                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals SA
 
<120>  Immunogenic Composition

<130>  VB66380P

<150>  GB1711635.1
<151>  2017-07-19

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Asp" or "Glu"

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa="Ser" or "Thr"

<400>  1

Xaa Xaa Asn Xaa Xaa 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence

<400>  2

Asp Gln Asn Ala Thr 
1               5   


<210>  3
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa="Asp" or "Glu"

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa="Ser" or "Thr"

<400>  3

Lys Xaa Xaa Asn Xaa Xaa Lys 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence

<400>  4

Lys Asp Gln Asn Ala Thr Lys 
1               5           


<210>  5
<211>  481
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Ser Arg Arg Phe Lys Lys Ser Gly Ser Gln Lys Val Lys Arg Ser 
1               5                   10                  15      


Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val Cys Phe Leu 
            20                  25                  30          


Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg Tyr Leu Asn 
        35                  40                  45              


Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val Gly Leu Leu 
    50                  55                  60                  


Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe Leu Leu Val 
65                  70                  75                  80  


Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val Gln Gln Phe 
                85                  90                  95      


Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr Ser Glu Tyr 
            100                 105                 110         


Ser Ile Ser Val Ala Val Leu Ala Asp Ser Asp Ile Glu Asn Val Thr 
        115                 120                 125             


Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asp Asn Glu Asn Ile 
    130                 135                 140                 


Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr Asp Leu Thr 
145                 150                 155                 160 


Val Asn Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser Leu Ile Ala 
                165                 170                 175     


Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu Asn Ile Ile 
            180                 185                 190         


Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys Ile Tyr Thr 
        195                 200                 205             


Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser Lys Asn Gln 
    210                 215                 220                 


Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly Pro Ile Ser 
225                 230                 235                 240 


Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val Asn Arg Asp 
                245                 250                 255     


Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala Tyr Val Pro 
            260                 265                 270         


Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr His Ala Gly 
        275                 280                 285             


Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn Leu Tyr Gly 
    290                 295                 300                 


Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser Phe Leu Lys 
305                 310                 315                 320 


Leu Ile Asp Leu Leu Gly Gly Ile Asp Val Tyr Asn Asp Gln Glu Phe 
                325                 330                 335     


Thr Ala His Thr Asn Gly Lys Tyr Tyr Pro Ala Gly Asn Val His Leu 
            340                 345                 350         


Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr Ser Leu Ala 
        355                 360                 365             


Asp Gly Asp Arg Asp Arg Gly Arg Asn Gln Gln Lys Val Ile Val Ala 
    370                 375                 380                 


Ile Leu Gln Lys Leu Thr Ser Thr Glu Ala Leu Lys Asn Tyr Ser Thr 
385                 390                 395                 400 


Ile Ile Asn Ser Leu Gln Asp Ser Ile Gln Thr Asn Met Pro Leu Glu 
                405                 410                 415     


Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly Gly Asn Tyr 
            420                 425                 430         


Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Thr Asp Leu Pro 
        435                 440                 445             


Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Met Glu Ile Asp Asp 
    450                 455                 460                 


Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val Met Glu Gly 
465                 470                 475                 480 


Arg 
    


<210>  6
<211>  243
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  6

Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
1               5                   10                  15      


Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Thr Glu Ser Tyr Arg Gln 
            20                  25                  30          


Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
        35                  40                  45              


Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
    50                  55                  60                  


Ile Ala Lys Glu Val Ala Asp Asp Leu Val Ile Ala Tyr Gly Ala Glu 
65                  70                  75                  80  


Ile Tyr Tyr Thr Leu Asp Ala Leu Glu Lys Leu Glu Lys Lys Glu Ile 
                85                  90                  95      


Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
            100                 105                 110         


Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 
        115                 120                 125             


Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
    130                 135                 140                 


Asn Asn Gly Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 
145                 150                 155                 160 


Gln Ile Asn Ser Tyr His Val Ser Lys Pro Lys Phe Phe Gly Glu Lys 
                165                 170                 175     


Tyr Lys Phe Met Lys Lys Arg Ala Arg Tyr Phe Leu Glu Arg Asp Leu 
            180                 185                 190         


Val His Val Val Ala Ser Asp Met His Asn Leu Asp Ser Arg Pro Pro 
        195                 200                 205             


Tyr Met Gln Gln Ala Tyr Asp Ile Ile Ala Lys Lys Tyr Gly Ala Lys 
    210                 215                 220                 


Lys Ala Lys Glu Leu Phe Val Asp Asn Pro Arg Lys Ile Ile Met Asp 
225                 230                 235                 240 


Gln Leu Ile 
            


<210>  7
<211>  230
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  7

Met Lys Glu Gln Asn Thr Leu Glu Ile Asp Val Leu Gln Leu Phe Arg 
1               5                   10                  15      


Ala Leu Trp Lys Arg Lys Leu Val Ile Leu Leu Val Ala Ile Ile Thr 
            20                  25                  30          


Ser Ser Val Ala Phe Thr Tyr Ser Thr Phe Val Ile Lys Pro Glu Phe 
        35                  40                  45              


Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Gly Glu Lys 
    50                  55                  60                  


Ser Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asp Val Leu Glu Glu Val Val 
                85                  90                  95      


Ser Asp Leu Lys Leu Asp Leu Thr Pro Lys Gly Leu Ala Asn Lys Ile 
            100                 105                 110         


Lys Val Thr Val Pro Val Asp Thr Arg Ile Val Ser Val Ser Val Asn 
        115                 120                 125             


Asp Arg Val Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg Glu 
    130                 135                 140                 


Val Ala Ala Gln Lys Ile Ile Ser Ile Thr Arg Val Ser Asp Val Thr 
145                 150                 155                 160 


Thr Leu Glu Glu Ala Arg Pro Ala Ile Ser Pro Ser Ser Pro Asn Ile 
                165                 170                 175     


Lys Arg Asn Ile Leu Ile Gly Phe Leu Ala Gly Val Ile Gly Thr Ser 
            180                 185                 190         


Val Ile Val Leu Leu Leu Glu Leu Leu Asp Thr Arg Val Lys Arg Pro 
        195                 200                 205             


Glu Asp Ile Glu Asp Thr Leu Gln Met Thr Leu Leu Gly Val Val Pro 
    210                 215                 220                 


Asn Leu Asn Lys Leu Lys 
225                 230 


<210>  8
<211>  227
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  8

Met Pro Thr Leu Glu Ile Ala Gln Lys Lys Leu Glu Phe Ile Lys Lys 
1               5                   10                  15      


Ala Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Ile Gln Leu Ser Gly 
            20                  25                  30          


Asp Lys Leu Lys Val Ile Ser Val Thr Ser Val Ser Pro Gly Glu Gly 
        35                  40                  45              


Lys Thr Thr Thr Ser Val Asn Ile Ala Trp Ser Phe Ala Arg Ala Gly 
    50                  55                  60                  


Tyr Lys Thr Leu Leu Ile Asp Gly Asp Thr Arg Asn Ser Val Ile Ser 
65                  70                  75                  80  


Gly Phe Phe Lys Ser Arg Glu Lys Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      


Ser Gly Thr Ala Asp Leu Ser His Gly Leu Cys Asp Thr Asn Ile Glu 
            100                 105                 110         


Asn Leu Phe Val Val Gln Ser Gly Ser Val Ser Pro Asn Pro Thr Ala 
        115                 120                 125             


Leu Leu Gln Ser Lys Asn Phe Asn Asp Met Ile Glu Thr Leu Arg Lys 
    130                 135                 140                 


Tyr Phe Asp Tyr Ile Ile Val Asp Thr Ala Pro Ile Gly Ile Val Ile 
145                 150                 155                 160 


Asp Ala Ala Ile Ile Thr Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     


Ala Thr Gly Glu Ala Asn Lys Arg Asp Val Gln Lys Ala Lys Gln Gln 
            180                 185                 190         


Leu Lys Gln Thr Gly Lys Leu Phe Leu Gly Val Val Leu Asn Lys Leu 
        195                 200                 205             


Asp Ile Ser Val Asp Lys Tyr Gly Val Tyr Gly Phe Tyr Gly Asn Tyr 
    210                 215                 220                 


Gly Lys Lys 
225         


<210>  9
<211>  455
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  9

Met Asp Glu Lys Gly Leu Lys Ile Phe Met Ala Val Leu Gln Ser Ile 
1               5                   10                  15      


Ile Val Ile Leu Leu Val Tyr Phe Leu Ser Phe Val Arg Glu Thr Glu 
            20                  25                  30          


Leu Glu Arg Ser Ser Met Val Ile Leu Tyr Leu Leu His Phe Phe Val 
        35                  40                  45              


Phe Tyr Val Ser Ser Tyr Gly Asn Asn Phe Phe Lys Arg Gly Tyr Leu 
    50                  55                  60                  


Val Glu Phe Asn Ser Thr Ile Arg Tyr Ile Phe Phe Phe Ala Ile Ala 
65                  70                  75                  80  


Ile Ser Val Leu Asn Phe Phe Ile Ala Glu Arg Phe Ser Ile Ser Arg 
                85                  90                  95      


Arg Gly Met Val Tyr Phe Leu Thr Leu Glu Gly Ile Ser Leu Tyr Leu 
            100                 105                 110         


Leu Asn Phe Leu Val Lys Lys Tyr Trp Lys His Val Phe Phe Asn Leu 
        115                 120                 125             


Lys Asn Ser Lys Lys Ile Leu Leu Leu Thr Val Thr Lys Asn Met Glu 
    130                 135                 140                 


Lys Val Leu Asp Lys Leu Leu Glu Ser Asp Glu Leu Ser Trp Lys Leu 
145                 150                 155                 160 


Val Ala Val Ser Val Leu Asn Lys Ser Asp Phe Gln His Asp Lys Ile 
                165                 170                 175     


Pro Val Ile Glu Lys Glu Lys Ile Ile Glu Phe Ala Thr His Glu Val 
            180                 185                 190         


Val Asp Glu Val Phe Val Asn Leu Pro Gly Glu Ser Tyr Asp Ile Gly 
        195                 200                 205             


Glu Ile Ile Ser Arg Phe Glu Thr Met Gly Ile Asp Val Thr Val Asn 
    210                 215                 220                 


Leu Lys Ala Phe Asp Lys Asn Leu Gly Arg Asn Lys Gln Ile His Glu 
225                 230                 235                 240 


Met Val Gly Leu Asn Val Val Thr Phe Ser Thr Asn Phe Tyr Lys Thr 
                245                 250                 255     


Ser His Val Ile Ser Lys Arg Ile Leu Asp Ile Cys Gly Ala Thr Ile 
            260                 265                 270         


Gly Leu Ile Leu Phe Ala Ile Ala Ser Leu Val Leu Val Pro Leu Ile 
        275                 280                 285             


Arg Lys Asp Gly Gly Pro Ala Ile Phe Ala Gln Thr Arg Ile Gly Lys 
    290                 295                 300                 


Asn Gly Arg His Phe Thr Phe Tyr Lys Phe Arg Ser Met Arg Ile Asp 
305                 310                 315                 320 


Ala Glu Ala Ile Lys Glu Gln Leu Met Asp Gln Asn Thr Met Gln Gly 
                325                 330                 335     


Gly Met Phe Lys Ile Asp Asn Asp Pro Arg Val Thr Lys Ile Gly Arg 
            340                 345                 350         


Phe Ile Arg Lys Thr Ser Leu Asp Glu Leu Pro Gln Phe Trp Asn Val 
        355                 360                 365             


Phe Ile Gly Asp Met Ser Leu Val Gly Thr Arg Pro Pro Thr Val Asp 
    370                 375                 380                 


Glu Tyr Asp Gln Tyr Thr Pro Glu Gln Lys Arg Arg Leu Ser Phe Lys 
385                 390                 395                 400 


Pro Gly Ile Thr Gly Leu Trp Gln Val Ser Gly Arg Ser Lys Ile Thr 
                405                 410                 415     


Asp Phe Asp Asp Val Val Lys Leu Asp Val Ser Tyr Ile Asp Asn Trp 
            420                 425                 430         


Thr Ile Trp Lys Asp Ile Glu Ile Leu Leu Lys Thr Val Lys Val Val 
        435                 440                 445             


Phe Met Arg Asp Gly Ala Lys 
    450                 455 


<210>  10
<211>  392
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Lys Lys Ser Val Tyr Ile Ile Gly Ser Lys Gly Ile Pro Ala Lys 
1               5                   10                  15      


Tyr Gly Gly Phe Glu Thr Phe Val Glu Lys Leu Thr Ala Phe Gln Gln 
            20                  25                  30          


Asp Lys Ala Ile Gln Tyr Tyr Val Ala Cys Met Arg Glu Asn Ser Ala 
        35                  40                  45              


Lys Ser Gly Thr Thr Glu Asp Val Phe Glu His Asn Gly Ala Ile Cys 
    50                  55                  60                  


Tyr Asn Val Asp Val Pro Asn Ile Gly Pro Ala Arg Ala Ile Val Tyr 
65                  70                  75                  80  


Asp Ile Ala Ala Ile Asn Arg Ala Ile Glu Ile Ala Lys Glu Asn Lys 
                85                  90                  95      


Asp Glu Asp Pro Ile Phe Tyr Ile Leu Ala Cys Arg Ile Gly Pro Phe 
            100                 105                 110         


Ile His Gly Ile Lys Lys Lys Ile Gln Ala Ile Gly Gly Thr Leu Leu 
        115                 120                 125             


Val Asn Pro Asp Gly His Glu Trp Leu Arg Ala Lys Trp Ser Thr Pro 
    130                 135                 140                 


Val Arg Arg Tyr Trp Lys Ile Ser Glu Gly Leu Met Val Lys His Ala 
145                 150                 155                 160 


Asp Leu Leu Val Cys Asp Ser Lys Asn Ile Glu Gln Tyr Ile Gln Glu 
                165                 170                 175     


Asp Tyr Lys Gln Phe Gln Pro Lys Thr Thr Tyr Ile Ala Tyr Gly Thr 
            180                 185                 190         


Asp Thr Thr Arg Ser Ile Leu Lys Ser Ser Asp Glu Lys Val Arg Ser 
        195                 200                 205             


Trp Phe Lys Glu Lys Asn Val Ser Glu Asn Glu Tyr Tyr Leu Val Val 
    210                 215                 220                 


Gly Arg Phe Val Pro Glu Asn Asn Tyr Glu Ser Met Ile Leu Gly Phe 
225                 230                 235                 240 


Leu Ala Ser Asn Ser Lys Lys Asp Phe Val Leu Ile Thr Asn Val Glu 
                245                 250                 255     


Gln Asn Lys Phe Tyr Asn Gln Leu Leu Ala Lys Thr Gly Phe Asp Lys 
            260                 265                 270         


Asp Pro Arg Val Lys Phe Val Gly Thr Val Tyr Asn Gln Glu Leu Leu 
        275                 280                 285             


Lys Tyr Ile Arg Glu Asn Ala Phe Ala Tyr Phe His Gly His Glu Val 
    290                 295                 300                 


Gly Gly Thr Asn Pro Ser Leu Leu Glu Ala Leu Ala Ser Thr Lys Leu 
305                 310                 315                 320 


Asn Leu Leu Leu Asp Val Gly Phe Asn Arg Glu Val Ala Glu Asp Gly 
                325                 330                 335     


Ala Asp Tyr Trp Glu Lys Asp Asn Leu His Lys Val Ile Glu Ala Ser 
            340                 345                 350         


Glu Gln Lys Thr Gln Glu Glu Ile Asn Glu Lys Asn Ile Leu Ser Thr 
        355                 360                 365             


Lys Gln Val Thr Glu Arg Phe Ser Trp Asp Leu Ile Val Asn Glu Tyr 
    370                 375                 380                 


Glu Lys Leu Phe Thr Arg Lys Asn 
385                 390         


<210>  11
<211>  468
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  11

Met Arg Tyr Gly Ile Met Arg Ile Ser Phe Ser Lys Lys Thr Met Leu 
1               5                   10                  15      


Cys Gly Leu Leu Tyr Ile Gly Leu Ile Leu Ser Val Val Thr Ile Pro 
            20                  25                  30          


Thr Ile Val Thr Phe Leu Tyr Ser Leu Leu Phe Ile Gly Ile Val Thr 
        35                  40                  45              


Val Leu Asn Tyr Asn Ser Ile Leu Ala Ser Asp Glu Asp Ala Asn Ser 
    50                  55                  60                  


Phe Phe Val Ala Leu Pro Ile Ile Leu Ser Ser Phe Gln Asn Val Tyr 
65                  70                  75                  80  


Leu Gly Phe Gly Ala Asp Arg Leu Asn Ser Val Thr Leu Gln Val Leu 
                85                  90                  95      


Leu Ser Ile Ser Ile Ala Ile Ile Thr Ile Thr Val Phe Leu Gly Ile 
            100                 105                 110         


Ile Leu Asn Arg Phe Lys Ser Lys Glu Phe Ser Trp Leu Val Leu Ser 
        115                 120                 125             


Ile Leu Val Ile Ile Ile Gln Ser Val Ile Leu Leu Ile Phe Phe Pro 
    130                 135                 140                 


Thr Thr Leu Pro Ala Tyr Leu Ser Ser Met Arg Asn Ile Leu Ala Pro 
145                 150                 155                 160 


Leu Leu Ile Phe Tyr Phe Ser Ile Tyr Gly Phe Lys Asn Ile Asn Leu 
                165                 170                 175     


Gln Lys Phe Tyr Lys Tyr Met Phe Ile Ile Ile Leu Val Val Leu Ile 
            180                 185                 190         


Phe Gly Phe Ile Glu Tyr Ile Tyr Gly Asn Ser Leu Trp Thr Arg Leu 
        195                 200                 205             


Asn Ile Lys Lys Leu Trp Ala Leu Lys Gly Leu Ala Ile Glu Asn Arg 
    210                 215                 220                 


Val Val Pro Gly Asn Trp His Ser Ser Glu Leu Ile Gly Gly Lys Gln 
225                 230                 235                 240 


Leu Arg Arg Met Val Ser Thr Phe Ala Asp Pro Val Asn Leu Gly Ser 
                245                 250                 255     


Tyr Leu Phe Ala Ala Phe Met Leu Ala Trp Tyr Lys Asn Lys Lys Leu 
            260                 265                 270         


Leu Gln Val Leu Leu Leu Ala Ser Phe Val Leu Ser Val Ser Lys Ala 
        275                 280                 285             


Ala Phe Leu Ser Met Leu Val Tyr Ile Ile Ile Tyr Thr Trp Val Val 
    290                 295                 300                 


Asp Lys Asn Lys Ile Leu Ser Ile Phe Gly Ile Ile Ile Ser Thr Val 
305                 310                 315                 320 


Leu Gly Leu Tyr Phe Tyr Asn Phe Ser Gln Val Ser Ser Tyr Gly Ser 
                325                 330                 335     


Ile Asn Ala His Ile Asp Gly Phe Phe Ser Ala Leu Ser Thr Pro Leu 
            340                 345                 350         


His Tyr Pro Phe Gly Met Gly Val Gly Ser Val Gly Val Leu Ala Ser 
        355                 360                 365             


Lys Leu Gly Ser Gln Thr Ala Leu Ser Ser Glu Val Leu Glu Thr Gly 
    370                 375                 380                 


Ile Gly Met Ile Ile Ala Gln Leu Gly Phe Val Gly Val Ile Ile Tyr 
385                 390                 395                 400 


Leu Ile Phe Phe Val Lys Leu Ser Val Ile Gly Lys Asn Ile Asn Asn 
                405                 410                 415     


Lys Arg Asp Lys Ile Leu Trp Phe Thr Leu Ile Tyr Ser Phe Leu Ala 
            420                 425                 430         


Asn Ala Phe Phe Asn Glu Val Ala Leu Ser Pro Asn Ser Cys Thr Leu 
        435                 440                 445             


Tyr Phe Leu Ile Leu Gly Leu Leu Tyr Asn Lys Asn Lys Ile Arg Ser 
    450                 455                 460                 


Thr Glu Phe Ser 
465             


<210>  12
<211>  323
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Glu Lys Leu Val Ser Ile Ile Leu Pro Val Tyr Asn Val Glu Gln 
1               5                   10                  15      


Tyr Ile Lys Asn Cys Leu Glu Ser Ile Gln Gln Gln Thr Tyr Pro Asn 
            20                  25                  30          


Leu Glu Val Ile Ile Val Asn Asp Gly Ser Thr Asp Lys Ser Val Glu 
        35                  40                  45              


Tyr Cys Glu Gln Ile Cys Lys Ile Asp Ser Arg Phe Ser Ile Thr His 
    50                  55                  60                  


Lys Glu Asn Gly Gly Leu Ser Asp Ala Arg Asn Val Gly Ile Asp Lys 
65                  70                  75                  80  


Ala Lys Gly Asp Tyr Leu Ile Phe Val Asp Ser Asp Asp Phe Val Ser 
                85                  90                  95      


Gln Asp Met Val Ser Tyr Leu Val Ser Cys Met Glu Asn Asn Glu Ala 
            100                 105                 110         


Asp Ile Ala Ile Cys Asp Pro Val His Tyr Tyr Ser Asp Arg Gln Asn 
        115                 120                 125             


Asn Asp Leu Asn Ile Phe Ser Pro Ala Ser Ser Val Lys Val Tyr Glu 
    130                 135                 140                 


Thr Thr Glu Ala Leu Cys Glu Met Phe Tyr Gln Lys Ser Phe Leu Val 
145                 150                 155                 160 


Ser Ala Trp Ala Lys Ile Phe Lys Arg Glu Leu Phe Asp Asp Ile Arg 
                165                 170                 175     


Phe Pro Val Gly Lys Leu Phe Glu Asp Ser Ala Ile Met Tyr Leu Leu 
            180                 185                 190         


Leu Glu Lys Cys Glu Thr Ile Ala Tyr Ser Asp Ala Lys Leu Tyr Ala 
        195                 200                 205             


Tyr Val His Arg Asp Asn Ser Ile Thr Thr Lys Lys Phe Ser Asp Arg 
    210                 215                 220                 


Asp Leu Asp Ile Leu Glu Ile Thr Asn Thr Ile Ile Asn His Tyr Gly 
225                 230                 235                 240 


Asp Asn Leu Arg Val Tyr Thr Ala Ala Val Ser Tyr Lys Val Ser Ala 
                245                 250                 255     


Cys Phe Arg Ile Leu Leu Asn Ser Pro Ser Glu Glu Lys Tyr Lys Lys 
            260                 265                 270         


Val Gln Lys Glu Cys Leu Ser Tyr Ile Leu Gln Asn Trp Arg Asn Ile 
        275                 280                 285             


Leu Phe Asn Asn Asn Val Arg Leu Lys Asn Lys Leu Ala Leu Ile Ser 
    290                 295                 300                 


Ile Thr Ile Phe Asn Pro Phe Val Lys Leu Ile Tyr Ser Lys Val Asn 
305                 310                 315                 320 


Arg Trp Glu 
            


<210>  13
<211>  410
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  13

Met Asn Lys Tyr Glu Glu Arg Tyr Gln Glu Asn Leu Ser Lys Asn Asp 
1               5                   10                  15      


Phe Tyr Lys Leu Ile Asn Lys Ser Tyr Leu Ser Asp Lys Glu Leu Gln 
            20                  25                  30          


Val Gln Gln Val Lys Ala Gly Ile Val Leu Pro Pro Lys Ala Phe Glu 
        35                  40                  45              


Thr Lys Leu Ser Asn Lys Leu Gly Leu Gln Lys Ser Leu His Gly Lys 
    50                  55                  60                  


Gly Gly Val Val Asp Ser Asn Gly Asn Tyr Ile Glu Leu Ser Ala Gln 
65                  70                  75                  80  


Lys Ala Val Gly Met Arg Asn Arg Val Tyr Gly Pro Tyr Lys Ile Asn 
                85                  90                  95      


Tyr Asp Asn Leu Pro Ile Arg Asn Glu Lys Val Ile Tyr Leu Asn Tyr 
            100                 105                 110         


Phe Ile Lys Gln Trp Gly His Phe Leu Leu Asp Val Val Gly Arg Leu 
        115                 120                 125             


Trp Tyr Pro Leu Leu Gln Asp Asn Asp Thr Lys Leu Val Tyr Thr Cys 
    130                 135                 140                 


Tyr Ala Gly Thr Glu Thr Lys Ile Glu Gly Asn Tyr Leu Glu Phe Leu 
145                 150                 155                 160 


Lys Leu Leu Gly Ile Asp Gln Ser Arg Leu Ile Met Ile Asn Cys Pro 
                165                 170                 175     


Thr Gln Phe Ser Glu Val Ile Ile Pro Glu Ser Ser Ile Leu Pro Gly 
            180                 185                 190         


Gly Tyr Tyr Thr Lys Glu Tyr Lys Gln Leu Phe Ser Ser Val Val Glu 
        195                 200                 205             


Asn Ile Lys Leu Asp Lys Tyr Asp Val Asn Ala Lys Met Ile Tyr Cys 
    210                 215                 220                 


Ser Arg Ser Lys Leu Gly Ile Ala Lys Ser Lys Glu Phe Gly Glu Asp 
225                 230                 235                 240 


Gly Ile Glu Gly Ile Phe Lys Gln Asn Gly Tyr Thr Ser Val Tyr Met 
                245                 250                 255     


Glu Thr Met Ser Leu Glu Glu Gln Ile Lys Thr Leu Leu Ser Ala Lys 
            260                 265                 270         


Thr Ile Val Leu Thr Ser Gly Ser Leu Ala His Asn Leu Leu Phe Val 
        275                 280                 285             


Asn Lys Asp Ile Asp Val Phe Ile Leu Asn Lys Thr Tyr Arg Val Asn 
    290                 295                 300                 


Leu His Gln Phe Leu Ile Asn Glu Ile Ser Asp Ala Thr Val Arg Phe 
305                 310                 315                 320 


Val Asp Ile Tyr Arg Ser Pro Leu Pro Ile Leu Tyr Gly Tyr Gly Pro 
                325                 330                 335     


Phe Leu Met Asp Leu Thr Lys Pro Leu Ala Asn Phe Leu Asp Asp Asn 
            340                 345                 350         


Glu Phe Val Tyr Glu Lys Gly Thr Val Leu Ser Lys Lys Asp Tyr Phe 
        355                 360                 365             


Lys Tyr Tyr Leu Lys Trp Leu Trp Ser Tyr Arg Phe Phe Leu Phe Arg 
    370                 375                 380                 


Leu Asn Gly Ile Lys Glu Gly Asn Ser Glu Phe Glu Lys Ser Phe Lys 
385                 390                 395                 400 


Ile Ile Arg Arg Tyr Tyr Lys Thr Gly Arg 
                405                 410 


<210>  14
<211>  461
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  14

Met Ser Lys Tyr Lys Glu Leu Ala Lys Asn Thr Gly Ile Phe Ala Leu 
1               5                   10                  15      


Ala Asn Phe Ser Ser Lys Ile Leu Ile Phe Leu Leu Val Pro Ile Tyr 
            20                  25                  30          


Thr Arg Val Leu Thr Thr Thr Glu Tyr Gly Phe Tyr Asp Leu Val Tyr 
        35                  40                  45              


Thr Thr Ile Gln Leu Phe Val Pro Ile Leu Thr Leu Asn Ile Ser Glu 
    50                  55                  60                  


Ala Val Met Arg Phe Leu Met Lys Asp Gly Val Ser Lys Lys Ser Val 
65                  70                  75                  80  


Phe Ser Ile Ala Val Leu Asp Ile Phe Ile Gly Ser Ile Ala Phe Ala 
                85                  90                  95      


Leu Leu Leu Leu Val Asn Asn Leu Phe Ser Leu Ser Asp Leu Ile Ser 
            100                 105                 110         


Gln Tyr Ser Ile Tyr Ile Phe Val Ile Phe Val Phe Tyr Thr Leu Asn 
        115                 120                 125             


Asn Phe Leu Ile Gln Phe Ser Lys Gly Ile Asp Lys Ile Gly Val Thr 
    130                 135                 140                 


Ala Ile Ser Gly Val Ile Ser Thr Ala Val Met Leu Ala Met Asn Val 
145                 150                 155                 160 


Ile Leu Leu Val Val Phe Asp Trp Gly Leu Leu Gly Phe Phe Ile Ala 
                165                 170                 175     


Asn Val Cys Gly Tyr Val Ile Pro Cys Ile Tyr Ile Val Ser Arg Leu 
            180                 185                 190         


Arg Leu Trp Glu Leu Phe Glu Ile Lys Ile Asp Lys Lys Leu Gln Trp 
        195                 200                 205             


Glu Met Val Tyr Tyr Ala Leu Pro Leu Val Leu Asn Ile Leu Ser Trp 
    210                 215                 220                 


Trp Val Asn Asn Thr Ser Asp Arg Tyr Ile Val Thr Ala Ile Val Gly 
225                 230                 235                 240 


Ile Gln Ala Ser Ala Ile Ile Ser Val Ala Tyr Lys Ile Pro Gln Ile 
                245                 250                 255     


Leu Ser Thr Ile Ser Ala Ile Phe Ile Gln Ser Trp Gln Ile Ser Ala 
            260                 265                 270         


Ile Lys Ile Gln Glu Asp Lys Ser Gly Thr Thr Phe Val Ser Asn Met 
        275                 280                 285             


Leu Leu Tyr Tyr Asn Ala Leu Leu Leu Ile Ile Ala Ser Gly Ile Ile 
    290                 295                 300                 


Leu Phe Val Lys Pro Ile Ser Asn Ile Leu Phe Gly Ile Ser Phe Tyr 
305                 310                 315                 320 


Ser Ala Trp Glu Leu Val Pro Phe Leu Ile Ile Ser Ser Leu Phe Asn 
                325                 330                 335     


Ala Ile Ser Gly Cys Ile Gly Ala Ile Met Gly Ala Lys Met Asp Thr 
            340                 345                 350         


His Asn Ile Ala Lys Ser Ala Leu Val Gly Met Ile Ala Asn Ile Ile 
        355                 360                 365             


Leu Asn Ile Val Leu Thr Phe Leu Met Gly Pro Gln Gly Ile Thr Ile 
    370                 375                 380                 


Ser Thr Leu Ile Ala Ser Phe Leu Ile Phe Tyr Met Arg Lys Asp Ser 
385                 390                 395                 400 


Val Lys Glu Ile Asn Ser Glu Thr Tyr Arg Ala Ile Tyr Leu Ser Trp 
                405                 410                 415     


Ile Leu Leu Val Val Glu Ala Cys Leu Leu Ile Tyr Met Asp Phe Ile 
            420                 425                 430         


Ile Gly Ala Leu Ile Ala Met Val Ile Asn Leu Phe Leu Leu Lys Asp 
        435                 440                 445             


Val Ile Lys Pro Leu Tyr Leu Lys Ile Phe Lys Arg Asn 
    450                 455                 460     


<210>  15
<211>  382
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  15

Met Ile Val Leu Gln Tyr Phe Lys Ile Leu Ala Arg Phe Val Phe Met 
1               5                   10                  15      


Phe Leu Ile Ser Ala Val Leu Leu Pro Phe Lys Ile Lys Pro Asn Lys 
            20                  25                  30          


Ile Val Phe Ile Asn Phe Asn Gly Lys Gly Tyr Gly Asp Asn Pro Lys 
        35                  40                  45              


Ser Ile Cys Glu Tyr Leu Arg Thr Thr Tyr Pro Asp Leu Asp Leu Val 
    50                  55                  60                  


Trp Leu Ala Arg Asp Asn Glu Gly Phe Pro Asp Gly Val Arg Val Val 
65                  70                  75                  80  


Lys Tyr Gly Thr Phe Gln Ala Phe Tyr Glu Gln Ala Ser Ser Lys Val 
                85                  90                  95      


Trp Val Tyr Asn Val Arg Ala Phe Ala Arg Ile Leu Lys Lys Arg Gly 
            100                 105                 110         


Gln Ile Tyr Ile Gln Thr Trp His Gly Ala Ser Ser Phe Lys Leu Ile 
        115                 120                 125             


Glu Lys Gln Ala Asp Leu Pro Ile Asn Tyr Val Leu Glu Ala Lys Tyr 
    130                 135                 140                 


Asp Ala Arg Val Thr Asp Ile Met Ile Ser Asp Ser Arg Lys Gln Thr 
145                 150                 155                 160 


Glu Glu Phe Gln Lys Tyr Phe Trp Tyr Ser Gly Glu Ile Phe Glu Val 
                165                 170                 175     


Gly Met Pro Arg Asn Asp Ala Leu Phe His Tyr Lys Glu Asp Tyr Asp 
            180                 185                 190         


Lys Leu Asn Asn Ile Arg Lys Glu Leu Ser Ile His Ser Asp Asp Tyr 
        195                 200                 205             


Val Ile Leu Tyr Ala Pro Thr Phe Arg Asp Asp Gly Asp Ala Ser Tyr 
    210                 215                 220                 


Leu Asp Ile Asn Phe Glu Arg Leu Leu Gln Cys Val Glu His Gly Ile 
225                 230                 235                 240 


Lys Lys Lys Cys Lys Phe Leu Ile Arg Leu His Pro Asn His Ser His 
                245                 250                 255     


Leu Cys Asn Asn Ile Ser Phe Asn Lys Asn Ile Ile Asn Ala Thr Phe 
            260                 265                 270         


Tyr Ser Asp Met Gln Glu Leu Thr Leu Leu Ala Asp Val Leu Val Thr 
        275                 280                 285             


Asp Tyr Ser Ser Ser Ile Phe Asp Phe Met Leu Leu Asn Lys Pro Tyr 
    290                 295                 300                 


Val Arg Tyr Val Asn Asp Leu Glu Lys Tyr Ala Glu Leu Arg Gly Val 
305                 310                 315                 320 


Ser Asp Thr Tyr Tyr Glu Leu Pro Asp Ser Ile Ile Lys Thr Ala Glu 
                325                 330                 335     


Glu Leu Tyr Asp Leu Leu Pro Lys Lys Ile Glu Asn Phe Asp Tyr Asp 
            340                 345                 350         


Ser Ile Lys Lys Tyr Arg Asn Glu Ile Leu Cys Pro Ile Phe Asn Gly 
        355                 360                 365             


Thr Ala Ser Glu Asn Val Gly Arg Arg Ile Ile Gln Glu Leu 
    370                 375                 380         


<210>  16
<211>  342
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  16

Met Lys Asn Asn Asp Leu Lys Ile Gly Ser Gly Ala Ile His Gln Ile 
1               5                   10                  15      


Ser Ala Thr Leu Ser Gln Asn Ser Ile Ser Gly Lys Ile Leu Tyr Cys 
            20                  25                  30          


Ala Asp Pro Val Val Asp Asp Leu Tyr Gly Ser Ile Val Arg Ser Gln 
        35                  40                  45              


Ile Glu Glu Ile Gly Arg Val Lys Glu Glu Ser Cys Asn Tyr Asn Thr 
    50                  55                  60                  


Ile Ala Tyr Ala Met Asn Ile Ala Glu Arg Ala Ile Ala Thr Asp Ile 
65                  70                  75                  80  


Asp Cys Ile Val Gly Met Gly Gly Gly Arg Val Leu Asp Val Cys Lys 
                85                  90                  95      


Tyr Ala Ser Phe Ile Ser Lys Arg Pro Tyr Leu Ser Ile Pro Thr Thr 
            100                 105                 110         


Ala Ala Asn Asp Gly Ile Ala Ser Pro Val Ala Val Leu Lys Arg Gln 
        115                 120                 125             


Asp Asp Arg Pro Lys Ser Leu Gly Ala Ala Ile Pro Ser Met Thr Leu 
    130                 135                 140                 


Ile Asp Ile Asp Val Ile Ala Ser Gly Pro Ile Gln Asn Ile Lys Ala 
145                 150                 155                 160 


Gly Ile Gly Asp Thr Ile Ser Asn Tyr Thr Ala Leu Lys Asp Trp Glu 
                165                 170                 175     


Leu Ala Val Glu Arg Gly Lys Asp Glu Met His Gly Phe Ala Tyr Leu 
            180                 185                 190         


Met Ser Gln Asn Ser Leu Asp Ala Leu Met Lys Thr Lys Tyr Asn Ser 
        195                 200                 205             


Ile Thr Pro Asp Phe Ile Glu Val Leu Val Asn Ser Leu Val Leu Ser 
    210                 215                 220                 


Gly Ile Ala Met Asp Phe Ala Gly Ser Ser Arg Pro Val Ser Gly Ser 
225                 230                 235                 240 


Glu His Leu Phe Ser His Ala Leu Asp Tyr Tyr Gly Ser Thr Arg Asn 
                245                 250                 255     


Leu His Gly Ile Gln Val Ala Leu Gly Thr Val Ala Val Leu Lys Leu 
            260                 265                 270         


Ile Glu Asn Ser Val Asp Thr Val Val Asp Tyr Leu Gln Arg Phe Glu 
        275                 280                 285             


Val His Ile Asn Pro Lys Leu Leu Gly Ile Asp Glu Glu Leu Phe Ile 
    290                 295                 300                 


Tyr Cys Met Gln His Ala Thr Lys Met Arg Ser Asn Arg Tyr Thr Tyr 
305                 310                 315                 320 


Leu His Glu Val Asp Leu Ser Thr Asp Arg Leu Lys Gln Ile Tyr Lys 
                325                 330                 335     


Glu Leu Ile Ser Glu Leu 
            340         


<210>  17
<211>  234
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  17

Met Lys Ala Leu Ile Leu Ala Ala Gly Leu Gly Thr Arg Leu Ala Pro 
1               5                   10                  15      


Ile Thr Asn Glu Val Pro Lys Ser Leu Val Pro Val Asn Gly Lys Pro 
            20                  25                  30          


Ile Leu Met Lys Gln Ile Glu Asn Leu Tyr Gln Asn Asn Ile Thr Asp 
        35                  40                  45              


Ile Thr Ile Ile Ala Gly Tyr Lys Ser Ser Val Leu Thr Asp Ala Val 
    50                  55                  60                  


Thr Glu Lys Tyr Pro Glu Ile Asn Ile Ile Asp Asn Val Asp Phe Lys 
65                  70                  75                  80  


Thr Thr Asn Asn Met Tyr Ser Ala Tyr Leu Gly Lys Ala Ala Met Gly 
                85                  90                  95      


Asp Ser Asp Phe Leu Met Met Asn Ala Asp Val Phe Tyr Asp Ala Ser 
            100                 105                 110         


Val Ile Lys Ser Leu Leu Leu His Lys Ala Pro Asn Ala Ile Val Thr 
        115                 120                 125             


Asp Leu Gly Ile Tyr Ile Glu Glu Ser Met Lys Val Val Glu Lys Asn 
    130                 135                 140                 


Gly Arg Leu Val Glu Ile Ser Lys Gln Ile Ser Pro Glu Glu Thr Leu 
145                 150                 155                 160 


Gly Ala Ser Ile Asp Val Tyr Lys Phe Ser Tyr Glu Ala Gly Ala Arg 
                165                 170                 175     


Phe Phe Glu Lys Cys Lys Glu Phe Ile Glu Asp Lys Arg Glu Leu Gln 
            180                 185                 190         


Met Trp Ser Glu Val Ala Leu Asn Ala Ile Leu Ser Glu Val Glu Phe 
        195                 200                 205             


Val Ala Cys Pro Leu Glu Gly Arg Trp Leu Glu Ile Asp Asn His Glu 
    210                 215                 220                 


Asp Leu Val Ala Ala Glu Lys Leu Phe Ala 
225                 230                 


<210>  18
<211>  277
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  18

Met Lys Leu Thr Asn Arg Val Asp Tyr Phe Gly Ala Asp Ile Ser Glu 
1               5                   10                  15      


Leu Gln Asn Lys Lys Leu Phe Leu Phe Asp Met Asp Gly Thr Ile Tyr 
            20                  25                  30          


Glu Glu Asp Arg Leu Phe Glu Gly Thr Leu Glu Leu Leu Asp Tyr Ile 
        35                  40                  45              


His Asn Ile Gly Gly Glu Tyr Ile Phe Ile Thr Asn Asn Ser Ser Lys 
    50                  55                  60                  


Ser Val Val Asp Tyr Val Glu Lys Val Asn Arg Leu Gly Ile Lys Ala 
65                  70                  75                  80  


Glu Arg Asp Asn Phe Phe Thr Ser Ala Gln Ala Thr Ile Val Tyr Ile 
                85                  90                  95      


Lys Glu Asn Tyr Pro Lys Ser Lys Val Tyr Cys Gln Gly Thr Lys Ser 
            100                 105                 110         


Leu Ile Lys Glu Leu Ser Asp Ala Gly Ile Asp Val Thr Glu Gln Val 
        115                 120                 125             


Ser Ala Asp Ile Asp Val Val Leu Val Gly Phe Asp Thr Glu Leu Thr 
    130                 135                 140                 


Ser Asp Lys Ile Arg Asn Thr Cys Glu Ile Leu Ser Thr Lys Asp Val 
145                 150                 155                 160 


Pro Phe Ile Ala Thr Asn Pro Asp Ile Arg Cys Pro Val Ser Phe Gly 
                165                 170                 175     


Phe Ile Pro Asp Cys Gly Ser Ile Cys Asp Met Ile Ser Lys Ser Val 
            180                 185                 190         


Asp Arg Lys Pro Val Tyr Ile Gly Lys Pro Glu Pro Thr Met Val Asp 
        195                 200                 205             


Ile Val Arg Lys Lys Leu Asn Tyr Ser Leu Phe Glu Thr Val Val Ile 
    210                 215                 220                 


Gly Asp Arg Leu Tyr Thr Asp Ile Met Thr Gly Ile Asn Ala Gly Val 
225                 230                 235                 240 


Thr Ser Val Cys Val Leu Thr Gly Glu Ala Thr Val Asn Asp Ile Gln 
                245                 250                 255     


Gln Asp Ser Ile Lys Pro Thr Tyr Thr Phe Lys Asn Val Lys Glu Met 
            260                 265                 270         


Trp Lys Gly Ile Val 
        275         


<210>  19
<211>  289
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  19

Met Lys Gly Ile Ile Leu Ala Gly Gly Ser Gly Thr Arg Leu Tyr Pro 
1               5                   10                  15      


Leu Thr Arg Ala Ala Ser Lys Gln Leu Met Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Thr Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Leu Ile Ile Ser Thr Pro Gln Asp Leu Pro Arg Phe Lys Glu Leu 
    50                  55                  60                  


Leu Gln Asp Gly Ser Glu Phe Gly Ile Lys Leu Ser Tyr Ala Glu Gln 
65                  70                  75                  80  


Pro Ser Pro Asp Gly Leu Ala Gln Ala Phe Ile Ile Gly Glu Glu Phe 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Ile Leu Gly Asp Asn Ile Tyr His 
            100                 105                 110         


Gly Pro Gly Leu Ser Thr Met Leu Gln Lys Ala Ala Lys Lys Glu Lys 
        115                 120                 125             


Gly Ala Thr Val Phe Gly Tyr His Val Lys Asp Pro Glu Arg Phe Gly 
    130                 135                 140                 


Val Val Glu Phe Asp Glu Asn Met Asn Ala Ile Ser Ile Glu Glu Lys 
145                 150                 155                 160 


Pro Glu Tyr Pro Arg Ser Asn Tyr Ala Val Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Glu Ile Ala Lys Ser Ile Lys Pro Ser Pro Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Lys Ala Tyr Leu Asp Arg Gly 
        195                 200                 205             


Asp Leu Ser Val Glu Leu Met Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Glu Ser Leu Leu Glu Ala Ser Gln Tyr Ile Glu Thr Val 
225                 230                 235                 240 


Gln Arg Met Gln Asn Val Gln Val Ala Asn Leu Glu Glu Ile Ala Tyr 
                245                 250                 255     


Arg Arg Gly Tyr Ile Ser Arg Glu Asp Val Leu Ala Leu Ala Gln Ser 
            260                 265                 270         


Leu Lys Lys Asn Glu Tyr Gly Gln Tyr Leu Leu Arg Leu Ile Gly Glu 
        275                 280                 285             


Ala 
    


<210>  20
<211>  197
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  20

Met Thr Asp Asn Phe Phe Gly Lys Thr Leu Ala Ala Arg Lys Val Glu 
1               5                   10                  15      


Ala Ile Pro Gly Met Leu Glu Phe Asp Ile Pro Val His Gly Asp Asn 
            20                  25                  30          


Arg Gly Trp Phe Lys Glu Asn Phe Gln Lys Glu Lys Met Leu Pro Leu 
        35                  40                  45              


Gly Phe Pro Glu Ser Phe Phe Ala Glu Gly Lys Leu Gln Asn Asn Val 
    50                  55                  60                  


Ser Phe Ser Arg Lys Asn Val Leu Arg Gly Leu His Ala Glu Pro Trp 
65                  70                  75                  80  


Asp Lys Tyr Ile Ser Val Ala Asp Gly Gly Lys Val Leu Gly Ser Trp 
                85                  90                  95      


Val Asp Leu Arg Glu Gly Glu Thr Phe Gly Asn Thr Tyr Gln Thr Val 
            100                 105                 110         


Ile Asp Ala Ser Lys Gly Ile Phe Val Pro Arg Gly Val Ala Asn Gly 
        115                 120                 125             


Phe Gln Val Leu Ser Asp Thr Val Ser Tyr Ser Tyr Leu Val Asn Asp 
    130                 135                 140                 


Tyr Trp Ala Leu Glu Leu Lys Pro Lys Tyr Ala Phe Val Asn Tyr Ala 
145                 150                 155                 160 


Asp Pro Ser Leu Gly Ile Glu Trp Glu Asn Ile Ala Glu Ala Glu Val 
                165                 170                 175     


Ser Glu Ala Asp Lys Asn His Pro Leu Leu Lys Asp Val Lys Pro Leu 
            180                 185                 190         


Lys Lys Glu Asp Leu 
        195         


<210>  21
<211>  349
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  21

Met Thr Glu Tyr Lys Asn Ile Ile Val Thr Gly Gly Ala Gly Phe Ile 
1               5                   10                  15      


Gly Ser Asn Phe Val His Tyr Val Tyr Glu Asn Phe Pro Asp Val His 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Ala Asn Ile 
        35                  40                  45              


Glu Glu Ile Leu Gly Asn Arg Val Glu Leu Val Val Gly Asp Ile Ala 
    50                  55                  60                  


Asp Ala Glu Leu Val Asp Lys Leu Ala Ala Gln Ala Asp Ala Ile Val 
65                  70                  75                  80  


His Tyr Ala Ala Glu Ser His Asn Asp Asn Ser Leu Asn Asp Pro Ser 
                85                  90                  95      


Pro Phe Ile His Thr Asn Phe Ile Gly Thr Tyr Thr Leu Leu Glu Ala 
            100                 105                 110         


Ala Arg Lys Tyr Asp Ile Arg Phe His His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Asp Leu Pro Leu Arg Glu Asp Leu Pro Gly His Gly Glu Gly 
    130                 135                 140                 


Pro Gly Glu Lys Phe Thr Ala Glu Thr Lys Tyr Asn Pro Ser Ser Pro 
145                 150                 155                 160 


Tyr Ser Ser Thr Lys Ala Ala Ser Asp Leu Ile Val Lys Ala Trp Val 
                165                 170                 175     


Arg Ser Phe Gly Val Lys Ala Thr Ile Ser Asn Cys Ser Asn Asn Tyr 
            180                 185                 190         


Gly Pro Tyr Gln His Ile Glu Lys Phe Ile Pro Arg Gln Ile Thr Asn 
        195                 200                 205             


Ile Leu Ser Gly Ile Lys Pro Lys Leu Tyr Gly Glu Gly Lys Asn Val 
    210                 215                 220                 


Arg Asp Trp Ile His Thr Asn Asp His Ser Ser Gly Val Trp Thr Ile 
225                 230                 235                 240 


Leu Thr Lys Gly Gln Ile Gly Glu Thr Tyr Leu Ile Gly Ala Asp Gly 
                245                 250                 255     


Glu Lys Asn Asn Lys Glu Val Leu Glu Leu Ile Leu Lys Glu Met Gly 
            260                 265                 270         


Gln Ala Val Asp Ala Tyr Asp His Val Thr Asp Arg Ala Gly His Asp 
        275                 280                 285             


Leu Arg Tyr Ala Ile Asp Ala Ser Lys Leu Arg Asp Glu Leu Gly Trp 
    290                 295                 300                 


Lys Pro Glu Phe Thr Asn Phe Glu Ala Gly Leu Lys Ala Thr Ile Lys 
305                 310                 315                 320 


Trp Tyr Thr Asp Asn Gln Glu Trp Trp Lys Ala Glu Lys Glu Ala Val 
                325                 330                 335     


Glu Ala Asn Tyr Ala Lys Thr Gln Glu Ile Ile Thr Val 
            340                 345                 


<210>  22
<211>  283
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  22

Met Ile Leu Ile Thr Gly Ala Asn Gly Gln Leu Gly Thr Glu Leu Arg 
1               5                   10                  15      


Tyr Leu Leu Asp Glu Arg Asn Glu Glu Tyr Val Ala Val Asp Val Ala 
            20                  25                  30          


Glu Met Asp Ile Thr Asp Ala Glu Met Val Glu Lys Val Phe Glu Glu 
        35                  40                  45              


Val Lys Pro Thr Leu Val Tyr His Cys Ala Ala Tyr Thr Ala Val Asp 
    50                  55                  60                  


Ala Ala Glu Asp Glu Gly Arg Glu Leu Asp Phe Ala Ile Asn Val Thr 
65                  70                  75                  80  


Gly Thr Lys Asn Val Ala Lys Ala Ser Glu Lys His Gly Ala Thr Leu 
                85                  90                  95      


Val Tyr Ile Ser Thr Asp Tyr Val Phe Asp Gly Lys Lys Pro Val Gly 
            100                 105                 110         


Gln Glu Trp Glu Val Asp Asp Arg Pro Asp Pro Gln Thr Glu Tyr Gly 
        115                 120                 125             


Arg Thr Lys Arg Met Gly Glu Glu Leu Val Glu Lys His Val Ser Asn 
    130                 135                 140                 


Phe Tyr Ile Ile Arg Thr Ala Trp Val Phe Gly Asn Tyr Gly Lys Asn 
145                 150                 155                 160 


Phe Val Phe Thr Met Gln Asn Leu Ala Lys Thr His Lys Thr Leu Thr 
                165                 170                 175     


Val Val Asn Asp Gln Tyr Gly Arg Pro Thr Trp Thr Arg Thr Leu Ala 
            180                 185                 190         


Glu Phe Met Thr Tyr Leu Ala Glu Asn Arg Lys Glu Phe Gly Tyr Tyr 
        195                 200                 205             


His Leu Ser Asn Asp Ala Thr Glu Asp Thr Thr Trp Tyr Asp Phe Ala 
    210                 215                 220                 


Val Glu Ile Leu Lys Gly Thr Asp Val Glu Val Lys Pro Val Asp Ser 
225                 230                 235                 240 


Ser Gln Phe Pro Ala Lys Ala Lys Arg Pro Leu Asn Ser Thr Met Ser 
                245                 250                 255     


Leu Ala Lys Ala Lys Ala Thr Gly Phe Val Ile Pro Thr Trp Gln Asp 
            260                 265                 270         


Ala Leu Gln Glu Phe Tyr Lys Gln Glu Val Arg 
        275                 280             


<210>  23
<211>  484
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  23

Met Leu Ile Met Ser Arg Arg Phe Lys Lys Ser Gly Ser Gln Lys Val 
1               5                   10                  15      


Lys Arg Ser Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val 
            20                  25                  30          


Cys Phe Leu Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg 
        35                  40                  45              


Tyr Phe Asn Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val 
    50                  55                  60                  


Gly Leu Leu Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe 
65                  70                  75                  80  


Leu Leu Val Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val 
                85                  90                  95      


Gln Gln Phe Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr 
            100                 105                 110         


Ser Glu Tyr Ser Ile Ser Val Ala Val Leu Ala Asp Ser Asp Ile Glu 
        115                 120                 125             


Asn Val Thr Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asp Asn 
    130                 135                 140                 


Glu Asn Ile Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Ile 
145                 150                 155                 160 


Asp Leu Thr Val Asn Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser 
                165                 170                 175     


Leu Ile Ala Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu 
            180                 185                 190         


Asn Ile Ile Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys 
        195                 200                 205             


Ile Tyr Thr Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser 
    210                 215                 220                 


Lys Asn Gln Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly 
225                 230                 235                 240 


Pro Ile Ser Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val 
                245                 250                 255     


Asn Arg Asp Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala 
            260                 265                 270         


Tyr Val Pro Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr 
        275                 280                 285             


His Ala Gly Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn 
    290                 295                 300                 


Leu Tyr Gly Val Asp Ile His Tyr Tyr Val Arg Leu Asn Phe Thr Ser 
305                 310                 315                 320 


Phe Leu Lys Leu Ile Asp Leu Leu Gly Gly Val Asp Val Tyr Asn Asp 
                325                 330                 335     


Gln Asp Phe Thr Ser Leu His Gly Lys Phe His Phe Pro Val Gly Asn 
            340                 345                 350         


Val His Leu Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr 
        355                 360                 365             


Ser Leu Ala Asp Gly Asp His Asp Arg Gly Arg Asn Gln Gln Lys Val 
    370                 375                 380                 


Ile Ala Ala Ile Leu Gln Lys Leu Thr Ser Ser Glu Ala Leu Lys Asn 
385                 390                 395                 400 


Tyr Ser Met Ile Ile Asp Ser Leu Gln Asp Ser Ile Gln Thr Asn Met 
                405                 410                 415     


Pro Leu Glu Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly 
            420                 425                 430         


Gly Thr Tyr Lys Val Asn Ser Gln Asp Leu Lys Gly Arg Gly Arg Thr 
        435                 440                 445             


Asp Leu Pro Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Met Met Glu 
    450                 455                 460                 


Ile Asn Asp Ser Ser Leu Ala Ser Val Lys Thr Ala Ile Gln Asp Val 
465                 470                 475                 480 


Leu Glu Gly Arg 
                


<210>  24
<211>  259
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  24

Met His Leu Ser Lys Leu Leu Phe Arg Met Cys Trp Arg Ala Asp Glu 
1               5                   10                  15      


Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
            20                  25                  30          


Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Thr Glu Ala Tyr Arg Gln 
        35                  40                  45              


Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
    50                  55                  60                  


Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
65                  70                  75                  80  


Ile Ala Lys Glu Val Ala Ser Asp Leu Val Ile Ala Tyr Gly Ala Glu 
                85                  90                  95      


Ile Tyr Tyr Thr Pro Asp Val Leu Gly Lys Leu Glu Lys Asn Arg Ile 
            100                 105                 110         


Pro Thr Leu Asn Asn Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
        115                 120                 125             


Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ile Lys Ile Leu Met Leu 
    130                 135                 140                 


Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
145                 150                 155                 160 


Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asn Met Gly Cys Tyr Thr 
                165                 170                 175     


Gln Val Asn Ser Ser His Val Leu Lys Ser Lys Leu Phe Gly Glu Pro 
            180                 185                 190         


Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Arg Asp Leu 
        195                 200                 205             


Val His Val Ile Ala Ser Asp Met His Asn Val Asp Ser Arg Pro Pro 
    210                 215                 220                 


His Met Ala Glu Ala Tyr Asp Leu Val Ser Gln Lys Tyr Gly Glu Thr 
225                 230                 235                 240 


Lys Ala Gln Asp Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 
                245                 250                 255     


Gln Leu Ile 
            


<210>  25
<211>  230
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  25

Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Leu Lys 
1               5                   10                  15      


Thr Leu Trp Lys His Lys Leu Ile Ile Leu Leu Val Ala Leu Val Thr 
            20                  25                  30          


Gly Ala Gly Ala Phe Ala Tyr Ser Ile Phe Ile Val Lys Pro Glu Tyr 
        35                  40                  45              


Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Glu Asn Lys 
    50                  55                  60                  


Pro Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val Lys 
65                  70                  75                  80  


Asp Tyr His Glu Ile Ile Leu Ser Gln Asp Val Leu Glu Lys Val Ala 
                85                  90                  95      


Thr Asn Leu Lys Leu Asp Ile Pro Val Lys Thr Leu Thr Ser Lys Val 
            100                 105                 110         


Gln Val Thr Val Pro Ala Asp Thr Arg Ile Val Ser Ile Ser Val Lys 
        115                 120                 125             


Asp Lys Gln Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Ile Arg Glu 
    130                 135                 140                 


Val Ala Ala Glu Lys Ile Ile Ala Val Thr Arg Val Ser Asp Val Thr 
145                 150                 155                 160 


Thr Leu Glu Glu Ala Arg Pro Ala Thr Thr Pro Ser Ser Pro Asn Val 
                165                 170                 175     


Arg Arg Asn Thr Leu Val Gly Phe Leu Gly Ala Ala Ala Val Thr Val 
            180                 185                 190         


Ile Thr Val Leu Leu Ile Glu Leu Phe Asp Thr Arg Val Lys Arg Pro 
        195                 200                 205             


Glu Glu Val Glu Asp Val Leu Gln Met Pro Leu Leu Gly Val Val Pro 
    210                 215                 220                 


Asp Phe Asn Lys Met Lys 
225                 230 


<210>  26
<211>  229
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  26

Met Pro Thr Leu Glu Ile Ser Gln Ala Lys Leu Glu Leu Ala Lys Lys 
1               5                   10                  15      


Thr Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Pro Gln Leu Ser Gly 
            20                  25                  30          


Asp Asp Leu Lys Val Phe Ser Ile Ser Ser Val Lys Ala Gly Glu Gly 
        35                  40                  45              


Lys Thr Thr Thr Ser Thr Asn Ile Ala Trp Ala Phe Ala His Ala Gly 
    50                  55                  60                  


Tyr Lys Thr Leu Leu Ile Asp Ala Asp Met Arg Asn Ser Val Met Ser 
65                  70                  75                  80  


Gly Val Phe Lys Ser Arg Glu Arg Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      


Ser Gly Thr Thr Asp Leu Ser Gln Gly Leu Cys Asp Thr Asn Val Glu 
            100                 105                 110         


Asn Leu Phe Val Ile Gln Ala Gly Ser Val Ser Pro Asn Pro Ile Ala 
        115                 120                 125             


Leu Leu Gln Ser Lys Asn Phe Ser Thr Met Leu Gly Thr Leu Arg Lys 
    130                 135                 140                 


Tyr Phe Asp Tyr Ile Val Val Asp Thr Ala Pro Ile Gly Ile Val Ile 
145                 150                 155                 160 


Asp Ala Ala Ile Ile Met Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     


Lys Ala Gly Glu Thr Lys Arg Arg Glu Leu Gln Lys Ala Lys Glu Gln 
            180                 185                 190         


Leu Glu Gln Thr Gly Lys Ser Cys Leu Gly Val Val Leu Asn Lys Phe 
        195                 200                 205             


Asp Thr Ser Val Asp Lys Tyr Gly Phe Tyr Gly Ser Tyr Gly Ser Tyr 
    210                 215                 220                 


Arg Lys Gln Lys Lys 
225                 


<210>  27
<211>  453
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  27

Met Asn Glu Lys Leu Ala Lys Ser Ser Val Ala Ile Val Gln Ser Phe 
1               5                   10                  15      


Leu Val Ile Leu Leu Thr Tyr Leu Leu Ser Ala Val Arg Glu Thr Glu 
            20                  25                  30          


Ile Val Ser Thr Thr Ala Ile Val Leu Tyr Ile Leu His Tyr Phe Val 
        35                  40                  45              


Phe Tyr Ile Ser Asp Tyr Gly Arg Asn Phe Phe Lys Arg Arg Tyr Leu 
    50                  55                  60                  


Ile Glu Leu Val Gln Thr Leu Lys Tyr Ile Leu Phe Phe Ala Leu Ala 
65                  70                  75                  80  


Ile Ser Ile Ser Asn Phe Phe Leu Glu Asp Arg Phe Ser Ile Ser Arg 
                85                  90                  95      


Arg Gly Met Ile Tyr Phe Leu Leu Leu His Val Phe Leu Val Tyr Met 
            100                 105                 110         


Leu Asn Leu Phe Ile Lys Trp Tyr Trp Lys Arg Ala Tyr Pro Asn Phe 
        115                 120                 125             


Lys Gly Ser Lys Lys Val Phe Leu Leu Thr Ala Thr Ser His Val Glu 
    130                 135                 140                 


Lys Val Leu Asp Arg Leu Ile Glu Ser Asp Asp Val Val Gly Glu Leu 
145                 150                 155                 160 


Val Ala Val Ser Val Leu Asp Lys Pro Asp Phe Gln His Asp Asp Leu 
                165                 170                 175     


Lys Val Val Ala Glu Gly Glu Ile Val Asn Phe Ala Thr Arg Glu Val 
            180                 185                 190         


Val Asp Glu Val Phe Ile Asn Leu Pro Ser Glu Lys Tyr Asn Ile Gly 
        195                 200                 205             


Glu Leu Val Ser Gln Phe Glu Thr Met Gly Ile Asp Val Thr Val Asn 
    210                 215                 220                 


Leu Asn Ala Phe Asp Trp Ala Arg Asn Lys Gln Ile Cys Glu Met Ala 
225                 230                 235                 240 


Gly Leu Asn Val Val Thr Phe Ser Thr Thr Phe Tyr Lys Thr Ser His 
                245                 250                 255     


Val Ile Ala Lys Arg Val Ile Asp Ile Ile Gly Ser Leu Val Gly Leu 
            260                 265                 270         


Ile Leu Cys Gly Leu Val Ser Ile Val Leu Val Pro Leu Ile Arg Lys 
        275                 280                 285             


Asp Gly Gly Ser Ala Ile Phe Ala Gln Thr Arg Ile Gly Lys Asn Gly 
    290                 295                 300                 


Arg His Phe Thr Phe Tyr Lys Phe Arg Ser Met Cys Val Asp Ala Glu 
305                 310                 315                 320 


Asp Lys Lys Arg Glu Leu Met Glu Gln Asn Thr Met Gln Gly Gly Met 
                325                 330                 335     


Phe Lys Val Asp Asp Asp Pro Arg Ile Thr Lys Ile Gly His Phe Ile 
            340                 345                 350         


Arg Lys Thr Ser Leu Asp Glu Leu Pro Gln Phe Tyr Asn Val Leu Lys 
        355                 360                 365             


Gly Asp Met Ser Leu Val Gly Thr Arg Pro Pro Thr Val Asp Glu Tyr 
    370                 375                 380                 


Glu His Tyr Thr Pro Glu Gln Lys Arg Arg Leu Ser Phe Lys Pro Gly 
385                 390                 395                 400 


Ile Thr Gly Leu Trp Gln Val Ser Gly Arg Ser Glu Ile Lys Asn Phe 
                405                 410                 415     


Asp Glu Val Val Lys Leu Asp Val Val Tyr Ile Asp Gly Trp Thr Ile 
            420                 425                 430         


Trp Lys Asp Ile Glu Ile Leu Leu Lys Thr Val Lys Val Val Leu Met 
        435                 440                 445             


Lys Asp Gly Ala Lys 
    450             


<210>  28
<211>  407
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  28

Met Glu Arg Asn Ser Leu Leu Leu Phe Gln Thr Ile Arg Arg Lys Met 
1               5                   10                  15      


Lys Lys Ser Val Tyr Ile Ile Gly Ser Lys Gly Ile Pro Ala Lys Tyr 
            20                  25                  30          


Gly Gly Phe Glu Thr Phe Val Glu Lys Leu Thr Glu Tyr Gln Lys Asp 
        35                  40                  45              


Gly Asn Ile Gln Tyr Tyr Val Ala Cys Met Arg Glu Asn Ser Ala Lys 
    50                  55                  60                  


Ser Gly Phe Thr Ala Asp Thr Phe Glu Tyr Asn Asp Ala Ile Cys Tyr 
65                  70                  75                  80  


Asn Ile Asp Val Pro Asn Ile Gly Pro Ala Arg Ala Ile Ala Tyr Asp 
                85                  90                  95      


Ile Ala Ala Val Asn Lys Ala Ile Glu Ile Ala Lys Lys Asn Lys Asp 
            100                 105                 110         


Glu Ala Pro Ile Phe Tyr Ile Leu Ala Cys Arg Ile Gly Pro Phe Ile 
        115                 120                 125             


Ala Arg Leu Lys Lys Lys Ile Gln Ala Ile Gly Gly Thr Leu Phe Val 
    130                 135                 140                 


Asn Pro Asp Gly His Glu Trp Leu Arg Ala Lys Trp Ser Leu Pro Val 
145                 150                 155                 160 


Arg Lys Tyr Trp Lys Phe Ser Glu Gln Leu Met Val Lys Tyr Ala Asp 
                165                 170                 175     


Leu Leu Val Cys Asp Ser Lys Asn Ile Glu Lys Tyr Ile Gln Asn Asp 
            180                 185                 190         


Tyr Lys Gln Tyr Gln Pro Lys Thr Thr Tyr Ile Ala Tyr Gly Thr Asp 
        195                 200                 205             


Thr Ser Pro Ser Ile Leu Lys Ser Glu Asp Leu Lys Ile Arg Ser Trp 
    210                 215                 220                 


Tyr Gln Glu Lys Gly Leu Ser Glu Asn Gly Tyr Tyr Leu Val Val Gly 
225                 230                 235                 240 


Arg Phe Val Pro Glu Asn Asn Tyr Glu Thr Met Ile Arg Glu Phe Ile 
                245                 250                 255     


Lys Ser Lys Ser Lys Lys Asp Phe Val Leu Ile Thr Asn Val Glu Gln 
            260                 265                 270         


Asn Lys Phe Tyr Asp Gln Leu Leu Gln Glu Thr Gly Phe Asp Lys Asp 
        275                 280                 285             


Pro Arg Val Lys Phe Val Gly Thr Val Tyr Asp Gln Glu Leu Leu Lys 
    290                 295                 300                 


Tyr Ile Arg Glu Asn Ala Phe Ala Tyr Phe His Gly His Glu Val Gly 
305                 310                 315                 320 


Gly Thr Asn Pro Ser Leu Leu Glu Ala Leu Ala Ser Thr Lys Leu Asn 
                325                 330                 335     


Leu Leu Leu Asp Val Gly Phe Asn Arg Glu Val Gly Glu Asp Gly Ala 
            340                 345                 350         


Ile Tyr Trp Arg Lys Asp Asn Leu His Lys Val Ile Glu Glu Ser Glu 
        355                 360                 365             


Gln Lys Thr Ile Glu Glu Ile Lys Glu Ile Asp Ile Leu Ser Thr Glu 
    370                 375                 380                 


Gln Val Glu Lys Arg Phe Thr Trp Asp Phe Ile Val Asn Glu Tyr Glu 
385                 390                 395                 400 


Asn Leu Phe Leu Leu Gly Lys 
                405         


<210>  29
<211>  395
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  29

Met Thr Ile Lys Ile Asn Tyr Met Phe Phe Val Cys Leu Ser Phe Phe 
1               5                   10                  15      


Gly Ile Val Leu Ser Ser Ser Gln Val Ile Val Asn Leu Gly Leu Ser 
            20                  25                  30          


Ser Ile Val Gln Tyr Ile Ala Tyr Phe Leu Leu Leu Leu Cys Ile Phe 
        35                  40                  45              


Phe Thr Leu Ile Lys Asn Ser Pro Asp Val Ile Ala Asn Arg Ile Ala 
    50                  55                  60                  


Tyr Phe Ser Ile Ile Ser Phe Leu Phe Ile Ile Gly Ile Asn Leu Gln 
65                  70                  75                  80  


Asn Leu Pro Phe Ser Thr Lys Ile Tyr Leu Ser Phe Ser Met Leu Ile 
                85                  90                  95      


Ile Ser Ser Leu Ser Thr Leu Pro Ile Lys Leu Ile Asn Asn Ile Asn 
            100                 105                 110         


Asp Phe Arg Arg Ile Ser Tyr Phe Leu Leu Asn Gly Ile Leu Leu Ser 
        115                 120                 125             


Thr Phe Leu Gly Trp Leu Phe Asn Ile Ser Leu Val Thr Val Ala Val 
    130                 135                 140                 


Glu Gly Ile Gly Phe Ala Tyr Gly Phe Asn Gly Gly Leu Thr His Lys 
145                 150                 155                 160 


Asn Phe Tyr Ala Ile Thr Ile Leu Val Ser Tyr Ile Leu Leu Phe Ile 
                165                 170                 175     


Ser Arg Lys His Gly Thr Lys Tyr Gln Val Asp Ser Leu Val Leu Trp 
            180                 185                 190         


Phe Asp Leu Phe Leu Leu Leu Val Ser Asn Thr Arg Thr Ile Tyr Ile 
        195                 200                 205             


Ile Leu Val Val Phe Trp Ile Val Val His Ser Gly Phe Ile Lys Tyr 
    210                 215                 220                 


Ile Lys Lys Asn His Arg Pro Val Ile Ile Thr Thr Trp Leu Val Ile 
225                 230                 235                 240 


Ser Leu Leu Ser Ile Ile Phe Phe Phe Lys His Ile Ile Asn Asn Ser 
                245                 250                 255     


Glu Ser Tyr Thr His Arg Val Leu Gly Ile Val Asn Phe Phe Lys Tyr 
            260                 265                 270         


Tyr Glu Ser Ser Lys Phe His Leu Phe Phe Gly Asp Ala Glu Leu Ala 
        275                 280                 285             


Phe Gly Asp Met Thr Lys Gly Tyr Thr His Asn Ile Arg Ser Val Leu 
    290                 295                 300                 


Gly Trp Asp Gly Thr Val Glu Met Pro Leu Leu Ser Val Met Ile Lys 
305                 310                 315                 320 


Asn Gly Tyr Val Gly Leu Ile Gly Tyr Gly Val Val Leu Phe Lys Phe 
                325                 330                 335     


Ile Ser Ser Val Leu Ser Met Glu Asp Arg Arg Val Lys Asn Ile Gly 
            340                 345                 350         


Leu Ser Ile Leu Ile Pro Leu Leu Leu Ser Ala Met Val Glu Asn Tyr 
        355                 360                 365             


Ile Val Asn Ile Ser Phe Val Phe Met Pro Val Cys Phe Cys Ile Leu 
    370                 375                 380                 


Cys Ser Ile Lys Asn Ile Glu Phe Lys Asn Asn 
385                 390                 395 


<210>  30
<211>  322
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  30

Met Lys Lys Val Ser Ile Ile Leu Pro Val Tyr Asn Val Glu Gln Tyr 
1               5                   10                  15      


Ile Lys Lys Cys Leu Glu Ser Ile Gln Gln Gln Thr Tyr Pro Asn Leu 
            20                  25                  30          


Glu Val Ile Ile Val Asn Asp Gly Ala Thr Asp Lys Ser Val Glu Tyr 
        35                  40                  45              


Cys Glu Gln Ile Cys Lys Ile Asp Ser Arg Phe Ser Val Thr His Lys 
    50                  55                  60                  


Glu Asn Gly Gly Leu Ser Asp Ala Arg Asn Val Gly Ile Asp Lys Ala 
65                  70                  75                  80  


Lys Gly Asp Tyr Leu Ile Phe Val Asp Ser Asp Asp Phe Val Ser Gln 
                85                  90                  95      


Asp Met Val Ser Tyr Leu Val Ser Ser Met Glu Asn Asn Glu Ala Asp 
            100                 105                 110         


Ile Ala Ile Cys Asp Pro Ala His Tyr Tyr Ser Asp Arg Gln Asn Asn 
        115                 120                 125             


Asp Leu Asn Ile Phe Tyr Pro Ala Ser Ser Val Lys Val Tyr Glu Lys 
    130                 135                 140                 


Thr Glu Ala Leu Cys Glu Met Phe Tyr Gln Lys Ser Phe Leu Val Ser 
145                 150                 155                 160 


Ala Trp Ala Lys Ile Tyr Lys Lys Glu Leu Phe Asp Asp Ile Arg Phe 
                165                 170                 175     


Pro Val Gly Lys Leu Phe Glu Asp Ser Ala Val Met Tyr Leu Leu Phe 
            180                 185                 190         


Glu Lys Cys Glu Lys Ile Val Tyr Ser Asn Ala Lys Leu Tyr Ala Tyr 
        195                 200                 205             


Val His Arg Asp Asn Ser Ile Thr Thr Lys Lys Phe Ser Asp Lys Asp 
    210                 215                 220                 


Leu Asp Ile Leu Asp Ile Ser Asn Thr Ile Leu Asp His Tyr Ser Gly 
225                 230                 235                 240 


Asn Phe Arg Val Tyr Lys Ala Ala Val Ser Tyr Lys Val Ser Ala Cys 
                245                 250                 255     


Phe Arg Ile Leu Leu Asn Ser Ser Ser Glu Lys Lys Tyr Asn Gln Ile 
            260                 265                 270         


Gln Lys Asp Cys Met Thr Tyr Ile Leu Arg Asn Trp Arg Asn Met Leu 
        275                 280                 285             


Phe Asp Lys Asn Val Arg Leu Lys Asn Lys Leu Ala Leu Ile Ser Ile 
    290                 295                 300                 


Thr Leu Phe Asn Pro Phe Val Lys Phe Ile Tyr Ser Lys Val Asn Arg 
305                 310                 315                 320 


Trp Glu 
        


<210>  31
<211>  412
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  31

Met Asn Lys Tyr Glu Glu Arg Tyr Gln Glu Asp Leu Ser Lys Asn Asp 
1               5                   10                  15      


Phe Glu Lys Leu Ile Asn Arg Arg Tyr Leu Ser Asp Lys Glu Leu Gln 
            20                  25                  30          


Val Glu Tyr Val Lys Lys Gly Thr Val Leu Pro Pro Lys Val Phe Glu 
        35                  40                  45              


Met Lys Leu Ser Asn Lys Leu Gly Leu Gln Lys Ala Leu His Gly Lys 
    50                  55                  60                  


Gly Gly Val Val Asp Ser Lys Gly Asn Tyr Val Glu Leu Ser Glu Gln 
65                  70                  75                  80  


Lys Ala Val Gly Met Arg Asn Arg Val Tyr Gly Ser Tyr Lys Phe Asn 
                85                  90                  95      


His Lys Asn Leu Ala Ile Arg Asn Glu Lys Val Ile Tyr Leu Asn Tyr 
            100                 105                 110         


Phe Ile Asn Gln Trp Gly His Phe Leu Leu Asp Val Val Gly Arg Leu 
        115                 120                 125             


Trp Tyr Pro Leu Leu Lys Asp Thr Asp Thr Lys Leu Asp Tyr Thr Cys 
    130                 135                 140                 


Tyr Ala Gly Thr Glu Thr Lys Leu Glu Gly Asn Tyr Leu Glu Phe Leu 
145                 150                 155                 160 


Glu Leu Leu Gly Ile Asp Lys Ser Arg Leu Ile Leu Ile Asn Arg Pro 
                165                 170                 175     


Thr Gln Phe Ser Glu Ile Ile Ile Pro Glu Ser Ser Ile Leu Pro Gly 
            180                 185                 190         


Glu Tyr Tyr Thr Lys Glu Tyr Lys Met Leu Phe Asn Ser Leu Val Ala 
        195                 200                 205             


Asn Val Lys Leu Asp Asn Asn Leu Glu Ser Lys Lys Ile Tyr Cys Ser 
    210                 215                 220                 


Arg Ala Arg Leu Asp Leu Ala Lys Gly Lys Glu Phe Gly Glu Asn Gly 
225                 230                 235                 240 


Ile Glu Lys Val Phe Leu Lys Asn Gly Tyr Thr Pro Val Tyr Met Glu 
                245                 250                 255     


Thr Met Ser Leu Lys Glu Gln Ile Arg Thr Leu Leu Ser Ala Thr Thr 
            260                 265                 270         


Ile Val Leu Thr Ser Gly Ser Leu Ala His Asn Leu Leu Phe Ile Asn 
        275                 280                 285             


Asn Lys Ile Asn Val Phe Ile Leu Asn Lys Thr Tyr Arg Val Asn Leu 
    290                 295                 300                 


His Gln Phe Leu Ile Asn Lys Ile Ser Glu Ala Ser Val Ser Phe Val 
305                 310                 315                 320 


Asp Ile Tyr Arg Ser Pro Leu Pro Ile Leu Tyr Gly Tyr Gly Pro Phe 
                325                 330                 335     


Leu Met Asp Ile Thr Lys Pro Leu Val Asn Phe Phe Glu Asp Ser Gly 
            340                 345                 350         


Phe Thr Tyr Asp Ser Gly Thr Ile Leu Asp Lys Thr Asp Tyr Phe Lys 
        355                 360                 365             


Phe Tyr Leu Lys Trp Leu Trp Ser Tyr Lys Phe Phe Leu Phe Arg Leu 
    370                 375                 380                 


Asn His Ile Lys Glu Gly Asn Ser Glu Phe Glu Lys Ser Phe Lys Ile 
385                 390                 395                 400 


Ile Arg Arg Tyr Tyr Lys Met Gly Arg Gln Tyr Glu 
                405                 410         


<210>  32
<211>  462
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  32

Met Ser Lys Tyr Lys Glu Leu Ala Lys Asn Thr Gly Thr Phe Ala Leu 
1               5                   10                  15      


Ala Asn Phe Ser Ser Lys Ile Leu Ile Phe Leu Leu Val Pro Ile Tyr 
            20                  25                  30          


Thr Lys Val Leu Thr Thr Thr Glu Tyr Gly Phe Tyr Asp Leu Val Tyr 
        35                  40                  45              


Thr Thr Ile Gln Leu Leu Val Pro Ile Leu Thr Leu Asn Ile Ser Glu 
    50                  55                  60                  


Ala Val Met Arg Phe Leu Met Lys Glu Asp Val Ser Lys Lys Ser Val 
65                  70                  75                  80  


Phe Ser Ile Ala Ile Leu Asp Ile Phe Leu Gly Ser Ile Ile Phe Cys 
                85                  90                  95      


Leu Leu Leu Leu Val Asn Gln Ile Phe Ser Leu Ser Glu Leu Ile Ser 
            100                 105                 110         


Gln Tyr Ser Ile Tyr Ile Met Ala Ile Phe Ala Phe Tyr Thr Leu Asn 
        115                 120                 125             


Asn Phe Leu Ile Gln Tyr Ser Lys Gly Ile Asp Lys Ile Gly Val Thr 
    130                 135                 140                 


Ala Ile Ser Gly Val Ile Ser Ala Ala Val Met Leu Ser Met Asn Ile 
145                 150                 155                 160 


Leu Leu Leu Val Val Leu Asn Trp Gly Leu Leu Gly Phe Phe Ile Ala 
                165                 170                 175     


Asn Ile Cys Gly Tyr Val Ile Pro Cys Val Tyr Ile Ile Val Lys Leu 
            180                 185                 190         


Lys Leu Trp Asp Leu Phe Glu Leu Lys Ile Asp Arg Ser Leu Gln Trp 
        195                 200                 205             


Glu Met Ile Tyr Tyr Thr Leu Pro Leu Ile Leu Asn Thr Leu Ser Trp 
    210                 215                 220                 


Trp Val Asn Asn Thr Ser Asp Arg Tyr Ile Ile Thr Val Ile Ile Gly 
225                 230                 235                 240 


Ile Gln Ala Ser Ala Ile Ile Ser Val Ala Tyr Lys Ile Pro Gln Ile 
                245                 250                 255     


Phe Ser Thr Ile Ser Ala Ile Phe Ile Gln Ser Trp Gln Ile Ser Ala 
            260                 265                 270         


Ile Lys Ile Gln Glu Glu Lys Glu Gly Asn Thr Phe Ile Ser Lys Met 
        275                 280                 285             


Leu Leu Tyr Tyr Asn Ala Leu Leu Leu Ile Ile Ala Ser Gly Ile Ile 
    290                 295                 300                 


Leu Phe Val Lys Pro Ile Ser Asn Ile Leu Phe Gly Ala Ser Phe Tyr 
305                 310                 315                 320 


Ser Ala Trp Thr Leu Val Pro Phe Leu Ile Ile Ser Ser Leu Phe Asn 
                325                 330                 335     


Ala Ile Ser Gly Tyr Ile Gly Ala Ile Met Gly Ala Lys Met Asp Thr 
            340                 345                 350         


Lys Asn Ile Ala Lys Ser Ala Leu Val Gly Met Ile Ala Asn Val Phe 
        355                 360                 365             


Leu Asn Ile Val Leu Thr Phe Leu Met Gly Leu Gln Gly Ile Thr Ile 
    370                 375                 380                 


Ser Thr Met Ile Ala Ser Phe Leu Ile Phe Tyr Met Arg Lys Asp Ser 
385                 390                 395                 400 


Val Glu Glu Ile Ala Pro Glu Thr Tyr Arg Ala Ile Tyr Leu Ser Trp 
                405                 410                 415     


Phe Leu Leu Val Val Glu Ala Ser Leu Leu Val Tyr Ile Asp Phe Ile 
            420                 425                 430         


Ile Gly Ala Thr Leu Val Thr Leu Ile Asn Leu Phe Leu Leu Lys Asp 
        435                 440                 445             


Thr Leu Lys Pro Leu Cys Leu Lys Leu Leu Lys Gly Phe Lys 
    450                 455                 460         


<210>  33
<211>  384
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  33

Met Lys Met Asn Ile Leu Gln Tyr Ile Lys Ile Leu Ala Arg Thr Ile 
1               5                   10                  15      


Phe Met Leu Leu Ile Ser Thr Val Leu Leu Pro Val Arg Leu Lys Asn 
            20                  25                  30          


Asn Lys Ile Leu Phe Ile Asn Phe Asn Gly Lys Gly Tyr Gly Asp Asn 
        35                  40                  45              


Pro Lys Ser Ile Cys Glu Tyr Leu Arg Thr Thr Tyr Pro Asp Leu Asp 
    50                  55                  60                  


Leu Val Trp Leu Ala Arg Asp Asn Glu Gly Phe Pro Asp Gly Val Arg 
65                  70                  75                  80  


Val Val Lys Tyr Gly Thr Phe Gln Ala Phe Tyr Glu Gln Ala Ser Ser 
                85                  90                  95      


Lys Val Trp Val Tyr Asn Val Arg Ala Phe Ala Arg Ile Leu Lys Lys 
            100                 105                 110         


Arg Gly Gln Ile Tyr Ile Gln Thr Trp His Gly Ala Ser Ser Phe Lys 
        115                 120                 125             


Leu Ile Glu Lys Gln Ala Asp Leu Pro Ile Asn Tyr Val Leu Glu Ala 
    130                 135                 140                 


Lys Tyr Asp Ala Arg Val Thr Asp Ile Met Ile Ser Asp Ser Arg Lys 
145                 150                 155                 160 


Gln Thr Glu Glu Phe Gln Lys Tyr Phe Trp Tyr Ser Gly Glu Ile Phe 
                165                 170                 175     


Glu Val Gly Met Pro Arg Asn Asp Ala Leu Phe His Tyr Lys Glu Asp 
            180                 185                 190         


Tyr Asp Lys Leu Asn Asn Ile Arg Lys Glu Leu Ser Ile His Ser Asp 
        195                 200                 205             


Asp Tyr Val Ile Leu Tyr Ala Pro Thr Phe Arg Asp Asp Gly Asp Ala 
    210                 215                 220                 


Ser Tyr Leu Asp Ile Asn Phe Glu Arg Leu Leu Gln Cys Val Glu His 
225                 230                 235                 240 


Gly Ile Lys Lys Lys Cys Lys Phe Leu Ile Arg Leu His Pro Asn His 
                245                 250                 255     


Ser His Leu Cys Asn Asn Ile Ser Phe Asn Lys Asn Ile Ile Asn Ala 
            260                 265                 270         


Thr Phe Tyr Ser Asp Met Gln Glu Leu Thr Leu Leu Ala Asp Val Leu 
        275                 280                 285             


Val Thr Asp Tyr Ser Ser Ser Ile Phe Asp Phe Met Leu Leu Asn Lys 
    290                 295                 300                 


Pro Tyr Val Arg Tyr Val Asn Asp Leu Glu Lys Tyr Ala Glu Leu Arg 
305                 310                 315                 320 


Gly Val Ser Asp Thr Tyr Tyr Glu Leu Pro Asp Ser Ile Ile Lys Thr 
                325                 330                 335     


Ala Glu Glu Leu Tyr Asp Leu Leu Pro Lys Lys Ile Glu Asn Phe Asp 
            340                 345                 350         


Tyr Asp Ser Ile Lys Lys Tyr Arg Asn Glu Ile Leu Cys Pro Ile Phe 
        355                 360                 365             


Asn Gly Thr Ala Ser Glu Asn Val Gly Arg Arg Ile Ile Gln Glu Leu 
    370                 375                 380                 


<210>  34
<211>  342
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  34

Met Lys Asn Asn Asp Leu Lys Ile Gly Ser Gly Ala Ile His Gln Ile 
1               5                   10                  15      


Ser Ala Thr Leu Ser Gln Asn Ser Ile Ser Gly Lys Ile Leu Tyr Cys 
            20                  25                  30          


Ala Asp Pro Val Val Asp Asp Leu Tyr Gly Ser Ile Val Arg Ser Gln 
        35                  40                  45              


Ile Glu Glu Ile Gly Arg Val Lys Glu Glu Ser Cys Asn Tyr Asn Thr 
    50                  55                  60                  


Ile Ala Tyr Ala Met Asn Ile Ala Glu Arg Ala Ile Ala Thr Asp Ile 
65                  70                  75                  80  


Asp Cys Ile Val Gly Met Gly Gly Gly Arg Val Leu Asp Val Cys Lys 
                85                  90                  95      


Tyr Ala Ser Phe Ile Ser Lys Arg Pro Tyr Leu Ser Ile Pro Thr Thr 
            100                 105                 110         


Ala Ala Asn Asp Gly Ile Ala Ser Pro Val Ala Val Leu Lys Arg Gln 
        115                 120                 125             


Asp Asp Arg Pro Lys Ser Leu Gly Ala Ala Ile Pro Ser Met Thr Leu 
    130                 135                 140                 


Ile Asp Ile Asp Val Ile Ala Ser Gly Pro Ile Gln Asn Ile Lys Ala 
145                 150                 155                 160 


Gly Ile Gly Asp Thr Ile Ser Asn Tyr Thr Ala Leu Lys Asp Trp Glu 
                165                 170                 175     


Leu Ala Val Glu Arg Gly Lys Asp Glu Met His Gly Phe Ala Tyr Leu 
            180                 185                 190         


Met Ser Gln Asn Ser Leu Asp Ala Leu Met Lys Thr Lys Tyr Asn Ser 
        195                 200                 205             


Ile Thr Pro Asp Phe Ile Glu Val Leu Val Asn Ser Leu Val Leu Ser 
    210                 215                 220                 


Gly Ile Ala Met Asp Phe Ala Gly Ser Ser Arg Pro Val Ser Gly Ser 
225                 230                 235                 240 


Glu His Leu Phe Ser His Ala Leu Asp Tyr Tyr Gly Ser Thr Arg Asn 
                245                 250                 255     


Leu His Gly Ile Gln Val Ala Leu Gly Thr Val Ala Val Leu Lys Leu 
            260                 265                 270         


Ile Glu Asn Ser Val Asp Thr Val Val Asp Tyr Leu Gln Arg Phe Glu 
        275                 280                 285             


Val His Ile Asn Pro Lys Leu Leu Gly Ile Asp Glu Glu Leu Phe Ile 
    290                 295                 300                 


Tyr Cys Met Gln His Ala Thr Lys Met Arg Ser Asn Arg Tyr Thr Tyr 
305                 310                 315                 320 


Leu His Glu Val Asp Leu Ser Thr Asp Arg Leu Lys Gln Ile Tyr Lys 
                325                 330                 335     


Glu Leu Ile Ser Glu Leu 
            340         


<210>  35
<211>  234
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  35

Met Lys Ala Leu Ile Leu Ala Ala Gly Leu Gly Thr Arg Leu Ala Pro 
1               5                   10                  15      


Ile Thr Asn Glu Val Pro Lys Ser Leu Val Pro Val Asn Gly Lys Pro 
            20                  25                  30          


Ile Leu Met Lys Gln Ile Glu Asn Leu Tyr Gln Asn Asn Ile Thr Asp 
        35                  40                  45              


Ile Thr Ile Ile Ala Gly Tyr Lys Ser Ser Val Leu Thr Asp Ala Val 
    50                  55                  60                  


Thr Glu Lys Tyr Pro Glu Ile Asn Ile Ile Asp Asn Val Asp Phe Lys 
65                  70                  75                  80  


Thr Thr Asn Asn Met Tyr Ser Ala Tyr Leu Gly Lys Ala Ala Met Gly 
                85                  90                  95      


Asp Ser Asp Phe Leu Met Met Asn Ala Asp Val Phe Tyr Asp Ala Ser 
            100                 105                 110         


Val Ile Lys Ser Leu Leu Leu His Lys Ala Pro Asn Ala Ile Val Thr 
        115                 120                 125             


Asp Leu Gly Ile Tyr Ile Glu Glu Ser Met Lys Val Val Glu Lys Asn 
    130                 135                 140                 


Gly Arg Leu Val Glu Ile Ser Lys Gln Ile Ser Pro Glu Glu Thr Leu 
145                 150                 155                 160 


Gly Ala Ser Ile Asp Val Tyr Lys Phe Ser Tyr Glu Ala Gly Ala Arg 
                165                 170                 175     


Phe Phe Glu Lys Cys Lys Glu Phe Ile Glu Asp Lys Arg Glu Leu Gln 
            180                 185                 190         


Met Trp Ser Glu Val Ala Leu Asn Ala Ile Leu Ser Glu Val Glu Phe 
        195                 200                 205             


Val Ala Cys Pro Leu Glu Gly Arg Trp Leu Glu Ile Asp Asn His Glu 
    210                 215                 220                 


Asp Leu Val Ala Ala Glu Lys Leu Phe Ala 
225                 230                 


<210>  36
<211>  283
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  36

Met Asn Arg Ile Arg Arg Met Lys Leu Thr Asn Arg Val Asp Tyr Phe 
1               5                   10                  15      


Gly Ala Asp Ile Ser Glu Leu Gln Asn Lys Lys Leu Phe Leu Phe Asp 
            20                  25                  30          


Met Asp Gly Thr Ile Tyr Glu Glu Asp Arg Leu Phe Glu Gly Thr Leu 
        35                  40                  45              


Glu Leu Leu Asp Tyr Ile His Asn Ile Gly Gly Glu Tyr Ile Phe Ile 
    50                  55                  60                  


Thr Asn Asn Ser Ser Lys Ser Val Val Asp Tyr Val Glu Lys Val Asn 
65                  70                  75                  80  


Arg Leu Gly Ile Lys Ala Glu Arg Asp Asn Phe Phe Thr Ser Ala Gln 
                85                  90                  95      


Ala Thr Ile Val Tyr Ile Lys Glu Asn Tyr Pro Lys Ser Lys Val Tyr 
            100                 105                 110         


Cys Gln Gly Thr Lys Ser Leu Ile Lys Glu Leu Ser Asp Ala Gly Ile 
        115                 120                 125             


Asp Val Thr Glu Gln Val Ser Ala Asp Ile Asp Val Val Leu Val Gly 
    130                 135                 140                 


Phe Asp Thr Glu Leu Thr Ser Asp Lys Ile Arg Asn Thr Cys Glu Ile 
145                 150                 155                 160 


Leu Ser Thr Lys Asp Val Pro Phe Ile Ala Thr Asn Pro Asp Ile Arg 
                165                 170                 175     


Cys Pro Val Ser Phe Gly Phe Ile Pro Asp Cys Gly Ser Ile Cys Asp 
            180                 185                 190         


Met Ile Ser Lys Ser Val Asp Arg Lys Pro Val Tyr Ile Gly Lys Pro 
        195                 200                 205             


Glu Pro Thr Met Val Asp Ile Val Arg Lys Lys Leu Asn Tyr Ser Leu 
    210                 215                 220                 


Phe Glu Thr Val Val Ile Gly Asp Arg Leu Tyr Thr Asp Ile Met Thr 
225                 230                 235                 240 


Gly Ile Asn Ala Gly Val Thr Ser Val Cys Val Leu Thr Gly Glu Ala 
                245                 250                 255     


Thr Val Asn Asp Ile Gln Gln Asp Ser Ile Lys Pro Thr Tyr Thr Phe 
            260                 265                 270         


Lys Asn Val Lys Glu Met Trp Lys Gly Ile Val 
        275                 280             


<210>  37
<211>  289
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  37

Met Lys Gly Ile Ile Leu Ala Gly Gly Ser Gly Thr Arg Leu Tyr Pro 
1               5                   10                  15      


Leu Thr Arg Ala Ala Ser Lys Gln Leu Met Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Thr Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Leu Ile Ile Ser Thr Pro Gln Asp Leu Pro Arg Phe Lys Glu Leu 
    50                  55                  60                  


Leu Gln Asp Gly Ser Glu Phe Gly Ile Lys Leu Ser Tyr Ala Glu Gln 
65                  70                  75                  80  


Pro Ser Pro Asp Gly Leu Ala Gln Ala Phe Ile Ile Gly Glu Glu Phe 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Ile Leu Gly Asp Asn Ile Tyr His 
            100                 105                 110         


Gly Pro Gly Leu Ser Thr Met Leu Gln Lys Ala Ala Lys Lys Glu Lys 
        115                 120                 125             


Gly Ala Thr Val Phe Gly Tyr His Val Lys Asp Pro Glu Arg Phe Gly 
    130                 135                 140                 


Val Val Glu Phe Asp Glu Asn Met Asn Ala Ile Ser Ile Glu Glu Lys 
145                 150                 155                 160 


Pro Glu Tyr Pro Arg Ser Asn Tyr Ala Val Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Glu Ile Ala Lys Ser Ile Lys Pro Ser Pro Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Lys Ala Tyr Leu Asp Arg Gly 
        195                 200                 205             


Asp Leu Ser Val Glu Leu Met Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Glu Ser Leu Leu Glu Ala Ser Gln Tyr Ile Glu Thr Val 
225                 230                 235                 240 


Gln Arg Met Gln Asn Val Gln Val Ala Asn Leu Glu Glu Ile Ala Tyr 
                245                 250                 255     


Arg Met Gly Tyr Ile Ser Arg Glu Asp Val Leu Ala Leu Ala Gln Pro 
            260                 265                 270         


Leu Lys Lys Asn Glu Tyr Gly Gln Tyr Leu Leu Arg Leu Ile Gly Glu 
        275                 280                 285             


Ala 
    


<210>  38
<211>  197
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  38

Met Thr Asp Asn Phe Phe Gly Lys Thr Leu Ala Ala Arg Lys Val Glu 
1               5                   10                  15      


Ala Ile Pro Gly Met Leu Glu Phe Asp Ile Pro Val His Gly Asp Asn 
            20                  25                  30          


Arg Gly Trp Phe Lys Glu Asn Phe Gln Lys Glu Lys Met Leu Pro Leu 
        35                  40                  45              


Gly Phe Pro Glu Ser Phe Phe Ala Glu Gly Lys Leu Gln Asn Asn Val 
    50                  55                  60                  


Ser Phe Ser Arg Lys Asn Val Leu Arg Gly Leu His Ala Glu Pro Trp 
65                  70                  75                  80  


Asp Lys Tyr Ile Ser Val Ala Asp Gly Gly Lys Val Leu Gly Ser Trp 
                85                  90                  95      


Val Asp Leu Arg Glu Gly Glu Thr Phe Gly Asn Thr Tyr Gln Thr Val 
            100                 105                 110         


Ile Asp Ala Ser Lys Gly Ile Phe Val Pro Arg Gly Val Ala Asn Gly 
        115                 120                 125             


Phe Gln Val Leu Ser Asp Thr Val Ser Tyr Ser Tyr Leu Val Asn Asp 
    130                 135                 140                 


Tyr Trp Ala Leu Glu Leu Lys Pro Lys Tyr Ala Phe Val Asn Tyr Ala 
145                 150                 155                 160 


Asp Pro Ser Leu Gly Ile Glu Trp Glu Asn Ile Ala Glu Ala Glu Val 
                165                 170                 175     


Ser Glu Ala Asp Lys Asn His Pro Leu Leu Lys Asp Val Lys Pro Leu 
            180                 185                 190         


Lys Lys Glu Asp Leu 
        195         


<210>  39
<211>  349
<212>  PRT
<213>  Streptococcus pneumoniae (

<400>  39

Met Thr Glu Tyr Lys Asn Ile Ile Val Thr Gly Gly Ala Gly Phe Ile 
1               5                   10                  15      


Gly Ser Asn Phe Val His Tyr Val Tyr Glu Asn Phe Pro Gly Val His 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Ala Asn Ile 
        35                  40                  45              


Glu Glu Ile Leu Gly Asn Arg Val Glu Leu Val Val Gly Asp Ile Ala 
    50                  55                  60                  


Asp Ala Glu Leu Val Asp Lys Leu Ala Ala Gln Ala Asp Ala Ile Val 
65                  70                  75                  80  


His Tyr Ala Ala Glu Ser His Asn Asp Asn Ser Leu Asn Asp Pro Ser 
                85                  90                  95      


Pro Phe Ile His Thr Asn Phe Ile Gly Thr Tyr Thr Leu Leu Glu Ala 
            100                 105                 110         


Ala Arg Lys Tyr Asp Ile Arg Phe His His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Asp Leu Pro Leu Arg Glu Asp Leu Pro Gly His Gly Glu Gly 
    130                 135                 140                 


Pro Gly Glu Lys Phe Thr Ala Glu Thr Lys Tyr Asn Pro Ser Ser Pro 
145                 150                 155                 160 


Tyr Ser Ser Thr Lys Ala Ala Ser Asp Leu Ile Val Lys Ala Trp Val 
                165                 170                 175     


Arg Ser Phe Gly Val Lys Ala Thr Ile Ser Asn Cys Ser Asn Asn Tyr 
            180                 185                 190         


Gly Pro Tyr Gln His Ile Glu Lys Phe Ile Pro Arg Gln Ile Thr Asn 
        195                 200                 205             


Ile Leu Ser Gly Ile Lys Pro Lys Leu Tyr Gly Glu Gly Lys Asn Val 
    210                 215                 220                 


Arg Asp Trp Ile His Thr Asn Asp His Ser Ser Gly Val Trp Thr Ile 
225                 230                 235                 240 


Leu Thr Lys Gly Gln Ile Gly Glu Thr Tyr Leu Ile Gly Ala Asp Gly 
                245                 250                 255     


Glu Lys Asn Asn Lys Glu Val Leu Glu Leu Ile Leu Lys Glu Met Gly 
            260                 265                 270         


Gln Ala Thr Asp Ala Tyr Asp His Val Thr Asp Arg Ala Gly His Asp 
        275                 280                 285             


Leu Arg Tyr Ala Ile Asp Ala Ser Lys Leu Arg Asp Glu Leu Gly Trp 
    290                 295                 300                 


Lys Pro Glu Phe Thr Asn Phe Glu Ala Gly Leu Lys Ala Thr Ile Lys 
305                 310                 315                 320 


Trp Tyr Thr Asp Asn Gln Glu Trp Trp Lys Ala Glu Lys Glu Ala Val 
                325                 330                 335     


Glu Ala Asn Tyr Ala Lys Thr Gln Glu Ile Ile Thr Val 
            340                 345                 


<210>  40
<211>  283
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  40

Met Ile Leu Ile Thr Gly Ala Asn Gly Gln Leu Gly Thr Glu Leu Arg 
1               5                   10                  15      


Tyr Leu Leu Asp Glu Arg Asn Glu Glu Tyr Val Ala Val Asp Val Ala 
            20                  25                  30          


Glu Met Asp Ile Thr Asn Glu Glu Met Val Glu Lys Val Phe Glu Glu 
        35                  40                  45              


Val Lys Pro Thr Leu Val Tyr His Cys Ala Ala Tyr Thr Ala Val Asp 
    50                  55                  60                  


Ala Ala Glu Asp Glu Gly Lys Glu Leu Asn Phe Ala Ile Asn Val Thr 
65                  70                  75                  80  


Gly Thr Lys Asn Val Ala Lys Ala Ser Glu Lys His Gly Ala Thr Leu 
                85                  90                  95      


Val Tyr Ile Ser Thr Asp Tyr Val Phe Asp Gly Lys Lys Pro Val Gly 
            100                 105                 110         


Gln Glu Trp Glu Val Asp Asp Arg Pro Asp Pro Gln Thr Glu Tyr Gly 
        115                 120                 125             


Arg Thr Lys Arg Met Gly Glu Glu Leu Val Glu Lys His Val Ser Asn 
    130                 135                 140                 


Phe Tyr Ile Ile Arg Thr Ala Trp Val Phe Gly Asn Tyr Gly Lys Asn 
145                 150                 155                 160 


Phe Val Phe Thr Met Gln Asn Leu Ala Lys Thr His Lys Thr Leu Thr 
                165                 170                 175     


Val Val Asn Asp Gln Tyr Gly Arg Pro Thr Trp Thr Arg Thr Leu Ala 
            180                 185                 190         


Glu Phe Met Thr Tyr Leu Ala Glu Asn Arg Lys Glu Phe Gly Tyr Tyr 
        195                 200                 205             


His Leu Ser Asn Asp Ala Thr Glu Asp Thr Thr Trp Tyr Asp Phe Ala 
    210                 215                 220                 


Val Glu Ile Leu Lys Asp Thr Asp Val Glu Val Lys Pro Val Asp Ser 
225                 230                 235                 240 


Ser Gln Phe Pro Ala Lys Ala Lys Arg Pro Leu Asn Ser Thr Met Ser 
                245                 250                 255     


Leu Ala Lys Ala Lys Ala Thr Gly Phe Val Ile Pro Thr Trp Gln Asp 
            260                 265                 270         


Ala Leu Gln Glu Phe Tyr Lys Gln Glu Val Arg 
        275                 280             


<210>  41
<211>  481
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  41

Met Ser Arg Arg Phe Lys Lys Ser Arg Ser Gln Lys Val Lys Arg Ser 
1               5                   10                  15      


Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val Cys Phe Leu 
            20                  25                  30          


Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg Tyr Leu Asn 
        35                  40                  45              


Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val Gly Leu Leu 
    50                  55                  60                  


Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe Leu Leu Val 
65                  70                  75                  80  


Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val Gln Gln Phe 
                85                  90                  95      


Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr Ser Glu Tyr 
            100                 105                 110         


Ser Ile Ser Val Ala Val Leu Ala Asp Ser Asp Ile Glu Asn Val Thr 
        115                 120                 125             


Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asp Asn Glu Asn Ile 
    130                 135                 140                 


Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr Asp Leu Thr 
145                 150                 155                 160 


Val Asp Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser Leu Ile Ala 
                165                 170                 175     


Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu Asn Ile Ile 
            180                 185                 190         


Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys Ile Tyr Thr 
        195                 200                 205             


Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser Lys Asn Gln 
    210                 215                 220                 


Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly Pro Ile Ser 
225                 230                 235                 240 


Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val Asn Arg Asp 
                245                 250                 255     


Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala Tyr Val Pro 
            260                 265                 270         


Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr His Ala Gly 
        275                 280                 285             


Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn Leu Tyr Gly 
    290                 295                 300                 


Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser Phe Leu Lys 
305                 310                 315                 320 


Met Ile Asp Leu Leu Gly Gly Val Asp Val His Asn Asp Gln Glu Phe 
                325                 330                 335     


Ser Ala Leu His Gly Lys Phe His Phe Pro Val Gly Asn Val His Leu 
            340                 345                 350         


Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr Ser Leu Ala 
        355                 360                 365             


Asp Gly Asp Arg Asp Arg Gly Arg Asn Gln Gln Lys Val Ile Val Ala 
    370                 375                 380                 


Ile Leu Gln Lys Leu Thr Ser Thr Glu Ala Leu Lys Asn Tyr Ser Thr 
385                 390                 395                 400 


Ile Ile Asp Ser Leu Gln Asp Ser Ile Gln Thr Asn Met Pro Leu Glu 
                405                 410                 415     


Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly Gly Asn Tyr 
            420                 425                 430         


Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Thr Asp Leu Pro 
        435                 440                 445             


Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Met Glu Ile Asp Asp 
    450                 455                 460                 


Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val Met Glu Gly 
465                 470                 475                 480 


Arg 
    


<210>  42
<211>  243
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  42

Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
1               5                   10                  15      


Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Thr Glu Ser Tyr Arg Gln 
            20                  25                  30          


Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
        35                  40                  45              


Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
    50                  55                  60                  


Ile Ala Lys Glu Val Ala Asp Asp Leu Val Ile Ala Tyr Gly Ala Glu 
65                  70                  75                  80  


Ile Tyr Tyr Thr Leu Asp Ala Leu Glu Lys Leu Glu Lys Lys Glu Ile 
                85                  90                  95      


Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
            100                 105                 110         


Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 
        115                 120                 125             


Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
    130                 135                 140                 


Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 
145                 150                 155                 160 


Gln Val Asn Ser Ser His Val Leu Lys Pro Lys Leu Phe Gly Glu Arg 
                165                 170                 175     


Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Gln Asp Leu 
            180                 185                 190         


Val His Val Ile Ala Ser Asp Met His Asn Leu Asp Gly Arg Pro Pro 
        195                 200                 205             


His Met Ala Glu Ala Tyr Asp Leu Val Thr Gln Lys Tyr Gly Glu Ala 
    210                 215                 220                 


Lys Ala Gln Glu Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 
225                 230                 235                 240 


Gln Leu Ile 
            


<210>  43
<211>  231
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  43

Met Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Phe 
1               5                   10                  15      


Lys Thr Leu Trp Lys Arg Lys Leu Met Ile Leu Ile Val Ala Leu Val 
            20                  25                  30          


Thr Gly Thr Gly Ala Phe Ala Tyr Ser Thr Phe Ile Val Lys Pro Glu 
        35                  40                  45              


Tyr Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Gly Asp 
    50                  55                  60                  


Lys Pro Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val 
65                  70                  75                  80  


Lys Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asp Ala Leu Glu Lys Val 
                85                  90                  95      


Ala Thr Asn Leu Lys Leu Asp Met Pro Ala Lys Thr Leu Ala Ser Lys 
            100                 105                 110         


Val Gln Val Ala Val Pro Ala Asp Thr Arg Ile Val Ser Ile Ser Val 
        115                 120                 125             


Lys Asp Lys Gln Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg 
    130                 135                 140                 


Glu Val Ala Ala Glu Lys Ile Val Ala Val Thr Arg Val Ser Asp Val 
145                 150                 155                 160 


Thr Thr Leu Glu Glu Ala Arg Pro Ala Thr Thr Pro Ser Ser Pro Asn 
                165                 170                 175     


Val Arg Arg Asn Ser Leu Phe Gly Phe Leu Gly Gly Ala Val Val Thr 
            180                 185                 190         


Val Ile Ala Val Leu Leu Ile Glu Leu Leu Asp Thr Arg Val Lys Arg 
        195                 200                 205             


Pro Glu Asp Val Glu Asp Val Leu Lys Ile Pro Leu Leu Gly Leu Val 
    210                 215                 220                 


Pro Asp Phe Asp Lys Ile Lys 
225                 230     


<210>  44
<211>  229
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  44

Met Pro Thr Leu Glu Ile Ser Gln Ala Lys Leu Asp Ser Val Lys Lys 
1               5                   10                  15      


Ala Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Leu Gln Leu Ser Gly 
            20                  25                  30          


Asp Gly Leu Lys Val Phe Ser Ile Thr Ser Val Lys Ile Gly Glu Gly 
        35                  40                  45              


Lys Ser Thr Thr Ser Ala Asn Ile Ala Trp Ala Phe Ala Arg Ala Gly 
    50                  55                  60                  


Tyr Lys Thr Leu Leu Ile Asp Gly Asp Ile Arg Asn Ser Val Met Leu 
65                  70                  75                  80  


Gly Val Phe Lys Ala Arg Asn Lys Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      


Ser Gly Thr Thr Asp Leu Ser Gln Gly Leu Cys Asp Thr Asn Ile Glu 
            100                 105                 110         


Asn Leu Phe Val Ile Gln Ala Gly Ser Val Ser Pro Asn Pro Thr Ala 
        115                 120                 125             


Leu Leu Gln Ser Lys Asn Phe Thr Thr Met Leu Glu Thr Leu Arg Lys 
    130                 135                 140                 


Tyr Phe Asp Tyr Ile Ile Val Asp Thr Ala Pro Val Gly Val Val Ile 
145                 150                 155                 160 


Asp Ala Ala Ile Ile Thr Arg Asn Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     


Glu Ala Gly Glu Ile Asn Arg Arg Asp Ile Gln Lys Ala Lys Glu Gln 
            180                 185                 190         


Leu Glu His Thr Gly Lys Pro Phe Leu Gly Ile Val Leu Asn Lys Phe 
        195                 200                 205             


Asp Thr Ser Val Asp Lys Tyr Gly Ser Tyr Gly Asn Tyr Gly Asn Tyr 
    210                 215                 220                 


Gly Lys Asn Lys Lys 
225                 


<210>  45
<211>  455
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  45

Met Asn Glu Lys Ile Leu Arg Ser Ser Leu Ala Ile Ile Gln Ser Phe 
1               5                   10                  15      


Leu Val Ile Leu Leu Thr Tyr Leu Leu Ser Ala Val Arg Glu Thr Glu 
            20                  25                  30          


Ile Val Ser Thr Thr Ala Ile Ala Leu Cys Ile Leu His Tyr Phe Val 
        35                  40                  45              


Phe Tyr Ile Ser Asp Tyr Gly Gln Asp Phe Phe Lys Arg Arg Tyr Leu 
    50                  55                  60                  


Ile Glu Leu Val Gln Thr Leu Lys Tyr Ile Leu Phe Phe Ala Leu Ala 
65                  70                  75                  80  


Ile Gly Ile Ser Asn Phe Phe Leu Glu Asp Arg Phe Ser Ile Ser Arg 
                85                  90                  95      


Arg Gly Met Ile Tyr Phe Leu Thr Leu His Ala Leu Leu Val Tyr Val 
            100                 105                 110         


Leu Asn Leu Phe Ile Lys Trp Tyr Trp Lys Arg Ala Tyr Pro Asn Phe 
        115                 120                 125             


Lys Gly Ser Lys Lys Ile Leu Leu Leu Thr Ala Thr Ser Arg Val Glu 
    130                 135                 140                 


Lys Val Leu Asp Arg Leu Ile Glu Ser Asn Glu Val Val Gly Lys Leu 
145                 150                 155                 160 


Val Ala Val Ser Val Leu Asp Lys Pro Asp Phe Gln His Asp Cys Leu 
                165                 170                 175     


Lys Val Val Ala Glu Gly Gly Ile Val Asn Phe Ala Thr His Glu Val 
            180                 185                 190         


Val Asp Glu Val Phe Ile Asn Leu Pro Ser Glu Lys Tyr Asn Ile Gly 
        195                 200                 205             


Glu Leu Val Ser Gln Phe Glu Thr Met Gly Ile Asp Val Ile Val Asn 
    210                 215                 220                 


Leu Asn Ala Phe Asp Arg Ser Leu Ala Arg Asn Lys Gln Ile Arg Glu 
225                 230                 235                 240 


Met Ala Gly Leu Asn Val Val Thr Phe Ser Thr Thr Phe Tyr Lys Thr 
                245                 250                 255     


Ser His Val Ile Ala Lys Arg Ile Ile Asp Ile Val Gly Ala Leu Val 
            260                 265                 270         


Gly Leu Ile Leu Cys Gly Leu Val Ser Ile Val Leu Val Pro Leu Ile 
        275                 280                 285             


Arg Lys Asp Gly Gly Ser Ala Ile Phe Ala Gln Thr Arg Ile Gly Lys 
    290                 295                 300                 


Asn Gly Arg Gln Phe Thr Phe Tyr Lys Phe Arg Ser Met Cys Val Asp 
305                 310                 315                 320 


Ala Glu Ala Lys Lys Arg Glu Leu Met Glu Gln Asn Thr Met Gln Gly 
                325                 330                 335     


Gly Met Phe Lys Val Asp Asp Asp Pro Arg Ile Thr Lys Ile Gly Cys 
            340                 345                 350         


Phe Ile Arg Lys Thr Ser Leu Asp Glu Leu Pro Gln Phe Tyr Asn Val 
        355                 360                 365             


Leu Lys Gly Asp Met Ser Leu Val Gly Thr Arg Pro Pro Thr Val Asp 
    370                 375                 380                 


Glu Tyr Glu His Tyr Thr Pro Glu Gln Lys Arg Arg Leu Ser Phe Lys 
385                 390                 395                 400 


Pro Gly Ile Thr Gly Leu Trp Gln Val Ser Gly Arg Ser Glu Ile Lys 
                405                 410                 415     


Asn Phe Asp Glu Val Val Lys Leu Asp Val Ala Tyr Ile Asp Gly Trp 
            420                 425                 430         


Thr Ile Trp Lys Asp Ile Glu Ile Leu Leu Lys Thr Val Lys Val Val 
        435                 440                 445             


Phe Met Arg Asp Gly Ala Lys 
    450                 455 


<210>  46
<211>  392
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  46

Met Lys Lys Ser Val Tyr Ile Ile Gly Ser Lys Gly Ile Pro Ala Lys 
1               5                   10                  15      


Tyr Gly Gly Phe Glu Thr Phe Val Glu Lys Leu Thr Ala Phe Gln Gln 
            20                  25                  30          


Asp Lys Ala Ile Gln Tyr Tyr Val Ala Cys Met Arg Glu Asn Ser Ala 
        35                  40                  45              


Lys Ser Gly Thr Thr Glu Asp Val Phe Glu His Asn Gly Ala Ile Cys 
    50                  55                  60                  


Tyr Asn Val Asp Val Pro Asn Phe Gly Pro Ala Arg Ala Ile Ala Tyr 
65                  70                  75                  80  


Asp Ile Ala Ala Ile Asn Arg Ala Ile Glu Ile Ala Lys Glu Asn Lys 
                85                  90                  95      


Asp Glu Asp Pro Ile Phe Tyr Ile Leu Ala Cys Arg Ile Gly Pro Phe 
            100                 105                 110         


Ile His Gly Ile Lys Lys Lys Ile Gln Glu Ile Gly Gly Thr Leu Leu 
        115                 120                 125             


Val Asn Pro Asp Gly His Glu Trp Leu Arg Ala Lys Trp Ser Ala Pro 
    130                 135                 140                 


Val Arg Arg Tyr Trp Lys Ile Ser Glu Gly Leu Met Val Lys His Ala 
145                 150                 155                 160 


Asp Leu Leu Val Cys Asp Ser Lys Asn Ile Glu Lys Tyr Ile Gln Glu 
                165                 170                 175     


Asp Tyr Lys Gln Tyr Gln Pro Lys Thr Thr Tyr Ile Ala Tyr Gly Thr 
            180                 185                 190         


Asp Thr Thr Arg Ser Val Leu Lys Ser Ser Asp Glu Lys Val Arg Ser 
        195                 200                 205             


Trp Phe Lys Glu Lys Asn Val Ser Glu Asn Glu Tyr Tyr Leu Val Val 
    210                 215                 220                 


Gly Arg Phe Val Pro Glu Asn Asn Tyr Glu Ser Met Ile Arg Gly Phe 
225                 230                 235                 240 


Leu Ala Ser Asn Ser Lys Lys Asp Phe Val Leu Ile Thr Asn Val Glu 
                245                 250                 255     


Gln Asn Lys Phe Tyr Asn Gln Leu Leu Ala Lys Thr Gly Phe Asp Lys 
            260                 265                 270         


Asp Pro Arg Val Lys Phe Val Gly Thr Val Tyr Glu Gln Glu Leu Leu 
        275                 280                 285             


Lys Tyr Ile Arg Glu Asn Ala Phe Ala Tyr Phe His Gly His Glu Val 
    290                 295                 300                 


Gly Gly Thr Asn Pro Ser Leu Leu Glu Ala Leu Ala Ser Thr Lys Leu 
305                 310                 315                 320 


Asn Leu Leu Leu Asp Val Gly Phe Asn Arg Glu Val Ala Glu Asp Gly 
                325                 330                 335     


Ala Ile Tyr Trp Lys Lys Asp Asn Leu His Glu Ile Ile Glu Thr Ser 
            340                 345                 350         


Glu Gln Lys Thr Gln Lys Glu Ile Asp Glu Lys Asp Ile Leu Ser Ile 
        355                 360                 365             


Lys Gln Val Thr Glu Arg Phe Ser Trp Glu Leu Ile Val Asn Glu Tyr 
    370                 375                 380                 


Glu Lys Leu Phe Leu Cys Glu Lys 
385                 390         


<210>  47
<211>  397
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  47

Met Thr Ile Lys Ile Asn Asn Leu Phe Phe Val Cys Leu Ser Phe Phe 
1               5                   10                  15      


Gly Ile Val Leu Ser Ser Ser Gln Val Ile Val Asn Leu Gly Leu Ser 
            20                  25                  30          


Ser Ile Ile Gln Tyr Ile Ser Tyr Phe Met Leu Met Leu Cys Val Phe 
        35                  40                  45              


Leu Thr Leu Ile Lys Asn Thr Leu Asn Val Phe Ala Asn Arg Ile Ile 
    50                  55                  60                  


Tyr Phe Leu Ile Ile Ser Phe Leu Phe Ile Ile Gly Ile Asn Leu Gln 
65                  70                  75                  80  


Asn Leu Pro Leu Ser Arg Lys Ile Tyr Leu Ser Phe Ser Met Leu Ile 
                85                  90                  95      


Ile Ser Ser Leu Ser Thr Leu Pro Ile Lys Leu Ile Asn Asn Leu Ser 
            100                 105                 110         


Asp Leu Arg Arg Ile Ser Tyr Tyr Leu Leu His Ser Ile Phe Leu Ser 
        115                 120                 125             


Val Phe Leu Gly Leu Val Phe Lys Ile Ser Leu Val Thr Val Ala Val 
    130                 135                 140                 


Glu Gly Ile Gly Phe Ser Tyr Gly Phe Asn Gly Gly Leu Thr His Lys 
145                 150                 155                 160 


Asn Phe Tyr Ala Ile Thr Ile Leu Val Ser Tyr Ile Leu Leu Tyr Val 
                165                 170                 175     


Ser Arg Lys Tyr Asp Ala Lys His Gln Ile Asp Ser Phe Val Leu Trp 
            180                 185                 190         


Leu Asp Leu Phe Leu Leu Leu Ile Ser Asn Thr Arg Thr Val Tyr Ile 
        195                 200                 205             


Ile Leu Val Val Phe Trp Ile Ile Ile Asn Arg Asn Phe Ile Asn Asn 
    210                 215                 220                 


Ile Lys Lys Glu His Arg Leu Val Val Thr Ala Thr Thr Ile Val Ile 
225                 230                 235                 240 


Ser Leu Leu Ala Leu Thr Phe Phe Phe Lys His Ile Ile Asn Asn Ser 
                245                 250                 255     


Glu Ser Tyr Ser His Arg Val Leu Gly Val Val Asn Phe Phe Lys Tyr 
            260                 265                 270         


Tyr Glu Ser Asp Arg Phe His Leu Phe Phe Gly Asp Ala Glu Leu Ala 
        275                 280                 285             


Phe Gly Asn Thr Thr Lys Gly Tyr Gly His Asn Ile Arg Ser Val Leu 
    290                 295                 300                 


Gly Trp Asp Gly Thr Val Glu Met Pro Leu Leu Ser Val Met Ile Lys 
305                 310                 315                 320 


Asn Gly Tyr Val Gly Leu Val Gly Tyr Ile Ile Val Leu Phe Lys Phe 
                325                 330                 335     


Ile Ser Ser Ile Ile Ser Val Lys Asn Ser Thr Lys Lys Asn Ile Gly 
            340                 345                 350         


Leu Ser Ile Phe Ile Pro Leu Leu Leu Ser Ala Thr Val Glu Asn Tyr 
        355                 360                 365             


Ile Val Asn Ile Ser Phe Val Phe Met Pro Val Cys Phe Cys Ile Leu 
    370                 375                 380                 


Cys Ser Ile Lys Asn Ile Lys Leu Val Asn Asn Arg Lys 
385                 390                 395         


<210>  48
<211>  323
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  48

Met Glu Lys Leu Val Ser Ile Ile Leu Pro Val Tyr Asn Val Glu Gln 
1               5                   10                  15      


Tyr Ile Lys Asn Cys Leu Glu Ser Ile Gln Gln Gln Thr Tyr Ser Asn 
            20                  25                  30          


Leu Glu Val Ile Ile Val Asn Asp Gly Ser Thr Asp Lys Ser Val Glu 
        35                  40                  45              


Tyr Cys Glu Gln Ile Cys Lys Ile Asp Ser Arg Phe Ser Ile Thr His 
    50                  55                  60                  


Lys Glu Asn Gly Gly Leu Ser Asp Ala Arg Asn Val Gly Ile Asp Lys 
65                  70                  75                  80  


Ser Lys Gly Asp Tyr Leu Ile Phe Val Asp Ser Asp Asp Phe Val Ser 
                85                  90                  95      


Gln Asp Met Val Ser Tyr Leu Val Ser Cys Met Glu Asn Asn Glu Ala 
            100                 105                 110         


Asp Ile Ala Ile Cys Asp Pro Val His Tyr Tyr Ser Asp Arg Gln Asn 
        115                 120                 125             


Asn Asp Leu Asn Ile Phe Ser Pro Ala Ser Asn Val Lys Val Tyr Glu 
    130                 135                 140                 


Thr Thr Glu Ala Leu Cys Glu Met Phe Tyr Gln Lys Ser Phe Leu Val 
145                 150                 155                 160 


Ser Ala Trp Ala Lys Ile Phe Lys Arg Glu Leu Phe Asp Asp Ile Arg 
                165                 170                 175     


Phe Pro Val Gly Lys Leu Phe Glu Asp Ser Ala Ile Met Tyr Leu Leu 
            180                 185                 190         


Phe Glu Lys Cys Glu Thr Ile Ala Tyr Ser Asp Ala Glu Leu Tyr Ala 
        195                 200                 205             


Tyr Val His Arg Asp Asn Ser Ile Thr Thr Lys Lys Phe Ser Asp Arg 
    210                 215                 220                 


Asp Leu Asp Ile Leu Glu Ile Thr Asn Thr Ile Ile Asn His Tyr Gly 
225                 230                 235                 240 


Asp Asn Leu Arg Val Tyr Thr Ala Ala Val Ser Tyr Lys Val Ser Ala 
                245                 250                 255     


Cys Phe Arg Ile Leu Leu Asn Ser Pro Ser Gly Glu Lys Tyr Lys Lys 
            260                 265                 270         


Val Gln Lys Glu Cys Leu Ser Tyr Ile Leu Gln Asn Trp Arg Asn Ile 
        275                 280                 285             


Leu Phe Asn Asn Asn Val Arg Leu Lys Asn Lys Leu Ala Leu Ile Ser 
    290                 295                 300                 


Ile Thr Ile Phe Asn Pro Phe Val Lys Phe Ile Tyr Ser Lys Val Asn 
305                 310                 315                 320 


Arg Trp Glu 
            


<210>  49
<211>  410
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  49

Met Asn Lys Tyr Glu Glu Arg Tyr Gln Glu Asn Leu Ser Lys Asn Asp 
1               5                   10                  15      


Phe Tyr Lys Leu Ile Asn Lys Ser Tyr Leu Ser Asp Lys Glu Leu Gln 
            20                  25                  30          


Val Gln Gln Val Lys Ala Gly Ile Val Leu Pro Pro Lys Ala Phe Glu 
        35                  40                  45              


Thr Lys Leu Ser Asn Lys Leu Gly Leu Gln Lys Ser Leu His Gly Lys 
    50                  55                  60                  


Gly Gly Val Val Asp Ser Asn Gly Asn Tyr Ile Glu Leu Ser Ala Gln 
65                  70                  75                  80  


Lys Ala Val Gly Met Arg Asn Arg Val Tyr Gly Pro Tyr Lys Ile Asn 
                85                  90                  95      


Tyr Asp Asn Leu Pro Ile Arg Asn Glu Lys Val Ile Tyr Leu Asn Tyr 
            100                 105                 110         


Phe Ile Lys Gln Trp Gly His Phe Leu Leu Asp Val Val Gly Arg Leu 
        115                 120                 125             


Trp Tyr Pro Leu Leu Gln Asp Asn Asp Thr Lys Leu Val Tyr Thr Cys 
    130                 135                 140                 


Tyr Ala Gly Thr Glu Thr Lys Ile Glu Gly Asn Tyr Leu Glu Phe Leu 
145                 150                 155                 160 


Lys Leu Leu Gly Ile Asp Gln Ser Arg Leu Ile Met Ile Asn Cys Pro 
                165                 170                 175     


Thr Gln Phe Ser Glu Val Ile Ile Pro Glu Ser Ser Ile Leu Pro Gly 
            180                 185                 190         


Gly Tyr Tyr Thr Lys Glu Tyr Lys Gln Leu Phe Ser Ser Val Val Glu 
        195                 200                 205             


Asn Ile Lys Leu Asp Lys Tyr Asp Val Asn Ala Lys Met Ile Tyr Cys 
    210                 215                 220                 


Ser Arg Ser Lys Leu Gly Ile Ala Lys Ser Lys Glu Phe Gly Glu Asp 
225                 230                 235                 240 


Gly Ile Glu Gly Ile Phe Lys Gln Asn Gly Tyr Thr Ser Val Tyr Met 
                245                 250                 255     


Glu Thr Met Ser Leu Glu Glu Gln Ile Lys Thr Leu Leu Ser Ala Lys 
            260                 265                 270         


Thr Ile Val Leu Thr Ser Gly Ser Leu Ala His Asn Leu Leu Phe Val 
        275                 280                 285             


Asn Lys Asp Ile Asp Val Phe Ile Leu Asn Lys Thr Tyr Arg Val Asn 
    290                 295                 300                 


Leu His Gln Phe Leu Ile Asn Glu Ile Ser Asp Ala Thr Val Arg Phe 
305                 310                 315                 320 


Val Asp Ile Tyr Arg Ser Pro Leu Pro Ile Leu Tyr Gly Tyr Gly Pro 
                325                 330                 335     


Phe Leu Met Asp Leu Thr Lys Pro Leu Ala Asn Phe Leu Asp Asp Asn 
            340                 345                 350         


Glu Phe Val Tyr Glu Lys Gly Thr Val Leu Ser Lys Lys Asp Tyr Phe 
        355                 360                 365             


Lys Tyr Tyr Leu Lys Trp Leu Trp Ser Tyr Arg Phe Phe Leu Phe Arg 
    370                 375                 380                 


Leu Asn Gly Ile Lys Glu Gly Asn Ser Glu Phe Glu Lys Ser Phe Lys 
385                 390                 395                 400 


Ile Ile Arg Arg Tyr Tyr Lys Thr Gly Arg 
                405                 410 


<210>  50
<211>  461
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  50

Met Ser Lys Tyr Lys Glu Leu Ala Lys Asn Thr Gly Ile Phe Ala Leu 
1               5                   10                  15      


Ala Asn Phe Ser Ser Lys Ile Leu Ile Phe Leu Leu Val Pro Ile Tyr 
            20                  25                  30          


Thr Arg Val Leu Thr Thr Thr Glu Tyr Gly Phe Tyr Asp Leu Val Tyr 
        35                  40                  45              


Thr Thr Ile Gln Leu Phe Val Pro Ile Leu Thr Leu Asn Ile Ser Glu 
    50                  55                  60                  


Ala Val Met Arg Phe Leu Met Lys Asp Gly Val Ser Lys Lys Ser Val 
65                  70                  75                  80  


Phe Ser Ile Ala Val Leu Asp Ile Phe Ile Gly Ser Ile Ala Phe Ala 
                85                  90                  95      


Leu Leu Leu Leu Val Asn Asn Leu Phe Ser Leu Ser Asp Leu Ile Ser 
            100                 105                 110         


Gln Tyr Ser Ile Tyr Ile Phe Val Ile Phe Val Phe Tyr Thr Leu Asn 
        115                 120                 125             


Asn Phe Leu Ile Gln Phe Ser Lys Gly Ile Asp Lys Ile Gly Val Thr 
    130                 135                 140                 


Ala Ile Ser Gly Val Ile Ser Thr Ala Val Met Leu Ala Met Asn Val 
145                 150                 155                 160 


Ile Leu Leu Val Val Phe Asp Trp Gly Leu Leu Gly Phe Phe Ile Ala 
                165                 170                 175     


Asn Val Cys Gly Tyr Val Ile Pro Cys Ile Tyr Ile Val Ser Arg Leu 
            180                 185                 190         


Arg Leu Trp Glu Leu Phe Glu Ile Lys Ile Asp Lys Lys Leu Gln Trp 
        195                 200                 205             


Glu Met Val Tyr Tyr Ala Leu Pro Leu Val Leu Asn Ile Leu Ser Trp 
    210                 215                 220                 


Trp Val Asn Asn Thr Ser Asp Arg Tyr Ile Val Thr Ala Ile Val Gly 
225                 230                 235                 240 


Ile Gln Ala Ser Ala Ile Ile Ser Val Ala Tyr Lys Ile Pro Gln Ile 
                245                 250                 255     


Leu Ser Thr Ile Ser Ala Ile Phe Ile Gln Ser Trp Gln Ile Ser Ala 
            260                 265                 270         


Ile Lys Ile Gln Glu Asp Lys Ser Asp Thr Thr Phe Val Ser Asn Met 
        275                 280                 285             


Leu Leu Tyr Tyr Asn Ala Leu Leu Leu Ile Ile Ala Ser Gly Ile Ile 
    290                 295                 300                 


Leu Phe Val Lys Pro Ile Ser Asn Ile Leu Phe Gly Ile Ser Phe Tyr 
305                 310                 315                 320 


Ser Ala Trp Glu Leu Val Pro Phe Leu Ile Ile Ser Ser Leu Phe Asn 
                325                 330                 335     


Ala Ile Ser Gly Cys Ile Gly Ala Ile Met Gly Ala Lys Met Asp Thr 
            340                 345                 350         


His Asn Ile Ala Lys Ser Ala Leu Val Gly Met Ile Ala Asn Ile Ile 
        355                 360                 365             


Leu Asn Ile Val Leu Thr Phe Leu Met Gly Pro Gln Gly Ile Thr Ile 
    370                 375                 380                 


Ser Thr Leu Ile Ala Ser Phe Leu Ile Phe Tyr Met Arg Lys Asp Ser 
385                 390                 395                 400 


Val Lys Glu Ile Asn Ser Glu Thr Tyr Arg Ala Ile Tyr Leu Ser Trp 
                405                 410                 415     


Ile Leu Leu Val Val Glu Ala Cys Leu Leu Ile Tyr Met Asp Phe Ile 
            420                 425                 430         


Ile Gly Ala Leu Ile Ala Met Val Ile Asn Leu Phe Leu Leu Lys Asp 
        435                 440                 445             


Val Ile Lys Pro Leu Tyr Leu Lys Ile Phe Lys Arg Asn 
    450                 455                 460     


<210>  51
<211>  382
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  51

Met Ile Val Leu Gln Tyr Phe Lys Ile Leu Ala Arg Phe Val Phe Met 
1               5                   10                  15      


Phe Leu Ile Ser Ala Val Leu Leu Pro Phe Lys Ile Lys Pro Asn Lys 
            20                  25                  30          


Ile Val Phe Ile Asn Phe Asn Gly Lys Gly Tyr Gly Asp Asn Pro Lys 
        35                  40                  45              


Ser Ile Cys Glu Tyr Leu Arg Thr Thr Tyr Pro Asp Leu Asp Leu Val 
    50                  55                  60                  


Trp Leu Ala Arg Asp Asn Glu Gly Phe Pro Asp Gly Val Arg Val Val 
65                  70                  75                  80  


Lys Tyr Gly Thr Phe Gln Ala Phe Tyr Glu Gln Ala Ser Ser Lys Val 
                85                  90                  95      


Trp Val Tyr Asn Val Arg Ala Phe Ala Arg Ile Leu Lys Lys Arg Gly 
            100                 105                 110         


Gln Ile Tyr Ile Gln Thr Trp His Gly Ala Ser Ser Phe Lys Leu Ile 
        115                 120                 125             


Glu Lys Gln Ala Asp Leu Pro Ile Asn Tyr Val Leu Glu Ala Lys Tyr 
    130                 135                 140                 


Asp Ala Arg Val Thr Asp Ile Met Ile Ser Asp Ser Arg Lys Gln Thr 
145                 150                 155                 160 


Glu Glu Phe Gln Lys Tyr Phe Trp Tyr Ser Gly Glu Ile Phe Glu Val 
                165                 170                 175     


Gly Met Pro Arg Asn Asp Ala Leu Phe His Tyr Lys Glu Asp Tyr Asp 
            180                 185                 190         


Lys Leu Asn Asn Ile Arg Lys Glu Leu Ser Ile His Ser Asp Asp Tyr 
        195                 200                 205             


Val Ile Leu Tyr Ala Pro Thr Phe Arg Asp Asp Gly Asp Ala Ser Tyr 
    210                 215                 220                 


Leu Asp Ile Asn Phe Glu Arg Leu Leu Gln Cys Val Glu His Gly Ile 
225                 230                 235                 240 


Lys Lys Lys Cys Lys Phe Leu Ile Arg Leu His Pro Asn His Ser His 
                245                 250                 255     


Leu Cys Asn Asn Ile Ser Phe Asn Lys Asn Ile Ile Asn Ala Thr Phe 
            260                 265                 270         


Tyr Ser Asp Met Gln Glu Leu Thr Leu Leu Ala Asp Val Leu Val Thr 
        275                 280                 285             


Asp Tyr Ser Ser Ser Ile Phe Asp Phe Met Leu Leu Asn Lys Pro Tyr 
    290                 295                 300                 


Val Arg Tyr Val Asn Asp Leu Glu Lys Tyr Ala Glu Leu Arg Gly Val 
305                 310                 315                 320 


Ser Asp Thr Tyr Tyr Glu Leu Pro Asp Ser Ile Ile Lys Thr Ala Glu 
                325                 330                 335     


Glu Leu Tyr Asp Leu Leu Pro Lys Lys Ile Glu Asn Phe Asp Tyr Asp 
            340                 345                 350         


Ser Ile Lys Lys Tyr Arg Asn Glu Ile Leu Cys Pro Ile Phe Asn Gly 
        355                 360                 365             


Thr Ala Ser Glu Asn Val Gly Arg Arg Ile Ile Gln Glu Leu 
    370                 375                 380         


<210>  52
<211>  342
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  52

Met Lys Asn Asn Asp Leu Lys Ile Gly Ser Gly Ala Ile His Gln Ile 
1               5                   10                  15      


Ser Ala Thr Leu Ser Gln Asn Ser Ile Ser Gly Lys Ile Leu Tyr Cys 
            20                  25                  30          


Ala Asp Pro Val Val Asp Asp Leu Tyr Gly Ser Ile Val Arg Ser Gln 
        35                  40                  45              


Ile Glu Glu Ile Gly Arg Val Lys Glu Glu Ser Cys Asn Tyr Asn Thr 
    50                  55                  60                  


Ile Ala Tyr Ala Met Asn Ile Ala Glu Arg Ala Ile Ala Thr Asp Ile 
65                  70                  75                  80  


Asp Cys Ile Val Gly Met Gly Gly Gly Arg Val Leu Asp Val Cys Lys 
                85                  90                  95      


Tyr Ala Ser Phe Ile Ser Lys Arg Pro Tyr Leu Ser Ile Pro Thr Thr 
            100                 105                 110         


Ala Ala Asn Asp Gly Ile Ala Ser Pro Val Ala Val Leu Lys Arg Gln 
        115                 120                 125             


Asp Asp Arg Pro Lys Ser Leu Gly Ala Ala Ile Pro Ser Met Thr Leu 
    130                 135                 140                 


Ile Asp Ile Asp Val Ile Ala Ser Gly Pro Ile Gln Asn Ile Lys Ala 
145                 150                 155                 160 


Gly Ile Gly Asp Thr Ile Ser Asn Tyr Thr Ala Leu Lys Asp Trp Glu 
                165                 170                 175     


Leu Ala Val Glu Arg Gly Lys Asp Glu Met His Gly Phe Ala Tyr Leu 
            180                 185                 190         


Met Ser Gln Asn Ser Leu Asp Ala Leu Met Lys Thr Lys Tyr Asn Ser 
        195                 200                 205             


Ile Thr Pro Asp Phe Ile Glu Val Leu Val Asn Ser Leu Val Leu Ser 
    210                 215                 220                 


Gly Ile Ala Met Asp Phe Ala Gly Ser Ser Arg Pro Val Ser Gly Ser 
225                 230                 235                 240 


Glu His Leu Phe Ser His Ala Leu Asp Tyr Tyr Gly Ser Thr Arg Asn 
                245                 250                 255     


Leu His Gly Ile Gln Val Ala Leu Gly Thr Val Ala Val Leu Lys Leu 
            260                 265                 270         


Ile Glu Asn Ser Val Asp Thr Val Val Asp Tyr Leu Gln Arg Phe Glu 
        275                 280                 285             


Val His Ile Asn Pro Lys Leu Leu Gly Ile Asp Glu Glu Leu Phe Ile 
    290                 295                 300                 


Tyr Cys Met Gln His Ala Thr Lys Met Arg Ser Asn Arg Tyr Thr Tyr 
305                 310                 315                 320 


Leu His Glu Val Asp Leu Ser Thr Asp Arg Leu Lys Gln Ile Tyr Lys 
                325                 330                 335     


Glu Leu Ile Ser Glu Leu 
            340         


<210>  53
<211>  234
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  53

Met Lys Ala Leu Ile Leu Ala Ala Gly Leu Gly Thr Arg Leu Ala Pro 
1               5                   10                  15      


Ile Thr Asn Glu Val Pro Lys Ser Leu Val Pro Val Asn Gly Lys Pro 
            20                  25                  30          


Ile Leu Met Lys Gln Ile Glu Asn Leu Tyr Gln Asn Asn Ile Thr Asp 
        35                  40                  45              


Ile Thr Ile Ile Ala Gly Tyr Lys Ser Ser Val Leu Thr Asp Ala Val 
    50                  55                  60                  


Thr Glu Lys Tyr Pro Glu Ile Asn Ile Ile Asp Asn Val Asp Phe Lys 
65                  70                  75                  80  


Thr Thr Asn Asn Met Tyr Ser Ala Tyr Leu Gly Lys Ala Ala Met Gly 
                85                  90                  95      


Asp Ser Asp Phe Leu Met Met Asn Ala Asp Val Phe Tyr Asp Ala Ser 
            100                 105                 110         


Val Ile Lys Ser Leu Leu Leu His Lys Ala Pro Asn Ala Ile Val Thr 
        115                 120                 125             


Asp Leu Gly Ile Tyr Ile Glu Glu Ser Met Lys Val Val Glu Lys Asn 
    130                 135                 140                 


Gly Arg Leu Val Glu Ile Ser Lys Gln Ile Ser Pro Glu Glu Thr Leu 
145                 150                 155                 160 


Gly Ala Ser Ile Asp Val Tyr Lys Phe Ser Tyr Glu Ala Gly Ala Arg 
                165                 170                 175     


Phe Phe Glu Lys Cys Lys Glu Phe Ile Glu Asp Lys Arg Glu Leu Gln 
            180                 185                 190         


Met Trp Ser Glu Val Ala Leu Asn Ala Ile Leu Ser Glu Val Glu Phe 
        195                 200                 205             


Val Ala Cys Pro Leu Glu Gly Arg Trp Leu Glu Ile Asp Asn His Glu 
    210                 215                 220                 


Asp Leu Val Ala Ala Glu Lys Leu Phe Ala 
225                 230                 


<210>  54
<211>  277
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  54

Met Lys Leu Thr Asn Arg Val Asp Tyr Phe Gly Ala Asp Ile Ser Glu 
1               5                   10                  15      


Leu Gln Asn Lys Lys Leu Phe Leu Phe Asp Met Asp Gly Thr Ile Tyr 
            20                  25                  30          


Glu Glu Asp Arg Leu Phe Glu Gly Thr Leu Glu Leu Leu Asp Tyr Ile 
        35                  40                  45              


His Asn Ile Gly Gly Glu Tyr Ile Phe Ile Thr Asn Asn Ser Ser Lys 
    50                  55                  60                  


Ser Val Val Asp Tyr Val Glu Lys Val Asn Arg Leu Gly Ile Lys Ala 
65                  70                  75                  80  


Glu Arg Asp Asn Phe Phe Thr Ser Ala Gln Ala Thr Ile Val Tyr Ile 
                85                  90                  95      


Lys Glu Asn Tyr Pro Lys Ser Lys Val Tyr Cys Gln Gly Thr Lys Ser 
            100                 105                 110         


Leu Ile Lys Glu Leu Ser Asp Ala Gly Ile Asp Val Thr Glu Gln Val 
        115                 120                 125             


Ser Ala Asp Ile Asp Val Val Leu Val Gly Phe Asp Thr Glu Leu Thr 
    130                 135                 140                 


Ser Asp Lys Ile Arg Asn Thr Cys Glu Ile Leu Ser Thr Lys Asp Val 
145                 150                 155                 160 


Pro Phe Ile Ala Thr Asn Pro Asp Ile Arg Cys Pro Val Ser Phe Gly 
                165                 170                 175     


Phe Ile Pro Asp Cys Gly Ser Ile Cys Asp Met Ile Ser Lys Ser Val 
            180                 185                 190         


Asp Arg Lys Pro Val Tyr Ile Gly Lys Pro Glu Pro Thr Met Val Asp 
        195                 200                 205             


Ile Val Arg Lys Lys Leu Asn Tyr Ser Leu Phe Glu Thr Val Val Ile 
    210                 215                 220                 


Gly Asp Arg Leu Tyr Thr Asp Ile Met Thr Gly Ile Asn Ala Gly Val 
225                 230                 235                 240 


Thr Ser Val Cys Val Leu Thr Gly Glu Ala Thr Val Asn Asp Ile Gln 
                245                 250                 255     


Gln Asp Ser Ile Lys Pro Thr Tyr Thr Phe Lys Asn Val Lys Glu Met 
            260                 265                 270         


Trp Lys Gly Ile Val 
        275         


<210>  55
<211>  289
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  55

Met Lys Gly Ile Ile Leu Ala Gly Gly Ser Gly Thr Arg Leu Tyr Pro 
1               5                   10                  15      


Leu Thr Arg Ala Ala Ser Lys Gln Leu Met Pro Val Tyr Asp Lys Pro 
            20                  25                  30          


Met Ile Tyr Tyr Pro Leu Ser Thr Leu Met Leu Ala Gly Ile Arg Asp 
        35                  40                  45              


Ile Leu Ile Ile Ser Thr Pro Gln Asp Leu Pro Arg Phe Lys Glu Leu 
    50                  55                  60                  


Leu Gln Asp Gly Ser Glu Phe Gly Ile Lys Leu Ser Tyr Ala Glu Gln 
65                  70                  75                  80  


Pro Ser Pro Asp Gly Leu Ala Gln Ala Phe Ile Ile Gly Glu Glu Phe 
                85                  90                  95      


Ile Gly Asp Asp Ser Val Ala Leu Ile Leu Gly Asp Asn Ile Tyr His 
            100                 105                 110         


Gly Pro Gly Leu Ser Thr Met Leu Gln Lys Ala Ala Lys Lys Glu Lys 
        115                 120                 125             


Gly Ala Thr Val Phe Gly Tyr His Val Lys Asp Pro Glu Arg Phe Gly 
    130                 135                 140                 


Val Val Glu Phe Asp Glu Asn Met Asn Ala Ile Ser Ile Glu Glu Lys 
145                 150                 155                 160 


Pro Glu Tyr Pro Arg Ser Asn Tyr Ala Val Thr Gly Leu Tyr Phe Tyr 
                165                 170                 175     


Asp Asn Asp Val Val Glu Ile Ala Lys Ser Ile Lys Pro Ser Pro Arg 
            180                 185                 190         


Gly Glu Leu Glu Ile Thr Asp Val Asn Lys Ala Tyr Leu Asp Arg Gly 
        195                 200                 205             


Asp Leu Ser Val Glu Leu Met Gly Arg Gly Phe Ala Trp Leu Asp Thr 
    210                 215                 220                 


Gly Thr His Glu Ser Leu Leu Glu Ala Ser Gln Tyr Ile Glu Thr Val 
225                 230                 235                 240 


Gln Arg Met Gln Asn Val Gln Val Ala Asn Leu Glu Glu Ile Ala Tyr 
                245                 250                 255     


Arg Arg Gly Tyr Ile Ser Arg Glu Asp Val Leu Ala Leu Ala Gln Ser 
            260                 265                 270         


Leu Lys Lys Asn Glu Tyr Gly Gln Tyr Leu Leu Arg Leu Ile Gly Glu 
        275                 280                 285             


Ala 
    


<210>  56
<211>  197
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  56

Met Thr Asp Asn Phe Phe Gly Lys Thr Leu Ala Ala Arg Lys Val Glu 
1               5                   10                  15      


Ala Ile Pro Gly Met Leu Glu Phe Asp Ile Pro Val His Gly Asp Asn 
            20                  25                  30          


Arg Gly Trp Phe Lys Glu Asn Phe Gln Lys Glu Lys Met Leu Pro Leu 
        35                  40                  45              


Gly Phe Pro Glu Ser Phe Phe Ala Glu Gly Lys Leu Gln Asn Asn Val 
    50                  55                  60                  


Ser Phe Ser Arg Lys Asn Val Leu Arg Gly Leu His Ala Glu Pro Trp 
65                  70                  75                  80  


Asp Lys Tyr Ile Ser Val Ala Asp Gly Gly Lys Val Leu Gly Ser Trp 
                85                  90                  95      


Val Asp Leu Arg Glu Gly Glu Thr Phe Gly Asn Thr Tyr Gln Thr Val 
            100                 105                 110         


Ile Asp Ala Ser Lys Gly Ile Phe Val Pro Arg Gly Val Ala Asn Gly 
        115                 120                 125             


Phe Gln Val Leu Ser Asp Thr Val Ser Tyr Ser Tyr Leu Val Asn Asp 
    130                 135                 140                 


Tyr Trp Ala Leu Glu Leu Lys Pro Lys Tyr Ala Phe Val Asn Tyr Ala 
145                 150                 155                 160 


Asp Pro Ser Leu Gly Ile Glu Trp Glu Asn Ile Ala Glu Ala Glu Val 
                165                 170                 175     


Ser Glu Ala Asp Lys Asn His Pro Leu Leu Lys Asp Val Lys Pro Leu 
            180                 185                 190         


Lys Lys Glu Asp Leu 
        195         


<210>  57
<211>  349
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  57

Met Thr Glu Tyr Lys Asn Ile Ile Val Thr Gly Gly Ala Gly Phe Ile 
1               5                   10                  15      


Gly Ser Asn Phe Val His Tyr Val Tyr Glu Asn Phe Pro Asp Val His 
            20                  25                  30          


Val Thr Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Arg Ala Asn Ile 
        35                  40                  45              


Glu Glu Ile Leu Gly Asn Arg Val Glu Leu Val Val Gly Asp Ile Ala 
    50                  55                  60                  


Asp Ala Glu Leu Val Asp Lys Leu Ala Ala Gln Ala Asp Ala Ile Val 
65                  70                  75                  80  


His Tyr Ala Ala Glu Ser His Asn Asp Asn Ser Leu Asn Asp Pro Ser 
                85                  90                  95      


Pro Phe Ile His Thr Asn Phe Ile Gly Thr Tyr Thr Leu Leu Glu Ala 
            100                 105                 110         


Ala Arg Lys Tyr Asp Ile Arg Phe His His Val Ser Thr Asp Glu Val 
        115                 120                 125             


Tyr Gly Asp Leu Pro Leu Arg Glu Asp Leu Pro Gly His Gly Glu Gly 
    130                 135                 140                 


Pro Gly Glu Lys Phe Thr Ala Glu Thr Lys Tyr Asn Pro Ser Ser Pro 
145                 150                 155                 160 


Tyr Ser Ser Thr Lys Ala Ala Ser Asp Leu Ile Val Lys Ala Trp Val 
                165                 170                 175     


Arg Ser Phe Gly Val Lys Ala Thr Ile Ser Asn Cys Ser Asn Asn Tyr 
            180                 185                 190         


Gly Pro Tyr Gln His Ile Glu Lys Phe Ile Pro Arg Gln Ile Thr Asn 
        195                 200                 205             


Ile Leu Ser Gly Ile Lys Pro Lys Leu Tyr Gly Glu Gly Lys Asn Val 
    210                 215                 220                 


Arg Asp Trp Ile His Thr Asn Asp His Ser Ser Gly Val Trp Thr Ile 
225                 230                 235                 240 


Leu Thr Lys Gly Gln Ile Gly Glu Thr Tyr Leu Ile Gly Ala Asp Gly 
                245                 250                 255     


Glu Lys Asn Asn Lys Glu Val Leu Glu Leu Ile Leu Lys Glu Met Gly 
            260                 265                 270         


Gln Ala Val Asp Ala Tyr Asp His Val Thr Asp Arg Ala Gly His Asp 
        275                 280                 285             


Leu Arg Tyr Ala Ile Asp Ala Ser Lys Leu Arg Asp Glu Leu Gly Trp 
    290                 295                 300                 


Lys Pro Glu Phe Thr Asn Phe Glu Ala Gly Leu Lys Ala Thr Ile Lys 
305                 310                 315                 320 


Trp Tyr Thr Asp Asn Gln Glu Trp Trp Lys Ala Glu Lys Glu Ala Val 
                325                 330                 335     


Glu Ala Asn Tyr Ala Lys Thr Gln Glu Ile Ile Thr Val 
            340                 345                 


<210>  58
<211>  283
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  58

Met Ile Leu Ile Thr Gly Ala Asn Gly Gln Leu Gly Thr Glu Leu Arg 
1               5                   10                  15      


Tyr Leu Leu Asp Glu Arg Asn Glu Glu Tyr Val Ala Val Asp Val Ala 
            20                  25                  30          


Glu Met Asp Ile Thr Asp Ala Glu Met Val Glu Lys Val Phe Glu Glu 
        35                  40                  45              


Val Lys Pro Thr Leu Val Tyr His Cys Ala Ala Tyr Thr Ala Val Asp 
    50                  55                  60                  


Ala Ala Glu Asp Glu Gly Arg Glu Leu Asp Phe Ala Ile Asn Val Thr 
65                  70                  75                  80  


Gly Thr Lys Asn Val Ala Lys Ala Ser Glu Lys His Gly Ala Thr Leu 
                85                  90                  95      


Val Tyr Ile Ser Thr Asp Tyr Val Phe Asp Gly Lys Lys Pro Val Gly 
            100                 105                 110         


Gln Glu Trp Glu Val Asp Asp Arg Pro Asp Pro Gln Thr Glu Tyr Gly 
        115                 120                 125             


Arg Thr Lys Arg Met Gly Glu Glu Leu Val Glu Lys His Val Ser Asn 
    130                 135                 140                 


Phe Tyr Ile Ile Arg Thr Ala Trp Val Phe Gly Asn Tyr Gly Lys Asn 
145                 150                 155                 160 


Phe Val Phe Thr Met Gln Asn Leu Ala Lys Thr His Lys Thr Leu Thr 
                165                 170                 175     


Val Val Asn Asp Gln Tyr Gly Arg Pro Thr Trp Thr Arg Thr Leu Ala 
            180                 185                 190         


Glu Phe Met Thr Tyr Leu Ala Glu Asn Arg Lys Glu Phe Gly Tyr Tyr 
        195                 200                 205             


His Leu Ser Asn Asp Ala Thr Glu Asp Thr Thr Trp Tyr Asp Phe Ala 
    210                 215                 220                 


Val Glu Ile Leu Lys Gly Thr Asp Val Glu Val Lys Pro Val Asp Ser 
225                 230                 235                 240 


Ser Gln Phe Pro Ala Lys Ala Lys Arg Pro Leu Asn Ser Thr Met Ser 
                245                 250                 255     


Leu Ala Lys Ala Lys Ala Thr Gly Phe Val Ile Pro Thr Trp Gln Asp 
            260                 265                 270         


Ala Leu Gln Glu Phe Tyr Lys Gln Glu Val Arg 
        275                 280             


<210>  59
<211>  358
<212>  PRT
<213>  E. coli

<400>  59

Met Glu Glu Asn Asn Met Lys Thr Val Ala Val Val Gly Thr Val Gly 
1               5                   10                  15      


Val Pro Ala Cys Tyr Gly Gly Phe Glu Ser Leu Val Gln Asn Leu Ile 
            20                  25                  30          


Asp Tyr Gln Ser Asp Gly Ile Gln Tyr Gln Ile Phe Cys Ser Ser Lys 
        35                  40                  45              


Lys Tyr Asp Lys Lys Phe Lys Asn Tyr Lys Asn Ala Glu Leu Ile Tyr 
    50                  55                  60                  


Leu Pro Ile Asn Ala Asn Gly Val Ser Ser Ile Ile Tyr Asp Ile Met 
65                  70                  75                  80  


Cys Leu Ile Ile Cys Leu Phe Lys Arg Pro Asp Val Val Leu Ile Leu 
                85                  90                  95      


Gly Val Ser Gly Cys Leu Phe Leu Pro Ile Tyr Lys Leu Phe Ser Lys 
            100                 105                 110         


Ser Lys Ile Ile Val Asn Ile Asp Gly Leu Glu Trp Arg Arg Asn Lys 
        115                 120                 125             


Trp Gly Thr Phe Ala Lys Lys Phe Leu Lys Ile Ser Glu Ala Ile Ser 
    130                 135                 140                 


Ile Arg Ile Ala Asp Ile Ile Ile Ser Asp Asn Gln Ala Ile Ala Asp 
145                 150                 155                 160 


Tyr Val Glu Asn Lys Tyr Lys Lys Lys Ser Val Val Ile Ala Tyr Gly 
                165                 170                 175     


Gly Asp His Ala Thr Asn Leu Ser Thr Pro Ile Asp Asn Asp Gln Lys 
            180                 185                 190         


Lys Glu Gly Tyr Tyr Leu Gly Leu Cys Arg Ile Glu Pro Glu Asn Asn 
        195                 200                 205             


Ile Glu Met Ile Leu Asn Ala Phe Ile Asn Thr Asp Lys Lys Ile Lys 
    210                 215                 220                 


Phe Met Gly Asn Trp Asp Asn Ser Glu Tyr Gly Arg Gln Leu Lys Lys 
225                 230                 235                 240 


Tyr Tyr Ser Asn Tyr Pro Asn Ile Thr Leu Leu Glu Pro Asn Tyr Asn 
                245                 250                 255     


Ile Glu Glu Leu Tyr Lys Leu Arg Lys Asn Cys Leu Ala Tyr Ile His 
            260                 265                 270         


Gly His Ser Ala Gly Gly Thr Asn Pro Ser Leu Val Glu Ala Met His 
        275                 280                 285             


Phe Asn Ile Pro Ile Phe Ala Phe Asp Cys Asp Phe Asn Arg Tyr Thr 
    290                 295                 300                 


Thr Asn Asn Leu Ala His Tyr Phe Asn Asp Ser Glu Gln Leu Ser Leu 
305                 310                 315                 320 


Leu Ala Glu Ser Leu Ser Phe Gly Asn Leu Lys Cys Arg Val Leu Asp 
                325                 330                 335     


Leu Lys Asn Tyr Ala Glu Asp Met Tyr Asn Trp Arg His Ile Ala Ala 
            340                 345                 350         


Met Tyr Glu Ser Ile Tyr 
        355             


<210>  60
<211>  360
<212>  PRT
<213>  E. coli

<400>  60

Met Thr Glu Gln Phe Ser Glu Lys Lys Ile Asp Val Val Gly Ile Val 
1               5                   10                  15      


Gly Leu Pro Ala Cys Tyr Gly Gly Phe Glu Ser Leu Val Gln Asn Leu 
            20                  25                  30          


Val Asp Tyr Gln Ser Gln Asn Ile Lys Tyr Asn Val Tyr Cys Ser Arg 
        35                  40                  45              


Lys Lys Tyr Lys Asn Thr Pro Lys Lys Tyr Lys Arg Ala Asp Leu Lys 
    50                  55                  60                  


Tyr Ile Pro Phe Asp Ala Asn Gly Ser Ser Ser Ile Leu Tyr Asp Ile 
65                  70                  75                  80  


Tyr Ser Leu Phe Leu Ser Leu Phe Asn Lys Val Asp Val Val Leu Ile 
                85                  90                  95      


Leu Gly Val Ser Gly Cys Val Phe Leu Pro Ile Tyr Arg Phe Phe Ser 
            100                 105                 110         


Ser Ser Lys Val Ile Val Asn Ile Asp Gly Leu Glu Trp Lys Arg Ala 
        115                 120                 125             


Lys Trp Lys Gly Ile Ala Lys Trp Tyr Leu Lys Ile Ser Glu Lys Ile 
    130                 135                 140                 


Ala Val Lys Tyr Ser Asp Val Val Val Ala Asp Asn Glu Ala Ile Ala 
145                 150                 155                 160 


Lys Tyr Val Leu Lys Lys Tyr Gly Leu Glu Ala Lys Ile Ile Ala Tyr 
                165                 170                 175     


Gly Gly Asp His Ser Leu Val Lys Lys Pro Ile Ser Val Ile Lys Glu 
            180                 185                 190         


Asp Tyr Phe Phe Thr Val Cys Arg Ile Glu Pro Glu Asn Asn Ile Arg 
        195                 200                 205             


Met Ile Leu Glu Ala Phe Lys Asn Thr Thr His Ser Leu Lys Ile Val 
    210                 215                 220                 


Gly Asn Trp Asp Ser Ser Leu Tyr Gly Arg Arg Leu Lys Glu Glu Phe 
225                 230                 235                 240 


Gly Asn Tyr Asn Asn Ile Glu Ile Ile Asp Pro Ile Tyr Asp Ser Asp 
                245                 250                 255     


Ile Leu Phe Asn Phe Arg Ser Leu Cys Arg Gly Tyr Ile His Gly His 
            260                 265                 270         


Ser Ala Gly Gly Thr Asn Pro Ser Leu Val Glu Ala Met His Phe Gln 
        275                 280                 285             


Ile Pro Ile Ile Ala Phe Asp Cys Asp Phe Asn Arg Phe Thr Thr Asp 
    290                 295                 300                 


Asn Tyr Ala Phe Tyr Phe Lys Asn Lys Asn Glu Leu Ser Phe Ile Val 
305                 310                 315                 320 


Asn Asp Ile Leu Asn Gly Asn Gln Asn Glu Gln Ala Glu Ile Cys Ala 
                325                 330                 335     


Lys Lys Met Lys Glu Ile Ala Thr Lys Lys Tyr Thr Trp Asp Thr Ile 
            340                 345                 350         


Ala Lys Met Tyr Glu Glu Leu Tyr 
        355                 360 


<210>  61
<211>  351
<212>  PRT
<213>  Cronobacter sakazakii

<400>  61

Met Lys Arg Ile Ala Val Val Gly Thr Val Gly Ile Pro Ala Cys Tyr 
1               5                   10                  15      


Gly Gly Phe Glu Ser Leu Val Glu Asn Leu Thr Lys Tyr Lys Gly Ala 
            20                  25                  30          


Gly Tyr Gln Tyr Tyr Ile Phe Cys Ser Ser Lys Asn Tyr Pro Glu Lys 
        35                  40                  45              


Ser Asp Ser His Asn Asp Ala Gln Leu Ile Tyr Val Pro Leu Lys Ala 
    50                  55                  60                  


Asn Gly Ile Gln Ser Ile Leu Tyr Asp Ile Val Ser Leu Trp Lys Cys 
65                  70                  75                  80  


Leu Phe Leu Lys Val Asp Thr Ile Leu Ile Leu Gly Val Ser Gly Cys 
                85                  90                  95      


Ile Phe Leu Pro Val Phe Arg Leu Leu Ser Asn Ala Lys Ile Ile Thr 
            100                 105                 110         


Asn Ile Asp Gly Leu Glu Trp Lys Arg Glu Lys Trp Asn Tyr Pro Ile 
        115                 120                 125             


Lys Lys Phe Leu Lys Phe Ser Glu Leu Leu Ala Val Lys Tyr Ser His 
    130                 135                 140                 


Ala Ile Val Thr Asp Asn Arg Ala Ile Thr Asp Tyr Val Lys Lys Glu 
145                 150                 155                 160 


Tyr Asn Val Ser Ser Phe Thr Ile Ala Tyr Gly Gly Asp His Ala Val 
                165                 170                 175     


Arg Pro Ser Asn Asn Asn Asn Asn Ile Lys Ser Ser Tyr Ala Leu Gly 
            180                 185                 190         


Leu Cys Arg Ile Glu Pro Glu Asn Asn Val Glu Leu Ile Leu Lys Ala 
        195                 200                 205             


Phe Thr Leu Ser Glu Asp Lys Leu Lys Phe Val Gly Asn Trp Asn Ala 
    210                 215                 220                 


Ser Ser Tyr Gly Arg Met Leu Lys Lys Asn Tyr Ser Asn Tyr Ser Asn 
225                 230                 235                 240 


Ile Glu Leu Ile Glu Pro Ile Tyr Asp Ile Asp Lys Leu Tyr Ile Leu 
                245                 250                 255     


Arg Ser Gly Cys Asp Lys Tyr Ile His Gly His Ser Ala Gly Gly Thr 
            260                 265                 270         


Asn Pro Ser Leu Val Glu Met Met His Phe Gly Val Pro Ile Phe Ala 
        275                 280                 285             


Phe Asp Cys Glu Phe Asn Arg His Ser Thr Asp Asn Lys Ala Phe Tyr 
    290                 295                 300                 


Phe Lys Asp Ala Gln His Leu Ala Asp Leu Val Lys Met Lys Asp Asn 
305                 310                 315                 320 


Thr Glu Leu Glu Lys Asn Ser Cys Asn Met Lys Val Leu Ala Gln Glu 
                325                 330                 335     


Asn Tyr Thr Trp Gln Lys Ile Thr Ala Ser Tyr Glu Ser Leu Tyr 
            340                 345                 350     


<210>  62
<211>  664
<212>  PRT
<213>  Campylobacter jejuni

<400>  62

Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp Met 
1               5                   10                  15      


Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser Ser 
            20                  25                  30          


Leu Ser Thr Leu Thr Tyr Trp Leu Tyr Lys Ile Thr Pro Phe Ser Phe 
        35                  40                  45              


Glu Ser Ile Ile Leu Tyr Met Ser Thr Phe Leu Ser Ser Leu Val Val 
    50                  55                  60                  


Ile Pro Ile Ile Leu Leu Ala Asn Glu Tyr Lys Arg Pro Leu Met Gly 
65                  70                  75                  80  


Phe Val Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn Arg 
                85                  90                  95      


Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu Pro 
            100                 105                 110         


Met Phe Ile Leu Phe Phe Met Val Arg Met Ile Leu Lys Lys Asp Phe 
        115                 120                 125             


Phe Ser Leu Ile Ala Leu Pro Leu Phe Ile Gly Ile Tyr Leu Trp Trp 
    130                 135                 140                 


Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Ile Gly Leu Phe Leu 
145                 150                 155                 160 


Ile Tyr Thr Leu Ile Phe His Arg Lys Glu Lys Ile Phe Tyr Ile Ala 
                165                 170                 175     


Val Ile Leu Ser Ser Leu Thr Leu Ser Asn Ile Ala Trp Phe Tyr Gln 
            180                 185                 190         


Ser Thr Ile Ile Val Ile Leu Phe Ala Leu Phe Ala Leu Glu Gln Lys 
        195                 200                 205             


Arg Leu Asn Phe Val Ile Ile Gly Ile Leu Ala Ser Val Thr Leu Ile 
    210                 215                 220                 


Phe Leu Ile Leu Ser Gly Gly Val Asp Pro Ile Leu Tyr Gln Leu Lys 
225                 230                 235                 240 


Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Thr Gln Gly Phe 
                245                 250                 255     


Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Asn Val Asp 
            260                 265                 270         


Leu Ser Glu Phe Met Arg Arg Ile Ser Gly Ser Glu Ile Val Phe Leu 
        275                 280                 285             


Phe Ser Leu Phe Gly Phe Val Trp Leu Leu Arg Lys His Lys Ser Met 
    290                 295                 300                 


Ile Met Ala Leu Pro Ile Leu Val Leu Gly Phe Leu Ala Leu Lys Gly 
305                 310                 315                 320 


Gly Leu Arg Phe Thr Ile Tyr Ser Val Pro Val Met Ala Leu Gly Phe 
                325                 330                 335     


Gly Phe Leu Leu Ser Glu Phe Lys Ala Ile Leu Val Lys Lys Tyr Ser 
            340                 345                 350         


Gln Leu Thr Ser Asn Val Cys Ile Val Phe Ala Thr Ile Leu Thr Leu 
        355                 360                 365             


Ala Pro Val Phe Ile His Ile Tyr Asn Tyr Lys Ala Pro Thr Val Phe 
    370                 375                 380                 


Ser Gln Asn Glu Ala Ser Leu Leu Asn Gln Leu Lys Asn Ile Ala Asn 
385                 390                 395                 400 


Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro Val Arg 
                405                 410                 415     


Tyr Tyr Ser Asp Val Lys Thr Leu Val Asp Gly Gly Lys His Leu Gly 
            420                 425                 430         


Lys Asp Asn Phe Phe Pro Ser Phe Ala Leu Ser Lys Asp Glu Gln Ala 
        435                 440                 445             


Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Ser Phe 
    450                 455                 460                 


Tyr Ala Pro Gln Asn Asp Ile Leu Lys Thr Asp Ile Leu Gln Ala Met 
465                 470                 475                 480 


Met Lys Asp Tyr Asn Gln Ser Asn Val Asp Leu Phe Leu Ala Ser Leu 
                485                 490                 495     


Ser Lys Pro Asp Phe Lys Ile Asp Thr Pro Lys Thr Arg Asp Ile Tyr 
            500                 505                 510         


Leu Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val Ala Ser 
        515                 520                 525             


Phe Ser Phe Ile Asn Leu Asp Thr Gly Val Leu Asp Lys Pro Phe Thr 
    530                 535                 540                 


Phe Ser Thr Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile Tyr Leu 
545                 550                 555                 560 


Ser Asn Gly Val Val Leu Ser Asp Asp Phe Arg Ser Phe Lys Ile Gly 
                565                 570                 575     


Asp Asn Val Val Ser Val Asn Ser Ile Val Glu Ile Asn Ser Ile Lys 
            580                 585                 590         


Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Lys Ala Gln Phe Tyr 
        595                 600                 605             


Ile Phe Tyr Leu Lys Asp Ser Ala Ile Pro Tyr Ala Gln Phe Ile Leu 
    610                 615                 620                 


Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe Phe Leu 
625                 630                 635                 640 


Gly Asn Tyr Asp Lys Asn Leu Phe Asp Leu Val Ile Asn Ser Arg Asp 
                645                 650                 655     


Ala Lys Val Phe Lys Leu Lys Ile 
            660                 


<210>  63
<211>  257
<212>  PRT
<213>  E. coli

<400>  63

Met Met Val Phe Gly Lys Leu Tyr Leu Ser Ser Leu Gly Tyr Ile Phe 
1               5                   10                  15      


Gly Ser Trp Glu Met Val Leu Gly Pro Phe Gly Tyr Phe Leu Thr Leu 
            20                  25                  30          


Phe Ala Val Trp Ala Ala Ile Asn Ala Phe Asn Met Val Asp Gly Ile 
        35                  40                  45              


Asp Gly Leu Leu Gly Gly Leu Ser Cys Val Ser Phe Ala Ala Ile Gly 
    50                  55                  60                  


Met Ile Leu Trp Phe Asp Gly Gln Thr Ser Leu Ala Ile Trp Cys Phe 
65                  70                  75                  80  


Ala Met Ile Ala Ala Ile Leu Pro Tyr Ile Met Leu Asn Leu Gly Ile 
                85                  90                  95      


Leu Gly Arg Arg Tyr Lys Val Phe Met Gly Asp Ala Gly Ser Thr Leu 
            100                 105                 110         


Ile Gly Phe Thr Val Ile Trp Ile Leu Leu Glu Thr Thr Gln Gly Lys 
        115                 120                 125             


Thr His Pro Ile Ser Pro Val Thr Ala Leu Trp Ile Ile Ala Ile Pro 
    130                 135                 140                 


Leu Met Asp Met Val Ala Ile Met Tyr Arg Arg Leu Arg Lys Gly Met 
145                 150                 155                 160 


Ser Pro Phe Ser Pro Asp Arg Gln His Ile His His Leu Ile Met Arg 
                165                 170                 175     


Ala Gly Phe Thr Ser Arg Gln Ala Phe Val Leu Ile Thr Leu Ala Ala 
            180                 185                 190         


Ala Leu Leu Ala Ser Ile Gly Val Leu Ala Glu Tyr Ser His Phe Val 
        195                 200                 205             


Pro Glu Trp Val Met Leu Val Leu Phe Leu Leu Ala Phe Phe Leu Tyr 
    210                 215                 220                 


Gly Tyr Cys Ile Lys Arg Ala Trp Lys Val Ala Arg Phe Ile Lys Arg 
225                 230                 235                 240 


Val Lys Arg Arg Leu Arg Arg Asn Arg Gly Gly Ser Pro Asn Leu Thr 
                245                 250                 255     


Lys 
    


<210>  64
<211>  207
<212>  PRT
<213>  E. coli

<400>  64

Met Ser Thr Ile Ile Met Asp Leu Cys Ser Tyr Thr Arg Leu Gly Leu 
1               5                   10                  15      


Thr Gly Tyr Leu Leu Ser Arg Gly Val Lys Lys Arg Glu Ile Asn Asp 
            20                  25                  30          


Ile Glu Thr Val Asp Asp Leu Ala Ile Ala Cys Asp Ser Gln Arg Pro 
        35                  40                  45              


Ser Val Val Phe Ile Asn Glu Asp Cys Phe Ile His Asp Ala Ser Asn 
    50                  55                  60                  


Ser Gln Arg Ile Lys Leu Ile Ile Asn Gln His Pro Asn Thr Leu Phe 
65                  70                  75                  80  


Ile Val Phe Met Ala Ile Ala Asn Val His Phe Asp Glu Tyr Leu Leu 
                85                  90                  95      


Val Arg Lys Asn Leu Leu Ile Ser Ser Lys Ser Ile Lys Pro Glu Ser 
            100                 105                 110         


Leu Asp Asp Ile Leu Gly Asp Ile Leu Lys Lys Glu Thr Thr Ile Thr 
        115                 120                 125             


Ser Phe Leu Asn Met Pro Thr Leu Ser Leu Ser Arg Thr Glu Ser Ser 
    130                 135                 140                 


Met Leu Arg Met Trp Met Ala Gly Gln Gly Thr Ile Gln Ile Ser Asp 
145                 150                 155                 160 


Gln Met Asn Ile Lys Ala Lys Thr Val Ser Ser His Lys Gly Asn Ile 
                165                 170                 175     


Lys Arg Lys Ile Lys Thr His Asn Lys Gln Val Ile Tyr His Val Val 
            180                 185                 190         


Arg Leu Thr Asp Asn Val Thr Asn Gly Ile Phe Val Asn Met Arg 
        195                 200                 205         


<210>  65
<211>  713
<212>  PRT
<213>  Campylobacter jejuni

<400>  65

Met Leu Lys Lys Glu Tyr Leu Lys Asn Pro Tyr Leu Val Leu Phe Ala 
1               5                   10                  15      


Met Ile Ile Leu Ala Tyr Val Phe Ser Val Phe Cys Arg Phe Tyr Trp 
            20                  25                  30          


Val Trp Trp Ala Ser Glu Phe Asn Glu Tyr Phe Phe Asn Asn Gln Leu 
        35                  40                  45              


Met Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp 
    50                  55                  60                  


Met Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser 
65                  70                  75                  80  


Ser Leu Ser Ala Leu Thr Tyr Trp Leu Tyr Lys Ile Thr Pro Phe Ser 
                85                  90                  95      


Phe Glu Ser Ile Ile Leu Tyr Met Ser Thr Phe Leu Ser Ser Leu Val 
            100                 105                 110         


Val Ile Pro Thr Ile Leu Leu Ala Asn Glu Tyr Lys Arg Pro Leu Met 
        115                 120                 125             


Gly Phe Ala Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn 
    130                 135                 140                 


Arg Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu 
145                 150                 155                 160 


Pro Met Phe Ile Leu Phe Phe Met Val Arg Met Ile Leu Lys Lys Asp 
                165                 170                 175     


Phe Phe Ser Leu Ile Ala Leu Pro Leu Phe Ile Gly Ile Tyr Leu Trp 
            180                 185                 190         


Trp Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Ile Gly Leu Phe 
        195                 200                 205             


Leu Ile Tyr Thr Leu Ile Phe His Arg Lys Glu Lys Ile Phe Tyr Ile 
    210                 215                 220                 


Ala Val Ile Leu Ser Ser Leu Thr Leu Ser Asn Ile Ala Trp Phe Tyr 
225                 230                 235                 240 


Gln Ser Ala Ile Ile Val Ile Leu Phe Ala Leu Phe Ala Leu Glu Gln 
                245                 250                 255     


Lys Arg Leu Asn Phe Met Ile Ile Gly Ile Leu Gly Ser Ala Thr Leu 
            260                 265                 270         


Ile Phe Leu Ile Leu Ser Gly Gly Val Asp Pro Ile Leu Tyr Gln Leu 
        275                 280                 285             


Lys Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Thr Gln Gly 
    290                 295                 300                 


Phe Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Asn Val 
305                 310                 315                 320 


Asp Leu Ser Glu Phe Met Arg Arg Ile Ser Gly Ser Glu Ile Val Phe 
                325                 330                 335     


Leu Phe Ser Leu Phe Gly Phe Val Trp Leu Leu Arg Lys His Lys Ser 
            340                 345                 350         


Met Ile Met Ala Leu Pro Ile Leu Val Leu Gly Phe Leu Ala Leu Lys 
        355                 360                 365             


Gly Gly Leu Arg Phe Thr Ile Tyr Ser Val Pro Val Met Ala Leu Gly 
    370                 375                 380                 


Phe Gly Phe Leu Leu Ser Glu Phe Lys Ala Ile Met Val Lys Lys Tyr 
385                 390                 395                 400 


Ser Gln Leu Thr Ser Asn Val Cys Ile Val Phe Ala Thr Ile Leu Thr 
                405                 410                 415     


Leu Ala Pro Val Phe Ile His Ile Tyr Asn Tyr Lys Ala Pro Thr Val 
            420                 425                 430         


Phe Ser Gln Asn Glu Ala Ser Leu Leu Asn Gln Leu Lys Asn Ile Ala 
        435                 440                 445             


Asn Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro Val 
    450                 455                 460                 


Arg Tyr Tyr Ser Asp Val Lys Thr Leu Val Asp Gly Gly Lys His Leu 
465                 470                 475                 480 


Gly Lys Asp Asn Phe Phe Pro Ser Phe Ala Leu Ser Lys Asp Glu Gln 
                485                 490                 495     


Ala Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Ser 
            500                 505                 510         


Phe Tyr Ala Pro Gln Asn Asp Ile Leu Lys Thr Asp Ile Leu Gln Ala 
        515                 520                 525             


Met Met Lys Asp Tyr Asn Gln Ser Asn Val Asp Leu Phe Leu Ala Ser 
    530                 535                 540                 


Leu Ser Lys Pro Asp Phe Lys Ile Asp Thr Pro Lys Thr Arg Asp Ile 
545                 550                 555                 560 


Tyr Leu Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val Ala 
                565                 570                 575     


Ser Phe Ser Phe Ile Asn Leu Asp Thr Gly Val Leu Asp Lys Pro Phe 
            580                 585                 590         


Thr Phe Ser Thr Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile Tyr 
        595                 600                 605             


Leu Ser Asn Gly Val Val Leu Ser Asp Asp Phe Arg Ser Phe Lys Ile 
    610                 615                 620                 


Gly Asp Asn Val Val Ser Val Asn Ser Ile Val Glu Ile Asn Ser Ile 
625                 630                 635                 640 


Lys Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Lys Ala Gln Phe 
                645                 650                 655     


Tyr Ile Phe Tyr Leu Lys Asp Ser Ala Ile Pro Tyr Ala Gln Phe Ile 
            660                 665                 670         


Leu Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe Phe 
        675                 680                 685             


Leu Gly Asn Tyr Asp Lys Asn Leu Phe Asp Leu Val Ile Asn Ser Arg 
    690                 695                 700                 


Asp Ala Lys Val Phe Lys Leu Lys Ile 
705                 710             


<210>  66
<211>  378
<212>  PRT
<213>  Salmonella typhimurium

<400>  66

Met Pro Ser Leu Asn Val Lys Gln Glu Lys Asn Gln Ser Phe Ala Gly 
1               5                   10                  15      


Tyr Ser Leu Pro Pro Ala Asn Ser His Glu Ile Asp Leu Phe Ser Leu 
            20                  25                  30          


Ile Glu Val Leu Trp Gln Ala Lys Arg Arg Ile Leu Ala Thr Val Phe 
        35                  40                  45              


Ala Phe Ala Cys Val Gly Leu Leu Leu Ser Phe Leu Leu Pro Gln Lys 
    50                  55                  60                  


Trp Thr Ser Gln Ala Ile Val Thr Pro Ala Glu Ser Val Gln Trp Gln 
65                  70                  75                  80  


Gly Leu Glu Arg Thr Leu Thr Ala Leu Arg Val Leu Asp Met Glu Val 
                85                  90                  95      


Ser Val Asp Arg Gly Ser Val Phe Asn Leu Phe Ile Lys Lys Phe Ser 
            100                 105                 110         


Ser Pro Ser Leu Leu Glu Glu Tyr Leu Arg Ser Ser Pro Tyr Val Met 
        115                 120                 125             


Asp Gln Leu Lys Gly Ala Gln Ile Asp Glu Gln Asp Leu His Arg Ala 
    130                 135                 140                 


Ile Val Leu Leu Ser Glu Lys Met Lys Ala Val Asp Ser Asn Val Gly 
145                 150                 155                 160 


Lys Lys Asn Glu Thr Ser Leu Phe Thr Ser Trp Thr Leu Ser Phe Thr 
                165                 170                 175     


Ala Pro Thr Arg Glu Glu Ala Gln Lys Val Leu Ala Gly Tyr Ile Gln 
            180                 185                 190         


Tyr Ile Ser Asp Ile Val Val Lys Glu Thr Leu Glu Asn Ile Arg Asn 
        195                 200                 205             


Gln Leu Glu Ile Lys Thr Arg Tyr Glu Gln Glu Lys Leu Ala Met Asp 
    210                 215                 220                 


Arg Val Arg Leu Lys Asn Gln Leu Asp Ala Asn Ile Gln Arg Leu His 
225                 230                 235                 240 


Tyr Ser Leu Glu Ile Ala Asn Ala Ala Gly Ile Lys Arg Pro Val Tyr 
                245                 250                 255     


Ser Asn Gly Gln Ala Val Lys Asp Asp Pro Asp Phe Ser Ile Ser Leu 
            260                 265                 270         


Gly Ala Asp Gly Ile Ser Arg Lys Leu Glu Ile Glu Lys Gly Val Thr 
        275                 280                 285             


Asp Val Ala Glu Ile Asp Gly Asp Leu Arg Asn Arg Gln Tyr His Val 
    290                 295                 300                 


Glu Gln Leu Ala Ala Met Asn Val Ser Asp Val Lys Phe Thr Pro Phe 
305                 310                 315                 320 


Lys Tyr Gln Leu Ser Pro Ser Leu Pro Val Lys Lys Asp Gly Pro Gly 
                325                 330                 335     


Lys Ala Ile Ile Ile Ile Leu Ala Ala Leu Ile Gly Gly Met Met Ala 
            340                 345                 350         


Cys Gly Gly Val Leu Leu Arg His Ala Met Val Ser Arg Lys Met Glu 
        355                 360                 365             


Asn Ala Leu Ala Ile Asp Glu Arg Leu Val 
    370                 375             


