               SEQUENCE LISTING

<110> Fundación Instituto de Investigación Hospital 12 de Octubre
      Servicio Andaluz de Salud
      Consejo Superior de Investigaciones Científicas

<120> N-Cadherina y FGFR1 y/o FGFR4 para uso en la predicción de la respuesta de los pacientes a un tratamiento del cáncer de pulmón y método y kit basados en dicho uso

<130> PCT-07925

<150> ES201730929
<151> 2017-07-13

<160> 6

<170> BiSSAP 1.3.6

<210> 1
<211> 3873
<212> DNA
<213> Homo sapiens


<220> 
<223> Cadherina 2 (CDH2)

<400> 1
ctgctgccgc tgctggcggc cctgcttcag gcgtctgtag aggcttctgg tgaaatcgca       60

ttatgcaaga ctggatttcc tgaagatgtt tacagtgcag tcttatcgaa ggatgtgcat      120

gaaggacagc ctcttctcaa tgtgaagttt agcaactgca atggaaaaag aaaagtacaa      180

tatgagagca gtgagcctgc agattttaag gtggatgaag atggcatggt gtatgccgtg      240

agaagctttc cactctcttc tgagcatgcc aagttcctga tatatgccca agacaaagag      300

acccaggaaa agtggcaagt ggcagtaaaa ttgagcctga agccaacctt aactgaggag      360

tcagtgaagg agtcagcaga agttgaagaa atagtgttcc caagacaatt cagtaagcac      420

agtggccacc tacaaaggca gaagagagac tgggtcatcc ctccaatcaa cttgccagaa      480

aactccaggg gaccttttcc tcaagagctt gtcaggatca ggtctgatag agataaaaac      540

ctttcactgc ggtacagtgt aactgggcca ggagctgacc agcctccaac tggtatcttc      600

attatcaacc ccatctcggg tcagctgtcg gtgacaaagc ccctggatcg cgagcagata      660

gcccggtttc atttgagggc acatgcagta gatattaatg gaaatcaagt ggagaacccc      720

attgacattg tcatcaatgt tattgacatg aatgacaaca gacctgagtt cttacaccag      780

gtttggaatg ggacagttcc tgagggatca aagcctggaa catatgtgat gaccgtaaca      840

gcaattgatg ctgacgatcc caatgccctc aatgggatgt tgaggtacag aatcgtgtct      900

caggctccaa gcaccccttc acccaacatg tttacaatca acaatgagac tggtgacatc      960

atcacagtgg cagctggact tgatcgagaa aaagtgcaac agtatacgtt aataattcaa     1020

gctacagaca tggaaggcaa tcccacatat ggcctttcaa acacagccac ggccgtcatc     1080

acagtgacag atgtcaatga caatcctcca gagtttactg ccatgacgtt ttatggtgaa     1140

gttcctgaga acagggtaga catcatagta gctaatctaa ctgtgaccga taaggatcaa     1200

ccccatacac cagcctggaa cgcagtgtac agaatcagtg gcggagatcc tactggacgg     1260

ttcgccatcc agaccgaccc aaacagcaac gacgggttag tcaccgtggt caaaccaatc     1320

gactttgaaa caaataggat gtttgtcctt actgttgctg cagaaaatca agtgccatta     1380

gccaagggaa ttcagcaccc gcctcagtca actgcaaccg tgtctgttac agttattgac     1440

gtaaatgaaa acccttattt tgcccccaat cctaagatca ttcgccaaga agaagggctt     1500

catgccggta ccatgttgac aacattcact gctcaggacc cagatcgata tatgcagcaa     1560

aatattagat acactaaatt atctgatcct gccaattggc taaaaataga tcctgtgaat     1620

ggacaaataa ctacaattgc tgttttggac cgagaatcac caaatgtgaa aaacaatata     1680

tataatgcta ctttccttgc ttctgacaat ggaattcctc ctatgagtgg aacaggaacg     1740

ctgcagatct atttacttga tattaatgac aatgcccctc aagtgttacc tcaagaggca     1800

gagacttgcg aaactccaga ccccaattca attaatatta cagcacttga ttatgacatt     1860

gatccaaatg ctggaccatt tgcttttgat cttcctttat ctccagtgac tattaagaga     1920

aattggacca tcactcggct taatggtgat tttgctcagc ttaatttaaa gataaaattt     1980

cttgaagctg gtatctatga agttcccatc ataatcacag attcgggtaa tcctcccaaa     2040

tcaaatattt ccatcctgcg cgtgaaggtt tgccagtgtg actccaacgg ggactgcaca     2100

gatgtggaca ggattgtggg tgcggggctt ggcaccggtg ccatcattgc catcctgctc     2160

tgcatcatca tcctgcttat ccttgtgctg atgtttgtgg tatggatgaa acgccgggat     2220

aaagaacgcc aggccaaaca acttttaatt gatccagaag atgatgtaag agataatatt     2280

ttaaaatatg atgaagaagg tggaggagaa gaagaccagg actatgactt gagccagctg     2340

cagcagcctg acactgtgga gcctgatgcc atcaagcctg tgggaatccg acgaatggat     2400

gaaagaccca tccacgccga gccccagtat ccggtccgat ctgcagcccc acaccctgga     2460

gacattgggg acttcattaa tgagggcctt aaagcggctg acaatgaccc cacagctcca     2520

ccatatgact ccctgttagt gtttgactat gaaggcagtg gctccactgc tgggtccttg     2580

agctccctta attcctcaag tagtggtggt gagcaggact atgattacct gaacgactgg     2640

gggccacggt tcaagaaact tgctgacatg tatggtggag gtgatgactg aacttcaggg     2700

tgaacttggt ttttggacaa gtacaaacaa tttcaactga tattcccaaa aagcattcag     2760

aagctaggct ttaactttgt agtctactag cacagtgctt gctggaggct ttggcatagg     2820

ctgcaaacca atttgggctc agagggaata tcagtgatcc atactgtttg gaaaaacact     2880

gagctcagtt acacttgaat tttacagtac agaagcactg ggattttatg tgcctttttg     2940

tacctttttc agattggaat tagttttctg tttaaggctt taatggtact gatttctgaa     3000

acgataagta aaagacaaaa tattttgtgg tgggagcagt aagttaaacc atgatatgct     3060

tcaacacgct tttgttacat tgcatttgct tttattaaaa tacaaaatta aacaaacaaa     3120

aaaactcatg gagcgatttt attatcttgg gggatgagac catgagattg gaaaatgtac     3180

attacttcta gttttagact ttagtttgtt tttttttttt tcactaaaat cttaaaactt     3240

actcagctgg ttgcaaataa agggagtttt catatcacca atttgtagca aaattgaatt     3300

ttttcataaa ctagaatgtt agacacattt tggtcttaat ccatgtacac ttttttattt     3360

ctgtattttt ccacttcact gtaaaaatag tatgtgtaca taatgtttta ttggcatagt     3420

ctatggagaa gtgcagaaac ttcagaacat gtgtatgtat tatttggact atggattcag     3480

gttttttgca tgtttatatc tttcgttatg gataaagtat ttacaaaaca gtgacatttg     3540

attcaattgt tgagctgtag ttagaatact caatttttaa tttttttaat ttttttattt     3600

tttattttct ttttggtttg gggagggaga aaagttctta gcacaaatgt tttacataat     3660

ttgtaccaaa aaaaaaaaaa aaggaaagga aagaaagggg tggcctgaca ctggtggcac     3720

tactaagtgt gtgttttttt aaaaaaaaaa tggaaaaaaa aaagctttta aactggagag     3780

acttctgaca acagctttgc ctctgtattg tgtaccagaa tataaatgat acacctctga     3840

ccccagcgtt ctgaataaaa tgctaatttt gga                                  3873


<210> 2
<211> 2466
<212> DNA
<213> Homo sapiens


<220> 
<223> ORF del Receptor 1 del Factor de Crecimiento de Fibroblastos
      (FGFR1), variante 1.

<400> 2
atgtggagct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac actctgcacc      60

gctaggccgt ccccgacctt gcctgaacaa gcccagccct ggggagcccc tgtggaagtg     120

gagtccttcc tggtccaccc cggtgacctg ctgcagcttc gctgtcggct gcgggacgat     180

gtgcagagca tcaactggct gcgggacggg gtgcagctgg cggaaagcaa ccgcacccgc     240

atcacagggg aggaggtgga ggtgcaggac tccgtgcccg cagactccgg cctctatgct     300

tgcgtaacca gcagcccctc gggcagtgac accacctact tctccgtcaa tgtttcagat     360

gctctcccct cctcggagga tgatgatgat gatgatgact cctcttcaga ggagaaagaa     420

acagataaca ccaaaccaaa ccgtatgccc gtagctccat attggacatc cccagaaaag     480

atggaaaaga aattgcatgc agtgccggct gccaagacag tgaagttcaa atgcccttcc     540

agtgggaccc caaaccccac actgcgctgg ttgaaaaatg gcaaagaatt caaacctgac     600

cacagaattg gaggctacaa ggtccgttat gccacctgga gcatcataat ggactctgtg     660

gtgccctctg acaagggcaa ctacacctgc attgtggaga atgagtacgg cagcatcaac     720

cacacatacc agctggatgt cgtggagcgg tcccctcacc ggcccatcct gcaagcaggg     780

ttgcccgcca acaaaacagt ggccctgggt agcaacgtgg agttcatgtg taaggtgtac     840

agtgacccgc agccgcacat ccagtggcta aagcacatcg aggtgaatgg gagcaagatt     900

ggcccagaca acctgcctta tgtccagatc ttgaagactg ctggagttaa taccaccgac     960

aaagagatgg aggtgcttca cttaagaaat gtctcctttg aggacgcagg ggagtatacg    1020

tgcttggcgg gtaactctat cggactctcc catcactctg catggttgac cgttctggaa    1080

gccctggaag agaggccggc agtgatgacc tcgcccctgt acctggagat catcatctat    1140

tgcacagggg ccttcctcat ctcctgcatg gtggggtcgg tcatcgtcta caagatgaag    1200

agtggtacca agaagagtga cttccacagc cagatggctg tgcacaagct ggccaagagc    1260

atccctctgc gcagacaggt aacagtgtct gctgactcca gtgcatccat gaactctggg    1320

gttcttctgg ttcggccatc acggctctcc tccagtggga ctcccatgct agcaggggtc    1380

tctgagtatg agcttcccga agaccctcgc tgggagctgc ctcgggacag actggtctta    1440

ggcaaacccc tgggagaggg ctgctttggg caggtggtgt tggcagaggc tatcgggctg    1500

gacaaggaca aacccaaccg tgtgaccaaa gtggctgtga agatgttgaa gtcggacgca    1560

acagagaaag acttgtcaga cctgatctca gaaatggaga tgatgaagat gatcgggaag    1620

cataagaata tcatcaacct gctgggggcc tgcacgcagg atggtccctt gtatgtcatc    1680

gtggagtatg cctccaaggg caacctgcgg gagtacctgc aggcccggag gcccccaggg    1740

ctggaatact gctacaaccc cagccacaac ccagaggagc agctctcctc caaggacctg    1800

gtgtcctgcg cctaccaggt ggcccgaggc atggagtatc tggcctccaa gaagtgcata    1860

caccgagacc tggcagccag gaatgtcctg gtgacagagg acaatgtgat gaagatagca    1920

gactttggcc tcgcacggga cattcaccac atcgactact ataaaaagac aaccaacggc    1980

cgactgcctg tgaagtggat ggcacccgag gcattatttg accggatcta cacccaccag    2040

agtgatgtgt ggtctttcgg ggtgctcctg tgggagatct tcactctggg cggctcccca    2100

taccccggtg tgcctgtgga ggaacttttc aagctgctga aggagggtca ccgcatggac    2160

aagcccagta actgcaccaa cgagctgtac atgatgatgc gggactgctg gcatgcagtg    2220

ccctcacaga gacccacctt caagcagctg gtggaagacc tggaccgcat cgtggccttg    2280

acctccaacc aggagtacct ggacctgtcc atgcccctgg accagtactc ccccagcttt    2340

cccgacaccc ggagctctac gtgctcctca ggggaggatt ccgtcttctc tcatgagccg    2400

ctgcccgagg agccctgcct gccccgacac ccagcccagc ttgccaatgg cggactcaaa    2460

cgccgc                                                               2466


<210> 3
<211> 2406
<212> DNA
<213> Homo sapiens


<220> 
<223> ORF del Receptor 4 del Factor de crecimiento de fibroblastos
      (FGFR4), variante 1

<400> 3
atgcggctgc tgctggccct gttgggggtc ctgctgagtg tgcctgggcc tccagtcttg      60

tccctggagg cctctgagga agtggagctt gagccctgcc tggctcccag cctggagcag     120

caagagcagg agctgacagt agcccttggg cagcctgtgc gtctgtgctg tgggcgggct     180

gagcgtggtg gccactggta caaggagggc agtcgcctgg cacctgctgg ccgtgtacgg     240

ggctggaggg gccgcctaga gattgccagc ttcctacctg aggatgctgg ccgctacctc     300

tgcctggcac gaggctccat gatcgtcctg cagaatctca ccttgattac aggtgactcc     360

ttgacctcca gcaacgatga tgaggacccc aagtcccata gggacccctc gaataggcac     420

agttaccccc agcaagcacc ctactggaca cacccccagc gcatggagaa gaaactgcat     480

gcagtacctg cggggaacac cgtcaagttc cgctgtccag ctgcaggcaa ccccacgccc     540

accatccgct ggcttaagga tggacaggcc tttcatgggg agaaccgcat tggaggcatt     600

cggctgcgcc atcagcactg gagtctcgtg atggagagcg tggtgccctc ggaccgcggc     660

acatacacct gcctggtaga gaacgctgtg ggcagcatcc gctataacta cctgctagat     720

gtgctggagc ggtccccgca ccggcccatc ctgcaggccg ggctcccggc caacaccaca     780

gccgtggtgg gcagcgacgt ggagctgctg tgcaaggtgt acagcgatgc ccagccccac     840

atccagtggc tgaagcacat cgtcatcaac ggcagcagct tcggagccga cggtttcccc     900

tatgtgcaag tcctaaagac tgcagacatc aatagctcag aggtggaggt cctgtacctg     960

cggaacgtgt cagccgagga cgcaggcgag tacacctgcc tcgcaggcaa ttccatcggc    1020

ctctcctacc agtctgcctg gctcacggtg ctgccagagg aggaccccac atggaccgca    1080

gcagcgcccg aggccaggta tacggacatc atcctgtacg cgtcgggctc cctggccttg    1140

gctgtgctcc tgctgctggc cgggctgtat cgagggcagg cgctccacgg ccggcacccc    1200

cgcccgcccg ccactgtgca gaagctctcc cgcttccctc tggcccgaca gttctccctg    1260

gagtcaggct cttccggcaa gtcaagctca tccctggtac gaggcgtgcg tctctcctcc    1320

agcggccccg ccttgctcgc cggcctcgtg agtctagatc tacctctcga cccactatgg    1380

gagttccccc gggacaggct ggtgcttggg aagcccctag gcgagggctg ctttggccag    1440

gtagtacgtg cagaggcctt tggcatggac cctgcccggc ctgaccaagc cagcactgtg    1500

gccgtcaaga tgctcaaaga caacgcctct gacaaggacc tggccgacct ggtctcggag    1560

atggaggtga tgaagctgat cggccgacac aagaacatca tcaacctgct tggtgtctgc    1620

acccaggaag ggcccctgta cgtgatcgtg gagtgcgccg ccaagggaaa cctgcgggag    1680

ttcctgcggg cccggcgccc cccaggcccc gacctcagcc ccgacggtcc tcggagcagt    1740

gaggggccgc tctccttccc agtcctggtc tcctgcgcct accaggtggc ccgaggcatg    1800

cagtatctgg agtcccggaa gtgtatccac cgggacctgg ctgcccgcaa tgtgctggtg    1860

actgaggaca atgtgatgaa gattgctgac tttgggctgg cccgcggcgt ccaccacatt    1920

gactactata agaaaaccag caacggccgc ctgcctgtga agtggatggc gcccgaggcc    1980

ttgtttgacc gggtgtacac acaccagagt gacgtgtggt cttttgggat cctgctatgg    2040

gagatcttca ccctcggggg ctccccgtat cctggcatcc cggtggagga gctgttctcg    2100

ctgctgcggg agggacatcg gatggaccga cccccacact gccccccaga gctgtacggg    2160

ctgatgcgtg agtgctggca cgcagcgccc tcccagaggc ctaccttcaa gcagctggtg    2220

gaggcgctgg acaaggtcct gctggccgtc tctgaggagt acctcgacct ccgcctgacc    2280

ttcggaccct attccccctc tggtggggac gccagcagca cctgctcctc cagcgattct    2340

gtcttcagcc acgaccccct gccattggga tccagctcct tccccttcgg gtctggggtg    2400

cagaca                                                               2406


<210> 4
<211> 906
<212> PRT
<213> Homo sapiens


<220> 
<223> N-cadherina (NCBI: NP_001783.2)

<400> 4
Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     

<210> 5
<211> 822
<212> PRT
<213> Homo sapiens


<220> 
<223> Receptor 1 del Factor de crecimiento de fibroblastos (FGFR1).
      NCBI: NP_075598.2

<400> 5
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             
Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 
Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     
Gly Gly Leu Lys Arg Arg 
            820         

<210> 6
<211> 802
<212> PRT
<213> Homo sapiens


<220> 
<223> Receptor 4 del Factor de crecimiento de fibroblastos (FGFR4).
      NCBI: NP_002002.3

<400> 6
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 
Gln Thr 
        

