                         SEQUENCE LISTING

<110>  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
 
<120>  ENGINEERED VARIANTS OF HIV-1 ENV FOR PRESENTATION OF QUARTERNARY 
       EPITOPES

<130>  18-804-WO

<140>  PCT/US2018/042610
<141>  2018-07-18

<150>  US 62/534,191
<151>  2017-07-18

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  856
<212>  PRT
<213>  Human immunodeficiency virus

<400>  1

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  2

Asp Tyr Lys Asp Asp Asp 
1               5       


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  3

Gly Ser Gly Ser Gly Gly Ser Gly 
1               5               


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
cgttcagctg aacaatgatg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
tgttggacaa taccagacag                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
gtggtttgtc caaactcatc                                                   20


<210>  7
<211>  855
<212>  PRT
<213>  Human immunodeficiency virus

<400>  7

Met Arg Val Thr Glu Ile Arg Lys Ser Tyr Gln His Trp Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Ile Leu Met Ile Cys Asn Ala Glu Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Arg Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Glu Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Arg Asn Ala Thr Asn Gly Asn Asp Thr Asn Thr 
    130                 135                 140                 


Thr Ser Ser Ser Arg Gly Met Val Gly Gly Gly Glu Met Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Asn Ile Arg Gly Lys Val Gln Lys Glu Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Ile Ala Pro Ile Asp Asn Asn Ser Asn 
            180                 185                 190         


Asn Arg Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
        195                 200                 205             


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
    210                 215                 220                 


Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Lys 
225                 230                 235                 240 


Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
                245                 250                 255     


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
            260                 265                 270         


Glu Val Val Ile Arg Ser Ala Asn Phe Ala Asp Asn Ala Lys Val Ile 
        275                 280                 285             


Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
    290                 295                 300                 


Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe Tyr 
305                 310                 315                 320 


Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Leu 
                325                 330                 335     


Ser Arg Ala Lys Trp Asn Asp Thr Leu Asn Lys Ile Val Ile Lys Leu 
            340                 345                 350         


Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Lys His Ser Ser Gly 
        355                 360                 365             


Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Thr 
385                 390                 395                 400 


Glu Glu Ser Asn Asn Thr Val Glu Asn Asn Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Thr Arg Asp Gly Gly Pro Glu Asp Asn Lys Thr Glu 
    450                 455                 460                 


Val Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly 
            500                 505                 510         


Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ala Met Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        595                 600                 605             


Asn Ala Ser Trp Ser Asn Lys Ser Leu Asn Lys Ile Trp Asp Asn Met 
    610                 615                 620                 


Thr Trp Ile Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Ile Ile 
625                 630                 635                 640 


Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                645                 650                 655     


Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
            660                 665                 670         


Ile Thr Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
        675                 680                 685             


Gly Leu Ile Gly Leu Arg Ile Val Phe Ser Val Leu Ser Ile Val Asn 
    690                 695                 700                 


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro 
705                 710                 715                 720 


Ser Ser Arg Gly Pro Asp Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly 
                725                 730                 735     


Glu Arg Asp Arg Asp Arg Ser Gly Pro Leu Val Asn Gly Phe Leu Ala 
            740                 745                 750         


Leu Ile Trp Val Asp Leu Arg Ser Leu Phe Leu Phe Ser Tyr His Arg 
        755                 760                 765             


Leu Arg Asp Leu Leu Leu Ile Val Met Arg Ile Val Glu Leu Leu Gly 
    770                 775                 780                 


Leu Ala Gly Gly Trp Glu Val Leu Lys Tyr Trp Trp Asn Leu Leu Gln 
785                 790                 795                 800 


Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala 
                805                 810                 815     


Thr Ala Val Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val Leu 
            820                 825                 830         


Gln Arg Ala Val Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Leu Glu Arg Ala Leu Leu 
    850                 855 


<210>  8
<211>  858
<212>  PRT
<213>  Human immunodeficiency virus

<400>  8

Met Arg Val Arg Gly Ile Pro Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Val Gly Asn 
            20                  25                  30          


Leu Asp Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Lys Asn Val Asn Ile Ser Ala Asn Ala Asn Ala Thr 
    130                 135                 140                 


Ala Thr Leu Asn Ser Ser Met Asn Gly Glu Ile Lys Asn Cys Ser Phe 
145                 150                 155                 160 


Asn Thr Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ala Leu 
                165                 170                 175     


Phe Tyr Lys Pro Asp Val Val Pro Leu Asn Gly Gly Glu His Asn Glu 
            180                 185                 190         


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Ile Ile Val Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
        275                 280                 285             


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Lys Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro Gly Gln Thr Phe 
305                 310                 315                 320 


Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg Glu Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Glu Thr Trp Asn Ser Thr Leu Ile Gln Val Lys Glu Lys 
            340                 345                 350         


Leu Arg Glu His Tyr Asn Lys Thr Ile Lys Phe Glu Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asp Thr Thr Lys Leu Phe Asn Glu Thr Lys Leu Phe Asn 
385                 390                 395                 400 


Glu Ser Glu Tyr Val Asp Asn Lys Thr Ile Ile Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala 
            420                 425                 430         


Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Trp Asp Gly Gly Glu Asn Ser Thr Glu Gly Val Phe Arg 
    450                 455                 460                 


Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
465                 470                 475                 480 


Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Lys Ser 
                485                 490                 495     


Lys Arg Lys Val Val Gly Arg Glu Lys Arg Ala Val Gly Leu Gly Ala 
            500                 505                 510         


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
        515                 520                 525             


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
    530                 535                 540                 


Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 
545                 550                 555                 560 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
            580                 585                 590         


Cys Ser Gly Lys Leu Ile Cys Ala Thr Ala Val Pro Trp Asn Ser Ser 
        595                 600                 605             


Trp Ser Asn Lys Ser Leu Gly Asp Ile Trp Asp Asn Met Thr Trp Met 
    610                 615                 620                 


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asn Thr Ile Phe Arg Leu 
625                 630                 635                 640 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
                645                 650                 655     


Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asp Ile Thr Asn 
            660                 665                 670         


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
        675                 680                 685             


Gly Leu Arg Ile Ile Phe Gly Val Leu Ala Ile Val Lys Arg Val Arg 
    690                 695                 700                 


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ile Pro Asn Pro Arg 
705                 710                 715                 720 


Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp 
                725                 730                 735     


Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp 
            740                 745                 750         


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Gln Leu Arg Asp 
        755                 760                 765             


Phe Ile Leu Thr Ala Ala Arg Ala Ala Glu Leu Leu Gly Arg Ser Ser 
    770                 775                 780                 


Leu Arg Gly Leu Gln Arg Gly Trp Glu Val Leu Lys Tyr Leu Gly Asn 
785                 790                 795                 800 


Leu Val Gln Tyr Trp Gly Leu Glu Leu Lys Arg Ser Ala Ile Asn Leu 
                805                 810                 815     


Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Ile 
            820                 825                 830         


Glu Val Ile Gln Arg Ile Cys Arg Ala Ile Arg Tyr Ile Pro Thr Arg 
        835                 840                 845             


Ile Arg Gln Gly Phe Glu Ala Ala Leu Leu 
    850                 855             


<210>  9
<211>  855
<212>  PRT
<213>  Human immunodeficiency virus

<400>  9

Met Arg Val Lys Gly Thr Arg Lys Ser Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Ala Val Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Gly Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Gly Tyr Asp Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Pro Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Glu 
                85                  90                  95      


Asn Asp Met Val Asn Gln Met His Glu Asp Val Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Asn Lys Asn Val Ser Ser Ser Asp Thr Asp Asn 
    130                 135                 140                 


Tyr Lys Glu Thr Met Lys Glu Arg Lys Asn Cys Thr Phe Asn Met Thr 
145                 150                 155                 160 


Thr Glu Leu Arg Asp Lys Asn Gln Lys Lys Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Val Pro Leu Asp Asp Asn Asp Asn Ala Ser Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile 
    210                 215                 220                 


Leu Lys Cys Lys Asn Lys Thr Phe Asn Gly Ile Gly Pro Cys Asn Lys 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Asp Ile Val Ile Arg 
            260                 265                 270         


Ser Glu Asn Ile Thr Asp Asn Ala Lys Thr Ile Ile Val His Leu Asn 
        275                 280                 285             


Glu Ser Val Glu Ile Val Cys Ile Arg Pro Asn Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile 
305                 310                 315                 320 


Val Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Glu Gly Lys Trp 
                325                 330                 335     


Asn Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Ala Glu His Phe Pro 
            340                 345                 350         


Asn Ser Thr Ile Asn Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Ser Gly Leu Phe Asn Gly Thr Tyr Met Asn Asn Asp Thr Lys Ser Asn 
385                 390                 395                 400 


Asp Thr Lys Ser Asn Ser Ser Ser Ile Ile Thr Ile Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Val Tyr Ala 
            420                 425                 430         


Pro Pro Ile Ala Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Ile 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Arg Gly Glu Glu Val Lys Asn Asp Thr 
    450                 455                 460                 


Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser 
465                 470                 475                 480 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala 
                485                 490                 495     


Pro Thr Ala Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Gly Leu Gly Ala Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
    530                 535                 540                 


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
            580                 585                 590         


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro 
        595                 600                 605             


Trp Asn Ser Ser Trp Ser Asn Lys Asn Gln Thr Glu Ile Trp Asp Lys 
    610                 615                 620                 


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
625                 630                 635                 640 


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Lys Asp Leu Leu Glu Leu Asp Lys Trp Gln Asn Leu Trp Ser Trp Phe 
            660                 665                 670         


Asn Ile Thr Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Ala 
705                 710                 715                 720 


Pro Asn Pro Arg Gly Leu Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly 
                725                 730                 735     


Gly Lys Glu Asp Arg Asn Arg Ser Ile Arg Leu Val His Gly Phe Leu 
            740                 745                 750         


Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His 
        755                 760                 765             


Arg Leu Arg Asp Leu Ile Leu Leu Ile Ala Arg Ala Val Glu Leu Leu 
    770                 775                 780                 


Gly Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Ala Gly Ile Val Gln 
785                 790                 795                 800 


Tyr Trp Gly Leu Glu Leu Lys Lys Ser Ala Val Ser Leu Phe Asp Thr 
                805                 810                 815     


Ile Ala Ile Ala Val Ala Glu Arg Thr Asp Arg Ile Ile Gly Leu Ile 
            820                 825                 830         


Gln Gly Ile Cys Arg Ala Ile Cys Asn Ile Pro Arg Arg Ile Arg Gln 
        835                 840                 845             


Gly Phe Glu Ala Ala Leu Gln 
    850                 855 


<210>  10
<211>  859
<212>  PRT
<213>  Human immunodeficiency virus

<400>  10

Met Arg Ala Met Gly Ile Gln Arg Asn Trp Gln Asn Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Leu Ile Cys Cys Ser Ala Ala Gly 
            20                  25                  30          


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala 
        35                  40                  45              


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Arg Glu 
    50                  55                  60                  


Ala His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Ser 
65                  70                  75                  80  


Pro Gln Glu Val Pro Leu Gly Asn Val Thr Glu Glu Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Gln Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
        115                 120                 125             


Leu Asn Cys Ser Asn Ser Asn Asn Ile Pro Ser Val Ser Asn Ile Thr 
    130                 135                 140                 


Asp Asp Met Lys Glu Glu Ile Lys Asn Cys Ser Phe Asn Met Thr Thr 
145                 150                 155                 160 


Glu Leu Lys Asp Lys Lys Gln Asn Val Tyr Ser Leu Phe Tyr Arg Leu 
                165                 170                 175     


Asp Val Val Pro Leu Glu Thr Lys Thr Asn Gln Asn Ser Ser His Ser 
            180                 185                 190         


Arg Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Gly Phe Asn Gly Thr Gly 
225                 230                 235                 240 


Leu Cys Lys Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Lys 
            260                 265                 270         


Val Met Val Arg Ser Glu Asn Ile Thr Asn Asn Ala Lys Asn Ile Ile 
        275                 280                 285             


Ile Gln Phe Asn Asn Ser Val Gln Ile Asn Cys Thr Arg Pro Gly Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Ile His Leu Gly Pro Gly Lys Val Phe Tyr Ala 
305                 310                 315                 320 


Thr Asp Ile Ile Gly Asp Ile Arg Lys Ala His Cys Asn Val Asn Arg 
                325                 330                 335     


Gln Gln Trp Asn Lys Thr Leu Gln Asp Val Ala Thr Gln Leu Arg Thr 
            340                 345                 350         


His Phe Arg Asn Arg Thr Ile Ile Phe Asn Asn Ser Leu Gly Gly Asp 
        355                 360                 365             


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Thr Ser Gly Leu Phe Asn Gly Ile Trp Asn Gly Thr Gln Glu 
385                 390                 395                 400 


Pro Asn Arg Thr Glu Ser Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln Ala Ile Tyr Ala 
            420                 425                 430         


Pro Pro Ile Gln Gly Glu Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Ile Leu Thr Arg Asp Gly Gly Ile Ile Asn Ser Thr Glu Glu Thr Phe 
    450                 455                 460                 


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
465                 470                 475                 480 


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
                485                 490                 495     


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Phe Gly 
            500                 505                 510         


Ala Phe Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
        515                 520                 525             


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
    530                 535                 540                 


Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
545                 550                 555                 560 


Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
                565                 570                 575     


Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
            580                 585                 590         


Gly Cys Ser Gly Lys Phe Ile Cys Thr Thr Thr Val Pro Trp Asn Ser 
        595                 600                 605             


Ser Trp Ser Asn Lys Ser Gln Ser Glu Ile Trp Asp Asn Met Thr Trp 
    610                 615                 620                 


Met Gln Trp Asp Lys Glu Ile Asn Asn Tyr Thr Gln Ile Ile Tyr Asp 
625                 630                 635                 640 


Leu Ile Glu Glu Ser Gln Arg Gln Gln Glu Lys Asn Glu Gln Asp Leu 
                645                 650                 655     


Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser 
            660                 665                 670         


Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu 
        675                 680                 685             


Ile Gly Leu Arg Ile Ala Phe Ala Val Leu Ser Val Ile Asn Arg Val 
    690                 695                 700                 


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro Asn Pro 
705                 710                 715                 720 


Arg Asp Leu Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln 
                725                 730                 735     


Asp Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala 
            740                 745                 750         


Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
        755                 760                 765             


Asp Phe Ile Leu Val Ala Ala Arg Thr Val Glu Leu Leu Gly His Ile 
    770                 775                 780                 


Ser Leu Lys Gly Leu Arg Arg Gly Trp Glu Gly Leu Lys Tyr Leu Gly 
785                 790                 795                 800 


Asn Leu Leu Ser Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala Ile Asn 
                805                 810                 815     


Leu Leu Asp Thr Ile Ala Ile Val Val Ala Glu Trp Thr Asp Arg Ile 
            820                 825                 830         


Ile Glu Ile Gly Gln Arg Leu Cys Arg Ala Ile Ile Asn Ile Pro Arg 
        835                 840                 845             


Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
    850                 855                 


<210>  11
<211>  852
<212>  PRT
<213>  Human immunodeficiency virus

<400>  11

Met Arg Ala Met Gly Ile Gln Met Asn Cys Gln Asn Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Phe Cys Ser Ala Val Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asp Cys Asn Asn Val Thr Asn Asn Gly Thr Ser Asp Met Arg Glu Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg 
145                 150                 155                 160 


Gln Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Ile Val Gln Ile Asn 
                165                 170                 175     


Glu Asp Gln Gly Asn Ser Ser Asn Asn Lys Tyr Arg Leu Ile Thr Cys 
            180                 185                 190         


Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro 
        195                 200                 205             


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
    210                 215                 220                 


Lys Asp Glu Glu Phe Asn Gly Ile Gly Pro Cys Lys Asn Val Ser Thr 
225                 230                 235                 240 


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
                245                 250                 255     


Leu Asn Gly Ser Leu Ala Glu Lys Glu Val Lys Ile Arg Cys Glu Asn 
            260                 265                 270         


Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Val Asn Pro Val 
        275                 280                 285             


Lys Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His 
    290                 295                 300                 


Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Gln Ala His Cys Asn Val Asn Arg Thr Glu Trp Asn Asn Thr 
                325                 330                 335     


Leu His Gln Val Val Glu Gln Leu Arg Lys His Phe Asn Lys Thr Ile 
            340                 345                 350         


Asn Phe Ala Asn Ser Thr Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Asn Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Asn His Thr Ala Ser Met Asn Ser Thr Glu Ser Asn 
385                 390                 395                 400 


Asp Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Arg Gly Val Ile 
            420                 425                 430         


Arg Cys Glu Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly 
        435                 440                 445             


Asn Thr Asn Ser Thr Arg Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
    450                 455                 460                 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
465                 470                 475                 480 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu 
                485                 490                 495     


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Ile Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Ser Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
    610                 615                 620                 


Ser Asn Tyr Thr Gln Ile Ile Tyr Asp Leu Leu Glu Glu Ser Gln Asn 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
        675                 680                 685             


Ala Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Thr His Thr Pro Asn Pro Arg Gly Leu Asp Arg Pro Glu 
705                 710                 715                 720 


Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asn Arg Ser Ile Arg 
                725                 730                 735     


Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Val Ala 
        755                 760                 765             


Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu 
    770                 775                 780                 


Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Ser Tyr Trp Gly 
785                 790                 795                 800 


Arg Glu Leu Arg Ile Ser Ala Thr Asn Leu Leu Asp Thr Ile Ala Ile 
                805                 810                 815     


Val Ile Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Leu 
            820                 825                 830         


Cys Arg Ala Phe Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu 
        835                 840                 845             


Arg Ala Leu Leu 
    850         


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader peptide

<400>  12

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu 
            20              


<210>  13
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-BaL gp160

<400>  13

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Glu Glu Lys Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Arg Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu 
65                  70                  75                  80  


Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu 
        115                 120                 125             


Arg Asn Ala Thr Asn Gly Asn Asp Thr Asn Thr Thr Ser Ser Ser Arg 
    130                 135                 140                 


Gly Met Val Gly Gly Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr 
145                 150                 155                 160 


Thr Asn Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     


Leu Asp Ile Ala Pro Ile Asp Asn Asn Ser Asn Asn Arg Tyr Arg Leu 
            180                 185                 190         


Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Lys Gly Pro Cys Thr Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg 
            260                 265                 270         


Ser Ala Asn Phe Ala Asp Asn Ala Lys Val Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Ile His Ile Gly Pro Gly Arg Ala Phe Tyr Thr Thr Gly Glu Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp 
                325                 330                 335     


Asn Asp Thr Leu Asn Lys Ile Val Ile Lys Leu Arg Glu Gln Phe Gly 
            340                 345                 350         


Asn Lys Thr Ile Val Phe Lys His Ser Ser Gly Gly Asp Pro Glu Ile 
        355                 360                 365             


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
    370                 375                 380                 


Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Thr Glu Glu Ser Asn Asn 
385                 390                 395                 400 


Thr Val Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
                405                 410                 415     


Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile 
            420                 425                 430         


Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr 
        435                 440                 445             


Arg Asp Gly Gly Pro Glu Asp Asn Lys Thr Glu Val Phe Arg Pro Gly 
    450                 455                 460                 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
465                 470                 475                 480 


Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg 
                485                 490                 495     


Arg Val Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe 
            500                 505                 510         


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ala Met 
        515                 520                 525             


Thr Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln 
    530                 535                 540                 


Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
545                 550                 555                 560 


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
                565                 570                 575     


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
            580                 585                 590         


Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser 
        595                 600                 605             


Asn Lys Ser Leu Asn Lys Ile Trp Asp Asn Met Thr Trp Ile Glu Trp 
    610                 615                 620                 


Asp Arg Glu Ile Asn Asn Tyr Thr Ser Ile Ile Tyr Ser Leu Ile Glu 
625                 630                 635                 640 


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
                645                 650                 655     


Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu 
            660                 665                 670         


Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu 
        675                 680                 685             


Arg Ile Val Phe Ser Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly 
    690                 695                 700                 


Tyr Ser Pro Leu Ser Phe Gln Thr His Leu Pro Ser Ser Arg Gly Pro 
705                 710                 715                 720 


Asp Arg Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp 
                725                 730                 735     


Arg Ser Gly Pro Leu Val Asn Gly Phe Leu Ala Leu Ile Trp Val Asp 
            740                 745                 750         


Leu Arg Ser Leu Phe Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu 
        755                 760                 765             


Leu Ile Val Met Arg Ile Val Glu Leu Leu Gly Leu Ala Gly Gly Trp 
    770                 775                 780                 


Glu Val Leu Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu 
785                 790                 795                 800 


Leu Lys Asn Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Val Ala Val 
                805                 810                 815     


Ala Glu Gly Thr Asp Arg Val Ile Glu Val Leu Gln Arg Ala Val Arg 
            820                 825                 830         


Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala 
        835                 840                 845             


Leu Leu 
    850 


<210>  14
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-DU422 gp160

<400>  14

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asn Leu Asp Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp 
                85                  90                  95      


Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Lys Asn Val 
        115                 120                 125             


Asn Ile Ser Ala Asn Ala Asn Ala Thr Ala Thr Leu Asn Ser Ser Met 
    130                 135                 140                 


Asn Gly Glu Ile Lys Asn Cys Ser Phe Asn Thr Thr Thr Glu Leu Arg 
145                 150                 155                 160 


Asp Lys Lys Gln Lys Val Tyr Ala Leu Phe Tyr Lys Pro Asp Val Val 
                165                 170                 175     


Pro Leu Asn Gly Gly Glu His Asn Glu Thr Gly Glu Tyr Ile Leu Ile 
            180                 185                 190         


Asn Cys Asn Ser Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             


Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu 
    210                 215                 220                 


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Val Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Ile Lys Thr Ile Ile Val His Leu Asn Lys 
        275                 280                 285             


Ser Val Glu Ile Lys Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 


Val Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Glu Ala His Cys Asn Ile Ser Arg Glu Thr Trp Asn 
                325                 330                 335     


Ser Thr Leu Ile Gln Val Lys Glu Lys Leu Arg Glu His Tyr Asn Lys 
            340                 345                 350         


Thr Ile Lys Phe Glu Pro Ser Ser Gly Gly Asp Leu Glu Val Thr Thr 
        355                 360                 365             


His Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asp Thr Thr Lys 
    370                 375                 380                 


Leu Phe Asn Glu Thr Lys Leu Phe Asn Glu Ser Glu Tyr Val Asp Asn 
385                 390                 395                 400 


Lys Thr Ile Ile Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn Ile 
            420                 425                 430         


Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Trp Asp Gly Gly 
        435                 440                 445             


Glu Asn Ser Thr Glu Gly Val Phe Arg Pro Gly Gly Gly Asn Met Lys 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Lys Val Val Gly Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Leu Gly Ala Val Leu Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Ala Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Leu Gly 
        595                 600                 605             


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asn Thr Ile Phe Arg Leu Leu Glu Asp Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Gly 
        675                 680                 685             


Val Leu Ala Ile Val Lys Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
    690                 695                 700                 


Phe Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg 
705                 710                 715                 720 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Lys Asp Arg Ser Ile Arg Leu 
                725                 730                 735     


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
            740                 745                 750         


Leu Phe Ser Tyr His Gln Leu Arg Asp Phe Ile Leu Thr Ala Ala Arg 
        755                 760                 765             


Ala Ala Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly 
    770                 775                 780                 


Trp Glu Val Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Gly Leu 
785                 790                 795                 800 


Glu Leu Lys Arg Ser Ala Ile Asn Leu Phe Asp Thr Ile Ala Ile Ala 
                805                 810                 815     


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Ile Gln Arg Ile Cys 
            820                 825                 830         


Arg Ala Ile Arg Tyr Ile Pro Thr Arg Ile Arg Gln Gly Phe Glu Ala 
        835                 840                 845             


Ala Leu Leu 
    850     


<210>  15
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-25711 gp160

<400>  15

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Gly Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Met Pro Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Glu Asn Asp Met Val Asn Gln Met 
                85                  90                  95      


His Glu Asp Val Ile Ser Leu Trp Asp Glu Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Val Asn Lys 
        115                 120                 125             


Asn Val Ser Ser Ser Asp Thr Asp Asn Tyr Lys Glu Thr Met Lys Glu 
    130                 135                 140                 


Arg Lys Asn Cys Thr Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Asn 
145                 150                 155                 160 


Gln Lys Lys Tyr Ala Leu Phe Tyr Lys Leu Asp Ile Val Pro Leu Asp 
                165                 170                 175     


Asp Asn Asp Asn Ala Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
            180                 185                 190         


Leu Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Lys Asn Lys Thr 
    210                 215                 220                 


Phe Asn Gly Ile Gly Pro Cys Asn Lys Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Asp Ile Val Ile Arg Ser Glu Asn Ile Thr Asp Asn 
            260                 265                 270         


Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys 
        275                 280                 285             


Ile Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Thr Phe Tyr Ala Thr Gly Asp Ile Val Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


Tyr Cys Asn Ile Ser Glu Gly Lys Trp Asn Lys Thr Leu Gln Arg Val 
                325                 330                 335     


Ser Glu Lys Leu Ala Glu His Phe Pro Asn Ser Thr Ile Asn Phe Asn 
            340                 345                 350         


Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly Thr 
    370                 375                 380                 


Tyr Met Asn Asn Asp Thr Lys Ser Asn Asp Thr Lys Ser Asn Ser Ser 
385                 390                 395                 400 


Ser Ile Ile Thr Ile Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Glu Val Gly Arg Ala Val Tyr Ala Pro Pro Ile Ala Gly Asn Ile 
            420                 425                 430         


Thr Cys Lys Ser Asn Ile Thr Gly Ile Leu Leu Thr Arg Asp Gly Gly 
        435                 440                 445             


Arg Gly Glu Glu Val Lys Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Glu Ile Lys Pro Leu Gly Val Ala Pro Thr Ala Ala Lys Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Val Gly Leu Gly Ala Val Leu Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu 
                565                 570                 575     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Asn Gln Thr Glu Ile Trp Asp Lys Met Thr Trp Met Gln Trp Asp 
    610                 615                 620                 


Arg Glu Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp 
625                 630                 635                 640 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Glu Leu Asp 
                645                 650                 655     


Lys Trp Gln Asn Leu Trp Ser Trp Phe Asn Ile Thr Asn Trp Leu Trp 
            660                 665                 670         


Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr 
    690                 695                 700                 


Ser Pro Leu Ser Phe Gln Thr Leu Ala Pro Asn Pro Arg Gly Leu Asp 
705                 710                 715                 720 


Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Lys Glu Asp Arg Asn Arg 
                725                 730                 735     


Ser Ile Arg Leu Val His Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu 
            740                 745                 750         


Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Ile Leu 
        755                 760                 765             


Leu Ile Ala Arg Ala Val Glu Leu Leu Gly Gln Arg Gly Trp Glu Ala 
    770                 775                 780                 


Leu Lys Tyr Leu Ala Gly Ile Val Gln Tyr Trp Gly Leu Glu Leu Lys 
785                 790                 795                 800 


Lys Ser Ala Val Ser Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Glu 
                805                 810                 815     


Arg Thr Asp Arg Ile Ile Gly Leu Ile Gln Gly Ile Cys Arg Ala Ile 
            820                 825                 830         


Cys Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
        835                 840                 845             


<210>  16
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-Q769.d22 gp160

<400>  16

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Gly Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Asp Arg Glu Ala His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Ser Pro Gln Glu Val Pro Leu 
65                  70                  75                  80  


Gly Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Gln Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser Asn Ser 
        115                 120                 125             


Asn Asn Ile Pro Ser Val Ser Asn Ile Thr Asp Asp Met Lys Glu Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Lys Asp Lys Lys 
145                 150                 155                 160 


Gln Asn Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Pro Leu Glu 
                165                 170                 175     


Thr Lys Thr Asn Gln Asn Ser Ser His Ser Arg Tyr Arg Leu Ile Asn 
            180                 185                 190         


Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Gly Phe Asn Gly Thr Gly Leu Cys Lys Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Gly Lys Val Met Val Arg Ser Glu 
            260                 265                 270         


Asn Ile Thr Asn Asn Ala Lys Asn Ile Ile Ile Gln Phe Asn Asn Ser 
        275                 280                 285             


Val Gln Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


His Leu Gly Pro Gly Lys Val Phe Tyr Ala Thr Asp Ile Ile Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Ala His Cys Asn Val Asn Arg Gln Gln Trp Asn Lys Thr 
                325                 330                 335     


Leu Gln Asp Val Ala Thr Gln Leu Arg Thr His Phe Arg Asn Arg Thr 
            340                 345                 350         


Ile Ile Phe Asn Asn Ser Leu Gly Gly Asp Leu Glu Ile Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu 
    370                 375                 380                 


Phe Asn Gly Ile Trp Asn Gly Thr Gln Glu Pro Asn Arg Thr Glu Ser 
385                 390                 395                 400 


Asn Asp Thr Ile Thr Leu Gln Cys Arg Ile Lys Gln Ile Ile Asn Met 
                405                 410                 415     


Trp Gln Arg Val Gly Gln Ala Ile Tyr Ala Pro Pro Ile Gln Gly Glu 
            420                 425                 430         


Ile Arg Cys Glu Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly 
        435                 440                 445             


Gly Ile Ile Asn Ser Thr Glu Glu Thr Phe Arg Pro Gly Gly Gly Asp 
    450                 455                 460                 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys 
465                 470                 475                 480 


Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val 
                485                 490                 495     


Glu Arg Glu Lys Arg Ala Val Gly Phe Gly Ala Phe Phe Leu Gly Phe 
            500                 505                 510         


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr 
        515                 520                 525             


Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn 
    530                 535                 540                 


Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val 
545                 550                 555                 560 


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
                565                 570                 575     


Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Phe 
            580                 585                 590         


Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser 
        595                 600                 605             


Gln Ser Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Lys Glu 
    610                 615                 620                 


Ile Asn Asn Tyr Thr Gln Ile Ile Tyr Asp Leu Ile Glu Glu Ser Gln 
625                 630                 635                 640 


Arg Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp 
                645                 650                 655     


Ala Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile 
            660                 665                 670         


Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ala 
        675                 680                 685             


Phe Ala Val Leu Ser Val Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro 
    690                 695                 700                 


Leu Ser Phe Gln Thr His Thr Pro Asn Pro Arg Asp Leu Asp Arg Pro 
705                 710                 715                 720 


Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile 
                725                 730                 735     


Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser 
            740                 745                 750         


Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Val Ala 
        755                 760                 765             


Ala Arg Thr Val Glu Leu Leu Gly His Ile Ser Leu Lys Gly Leu Arg 
    770                 775                 780                 


Arg Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Ser Tyr Trp 
785                 790                 795                 800 


Gly Arg Glu Leu Lys Ile Ser Ala Ile Asn Leu Leu Asp Thr Ile Ala 
                805                 810                 815     


Ile Val Val Ala Glu Trp Thr Asp Arg Ile Ile Glu Ile Gly Gln Arg 
            820                 825                 830         


Leu Cys Arg Ala Ile Ile Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe 
        835                 840                 845             


Glu Arg Ala Leu Leu 
    850             


<210>  17
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5-Q842.d12 gp160

<400>  17

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Val Asp Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Glu Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Lys His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile His Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys Asn Asn Met Val Glu 
                85                  90                  95      


Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asp Cys Asn Asn Val 
        115                 120                 125             


Thr Asn Asn Gly Thr Ser Asp Met Arg Glu Glu Ile Lys Asn Cys Ser 
    130                 135                 140                 


Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Arg Gln Lys Val Tyr Ser 
145                 150                 155                 160 


Leu Phe Tyr Lys Leu Asp Ile Val Gln Ile Asn Glu Asp Gln Gly Asn 
                165                 170                 175     


Ser Ser Asn Asn Lys Tyr Arg Leu Ile Thr Cys Asn Thr Ser Ala Ile 
            180                 185                 190         


Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile Pro Ile His Tyr 
        195                 200                 205             


Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Glu Glu Phe 
    210                 215                 220                 


Asn Gly Ile Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr His 
225                 230                 235                 240 


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
                245                 250                 255     


Ala Glu Lys Glu Val Lys Ile Arg Cys Glu Asn Ile Thr Asn Asn Ala 
            260                 265                 270         


Lys Thr Ile Ile Val Gln Leu Val Asn Pro Val Lys Ile Asn Cys Thr 
        275                 280                 285             


Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln 
    290                 295                 300                 


Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His 
305                 310                 315                 320 


Cys Asn Val Asn Arg Thr Glu Trp Asn Asn Thr Leu His Gln Val Val 
                325                 330                 335     


Glu Gln Leu Arg Lys His Phe Asn Lys Thr Ile Asn Phe Ala Asn Ser 
            340                 345                 350         


Thr Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
        355                 360                 365             


Glu Phe Phe Tyr Cys Asn Thr Thr Asn Leu Phe Asn Ser Thr Trp Asn 
    370                 375                 380                 


His Thr Ala Ser Met Asn Ser Thr Glu Ser Asn Asp Thr Ile Ile Leu 
385                 390                 395                 400 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Gln 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Arg Gly Val Ile Arg Cys Glu Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Thr Asn Ser Thr 
        435                 440                 445             


Arg Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Val Phe Ile Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ser Val 
            580                 585                 590         


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Asn Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln 
    610                 615                 620                 


Ile Ile Tyr Asp Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp 
                645                 650                 655     


Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
            660                 665                 670         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val 
        675                 680                 685             


Ile Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
    690                 695                 700                 


Thr Pro Asn Pro Arg Gly Leu Asp Arg Pro Glu Arg Ile Glu Glu Glu 
705                 710                 715                 720 


Gly Gly Glu Gln Asp Lys Asn Arg Ser Ile Arg Leu Val Ser Gly Phe 
                725                 730                 735     


Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
            740                 745                 750         


His Arg Leu Arg Asp Phe Ile Leu Ile Val Ala Arg Thr Val Glu Leu 
        755                 760                 765             


Leu Gly His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu 
    770                 775                 780                 


Lys Tyr Leu Gly Asn Leu Leu Ser Tyr Trp Gly Arg Glu Leu Arg Ile 
785                 790                 795                 800 


Ser Ala Thr Asn Leu Leu Asp Thr Ile Ala Ile Val Ile Ala Gly Trp 
                805                 810                 815     


Thr Asp Arg Val Ile Glu Ile Gly Gln Arg Leu Cys Arg Ala Phe Leu 
            820                 825                 830         


Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
        835                 840                 845         


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader peptide

<400>  18

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala 
            20                  


