                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Modulating Biomarkers To Increase Tumor Immunity And Improve The 
       Efficacy Of Cancer Immunotherapy

<130>  DFS-185.25

<140>  PCT/US2018/042242
<141>  2017-07-16

<150>  US 62/532,589
<151>  2017-07-14

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  1
acaggctgtt gcgggagcgc gccctcagcg aagcaagtga ggcatctcac tgggaaagtc       60

gaatgtgtgt ggcggccgcc gccgaggcgg gttccgaaga gacctcagca gggcaggcca      120

gggcctacgc gaacgcccac ccttaagagc gcggggacag ggaactggag cgttcctccc      180

agcccccgac gtcgcgggcc cagtgtcccc gtccaggctg gttgggcgca cgcgcggccc      240

cactcgcccc cacgcgtgcg tccccgctgg tcccgccccc ggccggaagt tccggcggcg      300

gagctgggcc gggcccgagc ggatcgcggg ctcgggctgc ggggctccgg ctgcgggcgc      360

tgggccgcga ggcgcggagc ttgggagcgg agcccaggcc gtgccgcgcg gcgccatgaa      420

gggcaaggag gagaaggagg gcggcgcacg gctgggcgct ggcggcggaa gccccgagaa      480

gagcccgagc gcgcaggagc tcaaggagca gggcaatcgt ctgttcgtgg gccgaaagta      540

cccggaggcg gcggcctgct acggccgcgc gatcacccgg aacccgctgg tggccgtgta      600

ttacaccaac cgggccttgt gctacctgaa gatgcagcag cacgagcagg ccctggccga      660

ctgccggcgc gccctggagc tggacgggca gtctgtgaag gcgcacttct tcctggggca      720

gtgccagctg gagatggaga gctatgatga ggccatcgcc aatctgcagc gagcttacag      780

cctggccaag gagcagcggc tgaacttcgg ggacgacatc cccagcgctc ttcgaatcgc      840

gaagaagaag cgctggaaca gcattgagga gcggcgcatc caccaggaga gcgagctgca      900

ctcctacctc tccaggctca ttgccgcgga gcgtgagagg gagctggaag agtgccagcg      960

aaaccacgag ggtgatgagg acgacagcca cgtccgggcc cagcaggcct gcattgaggc     1020

caagcacgac aagtacatgg cggacatgga cgagcttttt tctcaggtgg atgagaagag     1080

gaagaagcga gacatccccg actacctgtg tggcaagatc agctttgagc tgatgcggga     1140

gccgtgcatc acgcccagtg gcatcaccta cgaccgcaag gacatcgagg agcacctgca     1200

gcgtgtgggt cattttgacc ccgtgacccg gagccccctg acccaggaac agctcatccc     1260

caacttggct atgaaggagg ttattgacgc attcatctct gagaatggct gggtggagga     1320

ctactgaggt tccctgccct acctggcgtc ctggtccagg ggagccctgg gcagaagccc     1380

ccggccccta tacatagttt atgttcctgg ccaccccgac cgcttccccc aagttctgct     1440

gttggactct ggactgtttc ccctctcagc atcgcttttg ctgggccgtg atcgtccccc     1500

tttgtgggct ggaaaagcag gtgagggtgg gctgggctga ggccattgcc gccactatct     1560

gtgtaataaa atccgtgagc acgaggtggg acgtgctggt gtgtgaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1650


<210>  2
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Gly Lys Glu Glu Lys Glu Gly Gly Ala Arg Leu Gly Ala Gly 
1               5                   10                  15      


Gly Gly Ser Pro Glu Lys Ser Pro Ser Ala Gln Glu Leu Lys Glu Gln 
            20                  25                  30          


Gly Asn Arg Leu Phe Val Gly Arg Lys Tyr Pro Glu Ala Ala Ala Cys 
        35                  40                  45              


Tyr Gly Arg Ala Ile Thr Arg Asn Pro Leu Val Ala Val Tyr Tyr Thr 
    50                  55                  60                  


Asn Arg Ala Leu Cys Tyr Leu Lys Met Gln Gln His Glu Gln Ala Leu 
65                  70                  75                  80  


Ala Asp Cys Arg Arg Ala Leu Glu Leu Asp Gly Gln Ser Val Lys Ala 
                85                  90                  95      


His Phe Phe Leu Gly Gln Cys Gln Leu Glu Met Glu Ser Tyr Asp Glu 
            100                 105                 110         


Ala Ile Ala Asn Leu Gln Arg Ala Tyr Ser Leu Ala Lys Glu Gln Arg 
        115                 120                 125             


Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys 
    130                 135                 140                 


Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu 
145                 150                 155                 160 


Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu 
                165                 170                 175     


Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His 
            180                 185                 190         


Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met 
        195                 200                 205             


Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys 
    210                 215                 220                 


Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met 
225                 230                 235                 240 


Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp 
                245                 250                 255     


Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg 
            260                 265                 270         


Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu 
        275                 280                 285             


Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
    290                 295                 300             


<210>  3
<211>  1739
<212>  DNA
<213>  Homo sapiens

<400>  3
acaggctgtt gcgggagcgc gccctcagcg aagcaagtga ggcatctcac tgggaaagtc       60

gaatgtgtgt ggcggccgcc gccgaggcgg gttccgaaga gacctcagca gggcaggcca      120

gggcctacgc gaacgcccac ccttaagagc gcggggacag ggaactggag cgttcctccc      180

agcccccgac gtcgcgggcc cagtgtcccc gtccaggctg gttgggcgca cgcgcggccc      240

cactcgcccc cacgcgtgcg tccccgctgg tcccgccccc ggccggaagt tccggcggcg      300

gagctgggcc gggcccgagc ggatcgcggg ctcgggctgc ggggctccgg ctgcgggcgc      360

tgggccgcga ggcgcggagc ttgggagcgg agcccaggcc gtgccgcgcg gcgccatgaa      420

gggcaaggag gagaaggagg gcggcgcacg gctgggcgct ggcggcggaa gccccgagaa      480

gagcccgagc gcgcaggagc tcaaggagca gggcaatcgt ctgttcgtgg gccgaaagta      540

cccggaggcg gcggcctgct acggccgcgc gatcccagag cgcagaagct gggacgggcc      600

gtgggtcaga gtgggcacgc tgagcctacg ccctcatgcg gctggcccgg ccttggtccc      660

tagacccgga acccgctggt ggccgtgtat tacaccaacc gggccttgtg ctacctgaag      720

atgcagcagc acgagcaggc cctggccgac tgccggcgcg ccctggagct ggacgggcag      780

tctgtgaagg cgcacttctt cctggggcag tgccagctgg agatggagag ctatgatgag      840

gccatcgcca atctgcagcg agcttacagc ctggccaagg agcagcggct gaacttcggg      900

gacgacatcc ccagcgctct tcgaatcgcg aagaagaagc gctggaacag cattgaggag      960

cggcgcatcc accaggagag cgagctgcac tcctacctct ccaggctcat tgccgcggag     1020

cgtgagaggg agctggaaga gtgccagcga aaccacgagg gtgatgagga cgacagccac     1080

gtccgggccc agcaggcctg cattgaggcc aagcacgaca agtacatggc ggacatggac     1140

gagctttttt ctcaggtgga tgagaagagg aagaagcgag acatccccga ctacctgtgt     1200

ggcaagatca gctttgagct gatgcgggag ccgtgcatca cgcccagtgg catcacctac     1260

gaccgcaagg acatcgagga gcacctgcag cgtgtgggtc attttgaccc cgtgacccgg     1320

agccccctga cccaggaaca gctcatcccc aacttggcta tgaaggaggt tattgacgca     1380

ttcatctctg agaatggctg ggtggaggac tactgaggtt ccctgcccta cctggcgtcc     1440

tggtccaggg gagccctggg cagaagcccc cggcccctat acatagttta tgttcctggc     1500

caccccgacc gcttccccca agttctgctg ttggactctg gactgtttcc cctctcagca     1560

tcgcttttgc tgggccgtga tcgtccccct ttgtgggctg gaaaagcagg tgagggtggg     1620

ctgggctgag gccattgccg ccactatctg tgtaataaaa tccgtgagca cgaggtggga     1680

cgtgctggtg tgtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1739


<210>  4
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Gln His Glu Gln Ala Leu Ala Asp Cys Arg Arg Ala Leu Glu 
1               5                   10                  15      


Leu Asp Gly Gln Ser Val Lys Ala His Phe Phe Leu Gly Gln Cys Gln 
            20                  25                  30          


Leu Glu Met Glu Ser Tyr Asp Glu Ala Ile Ala Asn Leu Gln Arg Ala 
        35                  40                  45              


Tyr Ser Leu Ala Lys Glu Gln Arg Leu Asn Phe Gly Asp Asp Ile Pro 
    50                  55                  60                  


Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu 
65                  70                  75                  80  


Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg Leu 
                85                  90                  95      


Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn His 
            100                 105                 110         


Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys Ile 
        115                 120                 125             


Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe Ser 
    130                 135                 140                 


Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys 
145                 150                 155                 160 


Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro Ser 
                165                 170                 175     


Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg Val 
            180                 185                 190         


Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu 
        195                 200                 205             


Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser Glu 
    210                 215                 220                 


Asn Gly Trp Val Glu Asp Tyr 
225                 230     


<210>  5
<211>  1672
<212>  DNA
<213>  Mus musculus

<400>  5
ggccgcaggc agctcctccc gattcccgag gaagcccctc gagagcggtc tgatctgcgg       60

gcctctcttc taccctcaat tccgccttcc taccggcggt ccagacgttc ccaggctgtc      120

gcgtgagccc gtgtgtgccc tggtggtgcg ctaggacccg ggcctagtga ccggccctcg      180

gaaggccact tctcaatgac cgctgccacg ttcgcccagc ttggggccgg agggcggggc      240

ttgagcgccg atgggcggag ccttggtctg agcagggtag gtctcggtta ctgtagggcg      300

gggcctgtag agcgcggcgg aagcttctca gagctaaggg aactggctca atccacgagg      360

ctccgccttt gctcacgtgt ccccatgcca gctccgcccc acaccggaag ttccggtggc      420

ggatcgccga ccgggcggag ctgatcgctg cgcgggctgc gagatctagg tggccgggcg      480

cggagcccaa gccgtgccgc gcggcgccat gaagggcaag gaggaaaagg agggcggcgc      540

gcggctgggc actggtggcg gcggcagccc tgataagagc ccgagtgcgc aagagctcaa      600

ggagcaggga aaccggctct tcgtgggccg caagtacccg gaggcggcgg cctgctacgg      660

ccgcgccatc actcggaacc cacttgtggc agtgtactac actaaccggg ccctgtgcta      720

tctgaagatg cagcagcctg aacaggcact tgctgactgc cggcgagccc tggagctgga      780

cgggcagtct gtgaaggcgc acttcttcct ggggcagtgc cagctggaga tggagagtta      840

tgatgaggcc attgccaatc tgcagcgagc ctatagtttg gccaaggagc agcgactcaa      900

ctttggggat gatattccta gtgcccttcg cattgctaag aagaagcgct ggaacagtat      960

cgaggaacgg cgcatccacc aggagagtga gctgcattca tatctcacca ggctcattgc     1020

tgctgagcga gagagggaac tggaggagtg tcagcggaac cacgagggtc atgaagatga     1080

tggccacatc cgggcccagc aggcctgcat tgaggccaag cacgataaat acatggcaga     1140

tatggatgag ctcttctctc aggtggacga gaaaagaaag aagcgagata tccctgacta     1200

cttgtgtggc aagattagct ttgagctgat gcgggaaccc tgcattacac ccagtggtat     1260

cacctatgac cgcaaggaca ttgaggagca cctgcagcgt gtgggccact ttgaccctgt     1320

gacccggagc cctctgaccc aggaacagct catccccaac ttggccatga aggaagtcat     1380

tgacgctttc atctctgaga acggctgggt agaggactat tgaggcccca tgtcctgcct     1440

ggcaccctgg cccaggagga tctggagacg gaagctccag tccctgtata gtttgtgtcc     1500

ctgggcctgc ccccatcggc cctgctgatg ggttctgaac tgctcccctt ctcagcatac     1560

cccttgctgg accatgagcc tcccttgtcc cccttctggg ctggagagtg ggtgagggtg     1620

ggctgaggtt gctgctgctg ccactgtcct gtaataaagt ctgtgagcac ta             1672


<210>  6
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  6

Met Lys Gly Lys Glu Glu Lys Glu Gly Gly Ala Arg Leu Gly Thr Gly 
1               5                   10                  15      


Gly Gly Gly Ser Pro Asp Lys Ser Pro Ser Ala Gln Glu Leu Lys Glu 
            20                  25                  30          


Gln Gly Asn Arg Leu Phe Val Gly Arg Lys Tyr Pro Glu Ala Ala Ala 
        35                  40                  45              


Cys Tyr Gly Arg Ala Ile Thr Arg Asn Pro Leu Val Ala Val Tyr Tyr 
    50                  55                  60                  


Thr Asn Arg Ala Leu Cys Tyr Leu Lys Met Gln Gln Pro Glu Gln Ala 
65                  70                  75                  80  


Leu Ala Asp Cys Arg Arg Ala Leu Glu Leu Asp Gly Gln Ser Val Lys 
                85                  90                  95      


Ala His Phe Phe Leu Gly Gln Cys Gln Leu Glu Met Glu Ser Tyr Asp 
            100                 105                 110         


Glu Ala Ile Ala Asn Leu Gln Arg Ala Tyr Ser Leu Ala Lys Glu Gln 
        115                 120                 125             


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
    130                 135                 140                 


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
145                 150                 155                 160 


Glu Leu His Ser Tyr Leu Thr Arg Leu Ile Ala Ala Glu Arg Glu Arg 
                165                 170                 175     


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly His Glu Asp Asp Gly 
            180                 185                 190         


His Ile Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
        195                 200                 205             


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
    210                 215                 220                 


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
225                 230                 235                 240 


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
                245                 250                 255     


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
            260                 265                 270         


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
        275                 280                 285             


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
    290                 295                 300                 


<210>  7
<211>  4177
<212>  DNA
<213>  Homo sapiens

<400>  7
aatttcgcta accgtgacgt catctcggtg cgccgttaca gcgcttaact ggaaactgcg       60

atttagtttt tggtgaaagg agtggaaaaa aaccatgaac tgacctaccc cgccccattt      120

tgcttttagt ccttcacact ggcttcgcct gcactttggg caatggagcg ggaaaggaaa      180

aggcacgcag gctgagctca aagtcgcgcc agccggggat gactcggcga cgccgccagg      240

cgcgttaccc ggcgtgctcc gcgcggcgcc ggcgaaggga cgtgggggaa ggggcaggga      300

ggaggaagcg gtggctgctg cggatgtcgg tgtgagcgag cggcgcctga acacacggcg      360

gctgccgagc gcctgacccg ggcctgcgcc agagcctgca ccgagctccg gggccccaca      420

cccgctacgg tggccctgcg cccgttgcta ctgaggcggc gtgctctgca ttcttcgctg      480

tccaggcctg ccggctctgg tgtctgctgg ctcctccttg ctcgcctgct ccctcctgct      540

tgcctgagtc accgccgccg ccgccgccac agccatggcc gagagtggtg aaagcggcgg      600

tcctccgggc tcccaggata gcgccgccgg agccgaaggt gctggcgccc ccgcggccgc      660

tgcctccgcg gagcccaaaa tcatgaaagt caccgtgaag accccgaagg aaaaggagga      720

attcgccgtg cccgagaata gctccgtcca gcagtttaag gaagaaatct ctaaacgttt      780

taaatcacat actgaccaac ttgtgttgat atttgctgga aaaattttga aagatcaaga      840

taccttgagt cagcatggaa ttcatgatgg acttactgtt caccttgtca ttaaaacaca      900

aaacaggcct caggatcatt cagctcagca aacaaataca gctggaagca atgttactac      960

atcatcaact cctaatagta actctacatc tggttctgct actagcaacc cttttggttt     1020

aggtggcctt gggggacttg caggtctgag tagcttgggt ttgaatacta ccaacttctc     1080

tgaactacag agtcagatgc agcgacaact tttgtctaac cctgaaatga tggtccagat     1140

catggaaaat ccctttgttc agagcatgct ctcaaatcct gacctgatga gacagttaat     1200

tatggccaat ccacaaatgc agcagttgat acagagaaat ccagaaatta gtcatatgtt     1260

gaataatcca gatataatga gacaaacgtt ggaacttgcc aggaatccag caatgatgca     1320

ggagatgatg aggaaccagg accgagcttt gagcaaccta gaaagcatcc cagggggata     1380

taatgcttta aggcgcatgt acacagatat tcaggaacca atgctgagtg ctgcacaaga     1440

gcagtttggt ggtaatccat ttgcttcctt ggtgagcaat acatcctctg gtgaaggtag     1500

tcaaccttcc cgtacagaaa atagagatcc actacccaat ccatgggctc cacagacttc     1560

ccagagttca tcagcttcca gcggcactgc cagcactgtg ggtggcacta ctggtagtac     1620

tgccagtggc acttctgggc agagtactac tgcgccaaat ttggtgcctg gagtaggagc     1680

tagtatgttc aacacaccag gaatgcagag cttgttgcaa caaataactg aaaacccaca     1740

actgatgcaa aacatgttgt ctgcccccta catgagaagc atgatgcagt cactaagcca     1800

gaatcctgac cttgctgcac agatgatgct gaataatccc ctatttgctg gaaatcctca     1860

gcttcaagaa caaatgagac aacagctccc aactttcctc caacaaatgc agaatcctga     1920

tacactatca gcaatgtcaa accctagagc aatgcaggcc ttgttacaga ttcagcaggg     1980

tttacagaca ttagcaacgg aagccccggg cctcatccca gggtttactc ctggcttggg     2040

ggcattagga agcactggag gctcttcggg aactaatgga tctaacgcca cacctagtga     2100

aaacacaagt cccacagcag gaaccactga acctggacat cagcagttta ttcagcagat     2160

gctgcaggct cttgctggag taaatcctca gctacagaat ccagaagtca gatttcagca     2220

acaactggaa caactcagtg caatgggatt tttgaaccgt gaagcaaact tgcaagctct     2280

aatagcaaca ggaggtgata tcaatgcagc tattgaaagg ttactgggct cccagccatc     2340

atagcagcat ttctgtatct tgaaaaaatg taatttattt ttgataacgg ctcttaaact     2400

ttaaaatacc tgctttattt cattttgact cttggaattc tgtgctgtta taaacaaacc     2460

caatatgatg cattttaagg tggagtacag taagatgtgt gggtttttct gtatttttct     2520

tttctggaac agtgggaatt aaggctactg catgcatcac ttctgcattt attgtaattt     2580

tttaaaaaca tcacctttta tagttgggtg accagatttt gtcctgcatc tgtccagttt     2640

atttgctttt taaacattag cctatggtag taatttatgt agaataaaag cattaaaaag     2700

aagcaaatca tttgcactct ataatttgtg gtacagtatt gcttattgtg actttggcat     2760

gcatttttgc aaacaatgct gtaagattta tactactgat aattttgttt tatttgtata     2820

caatatagag tatgcacatt tgggactgca tttctggaaa catactgcaa taggctctct     2880

gagcaaaaca cctgtaacta aaaaagtgaa gataagaaaa tactcttaaa gctgagtatt     2940

tcctaattgt atagaatctt acagcatctt tgacaaacat ctcccagcaa aagtgccggt     3000

tagtcaggtt tgttgaaaat acagtagaaa agctgattct ggttatctct ttaaggacaa     3060

ttaattgtac agacacataa tgtaacattg tctcaacatt cattcacaga ttgactgtaa     3120

attaccttaa tctttgtgca gactgaagga acactgtagt ataccccaaa gtgcatttgc     3180

ctaggacttc tcagcttctc ccataggtag tttaacaggc attaaaattt gtaattgaaa     3240

tgttgctttc actgaaaaag tgtcttgatg tttcagttat ttttaatcgc cataaaaaaa     3300

tagaactatc ttttgggttt atctgttttc tcatgcacag gcaatacaca aatttaaaat     3360

gagttgtgag ccaattgttt ctgaagtgtt ttggtagttc tattaagaaa tagttaaata     3420

ttgtgctttt cagagcctca gagaaagggg gacggggtgg gggggtgggg cagcggaatc     3480

tgtcctggat ggggccagct taaataatac tggcaaccaa gattctgtta ggatttctgt     3540

gcatatagtg tagtaaagaa gtatcattca ggggtgaaaa acaaagagcc gttttaatga     3600

tgttgagtac atttggctgt tttatagcct ttttcttccc tcccccaaag aattctgttt     3660

gcctaactcc caaactgttg gggtggtaca ttcctttagg accaattaaa acataattga     3720

gggtcagtga tacatttggc tgactctggt tcagtattct cttaggtgat tatattctct     3780

catgtacagt tacaggaaat taaaatgtta aagtaaccta aaatgaattc agaccaataa     3840

aatcaaggga aatacaagtt gattgcatta cttctgtatg ttgcttgcta ttaaaaaggt     3900

taagaggcca ggttacccac cagtccttgc actgttctga cactttcccc aggaggaaaa     3960

caagtacaaa ggttacggtg gaggcataag tagaagagat tgttaagaag ggtattcatg     4020

tgtctttgct ctttctgctt tatgcctcag tttggtttaa aaacttctgt actggcaaat     4080

ggtggtattc agtgtgggat agtgtcataa ctaatttgac aatttattaa tcataaaata     4140

acaataaatc tctagctttt acacttgaaa aaaaaaa                              4177


<210>  8
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Ser Gly Glu Ser Gly Gly Pro Pro Gly Ser Gln Asp Ser 
1               5                   10                  15      


Ala Ala Gly Ala Glu Gly Ala Gly Ala Pro Ala Ala Ala Ala Ser Ala 
            20                  25                  30          


Glu Pro Lys Ile Met Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu 
        35                  40                  45              


Glu Phe Ala Val Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Glu 
    50                  55                  60                  


Ile Ser Lys Arg Phe Lys Ser His Thr Asp Gln Leu Val Leu Ile Phe 
65                  70                  75                  80  


Ala Gly Lys Ile Leu Lys Asp Gln Asp Thr Leu Ser Gln His Gly Ile 
                85                  90                  95      


His Asp Gly Leu Thr Val His Leu Val Ile Lys Thr Gln Asn Arg Pro 
            100                 105                 110         


Gln Asp His Ser Ala Gln Gln Thr Asn Thr Ala Gly Ser Asn Val Thr 
        115                 120                 125             


Thr Ser Ser Thr Pro Asn Ser Asn Ser Thr Ser Gly Ser Ala Thr Ser 
    130                 135                 140                 


Asn Pro Phe Gly Leu Gly Gly Leu Gly Gly Leu Ala Gly Leu Ser Ser 
145                 150                 155                 160 


Leu Gly Leu Asn Thr Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln 
                165                 170                 175     


Arg Gln Leu Leu Ser Asn Pro Glu Met Met Val Gln Ile Met Glu Asn 
            180                 185                 190         


Pro Phe Val Gln Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu 
        195                 200                 205             


Ile Met Ala Asn Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu 
    210                 215                 220                 


Ile Ser His Met Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu 
225                 230                 235                 240 


Leu Ala Arg Asn Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp 
                245                 250                 255     


Arg Ala Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu 
            260                 265                 270         


Arg Arg Met Tyr Thr Asp Ile Gln Glu Pro Met Leu Ser Ala Ala Gln 
        275                 280                 285             


Glu Gln Phe Gly Gly Asn Pro Phe Ala Ser Leu Val Ser Asn Thr Ser 
    290                 295                 300                 


Ser Gly Glu Gly Ser Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu 
305                 310                 315                 320 


Pro Asn Pro Trp Ala Pro Gln Thr Ser Gln Ser Ser Ser Ala Ser Ser 
                325                 330                 335     


Gly Thr Ala Ser Thr Val Gly Gly Thr Thr Gly Ser Thr Ala Ser Gly 
            340                 345                 350         


Thr Ser Gly Gln Ser Thr Thr Ala Pro Asn Leu Val Pro Gly Val Gly 
        355                 360                 365             


Ala Ser Met Phe Asn Thr Pro Gly Met Gln Ser Leu Leu Gln Gln Ile 
    370                 375                 380                 


Thr Glu Asn Pro Gln Leu Met Gln Asn Met Leu Ser Ala Pro Tyr Met 
385                 390                 395                 400 


Arg Ser Met Met Gln Ser Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln 
                405                 410                 415     


Met Met Leu Asn Asn Pro Leu Phe Ala Gly Asn Pro Gln Leu Gln Glu 
            420                 425                 430         


Gln Met Arg Gln Gln Leu Pro Thr Phe Leu Gln Gln Met Gln Asn Pro 
        435                 440                 445             


Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Ala Leu Leu 
    450                 455                 460                 


Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu 
465                 470                 475                 480 


Ile Pro Gly Phe Thr Pro Gly Leu Gly Ala Leu Gly Ser Thr Gly Gly 
                485                 490                 495     


Ser Ser Gly Thr Asn Gly Ser Asn Ala Thr Pro Ser Glu Asn Thr Ser 
            500                 505                 510         


Pro Thr Ala Gly Thr Thr Glu Pro Gly His Gln Gln Phe Ile Gln Gln 
        515                 520                 525             


Met Leu Gln Ala Leu Ala Gly Val Asn Pro Gln Leu Gln Asn Pro Glu 
    530                 535                 540                 


Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Ser Ala Met Gly Phe Leu 
545                 550                 555                 560 


Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly Gly Asp Ile 
                565                 570                 575     


Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
            580                 585                 


<210>  9
<211>  4093
<212>  DNA
<213>  Homo sapiens

<400>  9
aatttcgcta accgtgacgt catctcggtg cgccgttaca gcgcttaact ggaaactgcg       60

atttagtttt tggtgaaagg agtggaaaaa aaccatgaac tgacctaccc cgccccattt      120

tgcttttagt ccttcacact ggcttcgcct gcactttggg caatggagcg ggaaaggaaa      180

aggcacgcag gctgagctca aagtcgcgcc agccggggat gactcggcga cgccgccagg      240

cgcgttaccc ggcgtgctcc gcgcggcgcc ggcgaaggga cgtgggggaa ggggcaggga      300

ggaggaagcg gtggctgctg cggatgtcgg tgtgagcgag cggcgcctga acacacggcg      360

gctgccgagc gcctgacccg ggcctgcgcc agagcctgca ccgagctccg gggccccaca      420

cccgctacgg tggccctgcg cccgttgcta ctgaggcggc gtgctctgca ttcttcgctg      480

tccaggcctg ccggctctgg tgtctgctgg ctcctccttg ctcgcctgct ccctcctgct      540

tgcctgagtc accgccgccg ccgccgccac agccatggcc gagagtggtg aaagcggcgg      600

tcctccgggc tcccaggata gcgccgccgg agccgaaggt gctggcgccc ccgcggccgc      660

tgcctccgcg gagcccaaaa tcatgaaagt caccgtgaag accccgaagg aaaaggagga      720

attcgccgtg cccgagaata gctccgtcca gcagtttaag gaagaaatct ctaaacgttt      780

taaatcacat actgaccaac ttgtgttgat atttgctgga aaaattttga aagatcaaga      840

taccttgagt cagcatggaa ttcatgatgg acttactgtt caccttgtca ttaaaacaca      900

aaacaggcct caggatcatt cagctcagca aacaaataca gctggaagca atgttactac      960

atcatcaact cctaatagta actctacatc tggttctgct actagcaacc cttttggttt     1020

aggtggcctt gggggacttg caggtctgag tagcttgggt ttgaatacta ccaacttctc     1080

tgaactacag agtcagatgc agcgacaact tttgtctaac cctgaaatga tggtccagat     1140

catggaaaat ccctttgttc agagcatgct ctcaaatcct gacctgatga gacagttaat     1200

tatggccaat ccacaaatgc agcagttgat acagagaaat ccagaaatta gtcatatgtt     1260

gaataatcca gatataatga gacaaacgtt ggaacttgcc aggaatccag caatgatgca     1320

ggagatgatg aggaaccagg accgagcttt gagcaaccta gaaagcatcc cagggggata     1380

taatgcttta aggcgcatgt acacagatat tcaggaacca atgctgagtg ctgcacaaga     1440

gcagtttggt ggtaatccat ttgcttcctt ggtgagcaat acatcctctg gtgaaggtag     1500

tcaaccttcc cgtacagaaa atagagatcc actacccaat ccatgggctc cacagacttc     1560

ccagagttca tcagcttcca gcggcactgc cagcactgtg ggtggcacta ctggtagtac     1620

tgccagtggc acttctgggc agagtactac tgcgccaaat ttggtgcctg gagtaggagc     1680

tagtatgttc aacacaccag gaatgcagag cttgttgcaa caaataactg aaaacccaca     1740

actgatgcaa aacatgttgt ctgcccccta catgagaagc atgatgcagt cactaagcca     1800

gaatcctgac cttgctgcac agatgcagaa tcctgataca ctatcagcaa tgtcaaaccc     1860

tagagcaatg caggccttgt tacagattca gcagggttta cagacattag caacggaagc     1920

cccgggcctc atcccagggt ttactcctgg cttgggggca ttaggaagca ctggaggctc     1980

ttcgggaact aatggatcta acgccacacc tagtgaaaac acaagtccca cagcaggaac     2040

cactgaacct ggacatcagc agtttattca gcagatgctg caggctcttg ctggagtaaa     2100

tcctcagcta cagaatccag aagtcagatt tcagcaacaa ctggaacaac tcagtgcaat     2160

gggatttttg aaccgtgaag caaacttgca agctctaata gcaacaggag gtgatatcaa     2220

tgcagctatt gaaaggttac tgggctccca gccatcatag cagcatttct gtatcttgaa     2280

aaaatgtaat ttatttttga taacggctct taaactttaa aatacctgct ttatttcatt     2340

ttgactcttg gaattctgtg ctgttataaa caaacccaat atgatgcatt ttaaggtgga     2400

gtacagtaag atgtgtgggt ttttctgtat ttttcttttc tggaacagtg ggaattaagg     2460

ctactgcatg catcacttct gcatttattg taatttttta aaaacatcac cttttatagt     2520

tgggtgacca gattttgtcc tgcatctgtc cagtttattt gctttttaaa cattagccta     2580

tggtagtaat ttatgtagaa taaaagcatt aaaaagaagc aaatcatttg cactctataa     2640

tttgtggtac agtattgctt attgtgactt tggcatgcat ttttgcaaac aatgctgtaa     2700

gatttatact actgataatt ttgttttatt tgtatacaat atagagtatg cacatttggg     2760

actgcatttc tggaaacata ctgcaatagg ctctctgagc aaaacacctg taactaaaaa     2820

agtgaagata agaaaatact cttaaagctg agtatttcct aattgtatag aatcttacag     2880

catctttgac aaacatctcc cagcaaaagt gccggttagt caggtttgtt gaaaatacag     2940

tagaaaagct gattctggtt atctctttaa ggacaattaa ttgtacagac acataatgta     3000

acattgtctc aacattcatt cacagattga ctgtaaatta ccttaatctt tgtgcagact     3060

gaaggaacac tgtagtatac cccaaagtgc atttgcctag gacttctcag cttctcccat     3120

aggtagttta acaggcatta aaatttgtaa ttgaaatgtt gctttcactg aaaaagtgtc     3180

ttgatgtttc agttattttt aatcgccata aaaaaataga actatctttt gggtttatct     3240

gttttctcat gcacaggcaa tacacaaatt taaaatgagt tgtgagccaa ttgtttctga     3300

agtgttttgg tagttctatt aagaaatagt taaatattgt gcttttcaga gcctcagaga     3360

aagggggacg gggtgggggg gtggggcagc ggaatctgtc ctggatgggg ccagcttaaa     3420

taatactggc aaccaagatt ctgttaggat ttctgtgcat atagtgtagt aaagaagtat     3480

cattcagggg tgaaaaacaa agagccgttt taatgatgtt gagtacattt ggctgtttta     3540

tagccttttt cttccctccc ccaaagaatt ctgtttgcct aactcccaaa ctgttggggt     3600

ggtacattcc tttaggacca attaaaacat aattgagggt cagtgataca tttggctgac     3660

tctggttcag tattctctta ggtgattata ttctctcatg tacagttaca ggaaattaaa     3720

atgttaaagt aacctaaaat gaattcagac caataaaatc aagggaaata caagttgatt     3780

gcattacttc tgtatgttgc ttgctattaa aaaggttaag aggccaggtt acccaccagt     3840

ccttgcactg ttctgacact ttccccagga ggaaaacaag tacaaaggtt acggtggagg     3900

cataagtaga agagattgtt aagaagggta ttcatgtgtc tttgctcttt ctgctttatg     3960

cctcagtttg gtttaaaaac ttctgtactg gcaaatggtg gtattcagtg tgggatagtg     4020

tcataactaa tttgacaatt tattaatcat aaaataacaa taaatctcta gcttttacac     4080

ttgaaaaaaa aaa                                                        4093


<210>  10
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Ser Gly Glu Ser Gly Gly Pro Pro Gly Ser Gln Asp Ser 
1               5                   10                  15      


Ala Ala Gly Ala Glu Gly Ala Gly Ala Pro Ala Ala Ala Ala Ser Ala 
            20                  25                  30          


Glu Pro Lys Ile Met Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu 
        35                  40                  45              


Glu Phe Ala Val Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Glu 
    50                  55                  60                  


Ile Ser Lys Arg Phe Lys Ser His Thr Asp Gln Leu Val Leu Ile Phe 
65                  70                  75                  80  


Ala Gly Lys Ile Leu Lys Asp Gln Asp Thr Leu Ser Gln His Gly Ile 
                85                  90                  95      


His Asp Gly Leu Thr Val His Leu Val Ile Lys Thr Gln Asn Arg Pro 
            100                 105                 110         


Gln Asp His Ser Ala Gln Gln Thr Asn Thr Ala Gly Ser Asn Val Thr 
        115                 120                 125             


Thr Ser Ser Thr Pro Asn Ser Asn Ser Thr Ser Gly Ser Ala Thr Ser 
    130                 135                 140                 


Asn Pro Phe Gly Leu Gly Gly Leu Gly Gly Leu Ala Gly Leu Ser Ser 
145                 150                 155                 160 


Leu Gly Leu Asn Thr Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln 
                165                 170                 175     


Arg Gln Leu Leu Ser Asn Pro Glu Met Met Val Gln Ile Met Glu Asn 
            180                 185                 190         


Pro Phe Val Gln Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu 
        195                 200                 205             


Ile Met Ala Asn Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu 
    210                 215                 220                 


Ile Ser His Met Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu 
225                 230                 235                 240 


Leu Ala Arg Asn Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp 
                245                 250                 255     


Arg Ala Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu 
            260                 265                 270         


Arg Arg Met Tyr Thr Asp Ile Gln Glu Pro Met Leu Ser Ala Ala Gln 
        275                 280                 285             


Glu Gln Phe Gly Gly Asn Pro Phe Ala Ser Leu Val Ser Asn Thr Ser 
    290                 295                 300                 


Ser Gly Glu Gly Ser Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu 
305                 310                 315                 320 


Pro Asn Pro Trp Ala Pro Gln Thr Ser Gln Ser Ser Ser Ala Ser Ser 
                325                 330                 335     


Gly Thr Ala Ser Thr Val Gly Gly Thr Thr Gly Ser Thr Ala Ser Gly 
            340                 345                 350         


Thr Ser Gly Gln Ser Thr Thr Ala Pro Asn Leu Val Pro Gly Val Gly 
        355                 360                 365             


Ala Ser Met Phe Asn Thr Pro Gly Met Gln Ser Leu Leu Gln Gln Ile 
    370                 375                 380                 


Thr Glu Asn Pro Gln Leu Met Gln Asn Met Leu Ser Ala Pro Tyr Met 
385                 390                 395                 400 


Arg Ser Met Met Gln Ser Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln 
                405                 410                 415     


Met Gln Asn Pro Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met 
            420                 425                 430         


Gln Ala Leu Leu Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu 
        435                 440                 445             


Ala Pro Gly Leu Ile Pro Gly Phe Thr Pro Gly Leu Gly Ala Leu Gly 
    450                 455                 460                 


Ser Thr Gly Gly Ser Ser Gly Thr Asn Gly Ser Asn Ala Thr Pro Ser 
465                 470                 475                 480 


Glu Asn Thr Ser Pro Thr Ala Gly Thr Thr Glu Pro Gly His Gln Gln 
                485                 490                 495     


Phe Ile Gln Gln Met Leu Gln Ala Leu Ala Gly Val Asn Pro Gln Leu 
            500                 505                 510         


Gln Asn Pro Glu Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Ser Ala 
        515                 520                 525             


Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr 
    530                 535                 540                 


Gly Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro 
545                 550                 555                 560 


Ser 
    


<210>  11
<211>  3693
<212>  DNA
<213>  Mus musculus

<400>  11
agagtgccct gcgcggcgcc ggcgacgagc gtgggggagg tgcgggagga ggaagcggcg       60

gcgacgcgga gagtccccgc gtccacacgg cagccgatcg cccacccggg gcctgcaccc      120

gcagcccgcg tccacgcacc ctcggcggcc ccgcagcctg tcacgcctcg cggacccggc      180

cgcagcccgc agtgtcgcgc tcgcctgagt caccgccatg gccgagagcg cagagagcgg      240

cggcccaccg ggcgcgcagg acagtgcggc cgacggcggc cccgcagagc ccaagatcat      300

gaaggtcacg gtgaagacgc ctaaagagaa ggaggagttt gccgtgcccg agaacagctc      360

ggtccagcag ttcaaagagg aaatctctaa acgtttcaaa tctcatattg accaacttgt      420

gttgatattt gctggaaaaa ttttaaaaga tcaagatact ctgagtcagc atgggattca      480

tgatggactt acggttcacc ttgtcatcaa aacacagaac aggccgcaag ataattcagc      540

tcagcaaaca aatgcccctg gaagcactgt gaccagctca ccagctcccg atagcaaccc      600

cacgtctggt tctgctgcta acagctcctt tggcgtaggc ggacttggag gacttgcagg      660

tcttagcagc ttgggtttaa acaccaccaa cttctctgaa ctccagagcc aaatgcagcg      720

gcaacttttg tctaaccctg aaatgatggt ccagatcatg gaaaatccct ttgtccagag      780

catgctctca aatcctgacc tgatgcggca attgattatg gccaatccac agatgcaaca      840

gttgatacag agaaatccag agattagtca tatgcttaat aatccagata taatgagaca      900

aacactggaa cttgcgagaa atccagcgat gatgcaggaa atgatgagaa accaggaccg      960

agccttgagc aacctagaaa gtattcctgg gggctataat gccttacggc gcatgtacac     1020

cgatatccag gagcctatgc tgaatgctgc tcaagaacag tttggtggta atccatttgc     1080

gtccttagtg agcagttcgt cctcagcaga agggactcag ccttctcgaa cagaaaatag     1140

ggatccgctc cccaacccgt gggctccgca gacttcccag agctcaccag cctccggtac     1200

cactggcagc accactaaca ccatgagcac ctctggtggc actgccacca gtacccctgc     1260

tggacagagc acctcgggcc caagcttggt gcctggcgca ggagctagta tgttcaacac     1320

ccccggaatg cagagcctgc tgcagcagat aactgagaac ccacagctca tgcagaacat     1380

gctgtccgcc ccatacatga ggagcatgct gcagtccctg agccagaacc ccgaccttgc     1440

tgcgcagatg atgctgaata atcccctatt tgctggaaat cctcagcttc aagaacaaat     1500

gagacaacag ctcccaactt tcctccaaca aatgcagaac cccgacacgc tctcagcgat     1560

gtcgaatcct agagccatgc aggcgctgct gcagatccag cagggcttgc agacgctggc     1620

cacagaagct cctggcctca tcccagggtt tactcctggc ttggcagcag gcaattctgg     1680

aggctcttcc ggaaccaatg cacctagcac tgcacctagt gaagatacga acccccaagg     1740

gggcactgct gagccaggcc accagcagtt tatccagcag atgctgcagg cccttgcggg     1800

ggtgaatcct cagctgcaga gtccagaagt cagatttcag caacaactgg aacaactcag     1860

tgccatggga ttcttgaacc gtgaagcaaa cctgcaagct ctgatagcca cagggggcga     1920

catcaatgca gcaatcgaaa ggttgctggg ctcccagccg tcatagcagc atctctctat     1980

cctgagaaaa tgtaatttat ttttgataac ggctcttaaa tctttaaaat aacatgcttt     2040

atttcattgg gattctgtgc tgttataaag gaaaccaata ggaagtatct ggaggcagag     2100

tgcagtacga cgggcgggtt tctgtgtctt tttggaacag tgggaatcaa tgtttcttct     2160

ggttaaggct gctgcatgca tcaaacactt ggcatttatt gtaattttta aaaaaatatc     2220

accttttcta attgggtgaa caaatttttg tcctgcatct gtccaactaa cttgcttttt     2280

aaacataacc ctatggtagt aatttatgta gaataaaggc attaaaaagc agatcatttg     2340

cgcgccccat gatttctggt acaatagtgc ttgttgtgac tttggcatgc actttgcaaa     2400

tgatgctgta agatttatac tcctgacaat tttgtttatt tgtatacaat acaaattatt     2460

gcacatttct aggccatcta agcaaaattt ctgtaactaa aaaagtacaa taaggattcc     2520

taattgtgta gaatcttaca gcatctttga taaacatctc agcagaagtg ccatttagtc     2580

tgtgtggaaa ataaagaaaa actaactctg gttatctctt tagggacatt taattgtaca     2640

gacaacataa tgtaacaata tctcagcatt atataatggc tgtaaattac ctttccttgt     2700

gccgactgga ggagcactgt atcatgctct gatgtgtttg ctggggcgtc ctgctccccg     2760

taggtgtcgt ctacgcagca ttgagtttat tgaaatgtcg ctttcactgg aagtgcggat     2820

gtttcggttc taattgccat ataaaagtag agctgtctct tgggtttatc agctttctca     2880

ttcataggca atacctcgat tttaaatgat tagtgagcca cttgtttctc aagtgtttgg     2940

ctagttctat taagaaatag ttgaatgtcg tgctgttcgg agcctcagaa gggggtgggg     3000

gaggggtgaa acagaatcta ttctggattg ggccagcctg aactaggtaa tactggcaat     3060

taagattctg tgaagattct atgcatatag tagtgtcatt tgggtgaaaa agagccgttt     3120

taacaatttt gagtacgttt ggctattcta tagcctcttt cttccttccc caaagacgtt     3180

ctacttgcct aactctcaaa ctgttggggt gatacattcc tttgggacca gttaaaatac     3240

agcgttaggg tcggtgacat atgtgactgg ctctggttca gtattctctt atcttaggtc     3300

actgtagtct ctcttgtatg gttgcccaaa attataatgt taaataatct aaagtgagtt     3360

cagacaagta aaatcaaggg aaatagaagg tgaattctat aacttctgta agttgcttga     3420

tattaaaagg ttgagaggca ggttggcccc agactgtata cttttctgac actttacctg     3480

ggaagaaaac atgtacaaag gtcagggtgg aggcatgact gaggaggtcg gcacagcctg     3540

catgtgtgtg ctctctctgc cttacgcctc agtctgtggt tggaagactt tgtactggtg     3600

aatggcaata tgcaggtggg gcagtgtcaa aagcagtttg atttattaat ctccaaataa     3660

caataaatct ccagctttta cacttgaaaa aaa                                  3693


<210>  12
<211>  582
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Glu Ser Ala Glu Ser Gly Gly Pro Pro Gly Ala Gln Asp Ser 
1               5                   10                  15      


Ala Ala Asp Gly Gly Pro Ala Glu Pro Lys Ile Met Lys Val Thr Val 
            20                  25                  30          


Lys Thr Pro Lys Glu Lys Glu Glu Phe Ala Val Pro Glu Asn Ser Ser 
        35                  40                  45              


Val Gln Gln Phe Lys Glu Glu Ile Ser Lys Arg Phe Lys Ser His Ile 
    50                  55                  60                  


Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile Leu Lys Asp Gln Asp 
65                  70                  75                  80  


Thr Leu Ser Gln His Gly Ile His Asp Gly Leu Thr Val His Leu Val 
                85                  90                  95      


Ile Lys Thr Gln Asn Arg Pro Gln Asp Asn Ser Ala Gln Gln Thr Asn 
            100                 105                 110         


Ala Pro Gly Ser Thr Val Thr Ser Ser Pro Ala Pro Asp Ser Asn Pro 
        115                 120                 125             


Thr Ser Gly Ser Ala Ala Asn Ser Ser Phe Gly Val Gly Gly Leu Gly 
    130                 135                 140                 


Gly Leu Ala Gly Leu Ser Ser Leu Gly Leu Asn Thr Thr Asn Phe Ser 
145                 150                 155                 160 


Glu Leu Gln Ser Gln Met Gln Arg Gln Leu Leu Ser Asn Pro Glu Met 
                165                 170                 175     


Met Val Gln Ile Met Glu Asn Pro Phe Val Gln Ser Met Leu Ser Asn 
            180                 185                 190         


Pro Asp Leu Met Arg Gln Leu Ile Met Ala Asn Pro Gln Met Gln Gln 
        195                 200                 205             


Leu Ile Gln Arg Asn Pro Glu Ile Ser His Met Leu Asn Asn Pro Asp 
    210                 215                 220                 


Ile Met Arg Gln Thr Leu Glu Leu Ala Arg Asn Pro Ala Met Met Gln 
225                 230                 235                 240 


Glu Met Met Arg Asn Gln Asp Arg Ala Leu Ser Asn Leu Glu Ser Ile 
                245                 250                 255     


Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr Thr Asp Ile Gln Glu 
            260                 265                 270         


Pro Met Leu Asn Ala Ala Gln Glu Gln Phe Gly Gly Asn Pro Phe Ala 
        275                 280                 285             


Ser Leu Val Ser Ser Ser Ser Ser Ala Glu Gly Thr Gln Pro Ser Arg 
    290                 295                 300                 


Thr Glu Asn Arg Asp Pro Leu Pro Asn Pro Trp Ala Pro Gln Thr Ser 
305                 310                 315                 320 


Gln Ser Ser Pro Ala Ser Gly Thr Thr Gly Ser Thr Thr Asn Thr Met 
                325                 330                 335     


Ser Thr Ser Gly Gly Thr Ala Thr Ser Thr Pro Ala Gly Gln Ser Thr 
            340                 345                 350         


Ser Gly Pro Ser Leu Val Pro Gly Ala Gly Ala Ser Met Phe Asn Thr 
        355                 360                 365             


Pro Gly Met Gln Ser Leu Leu Gln Gln Ile Thr Glu Asn Pro Gln Leu 
    370                 375                 380                 


Met Gln Asn Met Leu Ser Ala Pro Tyr Met Arg Ser Met Leu Gln Ser 
385                 390                 395                 400 


Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln Met Met Leu Asn Asn Pro 
                405                 410                 415     


Leu Phe Ala Gly Asn Pro Gln Leu Gln Glu Gln Met Arg Gln Gln Leu 
            420                 425                 430         


Pro Thr Phe Leu Gln Gln Met Gln Asn Pro Asp Thr Leu Ser Ala Met 
        435                 440                 445             


Ser Asn Pro Arg Ala Met Gln Ala Leu Leu Gln Ile Gln Gln Gly Leu 
    450                 455                 460                 


Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu Ile Pro Gly Phe Thr Pro 
465                 470                 475                 480 


Gly Leu Ala Ala Gly Asn Ser Gly Gly Ser Ser Gly Thr Asn Ala Pro 
                485                 490                 495     


Ser Thr Ala Pro Ser Glu Asp Thr Asn Pro Gln Gly Gly Thr Ala Glu 
            500                 505                 510         


Pro Gly His Gln Gln Phe Ile Gln Gln Met Leu Gln Ala Leu Ala Gly 
        515                 520                 525             


Val Asn Pro Gln Leu Gln Ser Pro Glu Val Arg Phe Gln Gln Gln Leu 
    530                 535                 540                 


Glu Gln Leu Ser Ala Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln 
545                 550                 555                 560 


Ala Leu Ile Ala Thr Gly Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu 
                565                 570                 575     


Leu Gly Ser Gln Pro Ser 
            580         


<210>  13
<211>  3609
<212>  DNA
<213>  Mus musculus

<400>  13
agagtgccct gcgcggcgcc ggcgacgagc gtgggggagg tgcgggagga ggaagcggcg       60

gcgacgcgga gagtccccgc gtccacacgg cagccgatcg cccacccggg gcctgcaccc      120

gcagcccgcg tccacgcacc ctcggcggcc ccgcagcctg tcacgcctcg cggacccggc      180

cgcagcccgc agtgtcgcgc tcgcctgagt caccgccatg gccgagagcg cagagagcgg      240

cggcccaccg ggcgcgcagg acagtgcggc cgacggcggc cccgcagagc ccaagatcat      300

gaaggtcacg gtgaagacgc ctaaagagaa ggaggagttt gccgtgcccg agaacagctc      360

ggtccagcag ttcaaagagg aaatctctaa acgtttcaaa tctcatattg accaacttgt      420

gttgatattt gctggaaaaa ttttaaaaga tcaagatact ctgagtcagc atgggattca      480

tgatggactt acggttcacc ttgtcatcaa aacacagaac aggccgcaag ataattcagc      540

tcagcaaaca aatgcccctg gaagcactgt gaccagctca ccagctcccg atagcaaccc      600

cacgtctggt tctgctgcta acagctcctt tggcgtaggc ggacttggag gacttgcagg      660

tcttagcagc ttgggtttaa acaccaccaa cttctctgaa ctccagagcc aaatgcagcg      720

gcaacttttg tctaaccctg aaatgatggt ccagatcatg gaaaatccct ttgtccagag      780

catgctctca aatcctgacc tgatgcggca attgattatg gccaatccac agatgcaaca      840

gttgatacag agaaatccag agattagtca tatgcttaat aatccagata taatgagaca      900

aacactggaa cttgcgagaa atccagcgat gatgcaggaa atgatgagaa accaggaccg      960

agccttgagc aacctagaaa gtattcctgg gggctataat gccttacggc gcatgtacac     1020

cgatatccag gagcctatgc tgaatgctgc tcaagaacag tttggtggta atccatttgc     1080

gtccttagtg agcagttcgt cctcagcaga agggactcag ccttctcgaa cagaaaatag     1140

ggatccgctc cccaacccgt gggctccgca gacttcccag agctcaccag cctccggtac     1200

cactggcagc accactaaca ccatgagcac ctctggtggc actgccacca gtacccctgc     1260

tggacagagc acctcgggcc caagcttggt gcctggcgca ggagctagta tgttcaacac     1320

ccccggaatg cagagcctgc tgcagcagat aactgagaac ccacagctca tgcagaacat     1380

gctgtccgcc ccatacatga ggagcatgct gcagtccctg agccagaacc ccgaccttgc     1440

tgcgcagatg cagaaccccg acacgctctc agcgatgtcg aatcctagag ccatgcaggc     1500

gctgctgcag atccagcagg gcttgcagac gctggccaca gaagctcctg gcctcatccc     1560

agggtttact cctggcttgg cagcaggcaa ttctggaggc tcttccggaa ccaatgcacc     1620

tagcactgca cctagtgaag atacgaaccc ccaagggggc actgctgagc caggccacca     1680

gcagtttatc cagcagatgc tgcaggccct tgcgggggtg aatcctcagc tgcagagtcc     1740

agaagtcaga tttcagcaac aactggaaca actcagtgcc atgggattct tgaaccgtga     1800

agcaaacctg caagctctga tagccacagg gggcgacatc aatgcagcaa tcgaaaggtt     1860

gctgggctcc cagccgtcat agcagcatct ctctatcctg agaaaatgta atttattttt     1920

gataacggct cttaaatctt taaaataaca tgctttattt cattgggatt ctgtgctgtt     1980

ataaaggaaa ccaataggaa gtatctggag gcagagtgca gtacgacggg cgggtttctg     2040

tgtctttttg gaacagtggg aatcaatgtt tcttctggtt aaggctgctg catgcatcaa     2100

acacttggca tttattgtaa tttttaaaaa aatatcacct tttctaattg ggtgaacaaa     2160

tttttgtcct gcatctgtcc aactaacttg ctttttaaac ataaccctat ggtagtaatt     2220

tatgtagaat aaaggcatta aaaagcagat catttgcgcg ccccatgatt tctggtacaa     2280

tagtgcttgt tgtgactttg gcatgcactt tgcaaatgat gctgtaagat ttatactcct     2340

gacaattttg tttatttgta tacaatacaa attattgcac atttctaggc catctaagca     2400

aaatttctgt aactaaaaaa gtacaataag gattcctaat tgtgtagaat cttacagcat     2460

ctttgataaa catctcagca gaagtgccat ttagtctgtg tggaaaataa agaaaaacta     2520

actctggtta tctctttagg gacatttaat tgtacagaca acataatgta acaatatctc     2580

agcattatat aatggctgta aattaccttt ccttgtgccg actggaggag cactgtatca     2640

tgctctgatg tgtttgctgg ggcgtcctgc tccccgtagg tgtcgtctac gcagcattga     2700

gtttattgaa atgtcgcttt cactggaagt gcggatgttt cggttctaat tgccatataa     2760

aagtagagct gtctcttggg tttatcagct ttctcattca taggcaatac ctcgatttta     2820

aatgattagt gagccacttg tttctcaagt gtttggctag ttctattaag aaatagttga     2880

atgtcgtgct gttcggagcc tcagaagggg gtgggggagg ggtgaaacag aatctattct     2940

ggattgggcc agcctgaact aggtaatact ggcaattaag attctgtgaa gattctatgc     3000

atatagtagt gtcatttggg tgaaaaagag ccgttttaac aattttgagt acgtttggct     3060

attctatagc ctctttcttc cttccccaaa gacgttctac ttgcctaact ctcaaactgt     3120

tggggtgata cattcctttg ggaccagtta aaatacagcg ttagggtcgg tgacatatgt     3180

gactggctct ggttcagtat tctcttatct taggtcactg tagtctctct tgtatggttg     3240

cccaaaatta taatgttaaa taatctaaag tgagttcaga caagtaaaat caagggaaat     3300

agaaggtgaa ttctataact tctgtaagtt gcttgatatt aaaaggttga gaggcaggtt     3360

ggccccagac tgtatacttt tctgacactt tacctgggaa gaaaacatgt acaaaggtca     3420

gggtggaggc atgactgagg aggtcggcac agcctgcatg tgtgtgctct ctctgcctta     3480

cgcctcagtc tgtggttgga agactttgta ctggtgaatg gcaatatgca ggtggggcag     3540

tgtcaaaagc agtttgattt attaatctcc aaataacaat aaatctccag cttttacact     3600

tgaaaaaaa                                                             3609


<210>  14
<211>  554
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Glu Ser Ala Glu Ser Gly Gly Pro Pro Gly Ala Gln Asp Ser 
1               5                   10                  15      


Ala Ala Asp Gly Gly Pro Ala Glu Pro Lys Ile Met Lys Val Thr Val 
            20                  25                  30          


Lys Thr Pro Lys Glu Lys Glu Glu Phe Ala Val Pro Glu Asn Ser Ser 
        35                  40                  45              


Val Gln Gln Phe Lys Glu Glu Ile Ser Lys Arg Phe Lys Ser His Ile 
    50                  55                  60                  


Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile Leu Lys Asp Gln Asp 
65                  70                  75                  80  


Thr Leu Ser Gln His Gly Ile His Asp Gly Leu Thr Val His Leu Val 
                85                  90                  95      


Ile Lys Thr Gln Asn Arg Pro Gln Asp Asn Ser Ala Gln Gln Thr Asn 
            100                 105                 110         


Ala Pro Gly Ser Thr Val Thr Ser Ser Pro Ala Pro Asp Ser Asn Pro 
        115                 120                 125             


Thr Ser Gly Ser Ala Ala Asn Ser Ser Phe Gly Val Gly Gly Leu Gly 
    130                 135                 140                 


Gly Leu Ala Gly Leu Ser Ser Leu Gly Leu Asn Thr Thr Asn Phe Ser 
145                 150                 155                 160 


Glu Leu Gln Ser Gln Met Gln Arg Gln Leu Leu Ser Asn Pro Glu Met 
                165                 170                 175     


Met Val Gln Ile Met Glu Asn Pro Phe Val Gln Ser Met Leu Ser Asn 
            180                 185                 190         


Pro Asp Leu Met Arg Gln Leu Ile Met Ala Asn Pro Gln Met Gln Gln 
        195                 200                 205             


Leu Ile Gln Arg Asn Pro Glu Ile Ser His Met Leu Asn Asn Pro Asp 
    210                 215                 220                 


Ile Met Arg Gln Thr Leu Glu Leu Ala Arg Asn Pro Ala Met Met Gln 
225                 230                 235                 240 


Glu Met Met Arg Asn Gln Asp Arg Ala Leu Ser Asn Leu Glu Ser Ile 
                245                 250                 255     


Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr Thr Asp Ile Gln Glu 
            260                 265                 270         


Pro Met Leu Asn Ala Ala Gln Glu Gln Phe Gly Gly Asn Pro Phe Ala 
        275                 280                 285             


Ser Leu Val Ser Ser Ser Ser Ser Ala Glu Gly Thr Gln Pro Ser Arg 
    290                 295                 300                 


Thr Glu Asn Arg Asp Pro Leu Pro Asn Pro Trp Ala Pro Gln Thr Ser 
305                 310                 315                 320 


Gln Ser Ser Pro Ala Ser Gly Thr Thr Gly Ser Thr Thr Asn Thr Met 
                325                 330                 335     


Ser Thr Ser Gly Gly Thr Ala Thr Ser Thr Pro Ala Gly Gln Ser Thr 
            340                 345                 350         


Ser Gly Pro Ser Leu Val Pro Gly Ala Gly Ala Ser Met Phe Asn Thr 
        355                 360                 365             


Pro Gly Met Gln Ser Leu Leu Gln Gln Ile Thr Glu Asn Pro Gln Leu 
    370                 375                 380                 


Met Gln Asn Met Leu Ser Ala Pro Tyr Met Arg Ser Met Leu Gln Ser 
385                 390                 395                 400 


Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln Met Gln Asn Pro Asp Thr 
                405                 410                 415     


Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Ala Leu Leu Gln Ile 
            420                 425                 430         


Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu Ile Pro 
        435                 440                 445             


Gly Phe Thr Pro Gly Leu Ala Ala Gly Asn Ser Gly Gly Ser Ser Gly 
    450                 455                 460                 


Thr Asn Ala Pro Ser Thr Ala Pro Ser Glu Asp Thr Asn Pro Gln Gly 
465                 470                 475                 480 


Gly Thr Ala Glu Pro Gly His Gln Gln Phe Ile Gln Gln Met Leu Gln 
                485                 490                 495     


Ala Leu Ala Gly Val Asn Pro Gln Leu Gln Ser Pro Glu Val Arg Phe 
            500                 505                 510         


Gln Gln Gln Leu Glu Gln Leu Ser Ala Met Gly Phe Leu Asn Arg Glu 
        515                 520                 525             


Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly Gly Asp Ile Asn Ala Ala 
    530                 535                 540                 


Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
545                 550                 


<210>  15
<211>  2879
<212>  DNA
<213>  Homo sapiens

<400>  15
gattggtggg ttcatgtttc ccgtcccccg cccgcgggaa gtgggggtga aaagcggccc       60

gacctgcttg cggtgtagtg ggcggaccgc gcggctggag gtgtgaggat ccgaacccag      120

gggtgggggg tggaggcggc tcctgcgatc gaaggggact tgagactcac cggccgcacg      180

ccatgagggc cctgtgggtg ctgggcctct gctgcgtcct gctgaccttc gggtcggtca      240

gagctgacga tgaagttgat gtggatggta cagtagaaga ggatctgggt aaaagtagag      300

aaggatcaag gacggatgat gaagtagtac agagagagga agaagctatt cagttggatg      360

gattaaatgc atcacaaata agagaactta gagagaagtc ggaaaagttt gccttccaag      420

ccgaagttaa cagaatgatg aaacttatca tcaattcatt gtataaaaat aaagagattt      480

tcctgagaga actgatttca aatgcttctg atgctttaga taagataagg ctaatatcac      540

tgactgatga aaatgctctt tctggaaatg aggaactaac agtcaaaatt aagtgtgata      600

aggagaagaa cctgctgcat gtcacagaca ccggtgtagg aatgaccaga gaagagttgg      660

ttaaaaacct tggtaccata gccaaatctg ggacaagcga gtttttaaac aaaatgactg      720

aagcacagga agatggccag tcaacttctg aattgattgg ccagtttggt gtcggtttct      780

attccgcctt ccttgtagca gataaggtta ttgtcacttc aaaacacaac aacgataccc      840

agcacatctg ggagtctgac tccaatgaat tttctgtaat tgctgaccca agaggaaaca      900

ctctaggacg gggaacgaca attacccttg tcttaaaaga agaagcatct gattaccttg      960

aattggatac aattaaaaat ctcgtcaaaa aatattcaca gttcataaac tttcctattt     1020

atgtatggag cagcaagact gaaactgttg aggagcccat ggaggaagaa gaagcagcca     1080

aagaagagaa agaagaatct gatgatgaag ctgcagtaga ggaagaagaa gaagaaaaga     1140

aaccaaagac taaaaaagtt gaaaaaactg tctgggactg ggaacttatg aatgatatca     1200

aaccaatatg gcagagacca tcaaaagaag tagaagaaga tgaatacaaa gctttctaca     1260

aatcattttc aaaggaaagt gatgacccca tggcttatat tcactttact gctgaagggg     1320

aagttacctt caaatcaatt ttatttgtac ccacatctgc tccacgtggt ctgtttgacg     1380

aatatggatc taaaaagagc gattacatta agctctatgt gcgccgtgta ttcatcacag     1440

acgacttcca tgatatgatg cctaaatacc tcaattttgt caagggtgtg gtggactcag     1500

atgatctccc cttgaatgtt tcccgcgaga ctcttcagca acataaactg cttaaggtga     1560

ttaggaagaa gcttgttcgt aaaacgctgg acatgatcaa gaagattgct gatgataaat     1620

acaatgatac tttttggaaa gaatttggta ccaacatcaa gcttggtgtg attgaagacc     1680

actcgaatcg aacacgtctt gctaaacttc ttaggttcca gtcttctcat catccaactg     1740

acattactag cctagaccag tatgtggaaa gaatgaagga aaaacaagac aaaatctact     1800

tcatggctgg gtccagcaga aaagaggctg aatcttctcc atttgttgag cgacttctga     1860

aaaagggcta tgaagttatt tacctcacag aacctgtgga tgaatactgt attcaggccc     1920

ttcccgaatt tgatgggaag aggttccaga atgttgccaa ggaaggagtg aagttcgatg     1980

aaagtgagaa aactaaggag agtcgtgaag cagttgagaa agaatttgag cctctgctga     2040

attggatgaa agataaagcc cttaaggaca agattgaaaa ggctgtggtg tctcagcgcc     2100

tgacagaatc tccgtgtgct ttggtggcca gccagtacgg atggtctggc aacatggaga     2160

gaatcatgaa agcacaagcg taccaaacgg gcaaggacat ctctacaaat tactatgcga     2220

gtcagaagaa aacatttgaa attaatccca gacacccgct gatcagagac atgcttcgac     2280

gaattaagga agatgaagat gataaaacag ttttggatct tgctgtggtt ttgtttgaaa     2340

cagcaacgct tcggtcaggg tatcttttac cagacactaa agcatatgga gatagaatag     2400

aaagaatgct tcgcctcagt ttgaacattg accctgatgc aaaggtggaa gaagagcccg     2460

aagaagaacc tgaagagaca gcagaagaca caacagaaga cacagagcaa gacgaagatg     2520

aagaaatgga tgtgggaaca gatgaagaag aagaaacagc aaaggaatct acagctgaaa     2580

aagatgaatt gtaaattata ctctcaccat ttggatcctg tgtggagagg gaatgtgaaa     2640

tttacatcat ttctttttgg gagagacttg ttttggatgc cccctaatcc ccttctcccc     2700

tgcactgtaa aatgtgggat tatgggtcac aggaaaaagt gggtttttta gttgaatttt     2760

ttttaacatt cctcatgaat gtaaatttgt actatttaac tgactattct tgatgtaaaa     2820

tcttgtcatg tgtataaaaa taaaaaagat cccaaatact caaaaaaaaa aaaaaaaaa      2879


<210>  16
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  17
<211>  2759
<212>  DNA
<213>  Mus musculus

<400>  17
tggaggtgtg aggagcttag actcgggatt gggggggtgg aggcggctcc tgagaccgaa       60

aaggacttgc gactcgccgg ccacgcacca tgagggtcct gtgggtgttg ggcctctgct      120

gtgtcctgct gaccttcggg ttcgtcagag ctgatgatga agtcgacgtg gatggcacag      180

tggaagagga cctgggtaaa agccgagaag gctcaaggac agatgatgaa gttgtgcaga      240

gagaggaaga agctattcag ttggatgggt taaacgcatc acagataaga gaacttagag      300

aaaaatctga aaagttcgcc ttccaagctg aagtgaacag gatgatgaaa cttatcatca      360

attctttgta taaaaataaa gagattttcc tgagagaact gatttcaaat gcttctgatg      420

ctttagacaa gataaggctc atctccctaa ctgatgaaaa tgcactcgct ggaaatgagg      480

agttaacggt caagattaag tgtgacaaag agaaaaacct gctgcatgtc acagacacgg      540

gtgtaggaat gactagagag gagttggtta aaaatctcgg caccatagcc aaatctggaa      600

caagcgagtt tttaaacaaa atgacagaag ctcaagaaga tggtcagtca acctctgaac      660

tgattggcca gtttggtgtc ggtttttatt ctgccttcct tgtagcagat aaggtcattg      720

tcacatcgaa acacaacaat gatacccagc acatctggga atcagactcc aatgaattct      780

ctgtaattgc tgacccaaga ggaaacacac taggtcgtgg aacaacaatt actcttgtct      840

taaaagaaga agcatctgat taccttgaat tggacacaat taaaaatctt gtcaggaagt      900

actctcagtt catcaacttt cccatctacg tgtggagtag caagacagag actgttgagg      960

agcccttgga agaagatgaa gcagcaaaag aagagaaaga agaatctgat gatgaagctg     1020

cagtagagga ggaagaagaa gaaaagaaac caaaaactaa gaaagttgaa aaaactgtgt     1080

gggattggga acttatgaat gatatcaaac caatatggca gagaccatcc aaagaagtag     1140

aagaagacga atacaaagct ttctacaaat cattttcaaa ggaaagtgat gaccccatgg     1200

cttatatcca cttcactgca gaaggggagg tcaccttcaa gtcgattttg tttgtaccca     1260

catctgcacc tcgaggtctg tttgatgaat atggatctaa gaagagtgat tatattaagc     1320

tgtatgtacg ccgcgtattc atcacagatg acttccatga tatgatgccc aaatacctta     1380

attttgtcaa aggtgttgtg gattccgatg atctccccct caatgtttcc cgtgagactc     1440

ttcagcaaca taaattgctc aaggtgatta ggaagaagct tgtccgaaaa actctggaca     1500

tgatcaagaa gattgctgat gagaagtata acgacacttt ctggaaggag ttcggcacga     1560

atatcaagct tggtgtgatt gaagaccact caaatcgaac acggcttgct aaacttctta     1620

ggttccagtc ttctcaccat tcaactgaca ttactagttt agaccagtat gtggaaagaa     1680

tgaaggaaaa acaggacaaa atctacttca tggctgggtc aagcagaaag gaggcggaat     1740

cttctccatt tgttgagaga cttctgaaga agggctatga agtcatttat ctcacagagc     1800

ctgtggatga atactgcatt caggctcttc ccgagtttga tgggaagagg tttcagaatg     1860

ttgccaaaga aggggtgaag tttgatgaga gtgagaaaac taaagaaagt cgggaagcaa     1920

cagagaagga gtttgaacct ctgctcaact ggatgaaaga taaggccctc aaggacaaga     1980

tagaaaaggc tgtggtgtcg cagcgcctca cagagtctcc ctgtgctctt gtggccagtc     2040

agtatggatg gtctggcaac atggagagga tcatgaaggc acaagcatac cagacgggca     2100

aggacatctc tacaaattac tatgccagtc aaaagaaaac gttcgaaatc aatcctagac     2160

acccactgat cagagacatg ttgcggcgga ttaaggaaga tgaagatgac aagacagtca     2220

tggatcttgc tgtagttttg tttgaaacgg caacacttcg gtcaggatat cttctaccag     2280

acaccaaggc gtatggagat agaatagaaa gaatgcttcg cctcagttta aacattgacc     2340

ctgaagcaca ggtggaggaa gaaccagaag aagagcctga agacacctca gaagacgcag     2400

aagactcaga gcaggatgag ggagaagaga tggatgcagg gacagaagaa gaagaggagg     2460

aaacagaaaa ggaatctaca gagaaggatg aattgtaaat tatactctcg ctatgaatcc     2520

cgtgtggaga gggaatgtga agttttgaag tcatttcttt tgagagactt gttttggatg     2580

cttccccaag cctccttctc ccctgcactg taaaatgttg ggattatggg tcacaggaag     2640

aagtggtttt tttagttgaa ttttttttaa cattcctcct gaatgtaaat ttgtactatt     2700

taactgacta ttggtgtaaa atcttgtcat gtgtataaaa ataaaaaaag atcccaaat      2759


<210>  18
<211>  802
<212>  PRT
<213>  Mus musculus

<400>  18

Met Arg Val Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Phe Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ala Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Arg Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Leu Glu Glu Asp Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Glu Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Ser Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Thr Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Met Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Glu 
            740                 745                 750         


Ala Gln Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Asp Thr Ser Glu 
        755                 760                 765             


Asp Ala Glu Asp Ser Glu Gln Asp Glu Gly Glu Glu Met Asp Ala Gly 
    770                 775                 780                 


Thr Glu Glu Glu Glu Glu Glu Thr Glu Lys Glu Ser Thr Glu Lys Asp 
785                 790                 795                 800 


Glu Leu 


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  19
gcctgctgtc acttgctacg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  20
aatcaaccag agaatttccg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  21
ggtccagctc ccgttctaca                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  22
gtatggcagc aacgtcacga                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  23
tatagagctg aaaaaccgca                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  24
ccacattacg gacgatgcaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  25
tcttacgagg aggagaaagg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  26
gcaagtgtag tttcccacca                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  27
gcgaggtatt cggctccgcg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  28
gctttcacgg aggttcgacg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  29
atgttgcagt tcggctcgat                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  30
acgtgtaagg cgaacgcctt                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  31
attgttcgac cgtctacggg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  32
gcattgctaa gaagaagcgc                                                   20