glu 
    290                 295                 300                 


Gln Arg His Ser Leu Pro His Pro Tyr Pro Tyr Pro Ala Pro Ala Tyr 
305                 310                 315                 320 


Thr Ala His Pro Pro Gly His Arg Leu Val Pro Ala Ala Pro Pro Gly 
                325                 330                 335     


Pro Gly Pro Arg Pro Pro Gly Ala Glu Ser His Gly Cys Leu Pro Ala 
            340                 345                 350         


Thr Arg Pro Pro Gly Ser Asp Leu Arg Glu Ser Arg Val Gln Arg Ser 
        355                 360                 365             


Arg Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro 
    370                 375                 380                 


Tyr Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn 
                405                 410                 415     


Pro Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val 
            420                 425                 430         


Ser His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro 
        435                 440                 445             


Phe Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly 
    450                 455                 460                 


Pro Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro 
465                 470                 475                 480 


Pro Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu 
                485                 490                 495     


Asp Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro 
            500                 505                 510         


Arg Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro 
        515                 520                 525             


Pro Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro 
    530                 535                 540                 


Thr Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser 
545                 550                 555                 560 


His Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr 
                565                 570                 575     


Leu Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln 
            580                 585                 590         


Asn Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro 
        595                 600                 605             


Ala Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg 
    610                 615                 620                 


Pro Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val 
625                 630                 635                 640 


Gly Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val 
                645                 650                 655     


Pro Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp 
            660                 665                 670         


Phe Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe 
        675                 680                 685             


Lys Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu 
    690                 695                 700                 


Ser Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala 
705                 710                 715                 720 


Pro Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe 
                725                 730                 735     


Pro Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr 
            740                 745                 750         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu 
        755                 760                 765             


Lys Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe 
    770                 775                 780                 


Pro Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro 
785                 790                 795                 800 


Ala Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr 
                805                 810                 815     


Cys Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu 
            820                 825                 830         


Pro Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu 
        835                 840                 845             


Pro Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser 
    850                 855                 860                 


Ala Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg 
865                 870                 875                 880 


Glu Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr 
                885                 890                 895     


Gln Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu 
            900                 905                 910         


Val Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val 
        915                 920                 925             


Gly Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro 
    930                 935                 940                 


Ala Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu 
945                 950                 955                 960 


Glu Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln 
                965                 970                 975     


Lys Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp 
            980                 985                 990         


Ser Val Gly Arg Arg Pro Arg Glu  Gly Arg Ala Lys Ala  Lys Ala Lys 
        995                 1000                 1005             


Val Pro  Lys Glu Lys Ser Arg  Arg Val Leu Gly Asn  Leu Asp Leu 
    1010                 1015                 1020             


Gln Ser  Glu Glu Ile Gln Gly  Arg Glu Lys Ser Arg  Pro Asp Leu 
    1025                 1030                 1035             


Gly Gly  Ala Ser Lys Ala Lys  Pro Pro Thr Ala Pro  Ala Pro Pro 
    1040                 1045                 1050             


Ser Ala  Pro Ala Pro Ser Ala  Gln Pro Thr Pro Pro  Ser Ala Ser 
    1055                 1060                 1065             


Val Pro  Gly Lys Lys Ala Arg  Glu Glu Ala Pro Gly  Pro Pro Gly 
    1070                 1075                 1080             


Val Ser  Arg Ala Asp Met Leu  Lys Leu Arg Ser Leu  Ser Glu Gly 
    1085                 1090                 1095             


Pro Pro  Lys Glu Leu Lys Ile  Arg Leu Ile Lys Val  Glu Ser Gly 
    1100                 1105                 1110             


Asp Lys  Glu Thr Phe Ile Ala  Ser Glu Val Glu Glu  Arg Arg Leu 
    1115                 1120                 1125             


Arg Met  Ala Asp Leu Thr Ile  Ser His Cys Ala Ala  Asp Val Val 
    1130                 1135                 1140             


Arg Ala  Ser Arg Asn Ala Lys  Val Lys Gly Lys Phe  Arg Glu Ser 
    1145                 1150                 1155             


Tyr Leu  Ser Pro Ala Gln Ser  Val Lys Pro Lys Ile  Asn Thr Glu 
    1160                 1165                 1170             


Glu Lys  Leu Pro Arg Glu Lys  Leu Asn Pro Pro Thr  Pro Ser Ile 
    1175                 1180                 1185             


Tyr Leu  Glu Ser Lys Arg Asp  Ala Phe Ser Pro Val  Leu Leu Gln 
    1190                 1195                 1200             


Phe Cys  Thr Asp Pro Arg Asn  Pro Ile Thr Val Ile  Arg Gly Leu 
    1205                 1210                 1215             


Ala Gly  Ser Leu Arg Leu Asn  Leu Gly Leu Phe Ser  Thr Lys Thr 
    1220                 1225                 1230             


Leu Val  Glu Ala Ser Gly Glu  His Thr Val Glu Val  Arg Thr Gln 
    1235                 1240                 1245             


Val Gln  Gln Pro Ser Asp Glu  Asn Trp Asp Leu Thr  Gly Thr Arg 
    1250                 1255                 1260             


Gln Ile  Trp Pro Cys Glu Ser  Ser Arg Ser His Thr  Thr Ile Ala 
    1265                 1270                 1275             


Lys Tyr  Ala Gln Tyr Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Gln 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ser Glu Asp  Glu Glu Ser Glu Glu  Pro Asp Ser 
    1295                 1300                 1305             


Thr Thr  Gly Thr Pro Pro Ser  Ser Ala Pro Asp Pro  Lys Asn His 
    1310                 1315                 1320             


His Ile  Ile Lys Phe Gly Thr  Asn Ile Asp Leu Ser  Asp Ala Lys 
    1325                 1330                 1335             


Arg Trp  Lys Pro Gln Leu Gln  Glu Leu Leu Lys Leu  Pro Ala Phe 
    1340                 1345                 1350             


Met Arg  Val Thr Ser Thr Gly  Asn Met Leu Ser His  Val Gly His 
    1355                 1360                 1365             


Thr Ile  Leu Gly Met Asn Thr  Val Gln Leu Tyr Met  Lys Val Pro 
    1370                 1375                 1380             


Gly Ser  Arg Thr Pro Gly His  Gln Glu Asn Asn Asn  Phe Cys Ser 
    1385                 1390                 1395             


Val Asn  Ile Asn Ile Gly Pro  Gly Asp Cys Glu Trp  Phe Ala Val 
    1400                 1405                 1410             


His Glu  His Tyr Trp Glu Thr  Ile Ser Ala Phe Cys  Asp Arg His 
    1415                 1420                 1425             


Gly Val  Asp Tyr Leu Thr Gly  Ser Trp Trp Pro Ile  Leu Asp Asp 
    1430                 1435                 1440             


Leu Tyr  Ala Ser Asn Ile Pro  Val Tyr Arg Phe Val  Gln Arg Pro 
    1445                 1450                 1455             


Gly Asp  Leu Val Trp Ile Asn  Ala Gly Thr Val His  Trp Val Gln 
    1460                 1465                 1470             


Ala Thr  Gly Trp Cys Asn Asn  Ile Ala Trp Asn Val  Gly Pro Leu 
    1475                 1480                 1485             


Thr Ala  Tyr Gln Tyr Gln Leu  Ala Leu Glu Arg Tyr  Glu Trp Asn 
    1490                 1495                 1500             


Glu Val  Lys Asn Val Lys Ser  Ile Val Pro Met Ile  His Val Ser 
    1505                 1510                 1515             


Trp Asn  Val Ala Arg Thr Val  Lys Ile Ser Asp Pro  Asp Leu Phe 
    1520                 1525                 1530             


Lys Met  Ile Lys Phe Cys Leu  Leu Gln Ser Met Lys  His Cys Gln 
    1535                 1540                 1545             


Val Gln  Arg Glu Ser Leu Val  Arg Ala Gly Lys Lys  Ile Ala Tyr 
    1550                 1555                 1560             


Gln Gly  Arg Val Lys Asp Glu  Pro Ala Tyr Tyr Cys  Asn Glu Cys 
    1565                 1570                 1575             


Asp Val  Glu Val Phe Asn Ile  Leu Phe Val Thr Ser  Glu Asn Gly 
    1580                 1585                 1590             


Ser Arg  Asn Thr Tyr Leu Val  His Cys Glu Gly Cys  Ala Arg Arg 
    1595                 1600                 1605             


Arg Ser  Ala Gly Leu Gln Gly  Val Val Val Leu Glu  Gln Tyr Arg 
    1610                 1615                 1620             


Thr Glu  Glu Leu Ala Gln Ala  Tyr Asp Ala Phe Thr  Leu Ala Pro 
    1625                 1630                 1635             


Ala Ser  Thr Ser Arg 
    1640             


<210> 7
<211> 6731
<212> DNA
<213> Homo sapiens

<400> 7
ggcaacatgc cagccccgta gcactgccca ccccacccac tgtggtctgt tgtaccccac       60

tgctggggtg gtggttccaa tgagacaggg cacaccaaac tccatctggc tgttactgag      120

gcggagacac gggtgatgat tggctttctg gggagagagg aagtcctgtg attggccaga      180

tctctggagc ttgccgacgc ggtgtgagga cgctcccacg gaggccggaa ttggctgtga      240

aaggactgag gcagccatct gggggtagcg ggcactctta tcagagcggc tggagccgga      300

ccatcgtccc agagagctgg ggcagggggc cgtgcccaat ctccagggct cctggggcca      360

ctgctgacct ggctggatgc atcgggcagt ggaccctcca ggggcccgcg ctgcacggga      420

agcctttgcc cttgggggcc tgagctgtgc tggggcctgg agctcctgcc cgcctcatcc      480

ccctcctcgt agcgcatggc tgcctggagg cagatgctca gccagcattg ggcagccccc      540

gcttcctgct cccctacccc cttcacatgg cagtagttct gggcacccca gcaaaccata      600

ttatgctcca ggggcgccca ctccaagacc cctccatggg aagctggaat ccctgcatgg      660

ctgtgtgcag gcattgctcc gggagccagc ccagccaggg ctttgggaac agcttgggca      720

actgtacgag tcagagcacg atagtgagga ggccacacgc tgctaccaca gcgcccttcg      780

atacggagga agcttcgctg agctggggcc ccgcattggc cgactgcagc aggcccagct      840

ctggaacttt catactggct cctgccagca ccgagccaag gtcctgcccc cactggagca      900

agtgtggaac ttgctacacc ttgagcacaa acggaactat ggagccaagc ggggaggtcc      960

cccggtgaag cgagctgctg aacccccagt ggtgcagcct gtgcctcctg cagcactctc     1020

aggcccctca ggggaggagg gcctcagccc tggaggcaag cgaaggagag gctgcaactc     1080

tgaacagact ggccttcccc cagggctgcc actgcctcca ccaccattac caccaccacc     1140

accaccacca ccaccaccac caccacccct gcctggcctg gctaccagcc ccccatttca     1200

gctaaccaag ccagggctgt ggagtaccct gcatggagat gcctggggcc cagagcgcaa     1260

gggttcagca cccccagagc gccaggagca gcggcactcg ctgcctcacc catatccata     1320

cccagctcca gcgtacaccg cgcacccccc tggccaccgg ctggtcccgg ctgctccccc     1380

aggcccaggc ccccgccccc caggagcaga gagccatggc tgcctgcctg ccacccgtcc     1440

ccccggaagt gaccttagag agagcagagt tcagaggtcg cggatggact ccagcgtttc     1500

accagcagca accaccgcct gcgtgcctta cgccccttcc cggccccctg gcctccccgg     1560

caccaccacc agcagcagca gtagcagcag cagcaacact ggtctccggg gcgtggagcc     1620

gaacccaggc attcccggcg ctgaccatta ccaaactccc gcgctggagg tctctcacca     1680

tggccgcctg gggccctcgg cacacagcag tcggaaaccg ttcttggggg ctcccgctgc     1740

cactccccac ctatccctgc cacctggacc ttcctcaccc cctccacccc cctgtccccg     1800

cctcttacgc cccccaccac cccctgcctg gttgaagggt ccggcctgcc gggcagcccg     1860

agaggatgga gagatcttag aagagctctt ctttgggact gagggacccc cccgccctgc     1920

cccaccaccc ctcccccatc gcgagggctt cttggggcct ccggcctccc gcttttctgt     1980

gggcactcag gattctcaca cccctcccac tcccccaacc ccaaccacca gcagtagcaa     2040

cagcaacagt ggcagccaca gcagcagccc tgctgggcct gtgtcctttc ccccaccacc     2100

ctatctggcc agaagtatag acccccttcc ccggcctccc agcccagcac agaaccccca     2160

ggacccacct cttgtacccc tgactcttgc cctgcctcca gcccctcctt cctcctgcca     2220

ccaaaatacc tcaggaagct tcaggcgccc ggagagcccc cggcccaggg tctccttccc     2280

aaagaccccc gaggtggggc cggggccacc cccaggcccc ctgagtaaag ccccccagcc     2340

tgtgccgccc ggggttgggg agctgcctgc ccgaggccct cgactctttg attttccccc     2400

cactccgctg gaggaccagt ttgaggagcc agccgaattc aagatcctac ctgatgggct     2460

ggccaacatc atgaagatgc tggacgaatc cattcgcaag gaagaggaac agcaacaaca     2520

cgaagcaggc gtggcccccc aacccccgct gaaggagccc tttgcatctc tgcagtctcc     2580

tttccccacc gacacagccc ccaccactac tgctcctgct gtcgccgtca ccaccaccac     2640

caccaccacc accaccacca cggccaccca ggaagaggag aagaagccac caccagccct     2700

accaccacca ccgcctctag ccaagttccc tccaccctct cagccacagc caccaccacc     2760

cccacccccc agcccggcca gcctgctcaa atccttggcc tccgtgctgg agggacaaaa     2820

gtactgttat cgggggactg gagcagctgt ttccacccgg cctgggccct tgcccaccac     2880

tcagtattcc cctggccccc catcaggtgc taccgccctg ccgcccacct cagcggcccc     2940

tagcgcccag ggctccccac agccctctgc ttcctcgtca tctcagttct ctacctcagg     3000

cgggccctgg gcccgggagc gcagggcggg cgaagagcca gtcccgggcc ccatgacccc     3060

cacccaaccg cccccacccc tatctctgcc ccctgctcgc tctgagtctg aggtgctaga     3120

agagatcagc cgggcttgcg agacccttgt ggagcgggtg ggccggagtg ccactgaccc     3180

agccgaccca gtggacacag cagagccagc ggacagtggg actgagcgac tgctgccccc     3240

cgcacaggcc aaggaggagg ctggcggggt ggcggcagtg tcaggcagct gtaagcggcg     3300

acagaaggag catcagaagg agcatcggcg gcacaggcgg gcctgtaagg acagtgtggg     3360

tcgtcggccc cgtgagggca gggcaaaggc caaggccaag gtccccaaag aaaagagccg     3420

ccgggtgctg gggaacctgg acctgcagag cgaggagatc cagggtcgtg agaagtcccg     3480

gcccgatctt ggcggggcct ccaaggccaa gccacccaca gctccagccc ctccatcagc     3540

tcctgcacct tctgcccagc ccacaccccc gtcagcctct gtccctggaa agaaggctcg     3600

ggaggaagcc ccagggccac cgggtgtcag ccgggccgac atgctgaagc tgcgctcact     3660

tagtgagggg ccccccaagg agctgaagat ccggctcatc aaggtagaga gtggtgacaa     3720

ggagaccttt atcgcctctg aggtggaaga gcggcggctg cgcatggcag acctcaccat     3780

cagccactgt gctgctgacg tcgtgcgcgc cagcaggaat gccaaggtga aagggaagtt     3840

tcgagagtcc tacctttccc ctgcccagtc tgtgaaaccg aagatcaaca ctgaggagaa     3900

gctgccccgg gaaaaactca acccccctac acccagcatc tatctggaga gcaaacggga     3960

tgccttctca cctgtcctgc tgcagttctg tacagaccct cgaaatccca tcacagtgat     4020

ccggggcctg gcgggctccc tgcggctcaa cttgggcctc ttctccacca agaccctggt     4080

ggaagcgagt ggcgaacaca ccgtggaagt tcgcacccag gtgcagcagc cctcagatga     4140

gaactgggat ctgacaggca ctcggcagat ctggccttgt gagagctccc gttcccacac     4200

caccattgcc aagtacgcac agtaccaggc ctcatccttc caggagtctc tgcaggagga     4260

gaaggagagt gaggatgagg agtcagagga gccagacagc accactggaa cccctcctag     4320

cagcgcacca gacccgaaga accatcacat catcaagttt ggcaccaaca tcgacttgtc     4380

tgatgctaag cggtggaagc cccagctgca ggagctgctg aagctgcccg ccttcatgcg     4440

ggtaacatcc acgggcaaca tgctgagcca cgtgggccac accatcctgg gcatgaacac     4500

ggtgcagctg tacatgaagg tgcccggcag ccgaacgcca ggccaccagg agaataacaa     4560

cttctgctcc gtcaacatca acattggccc aggcgactgc gagtggttcg cggtgcacga     4620

gcactactgg gagaccatca gcgctttctg tgatcggcac ggcgtggact acttgacggg     4680

ttcctggtgg ccaatcctgg atgatctcta tgcatccaat attcctgtgt accgcttcgt     4740

gcagcgaccc ggagacctcg tgtggattaa tgcggggact gtgcactggg tgcaggccac     4800

cggctggtgc aacaacattg cctggaacgt ggggcccctc accgcctatc agtaccagct     4860

ggccctggaa cgatacgagt ggaatgaggt gaagaacgtc aaatccatcg tgcccatgat     4920

tcacgtgtca tggaacgtgg ctcgcacggt caaaatcagc gaccccgact tgttcaagat     4980

gatcaagttc tgcctgctgc agtccatgaa gcactgccag gtgcaacgcg agagcctggt     5040

gcgggcaggg aagaaaatcg cttaccaggg ccgtgtcaag gacgagccag cctactactg     5100

caacgagtgc gatgtggagg tgtttaacat cctgttcgtg acaagtgaga atggcagccg     5160

caacacgtac ctggtacact gcgagggctg tgcccggcgc cgcagcgcag gcctgcaggg     5220

cgtggtggtg ctggagcagt accgcactga ggagctggct caggcctacg acgccttcac     5280

gctggtgagg gcccggcggg cgcgcgggca gcggaggagg gcactggggc aggctgcagg     5340

gacgggcttc gggagcccgg ccgcgccttt ccctgagccc ccgccggctt tctcccccca     5400

ggccccagcc agcacgtcgc gatgaggccg gacgccccgc ccgcctgcct gcccgcgcaa     5460

ggcgccgcgg ggccaccagc acatgcctgg gctggaccta ggtcccgcct gtggccgaga     5520

agggggtcgg gcccagccct tccaccccat tggcagctcc cctcacttaa tttattaaga     5580

aaaacttttt tttttttttt agcaaatatg aggaaaaaag gaaaaaaaat gggagacggg     5640

ggagggggct ggcagcccct cgcccaccag cgcctcccct caccgacttt ggccttttta     5700

gcaacagaca caaggaccag gctccggcgg cggcgggggt cacatacggg ttccctcacc     5760

ctgccagccg cccgcccgcc cggcgcagat gcacgcggct cgtgtatgta catagacgtt     5820

acggcagccg aggtttttaa tgagattctt tctatgggct ttacccctcc cccggaacct     5880

ccttttttac ttccaatgct agctgtgacc cctgtacatg tctctttatt cacttggtta     5940

tgatttgtat tttttgttct tttcttgttt ttttgttttt aatttataac agtcccactc     6000

acctctattt attcattttt gggaaaaccc gacctcccac acccccaagc catcctgccc     6060

gcccctccag ggaccgcccg tcgccgggct ctccccgcgc cccagtgtgt gtccgggccc     6120

ggcccgaccg tctccacccg tccgcccgcg gctccagccg ggttctcatg gtgctcaaac     6180

ccgctcccct cccctacgtc ctgcactttc tcggaccagt ccccccactc ccgacccgac     6240

cccagcccca cctgagggtg agcaactcct gtactgtagg ggaagaagtg ggaactgaaa     6300

tggtattttg taaaaaaaat aaataaaata aaaaaattaa aggttttaaa gaaagaacta     6360

tgaggaaaag gaaccccgtc cttcccagcc ccggccaact ttaaaaaaca cagaccttca     6420

cccccacccc cttttctttt taagtgtgaa acaacccagg gccagggcct cactggggca     6480

gggacacccc ggggtgagtt tctctggggc tttattttcg ttttgttggt tgttttttct     6540

ccacgctggg gctgcggagg ggtggggggt ttacagtccc gcaccctcgc actgcactgt     6600

ctctctgccc caggggcaga ggggtcttcc caaccctacc cctattttcg gtgatttttg     6660

tgtgagaata ttaatattaa aaataaacgg agaaaaaaaa aaaaaaaaaa aaaaaaaaaa     6720

aaaaaaaaaa a                                                          6731


<210> 8
<211> 1347
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Ser Cys Ala Val Ser Leu Thr Thr Ala Ala Val Ala Phe Gly 
1               5                   10                  15      


Asp Glu Ala Lys Lys Met Ala Glu Gly Lys Ala Ser Arg Glu Ser Glu 
            20                  25                  30          


Glu Glu Ser Val Ser Leu Thr Val Glu Glu Arg Glu Ala Leu Gly Gly 
        35                  40                  45              


Met Asp Ser Arg Leu Phe Gly Phe Val Arg Leu His Glu Asp Gly Ala 
    50                  55                  60                  


Arg Thr Lys Thr Leu Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu 
65                  70                  75                  80  


Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu 
                85                  90                  95      


Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Ser Lys Ala Leu Ser Ala 
            100                 105                 110         


Tyr Gln Arg Tyr Tyr Ser Leu Gln Ala Asp Tyr Trp Lys Asn Ala Ala 
        115                 120                 125             


Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe Tyr Tyr Asn Ala Phe His 
    130                 135                 140                 


Trp Ala Ile Lys Ala Phe Gln Asp Val Leu Tyr Val Asp Pro Ser Phe 
145                 150                 155                 160 


Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met Phe Lys Val 
                165                 170                 175     


Asn Thr Asp Tyr Lys Ser Ser Leu Lys His Phe Gln Leu Ala Leu Ile 
            180                 185                 190         


Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile 
        195                 200                 205             


Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala 
    210                 215                 220                 


Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Pro Ala Gln Val Lys Ala 
225                 230                 235                 240 


Thr Val Leu Gln Gln Leu Gly Trp Met His His Asn Met Asp Leu Val 
                245                 250                 255     


Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys 
            260                 265                 270         


Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly 
        275                 280                 285             


Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr 
    290                 295                 300                 


Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser 
305                 310                 315                 320 


Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln 
                325                 330                 335     


Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala Ala Ala Trp 
            340                 345                 350         


Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala 
        355                 360                 365             


Ile Lys Cys Tyr Leu Asn Ala Ala Arg Ser Lys Arg Cys Ser Asn Thr 
    370                 375                 380                 


Ser Thr Leu Ala Ala Arg Ile Lys Phe Leu Gln Asn Gly Ser Asp Asn 
385                 390                 395                 400 


Trp Asn Gly Gly Gln Ser Leu Ser His His Pro Val Gln Gln Val Tyr 
                405                 410                 415     


Ser Leu Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg 
            420                 425                 430         


Ala Asn Arg Asp Asn Leu Asn Pro Ala Gln Lys His Gln Leu Glu Gln 
        435                 440                 445             


Leu Glu Ser Gln Phe Val Leu Met Gln Gln Met Arg His Lys Glu Val 
    450                 455                 460                 


Ala Gln Val Arg Thr Thr Gly Ile His Asn Gly Ala Ile Thr Asp Ser 
465                 470                 475                 480 


Ser Leu Pro Thr Asn Ser Val Ser Asn Arg Gln Pro His Gly Ala Leu 
                485                 490                 495     


Thr Arg Val Ser Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Val 
            500                 505                 510         


Glu Lys Leu Leu Ser Ser Gly Ala Phe Ser Ala Gly Cys Ile Pro Cys 
        515                 520                 525             


Gly Thr Ser Lys Ile Leu Gly Ser Thr Asp Thr Ile Leu Leu Gly Ser 
    530                 535                 540                 


Asn Cys Ile Ala Gly Ser Glu Ser Asn Gly Asn Val Pro Tyr Leu Gln 
545                 550                 555                 560 


Gln Asn Thr His Thr Leu Pro His Asn His Thr Asp Leu Asn Ser Ser 
                565                 570                 575     


Thr Glu Glu Pro Trp Arg Lys Gln Leu Ser Asn Ser Ala Gln Gly Leu 
            580                 585                 590         


His Lys Ser Gln Ser Ser Cys Leu Ser Gly Pro Asn Glu Glu Gln Pro 
        595                 600                 605             


Leu Phe Ser Thr Gly Ser Ala Gln Tyr His Gln Ala Thr Ser Thr Gly 
    610                 615                 620                 


Ile Lys Lys Ala Asn Glu His Leu Thr Leu Pro Ser Asn Ser Val Pro 
625                 630                 635                 640 


Gln Gly Asp Ala Asp Ser His Leu Ser Cys His Thr Ala Thr Ser Gly 
                645                 650                 655     


Gly Gln Gln Gly Ile Met Phe Thr Lys Glu Ser Lys Pro Ser Lys Asn 
            660                 665                 670         


Arg Ser Leu Val Pro Glu Thr Ser Arg His Thr Gly Asp Thr Ser Asn 
        675                 680                 685             


Gly Cys Ala Asp Val Lys Gly Leu Ser Asn His Val His Gln Leu Ile 
    690                 695                 700                 


Ala Asp Ala Val Ser Ser Pro Asn His Gly Asp Ser Pro Asn Leu Leu 
705                 710                 715                 720 


Ile Ala Asp Asn Pro Gln Leu Ser Ala Leu Leu Ile Gly Lys Ala Asn 
                725                 730                 735     


Gly Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile His Pro 
            740                 745                 750         


Ala Val His Thr Lys Thr Asp His Ser Val Ala Ser Ser Pro Ser Ser 
        755                 760                 765             


Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln Arg Ser 
    770                 775                 780                 


Ile Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu His Thr 
785                 790                 795                 800 


Val Asn Gly Glu Gly Leu Gly Lys Ser Gln Ser Ser Thr Lys Val Asp 
                805                 810                 815     


Leu Pro Leu Ala Ser His Arg Ser Thr Ser Gln Ile Leu Pro Ser Met 
            820                 825                 830         


Ser Val Ser Ile Cys Pro Ser Ser Thr Glu Val Leu Lys Ala Cys Arg 
        835                 840                 845             


Asn Pro Gly Lys Asn Gly Leu Ser Asn Ser Cys Ile Leu Leu Asp Lys 
    850                 855                 860                 


Cys Pro Pro Pro Arg Pro Pro Thr Ser Pro Tyr Pro Pro Leu Pro Lys 
865                 870                 875                 880 


Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn Lys Arg 
                885                 890                 895     


Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro Lys Asn 
            900                 905                 910         


Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys Leu Asp Leu 
        915                 920                 925             


Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn Glu His Met 
    930                 935                 940                 


Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu Asn Trp Asp 
945                 950                 955                 960 


Pro Thr Gly Thr Lys Lys Ile Trp Arg Cys Glu Ser Asn Arg Ser His 
                965                 970                 975     


Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser Phe Gln Glu 
            980                 985                 990         


Ser Leu Arg Glu Glu Asn Glu Lys  Arg Thr Gln His Lys  Asp His Ser 
        995                 1000                 1005             


Asp Asn  Glu Ser Thr Ser Ser  Glu Asn Ser Gly Arg  Arg Arg Lys 
    1010                 1015                 1020             


Gly Pro  Phe Lys Thr Ile Lys  Phe Gly Thr Asn Ile  Asp Leu Ser 
    1025                 1030                 1035             


Asp Asn  Lys Lys Trp Lys Leu  Gln Leu His Glu Leu  Thr Lys Leu 
    1040                 1045                 1050             


Pro Ala  Phe Ala Arg Val Val  Ser Ala Gly Asn Leu  Leu Thr His 
    1055                 1060                 1065             


Val Gly  His Thr Ile Leu Gly  Met Asn Thr Val Gln  Leu Tyr Met 
    1070                 1075                 1080             


Lys Val  Pro Gly Ser Arg Thr  Pro Gly His Gln Glu  Asn Asn Asn 
    1085                 1090                 1095             


Phe Cys  Ser Val Asn Ile Asn  Ile Gly Pro Gly Asp  Cys Glu Trp 
    1100                 1105                 1110             


Phe Val  Val Pro Glu Asp Tyr  Trp Gly Val Leu Asn  Asp Phe Cys 
    1115                 1120                 1125             


Glu Lys  Asn Asn Leu Asn Phe  Leu Met Ser Ser Trp  Trp Pro Asn 
    1130                 1135                 1140             


Leu Glu  Asp Leu Tyr Glu Ala  Asn Val Pro Val Tyr  Arg Phe Ile 
    1145                 1150                 1155             


Gln Arg  Pro Gly Asp Leu Val  Trp Ile Asn Ala Gly  Thr Val His 
    1160                 1165                 1170             


Trp Val  Gln Ala Val Gly Trp  Cys Asn Asn Ile Ala  Trp Asn Val 
    1175                 1180                 1185             


Gly Pro  Leu Thr Ala Cys Gln  Tyr Lys Leu Ala Val  Glu Arg Tyr 
    1190                 1195                 1200             


Glu Trp  Asn Lys Leu Lys Ser  Val Lys Ser Pro Val  Pro Met Val 
    1205                 1210                 1215             


His Leu  Ser Trp Asn Met Ala  Arg Asn Ile Lys Val  Ser Asp Pro 
    1220                 1225                 1230             


Lys Leu  Phe Glu Met Ile Lys  Tyr Cys Leu Leu Lys  Ile Leu Lys 
    1235                 1240                 1245             


Gln Tyr  Gln Thr Leu Arg Glu  Ala Leu Val Ala Ala  Gly Lys Glu 
    1250                 1255                 1260             


Val Ile  Trp His Gly Arg Thr  Asn Asp Glu Pro Ala  His Tyr Cys 
    1265                 1270                 1275             


Ser Ile  Cys Glu Val Glu Val  Phe Asn Leu Leu Phe  Val Thr Asn 
    1280                 1285                 1290             


Glu Ser  Asn Thr Gln Lys Thr  Tyr Ile Val His Cys  His Asp Cys 
    1295                 1300                 1305             


Ala Arg  Lys Thr Ser Lys Ser  Leu Glu Asn Phe Val  Val Leu Glu 
    1310                 1315                 1320             


Gln Tyr  Lys Met Glu Asp Leu  Ile Gln Val Tyr Asp  Gln Phe Thr 
    1325                 1330                 1335             


Leu Ala  Leu Ser Leu Ser Ser  Ser Ser 
    1340                 1345         


<210> 9
<211> 6817
<212> DNA
<213> Homo sapiens

<400> 9
gctcatcgtt tgttgtttag ataatatcat gaactgataa atgcagttgc cacgttgatt       60

ccctagggcc tggcttaccg actgaggtca taagatatta tgccttctct ttagacttgg      120

tcagtggaga ggaaatgggc aaagaaccag cctatggagg tgacaaggcc ttagggccaa      180

aagtcttgag ggtgaaggtt tagggcctgc gcagcttccc tgccatgccc cgcaaggtct      240

cgcattcgca aggcttgtga cagtgggagc ctcattacgg actctcctaa agtccatggt      300

gtcctctttt cgcatttgcg ccccgtgggt gatgcccgat gccgcccttc ccatcgctct      360

cttccccttc aagcgtatcg caactgcaaa aacacccagc acagacactc cattttctat      420

cttaatgcat ttaactagca caacctacag gttgttccat cccagagact acccttttct      480

ccatagacgt gaccatcaac caaccagcgg tcagaatcag tcagcctctg tcatgttcct      540

aggtccttgg cgaactggct gggcggggtc ccagcagcct aggagtacag tggagcaatg      600

cctgacgtaa gtcaacaaag atcacgtgag acgaatcagt cgcctagatt ggctacaact      660

aagtggttgg gagcggggag gtcgcggcgg ctgcgtgggg ttcgcccgtg acacaattac      720

aactttgtgc tggtgctggc aaagtttgtg attttaagaa attctgctgt gctctccagc      780

actgcgagct tctgccttcc ctgtagtttc ccagatgtga tccaggtagc cgagttccgc      840

tgcccgtgct tcggtagctt aagtctttgc ctcagctttt ttccttgcag ccgctgagga      900

ggcgataaaa ttggcgtcac agtctcaagc agcgattgaa ggcgtctttt caactactcg      960

attaaggttg ggtatcgtcg tgggacttgg aaatttgttg tttccatgaa atcctgcgca     1020

gtgtcgctca ctaccgccgc tgttgccttc ggtgatgagg caaagaaaat ggcggaagga     1080

aaagcgagcc gcgagagtga agaggagtct gttagcctga cagtcgagga aagggaggcg     1140

cttggtggca tggacagccg tctcttcggg ttcgtgaggc ttcatgaaga tggcgccaga     1200

acgaagaccc tactaggcaa ggctgttcgc tgctacgaat ctttaatctt aaaagctgaa     1260

ggaaaagtgg agtctgactt cttttgccaa ttaggtcact tcaacctctt gttggaagat     1320

tattcaaaag cattatctgc atatcagaga tattacagtt tacaggctga ctactggaag     1380

aatgctgcgt ttttatatgg ccttggtttg gtctacttct actacaatgc atttcattgg     1440

gcaattaaag catttcaaga tgtcctttat gttgacccca gcttttgtcg agccaaggaa     1500

attcatttac gacttgggct catgttcaaa gtgaacacag actacaagtc tagtttaaag     1560

cattttcagt tagccttgat tgactgtaat ccatgtactt tgtccaatgc tgaaattcaa     1620

tttcatattg cccatttgta tgaaacccag aggaagtatc attctgcaaa ggaggcatat     1680

gaacaacttt tgcagacaga aaaccttcct gcacaagtaa aagcaactgt attgcaacag     1740

ttaggttgga tgcatcataa tatggatcta gtaggagaca aagccacaaa ggaaagctat     1800

gctattcagt atctccaaaa gtctttggag gcagatccta attctggcca atcgtggtat     1860

tttcttggaa ggtgttattc aagtattggg aaagttcagg atgcctttat atcttacagg     1920

caatctattg ataaatcaga agcaagtgca gatacatggt gttcaatagg tgtgttgtat     1980

cagcagcaaa atcagcctat ggatgcttta caggcatata tttgtgctgt acaattggac     2040

catgggcatg ccgcagcctg gatggaccta ggtactctct atgaatcctg caatcaacct     2100

caagatgcca ttaaatgcta cctaaatgca gctagaagca aacgttgtag taatacctct     2160

acgcttgctg caagaattaa atttctacag gctcagttgt gtaaccttcc acaaagtagt     2220

ctacagaata aaactaaatt acttcctagt attgaggagg catggagcct accaatcccc     2280

gcagagctta cctccaggca gggtgccatg aacacagcac agcaggctta tagagctcat     2340

gatccaaata ctgaacatgt attaaaccac agtcaaacac caattttaca gcaatccttg     2400

tcactacaca tgattacttc tagccaagta gaaggcctgt ccagtcctgc caagaagaaa     2460

agaacatcta gtccaacaaa gaatggttct gataactgga atggtggcca gagtctttca     2520

catcatccag tacagcaagt ttattcgttg tgtttgacac cacagaaatt acagcacttg     2580

gaacaactgc gagcaaatag agataattta aatccagcac agaagcatca gctggaacag     2640

ttagaaagtc agtttgtctt aatgcagcaa atgagacaca aagaagttgc tcaggtacga     2700

actactggaa ttcataacgg ggccataact gattcatcac tgcctacaaa ctctgtctct     2760

aatcgacaac cacatggtgc tctgaccaga gtatctagcg tctctcagcc tggagttcgc     2820

cctgcttgtg ttgaaaaact tttgtccagt ggagcttttt ctgcaggctg tattccttgt     2880

ggcacatcaa aaattctagg aagtacagac actatcttgc taggcagtaa ttgtatagca     2940

ggaagtgaaa gtaatggaaa tgtgccttac ctgcagcaaa atacacacac tctacctcat     3000

aatcatacag acctgaacag cagcacagaa gagccatgga gaaaacagct atctaactcc     3060

gctcaggggc ttcataaaag tcagagttca tgtttgtcag gacctaatga agaacaacct     3120

ctgttttcca ctgggtcagc ccagtatcac caggcaacta gcactggtat taagaaggcg     3180

aatgaacatc tcactctgcc tagtaattca gtaccacagg gggatgctga cagtcacctc     3240

tcctgtcata ctgctacctc aggtggacaa caaggcatta tgtttaccaa agagagcaag     3300

ccttcaaaaa atagatcctt ggtgcctgaa acaagcaggc atactggaga cacatctaat     3360

ggctgtgctg atgtcaaggg actttctaat catgttcatc agttgatagc agatgctgtt     3420

tccagtccta accatggaga ttcaccaaat ttattaattg cagacaatcc tcagctctct     3480

gctttgttga ttggaaaagc caatggcaat gtgggtactg gaacctgtga caaagtgaat     3540

aatattcacc cagctgttca tacaaagact gatcattctg ttgcctcttc accctcttca     3600

gccatttcca cagcaacacc ttctcctaaa tccactgagc agagaagcat aaacagtgtt     3660

accagcctta acagtcctca cagtggatta cacacagtca atggagaggg gctggggaag     3720

tcacagagct ctacaaaagt agacctgcct ttagctagcc acagatctac ttctcagatc     3780

ttaccatcaa tgtcagtgtc tatatgcccc agttcaacag aagttctgaa agcatgcagg     3840

aatccaggta aaaatggctt gtctaatagc tgcattttgt tagataaatg tccacctcca     3900

agaccaccaa cttcaccata cccacccttg ccaaaggaca agttgaatcc acccacacct     3960

agtatttact tggaaaataa acgtgatgct ttctttcctc cattacatca attttgtaca     4020

aatccaaaaa accctgttac agtaatacgt ggccttgctg gagctcttaa attagatctt     4080

ggacttttct ctaccaaaac tttggtagaa gctaacaatg aacatatggt agaagtgagg     4140

acacagttgc tgcaaccagc agatgaaaac tgggatccca ctggaacaaa gaaaatctgg     4200

cgttgtgaaa gcaatagatc tcatactaca attgccaaat acgcacaata ccaggcttcc     4260

tccttccagg aatcattgag agaagaaaat gagaaaagaa cacaacacaa agatcattca     4320

gataacgaat ccacatcttc agagaattct ggaaggagaa ggaaaggacc ttttaaaacc     4380

ataaaatttg ggaccaacat tgacctctct gataacaaaa agtggaagtt gcagttacat     4440

gaactgacta aacttcctgc ttttgcgcgt gtggtgtcag caggaaatct tctaacccat     4500

gttgggcata ccattctggg catgaataca gtacaactgt atatgaaagt tccagggagt     4560

cggacaccag gtcaccaaga aaataacaac ttctgctctg ttaacataaa tattggtcca     4620

ggagattgtg aatggtttgt tgtacctgaa gattattggg gtgttctgaa tgacttctgt     4680

gaaaaaaata atttgaattt tttaatgagt tcttggtggc ccaaccttga agatctttat     4740

gaagcaaatg tccctgtgta tagatttatt cagcgacctg gagatttggt ctggataaat     4800

gcaggcactg tgcattgggt tcaagctgtt ggctggtgca ataacattgc ctggaatgtt     4860

ggtccactta cagcctgcca gtataaattg gcagtggaac ggtatgaatg gaacaaattg     4920

aaaagtgtga agtcaccagt acccatggtg catctttcct ggaatatggc acgaaatatc     4980

aaagtctcag atccaaagct ttttgaaatg attaagtatt gtcttttgaa aattctgaag     5040

caatatcaga cattgagaga agctcttgtt gcagcaggaa aagaggttat atggcatggg     5100

cggacaaatg atgaaccagc tcattactgt agcatttgtg aggtggaggt ttttaatctg     5160

ctttttgtca ctaatgaaag caatactcaa aaaacctaca tagtacattg ccatgattgt     5220

gcacgaaaaa caagcaaaag tttggaaaat tttgtggtgc tcgaacagta caaaatggag     5280

gacctaatcc aagtttatga tcaatttaca ctagctcttt cattatcatc ctcatcttga     5340

tatagttcca tgaatattaa atgagattat ttctgctctt caggaaattt ctgcaccact     5400

ggttttgtag ctgtttcata aaactgttga ctaaaagcta tgtctatgca accttccaag     5460

aatagtatgt caagcaactg gacacagtgc tgcctctgct tcaggactta acatgctgat     5520

ccagctgtac ttcagaaaaa taatattaat catatgtttt gtgtacgtat gacaaactgt     5580

caaagtgaca cagaatactg atttgaagat agcctttttt atgtttctct atttctgggc     5640

tgatgaatta atattcattt gtattttaac cctgcagaat tttccttagt taaaaacact     5700

ttcctagctg gtcatttctt cataagatag caaatttaaa tctctcctcg atcagctttt     5760

aaaaaatgtg tactattatc tgaggaagtt ttttactgct ttatgttttt gtgtgttttg     5820

aggccatgat gattacattt gtggttccaa aataattttt ttaaatatta atagcccata     5880

tacaaagata atggattgca catagacaaa gaaataaact tcagatttgt gatttttgtt     5940

tctaaacttg atacagattt acactattta taaatacgta tttattgcct gaaaatattt     6000

gtgaatggaa tgttgttttt ttccagacgt aactgccatt aaatactaag gagttctgta     6060

gttttaaaca ctactcctat tacattttat atgtgtagat aaaactgctt agtattatac     6120

agaaattttt attaaaattg ttaaatgttt aaagggtttc ccaatgtttg agtttaaaaa     6180

agactttctg aaaaaatcca ctttttgttc attttcaaac ctaatgatta tatgtatttt     6240

atatgtgtgt gtatgtgtac acacatgtat aatatataca gaaacctcga tatataattg     6300

tatagatttt aaaagtttta ttttttacat ctatggtagt ttttgaggtg cctattataa     6360

agtattacgg aagtttgctg tttttaaagt aaatgtcttt tagtgtgatt tattaagttg     6420

tagtcaccat agtgatagcc cataaataat tgctggaaaa ttgtatttta taacagtaga     6480

aaacatatag tcagtgaagt aaatatttta aaggaaacat tatatagatt tgataaatgt     6540

tgtttataat taagagtttc ttatggaaaa gagattcaga atgataacct cttttagaga     6600

acaaataagt gacttatttt tttaaagcta gatgactttg aaatgctata ctgtcctgct     6660

tgtacaacat ggtttggggt gaaggggagg aaagtattaa aaaatctata tcgctagtaa     6720

attgtaataa gttctattaa aacttgtatt tcatatgaaa aatttgctaa tttaatatta     6780

actcatttga taataatact tgtcttttct acctctc                              6817


<210> 10
<211> 724
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Gly Gly Glu Val Val Cys Ser Gly Trp Leu Arg Lys Ser Pro 
1               5                   10                  15      


Pro Glu Lys Lys Leu Lys Arg Tyr Ala Trp Lys Arg Arg Trp Phe Val 
            20                  25                  30          


Leu Arg Ser Gly Arg Leu Thr Gly Asp Pro Asp Val Leu Glu Tyr Tyr 
        35                  40                  45              


Lys Asn Asp His Ala Lys Lys Pro Ile Arg Ile Ile Asp Leu Asn Leu 
    50                  55                  60                  


Cys Gln Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Phe Glu 
65                  70                  75                  80  


Asn Ser Tyr Ile Phe Asp Ile Asn Thr Ile Asp Arg Ile Phe Tyr Leu 
                85                  90                  95      


Val Ala Asp Ser Glu Glu Glu Met Asn Lys Trp Val Arg Cys Ile Cys 
            100                 105                 110         


Asp Ile Cys Gly Phe Asn Pro Thr Glu Glu Asp Pro Val Lys Pro Pro 
        115                 120                 125             


Gly Ser Ser Leu Gln Ala Pro Ala Asp Leu Pro Leu Ala Ile Asn Thr 
    130                 135                 140                 


Ala Pro Pro Ser Thr Gln Ala Asp Ser Ser Ser Ala Thr Leu Pro Pro 
145                 150                 155                 160 


Pro Tyr Gln Leu Ile Asn Val Pro Pro His Leu Glu Thr Leu Gly Ile 
                165                 170                 175     


Gln Glu Asp Pro Gln Asp Tyr Leu Leu Leu Ile Asn Cys Gln Ser Lys 
            180                 185                 190         


Lys Pro Glu Pro Thr Arg Thr His Ala Asp Ser Ala Lys Ser Thr Ser 
        195                 200                 205             


Ser Glu Thr Asp Cys Asn Asp Asn Val Pro Ser His Lys Asn Pro Ala 
    210                 215                 220                 


Ser Ser Gln Ser Lys His Gly Met Asn Gly Phe Phe Gln Gln Gln Met 
225                 230                 235                 240 


Ile Tyr Asp Ser Pro Pro Ser Arg Ala Pro Ser Ala Ser Val Asp Ser 
                245                 250                 255     


Ser Leu Tyr Asn Leu Pro Arg Ser Tyr Ser His Asp Val Leu Pro Lys 
            260                 265                 270         


Val Ser Pro Ser Ser Thr Glu Ala Asp Gly Glu Leu Tyr Val Phe Asn 
        275                 280                 285             


Thr Pro Ser Gly Thr Ser Ser Val Glu Thr Gln Met Arg His Val Ser 
    290                 295                 300                 


Ile Ser Tyr Asp Ile Pro Pro Thr Pro Gly Asn Thr Tyr Gln Ile Pro 
305                 310                 315                 320 


Arg Thr Phe Pro Glu Gly Thr Leu Gly Gln Thr Ser Lys Leu Asp Thr 
                325                 330                 335     


Ile Pro Asp Ile Pro Pro Pro Arg Pro Pro Lys Pro His Pro Ala His 
            340                 345                 350         


Asp Arg Ser Pro Val Glu Thr Cys Ser Ile Pro Arg Thr Ala Ser Asp 
        355                 360                 365             


Thr Asp Ser Ser Tyr Cys Ile Pro Thr Ala Gly Met Ser Pro Ser Arg 
    370                 375                 380                 


Ser Asn Thr Ile Ser Thr Val Asp Leu Asn Lys Leu Arg Lys Asp Ala 
385                 390                 395                 400 


Ser Ser Gln Asp Cys Tyr Asp Ile Pro Arg Ala Phe Pro Ser Asp Arg 
                405                 410                 415     


Ser Ser Ser Leu Glu Gly Phe His Asn His Phe Lys Val Lys Asn Val 
            420                 425                 430         


Leu Thr Val Gly Ser Val Ser Ser Glu Glu Leu Asp Glu Asn Tyr Val 
        435                 440                 445             


Pro Met Asn Pro Asn Ser Pro Pro Arg Gln His Ser Ser Ser Phe Thr 
    450                 455                 460                 


Glu Pro Ile Gln Glu Ala Asn Tyr Val Pro Met Thr Pro Gly Thr Phe 
465                 470                 475                 480 


Asp Phe Ser Ser Phe Gly Met Gln Val Pro Pro Pro Ala His Met Gly 
                485                 490                 495     


Phe Arg Ser Ser Pro Lys Thr Pro Pro Arg Arg Pro Val Pro Val Ala 
            500                 505                 510         


Asp Cys Glu Pro Pro Pro Val Asp Arg Asn Leu Lys Pro Asp Arg Lys 
        515                 520                 525             


Gly Gln Ser Pro Lys Ile Leu Arg Leu Lys Pro His Gly Leu Glu Arg 
    530                 535                 540                 


Thr Asp Ser Gln Thr Ile Gly Asp Phe Ala Thr Arg Arg Lys Val Lys 
545                 550                 555                 560 


Pro Ala Pro Leu Glu Ile Lys Pro Leu Pro Glu Trp Glu Glu Leu Gln 
                565                 570                 575     


Ala Pro Val Arg Ser Pro Ile Thr Arg Ser Phe Ala Arg Asp Ser Ser 
            580                 585                 590         


Arg Phe Pro Met Ser Pro Arg Pro Asp Ser Val His Ser Thr Thr Ser 
        595                 600                 605             


Ser Ser Asp Ser His Asp Ser Glu Glu Asn Tyr Val Pro Met Asn Pro 
    610                 615                 620                 


Asn Leu Ser Ser Glu Asp Pro Asn Leu Phe Gly Ser Asn Ser Leu Asp 
625                 630                 635                 640 


Gly Gly Ser Ser Pro Met Ile Lys Pro Lys Gly Asp Lys Gln Val Glu 
                645                 650                 655     


Tyr Leu Asp Leu Asp Leu Asp Ser Gly Lys Ser Thr Pro Pro Arg Lys 
            660                 665                 670         


Gln Lys Ser Ser Gly Ser Gly Ser Ser Val Ala Asp Glu Arg Val Asp 
        675                 680                 685             


Tyr Val Val Val Asp Gln Gln Lys Thr Leu Ala Leu Lys Ser Thr Arg 
    690                 695                 700                 


Glu Ala Trp Thr Asp Gly Arg Gln Ser Thr Glu Ser Glu Thr Pro Ala 
705                 710                 715                 720 


Lys Ser Val Lys 
                


<210> 11
<211> 7836
<212> DNA
<213> Homo sapiens

<400> 11
agggggcgga gcgcaaagga cagaagctcc ggcaccgagt cggggcagag tcccgctgag       60

tccgagcgct gctgaggcag ctggcgagac ggcacgtctg gaggcgaggc gggcgcactg      120

aaaggaggcc ggcgcgcccg cggccccggc tcgcgttctg ttcaggttcg tgggcctgca      180

gaggagagac tcgaactcgt ggaacccgcg caccgtggag tctgtccgcc cagtccgtcc      240

ggggtgcgcg accaggagag ctaggttctc gccactgcgc gctcggcagg cgtcggctgt      300

gtcgggagcg cgcccgccgc ccctcagctg cccggcccgg agcccgagac gcgcgcacca      360

tgagcggtgg tgaagtggtc tgctccggat ggctccgcaa gtcccccccg gagaaaaagt      420

tgaagcgtta tgcatggaag aggagatggt tcgtgttacg cagtggccgt ttaactggag      480

atccagatgt tttggaatat tacaaaaatg atcatgccaa gaagcctatt cgtattattg      540

atttaaattt atgtcaacaa gtagatgctg gattgacatt taacaaaaaa gagtttgaaa      600

acagctacat ttttgatatc aacactattg accggatttt ctacttggta gcagacagcg      660

aggaggagat gaataagtgg gttcgttgta tttgtgacat ctgtgggttt aatccaacag      720

aagaagatcc tgtgaagcca cctggcagct ctttacaagc accagctgat ttacctttag      780

ctataaatac agcaccacca tccacccagg cagattcatc ctctgctact ctacctcctc      840

catatcagct aatcaatgtt ccaccacacc tggaaactct tggcattcag gaggatcctc      900

aagactacct gttgctcatc aactgtcaaa gcaagaagcc cgaacccacc agaacgcatg      960

ctgattctgc aaaatccacc tcttctgaaa cagactgcaa tgataacgtc ccttctcata     1020

aaaatcctgc ttcctcccag agcaaacatg gaatgaatgg cttttttcag cagcaaatga     1080

tatacgactc tccaccttca cgtgccccat ctgcttcagt tgactccagc ctttataacc     1140

tgcccaggag ttattcccat gatgttttac caaaggtgtc tccatcaagt actgaagcag     1200

atggagaact ctatgttttt aataccccat ctgggacatc gagtgtagag actcaaatga     1260

ggcatgtatc tattagttat gacattcctc caacacctgg taatacttat cagattccac     1320

gaacatttcc agaaggaacc ttgggacaga catcaaagct agacactatt ccagatattc     1380

ctccacctcg gccaccgaaa ccacatccag ctcatgaccg atctcctgtg gaaacgtgta     1440

gtatcccacg caccgcctca gacactgaca gtagttactg tatccctaca gcagggatgt     1500

cgccttcacg tagtaatacc atttccactg tggatttaaa caaattgcga aaagatgcta     1560

gttctcaaga ctgctatgat attccacgag catttccaag tgatagatct agttcacttg     1620

aaggcttcca taaccacttt aaagtcaaaa atgtgttgac agtgggaagt gtttcaagtg     1680

aagaactgga tgaaaattac gtcccaatga atcccaattc accaccacga caacattcca     1740

gcagttttac agaaccaatt caggaagcaa attatgtgcc aatgactcca ggaacatttg     1800

atttttcctc atttggaatg caagttcctc ctcctgctca tatgggcttc aggtccagcc     1860

caaaaacccc tcccagaagg ccagttcctg ttgcagactg tgaaccaccc cccgtggata     1920

ggaacctcaa gccagacaga aaagtcaagc cagcgccttt agaaataaaa cctttgccag     1980

aatgggaaga attacaagcc ccagttagat ctcccatcac taggagtttt gctcgagact     2040

cttccaggtt tcccatgtcc ccccgaccag attcagtgca tagcacaact tcaagcagtg     2100

actcacacga cagtgaagag aattatgttc ccatgaaccc aaacctgtcc agtgaagacc     2160

caaatctctt tggcagtaac agtcttgatg gaggaagcag ccctatgatc aagcccaaag     2220

gagacaaaca ggtggaatac ttagatctcg acttagattc tgggaaatcc acaccaccac     2280

gtaagcaaaa gagcagtggc tcaggcagca gtgtagcaga tgagagagtg gattatgttg     2340

ttgttgacca acagaagacc ttggctctaa agagtacccg ggaagcctgg acagatggga     2400

gacagtccac agaatcagaa acgccagcga agagtgtgaa atgaaaatat tgccttgcca     2460

tttctgaaca aaagaaaact gaattgtaaa gataaatccc ttttgaagaa tgacttgaca     2520

cttccactct aggtagatcc tcaaatgagt agagttgaag tcaaaggacc tttctgacat     2580

aatcaagcaa tttagactta agtggtgctt tgtggtatct gaacaattca taacatgtaa     2640

ataatgtggg aaaatagtat tgtttagctc ccagagaaac atttgttcca cagttaacac     2700

actcgtagta ttactgtatt tatgcacttt ttcatctaaa acattgttct gggttttccc     2760

aatgtacctt accataattc ctttgggagt tcttgttttt tgtcacacta ctttatataa     2820

caatactaag tcaactaagc tacttttaga tttggaaatt gctgtttaca gtctaacaac     2880

attaaaatga gaggtagatt cacaagttag ctttctacct gaagcttcag gtgataacca     2940

ttagcttata cttggactca tcatttgttg ccttccaaaa tgctgaggat aatgtatgta     3000

ctggtgtcag gacctagttc tctggttaat gtacatttag tttttaatgg tggaactttg     3060

ttatattttg ttaattacag tgtttttggt tcattgagtg aagattctgc cgggtgggat     3120

cttgcacctt tgaaagactg aataattaca ctaccaagta agcctgcaaa tcattgatgg     3180

catgcagtga tgatgtgctc ttacacttgt taacatgtat taagtgttat ttgcaaaagg     3240

tagattatgt aaccaatcag gtacgtacca ggcagtgatg tgctaataca ctgatcaggt     3300

ttagacaatg agctttggtt gtgttcttgt tagtcctaat attggttttc agtttggaat     3360

taataaagca gttgacattc actgttagtt acagcaacat actgtgattt ttaattagat     3420

agtaattcag atttattact ctatgaaatt ctgtcttttg acaccatagt gccctttcta     3480

tgattttttt tacttaatat tcttcttggc cttatattta attccctatg caattaatat     3540

tttatatctg cattttttta aaaaaaatag atgttatata agtgattctc gtatgtagca     3600

cctgttgctt ttccactgaa agaattacgg attttgtact gtgatttata ttcactgccc     3660

caattcaaga aatattggag ccttgctaca atgtgaaatg ttatagtcat ggactccttc     3720

caaccagatt tctgaaaaca ccagagggat ggtataattc tgtctcacct ataacatggt     3780

cctgtgacat agatattaag accacaagtt gtagtgaggc tacaattata ttcgtctgtc     3840

ttggctttgc aacataattt agaaagcacg tatagttgtt ttttaaccaa gttacataca     3900

atctcatgta ctgatttgag acttataaca atttttggag ggggcataga gaaaggagtg     3960

cccacagttg aggcatgacc ccctccattc agacctctaa ctgttgcctg agtacacaga     4020

tgtgccctga tttctggccc attggccata gtactgtgcc taatcaatgt aataggttta     4080

ttttcccaat cctcaaacta aaaatgttca taacaagatg aattgtagac tagtaacatt     4140

tgatgctttt aaatatttgc ttctttttaa acaaaaacta aaacccagaa gtgaattttt     4200

aggtggattt ttaaataaaa aagattgatt gagtttggtg tgcaagctgt tttataatga     4260

aacaacaaaa tgaaatctaa aatcctgaaa tgtgcctaaa ctatcaaaac acacgataca     4320

gctaatgtgt aaagatgcta aattctgtta cttggaggat gaatatattt aagatttaaa     4380

acacaataat aaatacatga ttaattcaaa aataaaaatc tttacagctg cctatcaagg     4440

gtctaaagca cttaatgaat gtttttagtc taacttatca ttaacttttt acaagtcacc     4500

atatttgaag atctgtagca ctctgatttt cagaaaattt ttcattctga ataatttaaa     4560

aatggtgatg tattagaaag gcagtttgct ttagaaaact aaatcacatt gaacattgta     4620

ttagagaatt aaattaaaag tttcttacag agcagtattt tccaaacatt tttagcacta     4680

gaatcttttt agatgaaatt ttatgtataa ccccaataca taaagcctga aaactcaatt     4740

ttatcaatat aaatgtattt tgggttcaca tttatgctta ttcattttgg ctcattacta     4800

agcataataa gattctgagt tatttctgaa taacacaaat gtggagttat acatagttga     4860

tgaaaccagc agccaattta tagctatgcc ctgttttatt tgtatactat caagaaaatt     4920

ttgattcaca caaatgtaag caaaaataat aggttttaaa catacatctc aggaaattct     4980

ttaattagag atagctaaag ttattcaagg tctatacaaa aataagttat cctggtagtg     5040

gaagttaata cataagcagt ctccagtgtg gtaaagtagg gtatgtaaca catcagaatg     5100

tgcgttttta ttaggtttta aaatatgcac gtataaaaac taaatttgaa tcaaaccctt     5160

ttaactcacc tccaagaagc tagactttgg ccaggaatgg gctaaaaacc actggttaac     5220

gatgtgacag ttatgatctt ggagattgga aatctttctt ccacattaga gttctttacc     5280

ttaattcctt attctgaaaa attgtaagat tttatgaagg tttgaatact gaagcacagt     5340

tctgctttca aaaattaaaa ttcaaacttg aaaaagctgt ttaacccatg gaagatatca     5400

tttagtaaga tgtaaaagat tttttaaatc tacacttcag tttatacatc tttatcatta     5460

tcaatactat ataagttact gtgagcattt tagagaattc cataaaggta ctatgagtgt     5520

gtctgtatgt gtgtgtatat atagcattgt atttaatcat agactaaatt taatttgata     5580

tagaaatact actttacttg tacattaagg tcataatttc tgctggactc ttttatattt     5640

aattaatggg gattatagtc ttccttcata aatgcattta aacctgaaat tgaacaccag     5700

tgtttttctt tttctactta tgggaagttg tctgcttccc cctttagaga aaacagtatt     5760

tttatatttt gttaaaatat taactacttt atgcctacac actatgctgt agatactgat     5820

cataattctt gggtgttcac aaacactcct agtgcctctt ttttggcccg ttgaaagtgt     5880

tggtattact actttcacta cagagccttt ggccctctaa taatgctgag gtgggctgat     5940

ccttcccatt tctgtcttcg ggtcattctg gtaggtcttc tcctccactg tcaagtaagc     6000

aatcaggtcc gtgacaggga ttggacatat gaacaaatta agtggataca cacagtgaga     6060

aagatacatg cattctatgg taacaactac tgtcaataac atctgatgtt acatgcacat     6120

ttatatatat ataattttaa aaactgaact atgagaagcc atggtataaa tgaatattgt     6180

ggacatcatg gacttgatat gatagaaatc aattgtcagc ttgagaaagt tgtttttaat     6240

ctgtctaaat agttcatgca ttactacagt taaaaatagt ttcatttgtc ttctatagac     6300

ttaattttat tccggttcag tataatctct gttaacagag tttcagcaaa ctgattggtc     6360

aaggtattaa catagcttct acttccttta cttaaaaaga tgtggtttta tgtaagttct     6420

tgattactga tgatcatccc aaattttgac aacaaaatca tatgtataaa tttatttctc     6480

ccctcttgtt catcatcttt tgtaaaggtc ccattgtaga tcttttctgc taccaaataa     6540

aacttttcaa acaatttggt ttcaagacct taaatagaca agttggatac taagattgtg     6600

aactgataag gacatataaa tttatatttc cagcccttcc ttagagtctt tatctgcatc     6660

aaaaacccaa ttctgccatt aactgtgctt cccagtccca cctctatatg tcactcattt     6720

tctgcaacaa agatctcact aaatcatgtt gaaacacaag tcatgatcct ctctaagtaa     6780

atagaaaaag ctccctggaa aaactctgtt gccacatgca cgtgccctgt tactcctcca     6840

gccagccagt gctgccagca ttttattgtg taaaagtcca aataaataag ggcctgcatg     6900

caacctttat cttcagaaac taggttttat atgtaaaatg tgacttggga aatgattctg     6960

tttattaact ggctgggatt tttcatttct atgaaagttt caaacatctc cagtacttta     7020

taaaatccca acaattgctg taagtcagca ctttggtcca ctcagcccac ccagcccact     7080

tgcaactctg actcttcact gaatcatatt tgggaagttt gggtagggtg aggctatctt     7140

cttcaagatt attttctcat atgtctgtct gtcaccttgt aaaccatgag actcctgggt     7200

atttgcatgt aacttctttg aggaagttac caccatctct gatatagaca cactttttga     7260

gttgcagttt ctgttagaat tttttggaga ctaacttgcc aattctgtga atgttattga     7320

atatttaaaa agctgggtct gtaatgggag gcattttatt agctgttgtg attgggtaac     7380

atgtcccctt agatttcctg atttaaaatt atacaaaatt actatttttg ataaaataaa     7440

ggaacaccta cagaaaatta agtttctaag atgtttctat acttcattag aaaagatttt     7500

attactatta cttatggtta ttggtgatta acacttaatg cgtctcctct gattttgtgt     7560

tccatgaggt gcttggaaca tttggagtgc tctgtgcgag ggacatacag tgatatagga     7620

aatttaaaaa ttaaaataat acccaaaacc cactttatca gatatggtat tgtgatggtt     7680

aatattatgt gtcaacttgg tgaggctatg gcgcccatgt gtttggtcaa acactagcct     7740

agatgttgct gtgaatatat tttgtagatg tgattaacat ttacaatcag ttgattttaa     7800

gtaaagcaga ttctcatcca aaaaaaaaaa aaaaaa                               7836


<210> 12
<211> 894
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Ser Thr Leu Ser Ala Ser Asn Met Gln Asp Pro Ser Ser Ser 
1               5                   10                  15      


Pro Leu Glu Lys Cys Leu Gly Ser Ala Asn Gly Asn Gly Asp Leu Asp 
            20                  25                  30          


Ser Glu Glu Gly Ser Ser Leu Glu Glu Thr Gly Phe Asn Trp Gly Glu 
        35                  40                  45              


Tyr Leu Glu Glu Thr Gly Ala Ser Ala Ala Pro His Thr Ser Phe Lys 
    50                  55                  60                  


His Val Glu Ile Ser Ile Gln Ser Asn Phe Gln Pro Gly Met Lys Leu 
65                  70                  75                  80  


Glu Val Ala Asn Lys Asn Asn Pro Asp Thr Tyr Trp Val Ala Thr Ile 
                85                  90                  95      


Ile Thr Thr Cys Gly Gln Leu Leu Leu Leu Arg Tyr Cys Gly Tyr Gly 
            100                 105                 110         


Glu Asp Arg Arg Ala Asp Phe Trp Cys Asp Val Val Ile Ala Asp Leu 
        115                 120                 125             


His Pro Val Gly Trp Cys Thr Gln Asn Asn Lys Val Leu Met Pro Pro 
    130                 135                 140                 


Asp Ala Ile Lys Glu Lys Tyr Thr Asp Trp Thr Glu Phe Leu Ile Arg 
145                 150                 155                 160 


Asp Leu Thr Gly Ser Arg Thr Ala Pro Ala Asn Leu Leu Glu Gly Pro 
                165                 170                 175     


Leu Arg Gly Lys Gly Pro Ile Asp Leu Ile Thr Val Gly Ser Leu Ile 
            180                 185                 190         


Glu Leu Gln Asp Ser Gln Asn Pro Phe Gln Tyr Trp Ile Val Ser Val 
        195                 200                 205             


Ile Glu Asn Val Gly Gly Arg Leu Arg Leu Arg Tyr Val Gly Leu Glu 
    210                 215                 220                 


Asp Thr Glu Ser Tyr Asp Gln Trp Leu Phe Tyr Leu Asp Tyr Arg Leu 
225                 230                 235                 240 


Arg Pro Val Gly Trp Cys Gln Glu Asn Lys Tyr Arg Met Asp Pro Pro 
                245                 250                 255     


Ser Glu Ile Tyr Pro Leu Lys Met Ala Ser Glu Trp Lys Cys Thr Leu 
            260                 265                 270         


Glu Lys Ser Leu Ile Asp Ala Ala Lys Phe Pro Leu Pro Met Glu Val 
        275                 280                 285             


Phe Lys Asp His Ala Asp Leu Arg Ser His Phe Phe Thr Val Gly Met 
    290                 295                 300                 


Lys Leu Glu Thr Val Asn Met Cys Glu Pro Phe Tyr Ile Ser Pro Ala 
305                 310                 315                 320 


Ser Val Thr Lys Val Phe Asn Asn His Phe Phe Gln Val Thr Ile Asp 
                325                 330                 335     


Asp Leu Arg Pro Glu Pro Ser Lys Leu Ser Met Leu Cys His Ala Asp 
            340                 345                 350         


Ser Leu Gly Ile Leu Pro Val Gln Trp Cys Leu Lys Asn Gly Val Ser 
        355                 360                 365             


Leu Thr Pro Pro Lys Gly Tyr Ser Gly Gln Asp Phe Asp Trp Ala Asp 
    370                 375                 380                 


Tyr His Lys Gln His Gly Ala Gln Glu Ala Pro Pro Phe Cys Phe Arg 
385                 390                 395                 400 


Asn Thr Ser Phe Ser Arg Gly Phe Thr Lys Asn Met Lys Leu Glu Ala 
                405                 410                 415     


Val Asn Pro Arg Asn Pro Gly Glu Leu Cys Val Ala Ser Val Val Ser 
            420                 425                 430         


Val Lys Gly Arg Leu Met Trp Leu His Leu Glu Gly Leu Gln Thr Pro 
        435                 440                 445             


Val Pro Glu Val Ile Val Asp Val Glu Ser Met Asp Ile Phe Pro Val 
    450                 455                 460                 


Gly Trp Cys Glu Ala Asn Ser Tyr Pro Leu Thr Ala Pro His Lys Thr 
465                 470                 475                 480 


Val Ser Gln Lys Lys Arg Lys Ile Ala Val Val Gln Pro Glu Lys Gln 
                485                 490                 495     


Leu Pro Pro Thr Val Pro Val Lys Lys Ile Pro His Asp Leu Cys Leu 
            500                 505                 510         


Phe Pro His Leu Asp Thr Thr Gly Thr Val Asn Gly Lys Tyr Cys Cys 
        515                 520                 525             


Pro Gln Leu Phe Ile Asn His Arg Cys Phe Ser Gly Pro Tyr Leu Asn 
    530                 535                 540                 


Lys Gly Arg Ile Ala Glu Leu Pro Gln Ser Val Gly Pro Gly Lys Cys 
545                 550                 555                 560 


Val Leu Val Leu Lys Glu Val Leu Ser Met Ile Ile Asn Ala Ala Tyr 
                565                 570                 575     


Lys Pro Gly Arg Val Leu Arg Glu Leu Gln Leu Val Glu Asp Pro His 
            580                 585                 590         


Trp Asn Phe Gln Glu Glu Thr Leu Lys Ala Lys Tyr Arg Gly Lys Thr 
        595                 600                 605             


Tyr Arg Ala Val Val Lys Ile Val Arg Thr Ser Asp Gln Val Ala Asn 
    610                 615                 620                 


Phe Cys Arg Arg Val Cys Ala Lys Leu Glu Cys Cys Pro Asn Leu Phe 
625                 630                 635                 640 


Ser Pro Val Leu Ile Ser Glu Asn Cys Pro Glu Asn Cys Ser Ile His 
                645                 650                 655     


Thr Lys Thr Lys Tyr Thr Tyr Tyr Tyr Gly Lys Arg Lys Lys Ile Ser 
            660                 665                 670         


Lys Pro Pro Ile Gly Glu Ser Asn Pro Asp Ser Gly His Pro Lys Pro 
        675                 680                 685             


Ala Arg Arg Arg Lys Arg Arg Lys Ser Ile Phe Val Gln Lys Lys Arg 
    690                 695                 700                 


Arg Ser Ser Ala Val Asp Phe Thr Ala Gly Ser Gly Glu Glu Ser Glu 
705                 710                 715                 720 


Glu Glu Asp Ala Asp Ala Met Asp Asp Asp Thr Ala Ser Glu Glu Thr 
                725                 730                 735     


Gly Ser Glu Leu Arg Asp Asp Gln Thr Asp Thr Ser Ser Ala Glu Val 
            740                 745                 750         


Pro Ser Ala Arg Pro Arg Arg Ala Val Thr Leu Arg Ser Gly Ser Glu 
        755                 760                 765             


Pro Val Arg Arg Pro Pro Pro Glu Arg Thr Arg Arg Gly Arg Gly Ala 
    770                 775                 780                 


Pro Ala Ala Ser Ser Ala Glu Glu Gly Glu Lys Cys Pro Pro Thr Lys 
785                 790                 795                 800 


Pro Glu Gly Thr Glu Asp Thr Lys Gln Glu Glu Glu Glu Arg Leu Val 
                805                 810                 815     


Leu Glu Ser Asn Pro Leu Glu Trp Thr Val Thr Asp Val Val Arg Phe 
            820                 825                 830         


Ile Lys Leu Thr Asp Cys Ala Pro Leu Ala Lys Ile Phe Gln Glu Gln 
        835                 840                 845             


Asp Ile Asp Gly Gln Ala Leu Leu Leu Leu Thr Leu Pro Thr Val Gln 
    850                 855                 860                 


Glu Cys Met Glu Leu Lys Leu Gly Pro Ala Ile Lys Leu Cys His Gln 
865                 870                 875                 880 


Ile Glu Arg Val Lys Val Ala Phe Tyr Ala Gln Tyr Ala Asn 
                885                 890                 


<210> 13
<211> 7922
<212> DNA
<213> Homo sapiens

<400> 13
cgccttgtgt gtgctggatc ctgcgcgggt agatccccga gtaatttttt ctgcaggatg       60

aattaagaga agagacactt gctcatcagg catggagagc actttgtcag cttccaatat      120

gcaagaccct tcatcttcac ccttggaaaa gtgtctcggc tcagctaatg gaaatggaga      180

ccttgattct gaagaaggct caagcttgga ggaaactggc tttaactggg gagaatattt      240

ggaagagaca ggagcaagtg ctgctcccca cacatcattc aaacacgttg aaatcagcat      300

tcagagcaac ttccagccag gaatgaaatt ggaagtggct aataagaaca acccggacac      360

gtactgggtg gccacgatca ttaccacgtg cgggcagctg ctgcttctgc gctactgcgg      420

ttacggggag gaccgcaggg ccgacttctg gtgtgacgta gtcatcgcgg atttgcaccc      480

cgtggggtgg tgcacacaga acaacaaggt gttgatgccg ccggacgcaa tcaaagagaa      540

gtacacagac tggacagaat ttctcatacg tgacttgact ggttcgagga cagcacccgc      600

caacctcctg gaaggtcctc tgcgagggaa aggccctata gacctcatta cagttggttc      660

cttaatagaa cttcaggatt cccagaaccc ttttcagtac tggatagtta gtgtgattga      720

aaatgttgga ggaagattac gccttcgcta tgtgggattg gaggacactg aatcctatga      780

ccagtggttg ttttacttgg attacagact tcgaccagtt ggttggtgtc aagagaataa      840

atacagaatg gacccacctt cagaaatcta tcctttgaag atggcctctg aatggaaatg      900

tactctggaa aaatccctta ttgatgctgc caaatttcct cttccaatgg aagtgtttaa      960

ggatcacgca gatttgcgaa gccatttctt cacagttggg atgaagcttg agacagtgaa     1020

tatgtgcgag cccttttaca tctctcctgc gtcggtgact aaggttttta acaatcactt     1080

ttttcaagtg actattgatg acctaagacc tgaaccaagt aaactgtcaa tgctgtgcca     1140

tgcagattct ttggggattt tgccagtaca gtggtgcctt aaaaatggag tcagcctcac     1200

tcctcccaaa ggttactctg gccaggactt cgactgggca gattatcaca agcagcatgg     1260

ggcgcaggaa gcccctccct tctgcttccg aaatacatca ttcagtcgag gtttcacaaa     1320

gaacatgaaa cttgaagctg tgaaccccag gaatccagga gaactgtgtg tggcctccgt     1380

tgtgagtgtg aaggggcggc taatgtggct tcacctggaa gggctgcaga ctcctgttcc     1440

agaggtcatt gttgatgtgg aatccatgga catcttccca gtgggctggt gtgaagccaa     1500

ttcttatcct ttgactgcac cacacaaaac agtctcacaa aagaagagaa agattgcagt     1560

cgtgcaacca gagaaacaat tgccgcccac agtgcctgtt aagaaaatac ctcatgacct     1620

ttgtttattc cctcacctgg acaccacagg aaccgtcaac gggaaatact gctgtcctca     1680

gctcttcatc aaccacaggt gtttctcagg cccttacctg aacaaaggaa ggattgcaga     1740

gctacctcag tcggtgggac cgggcaaatg cgtgctggtt cttaaagagg ttcttagcat     1800

gataatcaac gcagcctaca agcctggaag ggtattaaga gaattacagc tggtagaaga     1860

tccccactgg aatttccagg aagagacgct gaaggccaaa tacagaggca aaacatacag     1920

ggctgtggtc aaaatcgtac ggacatctga ccaagtcgca aatttctgcc gccgagtctg     1980

tgccaagcta gagtgctgtc caaatttgtt tagtcctgtg ctgatatctg aaaactgccc     2040

agagaactgc tccattcata ccaaaaccaa atacacctat tactatggaa agagaaagaa     2100

gatctccaag ccccccatcg gggaaagcaa ccccgacagc ggacacccca aacccgccag     2160

gcggaggaag cgacggaaat ccattttcgt gcagaagaaa cggaggtctt ctgccgtgga     2220

cttcaccgcg ggctcggggg aggaaagtga agaggaggac gctgacgcca tggacgatga     2280

caccgccagt gaggagaccg gctccgagct ccgggatgac cagacggaca cctcgtcggc     2340

ggaggtgccc tcggcccggc cccggagggc cgtcaccctg cggagcggct cagagcccgt     2400

gcgccggcca cccccagaga ggacacgaag gggccgcggg gcgccggctg cctcctcagc     2460

agaggaaggg gagaagtgcc cgccgaccaa gcccgagggg acagaggaca cgaaacagga     2520

ggaggaggag agactggttc tggagagcaa cccgttggag tggacggtca ccgacgtggt     2580

gaggttcatt aagctgacag actgtgcccc cttggccaag atatttcagg agcaggatat     2640

tgacggccaa gcactcctgc ttctgaccct tccgacggtg caggagtgca tggagctgaa     2700

gctggggcct gccatcaagt tatgccacca gatcgagaga gtcaaagtgg ctttctacgc     2760

ccagtacgcc aactgagtct gccctcggga ggtggcccat tattgctggg atgcggtgtt     2820

ggtaaaggtt tccaggactg aaactttgat tttccgggat atgttaaatg gtacagccac     2880

taagtatcac cagaaaacca gaagcccagg atcttctgcc tccgccagcc tgtgagctgt     2940

ttccatgttt tcaaagcaca gcagcagtcg cttctgggga gtgccagtta aagtcatgca     3000

tcagaccctg ccagacgtgg gcctgcttct tggctcaccc acgttttgcc tttctcctgc     3060

cccaaatcag gcagctccct tggagcaggg tttcctcaga tgaggactgc attctttgaa     3120

aacaaagaat gtcgccaagg aagaaacctc acgccatgct gtagtgtttc ctgtaatcac     3180

acgagcacat ttatatatgc agtttcccat ggataggcgt gtgaccctgg ttgagtggca     3240

cttgcggttt catcttggtg gcaactcctt tgcaatgcag ctggcagcga catccttata     3300

aaaacatgtg ctaaagctct gtcctctgtt agaggtgcct tttaggaata cggggagtga     3360

aggaaggccg gcaggcatct ccatgcaact agatggtttg tttgtttgtt tgtttgtttg     3420

ttgttcattt tgttgtgttt tttgagacag ggtcttgctc tgtcgcccag gttgtaatgc     3480

agtggcgcaa tctcagctca ctgcaacctc tctctcccgg gttcaagtga ttctcctgcc     3540

tcagcctccc aagtagctgg gattacaggc acccaccacc atgcctggct aatttttgta     3600

tttttggtag agacagggtt tcaccatgtt ggtcaggcta gtcttgaact cccaacctca     3660

agtgatctgc ccgcctcggc ctcccaacgt gctgggatta caggtgtgag ccactacgcc     3720

ccggcccaac tggatggttt ttgattgaag cctagaacat ctgtagagac aaactctacc     3780

cagtcttttc tagaccctca actatctcca gtgttgttgt ttaatcgtag ccggatcagg     3840

gagtgagtct tttaggcaaa tgttggatta tatatcaaag gaaaagctta gtttcagaga     3900

ggaggaaggg aaagagatgt gagggaagca tttcatcaac cagctacgtc ccccttagaa     3960

ggatcactgc agcaggtcac cgagcaggag tccctctgag cgtcccttct gtctcgttct     4020

gccctagctg gcagcatatg aaccaggcat gatgcagcag gagcagtgaa tctggagtca     4080

gccacttggc accctggttt cgctgagaac aaactctgag atcttgggtg acttctcatc     4140

actctggacc tccattcctg tgaagtgaca ggtgtggacc ctgagggtgc ggtggtgagc     4200

acactgtctc ctgctggcat tcaccccact catgctggaa aggaagatcc agatcgtaca     4260

aaaattagaa aaagaaagaa taagaagggt ctggtcccag ttctgactcg gccattctta     4320

cagctctttc tggctttgag tttgcttgtg gaatttcctg ggcagttgtg ttaaatccgc     4380

caggtcacgt gcagacaaag ctgtggctgc gagagttggc tggcctcttg gaccagaagc     4440

catctccata tcctcatgag cgattccata tctccactca gaccctgtgg actacagtgt     4500

tccgctgtgg tggctgccaa gatgccttct taaacttatg caaggaaacc aaaccctccc     4560

acagttccca agcagacact ggaagcagag gcttctcacc cttcctgctt tttcaccaca     4620

atcaccttga gctcgtccct tggactagag tctccacagt tccagtaaaa ttctgcggtg     4680

ggctgatgag ctgcttgcat ttctgtgaca tttccagata tgattctcag tgggattttg     4740

gaaactttga ttgctcaagc tcacccttct taacattctg taatggttac agatgagaat     4800

ggaaaacaca tattttatgg atgaggcgtt ttggtctccc ctgcagtcga tttctagaat     4860

caagttttag agttcggctg atgcatctgc ctggggacct cagatgggag gagtgtgtca     4920

gttgtacccc gacagaaatg tctctgggat ctgtggctgg cttgccccgg gcatctctcc     4980

tttaagctca agttttgaac tctctgcggt tttccacccc tgccttctca gccacatgct     5040

tttggcctta aacgctcagt cttgtggagt tcaactctgt caaacgattg gaaagggcat     5100

ccatttccag atctttggca ttttccccgc gctgactctt tgatgatcct tcactgtggc     5160

cttttcaagc tcagctgttc ctgttgtatt tgagacgagg gtgagggaat gtggtggcca     5220

caaaagaaca gggacttgca gcacaaatgt cacttctgtc tcccttttca gtggtagcac     5280

ggaggaggag gtgctgcgtt ggagggaggg gatcctccag gagctctctg gagcccatct     5340

aggaagctag agtgtgtggc ccgccaggag ctcaggaagg atacagccac tgtcgcaggg     5400

gaaagtgttt gcttcccgtg gagccaagcg cccaagactc tccgtatcct tcaccctgac     5460

agtttaactt cagcgtttct ctgtgcagtt gcggtcacca tgggtgagca ctgtctgtgc     5520

acgtgccagg gaggagatgg ctgggaccac tgcacaggag ggcgcagcct ggcgtcgcca     5580

tgaaagttgt ctctgtgcca tctctccggt ccttgaggag agcccagaaa gattttagga     5640

cccaggaggt gcttttcctc cagctgttgc cagtgtcctt ctgagcctgg attctccggg     5700

gatttccgtc gtggtggatg gacttcacat cagcagcagt tctggtacag aattgtaatg     5760

tgttttcatt tctctgtagg attcacctct caccagcgtc tgtcttaaag gtagggccaa     5820

tttcatggag catttttctg tgtgtgtcct tgttgctttt gccagaaaaa gtggatttga     5880

catgcgtgcc ccgatgccac catagcccct aggccaacaa tgtcatggtc taaacaccaa     5940

aaagtgatgc cccgcattcc ttccctggat ggtaccgttt cttctccgtc tctctttgat     6000

gattctttgg gaccaaagtc ctctccttag tgcgcctact tcctgtgggc atcatgccac     6060

ttggaactta ttggaactgg cccgggagac tctgcagtct gcgccgtttg aaaaccctga     6120

gaaagagatg ccacctcaac ttgaatcatg acagcccatc gctcagtctc accctaaact     6180

catggagctt gtttcagctc ctcacttctt gactgtattt gtactatgtt gaaaaaatat     6240

cctgtccaca aagacataag cctaacaacc tagaaaaaca acagggtact actggcatta     6300

cagaacttct ttgcctttca aaacaaaagc aaaacacagt gaacttcacc acggagctgc     6360

acagcgtggg gaactcatcc atcactttca aaattagagt catttgatcc aagttggagt     6420

cagacacagt atttgagctg cacggcttct gggttctccc accttatttg atcatattcg     6480

aaagattatt tcctgtgttt gctttgattt gttcctcagt acattaaaat gatccacacc     6540

ttgaacactg ccctctctag aaggttgatt ttgatcagcc ttttgaagat gggtgtcgtt     6600

tccctaactt atctcacaga attttgagtg ttgtatttgg caagttctga gatttgcctt     6660

ctgtcttatg ccaaacaccc ctttctaaga gctgtccccg cttagtttta gaagtactag     6720

gggttttcat acttatttta tagaacaccc atttatattt atttctgtat atagaactaa     6780

aaaaaacagt agtgttaaaa atctttgttg tggtttgagc atctttgctg cttttggatt     6840

gagatggcga atcaaggctt cacttcctct ctcttctgtc tttagaaagc tgtgatcgtg     6900

cgtgcaatta tttgaaaggc aacatagtca attaagaaac ctgtagttgt taaggaagaa     6960

attgttggca agatatccat actgcccata tctcgttggt gcaataatta aatagcaaag     7020

gaaatctgta ttggcaacta ttataattca ataattcttt tgtttactgc ccttttctgt     7080

tcaagaattt tctggaaatt actccctttc acatggttga actcttaagt tgaccagttc     7140

tcatagctct atcactagaa tggtttgcag ataccccaaa catactatga taaaatcaaa     7200

ttgtgctact tttgacccat gtaatttacc taaaagttgt aattgctgac agagtactgc     7260

cttgaatttt ggtttaaaac ctctctagtt tcaatgacaa gtaacaactc aaataattcc     7320

atattgtttg aggaagaggc cataatcctt ctgaattgtt ggcactaagt aatgggattt     7380

ggcccagtaa gtatgacggt cgtgtcgcct aaccaacgca gagcagtgct ttttgtgtgg     7440

ctgaagcgat gtgctgacga aaaaaggaaa attctaggac aatcgttggc taaaaatcac     7500

cttaggatga aaaatttgag gcaaattttt ttaaatgaca gaaaaagata atcatctcac     7560

ttgcttgaaa caggagccag catgatctct ggaagcatca actatccctc gtcgtgattg     7620

ttgaaagctc tttcactgtt ttgcattcta gtttgaatag tttgtattga aattggattc     7680

ctatcttgtg tatgtttttg gtgcgtaaaa gggaaaaatt ggtgtcatta cttttgaaat     7740

ttgcaggacg aagggcatgc ttttggtttg ctgtaagatt gtattctgta tatatgtttt     7800

catgtaaata aatgaaaatc tatatcagag ttatatttta atttttattc taaatgaaaa     7860

aaaccctttt tacttcaaaa aaattgtaag ccacattgtt aataaagtaa aaataaattc     7920

ta                                                                    7922


<210> 14
<211> 435
<212> PRT
<213> Homo sapiens

<400> 14
Met Leu Pro Ala Arg Cys Ala Arg Leu Leu Thr Pro His Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Gln Leu Ser Pro Ala Arg Gly His Arg Thr Thr Gly Pro 
            20                  25                  30          


Arg Phe Leu Ile Ser Asp Arg Asp Pro Gln Cys Asn Leu His Cys Ser 
        35                  40                  45              


Arg Thr Gln Pro Lys Pro Ile Cys Ala Ser Asp Gly Arg Ser Tyr Glu 
    50                  55                  60                  


Ser Met Cys Glu Tyr Gln Arg Ala Lys Cys Arg Asp Pro Thr Leu Gly 
65                  70                  75                  80  


Val Val His Arg Gly Arg Cys Lys Asp Ala Gly Gln Ser Lys Cys Arg 
                85                  90                  95      


Leu Glu Arg Ala Gln Ala Leu Glu Gln Ala Lys Lys Pro Gln Glu Ala 
            100                 105                 110         


Val Phe Val Pro Glu Cys Gly Glu Asp Gly Ser Phe Thr Gln Val Gln 
        115                 120                 125             


Cys His Thr Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asp Gly Lys 
    130                 135                 140                 


Pro Ile Ser Gly Ser Ser Val Gln Asn Lys Thr Pro Val Cys Ser Gly 
145                 150                 155                 160 


Ser Val Thr Asp Lys Pro Leu Ser Gln Gly Asn Ser Gly Arg Lys Asp 
                165                 170                 175     


Asp Gly Ser Lys Pro Thr Pro Thr Met Glu Thr Gln Pro Val Phe Asp 
            180                 185                 190         


Gly Asp Glu Ile Thr Ala Pro Thr Leu Trp Ile Lys His Leu Val Ile 
        195                 200                 205             


Lys Asp Ser Lys Leu Asn Asn Thr Asn Ile Arg Asn Ser Glu Lys Val 
    210                 215                 220                 


Tyr Ser Cys Asp Gln Glu Arg Gln Ser Ala Leu Glu Glu Ala Gln Gln 
225                 230                 235                 240 


Asn Pro Arg Glu Gly Ile Val Ile Pro Glu Cys Ala Pro Gly Gly Leu 
                245                 250                 255     


Tyr Lys Pro Val Gln Cys His Gln Ser Thr Gly Tyr Cys Trp Cys Val 
            260                 265                 270         


Leu Val Asp Thr Gly Arg Pro Leu Pro Gly Thr Ser Thr Arg Tyr Val 
        275                 280                 285             


Met Pro Ser Cys Glu Ser Asp Ala Arg Ala Lys Thr Thr Glu Ala Asp 
    290                 295                 300                 


Asp Pro Phe Lys Asp Arg Glu Leu Pro Gly Cys Pro Glu Gly Lys Lys 
305                 310                 315                 320 


Met Glu Phe Ile Thr Ser Leu Leu Asp Ala Leu Thr Thr Asp Met Val 
                325                 330                 335     


Gln Ala Ile Asn Ser Ala Ala Pro Thr Gly Gly Gly Arg Phe Ser Glu 
            340                 345                 350         


Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val His Trp Tyr Phe 
        355                 360                 365             


Ser Gln Leu Asp Ser Asn Ser Ser Asn Asp Ile Asn Lys Arg Glu Met 
    370                 375                 380                 


Lys Pro Phe Lys Arg Tyr Val Lys Lys Lys Ala Lys Pro Lys Lys Cys 
385                 390                 395                 400 


Ala Arg Arg Phe Thr Asp Tyr Cys Asp Leu Asn Lys Asp Lys Val Ile 
                405                 410                 415     


Ser Leu Pro Glu Leu Lys Gly Cys Leu Gly Val Ser Lys Glu Val Gly 
            420                 425                 430         


Arg Leu Val 
        435 


<210> 15
<211> 3740
<212> DNA
<213> Homo sapiens

<400> 15
ataacgggaa ttcccatggc ccgggctcag gcgtccaacc tgctgccgcc tgggccccgc       60

cgagcggagc tagcgccgcg cgcagagcac acgctcgcgc tccagctccc ctcctgcgcg      120

gttcatgact gtgtcccctg accgcagcct ctgcgagccc ccgccgcagg accacggccc      180

gctccccgcc gccgcgaggg ccccgagcga aggaaggaag ggaggcgcgc tgtgcgcccc      240

gcggagcccg cgaaccccgc tcgctgccgg ctgcccagcc tggctggcac catgctgccc      300

gcgcgctgcg cccgcctgct cacgccccac ttgctgctgg tgttggtgca gctgtcccct      360

gctcgcggcc accgcaccac aggccccagg tttctaataa gtgaccgtga cccacagtgc      420

aacctccact gctccaggac tcaacccaaa cccatctgtg cctctgatgg caggtcctac      480

gagtccatgt gtgagtacca gcgagccaag tgccgagacc cgaccctggg cgtggtgcat      540

cgaggtagat gcaaagatgc tggccagagc aagtgtcgcc tggagcgggc tcaagccctg      600

gagcaagcca agaagcctca ggaagctgtg tttgtcccag agtgtggcga ggatggctcc      660

tttacccagg tgcagtgcca tacttacact gggtactgct ggtgtgtcac cccggatggg      720

aagcccatca gtggctcttc tgtgcagaat aaaactcctg tatgttcagg ttcagtcacc      780

gacaagccct tgagccaggg taactcagga aggaaagtct cctttcgatt ctttttaacc      840

ctcaattcag atgacgggtc taagccgaca cccacgatgg agacccagcc ggtgttcgat      900

ggagatgaaa tcacagcccc aactctatgg attaaacact tggtgatcaa ggactccaaa      960

ctgaacaaca ccaacataag aaattcagag aaagtctatt cgtgtgacca ggagaggcag     1020

agtgccctgg aagaggccca gcagaatccc cgtgagggta ttgtcatccc tgaatgtgcc     1080

cctgggggac tctataagcc agtgcaatgc caccagtcca ctggctactg ctggtgtgtg     1140

ctggtggaca cagggcgccc gctgcctggg acctccacac gctacgtgat gcccagttgt     1200

gagagcgacg ccagggccaa gactacagag gcggatgacc ccttcaagga cagggagcta     1260

ccaggctgtc cagaagggaa gaaaatggag tttatcacca gcctactgga tgctctcacc     1320

actgacatgg ttcaggccat taactcagca gcgcccactg gaggtgggag gttctcagag     1380

ccagacccca gccacaccct ggaggagcgg gtagtgcact ggtatttcag ccagctggac     1440

agcaatagca gcaacgacat taacaagcgg gagatgaagc ccttcaagcg ctacgtgaag     1500

aagaaagcca agcccaagaa atgtgcccgg cgtttcaccg actactgtga cctgaacaaa     1560

gacaaggtca tttcactgcc tgagctgaag ggctgcctgg gtgttagcaa agaagtagga     1620

cgcctcgtct aaggagcaga aaacccaagg gcaggtggag agtccaggga ggcaggatgg     1680

atcaccagac acctaacctt cagcgttgcc catggccctg ccacatcccg tgtaacataa     1740

gtggtgccca ccatgtttgc acttttaata actcttactt gcgtgttttg tttttggttt     1800

cattttaaaa caccaatatc taataccaca gtgggaaaag gaaagggaag aaagacttta     1860

ttctctctct tattgtaagt ttttggatct gctactgaca acttttagag ggttttgggg     1920

gggtggggga gggtgttgtt ggggctgaga agaaagagat ttatatgctg tatataaata     1980

tatatgtaaa ttgtatagtt cttttgtaca ggcattggca ttgctgtttg tttatttctc     2040

tccctctgcc tgctgtgggt ggtgggcact ctggacacat agtccagctt tctaaaatcc     2100

aggactctat cctgggccta ctaaacttct gtttggagac tgacccttgt gtataaagac     2160

gggagtcctg caattgtact gcggactcca cgagttcttt tctggtggga ggactatatt     2220

gccccatgcc attagttgtc aaaattgata agtcacttgg ctctcggcct tgtccaggga     2280

ggttgggcta aggagagatg gaaactgccc tgggagagga agggagtcca gatcccatga     2340

atagcccaca caggtaccgg ctctcagagg gtccgtgcat tcctgctctc cggaccccca     2400

aagggcccag cattggtggg tgcaccagta tcttagtgac cctcggagca aattatccac     2460

aaaggatttg cattacgtca ctcgaaacgt tttcatccat gcttagcatc tactctgtat     2520

aacgcatgag aggggaggca aagaagaaaa agacacacag aagggccttt aaaaaagtag     2580

atatttaata tctaagcagg ggaggggaca ggacagaaag cctgcactga ggggtgcggt     2640

gccaacaggg aaactcttca cctccctgca aacctaccag tgaggctccc agagacgcag     2700

ctgtctcagt gccaggggca gattgggtgt gacctctcca ctcctccatc tcctgctgtt     2760

gtcctagtgg ctatcacagg cctgggtggg tgggttgggg gaggtgtcag tcaccttgtt     2820

ggtaacacta aagttgtttt gttggttttt taaaaaccca atactgaggt tcttcctgtt     2880

ccctcaagtt ttcttatggg cttccaggct ttaagctaat tccagaagta aaactgatct     2940

tgggtttcct attctgcctc ccctagaagg gcaggggtga taacccagct acagggaaat     3000

cccggcccag ctttccacag gcatcacagg catcttccgc ggattctagg gtgggctgcc     3060

cagccttctg gtctgaggcg cagctccctc tgcccaggtg ctgtgcctat tcaagtggcc     3120

ttcaggcaga gcagcaagtg gcccttagcg ccccttccca taagcagctg tggtggcagt     3180

gagggaggtt gggtagccct ggactggtcc cctcctcaga tcacccttgc aaatctggcc     3240

tcatcttgta ttccaacccg acatccctaa aagtacctcc acccgttccg ggtctggaag     3300

gcgttggcac cacaagcact gtccctgtgg gaggagcaca accttctcgg gacaggatct     3360

gatggggtct tgggctaaag gaggtccctg ctgtcctgga gaaagtccta gaggttatct     3420

caggaatgac tggtggccct gccccaacgt ggaaaggtgg gaaggaagcc ttctcccatt     3480

agccccaatg agagaactca acgtgccgga gctgagtggg ccttgcacga gacactggcc     3540

ccactttcag gcctggagga agcatgcaca catggagacg gcgcctgcct gtagatgttt     3600

ggatcttcga gatctcccca ggcatcttgt ctcccacagg atcgtgtgtg taggtggtgt     3660

tgtgtggttt tcctttgtga aggagagagg gaaactattt gtagcttgtt ttataaaaaa     3720

taaaaaatgg gtaaatcttg                                                 3740


<210> 16
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
ccaggcgctc aagagaataa caatttctgc tcagtcaaca tcaac                       45


<210> 17
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ctcttgagcg cctggcgttc ggctgccagg gaccttcatg                             40


