﻿                         序列表

<110>  厦门大学
       养生堂有限公司
 
<120>  一种用于治疗肿瘤的病毒

<130>  IEC170083PCT

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  7383
<212>  DNA
<213>  人工序列

<220>
<223>  EV-D68-WT的cDNA序列

<400>  1
taatacgact cactataggt taaaacagcc ttggggttgt tcccactcca agggcccacg       60

tggcggctag tactctggta cttcggtacc tttgtacgcc tgttttatct cccttcccaa      120

tgtaacttag aagttcttaa atcaatgctc aataggtggg gcgcaaacca gcgctctcat      180

gagcaagcac tcctgtctcc ccggtgaggt tgtataaact gttcccacgg ttgaaaacaa      240

cctatccgtt atccgctata gtacttcgag aaacctagta ccacctttgg attgttgacg      300

cgttgcgctc agcacactaa cccgtgtgta gcttgggtcg atgagtctgg acatacctca      360

ctggcgacag tggtccaggc tgcgttggcg gcctactcat ggtgaaagcc atgagacgct      420

agacatgaac aaggtgtgaa gagtctattg agctactata gagtcctccg gcccctgaat      480

gcggctaatc ctaaccatgg agcaagtgct cacaggccag tgagttgctt gtcgtaatgc      540

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttcacttttt acttttatga      600

ctgcttatgg tgacaatttg atattgttac catttagctt gtcaaatcaa ttgcaaaaga      660

tcctaaatct tatttatcaa cttgcatctt gataacttta atttgaaaat tttaacaatg      720

ggagctcagg ttactagaca acaaactggc actcatgaaa atgccaacat tgccacaaat      780

ggatctcata tcacatacaa tcagataaac ttttacaagg atagctatgc ggcttcagcc      840

agcaagcagg atttttcaca ggacccatca aaattcactg aaccagtagt ggaaggttta      900

aaagcagggg cgccagtttt gaaatctcct agtgctgagg catgtggcta cagtgataga      960

gtattacagc tcaaattagg aaattcagct attgtcaccc aggaagcagc gaactactgc     1020

tgcgcttatg gtgaatggcc caattactta ccagaccatg aagcagtagc cattgataaa     1080

cctacacaac cagaaactgc tacagataga ttctacactt tgaaatcagt caaatgggaa     1140

actggaagca caggatggtg gtggaaacta cccgatgcac tgaataatat aggcatgttt     1200

ggacagaatg tgcagcatca ctacctatat agatctggtt tcttgattca tgtgcagtgt     1260

aatgccacaa aattccatca aggtgcctta ttagtggtag caattccaga acatcagagg     1320

ggagcgcaca acaccaacac tagcccaggg tttgatgata taatgaaagg tgaagaagga     1380

gggaccttca atcatccata tgtccttgat gatggaacat cattggcttg tgcgacgata     1440

tttccacatc agtggataaa tctgagaacc aacaattcag caacaattgt tcttccctgg     1500

atgaatgctg ctccaatgga tttcccactt agacataatc agtggacgct agcaataata     1560

ccagtggtgc cattaggtac gcgtacaaca tcaagtatgg tcccaataac agtttcaatc     1620

gctccaatgt gttgtgagtt taatggactt agacacgcca ttactcaagg tgtcccaaca     1680

taccttttac caggctcggg acaattccta acaactgatg atcatagctc tgcaccagct     1740

ctcccgtgtt tcaacccaac tccagaaatg catatcccag ggcaggtccg taacatgcta     1800

gaagtggtcc aagtggaatc aatgatggag attaataaca cagaaagtgc agttggcatg     1860

gagcgtctta aggttgatat atcagcattg acagatgtcg atcaattgtt attcaacatt     1920

ccactggaca tacagttgga tgggccactt agaaacactt tggtaggaaa catatctaga     1980

tattacactc attggtctgg atccctagaa atgacgttta tgttttgtgg cagcttcatg     2040

gcaacgggaa aattaatcct gtgctatact cctccaggtg gatcatgccc gacaaccaga     2100

gagaccgcca tgttaggtac acatattgtt tgggattttg gattacaatc tagtgtaacc     2160

ctgataatac cttggattag tggatcccac tacaggatgt ttaataatga tgctaagtca     2220

actaatgcca acgttggcta tgtcacttgt tttatgcaga ccaatctgat agtccccagt     2280

gaatcctctg acacgtgttc cttgataggg ttcatagcag caaaagatga tttctccctc     2340

agattaatga gagacagccc tgacattgga caactagacc atttacatgc agcagaggca     2400

gcctaccaga tcgagagcat catcaaaaca gcgaccgaca ctgtgaaaag tgagattaat     2460

gctgaacttg gtgtggtccc tagcttaaat gcagttgaaa caggtgcaac ttctaacact     2520

gaaccagaag aagccataca aactcgcaca gtgataaatc agcacggtgt atccgagact     2580

ctagtggaga attttctcag tagagcagct ttggtatcaa agagaagttt tgaatacaaa     2640

gatcatactt cgtctgcagc acaagcagac aagaactttt tcaaatggac aattaacacc     2700

agatcctttg tacagttaag aagaaaatta gaattattca cataccttag atttgatgct     2760

gagatcacta tactcacaac tgtagcagtg aatggtagtg gtaataatac atacgtgggt     2820

cttcctgact tgacactcca agcaatgttt gtacccactg gtgctcttac cccagaaaaa     2880

caggactcat tccactggca gtcaggcagt aatgctagtg tattctttaa aatctccgac     2940

cccccagcca gaataaccat accttttatg tgcattaact cagcatactc agttttttat     3000

gatggctttg ccggatttga gaaaaacggt ctgtatggaa taaatccagc tgacactatt     3060

ggtaacttat gtgttagaat agtgaatgaa caccaaccag ttggtttcac agtgaccgtt     3120

agggtttaca tgaagcctaa acacataaaa gcatgggcac cacgaccacc acgaactttg     3180

ccatatatga gtattgcaaa tgcaaattac aaaggtaaag aaagagcacc aaatgcgctc     3240

aatgctataa ttggcaatag agacagtgtc aaaaccatgc ctcataatat agtgaacact     3300

ggtccaggct tcggaggagt ttttgtaggg tctttcaaaa taatcaacta tcacttggcc     3360

actacagaag agagacagtc agctatctat gtggattggc aatcagacgt cttggttacc     3420

cccattgctg ctcatggaag gcaccaaata gcaagatgca agtgcaacac aggggtttac     3480

tattgtaggc acaaaaacag aagttacccg atttgctttg aaggcccagg gattcaatgg     3540

attgaacaaa atgaatatta cccagcaagg taccagacca atgtactatt ggcagttggt     3600

cctgcggaag caggagattg cggtggttta ctagtttgtc cacatggggt aatcggtctt     3660

cttacagcag gagggggtgg aattgtagct ttcactgata tcaggaattt gctatggtta     3720

gatactgatg ctatggaaca aggcattact gattatattc aaaatcttgg taatgccttt     3780

ggagcaggat ttacagaaac aatctctaat aaagccaagg aagtgcaaga tatgctaatt     3840

ggagagagtt cactattaga aaaattgtta aaagctctaa tcaaaatcat atcagcatta     3900

gtaattgtaa tcagaaactc agaagattta gtcacagtca cagccacact agcattgttg     3960

ggatgccatg attcaccatg gagctacttg aaacagaagg tatgttcata cttaggtatt     4020

ccttatgtac ctagacaggg tgaatcgtgg cttaagaaat tcacagaggc atgcaatgct     4080

cttagaggtc tggattggct atcgcaaaag atagataaat tcatcaactg gcttaaaacc     4140

aaaatattac cagaagctag ggagaaatat gaatttgtgc aaaggctcaa acagttaccg     4200

gtgatagaaa accaagttag tacaatcgag catagctgcc caacaacaga acaacaacag     4260

gccttattca acaacgtcca atactattca cactactgta gaaagtacgc accactttac     4320

gcagtggaag caaagagggt agtagctctt gaaaagaaaa taaacaacta catccagttc     4380

aagtccaaat ctcgcattga accggtttgt ttaataatac atggctctcc aggaactggc     4440

aagtcagtgg cttcaaattt aattgccagg gctatcacag agaaattggg gggggacatt     4500

tattccttgc ctccagaccc taaatatttt gatggataca aacagcaaac agtggtcctc     4560

atggatgatt taatgcaaaa tccagatggg aatgacatat ctatgttctg ccaaatggtc     4620

tccactgtag atttcatacc cccaatggct agtttggagg aaaaaggaac tctatacacc     4680

agtccatttt taatagctac taccaatgct ggctcaatac atgcaccaac tgtatcagac     4740

tcaaaggctt tgtcacgcag atttaaattt gacgtggaca ttgaagtcac agattcatac     4800

aaggactcaa ataaattgga tatgtcaagg gcagtcgaga tgtgcaaacc agatggctgt     4860

gcccccacca attacaaaag atgctgccca ttgatctgtg gaaaggctat ccaattcaga     4920

gatcgcagaa ctaatgcaag atccactatt gatatgctag taactgatat tataaaggaa     4980

tatagaacca gaaacagtac acaggataag ctggaagctc tgtttcaggg gcctccacag     5040

tttaaagaga tcaaaatttc agtcacccca gatacaccag ctcctgatgc tataaatgac     5100

cttcttaggt cagtggattc tcaagaagtt agggattatt gccaaaagaa aggatggatt     5160

gtagtacacc catcaaatga gctaatagta gaaaaacaca ttagtagagc ttttattact     5220

ctacaagcca ttgccacctt tgtatcaata gctggtgtag tttatgttat atacaaactt     5280

tttgctggca ttcagggtcc atacacagga atccccaatc ctaaacctaa agtaccctct     5340

ctcagaacag ctaaagtgca aggaccaggg ttcgattttg cacaagccat aatgaagaaa     5400

aataccgtca ttgcaaggac tgaaaagggt gagttcacca tgctgggtgt atatgatagg     5460

gtagcggtca tccccacaca cgcatctgtt ggagaaacca tttacattaa tgatgtagag     5520

actaaagttt tagatgcgtg tgcacttaga gacttgactg atacaaactt agagataacc     5580

atagtcaaat tagaccgtaa tcaaaaattt agagatatca gacattttct gcccagatat     5640

gaggatgatt acaatgacgc tgtgcttagc gtacatacat caaaattccc aaatatgtat     5700

atcccagttg gacaagtcac caattatggc ttcttgaacc taggtggtac accgacgcac     5760

cgcattttaa tgtataactt cccaacaaga gctggccagt gtggtggtgt ggtgacaact     5820

acaggtaagg tgataggaat acatgtaggt ggaaatggag ctcaaggatt tgcagcaatg     5880

ctactacact cttacttttc cgatacacaa ggtgagatag ttagtagtga aaagagtggg     5940

gtgtgcatta acgcaccggc aaagactaaa ctccaaccta gtgttttcca tcaagttttt     6000

gaaggttcaa aggaaccagc agttctcaat ccaaaagatc ctaggcttaa aacagatttc     6060

gaggaggcca ttttctcaaa gtacacaggt aacaaaatta tgttaatgga tgagtacatg     6120

gaagaggcag tggatcatta tgtggggtgt ttagaaccat tagacatcag tgtggatccc     6180

atacccctgg aaagtgccat gtatggaatg gatggccttg aggcattaga cttaactacc     6240

agtgcaggat tcccttactt actacaaggg aagaagaaaa gggatatatt taatagacat     6300

actagagaca ccagtgaaat gacaaaaatg ttagagaaat atggagttga cctacctttt     6360

gtaacctttg taaaagatga gcttagatca agagaaaaag ttgaaaaagg gaaatcacgc     6420

ctgattgagg ccagttcctt gaatgactca gttgctatga gagttgcctt tggaaacctt     6480

tacgccacat ttcacaacaa tccaggtaca gcaactggta gtgcagttgg ttgtgatcca     6540

gatatatttt ggtcaaaaat ccctattttg ttagatggag aaatctttgc ttttgactac     6600

actggttatg atgctagttt gtcaccagtg tggtttgcct gcttaaagaa agttctaatt     6660

aagttaggtt acacacatca aacgtctttt atagattatt tgtgtcattc agtacattta     6720

tataaggaca aaaaatacat agttaatggt ggaatgccct ctggttcttc aggcaccagc     6780

atattcaaca ctatgatcaa caatataatc ataagaactt tattaattag ggtttacaaa     6840

ggcatagacc tggaccagtt caaaatgatt gcctatgggg atgatgttat tgctagctac     6900

ccacataaga ttgatccagg tttgctggca gaagcaggta aacagtatgg attagtaatg     6960

acgccagcag acaaaggaac cagttttatt gacacaaatt gggaaaatgt aactttctta     7020

aaaagatatt tcagagcaga tgatcaatac ccctttctca tacatccagt gatgccaatg     7080

aaagagatac atgaatctat tagatggact aaagatccca gaaacacaca ggatcatgtt     7140

aggtctttgt gctacctcgc atggcataat ggagaggagg cttataatga attttgcaga     7200

aaaatcagaa gtgtgcctgt gggaagagca ttgacactac ctgcatactc tagtcttaga     7260

cggaaatggt tagattcgtt ctagacaact ctaattgaaa cccaagttat agttactttc     7320

atttagaggt aaattttggt cacttggggg ccaaaaaaaa aaaaaaaaaa aaaaaaagtc     7380

gac                                                                   7383


<210>  2
<211>  507
<212>  RNA
<213>  人工序列

<220>
<223>  HRV2的内部核糖体进入位点序列的RNA序列

<400>  2
aacuuagaag uuuuucacaa agaccaauag ccgguaauca gccagauuac ugaaggucaa       60

gcacuucugu uuccccgguc aauguugaua ugcuccaaca gggcaaaaac aacugcgauc      120

guuaaccgca aagcgccuac gcaaagcuua guagcaucuu ugaaaucguu uggcuggucg      180

auccgccauu uccccuggua gaccuggcag augaggcuag aaauacccca cuggcgacag      240

uguucuagcc ugcguggcug ccugcacacc cuaugggugu gaagccaaac aauggacaag      300

gugugaagag ccccgugugc ucgcuuugag uccuccggcc ccugaaugug gcuaaccuua      360

acccugcagc uagagcacgu aacccaaugu guaucuaguc guaaugagca auugcgggau      420

gggaccaacu acuuugggug uccguguuuc acuuuuuccu uuauauuugc uuauggugac      480

aauauauaca auauauauau uggcacc                                          507


<210>  3
<211>  22
<212>  RNA
<213>  人工序列

<220>
<223>  miR-133靶序列的RNA序列

<400>  3
acagcugguu gaaggggacc aa                                                22


<210>  4
<211>  22
<212>  RNA
<213>  人工序列

<220>
<223>  miR-206靶序列的RNA序列

<400>  4
ccacacacuu ccuuacauuc ca                                                22


<210>  5
<211>  102
<212>  RNA
<213>  人工序列

<220>
<223>  miR-133靶序列与miR-206靶序列的串联序列的RNA序列

<400>  5
acagcugguu gaaggggacc aacgauacag cugguugaag gggaccaaac cgguccacac       60

acuuccuuac auuccaucac ccacacacuu ccuuacauuc ca                         102


<210>  6
<211>  435
<212>  DNA
<213>  人工序列

<220>
<223>  GM-CSF基因DNA序列

<400>  6
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  7
<211>  795
<212>  DNA
<213>  人工序列

<220>
<223>  编码Anti-PD-1 scFv的DNA序列

<400>  7
atgaagcacc tgtggttctt cctgctgctg gtggccgctc ctaggtgggt gctgtcccag       60

gtgcagctgg tgcagagcgg cgtggaggtg aagaagcccg gcgcttccgt gaaggtgtcc      120

tgcaaggcct ccggctacac cttcaccaac tactacatgt actgggtgag gcaggcccct      180

ggacagggac tggagtggat gggcggcatc aacccttcca acggcggcac caacttcaac      240

gagaagttca agaaccgggt gaccctgacc accgactcct ccaccaccac cgcctacatg      300

gagctgaagt ccctgcagtt tgacgacacc gccgtgtact actgcgccag gagggactac      360

cggttcgaca tgggcttcga ctactggggc cagggcacaa ccgtgaccgt gtccagcgga      420

ggtggcggat ctggaggggg tggtagcggt ggaggcggga gtgagatcgt gctgacccag      480

tcccctgcta cactgtccct gtcccccggc gagagggcta cactgagctg cagggcctcc      540

aagggcgtgt ccacctccgg ctactcctac ctgcactggt accagcagaa gcctggacag      600

gctcccaggc tgctgatcta cctggcctcc tacctggagt ccggcgtgcc tgctaggttt      660

tccggcagcg gcagcggcac cgatttcacc ctgaccatct cctccctgga gcccgaggac      720

ttcgccgtgt actactgcca gcactccagg gatctgcctc tgaccttcgg cggcggcacc      780

aaggtggaga tcaag                                                       795


<210>  8
<211>  7306
<212>  DNA
<213>  人工序列

<220>
<223>  EV-D68-HRV2的cDNA序列

<400>  8
taatacgact cactataggt taaaacagcc ttggggttgt tcccactcca agggcccacg       60

tggcggctag tactctggta cttcggtacc tttgtacgcc tgttttatct cccttcccaa      120

tgtaacttag aagaacttag aagtttttca caaagaccaa tagccggtaa tcagccagat      180

tactgaaggt caagcacttc tgtttccccg gtcaatgttg atatgctcca acagggcaaa      240

aacaactgcg atcgttaacc gcaaagcgcc tacgcaaagc ttagtagcat ctttgaaatc      300

gtttggctgg tcgatccgcc atttcccctg gtagacctgg cagatgaggc tagaaatacc      360

ccactggcga cagtgttcta gcctgcgtgg ctgcctgcac accctatggg tgtgaagcca      420

aacaatggac aaggtgtgaa gagccccgtg tgctcgcttt gagtcctccg gcccctgaat      480

gtggctaacc ttaaccctgc agctagagca cgtaacccaa tgtgtatcta gtcgtaatga      540

gcaattgcgg gatgggacca actactttgg gtgtccgtgt ttcacttttt cctttatatt      600

tgcttatggt gacaatatat acaatatata tattggcacc atgggagctc aggttactag      660

acaacaaact ggcactcatg aaaatgccaa cattgccaca aatggatctc atatcacata      720

caatcagata aacttttaca aggatagcta tgcggcttca gccagcaagc aggatttttc      780

acaggaccca tcaaaattca ctgaaccagt agtggaaggt ttaaaagcag gggcgccagt      840

tttgaaatct cctagtgctg aggcatgtgg ctacagtgat agagtattac agctcaaatt      900

aggaaattca gctattgtca cccaggaagc agcgaactac tgctgcgctt atggtgaatg      960

gcccaattac ttaccagacc atgaagcagt agccattgat aaacctacac aaccagaaac     1020

tgctacagat agattctaca ctttgaaatc agtcaaatgg gaaactggaa gcacaggatg     1080

gtggtggaaa ctacccgatg cactgaataa tataggcatg tttggacaga atgtgcagca     1140

tcactaccta tatagatctg gtttcttgat tcatgtgcag tgtaatgcca caaaattcca     1200

tcaaggtgcc ttattagtgg tagcaattcc agaacatcag aggggagcgc acaacaccaa     1260

cactagccca gggtttgatg atataatgaa aggtgaagaa ggagggacct tcaatcatcc     1320

atatgtcctt gatgatggaa catcattggc ttgtgcgacg atatttccac atcagtggat     1380

aaatctgaga accaacaatt cagcaacaat tgttcttccc tggatgaatg ctgctccaat     1440

ggatttccca cttagacata atcagtggac gctagcaata ataccagtgg tgccattagg     1500

tacgcgtaca acatcaagta tggtcccaat aacagtttca atcgctccaa tgtgttgtga     1560

gtttaatgga cttagacacg ccattactca aggtgtccca acataccttt taccaggctc     1620

gggacaattc ctaacaactg atgatcatag ctctgcacca gctctcccgt gtttcaaccc     1680

aactccagaa atgcatatcc cagggcaggt ccgtaacatg ctagaagtgg tccaagtgga     1740

atcaatgatg gagattaata acacagaaag tgcagttggc atggagcgtc ttaaggttga     1800

tatatcagca ttgacagatg tcgatcaatt gttattcaac attccactgg acatacagtt     1860

ggatgggcca cttagaaaca ctttggtagg aaacatatct agatattaca ctcattggtc     1920

tggatcccta gaaatgacgt ttatgttttg tggcagcttc atggcaacgg gaaaattaat     1980

cctgtgctat actcctccag gtggatcatg cccgacaacc agagagaccg ccatgttagg     2040

tacacatatt gtttgggatt ttggattaca atctagtgta accctgataa taccttggat     2100

tagtggatcc cactacagga tgtttaataa tgatgctaag tcaactaatg ccaacgttgg     2160

ctatgtcact tgttttatgc agaccaatct gatagtcccc agtgaatcct ctgacacgtg     2220

ttccttgata gggttcatag cagcaaaaga tgatttctcc ctcagattaa tgagagacag     2280

ccctgacatt ggacaactag accatttaca tgcagcagag gcagcctacc agatcgagag     2340

catcatcaaa acagcgaccg acactgtgaa aagtgagatt aatgctgaac ttggtgtggt     2400

ccctagctta aatgcagttg aaacaggtgc aacttctaac actgaaccag aagaagccat     2460

acaaactcgc acagtgataa atcagcacgg tgtatccgag actctagtgg agaattttct     2520

cagtagagca gctttggtat caaagagaag ttttgaatac aaagatcata cttcgtctgc     2580

agcacaagca gacaagaact ttttcaaatg gacaattaac accagatcct ttgtacagtt     2640

aagaagaaaa ttagaattat tcacatacct tagatttgat gctgagatca ctatactcac     2700

aactgtagca gtgaatggta gtggtaataa tacatacgtg ggtcttcctg acttgacact     2760

ccaagcaatg tttgtaccca ctggtgctct taccccagaa aaacaggact cattccactg     2820

gcagtcaggc agtaatgcta gtgtattctt taaaatctcc gaccccccag ccagaataac     2880

catacctttt atgtgcatta actcagcata ctcagttttt tatgatggct ttgccggatt     2940

tgagaaaaac ggtctgtatg gaataaatcc agctgacact attggtaact tatgtgttag     3000

aatagtgaat gaacaccaac cagttggttt cacagtgacc gttagggttt acatgaagcc     3060

taaacacata aaagcatggg caccacgacc accacgaact ttgccatata tgagtattgc     3120

aaatgcaaat tacaaaggta aagaaagagc accaaatgcg ctcaatgcta taattggcaa     3180

tagagacagt gtcaaaacca tgcctcataa tatagtgaac actggtccag gcttcggagg     3240

agtttttgta gggtctttca aaataatcaa ctatcacttg gccactacag aagagagaca     3300

gtcagctatc tatgtggatt ggcaatcaga cgtcttggtt acccccattg ctgctcatgg     3360

aaggcaccaa atagcaagat gcaagtgcaa cacaggggtt tactattgta ggcacaaaaa     3420

cagaagttac ccgatttgct ttgaaggccc agggattcaa tggattgaac aaaatgaata     3480

ttacccagca aggtaccaga ccaatgtact attggcagtt ggtcctgcgg aagcaggaga     3540

ttgcggtggt ttactagttt gtccacatgg ggtaatcggt cttcttacag caggaggggg     3600

tggaattgta gctttcactg atatcaggaa tttgctatgg ttagatactg atgctatgga     3660

acaaggcatt actgattata ttcaaaatct tggtaatgcc tttggagcag gatttacaga     3720

aacaatctct aataaagcca aggaagtgca agatatgcta attggagaga gttcactatt     3780

agaaaaattg ttaaaagctc taatcaaaat catatcagca ttagtaattg taatcagaaa     3840

ctcagaagat ttagtcacag tcacagccac actagcattg ttgggatgcc atgattcacc     3900

atggagctac ttgaaacaga aggtatgttc atacttaggt attccttatg tacctagaca     3960

gggtgaatcg tggcttaaga aattcacaga ggcatgcaat gctcttagag gtctggattg     4020

gctatcgcaa aagatagata aattcatcaa ctggcttaaa accaaaatat taccagaagc     4080

tagggagaaa tatgaatttg tgcaaaggct caaacagtta ccggtgatag aaaaccaagt     4140

tagtacaatc gagcatagct gcccaacaac agaacaacaa caggccttat tcaacaacgt     4200

ccaatactat tcacactact gtagaaagta cgcaccactt tacgcagtgg aagcaaagag     4260

ggtagtagct cttgaaaaga aaataaacaa ctacatccag ttcaagtcca aatctcgcat     4320

tgaaccggtt tgtttaataa tacatggctc tccaggaact ggcaagtcag tggcttcaaa     4380

tttaattgcc agggctatca cagagaaatt ggggggggac atttattcct tgcctccaga     4440

ccctaaatat tttgatggat acaaacagca aacagtggtc ctcatggatg atttaatgca     4500

aaatccagat gggaatgaca tatctatgtt ctgccaaatg gtctccactg tagatttcat     4560

acccccaatg gctagtttgg aggaaaaagg aactctatac accagtccat ttttaatagc     4620

tactaccaat gctggctcaa tacatgcacc aactgtatca gactcaaagg ctttgtcacg     4680

cagatttaaa tttgacgtgg acattgaagt cacagattca tacaaggact caaataaatt     4740

ggatatgtca agggcagtcg agatgtgcaa accagatggc tgtgccccca ccaattacaa     4800

aagatgctgc ccattgatct gtggaaaggc tatccaattc agagatcgca gaactaatgc     4860

aagatccact attgatatgc tagtaactga tattataaag gaatatagaa ccagaaacag     4920

tacacaggat aagctggaag ctctgtttca ggggcctcca cagtttaaag agatcaaaat     4980

ttcagtcacc ccagatacac cagctcctga tgctataaat gaccttctta ggtcagtgga     5040

ttctcaagaa gttagggatt attgccaaaa gaaaggatgg attgtagtac acccatcaaa     5100

tgagctaata gtagaaaaac acattagtag agcttttatt actctacaag ccattgccac     5160

ctttgtatca atagctggtg tagtttatgt tatatacaaa ctttttgctg gcattcaggg     5220

tccatacaca ggaatcccca atcctaaacc taaagtaccc tctctcagaa cagctaaagt     5280

gcaaggacca gggttcgatt ttgcacaagc cataatgaag aaaaataccg tcattgcaag     5340

gactgaaaag ggtgagttca ccatgctggg tgtatatgat agggtagcgg tcatccccac     5400

acacgcatct gttggagaaa ccatttacat taatgatgta gagactaaag ttttagatgc     5460

gtgtgcactt agagacttga ctgatacaaa cttagagata accatagtca aattagaccg     5520

taatcaaaaa tttagagata tcagacattt tctgcccaga tatgaggatg attacaatga     5580

cgctgtgctt agcgtacata catcaaaatt cccaaatatg tatatcccag ttggacaagt     5640

caccaattat ggcttcttga acctaggtgg tacaccgacg caccgcattt taatgtataa     5700

cttcccaaca agagctggcc agtgtggtgg tgtggtgaca actacaggta aggtgatagg     5760

aatacatgta ggtggaaatg gagctcaagg atttgcagca atgctactac actcttactt     5820

ttccgataca caaggtgaga tagttagtag tgaaaagagt ggggtgtgca ttaacgcacc     5880

ggcaaagact aaactccaac ctagtgtttt ccatcaagtt tttgaaggtt caaaggaacc     5940

agcagttctc aatccaaaag atcctaggct taaaacagat ttcgaggagg ccattttctc     6000

aaagtacaca ggtaacaaaa ttatgttaat ggatgagtac atggaagagg cagtggatca     6060

ttatgtgggg tgtttagaac cattagacat cagtgtggat cccatacccc tggaaagtgc     6120

catgtatgga atggatggcc ttgaggcatt agacttaact accagtgcag gattccctta     6180

cttactacaa gggaagaaga aaagggatat atttaataga catactagag acaccagtga     6240

aatgacaaaa atgttagaga aatatggagt tgacctacct tttgtaacct ttgtaaaaga     6300

tgagcttaga tcaagagaaa aagttgaaaa agggaaatca cgcctgattg aggccagttc     6360

cttgaatgac tcagttgcta tgagagttgc ctttggaaac ctttacgcca catttcacaa     6420

caatccaggt acagcaactg gtagtgcagt tggttgtgat ccagatatat tttggtcaaa     6480

aatccctatt ttgttagatg gagaaatctt tgcttttgac tacactggtt atgatgctag     6540

tttgtcacca gtgtggtttg cctgcttaaa gaaagttcta attaagttag gttacacaca     6600

tcaaacgtct tttatagatt atttgtgtca ttcagtacat ttatataagg acaaaaaata     6660

catagttaat ggtggaatgc cctctggttc ttcaggcacc agcatattca acactatgat     6720

caacaatata atcataagaa ctttattaat tagggtttac aaaggcatag acctggacca     6780

gttcaaaatg attgcctatg gggatgatgt tattgctagc tacccacata agattgatcc     6840

aggtttgctg gcagaagcag gtaaacagta tggattagta atgacgccag cagacaaagg     6900

aaccagtttt attgacacaa attgggaaaa tgtaactttc ttaaaaagat atttcagagc     6960

agatgatcaa tacccctttc tcatacatcc agtgatgcca atgaaagaga tacatgaatc     7020

tattagatgg actaaagatc ccagaaacac acaggatcat gttaggtctt tgtgctacct     7080

cgcatggcat aatggagagg aggcttataa tgaattttgc agaaaaatca gaagtgtgcc     7140

tgtgggaaga gcattgacac tacctgcata ctctagtctt agacggaaat ggttagattc     7200

gttctagaca actctaattg aaacccaagt tatagttact ttcatttaga ggtaaatttt     7260

ggtcacttgg gggccaaaaa aaaaaaaaaa aaaaaaaaaa gtcgac                    7306


<210>  9
<211>  7485
<212>  DNA
<213>  人工序列

<220>
<223>  EV-D68-miR133&206T的cDNA序列

<400>  9
taatacgact cactataggt taaaacagcc ttggggttgt tcccactcca agggcccacg       60

tggcggctag tactctggta cttcggtacc tttgtacgcc tgttttatct cccttcccaa      120

tgtaacttag aagttcttaa atcaatgctc aataggtggg gcgcaaacca gcgctctcat      180

gagcaagcac tcctgtctcc ccggtgaggt tgtataaact gttcccacgg ttgaaaacaa      240

cctatccgtt atccgctata gtacttcgag aaacctagta ccacctttgg attgttgacg      300

cgttgcgctc agcacactaa cccgtgtgta gcttgggtcg atgagtctgg acatacctca      360

ctggcgacag tggtccaggc tgcgttggcg gcctactcat ggtgaaagcc atgagacgct      420

agacatgaac aaggtgtgaa gagtctattg agctactata gagtcctccg gcccctgaat      480

gcggctaatc ctaaccatgg agcaagtgct cacaggccag tgagttgctt gtcgtaatgc      540

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttcacttttt acttttatga      600

ctgcttatgg tgacaatttg atattgttac catttagctt gtcaaatcaa ttgcaaaaga      660

tcctaaatct tatttatcaa cttgcatctt gataacttta atttgaaaat tttaacaatg      720

ggagctcagg ttactagaca acaaactggc actcatgaaa atgccaacat tgccacaaat      780

ggatctcata tcacatacaa tcagataaac ttttacaagg atagctatgc ggcttcagcc      840

agcaagcagg atttttcaca ggacccatca aaattcactg aaccagtagt ggaaggttta      900

aaagcagggg cgccagtttt gaaatctcct agtgctgagg catgtggcta cagtgataga      960

gtattacagc tcaaattagg aaattcagct attgtcaccc aggaagcagc gaactactgc     1020

tgcgcttatg gtgaatggcc caattactta ccagaccatg aagcagtagc cattgataaa     1080

cctacacaac cagaaactgc tacagataga ttctacactt tgaaatcagt caaatgggaa     1140

actggaagca caggatggtg gtggaaacta cccgatgcac tgaataatat aggcatgttt     1200

ggacagaatg tgcagcatca ctacctatat agatctggtt tcttgattca tgtgcagtgt     1260

aatgccacaa aattccatca aggtgcctta ttagtggtag caattccaga acatcagagg     1320

ggagcgcaca acaccaacac tagcccaggg tttgatgata taatgaaagg tgaagaagga     1380

gggaccttca atcatccata tgtccttgat gatggaacat cattggcttg tgcgacgata     1440

tttccacatc agtggataaa tctgagaacc aacaattcag caacaattgt tcttccctgg     1500

atgaatgctg ctccaatgga tttcccactt agacataatc agtggacgct agcaataata     1560

ccagtggtgc cattaggtac gcgtacaaca tcaagtatgg tcccaataac agtttcaatc     1620

gctccaatgt gttgtgagtt taatggactt agacacgcca ttactcaagg tgtcccaaca     1680

taccttttac caggctcggg acaattccta acaactgatg atcatagctc tgcaccagct     1740

ctcccgtgtt tcaacccaac tccagaaatg catatcccag ggcaggtccg taacatgcta     1800

gaagtggtcc aagtggaatc aatgatggag attaataaca cagaaagtgc agttggcatg     1860

gagcgtctta aggttgatat atcagcattg acagatgtcg atcaattgtt attcaacatt     1920

ccactggaca tacagttgga tgggccactt agaaacactt tggtaggaaa catatctaga     1980

tattacactc attggtctgg atccctagaa atgacgttta tgttttgtgg cagcttcatg     2040

gcaacgggaa aattaatcct gtgctatact cctccaggtg gatcatgccc gacaaccaga     2100

gagaccgcca tgttaggtac acatattgtt tgggattttg gattacaatc tagtgtaacc     2160

ctgataatac cttggattag tggatcccac tacaggatgt ttaataatga tgctaagtca     2220

actaatgcca acgttggcta tgtcacttgt tttatgcaga ccaatctgat agtccccagt     2280

gaatcctctg acacgtgttc cttgataggg ttcatagcag caaaagatga tttctccctc     2340

agattaatga gagacagccc tgacattgga caactagacc atttacatgc agcagaggca     2400

gcctaccaga tcgagagcat catcaaaaca gcgaccgaca ctgtgaaaag tgagattaat     2460

gctgaacttg gtgtggtccc tagcttaaat gcagttgaaa caggtgcaac ttctaacact     2520

gaaccagaag aagccataca aactcgcaca gtgataaatc agcacggtgt atccgagact     2580

ctagtggaga attttctcag tagagcagct ttggtatcaa agagaagttt tgaatacaaa     2640

gatcatactt cgtctgcagc acaagcagac aagaactttt tcaaatggac aattaacacc     2700

agatcctttg tacagttaag aagaaaatta gaattattca cataccttag atttgatgct     2760

gagatcacta tactcacaac tgtagcagtg aatggtagtg gtaataatac atacgtgggt     2820

cttcctgact tgacactcca agcaatgttt gtacccactg gtgctcttac cccagaaaaa     2880

caggactcat tccactggca gtcaggcagt aatgctagtg tattctttaa aatctccgac     2940

cccccagcca gaataaccat accttttatg tgcattaact cagcatactc agttttttat     3000

gatggctttg ccggatttga gaaaaacggt ctgtatggaa taaatccagc tgacactatt     3060

ggtaacttat gtgttagaat agtgaatgaa caccaaccag ttggtttcac agtgaccgtt     3120

agggtttaca tgaagcctaa acacataaaa gcatgggcac cacgaccacc acgaactttg     3180

ccatatatga gtattgcaaa tgcaaattac aaaggtaaag aaagagcacc aaatgcgctc     3240

aatgctataa ttggcaatag agacagtgtc aaaaccatgc ctcataatat agtgaacact     3300

ggtccaggct tcggaggagt ttttgtaggg tctttcaaaa taatcaacta tcacttggcc     3360

actacagaag agagacagtc agctatctat gtggattggc aatcagacgt cttggttacc     3420

cccattgctg ctcatggaag gcaccaaata gcaagatgca agtgcaacac aggggtttac     3480

tattgtaggc acaaaaacag aagttacccg atttgctttg aaggcccagg gattcaatgg     3540

attgaacaaa atgaatatta cccagcaagg taccagacca atgtactatt ggcagttggt     3600

cctgcggaag caggagattg cggtggttta ctagtttgtc cacatggggt aatcggtctt     3660

cttacagcag gagggggtgg aattgtagct ttcactgata tcaggaattt gctatggtta     3720

gatactgatg ctatggaaca aggcattact gattatattc aaaatcttgg taatgccttt     3780

ggagcaggat ttacagaaac aatctctaat aaagccaagg aagtgcaaga tatgctaatt     3840

ggagagagtt cactattaga aaaattgtta aaagctctaa tcaaaatcat atcagcatta     3900

gtaattgtaa tcagaaactc agaagattta gtcacagtca cagccacact agcattgttg     3960

ggatgccatg attcaccatg gagctacttg aaacagaagg tatgttcata cttaggtatt     4020

ccttatgtac ctagacaggg tgaatcgtgg cttaagaaat tcacagaggc atgcaatgct     4080

cttagaggtc tggattggct atcgcaaaag atagataaat tcatcaactg gcttaaaacc     4140

aaaatattac cagaagctag ggagaaatat gaatttgtgc aaaggctcaa acagttaccg     4200

gtgatagaaa accaagttag tacaatcgag catagctgcc caacaacaga acaacaacag     4260

gccttattca acaacgtcca atactattca cactactgta gaaagtacgc accactttac     4320

gcagtggaag caaagagggt agtagctctt gaaaagaaaa taaacaacta catccagttc     4380

aagtccaaat ctcgcattga accggtttgt ttaataatac atggctctcc aggaactggc     4440

aagtcagtgg cttcaaattt aattgccagg gctatcacag agaaattggg gggggacatt     4500

tattccttgc ctccagaccc taaatatttt gatggataca aacagcaaac agtggtcctc     4560

atggatgatt taatgcaaaa tccagatggg aatgacatat ctatgttctg ccaaatggtc     4620

tccactgtag atttcatacc cccaatggct agtttggagg aaaaaggaac tctatacacc     4680

agtccatttt taatagctac taccaatgct ggctcaatac atgcaccaac tgtatcagac     4740

tcaaaggctt tgtcacgcag atttaaattt gacgtggaca ttgaagtcac agattcatac     4800

aaggactcaa ataaattgga tatgtcaagg gcagtcgaga tgtgcaaacc agatggctgt     4860

gcccccacca attacaaaag atgctgccca ttgatctgtg gaaaggctat ccaattcaga     4920

gatcgcagaa ctaatgcaag atccactatt gatatgctag taactgatat tataaaggaa     4980

tatagaacca gaaacagtac acaggataag ctggaagctc tgtttcaggg gcctccacag     5040

tttaaagaga tcaaaatttc agtcacccca gatacaccag ctcctgatgc tataaatgac     5100

cttcttaggt cagtggattc tcaagaagtt agggattatt gccaaaagaa aggatggatt     5160

gtagtacacc catcaaatga gctaatagta gaaaaacaca ttagtagagc ttttattact     5220

ctacaagcca ttgccacctt tgtatcaata gctggtgtag tttatgttat atacaaactt     5280

tttgctggca ttcagggtcc atacacagga atccccaatc ctaaacctaa agtaccctct     5340

ctcagaacag ctaaagtgca aggaccaggg ttcgattttg cacaagccat aatgaagaaa     5400

aataccgtca ttgcaaggac tgaaaagggt gagttcacca tgctgggtgt atatgatagg     5460

gtagcggtca tccccacaca cgcatctgtt ggagaaacca tttacattaa tgatgtagag     5520

actaaagttt tagatgcgtg tgcacttaga gacttgactg atacaaactt agagataacc     5580

atagtcaaat tagaccgtaa tcaaaaattt agagatatca gacattttct gcccagatat     5640

gaggatgatt acaatgacgc tgtgcttagc gtacatacat caaaattccc aaatatgtat     5700

atcccagttg gacaagtcac caattatggc ttcttgaacc taggtggtac accgacgcac     5760

cgcattttaa tgtataactt cccaacaaga gctggccagt gtggtggtgt ggtgacaact     5820

acaggtaagg tgataggaat acatgtaggt ggaaatggag ctcaaggatt tgcagcaatg     5880

ctactacact cttacttttc cgatacacaa ggtgagatag ttagtagtga aaagagtggg     5940

gtgtgcatta acgcaccggc aaagactaaa ctccaaccta gtgttttcca tcaagttttt     6000

gaaggttcaa aggaaccagc agttctcaat ccaaaagatc ctaggcttaa aacagatttc     6060

gaggaggcca ttttctcaaa gtacacaggt aacaaaatta tgttaatgga tgagtacatg     6120

gaagaggcag tggatcatta tgtggggtgt ttagaaccat tagacatcag tgtggatccc     6180

atacccctgg aaagtgccat gtatggaatg gatggccttg aggcattaga cttaactacc     6240

agtgcaggat tcccttactt actacaaggg aagaagaaaa gggatatatt taatagacat     6300

actagagaca ccagtgaaat gacaaaaatg ttagagaaat atggagttga cctacctttt     6360

gtaacctttg taaaagatga gcttagatca agagaaaaag ttgaaaaagg gaaatcacgc     6420

ctgattgagg ccagttcctt gaatgactca gttgctatga gagttgcctt tggaaacctt     6480

tacgccacat ttcacaacaa tccaggtaca gcaactggta gtgcagttgg ttgtgatcca     6540

gatatatttt ggtcaaaaat ccctattttg ttagatggag aaatctttgc ttttgactac     6600

actggttatg atgctagttt gtcaccagtg tggtttgcct gcttaaagaa agttctaatt     6660

aagttaggtt acacacatca aacgtctttt atagattatt tgtgtcattc agtacattta     6720

tataaggaca aaaaatacat agttaatggt ggaatgccct ctggttcttc aggcaccagc     6780

atattcaaca ctatgatcaa caatataatc ataagaactt tattaattag ggtttacaaa     6840

ggcatagacc tggaccagtt caaaatgatt gcctatgggg atgatgttat tgctagctac     6900

ccacataaga ttgatccagg tttgctggca gaagcaggta aacagtatgg attagtaatg     6960

acgccagcag acaaaggaac cagttttatt gacacaaatt gggaaaatgt aactttctta     7020

aaaagatatt tcagagcaga tgatcaatac ccctttctca tacatccagt gatgccaatg     7080

aaagagatac atgaatctat tagatggact aaagatccca gaaacacaca ggatcatgtt     7140

aggtctttgt gctacctcgc atggcataat ggagaggagg cttataatga attttgcaga     7200

aaaatcagaa gtgtgcctgt gggaagagca ttgacactac ctgcatactc tagtcttaga     7260

cggaaatggt tagattcgtt ctagacaact ctaacagctg gttgaagggg accaacgata     7320

cagctggttg aaggggacca aaccggtcca cacacttcct tacattccat cacccacaca     7380

cttccttaca ttccaattga aacccaagtt atagttactt tcatttagag gtaaattttg     7440

gtcacttggg ggccaaaaaa aaaaaaaaaa aaaaaaaaag tcgac                     7485


<210>  10
<211>  7860
<212>  DNA
<213>  人工序列

<220>
<223>  EV-D68-GM-CSF的cDNA序列

<400>  10
taatacgact cactataggt taaaacagcc ttggggttgt tcccactcca agggcccacg       60

tggcggctag tactctggta cttcggtacc tttgtacgcc tgttttatct cccttcccaa      120

tgtaacttag aagttcttaa atcaatgctc aataggtggg gcgcaaacca gcgctctcat      180

gagcaagcac tcctgtctcc ccggtgaggt tgtataaact gttcccacgg ttgaaaacaa      240

cctatccgtt atccgctata gtacttcgag aaacctagta ccacctttgg attgttgacg      300

cgttgcgctc agcacactaa cccgtgtgta gcttgggtcg atgagtctgg acatacctca      360

ctggcgacag tggtccaggc tgcgttggcg gcctactcat ggtgaaagcc atgagacgct      420

agacatgaac aaggtgtgaa gagtctattg agctactata gagtcctccg gcccctgaat      480

gcggctaatc ctaaccatgg agcaagtgct cacaggccag tgagttgctt gtcgtaatgc      540

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttcacttttt acttttatga      600

ctgcttatgg tgacaatttg atattgttac catttagctt gtcaaatcaa ttgcaaaaga      660

tcctaaatct tatttatcaa cttgcatctt gataacttta atttgaaaat tttaacaatg      720

ggagctcagg ttactagaca acaaactggc actcatgaaa atgccaacat tgccacaaat      780

ggatctcata tcacatacaa tcagataaac ttttacaagg atagctatgc ggcttcagcc      840

agcaagcagg atttttcaca ggacccatca aaattcactg aaccagtagt ggaaggttta      900

aaagcagggg cgccagtttt gaaatctcct agtgctgagg catgtggcta cagtgataga      960

gtattacagc tcaaattagg aaattcagct attgtcaccc aggaagcagc gaactactgc     1020

tgcgcttatg gtgaatggcc caattactta ccagaccatg aagcagtagc cattgataaa     1080

cctacacaac cagaaactgc tacagataga ttctacactt tgaaatcagt caaatgggaa     1140

actggaagca caggatggtg gtggaaacta cccgatgcac tgaataatat aggcatgttt     1200

ggacagaatg tgcagcatca ctacctatat agatctggtt tcttgattca tgtgcagtgt     1260

aatgccacaa aattccatca aggtgcctta ttagtggtag caattccaga acatcagagg     1320

ggagcgcaca acaccaacac tagcccaggg tttgatgata taatgaaagg tgaagaagga     1380

gggaccttca atcatccata tgtccttgat gatggaacat cattggcttg tgcgacgata     1440

tttccacatc agtggataaa tctgagaacc aacaattcag caacaattgt tcttccctgg     1500

atgaatgctg ctccaatgga tttcccactt agacataatc agtggacgct agcaataata     1560

ccagtggtgc cattaggtac gcgtacaaca tcaagtatgg tcccaataac agtttcaatc     1620

gctccaatgt gttgtgagtt taatggactt agacacgcca ttactcaagg tgtcccaaca     1680

taccttttac caggctcggg acaattccta acaactgatg atcatagctc tgcaccagct     1740

ctcccgtgtt tcaacccaac tccagaaatg catatcccag ggcaggtccg taacatgcta     1800

gaagtggtcc aagtggaatc aatgatggag attaataaca cagaaagtgc agttggcatg     1860

gagcgtctta aggttgatat atcagcattg acagatgtcg atcaattgtt attcaacatt     1920

ccactggaca tacagttgga tgggccactt agaaacactt tggtaggaaa catatctaga     1980

tattacactc attggtctgg atccctagaa atgacgttta tgttttgtgg cagcttcatg     2040

gcaacgggaa aattaatcct gtgctatact cctccaggtg gatcatgccc gacaaccaga     2100

gagaccgcca tgttaggtac acatattgtt tgggattttg gattacaatc tagtgtaacc     2160

ctgataatac cttggattag tggatcccac tacaggatgt ttaataatga tgctaagtca     2220

actaatgcca acgttggcta tgtcacttgt tttatgcaga ccaatctgat agtccccagt     2280

gaatcctctg acacgtgttc cttgataggg ttcatagcag caaaagatga tttctccctc     2340

agattaatga gagacagccc tgacattgga caactagacc atttacatgc agcagaggca     2400

gcctaccaga tcgagagcat catcaaaaca gcgaccgaca ctgtgaaaag tgagattaat     2460

gctgaacttg gtgtggtccc tagcttaaat gcagttgaaa caggtgcaac ttctaacact     2520

gaaccagaag aagccataca aactcgcaca gtgataaatc agcacggtgt atccgagact     2580

ctagtggaga attttctcag tagagcagct ttggtatcaa agagaagttt tgaatacaaa     2640

gatcatactt cgtctgcagc acaagcagac aagaactttt tcaaatggac aattaacacc     2700

agatcctttg tacagttaag aagaaaatta gaattattca cataccttag atttgatgct     2760

gagatcacta tactcacaac tgtagcagtg aatggtagtg gtaataatac atacgtgggt     2820

cttcctgact tgacactcca agcaatgttt gtacccactg gtgctcttac cccagaaaaa     2880

caggactcat tccactggca gtcaggcagt aatgctagtg tattctttaa aatctccgac     2940

cccccagcca gaataaccat accttttatg tgcattaact cagcatactc agttttttat     3000

gatggctttg ccggatttga gaaaaacggt ctgtatggaa taaatccagc tgacactatt     3060

ggtaacttat gtgttagaat agtgaatgaa caccaaccag ttggtttcac agtgaccgtt     3120

agggtttaca tgaagcctaa acacataaaa gcatgggcac cacgaccacc acgaactttg     3180

ccatatatga gtattgcaaa tgcaaattac aaaggtaaag aaagagcacc aaatgcgctc     3240

aatgctataa ttggcaatag agacagtgtc aaaaccatgc ctcataatat agtgaacact     3300

ggtccaggct tctggctgca gagcctgctg ctcttgggca ctgtggcctg cagcatctct     3360

gcacccgccc gctcgcccag ccccagcacg cagccctggg agcatgtgaa tgccatccag     3420

gaggcccggc gtctcctgaa cctgagtaga gacactgctg ctgagatgaa tgaaacagta     3480

gaagtcatct cagaaatgtt tgacctccag gagccgacct gcctacagac ccgcctggag     3540

ctgtacaagc agggcctgcg gggcagcctc accaagctca agggcccctt gaccatgatg     3600

gccagccact acaagcagca ctgccctcca accccggaaa cttcctgtgc aacccagatt     3660

atcacctttg aaagtttcaa agagaacctg aaggactttc tgcttgtcat cccctttgac     3720

tgctgggagc cagtccagga gagtgtcaaa accatgcctc ataatatagt gaacactggt     3780

ccaggcttcg gaggagtttt tgtagggtct ttcaaaataa tcaactatca cttggccact     3840

acagaagaga gacagtcagc tatctatgtg gattggcaat cagacgtctt ggttaccccc     3900

attgctgctc atggaaggca ccaaatagca agatgcaagt gcaacacagg ggtttactat     3960

tgtaggcaca aaaacagaag ttacccgatt tgctttgaag gcccagggat tcaatggatt     4020

gaacaaaatg aatattaccc agcaaggtac cagaccaatg tactattggc agttggtcct     4080

gcggaagcag gagattgcgg tggtttacta gtttgtccac atggggtaat cggtcttctt     4140

acagcaggag ggggtggaat tgtagctttc actgatatca ggaatttgct atggttagat     4200

actgatgcta tggaacaagg cattactgat tatattcaaa atcttggtaa tgcctttgga     4260

gcaggattta cagaaacaat ctctaataaa gccaaggaag tgcaagatat gctaattgga     4320

gagagttcac tattagaaaa attgttaaaa gctctaatca aaatcatatc agcattagta     4380

attgtaatca gaaactcaga agatttagtc acagtcacag ccacactagc attgttggga     4440

tgccatgatt caccatggag ctacttgaaa cagaaggtat gttcatactt aggtattcct     4500

tatgtaccta gacagggtga atcgtggctt aagaaattca cagaggcatg caatgctctt     4560

agaggtctgg attggctatc gcaaaagata gataaattca tcaactggct taaaaccaaa     4620

atattaccag aagctaggga gaaatatgaa tttgtgcaaa ggctcaaaca gttaccggtg     4680

atagaaaacc aagttagtac aatcgagcat agctgcccaa caacagaaca acaacaggcc     4740

ttattcaaca acgtccaata ctattcacac tactgtagaa agtacgcacc actttacgca     4800

gtggaagcaa agagggtagt agctcttgaa aagaaaataa acaactacat ccagttcaag     4860

tccaaatctc gcattgaacc ggtttgttta ataatacatg gctctccagg aactggcaag     4920

tcagtggctt caaatttaat tgccagggct atcacagaga aattgggggg ggacatttat     4980

tccttgcctc cagaccctaa atattttgat ggatacaaac agcaaacagt ggtcctcatg     5040

gatgatttaa tgcaaaatcc agatgggaat gacatatcta tgttctgcca aatggtctcc     5100

actgtagatt tcataccccc aatggctagt ttggaggaaa aaggaactct atacaccagt     5160

ccatttttaa tagctactac caatgctggc tcaatacatg caccaactgt atcagactca     5220

aaggctttgt cacgcagatt taaatttgac gtggacattg aagtcacaga ttcatacaag     5280

gactcaaata aattggatat gtcaagggca gtcgagatgt gcaaaccaga tggctgtgcc     5340

cccaccaatt acaaaagatg ctgcccattg atctgtggaa aggctatcca attcagagat     5400

cgcagaacta atgcaagatc cactattgat atgctagtaa ctgatattat aaaggaatat     5460

agaaccagaa acagtacaca ggataagctg gaagctctgt ttcaggggcc tccacagttt     5520

aaagagatca aaatttcagt caccccagat acaccagctc ctgatgctat aaatgacctt     5580

cttaggtcag tggattctca agaagttagg gattattgcc aaaagaaagg atggattgta     5640

gtacacccat caaatgagct aatagtagaa aaacacatta gtagagcttt tattactcta     5700

caagccattg ccacctttgt atcaatagct ggtgtagttt atgttatata caaacttttt     5760

gctggcattc agggtccata cacaggaatc cccaatccta aacctaaagt accctctctc     5820

agaacagcta aagtgcaagg accagggttc gattttgcac aagccataat gaagaaaaat     5880

accgtcattg caaggactga aaagggtgag ttcaccatgc tgggtgtata tgatagggta     5940

gcggtcatcc ccacacacgc atctgttgga gaaaccattt acattaatga tgtagagact     6000

aaagttttag atgcgtgtgc acttagagac ttgactgata caaacttaga gataaccata     6060

gtcaaattag accgtaatca aaaatttaga gatatcagac attttctgcc cagatatgag     6120

gatgattaca atgacgctgt gcttagcgta catacatcaa aattcccaaa tatgtatatc     6180

ccagttggac aagtcaccaa ttatggcttc ttgaacctag gtggtacacc gacgcaccgc     6240

attttaatgt ataacttccc aacaagagct ggccagtgtg gtggtgtggt gacaactaca     6300

ggtaaggtga taggaataca tgtaggtgga aatggagctc aaggatttgc agcaatgcta     6360

ctacactctt acttttccga tacacaaggt gagatagtta gtagtgaaaa gagtggggtg     6420

tgcattaacg caccggcaaa gactaaactc caacctagtg ttttccatca agtttttgaa     6480

ggttcaaagg aaccagcagt tctcaatcca aaagatccta ggcttaaaac agatttcgag     6540

gaggccattt tctcaaagta cacaggtaac aaaattatgt taatggatga gtacatggaa     6600

gaggcagtgg atcattatgt ggggtgttta gaaccattag acatcagtgt ggatcccata     6660

cccctggaaa gtgccatgta tggaatggat ggccttgagg cattagactt aactaccagt     6720

gcaggattcc cttacttact acaagggaag aagaaaaggg atatatttaa tagacatact     6780

agagacacca gtgaaatgac aaaaatgtta gagaaatatg gagttgacct accttttgta     6840

acctttgtaa aagatgagct tagatcaaga gaaaaagttg aaaaagggaa atcacgcctg     6900

attgaggcca gttccttgaa tgactcagtt gctatgagag ttgcctttgg aaacctttac     6960

gccacatttc acaacaatcc aggtacagca actggtagtg cagttggttg tgatccagat     7020

atattttggt caaaaatccc tattttgtta gatggagaaa tctttgcttt tgactacact     7080

ggttatgatg ctagtttgtc accagtgtgg tttgcctgct taaagaaagt tctaattaag     7140

ttaggttaca cacatcaaac gtcttttata gattatttgt gtcattcagt acatttatat     7200

aaggacaaaa aatacatagt taatggtgga atgccctctg gttcttcagg caccagcata     7260

ttcaacacta tgatcaacaa tataatcata agaactttat taattagggt ttacaaaggc     7320

atagacctgg accagttcaa aatgattgcc tatggggatg atgttattgc tagctaccca     7380

cataagattg atccaggttt gctggcagaa gcaggtaaac agtatggatt agtaatgacg     7440

ccagcagaca aaggaaccag ttttattgac acaaattggg aaaatgtaac tttcttaaaa     7500

agatatttca gagcagatga tcaatacccc tttctcatac atccagtgat gccaatgaaa     7560

gagatacatg aatctattag atggactaaa gatcccagaa acacacagga tcatgttagg     7620

tctttgtgct acctcgcatg gcataatgga gaggaggctt ataatgaatt ttgcagaaaa     7680

atcagaagtg tgcctgtggg aagagcattg acactacctg catactctag tcttagacgg     7740

aaatggttag attcgttcta gacaactcta attgaaaccc aagttatagt tactttcatt     7800

tagaggtaaa ttttggtcac ttgggggcca aaaaaaaaaa aaaaaaaaaa aaaagtcgac     7860


<210>  11
<211>  8226
<212>  DNA
<213>  人工序列

<220>
<223>  EV-D68-Anti-PD1的cDNA序列

<400>  11
taatacgact cactataggt taaaacagcc ttggggttgt tcccactcca agggcccacg       60

tggcggctag tactctggta cttcggtacc tttgtacgcc tgttttatct cccttcccaa      120

tgtaacttag aagttcttaa atcaatgctc aataggtggg gcgcaaacca gcgctctcat      180

gagcaagcac tcctgtctcc ccggtgaggt tgtataaact gttcccacgg ttgaaaacaa      240

cctatccgtt atccgctata gtacttcgag aaacctagta ccacctttgg attgttgacg      300

cgttgcgctc agcacactaa cccgtgtgta gcttgggtcg atgagtctgg acatacctca      360

ctggcgacag tggtccaggc tgcgttggcg gcctactcat ggtgaaagcc atgagacgct      420

agacatgaac aaggtgtgaa gagtctattg agctactata gagtcctccg gcccctgaat      480

gcggctaatc ctaaccatgg agcaagtgct cacaggccag tgagttgctt gtcgtaatgc      540

gcaagtccgt ggcggaaccg actactttgg gtgtccgtgt ttcacttttt acttttatga      600

ctgcttatgg tgacaatttg atattgttac catttagctt gtcaaatcaa ttgcaaaaga      660

tcctaaatct tatttatcaa cttgcatctt gataacttta atttgaaaat tttaacaatg      720

ggagctcagg ttactagaca acaaactggc actcatgaaa atgccaacat tgccacaaat      780

ggatctcata tcacatacaa tcagataaac ttttacaagg atagctatgc ggcttcagcc      840

agcaagcagg atttttcaca ggacccatca aaattcactg aaccagtagt ggaaggttta      900

aaagcagggg cgccagtttt gaaatctcct agtgctgagg catgtggcta cagtgataga      960

gtattacagc tcaaattagg aaattcagct attgtcaccc aggaagcagc gaactactgc     1020

tgcgcttatg gtgaatggcc caattactta ccagaccatg aagcagtagc cattgataaa     1080

cctacacaac cagaaactgc tacagataga ttctacactt tgaaatcagt caaatgggaa     1140

actggaagca caggatggtg gtggaaacta cccgatgcac tgaataatat aggcatgttt     1200

ggacagaatg tgcagcatca ctacctatat agatctggtt tcttgattca tgtgcagtgt     1260

aatgccacaa aattccatca aggtgcctta ttagtggtag caattccaga acatcagagg     1320

ggagcgcaca acaccaacac tagcccaggg tttgatgata taatgaaagg tgaagaagga     1380

gggaccttca atcatccata tgtccttgat gatggaacat cattggcttg tgcgacgata     1440

tttccacatc agtggataaa tctgagaacc aacaattcag caacaattgt tcttccctgg     1500

atgaatgctg ctccaatgga tttcccactt agacataatc agtggacgct agcaataata     1560

ccagtggtgc cattaggtac gcgtacaaca tcaagtatgg tcccaataac agtttcaatc     1620

gctccaatgt gttgtgagtt taatggactt agacacgcca ttactcaagg tgtcccaaca     1680

taccttttac caggctcggg acaattccta acaactgatg atcatagctc tgcaccagct     1740

ctcccgtgtt tcaacccaac tccagaaatg catatcccag ggcaggtccg taacatgcta     1800

gaagtggtcc aagtggaatc aatgatggag attaataaca cagaaagtgc agttggcatg     1860

gagcgtctta aggttgatat atcagcattg acagatgtcg atcaattgtt attcaacatt     1920

ccactggaca tacagttgga tgggccactt agaaacactt tggtaggaaa catatctaga     1980

tattacactc attggtctgg atccctagaa atgacgttta tgttttgtgg cagcttcatg     2040

gcaacgggaa aattaatcct gtgctatact cctccaggtg gatcatgccc gacaaccaga     2100

gagaccgcca tgttaggtac acatattgtt tgggattttg gattacaatc tagtgtaacc     2160

ctgataatac cttggattag tggatcccac tacaggatgt ttaataatga tgctaagtca     2220

actaatgcca acgttggcta tgtcacttgt tttatgcaga ccaatctgat agtccccagt     2280

gaatcctctg acacgtgttc cttgataggg ttcatagcag caaaagatga tttctccctc     2340

agattaatga gagacagccc tgacattgga caactagacc atttacatgc agcagaggca     2400

gcctaccaga tcgagagcat catcaaaaca gcgaccgaca ctgtgaaaag tgagattaat     2460

gctgaacttg gtgtggtccc tagcttaaat gcagttgaaa caggtgcaac ttctaacact     2520

gaaccagaag aagccataca aactcgcaca gtgataaatc agcacggtgt atccgagact     2580

ctagtggaga attttctcag tagagcagct ttggtatcaa agagaagttt tgaatacaaa     2640

gatcatactt cgtctgcagc acaagcagac aagaactttt tcaaatggac aattaacacc     2700

agatcctttg tacagttaag aagaaaatta gaattattca cataccttag atttgatgct     2760

gagatcacta tactcacaac tgtagcagtg aatggtagtg gtaataatac atacgtgggt     2820

cttcctgact tgacactcca agcaatgttt gtacccactg gtgctcttac cccagaaaaa     2880

caggactcat tccactggca gtcaggcagt aatgctagtg tattctttaa aatctccgac     2940

cccccagcca gaataaccat accttttatg tgcattaact cagcatactc agttttttat     3000

gatggctttg ccggatttga gaaaaacggt ctgtatggaa taaatccagc tgacactatt     3060

ggtaacttat gtgttagaat agtgaatgaa caccaaccag ttggtttcac agtgaccgtt     3120

agggtttaca tgaagcctaa acacataaaa gcatgggcac cacgaccacc acgaactttg     3180

ccatatatga gtattgcaaa tgcaaattac aaaggtaaag aaagagcacc aaatgcgctc     3240

aatgctataa ttggcaatag agacagtgtc aaaaccatgc ctcataatat agtgaacact     3300

ggtccaggct tcatgaagca cctgtggttc ttcctgctgc tggtggccgc tcctaggtgg     3360

gtgctgtccc aggtgcagct ggtgcagagc ggcgtggagg tgaagaagcc cggcgcttcc     3420

gtgaaggtgt cctgcaaggc ctccggctac accttcacca actactacat gtactgggtg     3480

aggcaggccc ctggacaggg actggagtgg atgggcggca tcaacccttc caacggcggc     3540

accaacttca acgagaagtt caagaaccgg gtgaccctga ccaccgactc ctccaccacc     3600

accgcctaca tggagctgaa gtccctgcag tttgacgaca ccgccgtgta ctactgcgcc     3660

aggagggact accggttcga catgggcttc gactactggg gccagggcac aaccgtgacc     3720

gtgtccagcg gaggtggcgg atctggaggg ggtggtagcg gtggaggcgg gagtgagatc     3780

gtgctgaccc agtcccctgc tacactgtcc ctgtcccccg gcgagagggc tacactgagc     3840

tgcagggcct ccaagggcgt gtccacctcc ggctactcct acctgcactg gtaccagcag     3900

aagcctggac aggctcccag gctgctgatc tacctggcct cctacctgga gtccggcgtg     3960

cctgctaggt tttccggcag cggcagcggc accgatttca ccctgaccat ctcctccctg     4020

gagcccgagg acttcgccgt gtactactgc cagcactcca gggatctgcc tctgaccttc     4080

ggcggcggca ccaaggtgga gatcaagagt gtcaaaacca tgcctcataa tatagtgaac     4140

actggtccag gcttcggagg agtttttgta gggtctttca aaataatcaa ctatcacttg     4200

gccactacag aagagagaca gtcagctatc tatgtggatt ggcaatcaga cgtcttggtt     4260

acccccattg ctgctcatgg aaggcaccaa atagcaagat gcaagtgcaa cacaggggtt     4320

tactattgta ggcacaaaaa cagaagttac ccgatttgct ttgaaggccc agggattcaa     4380

tggattgaac aaaatgaata ttacccagca aggtaccaga ccaatgtact attggcagtt     4440

ggtcctgcgg aagcaggaga ttgcggtggt ttactagttt gtccacatgg ggtaatcggt     4500

cttcttacag caggaggggg tggaattgta gctttcactg atatcaggaa tttgctatgg     4560

ttagatactg atgctatgga acaaggcatt actgattata ttcaaaatct tggtaatgcc     4620

tttggagcag gatttacaga aacaatctct aataaagcca aggaagtgca agatatgcta     4680

attggagaga gttcactatt agaaaaattg ttaaaagctc taatcaaaat catatcagca     4740

ttagtaattg taatcagaaa ctcagaagat ttagtcacag tcacagccac actagcattg     4800

ttgggatgcc atgattcacc atggagctac ttgaaacaga aggtatgttc atacttaggt     4860

attccttatg tacctagaca gggtgaatcg tggcttaaga aattcacaga ggcatgcaat     4920

gctcttagag gtctggattg gctatcgcaa aagatagata aattcatcaa ctggcttaaa     4980

accaaaatat taccagaagc tagggagaaa tatgaatttg tgcaaaggct caaacagtta     5040

ccggtgatag aaaaccaagt tagtacaatc gagcatagct gcccaacaac agaacaacaa     5100

caggccttat tcaacaacgt ccaatactat tcacactact gtagaaagta cgcaccactt     5160

tacgcagtgg aagcaaagag ggtagtagct cttgaaaaga aaataaacaa ctacatccag     5220

ttcaagtcca aatctcgcat tgaaccggtt tgtttaataa tacatggctc tccaggaact     5280

ggcaagtcag tggcttcaaa tttaattgcc agggctatca cagagaaatt ggggggggac     5340

atttattcct tgcctccaga ccctaaatat tttgatggat acaaacagca aacagtggtc     5400

ctcatggatg atttaatgca aaatccagat gggaatgaca tatctatgtt ctgccaaatg     5460

gtctccactg tagatttcat acccccaatg gctagtttgg aggaaaaagg aactctatac     5520

accagtccat ttttaatagc tactaccaat gctggctcaa tacatgcacc aactgtatca     5580

gactcaaagg ctttgtcacg cagatttaaa tttgacgtgg acattgaagt cacagattca     5640

tacaaggact caaataaatt ggatatgtca agggcagtcg agatgtgcaa accagatggc     5700

tgtgccccca ccaattacaa aagatgctgc ccattgatct gtggaaaggc tatccaattc     5760

agagatcgca gaactaatgc aagatccact attgatatgc tagtaactga tattataaag     5820

gaatatagaa ccagaaacag tacacaggat aagctggaag ctctgtttca ggggcctcca     5880

cagtttaaag agatcaaaat ttcagtcacc ccagatacac cagctcctga tgctataaat     5940

gaccttctta ggtcagtgga ttctcaagaa gttagggatt attgccaaaa gaaaggatgg     6000

attgtagtac acccatcaaa tgagctaata gtagaaaaac acattagtag agcttttatt     6060

actctacaag ccattgccac ctttgtatca atagctggtg tagtttatgt tatatacaaa     6120

ctttttgctg gcattcaggg tccatacaca ggaatcccca atcctaaacc taaagtaccc     6180

tctctcagaa cagctaaagt gcaaggacca gggttcgatt ttgcacaagc cataatgaag     6240

aaaaataccg tcattgcaag gactgaaaag ggtgagttca ccatgctggg tgtatatgat     6300

agggtagcgg tcatccccac acacgcatct gttggagaaa ccatttacat taatgatgta     6360

gagactaaag ttttagatgc gtgtgcactt agagacttga ctgatacaaa cttagagata     6420

accatagtca aattagaccg taatcaaaaa tttagagata tcagacattt tctgcccaga     6480

tatgaggatg attacaatga cgctgtgctt agcgtacata catcaaaatt cccaaatatg     6540

tatatcccag ttggacaagt caccaattat ggcttcttga acctaggtgg tacaccgacg     6600

caccgcattt taatgtataa cttcccaaca agagctggcc agtgtggtgg tgtggtgaca     6660

actacaggta aggtgatagg aatacatgta ggtggaaatg gagctcaagg atttgcagca     6720

atgctactac actcttactt ttccgataca caaggtgaga tagttagtag tgaaaagagt     6780

ggggtgtgca ttaacgcacc ggcaaagact aaactccaac ctagtgtttt ccatcaagtt     6840

tttgaaggtt caaaggaacc agcagttctc aatccaaaag atcctaggct taaaacagat     6900

ttcgaggagg ccattttctc aaagtacaca ggtaacaaaa ttatgttaat ggatgagtac     6960

atggaagagg cagtggatca ttatgtgggg tgtttagaac cattagacat cagtgtggat     7020

cccatacccc tggaaagtgc catgtatgga atggatggcc ttgaggcatt agacttaact     7080

accagtgcag gattccctta cttactacaa gggaagaaga aaagggatat atttaataga     7140

catactagag acaccagtga aatgacaaaa atgttagaga aatatggagt tgacctacct     7200

tttgtaacct ttgtaaaaga tgagcttaga tcaagagaaa aagttgaaaa agggaaatca     7260

cgcctgattg aggccagttc cttgaatgac tcagttgcta tgagagttgc ctttggaaac     7320

ctttacgcca catttcacaa caatccaggt acagcaactg gtagtgcagt tggttgtgat     7380

ccagatatat tttggtcaaa aatccctatt ttgttagatg gagaaatctt tgcttttgac     7440

tacactggtt atgatgctag tttgtcacca gtgtggtttg cctgcttaaa gaaagttcta     7500

attaagttag gttacacaca tcaaacgtct tttatagatt atttgtgtca ttcagtacat     7560

ttatataagg acaaaaaata catagttaat ggtggaatgc cctctggttc ttcaggcacc     7620

agcatattca acactatgat caacaatata atcataagaa ctttattaat tagggtttac     7680

aaaggcatag acctggacca gttcaaaatg attgcctatg gggatgatgt tattgctagc     7740

tacccacata agattgatcc aggtttgctg gcagaagcag gtaaacagta tggattagta     7800

atgacgccag cagacaaagg aaccagtttt attgacacaa attgggaaaa tgtaactttc     7860

ttaaaaagat atttcagagc agatgatcaa tacccctttc tcatacatcc agtgatgcca     7920

atgaaagaga tacatgaatc tattagatgg actaaagatc ccagaaacac acaggatcat     7980

gttaggtctt tgtgctacct cgcatggcat aatggagagg aggcttataa tgaattttgc     8040

agaaaaatca gaagtgtgcc tgtgggaaga gcattgacac tacctgcata ctctagtctt     8100

agacggaaat ggttagattc gttctagaca actctaattg aaacccaagt tatagttact     8160

ttcatttaga ggtaaatttt ggtcacttgg gggccaaaaa aaaaaaaaaa aaaaaaaaaa     8220

gtcgac                                                                8226


<210>  12
<211>  7383
<212>  RNA
<213>  人工序列

<220>
<223>  EV-D68-WT的基因组序列

<400>  12
uaauacgacu cacuauaggu uaaaacagcc uugggguugu ucccacucca agggcccacg       60

uggcggcuag uacucuggua cuucgguacc uuuguacgcc uguuuuaucu cccuucccaa      120

uguaacuuag aaguucuuaa aucaaugcuc aauagguggg gcgcaaacca gcgcucucau      180

gagcaagcac uccugucucc ccggugaggu uguauaaacu guucccacgg uugaaaacaa      240

ccuauccguu auccgcuaua guacuucgag aaaccuagua ccaccuuugg auuguugacg      300

cguugcgcuc agcacacuaa cccgugugua gcuugggucg augagucugg acauaccuca      360

cuggcgacag ugguccaggc ugcguuggcg gccuacucau ggugaaagcc augagacgcu      420

agacaugaac aaggugugaa gagucuauug agcuacuaua gaguccuccg gccccugaau      480

gcggcuaauc cuaaccaugg agcaagugcu cacaggccag ugaguugcuu gucguaaugc      540

gcaaguccgu ggcggaaccg acuacuuugg guguccgugu uucacuuuuu acuuuuauga      600

cugcuuaugg ugacaauuug auauuguuac cauuuagcuu gucaaaucaa uugcaaaaga      660

uccuaaaucu uauuuaucaa cuugcaucuu gauaacuuua auuugaaaau uuuaacaaug      720

ggagcucagg uuacuagaca acaaacuggc acucaugaaa augccaacau ugccacaaau      780

ggaucucaua ucacauacaa ucagauaaac uuuuacaagg auagcuaugc ggcuucagcc      840

agcaagcagg auuuuucaca ggacccauca aaauucacug aaccaguagu ggaagguuua      900

aaagcagggg cgccaguuuu gaaaucuccu agugcugagg cauguggcua cagugauaga      960

guauuacagc ucaaauuagg aaauucagcu auugucaccc aggaagcagc gaacuacugc     1020

ugcgcuuaug gugaauggcc caauuacuua ccagaccaug aagcaguagc cauugauaaa     1080

ccuacacaac cagaaacugc uacagauaga uucuacacuu ugaaaucagu caaaugggaa     1140

acuggaagca caggauggug guggaaacua cccgaugcac ugaauaauau aggcauguuu     1200

ggacagaaug ugcagcauca cuaccuauau agaucugguu ucuugauuca ugugcagugu     1260

aaugccacaa aauuccauca aggugccuua uuagugguag caauuccaga acaucagagg     1320

ggagcgcaca acaccaacac uagcccaggg uuugaugaua uaaugaaagg ugaagaagga     1380

gggaccuuca aucauccaua uguccuugau gauggaacau cauuggcuug ugcgacgaua     1440

uuuccacauc aguggauaaa ucugagaacc aacaauucag caacaauugu ucuucccugg     1500

augaaugcug cuccaaugga uuucccacuu agacauaauc aguggacgcu agcaauaaua     1560

ccaguggugc cauuagguac gcguacaaca ucaaguaugg ucccaauaac aguuucaauc     1620

gcuccaaugu guugugaguu uaauggacuu agacacgcca uuacucaagg ugucccaaca     1680

uaccuuuuac caggcucggg acaauuccua acaacugaug aucauagcuc ugcaccagcu     1740

cucccguguu ucaacccaac uccagaaaug cauaucccag ggcagguccg uaacaugcua     1800

gaaguggucc aaguggaauc aaugauggag auuaauaaca cagaaagugc aguuggcaug     1860

gagcgucuua agguugauau aucagcauug acagaugucg aucaauuguu auucaacauu     1920

ccacuggaca uacaguugga ugggccacuu agaaacacuu ugguaggaaa cauaucuaga     1980

uauuacacuc auuggucugg aucccuagaa augacguuua uguuuugugg cagcuucaug     2040

gcaacgggaa aauuaauccu gugcuauacu ccuccaggug gaucaugccc gacaaccaga     2100

gagaccgcca uguuagguac acauauuguu ugggauuuug gauuacaauc uaguguaacc     2160

cugauaauac cuuggauuag uggaucccac uacaggaugu uuaauaauga ugcuaaguca     2220

acuaaugcca acguuggcua ugucacuugu uuuaugcaga ccaaucugau aguccccagu     2280

gaauccucug acacguguuc cuugauaggg uucauagcag caaaagauga uuucucccuc     2340

agauuaauga gagacagccc ugacauugga caacuagacc auuuacaugc agcagaggca     2400

gccuaccaga ucgagagcau caucaaaaca gcgaccgaca cugugaaaag ugagauuaau     2460

gcugaacuug gugugguccc uagcuuaaau gcaguugaaa caggugcaac uucuaacacu     2520

gaaccagaag aagccauaca aacucgcaca gugauaaauc agcacggugu auccgagacu     2580

cuaguggaga auuuucucag uagagcagcu uugguaucaa agagaaguuu ugaauacaaa     2640

gaucauacuu cgucugcagc acaagcagac aagaacuuuu ucaaauggac aauuaacacc     2700

agauccuuug uacaguuaag aagaaaauua gaauuauuca cauaccuuag auuugaugcu     2760

gagaucacua uacucacaac uguagcagug aaugguagug guaauaauac auacgugggu     2820

cuuccugacu ugacacucca agcaauguuu guacccacug gugcucuuac cccagaaaaa     2880

caggacucau uccacuggca gucaggcagu aaugcuagug uauucuuuaa aaucuccgac     2940

cccccagcca gaauaaccau accuuuuaug ugcauuaacu cagcauacuc aguuuuuuau     3000

gauggcuuug ccggauuuga gaaaaacggu cuguauggaa uaaauccagc ugacacuauu     3060

gguaacuuau guguuagaau agugaaugaa caccaaccag uugguuucac agugaccguu     3120

aggguuuaca ugaagccuaa acacauaaaa gcaugggcac cacgaccacc acgaacuuug     3180

ccauauauga guauugcaaa ugcaaauuac aaagguaaag aaagagcacc aaaugcgcuc     3240

aaugcuauaa uuggcaauag agacaguguc aaaaccaugc cucauaauau agugaacacu     3300

gguccaggcu ucggaggagu uuuuguaggg ucuuucaaaa uaaucaacua ucacuuggcc     3360

acuacagaag agagacaguc agcuaucuau guggauuggc aaucagacgu cuugguuacc     3420

cccauugcug cucauggaag gcaccaaaua gcaagaugca agugcaacac agggguuuac     3480

uauuguaggc acaaaaacag aaguuacccg auuugcuuug aaggcccagg gauucaaugg     3540

auugaacaaa augaauauua cccagcaagg uaccagacca auguacuauu ggcaguuggu     3600

ccugcggaag caggagauug cggugguuua cuaguuuguc cacauggggu aaucggucuu     3660

cuuacagcag gagggggugg aauuguagcu uucacugaua ucaggaauuu gcuaugguua     3720

gauacugaug cuauggaaca aggcauuacu gauuauauuc aaaaucuugg uaaugccuuu     3780

ggagcaggau uuacagaaac aaucucuaau aaagccaagg aagugcaaga uaugcuaauu     3840

ggagagaguu cacuauuaga aaaauuguua aaagcucuaa ucaaaaucau aucagcauua     3900

guaauuguaa ucagaaacuc agaagauuua gucacaguca cagccacacu agcauuguug     3960

ggaugccaug auucaccaug gagcuacuug aaacagaagg uauguucaua cuuagguauu     4020

ccuuauguac cuagacaggg ugaaucgugg cuuaagaaau ucacagaggc augcaaugcu     4080

cuuagagguc uggauuggcu aucgcaaaag auagauaaau ucaucaacug gcuuaaaacc     4140

aaaauauuac cagaagcuag ggagaaauau gaauuugugc aaaggcucaa acaguuaccg     4200

gugauagaaa accaaguuag uacaaucgag cauagcugcc caacaacaga acaacaacag     4260

gccuuauuca acaacgucca auacuauuca cacuacugua gaaaguacgc accacuuuac     4320

gcaguggaag caaagagggu aguagcucuu gaaaagaaaa uaaacaacua cauccaguuc     4380

aaguccaaau cucgcauuga accgguuugu uuaauaauac auggcucucc aggaacuggc     4440

aagucagugg cuucaaauuu aauugccagg gcuaucacag agaaauuggg gggggacauu     4500

uauuccuugc cuccagaccc uaaauauuuu gauggauaca aacagcaaac agugguccuc     4560

auggaugauu uaaugcaaaa uccagauggg aaugacauau cuauguucug ccaaaugguc     4620

uccacuguag auuucauacc cccaauggcu aguuuggagg aaaaaggaac ucuauacacc     4680

aguccauuuu uaauagcuac uaccaaugcu ggcucaauac augcaccaac uguaucagac     4740

ucaaaggcuu ugucacgcag auuuaaauuu gacguggaca uugaagucac agauucauac     4800

aaggacucaa auaaauugga uaugucaagg gcagucgaga ugugcaaacc agauggcugu     4860

gcccccacca auuacaaaag augcugccca uugaucugug gaaaggcuau ccaauucaga     4920

gaucgcagaa cuaaugcaag auccacuauu gauaugcuag uaacugauau uauaaaggaa     4980

uauagaacca gaaacaguac acaggauaag cuggaagcuc uguuucaggg gccuccacag     5040

uuuaaagaga ucaaaauuuc agucacccca gauacaccag cuccugaugc uauaaaugac     5100

cuucuuaggu caguggauuc ucaagaaguu agggauuauu gccaaaagaa aggauggauu     5160

guaguacacc caucaaauga gcuaauagua gaaaaacaca uuaguagagc uuuuauuacu     5220

cuacaagcca uugccaccuu uguaucaaua gcugguguag uuuauguuau auacaaacuu     5280

uuugcuggca uucagggucc auacacagga auccccaauc cuaaaccuaa aguacccucu     5340

cucagaacag cuaaagugca aggaccaggg uucgauuuug cacaagccau aaugaagaaa     5400

aauaccguca uugcaaggac ugaaaagggu gaguucacca ugcugggugu auaugauagg     5460

guagcgguca uccccacaca cgcaucuguu ggagaaacca uuuacauuaa ugauguagag     5520

acuaaaguuu uagaugcgug ugcacuuaga gacuugacug auacaaacuu agagauaacc     5580

auagucaaau uagaccguaa ucaaaaauuu agagauauca gacauuuucu gcccagauau     5640

gaggaugauu acaaugacgc ugugcuuagc guacauacau caaaauuccc aaauauguau     5700

aucccaguug gacaagucac caauuauggc uucuugaacc uaggugguac accgacgcac     5760

cgcauuuuaa uguauaacuu cccaacaaga gcuggccagu gugguggugu ggugacaacu     5820

acagguaagg ugauaggaau acauguaggu ggaaauggag cucaaggauu ugcagcaaug     5880

cuacuacacu cuuacuuuuc cgauacacaa ggugagauag uuaguaguga aaagaguggg     5940

gugugcauua acgcaccggc aaagacuaaa cuccaaccua guguuuucca ucaaguuuuu     6000

gaagguucaa aggaaccagc aguucucaau ccaaaagauc cuaggcuuaa aacagauuuc     6060

gaggaggcca uuuucucaaa guacacaggu aacaaaauua uguuaaugga ugaguacaug     6120

gaagaggcag uggaucauua uguggggugu uuagaaccau uagacaucag uguggauccc     6180

auaccccugg aaagugccau guauggaaug gauggccuug aggcauuaga cuuaacuacc     6240

agugcaggau ucccuuacuu acuacaaggg aagaagaaaa gggauauauu uaauagacau     6300

acuagagaca ccagugaaau gacaaaaaug uuagagaaau auggaguuga ccuaccuuuu     6360

guaaccuuug uaaaagauga gcuuagauca agagaaaaag uugaaaaagg gaaaucacgc     6420

cugauugagg ccaguuccuu gaaugacuca guugcuauga gaguugccuu uggaaaccuu     6480

uacgccacau uucacaacaa uccagguaca gcaacuggua gugcaguugg uugugaucca     6540

gauauauuuu ggucaaaaau cccuauuuug uuagauggag aaaucuuugc uuuugacuac     6600

acugguuaug augcuaguuu gucaccagug ugguuugccu gcuuaaagaa aguucuaauu     6660

aaguuagguu acacacauca aacgucuuuu auagauuauu ugugucauuc aguacauuua     6720

uauaaggaca aaaaauacau aguuaauggu ggaaugcccu cugguucuuc aggcaccagc     6780

auauucaaca cuaugaucaa caauauaauc auaagaacuu uauuaauuag gguuuacaaa     6840

ggcauagacc uggaccaguu caaaaugauu gccuaugggg augauguuau ugcuagcuac     6900

ccacauaaga uugauccagg uuugcuggca gaagcaggua aacaguaugg auuaguaaug     6960

acgccagcag acaaaggaac caguuuuauu gacacaaauu gggaaaaugu aacuuucuua     7020

aaaagauauu ucagagcaga ugaucaauac cccuuucuca uacauccagu gaugccaaug     7080

aaagagauac augaaucuau uagauggacu aaagauccca gaaacacaca ggaucauguu     7140

aggucuuugu gcuaccucgc auggcauaau ggagaggagg cuuauaauga auuuugcaga     7200

aaaaucagaa gugugccugu gggaagagca uugacacuac cugcauacuc uagucuuaga     7260

cggaaauggu uagauucguu cuagacaacu cuaauugaaa cccaaguuau aguuacuuuc     7320

auuuagaggu aaauuuuggu cacuuggggg ccaaaaaaaa aaaaaaaaaa aaaaaaaguc     7380

gac                                                                   7383


<210>  13
<211>  7306
<212>  RNA
<213>  人工序列

<220>
<223>  EV-D68-HRV2的基因组序列

<400>  13
uaauacgacu cacuauaggu uaaaacagcc uugggguugu ucccacucca agggcccacg       60

uggcggcuag uacucuggua cuucgguacc uuuguacgcc uguuuuaucu cccuucccaa      120

uguaacuuag aagaacuuag aaguuuuuca caaagaccaa uagccgguaa ucagccagau      180

uacugaaggu caagcacuuc uguuuccccg gucaauguug auaugcucca acagggcaaa      240

aacaacugcg aucguuaacc gcaaagcgcc uacgcaaagc uuaguagcau cuuugaaauc      300

guuuggcugg ucgauccgcc auuuccccug guagaccugg cagaugaggc uagaaauacc      360

ccacuggcga caguguucua gccugcgugg cugccugcac acccuauggg ugugaagcca      420

aacaauggac aaggugugaa gagccccgug ugcucgcuuu gaguccuccg gccccugaau      480

guggcuaacc uuaacccugc agcuagagca cguaacccaa uguguaucua gucguaauga      540

gcaauugcgg gaugggacca acuacuuugg guguccgugu uucacuuuuu ccuuuauauu      600

ugcuuauggu gacaauauau acaauauaua uauuggcacc augggagcuc agguuacuag      660

acaacaaacu ggcacucaug aaaaugccaa cauugccaca aauggaucuc auaucacaua      720

caaucagaua aacuuuuaca aggauagcua ugcggcuuca gccagcaagc aggauuuuuc      780

acaggaccca ucaaaauuca cugaaccagu aguggaaggu uuaaaagcag gggcgccagu      840

uuugaaaucu ccuagugcug aggcaugugg cuacagugau agaguauuac agcucaaauu      900

aggaaauuca gcuauuguca cccaggaagc agcgaacuac ugcugcgcuu auggugaaug      960

gcccaauuac uuaccagacc augaagcagu agccauugau aaaccuacac aaccagaaac     1020

ugcuacagau agauucuaca cuuugaaauc agucaaaugg gaaacuggaa gcacaggaug     1080

gugguggaaa cuacccgaug cacugaauaa uauaggcaug uuuggacaga augugcagca     1140

ucacuaccua uauagaucug guuucuugau ucaugugcag uguaaugcca caaaauucca     1200

ucaaggugcc uuauuagugg uagcaauucc agaacaucag aggggagcgc acaacaccaa     1260

cacuagccca ggguuugaug auauaaugaa aggugaagaa ggagggaccu ucaaucaucc     1320

auauguccuu gaugauggaa caucauuggc uugugcgacg auauuuccac aucaguggau     1380

aaaucugaga accaacaauu cagcaacaau uguucuuccc uggaugaaug cugcuccaau     1440

ggauuuccca cuuagacaua aucaguggac gcuagcaaua auaccagugg ugccauuagg     1500

uacgcguaca acaucaagua uggucccaau aacaguuuca aucgcuccaa uguguuguga     1560

guuuaaugga cuuagacacg ccauuacuca agguguccca acauaccuuu uaccaggcuc     1620

gggacaauuc cuaacaacug augaucauag cucugcacca gcucucccgu guuucaaccc     1680

aacuccagaa augcauaucc cagggcaggu ccguaacaug cuagaagugg uccaagugga     1740

aucaaugaug gagauuaaua acacagaaag ugcaguuggc auggagcguc uuaagguuga     1800

uauaucagca uugacagaug ucgaucaauu guuauucaac auuccacugg acauacaguu     1860

ggaugggcca cuuagaaaca cuuugguagg aaacauaucu agauauuaca cucauugguc     1920

uggaucccua gaaaugacgu uuauguuuug uggcagcuuc auggcaacgg gaaaauuaau     1980

ccugugcuau acuccuccag guggaucaug cccgacaacc agagagaccg ccauguuagg     2040

uacacauauu guuugggauu uuggauuaca aucuagugua acccugauaa uaccuuggau     2100

uaguggaucc cacuacagga uguuuaauaa ugaugcuaag ucaacuaaug ccaacguugg     2160

cuaugucacu uguuuuaugc agaccaaucu gauagucccc agugaauccu cugacacgug     2220

uuccuugaua ggguucauag cagcaaaaga ugauuucucc cucagauuaa ugagagacag     2280

cccugacauu ggacaacuag accauuuaca ugcagcagag gcagccuacc agaucgagag     2340

caucaucaaa acagcgaccg acacugugaa aagugagauu aaugcugaac uugguguggu     2400

cccuagcuua aaugcaguug aaacaggugc aacuucuaac acugaaccag aagaagccau     2460

acaaacucgc acagugauaa aucagcacgg uguauccgag acucuagugg agaauuuucu     2520

caguagagca gcuuugguau caaagagaag uuuugaauac aaagaucaua cuucgucugc     2580

agcacaagca gacaagaacu uuuucaaaug gacaauuaac accagauccu uuguacaguu     2640

aagaagaaaa uuagaauuau ucacauaccu uagauuugau gcugagauca cuauacucac     2700

aacuguagca gugaauggua gugguaauaa uacauacgug ggucuuccug acuugacacu     2760

ccaagcaaug uuuguaccca cuggugcucu uaccccagaa aaacaggacu cauuccacug     2820

gcagucaggc aguaaugcua guguauucuu uaaaaucucc gaccccccag ccagaauaac     2880

cauaccuuuu augugcauua acucagcaua cucaguuuuu uaugauggcu uugccggauu     2940

ugagaaaaac ggucuguaug gaauaaaucc agcugacacu auugguaacu uauguguuag     3000

aauagugaau gaacaccaac caguugguuu cacagugacc guuaggguuu acaugaagcc     3060

uaaacacaua aaagcauggg caccacgacc accacgaacu uugccauaua ugaguauugc     3120

aaaugcaaau uacaaaggua aagaaagagc accaaaugcg cucaaugcua uaauuggcaa     3180

uagagacagu gucaaaacca ugccucauaa uauagugaac acugguccag gcuucggagg     3240

aguuuuugua gggucuuuca aaauaaucaa cuaucacuug gccacuacag aagagagaca     3300

gucagcuauc uauguggauu ggcaaucaga cgucuugguu acccccauug cugcucaugg     3360

aaggcaccaa auagcaagau gcaagugcaa cacagggguu uacuauugua ggcacaaaaa     3420

cagaaguuac ccgauuugcu uugaaggccc agggauucaa uggauugaac aaaaugaaua     3480

uuacccagca agguaccaga ccaauguacu auuggcaguu gguccugcgg aagcaggaga     3540

uugcgguggu uuacuaguuu guccacaugg gguaaucggu cuucuuacag caggaggggg     3600

uggaauugua gcuuucacug auaucaggaa uuugcuaugg uuagauacug augcuaugga     3660

acaaggcauu acugauuaua uucaaaaucu ugguaaugcc uuuggagcag gauuuacaga     3720

aacaaucucu aauaaagcca aggaagugca agauaugcua auuggagaga guucacuauu     3780

agaaaaauug uuaaaagcuc uaaucaaaau cauaucagca uuaguaauug uaaucagaaa     3840

cucagaagau uuagucacag ucacagccac acuagcauug uugggaugcc augauucacc     3900

auggagcuac uugaaacaga agguauguuc auacuuaggu auuccuuaug uaccuagaca     3960

gggugaaucg uggcuuaaga aauucacaga ggcaugcaau gcucuuagag gucuggauug     4020

gcuaucgcaa aagauagaua aauucaucaa cuggcuuaaa accaaaauau uaccagaagc     4080

uagggagaaa uaugaauuug ugcaaaggcu caaacaguua ccggugauag aaaaccaagu     4140

uaguacaauc gagcauagcu gcccaacaac agaacaacaa caggccuuau ucaacaacgu     4200

ccaauacuau ucacacuacu guagaaagua cgcaccacuu uacgcagugg aagcaaagag     4260

gguaguagcu cuugaaaaga aaauaaacaa cuacauccag uucaagucca aaucucgcau     4320

ugaaccgguu uguuuaauaa uacauggcuc uccaggaacu ggcaagucag uggcuucaaa     4380

uuuaauugcc agggcuauca cagagaaauu ggggggggac auuuauuccu ugccuccaga     4440

cccuaaauau uuugauggau acaaacagca aacagugguc cucauggaug auuuaaugca     4500

aaauccagau gggaaugaca uaucuauguu cugccaaaug gucuccacug uagauuucau     4560

acccccaaug gcuaguuugg aggaaaaagg aacucuauac accaguccau uuuuaauagc     4620

uacuaccaau gcuggcucaa uacaugcacc aacuguauca gacucaaagg cuuugucacg     4680

cagauuuaaa uuugacgugg acauugaagu cacagauuca uacaaggacu caaauaaauu     4740

ggauauguca agggcagucg agaugugcaa accagauggc ugugccccca ccaauuacaa     4800

aagaugcugc ccauugaucu guggaaaggc uauccaauuc agagaucgca gaacuaaugc     4860

aagauccacu auugauaugc uaguaacuga uauuauaaag gaauauagaa ccagaaacag     4920

uacacaggau aagcuggaag cucuguuuca ggggccucca caguuuaaag agaucaaaau     4980

uucagucacc ccagauacac cagcuccuga ugcuauaaau gaccuucuua ggucagugga     5040

uucucaagaa guuagggauu auugccaaaa gaaaggaugg auuguaguac acccaucaaa     5100

ugagcuaaua guagaaaaac acauuaguag agcuuuuauu acucuacaag ccauugccac     5160

cuuuguauca auagcuggug uaguuuaugu uauauacaaa cuuuuugcug gcauucaggg     5220

uccauacaca ggaaucccca auccuaaacc uaaaguaccc ucucucagaa cagcuaaagu     5280

gcaaggacca ggguucgauu uugcacaagc cauaaugaag aaaaauaccg ucauugcaag     5340

gacugaaaag ggugaguuca ccaugcuggg uguauaugau aggguagcgg ucauccccac     5400

acacgcaucu guuggagaaa ccauuuacau uaaugaugua gagacuaaag uuuuagaugc     5460

gugugcacuu agagacuuga cugauacaaa cuuagagaua accauaguca aauuagaccg     5520

uaaucaaaaa uuuagagaua ucagacauuu ucugcccaga uaugaggaug auuacaauga     5580

cgcugugcuu agcguacaua caucaaaauu cccaaauaug uauaucccag uuggacaagu     5640

caccaauuau ggcuucuuga accuaggugg uacaccgacg caccgcauuu uaauguauaa     5700

cuucccaaca agagcuggcc aguguggugg uguggugaca acuacaggua aggugauagg     5760

aauacaugua gguggaaaug gagcucaagg auuugcagca augcuacuac acucuuacuu     5820

uuccgauaca caaggugaga uaguuaguag ugaaaagagu ggggugugca uuaacgcacc     5880

ggcaaagacu aaacuccaac cuaguguuuu ccaucaaguu uuugaagguu caaaggaacc     5940

agcaguucuc aauccaaaag auccuaggcu uaaaacagau uucgaggagg ccauuuucuc     6000

aaaguacaca gguaacaaaa uuauguuaau ggaugaguac auggaagagg caguggauca     6060

uuaugugggg uguuuagaac cauuagacau caguguggau cccauacccc uggaaagugc     6120

cauguaugga auggauggcc uugaggcauu agacuuaacu accagugcag gauucccuua     6180

cuuacuacaa gggaagaaga aaagggauau auuuaauaga cauacuagag acaccaguga     6240

aaugacaaaa auguuagaga aauauggagu ugaccuaccu uuuguaaccu uuguaaaaga     6300

ugagcuuaga ucaagagaaa aaguugaaaa agggaaauca cgccugauug aggccaguuc     6360

cuugaaugac ucaguugcua ugagaguugc cuuuggaaac cuuuacgcca cauuucacaa     6420

caauccaggu acagcaacug guagugcagu ugguugugau ccagauauau uuuggucaaa     6480

aaucccuauu uuguuagaug gagaaaucuu ugcuuuugac uacacugguu augaugcuag     6540

uuugucacca gugugguuug ccugcuuaaa gaaaguucua auuaaguuag guuacacaca     6600

ucaaacgucu uuuauagauu auuuguguca uucaguacau uuauauaagg acaaaaaaua     6660

cauaguuaau gguggaaugc ccucugguuc uucaggcacc agcauauuca acacuaugau     6720

caacaauaua aucauaagaa cuuuauuaau uaggguuuac aaaggcauag accuggacca     6780

guucaaaaug auugccuaug gggaugaugu uauugcuagc uacccacaua agauugaucc     6840

agguuugcug gcagaagcag guaaacagua uggauuagua augacgccag cagacaaagg     6900

aaccaguuuu auugacacaa auugggaaaa uguaacuuuc uuaaaaagau auuucagagc     6960

agaugaucaa uaccccuuuc ucauacaucc agugaugcca augaaagaga uacaugaauc     7020

uauuagaugg acuaaagauc ccagaaacac acaggaucau guuaggucuu ugugcuaccu     7080

cgcauggcau aauggagagg aggcuuauaa ugaauuuugc agaaaaauca gaagugugcc     7140

ugugggaaga gcauugacac uaccugcaua cucuagucuu agacggaaau gguuagauuc     7200

guucuagaca acucuaauug aaacccaagu uauaguuacu uucauuuaga gguaaauuuu     7260

ggucacuugg gggccaaaaa aaaaaaaaaa aaaaaaaaaa gucgac                    7306


<210>  14
<211>  7485
<212>  RNA
<213>  人工序列

<220>
<223>  EV-D68-miR133&206T的基因组序列

<400>  14
uaauacgacu cacuauaggu uaaaacagcc uugggguugu ucccacucca agggcccacg       60

uggcggcuag uacucuggua cuucgguacc uuuguacgcc uguuuuaucu cccuucccaa      120

uguaacuuag aaguucuuaa aucaaugcuc aauagguggg gcgcaaacca gcgcucucau      180

gagcaagcac uccugucucc ccggugaggu uguauaaacu guucccacgg uugaaaacaa      240

ccuauccguu auccgcuaua guacuucgag aaaccuagua ccaccuuugg auuguugacg      300

cguugcgcuc agcacacuaa cccgugugua gcuugggucg augagucugg acauaccuca      360

cuggcgacag ugguccaggc ugcguuggcg gccuacucau ggugaaagcc augagacgcu      420

agacaugaac aaggugugaa gagucuauug agcuacuaua gaguccuccg gccccugaau      480

gcggcuaauc cuaaccaugg agcaagugcu cacaggccag ugaguugcuu gucguaaugc      540

gcaaguccgu ggcggaaccg acuacuuugg guguccgugu uucacuuuuu acuuuuauga      600

cugcuuaugg ugacaauuug auauuguuac cauuuagcuu gucaaaucaa uugcaaaaga      660

uccuaaaucu uauuuaucaa cuugcaucuu gauaacuuua auuugaaaau uuuaacaaug      720

ggagcucagg uuacuagaca acaaacuggc acucaugaaa augccaacau ugccacaaau      780

ggaucucaua ucacauacaa ucagauaaac uuuuacaagg auagcuaugc ggcuucagcc      840

agcaagcagg auuuuucaca ggacccauca aaauucacug aaccaguagu ggaagguuua      900

aaagcagggg cgccaguuuu gaaaucuccu agugcugagg cauguggcua cagugauaga      960

guauuacagc ucaaauuagg aaauucagcu auugucaccc aggaagcagc gaacuacugc     1020

ugcgcuuaug gugaauggcc caauuacuua ccagaccaug aagcaguagc cauugauaaa     1080

ccuacacaac cagaaacugc uacagauaga uucuacacuu ugaaaucagu caaaugggaa     1140

acuggaagca caggauggug guggaaacua cccgaugcac ugaauaauau aggcauguuu     1200

ggacagaaug ugcagcauca cuaccuauau agaucugguu ucuugauuca ugugcagugu     1260

aaugccacaa aauuccauca aggugccuua uuagugguag caauuccaga acaucagagg     1320

ggagcgcaca acaccaacac uagcccaggg uuugaugaua uaaugaaagg ugaagaagga     1380

gggaccuuca aucauccaua uguccuugau gauggaacau cauuggcuug ugcgacgaua     1440

uuuccacauc aguggauaaa ucugagaacc aacaauucag caacaauugu ucuucccugg     1500

augaaugcug cuccaaugga uuucccacuu agacauaauc aguggacgcu agcaauaaua     1560

ccaguggugc cauuagguac gcguacaaca ucaaguaugg ucccaauaac aguuucaauc     1620

gcuccaaugu guugugaguu uaauggacuu agacacgcca uuacucaagg ugucccaaca     1680

uaccuuuuac caggcucggg acaauuccua acaacugaug aucauagcuc ugcaccagcu     1740

cucccguguu ucaacccaac uccagaaaug cauaucccag ggcagguccg uaacaugcua     1800

gaaguggucc aaguggaauc aaugauggag auuaauaaca cagaaagugc aguuggcaug     1860

gagcgucuua agguugauau aucagcauug acagaugucg aucaauuguu auucaacauu     1920

ccacuggaca uacaguugga ugggccacuu agaaacacuu ugguaggaaa cauaucuaga     1980

uauuacacuc auuggucugg aucccuagaa augacguuua uguuuugugg cagcuucaug     2040

gcaacgggaa aauuaauccu gugcuauacu ccuccaggug gaucaugccc gacaaccaga     2100

gagaccgcca uguuagguac acauauuguu ugggauuuug gauuacaauc uaguguaacc     2160

cugauaauac cuuggauuag uggaucccac uacaggaugu uuaauaauga ugcuaaguca     2220

acuaaugcca acguuggcua ugucacuugu uuuaugcaga ccaaucugau aguccccagu     2280

gaauccucug acacguguuc cuugauaggg uucauagcag caaaagauga uuucucccuc     2340

agauuaauga gagacagccc ugacauugga caacuagacc auuuacaugc agcagaggca     2400

gccuaccaga ucgagagcau caucaaaaca gcgaccgaca cugugaaaag ugagauuaau     2460

gcugaacuug gugugguccc uagcuuaaau gcaguugaaa caggugcaac uucuaacacu     2520

gaaccagaag aagccauaca aacucgcaca gugauaaauc agcacggugu auccgagacu     2580

cuaguggaga auuuucucag uagagcagcu uugguaucaa agagaaguuu ugaauacaaa     2640

gaucauacuu cgucugcagc acaagcagac aagaacuuuu ucaaauggac aauuaacacc     2700

agauccuuug uacaguuaag aagaaaauua gaauuauuca cauaccuuag auuugaugcu     2760

gagaucacua uacucacaac uguagcagug aaugguagug guaauaauac auacgugggu     2820

cuuccugacu ugacacucca agcaauguuu guacccacug gugcucuuac cccagaaaaa     2880

caggacucau uccacuggca gucaggcagu aaugcuagug uauucuuuaa aaucuccgac     2940

cccccagcca gaauaaccau accuuuuaug ugcauuaacu cagcauacuc aguuuuuuau     3000

gauggcuuug ccggauuuga gaaaaacggu cuguauggaa uaaauccagc ugacacuauu     3060

gguaacuuau guguuagaau agugaaugaa caccaaccag uugguuucac agugaccguu     3120

aggguuuaca ugaagccuaa acacauaaaa gcaugggcac cacgaccacc acgaacuuug     3180

ccauauauga guauugcaaa ugcaaauuac aaagguaaag aaagagcacc aaaugcgcuc     3240

aaugcuauaa uuggcaauag agacaguguc aaaaccaugc cucauaauau agugaacacu     3300

gguccaggcu ucggaggagu uuuuguaggg ucuuucaaaa uaaucaacua ucacuuggcc     3360

acuacagaag agagacaguc agcuaucuau guggauuggc aaucagacgu cuugguuacc     3420

cccauugcug cucauggaag gcaccaaaua gcaagaugca agugcaacac agggguuuac     3480

uauuguaggc acaaaaacag aaguuacccg auuugcuuug aaggcccagg gauucaaugg     3540

auugaacaaa augaauauua cccagcaagg uaccagacca auguacuauu ggcaguuggu     3600

ccugcggaag caggagauug cggugguuua cuaguuuguc cacauggggu aaucggucuu     3660

cuuacagcag gagggggugg aauuguagcu uucacugaua ucaggaauuu gcuaugguua     3720

gauacugaug cuauggaaca aggcauuacu gauuauauuc aaaaucuugg uaaugccuuu     3780

ggagcaggau uuacagaaac aaucucuaau aaagccaagg aagugcaaga uaugcuaauu     3840

ggagagaguu cacuauuaga aaaauuguua aaagcucuaa ucaaaaucau aucagcauua     3900

guaauuguaa ucagaaacuc agaagauuua gucacaguca cagccacacu agcauuguug     3960

ggaugccaug auucaccaug gagcuacuug aaacagaagg uauguucaua cuuagguauu     4020

ccuuauguac cuagacaggg ugaaucgugg cuuaagaaau ucacagaggc augcaaugcu     4080

cuuagagguc uggauuggcu aucgcaaaag auagauaaau ucaucaacug gcuuaaaacc     4140

aaaauauuac cagaagcuag ggagaaauau gaauuugugc aaaggcucaa acaguuaccg     4200

gugauagaaa accaaguuag uacaaucgag cauagcugcc caacaacaga acaacaacag     4260

gccuuauuca acaacgucca auacuauuca cacuacugua gaaaguacgc accacuuuac     4320

gcaguggaag caaagagggu aguagcucuu gaaaagaaaa uaaacaacua cauccaguuc     4380

aaguccaaau cucgcauuga accgguuugu uuaauaauac auggcucucc aggaacuggc     4440

aagucagugg cuucaaauuu aauugccagg gcuaucacag agaaauuggg gggggacauu     4500

uauuccuugc cuccagaccc uaaauauuuu gauggauaca aacagcaaac agugguccuc     4560

auggaugauu uaaugcaaaa uccagauggg aaugacauau cuauguucug ccaaaugguc     4620

uccacuguag auuucauacc cccaauggcu aguuuggagg aaaaaggaac ucuauacacc     4680

aguccauuuu uaauagcuac uaccaaugcu ggcucaauac augcaccaac uguaucagac     4740

ucaaaggcuu ugucacgcag auuuaaauuu gacguggaca uugaagucac agauucauac     4800

aaggacucaa auaaauugga uaugucaagg gcagucgaga ugugcaaacc agauggcugu     4860

gcccccacca auuacaaaag augcugccca uugaucugug gaaaggcuau ccaauucaga     4920

gaucgcagaa cuaaugcaag auccacuauu gauaugcuag uaacugauau uauaaaggaa     4980

uauagaacca gaaacaguac acaggauaag cuggaagcuc uguuucaggg gccuccacag     5040

uuuaaagaga ucaaaauuuc agucacccca gauacaccag cuccugaugc uauaaaugac     5100

cuucuuaggu caguggauuc ucaagaaguu agggauuauu gccaaaagaa aggauggauu     5160

guaguacacc caucaaauga gcuaauagua gaaaaacaca uuaguagagc uuuuauuacu     5220

cuacaagcca uugccaccuu uguaucaaua gcugguguag uuuauguuau auacaaacuu     5280

uuugcuggca uucagggucc auacacagga auccccaauc cuaaaccuaa aguacccucu     5340

cucagaacag cuaaagugca aggaccaggg uucgauuuug cacaagccau aaugaagaaa     5400

aauaccguca uugcaaggac ugaaaagggu gaguucacca ugcugggugu auaugauagg     5460

guagcgguca uccccacaca cgcaucuguu ggagaaacca uuuacauuaa ugauguagag     5520

acuaaaguuu uagaugcgug ugcacuuaga gacuugacug auacaaacuu agagauaacc     5580

auagucaaau uagaccguaa ucaaaaauuu agagauauca gacauuuucu gcccagauau     5640

gaggaugauu acaaugacgc ugugcuuagc guacauacau caaaauuccc aaauauguau     5700

aucccaguug gacaagucac caauuauggc uucuugaacc uaggugguac accgacgcac     5760

cgcauuuuaa uguauaacuu cccaacaaga gcuggccagu gugguggugu ggugacaacu     5820

acagguaagg ugauaggaau acauguaggu ggaaauggag cucaaggauu ugcagcaaug     5880

cuacuacacu cuuacuuuuc cgauacacaa ggugagauag uuaguaguga aaagaguggg     5940

gugugcauua acgcaccggc aaagacuaaa cuccaaccua guguuuucca ucaaguuuuu     6000

gaagguucaa aggaaccagc aguucucaau ccaaaagauc cuaggcuuaa aacagauuuc     6060

gaggaggcca uuuucucaaa guacacaggu aacaaaauua uguuaaugga ugaguacaug     6120

gaagaggcag uggaucauua uguggggugu uuagaaccau uagacaucag uguggauccc     6180

auaccccugg aaagugccau guauggaaug gauggccuug aggcauuaga cuuaacuacc     6240

agugcaggau ucccuuacuu acuacaaggg aagaagaaaa gggauauauu uaauagacau     6300

acuagagaca ccagugaaau gacaaaaaug uuagagaaau auggaguuga ccuaccuuuu     6360

guaaccuuug uaaaagauga gcuuagauca agagaaaaag uugaaaaagg gaaaucacgc     6420

cugauugagg ccaguuccuu gaaugacuca guugcuauga gaguugccuu uggaaaccuu     6480

uacgccacau uucacaacaa uccagguaca gcaacuggua gugcaguugg uugugaucca     6540

gauauauuuu ggucaaaaau cccuauuuug uuagauggag aaaucuuugc uuuugacuac     6600

acugguuaug augcuaguuu gucaccagug ugguuugccu gcuuaaagaa aguucuaauu     6660

aaguuagguu acacacauca aacgucuuuu auagauuauu ugugucauuc aguacauuua     6720

uauaaggaca aaaaauacau aguuaauggu ggaaugcccu cugguucuuc aggcaccagc     6780

auauucaaca cuaugaucaa caauauaauc auaagaacuu uauuaauuag gguuuacaaa     6840

ggcauagacc uggaccaguu caaaaugauu gccuaugggg augauguuau ugcuagcuac     6900

ccacauaaga uugauccagg uuugcuggca gaagcaggua aacaguaugg auuaguaaug     6960

acgccagcag acaaaggaac caguuuuauu gacacaaauu gggaaaaugu aacuuucuua     7020

aaaagauauu ucagagcaga ugaucaauac cccuuucuca uacauccagu gaugccaaug     7080

aaagagauac augaaucuau uagauggacu aaagauccca gaaacacaca ggaucauguu     7140

aggucuuugu gcuaccucgc auggcauaau ggagaggagg cuuauaauga auuuugcaga     7200

aaaaucagaa gugugccugu gggaagagca uugacacuac cugcauacuc uagucuuaga     7260

cggaaauggu uagauucguu cuagacaacu cuaacagcug guugaagggg accaacgaua     7320

cagcugguug aaggggacca aaccggucca cacacuuccu uacauuccau cacccacaca     7380

cuuccuuaca uuccaauuga aacccaaguu auaguuacuu ucauuuagag guaaauuuug     7440

gucacuuggg ggccaaaaaa aaaaaaaaaa aaaaaaaaag ucgac                     7485


<210>  15
<211>  7860
<212>  RNA
<213>  人工序列

<220>
<223>  EV-D68-GM-CSF的基因组序列

<400>  15
uaauacgacu cacuauaggu uaaaacagcc uugggguugu ucccacucca agggcccacg       60

uggcggcuag uacucuggua cuucgguacc uuuguacgcc uguuuuaucu cccuucccaa      120

uguaacuuag aaguucuuaa aucaaugcuc aauagguggg gcgcaaacca gcgcucucau      180

gagcaagcac uccugucucc ccggugaggu uguauaaacu guucccacgg uugaaaacaa      240

ccuauccguu auccgcuaua guacuucgag aaaccuagua ccaccuuugg auuguugacg      300

cguugcgcuc agcacacuaa cccgugugua gcuugggucg augagucugg acauaccuca      360

cuggcgacag ugguccaggc ugcguuggcg gccuacucau ggugaaagcc augagacgcu      420

agacaugaac aaggugugaa gagucuauug agcuacuaua gaguccuccg gccccugaau      480

gcggcuaauc cuaaccaugg agcaagugcu cacaggccag ugaguugcuu gucguaaugc      540

gcaaguccgu ggcggaaccg acuacuuugg guguccgugu uucacuuuuu acuuuuauga      600

cugcuuaugg ugacaauuug auauuguuac cauuuagcuu gucaaaucaa uugcaaaaga      660

uccuaaaucu uauuuaucaa cuugcaucuu gauaacuuua auuugaaaau uuuaacaaug      720

ggagcucagg uuacuagaca acaaacuggc acucaugaaa augccaacau ugccacaaau      780

ggaucucaua ucacauacaa ucagauaaac uuuuacaagg auagcuaugc ggcuucagcc      840

agcaagcagg auuuuucaca ggacccauca aaauucacug aaccaguagu ggaagguuua      900

aaagcagggg cgccaguuuu gaaaucuccu agugcugagg cauguggcua cagugauaga      960

guauuacagc ucaaauuagg aaauucagcu auugucaccc aggaagcagc gaacuacugc     1020

ugcgcuuaug gugaauggcc caauuacuua ccagaccaug aagcaguagc cauugauaaa     1080

ccuacacaac cagaaacugc uacagauaga uucuacacuu ugaaaucagu caaaugggaa     1140

acuggaagca caggauggug guggaaacua cccgaugcac ugaauaauau aggcauguuu     1200

ggacagaaug ugcagcauca cuaccuauau agaucugguu ucuugauuca ugugcagugu     1260

aaugccacaa aauuccauca aggugccuua uuagugguag caauuccaga acaucagagg     1320

ggagcgcaca acaccaacac uagcccaggg uuugaugaua uaaugaaagg ugaagaagga     1380

gggaccuuca aucauccaua uguccuugau gauggaacau cauuggcuug ugcgacgaua     1440

uuuccacauc aguggauaaa ucugagaacc aacaauucag caacaauugu ucuucccugg     1500

augaaugcug cuccaaugga uuucccacuu agacauaauc aguggacgcu agcaauaaua     1560

ccaguggugc cauuagguac gcguacaaca ucaaguaugg ucccaauaac aguuucaauc     1620

gcuccaaugu guugugaguu uaauggacuu agacacgcca uuacucaagg ugucccaaca     1680

uaccuuuuac caggcucggg acaauuccua acaacugaug aucauagcuc ugcaccagcu     1740

cucccguguu ucaacccaac uccagaaaug cauaucccag ggcagguccg uaacaugcua     1800

gaaguggucc aaguggaauc aaugauggag auuaauaaca cagaaagugc aguuggcaug     1860

gagcgucuua agguugauau aucagcauug acagaugucg aucaauuguu auucaacauu     1920

ccacuggaca uacaguugga ugggccacuu agaaacacuu ugguaggaaa cauaucuaga     1980

uauuacacuc auuggucugg aucccuagaa augacguuua uguuuugugg cagcuucaug     2040

gcaacgggaa aauuaauccu gugcuauacu ccuccaggug gaucaugccc gacaaccaga     2100

gagaccgcca uguuagguac acauauuguu ugggauuuug gauuacaauc uaguguaacc     2160

cugauaauac cuuggauuag uggaucccac uacaggaugu uuaauaauga ugcuaaguca     2220

acuaaugcca acguuggcua ugucacuugu uuuaugcaga ccaaucugau aguccccagu     2280

gaauccucug acacguguuc cuugauaggg uucauagcag caaaagauga uuucucccuc     2340

agauuaauga gagacagccc ugacauugga caacuagacc auuuacaugc agcagaggca     2400

gccuaccaga ucgagagcau caucaaaaca gcgaccgaca cugugaaaag ugagauuaau     2460

gcugaacuug gugugguccc uagcuuaaau gcaguugaaa caggugcaac uucuaacacu     2520

gaaccagaag aagccauaca aacucgcaca gugauaaauc agcacggugu auccgagacu     2580

cuaguggaga auuuucucag uagagcagcu uugguaucaa agagaaguuu ugaauacaaa     2640

gaucauacuu cgucugcagc acaagcagac aagaacuuuu ucaaauggac aauuaacacc     2700

agauccuuug uacaguuaag aagaaaauua gaauuauuca cauaccuuag auuugaugcu     2760

gagaucacua uacucacaac uguagcagug aaugguagug guaauaauac auacgugggu     2820

cuuccugacu ugacacucca agcaauguuu guacccacug gugcucuuac cccagaaaaa     2880

caggacucau uccacuggca gucaggcagu aaugcuagug uauucuuuaa aaucuccgac     2940

cccccagcca gaauaaccau accuuuuaug ugcauuaacu cagcauacuc aguuuuuuau     3000

gauggcuuug ccggauuuga gaaaaacggu cuguauggaa uaaauccagc ugacacuauu     3060

gguaacuuau guguuagaau agugaaugaa caccaaccag uugguuucac agugaccguu     3120

aggguuuaca ugaagccuaa acacauaaaa gcaugggcac cacgaccacc acgaacuuug     3180

ccauauauga guauugcaaa ugcaaauuac aaagguaaag aaagagcacc aaaugcgcuc     3240

aaugcuauaa uuggcaauag agacaguguc aaaaccaugc cucauaauau agugaacacu     3300

gguccaggcu ucuggcugca gagccugcug cucuugggca cuguggccug cagcaucucu     3360

gcacccgccc gcucgcccag ccccagcacg cagcccuggg agcaugugaa ugccauccag     3420

gaggcccggc gucuccugaa ccugaguaga gacacugcug cugagaugaa ugaaacagua     3480

gaagucaucu cagaaauguu ugaccuccag gagccgaccu gccuacagac ccgccuggag     3540

cuguacaagc agggccugcg gggcagccuc accaagcuca agggccccuu gaccaugaug     3600

gccagccacu acaagcagca cugcccucca accccggaaa cuuccugugc aacccagauu     3660

aucaccuuug aaaguuucaa agagaaccug aaggacuuuc ugcuugucau ccccuuugac     3720

ugcugggagc caguccagga gagugucaaa accaugccuc auaauauagu gaacacuggu     3780

ccaggcuucg gaggaguuuu uguagggucu uucaaaauaa ucaacuauca cuuggccacu     3840

acagaagaga gacagucagc uaucuaugug gauuggcaau cagacgucuu gguuaccccc     3900

auugcugcuc auggaaggca ccaaauagca agaugcaagu gcaacacagg gguuuacuau     3960

uguaggcaca aaaacagaag uuacccgauu ugcuuugaag gcccagggau ucaauggauu     4020

gaacaaaaug aauauuaccc agcaagguac cagaccaaug uacuauuggc aguugguccu     4080

gcggaagcag gagauugcgg ugguuuacua guuuguccac augggguaau cggucuucuu     4140

acagcaggag gggguggaau uguagcuuuc acugauauca ggaauuugcu augguuagau     4200

acugaugcua uggaacaagg cauuacugau uauauucaaa aucuugguaa ugccuuugga     4260

gcaggauuua cagaaacaau cucuaauaaa gccaaggaag ugcaagauau gcuaauugga     4320

gagaguucac uauuagaaaa auuguuaaaa gcucuaauca aaaucauauc agcauuagua     4380

auuguaauca gaaacucaga agauuuaguc acagucacag ccacacuagc auuguuggga     4440

ugccaugauu caccauggag cuacuugaaa cagaagguau guucauacuu agguauuccu     4500

uauguaccua gacaggguga aucguggcuu aagaaauuca cagaggcaug caaugcucuu     4560

agaggucugg auuggcuauc gcaaaagaua gauaaauuca ucaacuggcu uaaaaccaaa     4620

auauuaccag aagcuaggga gaaauaugaa uuugugcaaa ggcucaaaca guuaccggug     4680

auagaaaacc aaguuaguac aaucgagcau agcugcccaa caacagaaca acaacaggcc     4740

uuauucaaca acguccaaua cuauucacac uacuguagaa aguacgcacc acuuuacgca     4800

guggaagcaa agaggguagu agcucuugaa aagaaaauaa acaacuacau ccaguucaag     4860

uccaaaucuc gcauugaacc gguuuguuua auaauacaug gcucuccagg aacuggcaag     4920

ucaguggcuu caaauuuaau ugccagggcu aucacagaga aauugggggg ggacauuuau     4980

uccuugccuc cagacccuaa auauuuugau ggauacaaac agcaaacagu gguccucaug     5040

gaugauuuaa ugcaaaaucc agaugggaau gacauaucua uguucugcca aauggucucc     5100

acuguagauu ucauaccccc aauggcuagu uuggaggaaa aaggaacucu auacaccagu     5160

ccauuuuuaa uagcuacuac caaugcuggc ucaauacaug caccaacugu aucagacuca     5220

aaggcuuugu cacgcagauu uaaauuugac guggacauug aagucacaga uucauacaag     5280

gacucaaaua aauuggauau gucaagggca gucgagaugu gcaaaccaga uggcugugcc     5340

cccaccaauu acaaaagaug cugcccauug aucuguggaa aggcuaucca auucagagau     5400

cgcagaacua augcaagauc cacuauugau augcuaguaa cugauauuau aaaggaauau     5460

agaaccagaa acaguacaca ggauaagcug gaagcucugu uucaggggcc uccacaguuu     5520

aaagagauca aaauuucagu caccccagau acaccagcuc cugaugcuau aaaugaccuu     5580

cuuaggucag uggauucuca agaaguuagg gauuauugcc aaaagaaagg auggauugua     5640

guacacccau caaaugagcu aauaguagaa aaacacauua guagagcuuu uauuacucua     5700

caagccauug ccaccuuugu aucaauagcu gguguaguuu auguuauaua caaacuuuuu     5760

gcuggcauuc aggguccaua cacaggaauc cccaauccua aaccuaaagu acccucucuc     5820

agaacagcua aagugcaagg accaggguuc gauuuugcac aagccauaau gaagaaaaau     5880

accgucauug caaggacuga aaagggugag uucaccaugc uggguguaua ugauagggua     5940

gcggucaucc ccacacacgc aucuguugga gaaaccauuu acauuaauga uguagagacu     6000

aaaguuuuag augcgugugc acuuagagac uugacugaua caaacuuaga gauaaccaua     6060

gucaaauuag accguaauca aaaauuuaga gauaucagac auuuucugcc cagauaugag     6120

gaugauuaca augacgcugu gcuuagcgua cauacaucaa aauucccaaa uauguauauc     6180

ccaguuggac aagucaccaa uuauggcuuc uugaaccuag gugguacacc gacgcaccgc     6240

auuuuaaugu auaacuuccc aacaagagcu ggccagugug gugguguggu gacaacuaca     6300

gguaagguga uaggaauaca uguaggugga aauggagcuc aaggauuugc agcaaugcua     6360

cuacacucuu acuuuuccga uacacaaggu gagauaguua guagugaaaa gaguggggug     6420

ugcauuaacg caccggcaaa gacuaaacuc caaccuagug uuuuccauca aguuuuugaa     6480

gguucaaagg aaccagcagu ucucaaucca aaagauccua ggcuuaaaac agauuucgag     6540

gaggccauuu ucucaaagua cacagguaac aaaauuaugu uaauggauga guacauggaa     6600

gaggcagugg aucauuaugu gggguguuua gaaccauuag acaucagugu ggaucccaua     6660

ccccuggaaa gugccaugua uggaauggau ggccuugagg cauuagacuu aacuaccagu     6720

gcaggauucc cuuacuuacu acaagggaag aagaaaaggg auauauuuaa uagacauacu     6780

agagacacca gugaaaugac aaaaauguua gagaaauaug gaguugaccu accuuuugua     6840

accuuuguaa aagaugagcu uagaucaaga gaaaaaguug aaaaagggaa aucacgccug     6900

auugaggcca guuccuugaa ugacucaguu gcuaugagag uugccuuugg aaaccuuuac     6960

gccacauuuc acaacaaucc agguacagca acugguagug caguugguug ugauccagau     7020

auauuuuggu caaaaauccc uauuuuguua gauggagaaa ucuuugcuuu ugacuacacu     7080

gguuaugaug cuaguuuguc accagugugg uuugccugcu uaaagaaagu ucuaauuaag     7140

uuagguuaca cacaucaaac gucuuuuaua gauuauuugu gucauucagu acauuuauau     7200

aaggacaaaa aauacauagu uaauggugga augcccucug guucuucagg caccagcaua     7260

uucaacacua ugaucaacaa uauaaucaua agaacuuuau uaauuagggu uuacaaaggc     7320

auagaccugg accaguucaa aaugauugcc uauggggaug auguuauugc uagcuaccca     7380

cauaagauug auccagguuu gcuggcagaa gcagguaaac aguauggauu aguaaugacg     7440

ccagcagaca aaggaaccag uuuuauugac acaaauuggg aaaauguaac uuucuuaaaa     7500

agauauuuca gagcagauga ucaauacccc uuucucauac auccagugau gccaaugaaa     7560

gagauacaug aaucuauuag auggacuaaa gaucccagaa acacacagga ucauguuagg     7620

ucuuugugcu accucgcaug gcauaaugga gaggaggcuu auaaugaauu uugcagaaaa     7680

aucagaagug ugccuguggg aagagcauug acacuaccug cauacucuag ucuuagacgg     7740

aaaugguuag auucguucua gacaacucua auugaaaccc aaguuauagu uacuuucauu     7800

uagagguaaa uuuuggucac uugggggcca aaaaaaaaaa aaaaaaaaaa aaaagucgac     7860


<210>  16
<211>  8226
<212>  RNA
<213>  人工序列

<220>
<223>  EV-D68-Anti-PD1的基因组序列

<400>  16
uaauacgacu cacuauaggu uaaaacagcc uugggguugu ucccacucca agggcccacg       60

uggcggcuag uacucuggua cuucgguacc uuuguacgcc uguuuuaucu cccuucccaa      120

uguaacuuag aaguucuuaa aucaaugcuc aauagguggg gcgcaaacca gcgcucucau      180

gagcaagcac uccugucucc ccggugaggu uguauaaacu guucccacgg uugaaaacaa      240

ccuauccguu auccgcuaua guacuucgag aaaccuagua ccaccuuugg auuguugacg      300

cguugcgcuc agcacacuaa cccgugugua gcuugggucg augagucugg acauaccuca      360

cuggcgacag ugguccaggc ugcguuggcg gccuacucau ggugaaagcc augagacgcu      420

agacaugaac aaggugugaa gagucuauug agcuacuaua gaguccuccg gccccugaau      480

gcggcuaauc cuaaccaugg agcaagugcu cacaggccag ugaguugcuu gucguaaugc      540

gcaaguccgu ggcggaaccg acuacuuugg guguccgugu uucacuuuuu acuuuuauga      600

cugcuuaugg ugacaauuug auauuguuac cauuuagcuu gucaaaucaa uugcaaaaga      660

uccuaaaucu uauuuaucaa cuugcaucuu gauaacuuua auuugaaaau uuuaacaaug      720

ggagcucagg uuacuagaca acaaacuggc acucaugaaa augccaacau ugccacaaau      780

ggaucucaua ucacauacaa ucagauaaac uuuuacaagg auagcuaugc ggcuucagcc      840

agcaagcagg auuuuucaca ggacccauca aaauucacug aaccaguagu ggaagguuua      900

aaagcagggg cgccaguuuu gaaaucuccu agugcugagg cauguggcua cagugauaga      960

guauuacagc ucaaauuagg aaauucagcu auugucaccc aggaagcagc gaacuacugc     1020

ugcgcuuaug gugaauggcc caauuacuua ccagaccaug aagcaguagc cauugauaaa     1080

ccuacacaac cagaaacugc uacagauaga uucuacacuu ugaaaucagu caaaugggaa     1140

acuggaagca caggauggug guggaaacua cccgaugcac ugaauaauau aggcauguuu     1200

ggacagaaug ugcagcauca cuaccuauau agaucugguu ucuugauuca ugugcagugu     1260

aaugccacaa aauuccauca aggugccuua uuagugguag caauuccaga acaucagagg     1320

ggagcgcaca acaccaacac uagcccaggg uuugaugaua uaaugaaagg ugaagaagga     1380

gggaccuuca aucauccaua uguccuugau gauggaacau cauuggcuug ugcgacgaua     1440

uuuccacauc aguggauaaa ucugagaacc aacaauucag caacaauugu ucuucccugg     1500

augaaugcug cuccaaugga uuucccacuu agacauaauc aguggacgcu agcaauaaua     1560

ccaguggugc cauuagguac gcguacaaca ucaaguaugg ucccaauaac aguuucaauc     1620

gcuccaaugu guugugaguu uaauggacuu agacacgcca uuacucaagg ugucccaaca     1680

uaccuuuuac caggcucggg acaauuccua acaacugaug aucauagcuc ugcaccagcu     1740

cucccguguu ucaacccaac uccagaaaug cauaucccag ggcagguccg uaacaugcua     1800

gaaguggucc aaguggaauc aaugauggag auuaauaaca cagaaagugc aguuggcaug     1860

gagcgucuua agguugauau aucagcauug acagaugucg aucaauuguu auucaacauu     1920

ccacuggaca uacaguugga ugggccacuu agaaacacuu ugguaggaaa cauaucuaga     1980

uauuacacuc auuggucugg aucccuagaa augacguuua uguuuugugg cagcuucaug     2040

gcaacgggaa aauuaauccu gugcuauacu ccuccaggug gaucaugccc gacaaccaga     2100

gagaccgcca uguuagguac acauauuguu ugggauuuug gauuacaauc uaguguaacc     2160

cugauaauac cuuggauuag uggaucccac uacaggaugu uuaauaauga ugcuaaguca     2220

acuaaugcca acguuggcua ugucacuugu uuuaugcaga ccaaucugau aguccccagu     2280

gaauccucug acacguguuc cuugauaggg uucauagcag caaaagauga uuucucccuc     2340

agauuaauga gagacagccc ugacauugga caacuagacc auuuacaugc agcagaggca     2400

gccuaccaga ucgagagcau caucaaaaca gcgaccgaca cugugaaaag ugagauuaau     2460

gcugaacuug gugugguccc uagcuuaaau gcaguugaaa caggugcaac uucuaacacu     2520

gaaccagaag aagccauaca aacucgcaca gugauaaauc agcacggugu auccgagacu     2580

cuaguggaga auuuucucag uagagcagcu uugguaucaa agagaaguuu ugaauacaaa     2640

gaucauacuu cgucugcagc acaagcagac aagaacuuuu ucaaauggac aauuaacacc     2700

agauccuuug uacaguuaag aagaaaauua gaauuauuca cauaccuuag auuugaugcu     2760

gagaucacua uacucacaac uguagcagug aaugguagug guaauaauac auacgugggu     2820

cuuccugacu ugacacucca agcaauguuu guacccacug gugcucuuac cccagaaaaa     2880

caggacucau uccacuggca gucaggcagu aaugcuagug uauucuuuaa aaucuccgac     2940

cccccagcca gaauaaccau accuuuuaug ugcauuaacu cagcauacuc aguuuuuuau     3000

gauggcuuug ccggauuuga gaaaaacggu cuguauggaa uaaauccagc ugacacuauu     3060

gguaacuuau guguuagaau agugaaugaa caccaaccag uugguuucac agugaccguu     3120

aggguuuaca ugaagccuaa acacauaaaa gcaugggcac cacgaccacc acgaacuuug     3180

ccauauauga guauugcaaa ugcaaauuac aaagguaaag aaagagcacc aaaugcgcuc     3240

aaugcuauaa uuggcaauag agacaguguc aaaaccaugc cucauaauau agugaacacu     3300

gguccaggcu ucaugaagca ccugugguuc uuccugcugc ugguggccgc uccuaggugg     3360

gugcuguccc aggugcagcu ggugcagagc ggcguggagg ugaagaagcc cggcgcuucc     3420

gugaaggugu ccugcaaggc cuccggcuac accuucacca acuacuacau guacugggug     3480

aggcaggccc cuggacaggg acuggagugg augggcggca ucaacccuuc caacggcggc     3540

accaacuuca acgagaaguu caagaaccgg gugacccuga ccaccgacuc cuccaccacc     3600

accgccuaca uggagcugaa gucccugcag uuugacgaca ccgccgugua cuacugcgcc     3660

aggagggacu accgguucga caugggcuuc gacuacuggg gccagggcac aaccgugacc     3720

guguccagcg gagguggcgg aucuggaggg ggugguagcg guggaggcgg gagugagauc     3780

gugcugaccc aguccccugc uacacugucc cugucccccg gcgagagggc uacacugagc     3840

ugcagggccu ccaagggcgu guccaccucc ggcuacuccu accugcacug guaccagcag     3900

aagccuggac aggcucccag gcugcugauc uaccuggccu ccuaccugga guccggcgug     3960

ccugcuaggu uuuccggcag cggcagcggc accgauuuca cccugaccau cuccucccug     4020

gagcccgagg acuucgccgu guacuacugc cagcacucca gggaucugcc ucugaccuuc     4080

ggcggcggca ccaaggugga gaucaagagu gucaaaacca ugccucauaa uauagugaac     4140

acugguccag gcuucggagg aguuuuugua gggucuuuca aaauaaucaa cuaucacuug     4200

gccacuacag aagagagaca gucagcuauc uauguggauu ggcaaucaga cgucuugguu     4260

acccccauug cugcucaugg aaggcaccaa auagcaagau gcaagugcaa cacagggguu     4320

uacuauugua ggcacaaaaa cagaaguuac ccgauuugcu uugaaggccc agggauucaa     4380

uggauugaac aaaaugaaua uuacccagca agguaccaga ccaauguacu auuggcaguu     4440

gguccugcgg aagcaggaga uugcgguggu uuacuaguuu guccacaugg gguaaucggu     4500

cuucuuacag caggaggggg uggaauugua gcuuucacug auaucaggaa uuugcuaugg     4560

uuagauacug augcuaugga acaaggcauu acugauuaua uucaaaaucu ugguaaugcc     4620

uuuggagcag gauuuacaga aacaaucucu aauaaagcca aggaagugca agauaugcua     4680

auuggagaga guucacuauu agaaaaauug uuaaaagcuc uaaucaaaau cauaucagca     4740

uuaguaauug uaaucagaaa cucagaagau uuagucacag ucacagccac acuagcauug     4800

uugggaugcc augauucacc auggagcuac uugaaacaga agguauguuc auacuuaggu     4860

auuccuuaug uaccuagaca gggugaaucg uggcuuaaga aauucacaga ggcaugcaau     4920

gcucuuagag gucuggauug gcuaucgcaa aagauagaua aauucaucaa cuggcuuaaa     4980

accaaaauau uaccagaagc uagggagaaa uaugaauuug ugcaaaggcu caaacaguua     5040

ccggugauag aaaaccaagu uaguacaauc gagcauagcu gcccaacaac agaacaacaa     5100

caggccuuau ucaacaacgu ccaauacuau ucacacuacu guagaaagua cgcaccacuu     5160

uacgcagugg aagcaaagag gguaguagcu cuugaaaaga aaauaaacaa cuacauccag     5220

uucaagucca aaucucgcau ugaaccgguu uguuuaauaa uacauggcuc uccaggaacu     5280

ggcaagucag uggcuucaaa uuuaauugcc agggcuauca cagagaaauu ggggggggac     5340

auuuauuccu ugccuccaga cccuaaauau uuugauggau acaaacagca aacagugguc     5400

cucauggaug auuuaaugca aaauccagau gggaaugaca uaucuauguu cugccaaaug     5460

gucuccacug uagauuucau acccccaaug gcuaguuugg aggaaaaagg aacucuauac     5520

accaguccau uuuuaauagc uacuaccaau gcuggcucaa uacaugcacc aacuguauca     5580

gacucaaagg cuuugucacg cagauuuaaa uuugacgugg acauugaagu cacagauuca     5640

uacaaggacu caaauaaauu ggauauguca agggcagucg agaugugcaa accagauggc     5700

ugugccccca ccaauuacaa aagaugcugc ccauugaucu guggaaaggc uauccaauuc     5760

agagaucgca gaacuaaugc aagauccacu auugauaugc uaguaacuga uauuauaaag     5820

gaauauagaa ccagaaacag uacacaggau aagcuggaag cucuguuuca ggggccucca     5880

caguuuaaag agaucaaaau uucagucacc ccagauacac cagcuccuga ugcuauaaau     5940

gaccuucuua ggucagugga uucucaagaa guuagggauu auugccaaaa gaaaggaugg     6000

auuguaguac acccaucaaa ugagcuaaua guagaaaaac acauuaguag agcuuuuauu     6060

acucuacaag ccauugccac cuuuguauca auagcuggug uaguuuaugu uauauacaaa     6120

cuuuuugcug gcauucaggg uccauacaca ggaaucccca auccuaaacc uaaaguaccc     6180

ucucucagaa cagcuaaagu gcaaggacca ggguucgauu uugcacaagc cauaaugaag     6240

aaaaauaccg ucauugcaag gacugaaaag ggugaguuca ccaugcuggg uguauaugau     6300

aggguagcgg ucauccccac acacgcaucu guuggagaaa ccauuuacau uaaugaugua     6360

gagacuaaag uuuuagaugc gugugcacuu agagacuuga cugauacaaa cuuagagaua     6420

accauaguca aauuagaccg uaaucaaaaa uuuagagaua ucagacauuu ucugcccaga     6480

uaugaggaug auuacaauga cgcugugcuu agcguacaua caucaaaauu cccaaauaug     6540

uauaucccag uuggacaagu caccaauuau ggcuucuuga accuaggugg uacaccgacg     6600

caccgcauuu uaauguauaa cuucccaaca agagcuggcc aguguggugg uguggugaca     6660

acuacaggua aggugauagg aauacaugua gguggaaaug gagcucaagg auuugcagca     6720

augcuacuac acucuuacuu uuccgauaca caaggugaga uaguuaguag ugaaaagagu     6780

ggggugugca uuaacgcacc ggcaaagacu aaacuccaac cuaguguuuu ccaucaaguu     6840

uuugaagguu caaaggaacc agcaguucuc aauccaaaag auccuaggcu uaaaacagau     6900

uucgaggagg ccauuuucuc aaaguacaca gguaacaaaa uuauguuaau ggaugaguac     6960

auggaagagg caguggauca uuaugugggg uguuuagaac cauuagacau caguguggau     7020

cccauacccc uggaaagugc cauguaugga auggauggcc uugaggcauu agacuuaacu     7080

accagugcag gauucccuua cuuacuacaa gggaagaaga aaagggauau auuuaauaga     7140

cauacuagag acaccaguga aaugacaaaa auguuagaga aauauggagu ugaccuaccu     7200

uuuguaaccu uuguaaaaga ugagcuuaga ucaagagaaa aaguugaaaa agggaaauca     7260

cgccugauug aggccaguuc cuugaaugac ucaguugcua ugagaguugc cuuuggaaac     7320

cuuuacgcca cauuucacaa caauccaggu acagcaacug guagugcagu ugguugugau     7380

ccagauauau uuuggucaaa aaucccuauu uuguuagaug gagaaaucuu ugcuuuugac     7440

uacacugguu augaugcuag uuugucacca gugugguuug ccugcuuaaa gaaaguucua     7500

auuaaguuag guuacacaca ucaaacgucu uuuauagauu auuuguguca uucaguacau     7560

uuauauaagg acaaaaaaua cauaguuaau gguggaaugc ccucugguuc uucaggcacc     7620

agcauauuca acacuaugau caacaauaua aucauaagaa cuuuauuaau uaggguuuac     7680

aaaggcauag accuggacca guucaaaaug auugccuaug gggaugaugu uauugcuagc     7740

uacccacaua agauugaucc agguuugcug gcagaagcag guaaacagua uggauuagua     7800

augacgccag cagacaaagg aaccaguuuu auugacacaa auugggaaaa uguaacuuuc     7860

uuaaaaagau auuucagagc agaugaucaa uaccccuuuc ucauacaucc agugaugcca     7920

augaaagaga uacaugaauc uauuagaugg acuaaagauc ccagaaacac acaggaucau     7980

guuaggucuu ugugcuaccu cgcauggcau aauggagagg aggcuuauaa ugaauuuugc     8040

agaaaaauca gaagugugcc ugugggaaga gcauugacac uaccugcaua cucuagucuu     8100

agacggaaau gguuagauuc guucuagaca acucuaauug aaacccaagu uauaguuacu     8160

uucauuuaga gguaaauuuu ggucacuugg gggccaaaaa aaaaaaaaaa aaaaaaaaaa     8220

gucgac                                                                8226


<210>  17
<211>  22
<212>  DNA
<213>  人工序列

<220>
<223>  miR-133靶序列的DNA序列

<400>  17
acagctggtt gaaggggacc aa                                                22


<210>  18
<211>  22
<212>  DNA
<213>  人工序列

<220>
<223>  miR-206靶序列的DNA序列

<400>  18
ccacacactt ccttacattc ca                                                22


<210>  19
<211>  102
<212>  DNA
<213>  人工序列

<220>
<223>  miR-133靶序列与miR-206靶序列的串联序列的DNA序列

<400>  19
acagctggtt gaaggggacc aacgatacag ctggttgaag gggaccaaac cggtccacac       60

acttccttac attccatcac ccacacactt ccttacattc ca                         102


<210>  20
<211>  507
<212>  DNA
<213>  人工序列

<220>
<223>  HRV2的内部核糖体进入位点序列的DNA序列

<400>  20
aacttagaag tttttcacaa agaccaatag ccggtaatca gccagattac tgaaggtcaa       60

gcacttctgt ttccccggtc aatgttgata tgctccaaca gggcaaaaac aactgcgatc      120

gttaaccgca aagcgcctac gcaaagctta gtagcatctt tgaaatcgtt tggctggtcg      180

atccgccatt tcccctggta gacctggcag atgaggctag aaatacccca ctggcgacag      240

tgttctagcc tgcgtggctg cctgcacacc ctatgggtgt gaagccaaac aatggacaag      300

gtgtgaagag ccccgtgtgc tcgctttgag tcctccggcc cctgaatgtg gctaacctta      360

accctgcagc tagagcacgt aacccaatgt gtatctagtc gtaatgagca attgcgggat      420

gggaccaact actttgggtg tccgtgtttc actttttcct ttatatttgc ttatggtgac      480

aatatataca atatatatat tggcacc                                          507


