                         SEQUENCE LISTING

<110>  ShanghaiTech University
 
<120>  TOPICAL COMPOSITIONS AND USES

<130>  49BD-258138-WO2

<150>  PCT/CN2017/093810
<151>  2017-07-21

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
1               5                   10                  15      


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly 
            20                  25              


<210>  2
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
1               5                   10                  15      


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
            20                  25                  30          


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
        35                  40                  45              


Ala His Gln Arg Thr His Thr Gly 
    50                  55      


<210>  3
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
1               5                   10                  15      


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
            20                  25                  30          


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
        35                  40                  45              


Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
    50                  55                  60                  


Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg 
65                  70                  75                  80  


Thr His Thr Gly 
                


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
1               5                   10                  15      


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
            20                  25                  30          


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
        35                  40                  45              


Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
    50                  55                  60                  


Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg 
65                  70                  75                  80  


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
                85                  90                  95      


Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly 
            100                 105                 110         


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Arg Ile Pro Leu Ser Cys Thr Ile Cys Arg Lys Arg Lys Val Lys Cys 
1               5                   10                  15      


Asp Lys Leu Arg Pro His Cys Gln Gln Cys Thr Lys Thr Gly Val Ala 
            20                  25                  30          


His Leu Cys His Tyr Met 
        35              


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Thr Cys Tyr Asn Cys Gly Gln Thr Gly His Leu Ser Arg Glu Cys Pro 
1               5                   10                  15      


Ser 
    


<210>  7
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Arg Arg Cys Asn Cys Met Ala Thr Arg His Pro Leu Phe Glu Val Ala 
1               5                   10                  15      


Pro Asn Cys Leu Asn Cys Gly Lys Ile Ile Cys Glu Lys Glu Gly Leu 
            20                  25                  30          


Gln Pro Cys Ser Tyr Cys Gly Gln Glu Leu Leu Ser Pro Lys Asp Lys 
        35                  40                  45              


Gln Glu Ile Ile 
    50          


<210>  8
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe 
            420                 425 


<210>  9
<211>  871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser 
1               5                   10                  15      


Leu Asp Lys Gly Tyr Asn Lys Ala Leu Asn Asp Leu Cys Ile Lys Val 
            20                  25                  30          


Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn 
        35                  40                  45              


Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala 
    50                  55                  60                  


Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 
65                  70                  75                  80  


Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser 
                85                  90                  95      


Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe 
            100                 105                 110         


Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr 
        115                 120                 125             


Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr 
    130                 135                 140                 


Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe 
145                 150                 155                 160 


Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala 
                165                 170                 175     


Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu 
            180                 185                 190         


Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile 
        195                 200                 205             


Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys 
    210                 215                 220                 


Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu 
225                 230                 235                 240 


Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu 
                245                 250                 255     


Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn 
            260                 265                 270         


Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile 
        275                 280                 285             


Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg 
    290                 295                 300                 


Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala 
305                 310                 315                 320 


Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn 
                325                 330                 335     


Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile 
            340                 345                 350         


Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val 
        355                 360                 365             


Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu 
    370                 375                 380                 


Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp 
385                 390                 395                 400 


Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val 
                405                 410                 415     


Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val 
            420                 425                 430         


Asp Asn Gln Arg Leu Leu Ser Thr Phe Thr Glu Tyr Ile Lys Asn Ile 
        435                 440                 445             


Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr Glu Ser Asn His Leu Ile 
    450                 455                 460                 


Asp Leu Ser Arg Tyr Ala Ser Lys Ile Asn Ile Gly Ser Lys Val Asn 
465                 470                 475                 480 


Phe Asp Pro Ile Asp Lys Asn Gln Ile Gln Leu Phe Asn Leu Glu Ser 
                485                 490                 495     


Ser Lys Ile Glu Val Ile Leu Lys Asn Ala Ile Val Tyr Asn Ser Met 
            500                 505                 510         


Tyr Glu Asn Phe Ser Thr Ser Phe Trp Ile Arg Ile Pro Lys Tyr Phe 
        515                 520                 525             


Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile Asn Cys Met Glu 
    530                 535                 540                 


Asn Asn Ser Gly Trp Lys Val Ser Leu Asn Tyr Gly Glu Ile Ile Trp 
545                 550                 555                 560 


Thr Leu Gln Asp Thr Gln Glu Ile Lys Gln Arg Val Val Phe Lys Tyr 
                565                 570                 575     


Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg Trp Ile Phe Val 
            580                 585                 590         


Thr Ile Thr Asn Asn Arg Leu Asn Asn Ser Lys Ile Tyr Ile Asn Gly 
        595                 600                 605             


Arg Leu Ile Asp Gln Lys Pro Ile Ser Asn Leu Gly Asn Ile His Ala 
    610                 615                 620                 


Ser Asn Asn Ile Met Phe Lys Leu Asp Gly Cys Arg Asp Thr His Arg 
625                 630                 635                 640 


Tyr Ile Trp Ile Lys Tyr Phe Asn Leu Phe Asp Lys Glu Leu Asn Glu 
                645                 650                 655     


Lys Glu Ile Lys Asp Leu Tyr Asp Asn Gln Ser Asn Ser Gly Ile Leu 
            660                 665                 670         


Lys Asp Phe Trp Gly Asp Tyr Leu Gln Tyr Asp Lys Pro Tyr Tyr Met 
        675                 680                 685             


Leu Asn Leu Tyr Asp Pro Asn Lys Tyr Val Asp Val Asn Asn Val Gly 
    690                 695                 700                 


Ile Arg Gly Tyr Met Tyr Leu Lys Gly Pro Arg Gly Ser Val Met Thr 
705                 710                 715                 720 


Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg Gly Thr Lys Phe Ile 
                725                 730                 735     


Ile Lys Lys Tyr Ala Ser Gly Asn Lys Asp Asn Ile Val Arg Asn Asn 
            740                 745                 750         


Asp Arg Val Tyr Ile Asn Val Val Val Lys Asn Lys Glu Tyr Arg Leu 
        755                 760                 765             


Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys Ile Leu Ser Ala Leu 
    770                 775                 780                 


Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val Val Val Met Lys Ser 
785                 790                 795                 800 


Lys Asn Asp Gln Gly Ile Thr Asn Lys Cys Lys Met Asn Leu Gln Asp 
                805                 810                 815     


Asn Asn Gly Asn Asp Ile Gly Phe Ile Gly Phe His Gln Phe Asn Asn 
            820                 825                 830         


Ile Ala Lys Leu Val Ala Ser Asn Trp Tyr Asn Arg Gln Ile Glu Arg 
        835                 840                 845             


Ser Ser Arg Thr Leu Gly Cys Ser Trp Glu Phe Ile Pro Val Asp Asp 
    850                 855                 860                 


Gly Trp Gly Glu Arg Pro Leu 
865                 870     


<210>  10
<211>  1312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
            20                  25                  30          


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro 
        35                  40                  45              


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
    50                  55                  60                  


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
65                  70                  75                  80  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
                85                  90                  95      


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
            100                 105                 110         


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
        115                 120                 125             


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
    130                 135                 140                 


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
145                 150                 155                 160 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
                165                 170                 175     


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
            180                 185                 190         


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
        195                 200                 205             


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
    210                 215                 220                 


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
225                 230                 235                 240 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
                245                 250                 255     


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
            260                 265                 270         


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
        275                 280                 285             


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
    290                 295                 300                 


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
305                 310                 315                 320 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
                325                 330                 335     


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
            340                 345                 350         


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
        355                 360                 365             


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
    370                 375                 380                 


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
385                 390                 395                 400 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
                405                 410                 415     


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
            420                 425                 430         


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
        435                 440                 445             


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
    450                 455                 460                 


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
465                 470                 475                 480 


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
                485                 490                 495     


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
            500                 505                 510         


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
        515                 520                 525             


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
    530                 535                 540                 


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
545                 550                 555                 560 


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
                565                 570                 575     


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
            580                 585                 590         


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
        595                 600                 605             


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
    610                 615                 620                 


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
625                 630                 635                 640 


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
                645                 650                 655     


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
            660                 665                 670         


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
        675                 680                 685             


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
    690                 695                 700                 


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
705                 710                 715                 720 


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
                725                 730                 735     


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
            740                 745                 750         


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
        755                 760                 765             


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
    770                 775                 780                 


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
785                 790                 795                 800 


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
                805                 810                 815     


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
            820                 825                 830         


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
        835                 840                 845             


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
    850                 855                 860                 


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
865                 870                 875                 880 


Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
                885                 890                 895     


Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
            900                 905                 910         


Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
        915                 920                 925             


Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
    930                 935                 940                 


Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
945                 950                 955                 960 


Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
                965                 970                 975     


Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
            980                 985                 990         


Ser Leu Asn Tyr Gly Glu Ile Ile  Trp Thr Leu Gln Asp  Thr Gln Glu 
        995                 1000                 1005             


Ile Lys  Gln Arg Val Val Phe  Lys Tyr Ser Gln Met  Ile Asn Ile 
    1010                 1015                 1020             


Ser Asp  Tyr Ile Asn Arg Trp  Ile Phe Val Thr Ile  Thr Asn Asn 
    1025                 1030                 1035             


Arg Leu  Asn Asn Ser Lys Ile  Tyr Ile Asn Gly Arg  Leu Ile Asp 
    1040                 1045                 1050             


Gln Lys  Pro Ile Ser Asn Leu  Gly Asn Ile His Ala  Ser Asn Asn 
    1055                 1060                 1065             


Ile Met  Phe Lys Leu Asp Gly  Cys Arg Asp Thr His  Arg Tyr Ile 
    1070                 1075                 1080             


Trp Ile  Lys Tyr Phe Asn Leu  Phe Asp Lys Glu Leu  Asn Glu Lys 
    1085                 1090                 1095             


Glu Ile  Lys Asp Leu Tyr Asp  Asn Gln Ser Asn Ser  Gly Ile Leu 
    1100                 1105                 1110             


Lys Asp  Phe Trp Gly Asp Tyr  Leu Gln Tyr Asp Lys  Pro Tyr Tyr 
    1115                 1120                 1125             


Met Leu  Asn Leu Tyr Asp Pro  Asn Lys Tyr Val Asp  Val Asn Asn 
    1130                 1135                 1140             


Val Gly  Ile Arg Gly Tyr Met  Tyr Leu Lys Gly Pro  Arg Gly Ser 
    1145                 1150                 1155             


Val Met  Thr Thr Asn Ile Tyr  Leu Asn Ser Ser Leu  Tyr Arg Gly 
    1160                 1165                 1170             


Thr Lys  Phe Ile Ile Lys Lys  Tyr Ala Ser Gly Asn  Lys Asp Asn 
    1175                 1180                 1185             


Ile Val  Arg Asn Asn Asp Arg  Val Tyr Ile Asn Val  Val Val Lys 
    1190                 1195                 1200             


Asn Lys  Glu Tyr Arg Leu Ala  Thr Asn Ala Ser Gln  Ala Gly Val 
    1205                 1210                 1215             


Glu Lys  Ile Leu Ser Ala Leu  Glu Ile Pro Asp Val  Gly Asn Leu 
    1220                 1225                 1230             


Ser Gln  Val Val Val Met Lys  Ser Lys Asn Asp Gln  Gly Ile Thr 
    1235                 1240                 1245             


Asn Lys  Cys Lys Met Asn Leu  Gln Asp Asn Asn Gly  Asn Asp Ile 
    1250                 1255                 1260             


Gly Phe  Ile Gly Phe His Gln  Phe Asn Asn Ile Ala  Lys Leu Val 
    1265                 1270                 1275             


Ala Ser  Asn Trp Tyr Asn Arg  Gln Ile Glu Arg Ser  Ser Arg Thr 
    1280                 1285                 1290             


Leu Gly  Cys Ser Trp Glu Phe  Ile Pro Val Asp Asp  Gly Trp Gly 
    1295                 1300                 1305             


Glu Arg  Pro Leu 
    1310         


<210>  11
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
            20                  25                  30          


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
        35                  40                  45              


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
    50                  55                  60                  


Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Pro Phe 
            100                 105                 110         


Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile 
        115                 120                 125             


Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro Val Lys Ala 
    130                 135                 140                 


Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe 
145                 150                 155                 160 


Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln 
                165                 170                 175     


Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu 
            180                 185                 190         


Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr 
        195                 200                 205             


Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile 
    210                 215                 220                 


Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp 
225                 230                 235                 240 


Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu 
                245                 250                 255     


Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe 
            260                 265                 270         


Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly 
        275                 280                 285             


Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly 
    290                 295                 300                 


Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly 
305                 310                 315                 320 


Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His 
                325                 330                 335     


Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe 
            340                 345                 350         


Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser 
        355                 360                 365             


Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp 
    370                 375                 380                 


Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys 
385                 390                 395                 400 


Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr 
                405                 410                 415     


Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu 
            420                 425                 430         


Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp 
        435                 440                 445             


Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val 
    450                 455                 460                 


Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys 
465                 470                 475                 480 


Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr 
                485                 490                 495     


Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly 
            500                 505                 510         


Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe 
        515                 520                 525             


Thr Gly Leu Phe Glu Phe 
    530                 


<210>  12
<211>  1405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
            20                  25                  30          


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
        35                  40                  45              


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
    50                  55                  60                  


Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Pro Phe 
            100                 105                 110         


Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile 
        115                 120                 125             


Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro Val Lys Ala 
    130                 135                 140                 


Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe 
145                 150                 155                 160 


Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln 
                165                 170                 175     


Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu 
            180                 185                 190         


Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr 
        195                 200                 205             


Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile 
    210                 215                 220                 


Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp 
225                 230                 235                 240 


Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu 
                245                 250                 255     


Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe 
            260                 265                 270         


Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly 
        275                 280                 285             


Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly 
    290                 295                 300                 


Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly 
305                 310                 315                 320 


Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His 
                325                 330                 335     


Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe 
            340                 345                 350         


Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser 
        355                 360                 365             


Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp 
    370                 375                 380                 


Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys 
385                 390                 395                 400 


Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr 
                405                 410                 415     


Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu 
            420                 425                 430         


Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp 
        435                 440                 445             


Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val 
    450                 455                 460                 


Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys 
465                 470                 475                 480 


Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr 
                485                 490                 495     


Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly 
            500                 505                 510         


Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe 
        515                 520                 525             


Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile 
    530                 535                 540                 


Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys Ala Leu Asn 
545                 550                 555                 560 


Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser 
                565                 570                 575     


Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser 
            580                 585                 590         


Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile 
        595                 600                 605             


Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile 
    610                 615                 620                 


Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met 
625                 630                 635                 640 


Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys 
                645                 650                 655     


Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys 
            660                 665                 670         


Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro 
        675                 680                 685             


Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn 
    690                 695                 700                 


Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val 
705                 710                 715                 720 


Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile 
                725                 730                 735     


Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 
            740                 745                 750         


Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser 
        755                 760                 765             


Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val 
    770                 775                 780                 


Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr 
785                 790                 795                 800 


Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp 
                805                 810                 815     


Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr 
            820                 825                 830         


Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 
        835                 840                 845             


Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 
    850                 855                 860                 


Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser 
865                 870                 875                 880 


Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe 
                885                 890                 895     


Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr 
            900                 905                 910         


Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu 
        915                 920                 925             


Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp 
    930                 935                 940                 


Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe 
945                 950                 955                 960 


Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe Thr 
                965                 970                 975     


Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr 
            980                 985                 990         


Glu Ser Asn His Leu Ile Asp Leu  Ser Arg Tyr Ala Ser  Lys Ile Asn 
        995                 1000                 1005             


Ile Gly  Ser Lys Val Asn Phe  Asp Pro Ile Asp Lys  Asn Gln Ile 
    1010                 1015                 1020             


Gln Leu  Phe Asn Leu Glu Ser  Ser Lys Ile Glu Val  Ile Leu Lys 
    1025                 1030                 1035             


Asn Ala  Ile Val Tyr Asn Ser  Met Tyr Glu Asn Phe  Ser Thr Ser 
    1040                 1045                 1050             


Phe Trp  Ile Arg Ile Pro Lys  Tyr Phe Asn Ser Ile  Ser Leu Asn 
    1055                 1060                 1065             


Asn Glu  Tyr Thr Ile Ile Asn  Cys Met Glu Asn Asn  Ser Gly Trp 
    1070                 1075                 1080             


Lys Val  Ser Leu Asn Tyr Gly  Glu Ile Ile Trp Thr  Leu Gln Asp 
    1085                 1090                 1095             


Thr Gln  Glu Ile Lys Gln Arg  Val Val Phe Lys Tyr  Ser Gln Met 
    1100                 1105                 1110             


Ile Asn  Ile Ser Asp Tyr Ile  Asn Arg Trp Ile Phe  Val Thr Ile 
    1115                 1120                 1125             


Thr Asn  Asn Arg Leu Asn Asn  Ser Lys Ile Tyr Ile  Asn Gly Arg 
    1130                 1135                 1140             


Leu Ile  Asp Gln Lys Pro Ile  Ser Asn Leu Gly Asn  Ile His Ala 
    1145                 1150                 1155             


Ser Asn  Asn Ile Met Phe Lys  Leu Asp Gly Cys Arg  Asp Thr His 
    1160                 1165                 1170             


Arg Tyr  Ile Trp Ile Lys Tyr  Phe Asn Leu Phe Asp  Lys Glu Leu 
    1175                 1180                 1185             


Asn Glu  Lys Glu Ile Lys Asp  Leu Tyr Asp Asn Gln  Ser Asn Ser 
    1190                 1195                 1200             


Gly Ile  Leu Lys Asp Phe Trp  Gly Asp Tyr Leu Gln  Tyr Asp Lys 
    1205                 1210                 1215             


Pro Tyr  Tyr Met Leu Asn Leu  Tyr Asp Pro Asn Lys  Tyr Val Asp 
    1220                 1225                 1230             


Val Asn  Asn Val Gly Ile Arg  Gly Tyr Met Tyr Leu  Lys Gly Pro 
    1235                 1240                 1245             


Arg Gly  Ser Val Met Thr Thr  Asn Ile Tyr Leu Asn  Ser Ser Leu 
    1250                 1255                 1260             


Tyr Arg  Gly Thr Lys Phe Ile  Ile Lys Lys Tyr Ala  Ser Gly Asn 
    1265                 1270                 1275             


Lys Asp  Asn Ile Val Arg Asn  Asn Asp Arg Val Tyr  Ile Asn Val 
    1280                 1285                 1290             


Val Val  Lys Asn Lys Glu Tyr  Arg Leu Ala Thr Asn  Ala Ser Gln 
    1295                 1300                 1305             


Ala Gly  Val Glu Lys Ile Leu  Ser Ala Leu Glu Ile  Pro Asp Val 
    1310                 1315                 1320             


Gly Asn  Leu Ser Gln Val Val  Val Met Lys Ser Lys  Asn Asp Gln 
    1325                 1330                 1335             


Gly Ile  Thr Asn Lys Cys Lys  Met Asn Leu Gln Asp  Asn Asn Gly 
    1340                 1345                 1350             


Asn Asp  Ile Gly Phe Ile Gly  Phe His Gln Phe Asn  Asn Ile Ala 
    1355                 1360                 1365             


Lys Leu  Val Ala Ser Asn Trp  Tyr Asn Arg Gln Ile  Glu Arg Ser 
    1370                 1375                 1380             


Ser Arg  Thr Leu Gly Cys Ser  Trp Glu Phe Ile Pro  Val Asp Asp 
    1385                 1390                 1395             


Gly Trp  Gly Glu Arg Pro Leu  
    1400                 1405 


<210>  13
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser 
        435                 440                 445             


Ala Ser Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala 
465                 470                 475                 480 


Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
                485                 490                 495     


Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His 
            500                 505                 510         


Gln Arg Thr His Thr Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser His 
        515                 520                 525             


His His His His His 
    530             


<210>  14
<211>  1404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
    450                 455                 460                 


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
465                 470                 475                 480 


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
                485                 490                 495     


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
            500                 505                 510         


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
        515                 520                 525             


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
    530                 535                 540                 


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
545                 550                 555                 560 


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
                565                 570                 575     


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
            580                 585                 590         


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
        595                 600                 605             


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
    610                 615                 620                 


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
625                 630                 635                 640 


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
                645                 650                 655     


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
            660                 665                 670         


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
        675                 680                 685             


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
    690                 695                 700                 


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
705                 710                 715                 720 


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
                725                 730                 735     


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
            740                 745                 750         


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
        755                 760                 765             


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
    770                 775                 780                 


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
785                 790                 795                 800 


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
                805                 810                 815     


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
            820                 825                 830         


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
        835                 840                 845             


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
    850                 855                 860                 


Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
865                 870                 875                 880 


Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
                885                 890                 895     


Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
            900                 905                 910         


Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
        915                 920                 925             


Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
    930                 935                 940                 


Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
945                 950                 955                 960 


Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
                965                 970                 975     


Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu 
            980                 985                 990         


Ile Lys Gln Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
        995                 1000                 1005             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1010                 1015                 1020             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1025                 1030                 1035             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1040                 1045                 1050             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1055                 1060                 1065             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1070                 1075                 1080             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1085                 1090                 1095             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1100                 1105                 1110             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1115                 1120                 1125             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1130                 1135                 1140             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1145                 1150                 1155             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1160                 1165                 1170             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1175                 1180                 1185             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1190                 1195                 1200             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1205                 1210                 1215             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1220                 1225                 1230             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1235                 1240                 1245             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1250                 1255                 1260             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1265                 1270                 1275             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1280                 1285                 1290             


Arg Pro  Leu Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Glu Lys Pro 
    1295                 1300                 1305             


Tyr Lys  Cys Pro Glu Cys Gly  Lys Ser Phe Ser Ala  Ser Ala Ala 
    1310                 1315                 1320             


Leu Val  Ala His Gln Arg Thr  His Thr Gly Glu Lys  Pro Tyr Lys 
    1325                 1330                 1335             


Cys Pro  Glu Cys Gly Lys Ser  Phe Ser Ala Ser Ala  Ala Leu Val 
    1340                 1345                 1350             


Ala His  Gln Arg Thr His Thr  Gly Glu Lys Pro Tyr  Lys Cys Pro 
    1355                 1360                 1365             


Glu Cys  Gly Lys Ser Phe Ser  Ala Ser Ala Ala Leu  Val Ala His 
    1370                 1375                 1380             


Gln Arg  Thr His Thr Gly Gly  Gly Ser Gly Gly Ser  Gly Gly Ser 
    1385                 1390                 1395             


His His  His His His His 
    1400                 


<210>  15
<211>  1498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser 
            20                  25                  30          


Ala Ala Leu Val Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
        35                  40                  45              


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val 
    50                  55                  60                  


Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Ala Ser Ala Ala Leu Val Ala His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Pro Phe 
            100                 105                 110         


Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile 
        115                 120                 125             


Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro Val Lys Ala 
    130                 135                 140                 


Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe 
145                 150                 155                 160 


Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln 
                165                 170                 175     


Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu 
            180                 185                 190         


Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr 
        195                 200                 205             


Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile 
    210                 215                 220                 


Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp 
225                 230                 235                 240 


Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu 
                245                 250                 255     


Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe 
            260                 265                 270         


Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly 
        275                 280                 285             


Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly 
    290                 295                 300                 


Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly 
305                 310                 315                 320 


Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His 
                325                 330                 335     


Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe 
            340                 345                 350         


Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser 
        355                 360                 365             


Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp 
    370                 375                 380                 


Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys 
385                 390                 395                 400 


Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr 
                405                 410                 415     


Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu 
            420                 425                 430         


Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp 
        435                 440                 445             


Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val 
    450                 455                 460                 


Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys 
465                 470                 475                 480 


Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr 
                485                 490                 495     


Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly 
            500                 505                 510         


Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe 
        515                 520                 525             


Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile 
    530                 535                 540                 


Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys Ala Leu Asn 
545                 550                 555                 560 


Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser 
                565                 570                 575     


Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser 
            580                 585                 590         


Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile 
        595                 600                 605             


Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile 
    610                 615                 620                 


Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met 
625                 630                 635                 640 


Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys 
                645                 650                 655     


Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys 
            660                 665                 670         


Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro 
        675                 680                 685             


Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn 
    690                 695                 700                 


Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val 
705                 710                 715                 720 


Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile 
                725                 730                 735     


Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 
            740                 745                 750         


Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser 
        755                 760                 765             


Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val 
    770                 775                 780                 


Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr 
785                 790                 795                 800 


Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp 
                805                 810                 815     


Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr 
            820                 825                 830         


Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln 
        835                 840                 845             


Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr 
    850                 855                 860                 


Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser 
865                 870                 875                 880 


Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe 
                885                 890                 895     


Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr 
            900                 905                 910         


Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu 
        915                 920                 925             


Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp 
    930                 935                 940                 


Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe 
945                 950                 955                 960 


Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe Thr 
                965                 970                 975     


Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr 
            980                 985                 990         


Glu Ser Asn His Leu Ile Asp Leu  Ser Arg Tyr Ala Ser  Lys Ile Asn 
        995                 1000                 1005             


Ile Gly  Ser Lys Val Asn Phe  Asp Pro Ile Asp Lys  Asn Gln Ile 
    1010                 1015                 1020             


Gln Leu  Phe Asn Leu Glu Ser  Ser Lys Ile Glu Val  Ile Leu Lys 
    1025                 1030                 1035             


Asn Ala  Ile Val Tyr Asn Ser  Met Tyr Glu Asn Phe  Ser Thr Ser 
    1040                 1045                 1050             


Phe Trp  Ile Arg Ile Pro Lys  Tyr Phe Asn Ser Ile  Ser Leu Asn 
    1055                 1060                 1065             


Asn Glu  Tyr Thr Ile Ile Asn  Cys Met Glu Asn Asn  Ser Gly Trp 
    1070                 1075                 1080             


Lys Val  Ser Leu Asn Tyr Gly  Glu Ile Ile Trp Thr  Leu Gln Asp 
    1085                 1090                 1095             


Thr Gln  Glu Ile Lys Gln Arg  Val Val Phe Lys Tyr  Ser Gln Met 
    1100                 1105                 1110             


Ile Asn  Ile Ser Asp Tyr Ile  Asn Arg Trp Ile Phe  Val Thr Ile 
    1115                 1120                 1125             


Thr Asn  Asn Arg Leu Asn Asn  Ser Lys Ile Tyr Ile  Asn Gly Arg 
    1130                 1135                 1140             


Leu Ile  Asp Gln Lys Pro Ile  Ser Asn Leu Gly Asn  Ile His Ala 
    1145                 1150                 1155             


Ser Asn  Asn Ile Met Phe Lys  Leu Asp Gly Cys Arg  Asp Thr His 
    1160                 1165                 1170             


Arg Tyr  Ile Trp Ile Lys Tyr  Phe Asn Leu Phe Asp  Lys Glu Leu 
    1175                 1180                 1185             


Asn Glu  Lys Glu Ile Lys Asp  Leu Tyr Asp Asn Gln  Ser Asn Ser 
    1190                 1195                 1200             


Gly Ile  Leu Lys Asp Phe Trp  Gly Asp Tyr Leu Gln  Tyr Asp Lys 
    1205                 1210                 1215             


Pro Tyr  Tyr Met Leu Asn Leu  Tyr Asp Pro Asn Lys  Tyr Val Asp 
    1220                 1225                 1230             


Val Asn  Asn Val Gly Ile Arg  Gly Tyr Met Tyr Leu  Lys Gly Pro 
    1235                 1240                 1245             


Arg Gly  Ser Val Met Thr Thr  Asn Ile Tyr Leu Asn  Ser Ser Leu 
    1250                 1255                 1260             


Tyr Arg  Gly Thr Lys Phe Ile  Ile Lys Lys Tyr Ala  Ser Gly Asn 
    1265                 1270                 1275             


Lys Asp  Asn Ile Val Arg Asn  Asn Asp Arg Val Tyr  Ile Asn Val 
    1280                 1285                 1290             


Val Val  Lys Asn Lys Glu Tyr  Arg Leu Ala Thr Asn  Ala Ser Gln 
    1295                 1300                 1305             


Ala Gly  Val Glu Lys Ile Leu  Ser Ala Leu Glu Ile  Pro Asp Val 
    1310                 1315                 1320             


Gly Asn  Leu Ser Gln Val Val  Val Met Lys Ser Lys  Asn Asp Gln 
    1325                 1330                 1335             


Gly Ile  Thr Asn Lys Cys Lys  Met Asn Leu Gln Asp  Asn Asn Gly 
    1340                 1345                 1350             


Asn Asp  Ile Gly Phe Ile Gly  Phe His Gln Phe Asn  Asn Ile Ala 
    1355                 1360                 1365             


Lys Leu  Val Ala Ser Asn Trp  Tyr Asn Arg Gln Ile  Glu Arg Ser 
    1370                 1375                 1380             


Ser Arg  Thr Leu Gly Cys Ser  Trp Glu Phe Ile Pro  Val Asp Asp 
    1385                 1390                 1395             


Gly Trp  Gly Glu Arg Pro Leu  Gly Gly Ser Gly Gly  Ser Gly Gly 
    1400                 1405                 1410             


Ser Glu  Lys Pro Tyr Lys Cys  Pro Glu Cys Gly Lys  Ser Phe Ser 
    1415                 1420                 1425             


Ala Ser  Ala Ala Leu Val Ala  His Gln Arg Thr His  Thr Gly Glu 
    1430                 1435                 1440             


Lys Pro  Tyr Lys Cys Pro Glu  Cys Gly Lys Ser Phe  Ser Ala Ser 
    1445                 1450                 1455             


Ala Ala  Leu Val Ala His Gln  Arg Thr His Thr Gly  Glu Lys Pro 
    1460                 1465                 1470             


Tyr Lys  Cys Pro Glu Cys Gly  Lys Ser Phe Ser Ala  Ser Ala Ala 
    1475                 1480                 1485             


Leu Val  Ala His Gln Arg Thr  His Thr Gly 
    1490                 1495             


<210>  16
<211>  1333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys 
        35                  40                  45              


Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Val 
    50                  55                  60                  


Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp 
65                  70                  75                  80  


Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu 
                85                  90                  95      


Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser 
            100                 105                 110         


Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val 
        115                 120                 125             


Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu 
    130                 135                 140                 


Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile 
145                 150                 155                 160 


Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln 
                165                 170                 175     


Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly 
            180                 185                 190         


Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu 
        195                 200                 205             


Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg 
    210                 215                 220                 


Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp 
225                 230                 235                 240 


Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val 
                245                 250                 255     


Thr Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile 
            260                 265                 270         


Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr 
        275                 280                 285             


Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly 
    290                 295                 300                 


Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg 
305                 310                 315                 320 


Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys 
                325                 330                 335     


Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn 
            340                 345                 350         


Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe 
        355                 360                 365             


Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu 
    370                 375                 380                 


Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg 
385                 390                 395                 400 


Lys Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val 
                405                 410                 415     


Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr 
            420                 425                 430         


Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met 
        435                 440                 445             


Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys 
    450                 455                 460                 


Leu Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp 
465                 470                 475                 480 


Lys Gly Tyr Asn Lys Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn 
                485                 490                 495     


Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu 
            500                 505                 510         


Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu 
        515                 520                 525             


Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn 
    530                 535                 540                 


Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp 
545                 550                 555                 560 


Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn 
                565                 570                 575     


Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg 
            580                 585                 590         


Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 
        595                 600                 605             


Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 
    610                 615                 620                 


Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe 
625                 630                 635                 640 


Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser 
                645                 650                 655     


Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro 
            660                 665                 670         


Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp 
        675                 680                 685             


Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe 
    690                 695                 700                 


Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser 
705                 710                 715                 720 


Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 
                725                 730                 735     


Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr 
            740                 745                 750         


Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 
        755                 760                 765             


Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile 
    770                 775                 780                 


Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn 
785                 790                 795                 800 


Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys 
                805                 810                 815     


Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr 
            820                 825                 830         


Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe 
        835                 840                 845             


Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg 
    850                 855                 860                 


Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn 
865                 870                 875                 880 


Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn 
                885                 890                 895     


Gln Arg Leu Leu Ser Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn 
            900                 905                 910         


Thr Ser Ile Leu Asn Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu 
        915                 920                 925             


Ser Arg Tyr Ala Ser Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp 
    930                 935                 940                 


Pro Ile Asp Lys Asn Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys 
945                 950                 955                 960 


Ile Glu Val Ile Leu Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu 
                965                 970                 975     


Asn Phe Ser Thr Ser Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser 
            980                 985                 990         


Ile Ser Leu Asn Asn Glu Tyr Thr  Ile Ile Asn Cys Met  Glu Asn Asn 
        995                 1000                 1005             


Ser Gly  Trp Lys Val Ser Leu  Asn Tyr Gly Glu Ile  Ile Trp Thr 
    1010                 1015                 1020             


Leu Gln  Asp Thr Gln Glu Ile  Lys Gln Arg Val Val  Phe Lys Tyr 
    1025                 1030                 1035             


Ser Gln  Met Ile Asn Ile Ser  Asp Tyr Ile Asn Arg  Trp Ile Phe 
    1040                 1045                 1050             


Val Thr  Ile Thr Asn Asn Arg  Leu Asn Asn Ser Lys  Ile Tyr Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Ile Asp Gln  Lys Pro Ile Ser Asn  Leu Gly Asn 
    1070                 1075                 1080             


Ile His  Ala Ser Asn Asn Ile  Met Phe Lys Leu Asp  Gly Cys Arg 
    1085                 1090                 1095             


Asp Thr  His Arg Tyr Ile Trp  Ile Lys Tyr Phe Asn  Leu Phe Asp 
    1100                 1105                 1110             


Lys Glu  Leu Asn Glu Lys Glu  Ile Lys Asp Leu Tyr  Asp Asn Gln 
    1115                 1120                 1125             


Ser Asn  Ser Gly Ile Leu Lys  Asp Phe Trp Gly Asp  Tyr Leu Gln 
    1130                 1135                 1140             


Tyr Asp  Lys Pro Tyr Tyr Met  Leu Asn Leu Tyr Asp  Pro Asn Lys 
    1145                 1150                 1155             


Tyr Val  Asp Val Asn Asn Val  Gly Ile Arg Gly Tyr  Met Tyr Leu 
    1160                 1165                 1170             


Lys Gly  Pro Arg Gly Ser Val  Met Thr Thr Asn Ile  Tyr Leu Asn 
    1175                 1180                 1185             


Ser Ser  Leu Tyr Arg Gly Thr  Lys Phe Ile Ile Lys  Lys Tyr Ala 
    1190                 1195                 1200             


Ser Gly  Asn Lys Asp Asn Ile  Val Arg Asn Asn Asp  Arg Val Tyr 
    1205                 1210                 1215             


Ile Asn  Val Val Val Lys Asn  Lys Glu Tyr Arg Leu  Ala Thr Asn 
    1220                 1225                 1230             


Ala Ser  Gln Ala Gly Val Glu  Lys Ile Leu Ser Ala  Leu Glu Ile 
    1235                 1240                 1245             


Pro Asp  Val Gly Asn Leu Ser  Gln Val Val Val Met  Lys Ser Lys 
    1250                 1255                 1260             


Asn Asp  Gln Gly Ile Thr Asn  Lys Cys Lys Met Asn  Leu Gln Asp 
    1265                 1270                 1275             


Asn Asn  Gly Asn Asp Ile Gly  Phe Ile Gly Phe His  Gln Phe Asn 
    1280                 1285                 1290             


Asn Ile  Ala Lys Leu Val Ala  Ser Asn Trp Tyr Asn  Arg Gln Ile 
    1295                 1300                 1305             


Glu Arg  Ser Ser Arg Thr Leu  Gly Cys Ser Trp Glu  Phe Ile Pro 
    1310                 1315                 1320             


Val Asp  Asp Gly Trp Gly Glu  Arg Pro Leu 
    1325                 1330             


<210>  17
<211>  1342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met His His His His His His Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
            20                  25                  30          


Lys Lys Arg Lys Val Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Pro 
        35                  40                  45              


Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp 
    50                  55                  60                  


Ile Ala Tyr Ile Lys Ile Pro Asn Val Gly Gln Met Gln Pro Val Lys 
65                  70                  75                  80  


Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr 
                85                  90                  95      


Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys 
            100                 105                 110         


Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn 
        115                 120                 125             


Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile 
    130                 135                 140                 


Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly 
145                 150                 155                 160 


Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile 
                165                 170                 175     


Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser 
            180                 185                 190         


Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln 
        195                 200                 205             


Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn 
    210                 215                 220                 


Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe 
225                 230                 235                 240 


Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala 
                245                 250                 255     


Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile 
            260                 265                 270         


His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val 
        275                 280                 285             


Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val 
    290                 295                 300                 


Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile 
305                 310                 315                 320 


Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe 
                325                 330                 335     


Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr 
            340                 345                 350         


Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu 
        355                 360                 365             


Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe 
    370                 375                 380                 


Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe 
385                 390                 395                 400 


Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp 
                405                 410                 415     


Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile 
            420                 425                 430         


Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn 
        435                 440                 445             


Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn 
    450                 455                 460                 


Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile 
465                 470                 475                 480 


Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys Ala Leu 
                485                 490                 495     


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
            500                 505                 510         


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
        515                 520                 525             


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
    530                 535                 540                 


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
545                 550                 555                 560 


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
                565                 570                 575     


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
            580                 585                 590         


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
        595                 600                 605             


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
    610                 615                 620                 


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
625                 630                 635                 640 


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
                645                 650                 655     


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
            660                 665                 670         


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
        675                 680                 685             


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
    690                 695                 700                 


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
705                 710                 715                 720 


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
                725                 730                 735     


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
            740                 745                 750         


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
        755                 760                 765             


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
    770                 775                 780                 


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
785                 790                 795                 800 


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
                805                 810                 815     


Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys 
            820                 825                 830         


Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro 
        835                 840                 845             


Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala 
    850                 855                 860                 


Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 
865                 870                 875                 880 


Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro 
                885                 890                 895     


Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe 
            900                 905                 910         


Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg 
        915                 920                 925             


Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser Lys Ile 
    930                 935                 940                 


Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn Gln Ile 
945                 950                 955                 960 


Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu Lys Asn 
                965                 970                 975     


Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe Trp 
            980                 985                 990         


Ile Arg Ile Pro Lys Tyr Phe Asn  Ser Ile Ser Leu Asn  Asn Glu Tyr 
        995                 1000                 1005             


Thr Ile  Ile Asn Cys Met Glu  Asn Asn Ser Gly Trp  Lys Val Ser 
    1010                 1015                 1020             


Leu Asn  Tyr Gly Glu Ile Ile  Trp Thr Leu Gln Asp  Thr Gln Glu 
    1025                 1030                 1035             


Ile Lys  Gln Arg Val Val Phe  Lys Tyr Ser Gln Met  Ile Asn Ile 
    1040                 1045                 1050             


Ser Asp  Tyr Ile Asn Arg Trp  Ile Phe Val Thr Ile  Thr Asn Asn 
    1055                 1060                 1065             


Arg Leu  Asn Asn Ser Lys Ile  Tyr Ile Asn Gly Arg  Leu Ile Asp 
    1070                 1075                 1080             


Gln Lys  Pro Ile Ser Asn Leu  Gly Asn Ile His Ala  Ser Asn Asn 
    1085                 1090                 1095             


Ile Met  Phe Lys Leu Asp Gly  Cys Arg Asp Thr His  Arg Tyr Ile 
    1100                 1105                 1110             


Trp Ile  Lys Tyr Phe Asn Leu  Phe Asp Lys Glu Leu  Asn Glu Lys 
    1115                 1120                 1125             


Glu Ile  Lys Asp Leu Tyr Asp  Asn Gln Ser Asn Ser  Gly Ile Leu 
    1130                 1135                 1140             


Lys Asp  Phe Trp Gly Asp Tyr  Leu Gln Tyr Asp Lys  Pro Tyr Tyr 
    1145                 1150                 1155             


Met Leu  Asn Leu Tyr Asp Pro  Asn Lys Tyr Val Asp  Val Asn Asn 
    1160                 1165                 1170             


Val Gly  Ile Arg Gly Tyr Met  Tyr Leu Lys Gly Pro  Arg Gly Ser 
    1175                 1180                 1185             


Val Met  Thr Thr Asn Ile Tyr  Leu Asn Ser Ser Leu  Tyr Arg Gly 
    1190                 1195                 1200             


Thr Lys  Phe Ile Ile Lys Lys  Tyr Ala Ser Gly Asn  Lys Asp Asn 
    1205                 1210                 1215             


Ile Val  Arg Asn Asn Asp Arg  Val Tyr Ile Asn Val  Val Val Lys 
    1220                 1225                 1230             


Asn Lys  Glu Tyr Arg Leu Ala  Thr Asn Ala Ser Gln  Ala Gly Val 
    1235                 1240                 1245             


Glu Lys  Ile Leu Ser Ala Leu  Glu Ile Pro Asp Val  Gly Asn Leu 
    1250                 1255                 1260             


Ser Gln  Val Val Val Met Lys  Ser Lys Asn Asp Gln  Gly Ile Thr 
    1265                 1270                 1275             


Asn Lys  Cys Lys Met Asn Leu  Gln Asp Asn Asn Gly  Asn Asp Ile 
    1280                 1285                 1290             


Gly Phe  Ile Gly Phe His Gln  Phe Asn Asn Ile Ala  Lys Leu Val 
    1295                 1300                 1305             


Ala Ser  Asn Trp Tyr Asn Arg  Gln Ile Glu Arg Ser  Ser Arg Thr 
    1310                 1315                 1320             


Leu Gly  Cys Ser Trp Glu Phe  Ile Pro Val Asp Asp  Gly Trp Gly 
    1325                 1330                 1335             


Glu Arg  Pro Leu 
    1340         


<210>  18
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      


Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          


Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              


Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  


Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  


Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         


Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             


Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 


Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 


Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     


Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         


Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             


His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 


Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 


Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     


Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         


Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             


Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 


Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
    450                 455                 460                 


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
465                 470                 475                 480 


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
                485                 490                 495     


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
            500                 505                 510         


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
        515                 520                 525             


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
    530                 535                 540                 


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
545                 550                 555                 560 


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
                565                 570                 575     


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
            580                 585                 590         


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
        595                 600                 605             


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
    610                 615                 620         


<210>  19
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Lys His Ser Leu Pro Asp Leu Pro Tyr Asp Tyr Gly Ala Leu Glu 
1               5                   10                  15      


Pro His Ile Asn Ala Gln Ile Met Gln Leu His His Ser Lys His His 
            20                  25                  30          


Ala Ala Tyr Val Asn Asn Leu Asn Val Thr Glu Glu Lys Tyr Gln Glu 
        35                  40                  45              


Ala Leu Ala Lys Gly Asp Val Thr Ala Gln Ile Ala Leu Gln Pro Ala 
    50                  55                  60                  


Leu Lys Phe Asn Gly Gly Gly His Ile Asn His Ser Ile Phe Trp Thr 
65                  70                  75                  80  


Asn Leu Ser Pro Asn Gly Gly Gly Glu Pro Lys Gly Glu Leu Leu Glu 
                85                  90                  95      


Ala Ile Lys Arg Asp Phe Gly Ser Phe Asp Lys Phe Lys Glu Lys Leu 
            100                 105                 110         


Thr Ala Ala Ser Val Gly Val Gln Gly Ser Gly Trp Gly Trp Leu Gly 
        115                 120                 125             


Phe Asn Lys Glu Arg Gly His Leu Gln Ile Ala Ala Cys Pro Asn Gln 
    130                 135                 140                 


Asp Pro Leu Gln Gly Thr Thr Gly Leu Ile Pro Leu Leu Gly Ile Asp 
145                 150                 155                 160 


Val Trp Glu His Ala Tyr Tyr Leu Gln Tyr Lys Asn Val Arg Pro Asp 
                165                 170                 175     


Tyr Leu Lys Ala Ile Trp Asn Val Ile Asn Trp Glu Asn Val Thr Glu 
            180                 185                 190         


Arg Tyr Met Ala Cys Lys Lys 
        195                 


