                         SEQUENCE LISTING

<110>  H.Lundbeck A/S
 
<120>  Sortilin E-doamin antibodies

<130>  1079-DK-NP

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6003-028 HC CDR 1

<400>  1

Tyr Ala Met Ser 
1               


<210>  2
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  6003-028 HC CDR2

<400>  2

Thr Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-028 HC CDR3

<400>  3

Asn Leu Tyr Ser Asn Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-028 LC CDR1

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-028 LC CDR2

<400>  5

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-028 LC CDR3

<400>  6

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 HC CDR1

<400>  7

Ser Tyr Ala Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 HC CDR2

<400>  8

Ala Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 HC CDR3

<400>  9

Ile Ile Pro Ser Leu Tyr Trp Tyr Phe Asp 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 LC CDR1

<400>  10

Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 LC CDR2

<400>  11

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-056 LC CDR3

<400>  12

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 HC CDR1

<400>  13

Ser Tyr Ala Met Ser 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 HC CDR2

<400>  14

Thr Ile Ser Gly Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 HC CDR3

<400>  15

Asn Ile Tyr Ser His Tyr Trp Tyr Phe Asp 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 LC CDR1

<400>  16

Arg Ala Ser Gln Ser Val Asn Ser Tyr Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 LC CDR2

<400>  17

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  18
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 LC CDR3

<400>  18

Gln Gln Arg Ser Asn Trp Pro Leu Thr Phe 
1               5                   10  


<210>  19
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 HC CDR1

<400>  19

Ser Tyr Ala Met Ser 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 HC CDR2

<400>  20

Thr Ile Ser Gly Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 HC CDR3

<400>  21

Ile Ile Pro Ser Leu Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 LC CDR1

<400>  22

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 LC CDR2

<400>  23

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-030 LC CDR3

<400>  24

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 HC CDR1

<400>  25

His Tyr Gly Ile Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 HC CDR2

<400>  26

Trp Ile Asn Thr Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 HC CDR3

<400>  27

Leu Gly Arg Asn Phe Asp Tyr 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 LC CDR1

<400>  28

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 LC CDR2

<400>  29

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 LC CDR3

<400>  30

Gln Gln Arg Ser Asn Trp Pro Ala Leu Thr 
1               5                   10  


<210>  31
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 HC CDR1

<400>  31

Asn Tyr Val Met His 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 HC CDR2

<400>  32

Ala Ile Ser Tyr Asn Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 HC CDR3

<400>  33

Gly Leu Asn Asp Ala Phe Asp Ile 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 LC CDR1

<400>  34

Ala Ser Gln Ser Val Ser Gly Tyr Leu Ala 
1               5                   10  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 LC CDR2

<400>  35

Asn Ala Ser Asn Arg Ala Thr 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 LC CDR3

<400>  36

Gln Gln Arg Ser Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210>  37
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 HC CDR1

<400>  37

Ser Tyr Ala Met Ser 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 HC CDR2

<400>  38

Thr Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 HC CDR3

<400>  39

Ile Val Ala Thr Met Tyr Trp Tyr Phe Asp 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 LC CDR1

<400>  40

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 LC CDR2

<400>  41

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 LC CDR3

<400>  42

Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 HC CDR1

<400>  43

Ser Tyr Gly Met His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 HC CDR2

<400>  44

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 HC CDR3

<400>  45

Leu Thr Gly Asp Ala Phe Asp Ile 
1               5               


<210>  46
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 LC CDR1

<400>  46

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Val 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 LC CDR2

<400>  47

His Ala Ser Asn Arg Ala Thr 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 LC CDR3

<400>  48

Gln Gln Arg Ser Asn Trp Pro Arg Ile Thr 
1               5                   10  


<210>  49
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 HC CDR1

<400>  49

Ser Tyr Ala Met Ser 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 HC CDR2

<400>  50

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 HC CDR3

<400>  51

Asp Ile Arg Gly Ile Gly Phe Gly Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  


<210>  52
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 LC CDR1

<400>  52

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Val 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 LC CDR2

<400>  53

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 LC CDR3

<400>  54

Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6002-423 HC CDR1

<400>  55

Ser Tyr Val Met Ser 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 HC CDR2

<400>  56

Thr Ile Ser Gly Gly Gly Gly Asn Thr Asn Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 HC CDR3

<400>  57

Asn Trp Gly Ser Gly Phe Asp Tyr 
1               5               


<210>  58
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 LC CDR1

<400>  58

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 LC CDR2

<400>  59

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  60
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 LC CDR3

<400>  60

Gln Gln Arg Ser Asn Trp Leu Ile Phe Thr 
1               5                   10  


<210>  61
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 HC CDR1

<400>  61

Ser Tyr Ala Met Ser 
1               5   


<210>  62
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 HC CDR2

<400>  62

Ser Ile Ser Gly Arg Leu Gly Thr Thr Tyr Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 HC CDR3

<400>  63

Lys Ala Pro Ser Asp Ala Phe Asp Ile 
1               5                   


<210>  64
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 LC CDR1

<400>  64

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 LC CDR2

<400>  65

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  66
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 LC CDR3

<400>  66

Gln Gln Arg Ser Asn Trp Pro Ile Phe Thr 
1               5                   10  


<210>  67
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 HC CDR1

<400>  67

Lys Tyr Gly Ile Ser 
1               5   


<210>  68
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 HC CDR2

<400>  68

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Asp 
    


<210>  69
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 HC CDR3

<400>  69

Asp Gly Pro Leu Thr Gly Asp Phe Thr Phe Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  70
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 LC CDR1

<400>  70

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  71
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 LC CDR2

<400>  71

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  72
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 LC CDR3

<400>  72

Gln Gln Arg Ser Asn Trp Pro Pro Phe Thr 
1               5                   10  


<210>  73
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 HC CDR1

<400>  73

Ser Tyr Ala Met Asn 
1               5   


<210>  74
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 HC CDR2

<400>  74

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 HC CDR3

<400>  75

Arg Gly Arg Gly Ile Gly Tyr Tyr Asn Gly Met Asp Val 
1               5                   10              


<210>  76
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 LC CDR1

<400>  76

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  77
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 LC CDR2

<400>  77

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  78
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 LC CDR3

<400>  78

Gln Gln Tyr Gly Ser Ser Pro Met Tyr Thr 
1               5                   10  


<210>  79
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 HC CDR1

<400>  79

Ser Tyr Ser Met Asn 
1               5   


<210>  80
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 HC CDR2

<400>  80

Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  81
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 HC CDR3

<400>  81

Arg Gly Ser Gly Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 LC CDR1

<400>  82

Arg Ala Ser Gln Ser Ile Gly Tyr Ser Leu His 
1               5                   10      


<210>  83
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 LC CDR2

<400>  83

Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 LC CDR3

<400>  84

His Gln Ser Ser Ser Leu Pro Leu Thr 
1               5                   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 HC CDR1

<400>  85

Ser Phe Trp Ile Gly 
1               5   


<210>  86
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 HC CDR2

<400>  86

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


<210>  87
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 HC CDR3

<400>  87

His Ser Arg Gly Ser Phe Trp Tyr Gly Ala Phe Gln His 
1               5                   10              


<210>  88
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 LC CDR1

<400>  88

Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210>  89
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 LC CDR2

<400>  89

Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210>  90
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 LC CDR3

<400>  90

His Gln Ser Ser Ser Leu Pro His Thr 
1               5                   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 HC CDR1

<400>  91

Ser Tyr Ser Met Asn 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 HC CDR2

<400>  92

Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 HC CDR3

<400>  93

Arg Arg Ile Ala Ala Ala Gly Thr Gly Tyr Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  94
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 LC CDR1

<400>  94

Arg Ala Ser Gln Gly Ile Thr Ser Ala Leu Ala 
1               5                   10      


<210>  95
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 LC CDR2

<400>  95

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  96
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 LC CDR3

<400>  96

Gln Gln Phe Asn Gly Tyr Pro Met Phe Ser 
1               5                   10  


<210>  97
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 HC CDR1

<400>  97

Asn Tyr Ala Ile Ser 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 HC CDR2

<400>  98

Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 HC CDR3

<400>  99

Asp Arg Arg Gly Phe Ser Gly Tyr Glu Val Phe Asp Tyr 
1               5                   10              


<210>  100
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 LC CDR1

<400>  100

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  101
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 LC CDR2

<400>  101

Ala Thr Ser Ser Leu Gln Ser 
1               5           


<210>  102
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 LC CDR3

<400>  102

Gln Gln Tyr Asn Ser Tyr Pro Ile Thr Phe 
1               5                   10  


<210>  103
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 HC CDR1

<400>  103

Asp Tyr Ala Met His 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 HC CDR2

<400>  104

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 HC CDR3

<400>  105

Asp Pro Ser Gly Gly Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 LC CDR1

<400>  106

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 LC CDR2

<400>  107

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  108
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 LC CDR3

<400>  108

Gln Gln Arg Ser His Trp Pro Arg Thr 
1               5                   


<210>  109
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-28 HC

<400>  109

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Leu Tyr Ser Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  110
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-28 LC

<400>  110

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-56 HC

<400>  111

Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Pro Ser Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  112
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-56 LC

<400>  112

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  113
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 HC

<400>  113

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Ile Tyr Ser His Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  114
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1286 LC

<400>  114

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  115
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-30 HC

<400>  115

Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Arg Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Pro Ser Leu Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  116
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-30 LC

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  117
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 HC

<400>  117

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr His Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gly Arg Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  118
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-1277 LC

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ala 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  119
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 HC

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asn Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Ser Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  120
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-381 LC

<400>  120

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  121
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 HC

<400>  121

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ala Thr Met Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-83 LC

<400>  122

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 HC

<400>  123

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Thr Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  124
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-799 LC

<400>  124

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  125
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 HC

<400>  125

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Arg Gly Ile Gly Phe Gly Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  126
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-910 LC

<400>  126

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  127
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 HC

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Gly Asn Thr Asn Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Trp Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  128
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-423 LC

<400>  128

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Leu Ile 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  129
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 HC

<400>  129

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Arg Leu Gly Thr Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Ser Cys 
                85                  90                  95      


Ala Lys Ala Pro Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  130
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-822 LC

<400>  130

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  131
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 HC

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Thr Phe Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Pro Leu Thr Gly Asp Phe Thr Phe Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  132
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-886 LC

<400>  132

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  133
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 HC

<400>  133

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Arg Gly Ile Gly Tyr Tyr Asn Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  134
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  6003-72 LC

<400>  134

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  135
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 HC

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ser Gly Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  136
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-900 LC

<400>  136

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Tyr Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  137
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 HC

<400>  137

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Ser Phe 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Arg Gly Ser Phe Trp Tyr Gly Ala Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  138
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-936 LC

<400>  138

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  139
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 HC

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Ile Ala Ala Ala Gly Thr Gly Tyr Gly Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  140
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  6003-408 LC

<400>  140

Ala Arg Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Gly Tyr Pro Met 
                85                  90                  95      


Phe Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Ile 
            100                 105             


<210>  141
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 HC

<400>  141

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Phe Ser Gly Tyr Glu Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  142
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-471 LC

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  143
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 HC

<400>  143

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Val Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Gly Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  144
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  6003-972 LC

<400>  144

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Arg Ser His Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  145
<211>  831
<212>  PRT
<213>  Artificial

<220>
<223>  Human Sortilin Isofrom 1

<400>  145

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  146
<211>  145
<212>  PRT
<213>  Artificial

<220>
<223>  E- Region

<400>  146

Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp Pro 
1               5                   10                  15      


Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu 
            20                  25                  30          


Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val Val 
        35                  40                  45              


Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu Cys 
    50                  55                  60                  


Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu Gln 
65                  70                  75                  80  


Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg Glu 
                85                  90                  95      


Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys Cys 
            100                 105                 110         


Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys Lys 
        115                 120                 125             


Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser Lys Ser Asn 
    130                 135                 140                 


Ser 
145 


<210>  147
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin "hSORTECDBAP"

<400>  147

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu 
        195                 200                 205             


Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln 
                245                 250                 255     


Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp 
    290                 295                 300                 


Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile 
            340                 345                 350         


Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn 
        355                 360                 365             


Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr 
        435                 440                 445             


Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser 
    450                 455                 460                 


Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr 
            500                 505                 510         


Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  148
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin SORTECDBAP_hBACK

<400>  148

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Ile Phe Asn Asp Leu Ser 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe Gln Val Pro Ile Phe Met Ile Thr Ile Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Ser Asp Phe Gly Ile Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Asp Val Ser 
            100                 105                 110         


Gly Ser His Gly Ser Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn 
        115                 120                 125             


Phe Val Gln Gln Glu Leu Pro Phe Val Pro Leu Met Gln Ile Met Tyr 
    130                 135                 140                 


Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Asn Lys Asn Glu 
145                 150                 155                 160 


Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Lys Leu Tyr Asp 
                165                 170                 175     


Thr Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr 
            180                 185                 190         


Ala Asn His Asn Gly Ser Cys Ser Asn Asp Arg Gly Met Leu Glu Leu 
        195                 200                 205             


Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Ser Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Thr Gly Lys Gly Thr Leu Arg Ala Ile His Val Ser Thr Asp Gln Gly 
                245                 250                 255     


Asp Thr Trp Ser Met Ala Gln Leu Pro Pro Val Gly His Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Ser Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Glu Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr 
                325                 330                 335     


Ile Thr Ser Ile Leu Ala Glu Asp Lys Ser Val Gln Ser Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Lys Cys Asp Ala Thr Ala Arg Asp Pro Glu Lys Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ala Tyr Ser Ile Ala Thr Gly Leu Asn Val Pro Met Leu Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Arg Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Ala Leu Glu Gly Pro His His Tyr Thr 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Val Glu Gln Asn Ala His 
    450                 455                 460                 


Gln Gly Val Asn Gln Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Asn Phe Thr Lys Asp Pro Ile Phe Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Tyr Arg 
            500                 505                 510         


Ser Ser Leu Phe His Gln Tyr Trp Ile Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  149
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_tetra

<400>  149

Arg Ser Thr Glu Gln Gly Glu Ser Cys Ser Gly Leu Leu Gly Ala Asp 
1               5                   10                  15      


Ala Lys Leu Ala Gly Asn Thr His Gln His Ile Phe Asn Asp Leu Ser 
            20                  25                  30          


Gly Ser Val Ser Leu Ala Trp Val Gly Asp Gly Thr Gly Val Ile Leu 
        35                  40                  45              


Ala Leu Thr Thr Phe Gln Val Pro Ile Phe Met Ile Thr Ile Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Ser Phe Glu Asp Val 
65                  70                  75                  80  


Thr Asn Leu Ile Asn Asn Thr Phe Ile Arg Ser Asp Phe Gly Ile Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Ile Leu Thr Ala Asp Val Ser 
            100                 105                 110         


Gly Ser His Gly Ser Arg Ile Phe Val Ser Ser Asp Phe Gly Lys Ser 
        115                 120                 125             


Phe Thr His Gln Glu Leu Pro Phe Val Pro Leu Met Gln Ile Thr Tyr 
    130                 135                 140                 


Asn Pro Glu Asn Ser Asn Val Leu Leu Ala Leu Ser Asn Lys Asn Glu 
145                 150                 155                 160 


Leu Trp Leu Ser Glu Asp Phe Gly Thr Asn Trp Lys Lys Leu Tyr Asp 
                165                 170                 175     


Thr Val Cys Leu Ala Lys Trp Gly Arg Lys Gly Thr Ile Phe Phe Thr 
            180                 185                 190         


Ala Asn His Asn Gly Ser Cys Ser Asn Asp Arg Gly Met Leu Glu Leu 
        195                 200                 205             


Glu Arg Thr Thr Asp Tyr Gly Lys Ser Phe Lys Thr Val Ala Ser Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Lys Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Thr Gly Lys Gly Thr Leu Arg Ala Ile His Val Ser Val Asp Asp Gly 
                245                 250                 255     


Asp Thr Trp Asn Met Ala Gln Leu Pro Pro Val Gly His Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Glu Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Ser Gly Phe Gly Thr Ile Tyr Val Ser Asp Asp Arg 
    290                 295                 300                 


Gly Thr Val Tyr Ser Lys Ser Leu Glu Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Ile Asn Val Thr Ser Leu Arg Gly Val Phe 
                325                 330                 335     


Thr Thr Ser Ile Leu Ala Glu Asp Lys Ser Val Gln Ser Val Ile Ser 
            340                 345                 350         


Phe Asp Gln Gly Gly Glu Trp Val Pro Leu Arg Lys Pro Ala Asp Ser 
        355                 360                 365             


Lys Cys Asp Ala Thr Ala Arg Asp Pro Glu Lys Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ala Tyr Ser Ile Ala Thr Gly Leu Asn Val Pro Met Leu Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Leu Val Leu Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Arg Pro Asp Val Tyr Val Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Thr Trp Ile Lys Ala Leu Glu Gly Pro His His Tyr Ala 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Leu Leu Val Ala Val Glu Gln Asn Ala His 
    450                 455                 460                 


Gln Gly Val Asn Gln Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gly Val Tyr Asn Phe Thr Lys Asp Pro Ile Phe Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Val Ser Leu Trp Gly Tyr Arg 
            500                 505                 510         


Ser Ser Leu Phe His Gln Tyr Trp Ile Ser Phe Thr Ile Asp Phe Arg 
        515                 520                 525             


Asp Leu Ile Thr Arg Asn Cys Thr Asp Lys Asp Tyr Val Gln Trp Leu 
    530                 535                 540                 


Ala His Ser Asp Asp Ile Ser Asp Pro Asn Asp Gly Cys Met Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Lys Phe Leu Arg Leu Lys Lys Asp Ser Val Cys Leu Asn 
                565                 570                 575     


Gly Arg Asp Tyr Glu Val Asn Thr Gln Pro Thr Pro Cys Leu Cys Thr 
            580                 585                 590         


Leu Asp Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Lys Glu Asn Ser 
        595                 600                 605             


Ser Glu Cys Val Glu Gln Pro Asp Leu Lys Gly Lys Val Leu Glu Phe 
    610                 615                 620                 


Cys Leu His Gly Thr Glu Glu Glu Leu Leu Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Glu Gly Gly Gln Ile Pro Glu Arg Lys Glu 
                645                 650                 655     


Ile Asn Leu Arg Arg Arg Cys Val Ser Asp Leu Leu Gly Pro Glu Phe 
            660                 665                 670         


Leu Val Lys Lys Ser Ser Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  150
<211>  701
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_hB01-05

<400>  150

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu 
        195                 200                 205             


Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln 
                245                 250                 255     


Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Pro Val Gly His Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Glu Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Ser Gly Phe Gly Thr Ile Tyr Val Ser Asp Asp 
    290                 295                 300                 


Arg Gly Thr Val Tyr Ser Lys Ser Leu Glu Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Ile Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Phe Thr Thr Ser Ile Leu Ala Glu Asp Lys Ser Val Gln Ser Val Ile 
            340                 345                 350         


Ser Phe Asp Gln Gly Gly Glu Trp Val Pro Leu Arg Lys Pro Ala Asp 
        355                 360                 365             


Ser Lys Cys Asp Ala Thr Ala Arg Asp Pro Glu Lys Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ala Tyr Ser Ile Ala Thr Gly Leu Asn Val Pro Met Leu 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Leu Val Leu Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Arg Pro Asp Val Tyr Val Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Thr Trp Ile Lys Ala Leu Glu Gly Pro His His Tyr 
        435                 440                 445             


Ala Ile Leu Asp Ser Gly Gly Leu Leu Val Ala Val Glu Gln Asn Ala 
    450                 455                 460                 


His Gln Gly Val Asn Gln Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys 
465                 470                 475                 480 


Trp Gly Val Tyr Asn Phe Thr Lys Asp Pro Ile Phe Phe Thr Gly Leu 
                485                 490                 495     


Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Val Ser Leu Trp Gly Tyr 
            500                 505                 510         


Arg Ser Ser Leu Phe His Gln Tyr Trp Ile Ser Phe Thr Ile Asp Phe 
        515                 520                 525             


Arg Asp Leu Ile Thr Arg Asn Cys Thr Asp Lys Asp Tyr Val Gln Trp 
    530                 535                 540                 


Leu Ala His Ser Asp Asp Ile Ser Asp Pro Asn Asp Gly Cys Met Leu 
545                 550                 555                 560 


Gly Tyr Lys Glu Lys Phe Leu Arg Leu Lys Lys Asp Ser Val Cys Leu 
                565                 570                 575     


Asn Gly Arg Asp Tyr Glu Val Asn Thr Gln Pro Thr Pro Cys Leu Cys 
            580                 585                 590         


Thr Leu Asp Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Lys Glu Asn 
        595                 600                 605             


Ser Ser Glu Cys Val Glu Gln Pro Asp Leu Lys Gly Lys Val Leu Glu 
    610                 615                 620                 


Phe Cys Leu His Gly Thr Glu Glu Glu Leu Leu Thr Asn Gly Tyr Arg 
625                 630                 635                 640 


Lys Ile Pro Gly Asp Lys Cys Glu Gly Gly Gln Ile Pro Glu Arg Lys 
                645                 650                 655     


Glu Ile Asn Leu Arg Arg Arg Cys Val Ser Asp Leu Leu Gly Pro Glu 
            660                 665                 670         


Phe Leu Val Lys Lys Ser Ser Gly Ser Ala Gly Gly Ser Gly Gly Leu 
        675                 680                 685             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700     


<210>  151
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_hRIM

<400>  151

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ala Trp Val Gly Asp Gly Thr Gly Val Ile Leu 
        35                  40                  45              


Ala Leu Thr Thr Phe Gln Val Pro Ile Phe Met Ile Thr Ile Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Ser Asp Phe Gly Ile Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Ile Leu Thr Ala Asp Val Ser 
            100                 105                 110         


Gly Ser His Gly Ser Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn 
        115                 120                 125             


Phe Val Gln Thr Asp Leu Pro Phe Val Pro Leu Met Gln Ile Thr Tyr 
    130                 135                 140                 


Asn Pro Glu Asn Ser Asn Val Leu Leu Ala Leu Ser Asn Lys Asn Glu 
145                 150                 155                 160 


Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Asp 
                165                 170                 175     


Thr Val Cys Leu Ala Lys Trp Gly Arg Lys Gly Thr Ile Phe Phe Thr 
            180                 185                 190         


Ala Asn His Asn Gly Ser Cys Ser Asn Asp Arg Gly Met Leu Glu Leu 
        195                 200                 205             


Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Lys Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Thr Gly Lys Gly Thr Leu Arg Arg Ile His Val Ser Thr Asp Gln Gly 
                245                 250                 255     


Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly His Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Glu Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Ser Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Ile Asn Val Thr Ser Leu Arg Gly Val Phe 
                325                 330                 335     


Thr Thr Ser Ile Leu Ala Glu Asp Lys Ser Ile Gln Thr Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ala Tyr Ser Ile Ala Thr Gly Leu Asn Val Pro Met Leu Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Leu Val Leu Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Arg Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His His Tyr Ala 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Leu Leu Val Ala Val Glu Gln Asn Ala His 
    450                 455                 460                 


Gln Gly Val Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Phe Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Val Ser Leu Trp Gly Tyr Arg 
            500                 505                 510         


Ser Ser Leu Phe His Gln Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  152
<211>  699
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_hB06-10

<400>  152

Arg Ser Thr Glu Gln Gly Glu Ser Cys Ser Gly Leu Leu Gly Ala Asp 
1               5                   10                  15      


Ala Lys Leu Ala Gly Asn Thr His Gln His Ile Phe Asn Asp Leu Ser 
            20                  25                  30          


Gly Ser Val Ser Leu Ala Trp Val Gly Asp Gly Thr Gly Val Ile Leu 
        35                  40                  45              


Ala Leu Thr Thr Phe Gln Val Pro Ile Phe Met Ile Thr Ile Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Ser Phe Glu Asp Val 
65                  70                  75                  80  


Thr Asn Leu Ile Asn Asn Thr Phe Ile Arg Ser Asp Phe Gly Ile Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Ile Leu Thr Ala Asp Val Ser 
            100                 105                 110         


Gly Ser His Gly Ser Arg Ile Phe Val Ser Ser Asp Phe Gly Lys Ser 
        115                 120                 125             


Phe Thr His Gln Glu Leu Pro Phe Val Pro Leu Met Gln Ile Thr Tyr 
    130                 135                 140                 


Asn Pro Glu Asn Ser Asn Val Leu Leu Ala Leu Ser Asn Lys Asn Glu 
145                 150                 155                 160 


Leu Trp Leu Ser Glu Asp Phe Gly Thr Asn Trp Lys Lys Leu Tyr Asp 
                165                 170                 175     


Thr Val Cys Leu Ala Lys Trp Gly Arg Lys Gly Thr Ile Phe Phe Thr 
            180                 185                 190         


Ala Asn His Asn Gly Ser Cys Ser Asn Asp Arg Gly Met Leu Glu Leu 
        195                 200                 205             


Glu Arg Thr Thr Asp Tyr Gly Lys Ser Phe Lys Thr Val Ala Ser Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Lys Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Thr Gly Lys Gly Thr Leu Arg Ala Ile His Val Ser Val Asp Asp Gly 
                245                 250                 255     


Asp Thr Trp Asn Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr 
                325                 330                 335     


Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg 
    450                 455                 460                 


Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser 
                485                 490                 495     


Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu 
            500                 505                 510         


Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp 
        515                 520                 525             


Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala 
    530                 535                 540                 


His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr 
545                 550                 555                 560 


Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly 
                565                 570                 575     


Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu 
            580                 585                 590         


Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser 
        595                 600                 605             


Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys 
    610                 615                 620                 


Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile 
625                 630                 635                 640 


Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys 
                645                 650                 655     


Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
            660                 665                 670         


Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn Asp 
        675                 680                 685             


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 


<210>  153
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_hB12390

<400>  153

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Thr Val Cys Leu Ala Lys Trp Gly Arg Lys Gly Thr Ile Phe Phe 
            180                 185                 190         


Thr Ala Asn His Asn Gly Ser Cys Ser Asn Asp Arg Gly Met Leu Glu 
        195                 200                 205             


Leu Glu Arg Thr Thr Asp Tyr Gly Lys Ser Phe Lys Thr Val Ala Ser 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Lys Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Thr Gly Lys Gly Thr Leu Arg Ala Ile His Val Ser Val Asp Asp 
                245                 250                 255     


Gly Asp Thr Trp Asn Met Ala Gln Leu Pro Pro Val Gly His Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Glu Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Ser Gly Phe Gly Thr Ile Tyr Val Ser Asp Asp 
    290                 295                 300                 


Arg Gly Thr Val Tyr Ser Lys Ser Leu Glu Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Ile Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Phe Thr Thr Ser Ile Leu Ala Glu Asp Lys Ser Val Gln Ser Val Ile 
            340                 345                 350         


Ser Phe Asp Gln Gly Gly Glu Trp Val Pro Leu Arg Lys Pro Ala Asp 
        355                 360                 365             


Ser Lys Cys Asp Ala Thr Ala Arg Asp Pro Glu Lys Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ala Tyr Ser Ile Ala Thr Gly Leu Asn Val Pro Met Leu 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Leu Val Leu Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Arg Pro Asp Val Tyr Val Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Thr Trp Ile Lys Ala Leu Glu Gly Pro His Tyr Tyr 
        435                 440                 445             


Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser 
    450                 455                 460                 


Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr 
            500                 505                 510         


Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  154
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECDBAP_hB45678

<400>  154

Arg Ser Thr Glu Gln Gly Glu Ser Cys Ser Gly Leu Leu Gly Ala Asp 
1               5                   10                  15      


Ala Lys Leu Ala Gly Asn Thr His Gln His Ile Phe Asn Asp Leu Ser 
            20                  25                  30          


Gly Ser Val Ser Leu Ala Trp Val Gly Asp Gly Thr Gly Val Ile Leu 
        35                  40                  45              


Ala Leu Thr Thr Phe Gln Val Pro Ile Phe Met Ile Thr Ile Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Ser Phe Glu Asp Val 
65                  70                  75                  80  


Thr Asn Leu Ile Asn Asn Thr Phe Ile Arg Ser Asp Phe Gly Ile Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Ile Leu Thr Ala Asp Val Ser 
            100                 105                 110         


Gly Ser His Gly Ser Arg Ile Phe Val Ser Ser Asp Phe Gly Lys Ser 
        115                 120                 125             


Phe Thr His Gln Glu Leu Pro Phe Val Pro Leu Met Gln Ile Thr Tyr 
    130                 135                 140                 


Asn Pro Glu Asn Ser Asn Val Leu Leu Ala Leu Ser Asn Lys Asn Glu 
145                 150                 155                 160 


Leu Trp Leu Ser Glu Asp Phe Gly Thr Asn Trp Lys Lys Leu Tyr Asp 
                165                 170                 175     


Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr 
            180                 185                 190         


Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu 
        195                 200                 205             


Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly 
                245                 250                 255     


Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr 
                325                 330                 335     


Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His His Tyr Ala 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Leu Leu Val Ala Val Glu Gln Asn Ala His 
    450                 455                 460                 


Gln Gly Val Asn Gln Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gly Val Tyr Asn Phe Thr Lys Asp Pro Ile Phe Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Val Ser Leu Trp Gly Tyr Arg 
            500                 505                 510         


Ser Ser Leu Phe His Gln Tyr Trp Ile Ser Phe Thr Ile Asp Phe Arg 
        515                 520                 525             


Asp Leu Ile Thr Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Gly Ser Ala Gly Gly Ser Gly Gly Leu Asn 
        675                 680                 685             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700 


<210>  155
<211>  763
<212>  PRT
<213>  Artificial

<220>
<223>  Sortilin  SORTECD_HIS

<400>  155

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn His His His His His His His His 
        755                 760             


<210>  156
<211>  696
<212>  PRT
<213>  Artificial

<220>
<223>  HDX-MS Sequence

<400>  156

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu 
        195                 200                 205             


Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln 
                245                 250                 255     


Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp 
    290                 295                 300                 


Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile 
            340                 345                 350         


Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn 
        355                 360                 365             


Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr 
        435                 440                 445             


Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser 
    450                 455                 460                 


Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr 
            500                 505                 510         


Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Ser Gly Ser Ala Met Ile Glu Gly Arg Gly 
        675                 680                 685             


Val Gly His His His His His His 
    690                 695     


