                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
 
<120>  COMPOSITIONS AND METHODS COMPRISING SELF-ASSEMBLING 
       PEPTIDE-POLYMER NANOFIBERS FOR SUBLINGUAL IMMUNIZATION

<130>  028193-9304-WO01

<140>  PCT/US18/42762
<141>  2018-07-18

<150>  62/533,910
<151>  2017-07-18

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gln Gln Lys Phe Gln Phe Gln Phe Glu Gln Gln 
1               5                   10      


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Trp Ser Gly Ser Gly Gln Gln Lys Phe Gln Phe Gln Phe Glu Gln Gln 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ser Gly Ser Gly 
1               


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg Ser Gly Ser Gly Gln Gln Lys Phe Gln Phe Gln Phe Glu Gln Gln 
            20                  25                  30          


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (33)..(33)
<223>  Xaa is -NH-(CH2-CH2-O)n-CH2-CH2-OH and n is an integer between 1 
       and 200

<400>  6

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg Ser Gly Ser Gly Gln Gln Lys Phe Gln Phe Gln Phe Glu Gln Gln 
            20                  25                  30          


Xaa 
    


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa is -NH-(CH2-CH2-O)n-CH2-CH2-OH and n is an integer between 1 
       and 200

<400>  7

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg Xaa 
        


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is biotin

<400>  8

Xaa Ser Gly Ser Gly Ile Ser Gln Ala Val His Ala Ala His Ala Glu 
1               5                   10                  15      


Ile Asn Glu Ala Gly Arg 
            20          


<210>  9
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Gly
<222>  (1)..(1)
<223>  Gly may repeat from 1 to 10 times

<400>  9

Gly 
1   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Ser Gly Ser Gly
<222>  (1)..(4)
<223>  Ser Gly Ser Gly may repeat from 1 to 10 times

<400>  10

Ser Gly Ser Gly 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Ser Gly Ser 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ser Ser Ser Ser 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Ser 
1               


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gly Cys 
1           


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gly Gly Ser 
1           


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gly Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Gly 
1               5                   10                  15      


Gly Cys Gly Gly Cys Gly Gly Cys 
            20                  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gly Gly Ala Ala Tyr 
1               5   


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa at position 1 is any amino acid, repeated 0 to 20 times

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa at position 2 is any positively charged amino acid

<220>
<221>  Xaa
<222>  (3)..(5)
<223>  Xaa at positions 3-5 are independently any amino acid

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa at position 6 is any positively charged amino acid

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is any amino acid, repeated 0 to 20 times

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gln Ala Arg Ile Leu Glu Ala Asp Ala Glu Ile Leu Arg Ala Tyr Ala 
1               5                   10                  15      


Arg Ile Leu Glu Ala His Ala Glu Ile Leu Arg Ala Gln 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gln Ala Lys Ile Leu Glu Ala Asp Ala Glu Ile Leu Lys Ala Tyr Ala 
1               5                   10                  15      


Lys Ile Leu Glu Ala His Ala Glu Ile Leu Lys Ala Gln 
            20                  25                  


<210>  22
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Ala Asp Ala Glu Ile Leu Arg Ala Tyr Ala Arg Ile Leu Glu Ala His 
1               5                   10                  15      


Ala Glu Ile Leu Arg Ala Gln 
            20              


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Ala Glu Ala Lys Ala Glu Ala Lys Ala Glu Ala Lys Ala Glu Ala Lys 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ala Glu Ala Glu Ala Glu Ala Glu Ala Lys Lys Glu Ala Lys Lys Glu 
1               5                   10                  15      


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Glu Met Glu Met Lys Met Lys 
1               5               


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Arg Ala Asp Ala Arg Ala Asp Ala Arg Ala Asp Ala Arg Ala Asp Ala 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Arg Ala Arg Ala Arg Asp Arg Asp Arg Ala Arg Ala Arg Asp Arg Asp 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Arg Ala Arg Ala Arg Ala Arg Ala Arg Asp Arg Asp Arg Asp Arg Asp 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Ala Asp Ala Asp Ala Asp Ala Asp Ala Arg Ala Arg Ala Arg Ala Arg 
1               5                   10                  15      


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Arg Ala Asp Ala Arg Ala Asp Ala 
1               5               


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Arg Phe Arg Phe Arg Phe 
1               5       


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Arg Phe Arg Phe Arg Phe Arg Phe 
1               5               


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  34

Lys Leu Asp Leu Lys Leu Asp Leu Lys Leu Asp Leu Lys Leu Asp Leu 
1               5                   10                  15      


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Phe Lys Phe Glu Phe Lys Phe Glu 
1               5               


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Phe Lys Phe Glu Phe Lys Phe Glu Phe Lys Phe Glu 
1               5                   10          


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Phe Glu Phe Glu Phe Lys Phe Lys Phe Glu Phe Glu Phe Lys Phe Lys 
1               5                   10                  15      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethic

<400>  38

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Thr Lys Val Lys Val 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Val Lys Val Lys Val Lys Thr Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Thr Lys Val Lys Val 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Lys Val Lys Val Lys Val Lys Val Lys Asp Pro Pro Ser Val Lys Val 
1               5                   10                  15      


Lys Val Lys Val Lys 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Ser Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Glu Lys Val Lys Val 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Cys Lys Val Lys Val 
            20      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Glu 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Val Glu Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Val Lys Val Glu Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Val Lys Val Lys Val Glu Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Val Lys Val Lys Val Lys Val Glu Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Glu Val Lys 
1               5                   10                  15      


Val Lys Val Lys Val 
            20      


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Val Lys Val Lys Val Lys Val Lys Val Asp Pro Pro Thr Lys Val Lys 
1               5                   10                  15      


Val Glu Val Lys Val 
            20      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gln Gln Arg Gln Gln Gln Gln Gln Glu Gln Gln 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gln Gln Arg Phe Gln Trp Gln Phe Glu Gln Gln 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gln Gln Arg Phe Gln Trp Gln Phe Gln Gln Gln 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Gln Gln Arg Phe Glu Trp Glu Phe Glu Gln Gln 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa at position 3 is Ornithine

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  56

Gln Gln Xaa Phe Xaa Trp Xaa Phe Gln Gln Gln 
1               5                   10      


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Ser Ser Arg Phe Ser Trp Ser Phe Glu Ser Ser 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  58

Gln Gln Arg Phe Xaa Trp Xaa Phe Glu Gln Gln 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Ser Ser Arg Phe Glu Trp Glu Phe Glu Ser Ser 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  60

Ser Ser Arg Phe Xaa Trp Xaa Phe Glu Ser Ser 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa at position 3 is Ornithine

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa at position 9 is Ornithine

<400>  61

Gln Gln Xaa Phe Xaa Trp Xaa Phe Xaa Gln Gln 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  62

Asn Asn Arg Phe Xaa Trp Xaa Phe Glu Gln Gln 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  63

Thr Thr Arg Phe Xaa Trp Xaa Phe Glu Thr Thr 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa at position 5 is Ornithine

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa at position 7 is Ornithine

<400>  64

Gln Gln Arg Gln Xaa Gln Xaa Gln Glu Gln Gln 
1               5                   10      


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Phe Glu Phe Glu Phe Lys Phe Lys Phe Glu Phe Glu Phe Lys Phe Lys 
1               5                   10                  15      


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Phe Glu Phe Glu Ala Lys Phe Lys Phe Glu Phe Glu Phe Lys Phe Lys 
1               5                   10                  15      


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Phe Glu Phe Glu Phe Lys Leu Lys Ile Glu Phe Glu Phe Lys Phe Lys 
1               5                   10                  15      


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Phe Glu Ala Glu Val Lys Leu Lys Ile Glu Leu Glu Val Lys Phe Lys 
1               5                   10                  15      


<210>  69
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gly Glu Ala Glu Val Lys Leu Lys Ile Glu Leu Glu Val Lys Ala Lys 
1               5                   10                  15      


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Gly Glu Ala Glu Val Lys Ile Lys Ile Glu Val Glu Ala Lys Gly Lys 
1               5                   10                  15      


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Ile Glu Val Glu Ala Lys Gly Lys Gly Glu Ala Glu Val Lys Ile Lys 
1               5                   10                  15      


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Ile Glu Leu Glu Val Lys Ala Lys Gly Glu Ala Glu Val Lys Leu Lys 
1               5                   10                  15      


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Ile Glu Leu Glu Val Lys Ala Lys Ala Glu Ala Glu Val Lys Leu Lys 
1               5                   10                  15      


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Ile Glu Ala Glu Gly Lys Gly Lys Ile Glu Gly Glu Ala Lys Ile Lys 
1               5                   10                  15      


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Lys Lys Gln Leu Gln Leu Gln Leu Gln Leu Gln Leu Gln Leu Lys Lys 
1               5                   10                  15      


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Glu Gln Leu Gln Leu Gln Leu Gln Leu Gln Leu Gln Leu Glu 
1               5                   10                  


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Lys Lys Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Lys Lys 
1               5                   10                  15      


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Glu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Glu 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Glu Cys Leu Ser Leu Cys Leu Ser Leu Cys Leu Ser Leu Glu 
1               5                   10                  


