                         SEQUENCE LISTING

<110>  Nucleus Therapeutics Pty Ltd, Yale University
 
<120>  Binding Proteins

<130>  524728PCT

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 KABAT

<400>  1

Asn Tyr Gly Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 (variants 2 - 4, 6 - 8, 10 - 12) KABAT

<400>  2

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 (variants 13 - 19) KABAT

<400>  3

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 KABAT

<400>  4

Arg Gly Leu Leu Leu Asp Tyr 
1               5           


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 (variants 2 - 4, 6 - 8, 10 - 12) KABAT

<400>  5

Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 (variants 13 - 19) KABAT

<400>  6

Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 KABAT

<400>  7

Tyr Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 KABAT

<400>  8

Gln His Ser Arg Glu Phe Pro Trp Thr 
1               5                   


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 IMGT

<400>  9

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 (variants 2 - 4, 6 - 8, 10 - 12) IMGT

<400>  10

Ile Ser Ser Ser Ser Ser Thr Ile 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 (variants 13 - 19) IMGT

<400>  11

Ile Ser Ser Gly Ser Ser Thr Ile 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 IMGT

<400>  12

Ala Arg Arg Gly Leu Leu Leu Asp Tyr 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 (variants 2 - 4, 6 - 8, 10 - 12) IMGT

<400>  13

Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1 (variants 13 - 19) IMGT

<400>  14

Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2 IMGT

<400>  15

Tyr Ala Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3 IMGT

<400>  16

Gln His Ser Arg Glu Phe Pro Trp Thr 
1               5                   


<210>  17
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 2, 6 and 10)

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 3, 7 and 11)

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 4, 8 and 12)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 6 and 10)

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 13, 16 and 19)

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 14 and 17)

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region (variants 15 and 18)

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variants 2, 3 and 4)

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variants 6, 7 and 8)

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variants 10, 11 and 12)

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variants 13, 14 and 15)

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variants 16, 17 and 18)

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region (variant 19)

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence 1

<400>  30

Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence 2

<400>  31

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser 
1               5                   10                  15      


Ser Gly Ser 
            


<210>  32
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 2

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  33
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 3

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  34
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 4

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val 
    130                 135                 140                 


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  35
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 6

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  36
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 7

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  37
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 8

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val 
    130                 135                 140                 


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  38
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 10

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  39
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 11

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  40
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 12

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val 
    130                 135                 140                 


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  41
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 13

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  42
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 14

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  43
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 15

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val 
    130                 135                 140                 


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  44
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 16

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  45
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 17

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  46
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 18

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val 
    130                 135                 140                 


Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Asp Val Lys Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  47
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant 19

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Ala Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser Ser Tyr Ser Tyr Met 
    290                 295                 300                 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Lys 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            340                 345                 350         


Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly 
            420                 425                 430         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  48
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region murine 3E10 (D31N)

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  49
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region murine 3E10 (D31N)

<400>  49

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe His Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  50
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E10 (D31N) murine prototype produced from P. pastoris

<400>  50

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
            20                  25                  30          


Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser 
    50                  55                  60                  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
            180                 185                 190         


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
                245                 250                 255     


Gly Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp 
            260                 265                 270         


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
        275                 280                 285             


Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser 
    290                 295                 300                 


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
            340                 345                 350         


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
        355                 360                 365             


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
    370                 375                 380                 


Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
                405                 410                 415     


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            420                 425                 430         


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
        435                 440                 445             


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
    450                 455                 460                 


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
465                 470                 475                 480 


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Leu Thr Val Ser Ser Leu Glu Gln Lys Leu Ile Ser Glu Glu 
        515                 520                 525             


Asp Leu Asn Ser Ala Val Asp His His His His His His 
    530                 535                 540     


<210>  51
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 2

<400>  51
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatctggc      420

ggaggattgg ttcagcctgg cggctctctg agactgtctt gtgccgcttc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctcca gagacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc ctctgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcgga ggcggcacaa aagtcgagat caagcgggct     1140

gatgctgcac caggtggcgg cggtagtggt ggcggaggaa gtggcggagg cggatctgaa     1200

gtccaattgg ttgaaagcgg cggtggcctt gtgcaacccg gtggaagtct gagactctcc     1260

tgcgctgcct ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcctatatc agctcctcta gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataatg ccaagaatag cctgtatctc     1440

caaatgaact ctctccgcgc tgaggataca gctgtgtact attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggaactacc gtgacagtgt ctagctgatg aattc          1555


<210>  52
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 3

<400>  52
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatcaggt      420

ggcggagttg ttcagcctgg cggctctctg agactgtctt gtgccgcttc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc ctctgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcgga ggcggcacaa aagtcgagat caagcgggct     1140

gatgctgcac caggtggcgg cggatctggt ggcggaggct ctggcggagg cggtagtgaa     1200

gttcagttgg tcgagtcagg cggtggcgtt gtgcaacctg gtggtagtct gaggctgtcc     1260

tgcgctgcct ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaata gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggtactacc gtgacagtgt ccagctgatg aattc          1555


<210>  53
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 4

<400>  53
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatctggc      420

ggtggcgacg tgaaacctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc ctctgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcggt ggcggaacaa aggtcgagat caagcgggct     1140

gatgcagcac ctggcggagg cggttcaggt ggcggaggat caggcggtgg cggtagtgaa     1200

gttcagttgg ttgagtccgg cggaggggat gttaagcctg gcggtagcct gagactctcc     1260

tgcgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaaca gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggtactacc gtgacagtgt ccagctgatg aattc          1555


<210>  54
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 6

<400>  54
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccaggc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggattgg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctcca gagacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggcaag ccccaaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggcggaggca gcggtggcgg cggtagtgaa     1200

gttcagttgg tcgagtcagg cggcggactt gttcaaccag gtggtagcct gagactgagc     1260

tgtgctgcta gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcctatatc agctcctcta gctctaccat ctattatgcc     1380

gatagcgtga aaggccggtt taccatcagc cgggataatg ccaagaatag cctgtatctc     1440

caaatgaact ctctccgcgc tgaggatacc gctgtgtatt attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggcactaca gtgacagtgt ctagctgatg aattc          1555


<210>  55
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 7

<400>  55
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccaggc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggagttg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggcaag ccccaaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggtggtggat caggtggcgg aggcagtgaa     1200

gtccagttgg tggaatcagg cggtggcgtt gtgcaacctg gtggaagtct gaggctgtcc     1260

tgcgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaata gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt ccagctgatg aattc          1555


<210>  56
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 8

<400>  56
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccaggc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggc      420

ggaggcgacg tgaaacctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agtctgtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggcaag ccccaaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac caggcggtgg tggttcaggc ggaggcggta gcggcggagg cggctctgaa     1200

gttcaattgg tggaatcagg tggcggggat gtcaagcctg gtggaagtct gagactcagc     1260

tgtgccgcca gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaaca gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt ccagctgatg aattc          1555


<210>  57
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 10

<400>  57
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggattgg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctcca gagacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc cgggccagca aatctgtgtc caccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggcggtggtt caggcggtgg tggctctgag     1200

gttcagttgg tcgagtcagg cggaggactt gttcaaccag gcggaagcct gagactgagc     1260

tgtgctgcta gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcctatatc agctcctcta gctctaccat ctattatgcc     1380

gatagcgtga aaggccggtt taccatcagc cgggataatg ccaagaatag cctgtatctc     1440

caaatgaact ctctccgcgc tgaggatacc gctgtgtatt attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggcactaca gtgacagtgt ctagctgatg aattc          1555


<210>  58
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 11

<400>  58
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggagttg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc cgggccagca aatctgtgtc caccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggtggtggat caggtggcgg aggcagtgaa     1200

gtccagttgg tggaatcagg cggtggcgtt gtgcaacctg gtggaagtct gaggctgtcc     1260

tgcgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaata gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt ccagctgatg aattc          1555


<210>  59
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 12

<400>  59
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctccaa gtccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggc      420

ggaggcgacg tgaaacctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccagctc ctccaccatc tactacgccg actccgtgaa gggcagattc      600

accatctctc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc ctctgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc cgggccagca aatctgtgtc caccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ctggctccgg aagcggcaca     1020

gactttacac tcaccattag ctccctgcag ccagaagatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac caggcggtgg tggttcaggc ggaggcggta gcggcggagg cggctctgaa     1200

gttcaattgg tggaatcagg tggcggggat gtcaagcctg gtggaagtct gagactcagc     1260

tgtgccgcca gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccagca gctctaccat ctattatgct     1380

gacagcgtga aaggccggtt taccatcagc cgggataaca gcaagaatac tctgtatctc     1440

caaatgaaca gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt ccagctgatg aattc          1555


<210>  60
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 13

<400>  60
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatctggc      420

ggaggattgg ttcagcctgg cggctctctg agactgtctt gtgccgcttc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatctctc gggacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc tagcgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcgga ggcggcacaa aagtcgagat caagcgggct     1140

gatgctgcac caggtggcgg cggtagtggt ggcggaggaa gtggcggagg cggatctgaa     1200

gtccaattgg ttgaaagcgg cggtggcctt gtgcaacccg gtggaagtct gagactctcc     1260

tgcgctgcct ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcatatatc tccagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatcagc agagataatg ccaagaacag cctctacctc     1440

caaatgaact cactgcgcgc tgaggataca gctgtgtact attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggaactacc gtgacagtgt cctcctgatg aattc          1555


<210>  61
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 14

<400>  61
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatcaggt      420

ggcggagttg ttcagcctgg cggctctctg agactgtctt gtgccgcttc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatcagcc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc tagcgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcgga ggcggcacaa aagtcgagat caagcgggct     1140

gatgctgcac caggtggcgg cggatctggt ggcggaggct ctggcggagg cggtagtgaa     1200

gttcagttgg tcgagtcagg cggtggcgtt gtgcaacctg gtggtagtct gaggctgtcc     1260

tgcgctgcct ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agcagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatctcc agagacaaca gcaagaatac tctgtatctc     1440

caaatgaata gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggtactacc gtgacagtgt cctcctgatg aattc          1555


<210>  62
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 15

<400>  62
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccagcc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggatgc cgctacctac tactgccagc actccagaga gttcccttgg      300

acctttggcg gaggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggaagcggag gcggaggttc tggtggtggt ggatctgaag tgcagctggt ggaatctggc      420

ggtggcgacg tgaaacctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatcagcc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggcacaacag tgaccgtgtc tagcgcttcc accaagggac cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cctgggcagc caccaaaact gctgatcaaa      960

tacgctagct acctcgagag cggcgtgcca agcagatttt ctggctccgg cagcggcaca     1020

gactttacac tcaccattag ctccctgcaa ccagaggacg ctgccaccta ttattgtcag     1080

cactcccgcg aatttccatg gaccttcggt ggcggaacaa aggtcgagat caagcgggct     1140

gatgcagcac ctggcggagg cggttcaggt ggcggaggat caggcggtgg cggtagtgaa     1200

gttcagttgg ttgagtccgg cggaggggat gttaagcctg gcggtagcct gagactctcc     1260

tgcgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agcagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatctcc agagacaaca gcaagaatac tctgtatctc     1440

caaatgaaca gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggtactacc gtgacagtgt cctcctgatg aattc          1555


<210>  63
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 16

<400>  63
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcttccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggattgg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatctctc gggacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc tagcgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc agagccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ccggaagcgg ctctggaaca     1020

gactttacac tcaccattag ctccctccag ccagaggatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggcggtggtt caggcggtgg tggctctgag     1200

gttcagttgg tcgagtcagg cggaggactt gttcaaccag gcggaagcct gagactgagc     1260

tgtgctgcta gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcatatatc tccagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatcagc agagataatg ccaagaacag cctctatctc     1440

caaatgaact ctctccgcgc tgaggatacc gctgtgtatt attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggcactaca gtgacagtgt cctcctgatg aattc          1555


<210>  64
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 17

<400>  64
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcttccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggagttg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatcagcc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc tagcgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc agagccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ccggaagcgg ctctggaaca     1020

gactttacac tcaccattag ctccctccag ccagaggatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggtggtggat caggtggcgg aggcagtgaa     1200

gtccagttgg tggaatcagg cggtggcgtt gtgcaacctg gtggaagtct gaggctgtcc     1260

tgcgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatctcc agagacaaca gcaagaatac tctgtatctc     1440

caaatgaata gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt cctcctgatg aattc          1555


<210>  65
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 18

<400>  65
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcttccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggcaaggc ccctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggc      420

ggaggcgacg tgaaacctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg agaaaggcct ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatcagcc gggacaactc caagaacacc ctgtacctgc agatgaactc cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc tagcgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtctgct      840

tccgtgggag atcgcgtgac aatcacatgc agagccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggaaag ctcccaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ccggaagcgg ctctggaaca     1020

gactttacac tcaccattag ctccctccag ccagaggatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac caggcggtgg tggttcaggc ggaggcggta gcggcggagg cggctctgaa     1200

gttcaattgg tggaatcagg tggcggggat gtcaagcctg gtggaagtct gagactcagc     1260

tgtgccgcca gcggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

gagaagggac ttgagtgggt ttcctatatc agctccggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatctcc agagacaaca gcaagaatac tctgtatctc     1440

caaatgaaca gcctgcgcgc cgaggataca gctgtgtatt attgcgccag acggggactc     1500

ctgctggatt actggggaca aggcactaca gtgacagtgt cctcctgatg aattc          1555


<210>  66
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 19

<400>  66
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccaggc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggattgg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatctctc gggacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc tagcgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggcaag ccccaaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ccggaagcgg ctctggaaca     1020

gactttacac tcaccattag ctccctccag ccagaggatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggcggaggca gcggtggcgg cggtagtgaa     1200

gttcagttgg tcgagtcagg cggcggactt gttcaaccag gtggtagcct gagactgagc     1260

tgtgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcatatatc tccagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatcagc agagataatg ccaagaacag cctctacctc     1440

caaatgaact cactgcgcgc tgaggatacc gctgtgtatt attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggcactaca gtgacagtgt cctcctgatg aattc          1555


<210>  67
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant 19

<400>  67
gacatccaga tgacccagtc tccatcctct ctgtctgctt ccctgggcga cagagccacc       60

atcacctgta gagcctccaa gaccgtgtcc acctcctcct actcctacat gcactggtat      120

cagcagaagc ccggccaggc tcctaagctg ctgattaagt acgcctccta cctggaatcc      180

ggcgtgccct ctagattctc cggctctggc tctggcaccg actttaccct gacaatctcc      240

agcctgcagc ctgaggactt cgccacctac tactgccagc actccagaga gttcccttgg      300

acctttggcc agggcaccaa ggtggaaatc aagagagctg acgctgctcc tggcggcgga      360

ggatctggcg gaggtggaag cggaggcggt ggatctgaag tgcagctggt tgagagtggt      420

ggcggattgg ttcagcctgg cggatctctg agactgtctt gtgccgcctc tggcttcacc      480

ttctccaact acggcatgca ttgggtccga caggcccctg gcaaaggact ggaatgggtg      540

tcctacatct cctccggctc ctccaccatc tactacgccg actctgtgaa gggcagattc      600

accatctctc gggacaacgc caagaactcc ctgtacctgc agatgaacag cctgagagcc      660

gaggacaccg ccgtgtacta ctgtgctaga agaggcctgc tgctggacta ttggggccag      720

ggaacaaccg tgaccgtgtc tagcgcttcc acaaagggcc cctctgtgtt ccctctggct      780

cctctggaat cttccggctc cgatattcag atgacacaga gcccttccag cctgtccgcc      840

tctctgggag atagagctac aatcacatgc cgggccagca agacagtgtc taccagcagc      900

tacagctata tgcattggta tcaacaaaaa cccgggcaag ccccaaagct cctgatcaaa      960

tacgccagct atctggaaag cggcgtgcca tctcggtttt ccggaagcgg ctctggaaca     1020

gactttacac tcaccattag ctccctccag ccagaggatt ttgctaccta ttattgccag     1080

catagccgcg agtttccatg gacattcgga cagggaacta aggtcgagat caagcgggcc     1140

gatgctgcac ctggcggagg cggttcaggt ggcggaggca gcggtggcgg cggtagtgaa     1200

gttcagttgg tcgagtcagg cggcggactt gttcaaccag gtggtagcct gagactgagc     1260

tgtgctgctt ccggctttac cttcagcaat tacggaatgc actgggttcg ccaagctcca     1320

ggcaaaggct tggagtgggt ttcatatatc tccagcggca gcagcaccat ctattatgct     1380

gacagcgtga aaggccggtt caccatcagc agagataatg ccaagaacag cctctacctc     1440

caaatgaact cactgcgcgc tgaggatacc gctgtgtatt attgcgcccg cagaggactc     1500

ctgctcgatt actggggaca gggcactaca gtgacagtgt cctcctgatg aattc          1555


<210>  68
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length heavy chain

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  69
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 constant heavy region 1

<400>  69

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 hinge region

<400>  70

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  71
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 L2345A/L235A constant heavy region 2

<400>  71

Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  72
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 constant heavy region 3

<400>  72

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  73
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 N297D heavy chain full length sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  74
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 N297D constant heavy region 2

<400>  74

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  75
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 L2345A/L235A/N297D heavy chain full length sequence

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  76
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 L2345A/L235A/N297D constant heavy region 2

<400>  76

Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  77
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unmodified constant heavy region 2

<400>  77

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  78
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain full length sequence

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Thr Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


