                         SEQUENCE LISTING

<110>  Phenex-FXR GmbH
 
<120>  Amine or (thio)amide containing LXR modulators

<130>  PCT113741KG030

<140>  not yet assigned
<141>  herewith

<150>  EP17001230.6
<151>  2017-07-18

<160>  19     

<170>  PatentIn version 3.5

<210>  1
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-Sequence LXR alpha-full length

<400>  1
atgtccttgt ggctgggggc ccctgtgcct gacattcctc ctgactctgc ggtggagctg       60

tggaagccag gcgcacagga tgcaagcagc caggcccagg gaggcagcag ctgcatcctc      120

agagaggaag ccaggatgcc ccactctgct gggggtactg caggggtggg gctggaggct      180

gcagagccca cagccctgct caccagggca gagccccctt cagaacccac agagatccgt      240

ccacaaaagc ggaaaaaggg gccagccccc aaaatgctgg ggaacgagct atgcagtgtg      300

tgtggggaca aggcctcggg cttccactac aatgttctga gctgcgaggg ctgcaaggga      360

ttcttccgcc gcagcgtcat caagggagcg cactacatct gccacagtgg cggccactgc      420

cccatggaca cctacatgcg tcgcaagtgc caggagtgtc ggcttcgcaa atgccgtcag      480

gctggcatgc gggaggagtg tgtcctgtca gaagaacaga tccgcctgaa gaaactgaag      540

cggcaagagg aggaacaggc tcatgccaca tccttgcccc ccagggcttc ctcacccccc      600

caaatcctgc cccagctcag cccggaacaa ctgggcatga tcgagaagct cgtcgctgcc      660

cagcaacagt gtaaccggcg ctccttttct gaccggcttc gagtcacgcc ttggcccatg      720

gcaccagatc cccatagccg ggaggcccgt cagcagcgct ttgcccactt cactgagctg      780

gccatcgtct ctgtgcagga gatagttgac tttgctaaac agctacccgg cttcctgcag      840

ctcagccggg aggaccagat tgccctgctg aagacctctg cgatcgaggt gatgcttctg      900

gagacatctc ggaggtacaa ccctgggagt gagagtatca ccttcctcaa ggatttcagt      960

tataaccggg aagactttgc caaagcaggg ctgcaagtgg aattcatcaa ccccatcttc     1020

gagttctcca gggccatgaa tgagctgcaa ctcaatgatg ccgagtttgc cttgctcatt     1080

gctatcagca tcttctctgc agaccggccc aacgtgcagg accagctcca ggtagagagg     1140

ctgcagcaca catatgtgga agccctgcat gcctacgtct ccatccacca tccccatgac     1200

cgactgatgt tcccacggat gctaatgaaa ctggtgagcc tccggaccct gagcagcgtc     1260

cactcagagc aagtgtttgc actgcgtctg caggacaaaa agctcccacc gctgctctct     1320

gagatctggg atgtgcacga atga                                            1344


<210>  2
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-Sequence LXR beta-full length

<400>  2
atgtcctctc ctaccacgag ttccctggat acccccctgc ctggaaatgg cccccctcag       60

cctggcgccc cttcttcttc acccactgta aaggaggagg gtccggagcc gtggcccggg      120

ggtccggacc ctgatgtccc aggcactgat gaggccagct cagcctgcag cacagactgg      180

gtcatcccag atcccgaaga ggaaccagag cgcaagcgaa agaagggccc agccccgaag      240

atgctgggcc acgagctttg ccgtgtctgt ggggacaagg cctccggctt ccactacaac      300

gtgctcagct gcgaaggctg caagggcttc ttccggcgca gtgtggtccg tggtggggcc      360

aggcgctatg cctgccgggg tggcggaacc tgccagatgg acgctttcat gcggcgcaag      420

tgccagcagt gccggctgcg caagtgcaag gaggcaggga tgagggagca gtgcgtcctt      480

tctgaagaac agatccggaa gaagaagatt cggaaacaac agcagcagga gtcacagtca      540

cagtcgcagt cacctgtggg gccgcagggc agcagcagct cagcctctgg gcctggggct      600

tcccctggtg gatctgaggc aggcagccag ggctccgggg aaggcgaggg cgtccagcta      660

acagcggctc aagaactaat gatccagcag ttggtggcgg cccaactgca gtgcaacaaa      720

cgctccttct ccgaccagcc caaagtcacg ccctggcccc tgggcgcaga cccccagtcc      780

cgagatgccc gccagcaacg ctttgcccac ttcacggagc tggccatcat ctcagtccag      840

gagatcgtgg acttcgctaa gcaagtgcct ggtttcctgc agctgggccg ggaggaccag      900

atcgccctcc tgaaggcatc cactatcgag atcatgctgc tagagacagc caggcgctac      960

aaccacgaga cagagtgtat caccttcttg aaggacttca cctacagcaa ggacgacttc     1020

caccgtgcag gcctgcaggt ggagttcatc aaccccatct tcgagttctc gcgggccatg     1080

cggcggctgg gcctggacga cgctgagtac gccctgctca tcgccatcaa catcttctcg     1140

gccgaccggc ccaacgtgca ggagccgggc cgcgtggagg cgttgcagca gccctacgtg     1200

gaggcgctgc tgtcctacac gcgcatcaag aggccgcagg accagctgcg cttcccgcgc     1260

atgctcatga agctggtgag cctgcgcacg ctgagctctg tgcactcgga gcaggtcttc     1320

gccttgcggc tccaggacaa gaagctgccg cctctgctgt cggagatctg ggacgtccac     1380

gagtga                                                                1386


<210>  3
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-Sequence LXR alpha-LBD

<400>  3
cttcgcaaat gccgtcaggc tggcatgcgg gaggagtgtg tcctgtcaga agaacagatc       60

cgcctgaaga aactgaagcg gcaagaggag gaacaggctc atgccacatc cttgcccccc      120

agggcttcct caccccccca aatcctgccc cagctcagcc cggaacaact gggcatgatc      180

gagaagctcg tcgctgccca gcaacagtgt aaccggcgct ccttttctga ccggcttcga      240

gtcacgcctt ggcccatggc accagatccc catagccggg aggcccgtca gcagcgcttt      300

gcccacttca ctgagctggc catcgtctct gtgcaggaga tagttgactt tgctaaacag      360

ctacccggct tcctgcagct cagccgggag gaccagattg ccctgctgaa gacctctgcg      420

atcgaggtga tgcttctgga gacatctcgg aggtacaacc ctgggagtga gagtatcacc      480

ttcctcaagg atttcagtta taaccgggaa gactttgcca aagcagggct gcaagtggaa      540

ttcatcaacc ccatcttcga gttctccagg gccatgaatg agctgcaact caatgatgcc      600

gagtttgcct tgctcattgc tatcagcatc ttctctgcag accggcccaa cgtgcaggac      660

cagctccagg tagagaggct gcagcacaca tatgtggaag ccctgcatgc ctacgtctcc      720

atccaccatc cccatgaccg actgatgttc ccacggatgc taatgaaact ggtgagcctc      780

cggaccctga gcagcgtcca ctcagagcaa gtgtttgcac tgcgtctgca ggacaaaaag      840

ctcccaccgc tgctctctga gatctgggat gtgcacgaat ga                         882


<210>  4
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-sequence LXR beta-LBD

<400>  4
gagcagtgcg tcctttctga agaacagatc cggaagaaga agattcggaa acaacagcag       60

caggagtcac agtcacagtc gcagtcacct gtggggccgc agggcagcag cagctcagcc      120

tctgggcctg gggcttcccc tggtggatct gaggcaggca gccagggctc cggggaaggc      180

gagggtgtcc agctaacagc ggctcaagaa ctaatgatcc agcagttggt ggcggcccaa      240

ctgcagtgca acaaacgctc cttctccgac cagcccaaag tcacgccctg gcccctgggc      300

gcagaccccc agtcccgaga tgcccgccag caacgctttg cccacttcac ggagctggcc      360

atcatctcag tccaggagat cgtggacttc gctaagcaag tgcctggttt cctgcagctg      420

ggccgggagg accagatcgc cctcctgaag gcatccacta tcgagatcat gctgctagag      480

acagccaggc gctacaacca cgagacagag tgtatcacct tcttgaagga cttcacctac      540

agcaaggacg acttccaccg tgcaggcctg caggtggagt tcatcaaccc catcttcgag      600

ttctcgcggg ccatgcggcg gctgggcctg gacgacgctg agtacgccct gctcatcgcc      660

atcaacatct tctcggccga ccggcccaac gtgcaggagc cgggccgcgt ggaggcgttg      720

cagcagccct acgtggaggc gctgctgtcc tacacgcgca tcaagaggcc gcaggaccag      780

ctgcgcttcc cgcgcatgct catgaagctg gtgagcctgc gcacgctgag ctctgtgcac      840

tcggagcagg tcttcgcctt gcggctccag gacaagaagc tgccgcctct gctgtcggag      900

atctgggacg tccacgagtg aggggctggc cacccagccc cacagccttg cctgaccacc      960

ctccagcaga tagacgccgg caccccttcc tcttcctctg cttttattta a              1011


<210>  5
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-sequence SRC1-fragment

<400>  5
gttggcttct ctgccagttc tccagtcctc aggcagatga gctcacagaa ttcacctagc       60

agattaaata tacaaccagc aaaagctgag tccaaagata acaaagagat tgcctcaatt      120

ttaaatgaaa tgattcaatc tgacaacagc tctagtgatg gcaaacctct ggattcaggg      180

cttctgcata acaatgacag actttcagat ggagacagta aatactctca aaccagtcac      240

aaactagtgc agcttttgac aacaactgcc gaacagcagt tacggcatgc tgatatagac      300

acaagctgca aagatgtcct gtcttgcaca ggcacttcca actctgcctc tgctaactct      360

tcaggaggtt cttgtccctc ttctcatagc tcattgacag aacggcataa aattctacac      420

cggctcttac aggagggtag cccctcagat atcaccactt tgtctgtcga gcctgataaa      480

aaggacagtg catctacttc tgtgtcagtg actggacagg tacaaggaaa ctccagtata      540

aaactagaac tggatgcttc aaagaaaaaa gaatcaaaag accatcagct cctacgctat      600

cttttagata aagatgagaa agatttaaga tcaactccaa acctgagcct ggatgatgta      660

aaggtgaaag tggaaaagaa agaacagatg gatccatgta atacaaaccc aaccccaatg      720

accaaaccca ctcctgagga aataaaactg gaggcccaga gccagtttac agctgacctt      780

gaccagtttg atcagttact gcccacgctg gagaaggcag cacagttgcc aggcttatgt      840

gagacagaca ggatggatgg tgcggtcacc agtgtaacca tcaaatcgga gatcctgcca      900

gcttcacttc agtccgccac tgccagaccc acttccaggc taaatagatt acctgagctg      960

gaattggaag caattgataa ccaatttgga caaccaggaa caggcgatta g              1011


<210>  6
<211>  1225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA-sequence NCoR-fragment

<400>  6
gataaagggc ctcctccaaa atccagatat gaggaagagc taaggaccag agggaagact       60

accattactg cagctaactt catagacgtg atcatcaccc ggcaaattgc ctcggacaag      120

gatgcgaggg aacgtggctc tcaaagttca gactcttcta gtagcttatc ttctcacagg      180

tatgaaacac ctagcgatgc tattgaggtg ataagtcctg ccagctcacc tgcgccaccc      240

caggagaaac tgcagaccta tcagccagag gttgttaagg caaatcaagc ggaaaatgat      300

cctaccagac aatatgaagg accattacat cactatcgac cacagcagga atcaccatct      360

ccccaacaac agctgccccc ttcttcacag gcagagggaa tggggcaagt gcccaggacc      420

catcggctga tcacacttgc tgatcacatc tgtcaaatta tcacacaaga ttttgctaga      480

aatcaagttt cctcgcagac tccccagcag cctcctactt ctacattcca gaactcacct      540

tctgctttgg tatctacacc tgtgaggact aaaacatcaa accgttacag cccagaatcc      600

caggctcagt ctgtccatca tcaaagacca ggttcaaggg tctctacaga aaatcttgtg      660

gacaaatcca ggggaagtag gcctggaaaa tccccagaga ggagtcacgt ctcttcggag      720

ccctacgagc ccatctcccc accccaggtt ccggttgtgc atgagaaaca ggacagcttg      780

ctgctcttgt ctcagagggg cgcagagcct gcagagcaga ggaatgatgc ccgctcacca      840

gggagtataa gctacttgcc ttcattcttc accaagcttg aaaatacatc acccatggtt      900

aaatcaaaga agcaggagat ttttcgtaag ttgaactcct ctggtggagg tgactctgat      960

atggcagctg ctcagccagg aactgagatc tttaatctgc cagcagttac tacgtcaggc     1020

tcagttagct ctagaggcca ttcttttgct gatcctgcca gtaatcttgg gctggaagac     1080

attatcagga aggctctcat gggaagcttt gatgacaaag ttgaggatca tggagttgtc     1140

atgtcccagc ctatgggagt agtgcctggt actgccaaca cctcagttgt gaccagtggt     1200

gagacacgaa gagaggaagg ggtga                                           1225


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  7

Glu Asn Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu 
1               5                   10                  15      


Gln Leu Leu Thr Cys Ser Ser Asp Asp 
            20                  25  

<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  8
cccctctgtt aattggctcc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  9
ttgtggaagt gcaggttagg                                                   20


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence probe

<400>  10
caggctcagg gtgtcccatg tt                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  11
ctgacctgaa agccgagaag                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  12
agaaggtgct aacgaacagg                                                   20


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence probe

<400>  13
tgtttacaaa agtctcgccc cagca                                             25


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  14
ccatcgacta catccgcttc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  15
gccctccata gacacatctg                                                   20


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence probe

<400>  16
tctcctgctt gagcttctgg ttgc                                              24


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  17
caccaatgac tcctatgacc c                                                 21


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  18
caagtttaca gccaagattc acg                                               23


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence probe

<400>  19
actcctgcca caccagcctc                                                   20


