                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Modulating Biomarkers To Increase Tumor Immunity And Improve The 
       Efficacy Of Cancer Immunotherapy

<130>  DFS-186.25

<140>  PCT/US2018/042241
<141>  2018-07-16

<150>  US 60/532,593
<151>  2017-07-14

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  4096
<212>  DNA
<213>  Homo sapiens

<400>  1
agactgctcg tcaagtgtgg gaaaagctcc gtggcgtcac aagctactat ataaaaggcg       60

gtgcccgccg gggccgagtg ggagtccgcg gcgagcgcag cagcagggcc cggtcctgcg      120

cctcgggagt cggcgtccag gctcggagcg cgacacggag actaggtggc agggtacagc      180

tctgccgggg ggggaaaaag tggtaccatt ttgggcgttc ttgagcttca gaatgcaacc      240

agacatgtcc ttgaatgtca ttaagatgaa atccagtgac ttcctggaga gtgcagaact      300

ggacagcgga ggctttggga aggtgtctct gtgtttccac agaacccagg gactcatgat      360

catgaaaaca gtgtacaagg ggcccaactg cattgagcac aacgaggccc tcttggagga      420

ggcgaagatg atgaacagac tgagacacag ccgggtggtg aagctcctgg gcgtcatcat      480

agaggaaggg aagtactccc tggtgatgga gtacatggag aagggcaacc tgatgcacgt      540

gctgaaagcc gagatgagta ctccgctttc tgtaaaagga aggataattt tggaaatcat      600

tgaaggaatg tgctacttac atggaaaagg cgtgatacac aaggacctga agcctgaaaa      660

tatccttgtt gataatgact tccacattaa gatcgcagac ctcggccttg cctcctttaa      720

gatgtggagc aaactgaata atgaagagca caatgagctg agggaagtgg acggcaccgc      780

taagaagaat ggcggcaccc tctactacat ggcgcccgag cacctgaatg acgtcaacgc      840

aaagcccaca gagaagtcgg atgtgtacag ctttgctgta gtactctggg cgatatttgc      900

aaataaggag ccatatgaaa atgctatctg tgagcagcag ttgataatgt gcataaaatc      960

tgggaacagg ccagatgtgg atgacatcac tgagtactgc ccaagagaaa ttatcagtct     1020

catgaagctc tgctgggaag cgaatccgga agctcggccg acatttcctg gcattgaaga     1080

aaaatttagg cctttttatt taagtcaatt agaagaaagt gtagaagagg acgtgaagag     1140

tttaaagaaa gagtattcaa acgaaaatgc agttgtgaag agaatgcagt ctcttcaact     1200

tgattgtgtg gcagtacctt caagccggtc aaattcagcc acagaacagc ctggttcact     1260

gcacagttcc cagggacttg ggatgggtcc tgtggaggag tcctggtttg ctccttccct     1320

ggagcaccca caagaagaga atgagcccag cctgcagagt aaactccaag acgaagccaa     1380

ctaccatctt tatggcagcc gcatggacag gcagacgaaa cagcagccca gacagaatgt     1440

ggcttacaac agagaggagg aaaggagacg cagggtctcc catgaccctt ttgcacagca     1500

aagaccttac gagaattttc agaatacaga gggaaaaggc actgcttatt ccagtgcagc     1560

cagtcatggt aatgcagtgc accagccctc agggctcacc agccaacctc aagtactgta     1620

tcagaacaat ggattatata gctcacatgg ctttggaaca agaccactgg atccaggaac     1680

agcaggtccc agagtttggt acaggccaat tccaagtcat atgcctagtc tgcataatat     1740

cccagtgcct gagaccaact atctaggaaa tacacccacc atgccattca gctccttgcc     1800

accaacagat gaatctataa aatataccat atacaatagt actggcattc agattggagc     1860

ctacaattat atggagattg gtgggacgag ttcatcacta ctagacagca caaatacgaa     1920

cttcaaagaa gagccagctg ctaagtacca agctatcttt gataatacca ctagtctgac     1980

ggataaacac ctggacccaa tcagggaaaa tctgggaaag cactggaaaa actgtgcccg     2040

taaactgggc ttcacacagt ctcagattga tgaaattgac catgactatg agcgagatgg     2100

actgaaagaa aaggtttacc agatgctcca aaagtgggtg atgagggaag gcataaaggg     2160

agccacggtg gggaagctgg cccaggcgct ccaccagtgt tccaggatcg accttctgag     2220

cagcttgatt tacgtcagcc agaactaacc ctggatgggc tacggcagct gaagtggacg     2280

cctcacttag tggataaccc cagaaagttg gctgcctcag agcattcaga attctgtcct     2340

cactgatagg ggttctgtgt ctgcagaaat tttgtttcct gtacttcata gctggagaat     2400

ggggaaagaa atctgcagca aaggggtctc actctgttgc caggctggtc tcaaacttct     2460

ggactcaagt gatcctcccg cctcggcctt ccaaagtgct gggatatcag gcactgagcc     2520

actgcgccca gccaacaatc cgctctgagg aaagcgtaag caggaagacc tcttaatggc     2580

atagcaccaa taaaaaaatg actcctagtt gtgtttggaa agggagagaa gagatgtctg     2640

aggaaggtca tgttctttca gcttatggca tttcctagag ttttgttgaa gcaagaagaa     2700

aaactcagag aatataaaat caacttttaa aattgtgtgc tctcttcttc acgtaggctc     2760

ctgttaaaaa caaagtgcag tcagattcta agccctgttc agagacttcg tggatcacag     2820

ctgcagctca ccgccacatc acaggatccg ttaacgttaa tacccaatac tctgtcagcc     2880

actgtaggct ctaagaacca cgtgcagtct tcagcccatt aaattatcga ttatttttta     2940

atgaattgaa tttatattga gtcttcaaat taactgaatg gatttaaagg ggtaccaagg     3000

aggggggaaa catcagaatt tcccaggcag ttgttgcaag gaattggtac taaccgtgac     3060

tacaacaaaa attcttgatt gacttttaaa gttatttcct ggcattctgg taccttcacc     3120

cagcctgagt gccctggaga gggaacagga aatgctgatc tctacccctg ggtgagacca     3180

gaacctcagg gctgatactg ttgagtggct tcctcggttt actctgtgta ctgtgaaagt     3240

attttcatat tttttctgtg tgccagagtg aaaaaggaca gcttctgagt gtggtaattg     3300

tgcctctagc acccagcctt tcaaagccca cctgaaacct gggggtggat gaaagaacta     3360

gaatagaaga ctgaagctgg gtaggccgct cagtgtccac tggcattttg ctaaaccgac     3420

aaggaaggct gtgtgcttag ctctccccag agggagggcg agaagggtgt ggtgatggtc     3480

aatctggctg tcggaacaga ttctggtgtc ttgggctgat aacagtgttg ttgattctga     3540

ttgtgaatcc cctcaactct agcagacaca tacacacccc tgaaatgggg ctgcagagca     3600

ggctgtctca gccttgccac tgtcggcatc tcggcctggg taattctgtt gtggggactg     3660

tcctgttcct tgtaggatgt ttagtagcat ccctgccccc acctactaga tgccaggggc     3720

actgttctcc ccagcccccc gccccagttg tgacaatagt ctctaaacat tgtcaaatgg     3780

tccaaggaaa ggggaaaatt gccccggttg agaagagcac tgctgtaaag taatgagcct     3840

cggctctcct gtctgcacct gtccggttac tacttggcca ccacgcagcc ttggctccta     3900

cagcccaaaa gggagaatgg agggaggctc caggctttgc tggaggggcc tgggtgagtt     3960

ctgtttgctc cttgtaccac catccaaatg gtgttatcaa atctcttaga ttccaaagag     4020

gttgaataat taatgttcaa aggcaagagg gcaaggcatt ttttaacact ttttaaaata     4080

aaaatttata ccacaa                                                     4096


<210>  2
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Pro Asp Met Ser Leu Asn Val Ile Lys Met Lys Ser Ser Asp 
1               5                   10                  15      


Phe Leu Glu Ser Ala Glu Leu Asp Ser Gly Gly Phe Gly Lys Val Ser 
            20                  25                  30          


Leu Cys Phe His Arg Thr Gln Gly Leu Met Ile Met Lys Thr Val Tyr 
        35                  40                  45              


Lys Gly Pro Asn Cys Ile Glu His Asn Glu Ala Leu Leu Glu Glu Ala 
    50                  55                  60                  


Lys Met Met Asn Arg Leu Arg His Ser Arg Val Val Lys Leu Leu Gly 
65                  70                  75                  80  


Val Ile Ile Glu Glu Gly Lys Tyr Ser Leu Val Met Glu Tyr Met Glu 
                85                  90                  95      


Lys Gly Asn Leu Met His Val Leu Lys Ala Glu Met Ser Thr Pro Leu 
            100                 105                 110         


Ser Val Lys Gly Arg Ile Ile Leu Glu Ile Ile Glu Gly Met Cys Tyr 
        115                 120                 125             


Leu His Gly Lys Gly Val Ile His Lys Asp Leu Lys Pro Glu Asn Ile 
    130                 135                 140                 


Leu Val Asp Asn Asp Phe His Ile Lys Ile Ala Asp Leu Gly Leu Ala 
145                 150                 155                 160 


Ser Phe Lys Met Trp Ser Lys Leu Asn Asn Glu Glu His Asn Glu Leu 
                165                 170                 175     


Arg Glu Val Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr Leu Tyr Tyr 
            180                 185                 190         


Met Ala Pro Glu His Leu Asn Asp Val Asn Ala Lys Pro Thr Glu Lys 
        195                 200                 205             


Ser Asp Val Tyr Ser Phe Ala Val Val Leu Trp Ala Ile Phe Ala Asn 
    210                 215                 220                 


Lys Glu Pro Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu Ile Met Cys 
225                 230                 235                 240 


Ile Lys Ser Gly Asn Arg Pro Asp Val Asp Asp Ile Thr Glu Tyr Cys 
                245                 250                 255     


Pro Arg Glu Ile Ile Ser Leu Met Lys Leu Cys Trp Glu Ala Asn Pro 
            260                 265                 270         


Glu Ala Arg Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe Arg Pro Phe 
        275                 280                 285             


Tyr Leu Ser Gln Leu Glu Glu Ser Val Glu Glu Asp Val Lys Ser Leu 
    290                 295                 300                 


Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val Lys Arg Met Gln Ser 
305                 310                 315                 320 


Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser Arg Ser Asn Ser Ala 
                325                 330                 335     


Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gly Met Gly 
            340                 345                 350         


Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu Glu His Pro Gln Glu 
        355                 360                 365             


Glu Asn Glu Pro Ser Leu Gln Ser Lys Leu Gln Asp Glu Ala Asn Tyr 
    370                 375                 380                 


His Leu Tyr Gly Ser Arg Met Asp Arg Gln Thr Lys Gln Gln Pro Arg 
385                 390                 395                 400 


Gln Asn Val Ala Tyr Asn Arg Glu Glu Glu Arg Arg Arg Arg Val Ser 
                405                 410                 415     


His Asp Pro Phe Ala Gln Gln Arg Pro Tyr Glu Asn Phe Gln Asn Thr 
            420                 425                 430         


Glu Gly Lys Gly Thr Ala Tyr Ser Ser Ala Ala Ser His Gly Asn Ala 
        435                 440                 445             


Val His Gln Pro Ser Gly Leu Thr Ser Gln Pro Gln Val Leu Tyr Gln 
    450                 455                 460                 


Asn Asn Gly Leu Tyr Ser Ser His Gly Phe Gly Thr Arg Pro Leu Asp 
465                 470                 475                 480 


Pro Gly Thr Ala Gly Pro Arg Val Trp Tyr Arg Pro Ile Pro Ser His 
                485                 490                 495     


Met Pro Ser Leu His Asn Ile Pro Val Pro Glu Thr Asn Tyr Leu Gly 
            500                 505                 510         


Asn Thr Pro Thr Met Pro Phe Ser Ser Leu Pro Pro Thr Asp Glu Ser 
        515                 520                 525             


Ile Lys Tyr Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr 
    530                 535                 540                 


Asn Tyr Met Glu Ile Gly Gly Thr Ser Ser Ser Leu Leu Asp Ser Thr 
545                 550                 555                 560 


Asn Thr Asn Phe Lys Glu Glu Pro Ala Ala Lys Tyr Gln Ala Ile Phe 
                565                 570                 575     


Asp Asn Thr Thr Ser Leu Thr Asp Lys His Leu Asp Pro Ile Arg Glu 
            580                 585                 590         


Asn Leu Gly Lys His Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe Thr 
        595                 600                 605             


Gln Ser Gln Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly Leu 
    610                 615                 620                 


Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp Val Met Arg Glu Gly 
625                 630                 635                 640 


Ile Lys Gly Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln Cys 
                645                 650                 655     


Ser Arg Ile Asp Leu Leu Ser Ser Leu Ile Tyr Val Ser Gln Asn 
            660                 665                 670     


<210>  3
<211>  4374
<212>  DNA
<213>  Homo sapiens

<400>  3
agactgctcg tcaagtgtgg gaaaagctcc gtggcgtcac aagctactat ataaaaggcg       60

gtgcccgccg gggccgagtg ggagtccgcg gcgagcgcag cagcagggcc cggtcctgcg      120

cctcgggagt cggcgtccag gctcggagcg cgacacggag actaggtggc aggaaagaag      180

gcccataggt gctgctgtat gagcttcctc cgctagacag agctggcccc agcctttaga      240

tgaggtgtag aaggctggtt acccgggtca cctgtagccg gccactgtgc aacaccatgg      300

gcagcctagg agtttccaga gtcccctctc cccaagggta cagctctgcc ggggggggaa      360

aaagtggtac cattttgggc gttcttgagc ttcagaatgc aaccagacat gtccttgaat      420

gtcattaaga tgaaatccag tgacttcctg gagagtgcag aactggacag cggaggcttt      480

gggaaggtgt ctctgtgttt ccacagaacc cagggactca tgatcatgaa aacagtgtac      540

aaggggccca actgcattga gcacaacgag gccctcttgg aggaggcgaa gatgatgaac      600

agactgagac acagccgggt ggtgaagctc ctgggcgtca tcatagagga agggaagtac      660

tccctggtga tggagtacat ggagaagggc aacctgatgc acgtgctgaa agccgagatg      720

agtactccgc tttctgtaaa aggaaggata attttggaaa tcattgaagg aatgtgctac      780

ttacatggaa aaggcgtgat acacaaggac ctgaagcctg aaaatatcct tgttgataat      840

gacttccaca ttaaggttca ggctacagct caaaacaagc aacactgcag tccttatcct      900

cagtgtgtct ttgggatcct tggacacttg catccatggg cctctggacg ccatttgggg      960

aaatagaaga tcgcagacct cggccttgcc tcctttaaga tgtggagcaa actgaataat     1020

gaagagcaca atgagctgag ggaagtggac ggcaccgcta agaagaatgg cggcaccctc     1080

tactacatgg cgcccgagca cctgaatgac gtcaacgcaa agcccacaga gaagtcggat     1140

gtgtacagct ttgctgtagt actctgggcg atatttgcaa ataaggagcc atatgaaaat     1200

gctatctgtg agcagcagtt gataatgtgc ataaaatctg ggaacaggcc agatgtggat     1260

gacatcactg agtactgccc aagagaaatt atcagtctca tgaagctctg ctgggaagcg     1320

aatccggaag ctcggccgac atttcctggc attgaagaaa aatttaggcc tttttattta     1380

agtcaattag aagaaagtgt agaagaggac gtgaagagtt taaagaaaga gtattcaaac     1440

gaaaatgcag ttgtgaagag aatgcagtct cttcaacttg attgtgtggc agtaccttca     1500

agccggtcaa attcagccac agaacagcct ggttcactgc acagttccca gggacttggg     1560

atgggtcctg tggaggagtc ctggtttgct ccttccctgg agcacccaca agaagagaat     1620

gagcccagcc tgcagagtaa actccaagac gaagccaact accatcttta tggcagccgc     1680

atggacaggc agacgaaaca gcagcccaga cagaatgtgg cttacaacag agaggaggaa     1740

aggagacgca gggtctccca tgaccctttt gcacagcaaa gaccttacga gaattttcag     1800

aatacagagg gaaaaggcac tgcttattcc agtgcagcca gtcatggtaa tgcagtgcac     1860

cagccctcag ggctcaccag ccaacctcaa gtactgtatc agaacaatgg attatatagc     1920

tcacatggct ttggaacaag accactggat ccaggaacag caggtcccag agtttggtac     1980

aggccaattc caagtcatat gcctagtctg cataatatcc cagtgcctga gaccaactat     2040

ctaggaaata cacccaccat gccattcagc tccttgccac caacagatga atctataaaa     2100

tataccatat acaatagtac tggcattcag attggagcct acaattatat ggagattggt     2160

gggacgagtt catcactact agacagcaca aatacgaact tcaaagaaga gccagctgct     2220

aagtaccaag ctatctttga taataccact agtctgacgg ataaacacct ggacccaatc     2280

agggaaaatc tgggaaagca ctggaaaaac tgtgcccgta aactgggctt cacacagtct     2340

cagattgatg aaattgacca tgactatgag cgagatggac tgaaagaaaa ggtttaccag     2400

atgctccaaa agtgggtgat gagggaaggc ataaagggag ccacggtggg gaagctggcc     2460

caggcgctcc accagtgttc caggatcgac cttctgagca gcttgattta cgtcagccag     2520

aactaaccct ggatgggcta cggcagctga agtggacgcc tcacttagtg gataacccca     2580

gaaagttggc tgcctcagag cattcagaat tctgtcctca ctgatagggg ttctgtgtct     2640

gcagaaattt tgtttcctgt acttcatagc tggagaatgg ggaaagaaat ctgcagcaaa     2700

ggggtctcac tctgttgcca ggctggtctc aaacttctgg actcaagtga tcctcccgcc     2760

tcggccttcc aaagtgctgg gatatcaggc actgagccac tgcgcccagc caacaatccg     2820

ctctgaggaa agcgtaagca ggaagacctc ttaatggcat agcaccaata aaaaaatgac     2880

tcctagttgt gtttggaaag ggagagaaga gatgtctgag gaaggtcatg ttctttcagc     2940

ttatggcatt tcctagagtt ttgttgaagc aagaagaaaa actcagagaa tataaaatca     3000

acttttaaaa ttgtgtgctc tcttcttcac gtaggctcct gttaaaaaca aagtgcagtc     3060

agattctaag ccctgttcag agacttcgtg gatcacagct gcagctcacc gccacatcac     3120

aggatccgtt aacgttaata cccaatactc tgtcagccac tgtaggctct aagaaccacg     3180

tgcagtcttc agcccattaa attatcgatt attttttaat gaattgaatt tatattgagt     3240

cttcaaatta actgaatgga tttaaagggg taccaaggag gggggaaaca tcagaatttc     3300

ccaggcagtt gttgcaagga attggtacta accgtgacta caacaaaaat tcttgattga     3360

cttttaaagt tatttcctgg cattctggta ccttcaccca gcctgagtgc cctggagagg     3420

gaacaggaaa tgctgatctc tacccctggg tgagaccaga acctcagggc tgatactgtt     3480

gagtggcttc ctcggtttac tctgtgtact gtgaaagtat tttcatattt tttctgtgtg     3540

ccagagtgaa aaaggacagc ttctgagtgt ggtaattgtg cctctagcac ccagcctttc     3600

aaagcccacc tgaaacctgg gggtggatga aagaactaga atagaagact gaagctgggt     3660

aggccgctca gtgtccactg gcattttgct aaaccgacaa ggaaggctgt gtgcttagct     3720

ctccccagag ggagggcgag aagggtgtgg tgatggtcaa tctggctgtc ggaacagatt     3780

ctggtgtctt gggctgataa cagtgttgtt gattctgatt gtgaatcccc tcaactctag     3840

cagacacata cacacccctg aaatggggct gcagagcagg ctgtctcagc cttgccactg     3900

tcggcatctc ggcctgggta attctgttgt ggggactgtc ctgttccttg taggatgttt     3960

agtagcatcc ctgcccccac ctactagatg ccaggggcac tgttctcccc agccccccgc     4020

cccagttgtg acaatagtct ctaaacattg tcaaatggtc caaggaaagg ggaaaattgc     4080

cccggttgag aagagcactg ctgtaaagta atgagcctcg gctctcctgt ctgcacctgt     4140

ccggttacta cttggccacc acgcagcctt ggctcctaca gcccaaaagg gagaatggag     4200

ggaggctcca ggctttgctg gaggggcctg ggtgagttct gtttgctcct tgtaccacca     4260

tccaaatggt gttatcaaat ctcttagatt ccaaagaggt tgaataatta atgttcaaag     4320

gcaagagggc aaggcatttt ttaacacttt ttaaaataaa aatttatacc acaa           4374


<210>  4
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Ser Lys Leu Asn Asn Glu Glu His Asn Glu Leu Arg Glu Val 
1               5                   10                  15      


Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr Leu Tyr Tyr Met Ala Pro 
            20                  25                  30          


Glu His Leu Asn Asp Val Asn Ala Lys Pro Thr Glu Lys Ser Asp Val 
        35                  40                  45              


Tyr Ser Phe Ala Val Val Leu Trp Ala Ile Phe Ala Asn Lys Glu Pro 
    50                  55                  60                  


Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu Ile Met Cys Ile Lys Ser 
65                  70                  75                  80  


Gly Asn Arg Pro Asp Val Asp Asp Ile Thr Glu Tyr Cys Pro Arg Glu 
                85                  90                  95      


Ile Ile Ser Leu Met Lys Leu Cys Trp Glu Ala Asn Pro Glu Ala Arg 
            100                 105                 110         


Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe Arg Pro Phe Tyr Leu Ser 
        115                 120                 125             


Gln Leu Glu Glu Ser Val Glu Glu Asp Val Lys Ser Leu Lys Lys Glu 
    130                 135                 140                 


Tyr Ser Asn Glu Asn Ala Val Val Lys Arg Met Gln Ser Leu Gln Leu 
145                 150                 155                 160 


Asp Cys Val Ala Val Pro Ser Ser Arg Ser Asn Ser Ala Thr Glu Gln 
                165                 170                 175     


Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gly Met Gly Pro Val Glu 
            180                 185                 190         


Glu Ser Trp Phe Ala Pro Ser Leu Glu His Pro Gln Glu Glu Asn Glu 
        195                 200                 205             


Pro Ser Leu Gln Ser Lys Leu Gln Asp Glu Ala Asn Tyr His Leu Tyr 
    210                 215                 220                 


Gly Ser Arg Met Asp Arg Gln Thr Lys Gln Gln Pro Arg Gln Asn Val 
225                 230                 235                 240 


Ala Tyr Asn Arg Glu Glu Glu Arg Arg Arg Arg Val Ser His Asp Pro 
                245                 250                 255     


Phe Ala Gln Gln Arg Pro Tyr Glu Asn Phe Gln Asn Thr Glu Gly Lys 
            260                 265                 270         


Gly Thr Ala Tyr Ser Ser Ala Ala Ser His Gly Asn Ala Val His Gln 
        275                 280                 285             


Pro Ser Gly Leu Thr Ser Gln Pro Gln Val Leu Tyr Gln Asn Asn Gly 
    290                 295                 300                 


Leu Tyr Ser Ser His Gly Phe Gly Thr Arg Pro Leu Asp Pro Gly Thr 
305                 310                 315                 320 


Ala Gly Pro Arg Val Trp Tyr Arg Pro Ile Pro Ser His Met Pro Ser 
                325                 330                 335     


Leu His Asn Ile Pro Val Pro Glu Thr Asn Tyr Leu Gly Asn Thr Pro 
            340                 345                 350         


Thr Met Pro Phe Ser Ser Leu Pro Pro Thr Asp Glu Ser Ile Lys Tyr 
        355                 360                 365             


Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr Asn Tyr Met 
    370                 375                 380                 


Glu Ile Gly Gly Thr Ser Ser Ser Leu Leu Asp Ser Thr Asn Thr Asn 
385                 390                 395                 400 


Phe Lys Glu Glu Pro Ala Ala Lys Tyr Gln Ala Ile Phe Asp Asn Thr 
                405                 410                 415     


Thr Ser Leu Thr Asp Lys His Leu Asp Pro Ile Arg Glu Asn Leu Gly 
            420                 425                 430         


Lys His Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe Thr Gln Ser Gln 
        435                 440                 445             


Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly Leu Lys Glu Lys 
    450                 455                 460                 


Val Tyr Gln Met Leu Gln Lys Trp Val Met Arg Glu Gly Ile Lys Gly 
465                 470                 475                 480 


Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln Cys Ser Arg Ile 
                485                 490                 495     


Asp Leu Leu Ser Ser Leu Ile Tyr Val Ser Gln Asn 
            500                 505             


<210>  5
<211>  4512
<212>  DNA
<213>  Mus musculus

<400>  5
cgaaaagcgc ggaacttgct gtcatctagc gggaggttgg actcttcttg aggtcgtttt       60

agctcaagtc gagactgaag gacacagcac taagcaagaa ccaaaagtgg tgtgttggag      120

attctgagca atcaaaatgc aaccagacat gtccttggac aatattaaga tggcatccag      180

tgacctgctg gagaagacag acctagacag cggaggcttc gggaaggtgt ccttgtgtta      240

ccacagaagc catggatttg tcatcctgaa aaaagtatac acagggccca accgcgctga      300

gtacaatgag gttctcttgg aagaggggaa gatgatgcac agactgagac acagtcgagt      360

ggtgaagcta ctgggcatca tcatagaaga agggaactat tcgctggtga tggagtacat      420

ggagaagggc aacctgatgc acgtgctaaa gacccagata gatgtcccac tttcattgaa      480

aggaaggata atcgtggagg ccatagaagg catgtgctac ttacatgaca aaggtgtgat      540

acacaaggac ctgaagcctg agaatatcct cgttgatcgt gactttcaca ttaagatagc      600

cgatcttggt gtggcttcct ttaagacatg gagcaaactg actaaggaga aagacaacaa      660

gcagaaagaa gtgagcagca ccactaagaa gaacaatggt ggtacccttt actacatggc      720

acccgaacac ctgaatgaca tcaatgcaaa gcccacggag aagtcggacg tgtacagctt      780

tggcattgtc ctttgggcaa tatttgcaaa aaaggagccc tatgagaatg tcatctgtac      840

tgagcagttc gtgatctgca taaaatctgg gaacaggcca aatgtagagg aaatccttga      900

gtactgtcca agggagatca tcagcctcat ggagcggtgc tggcaggcga tcccagaaga      960

caggccaaca tttcttggca ttgaagaaga atttaggcct ttttacttaa gtcattttga     1020

agaatatgta gaagaggatg tggcaagttt aaagaaagag tatccagatc aaagcccagt     1080

gctgcagaga atgttttcac tgcagcatga ctgtgtaccc ttacctccga gcaggtcaaa     1140

ttcagaacaa cctggatcgc tgcacagttc ccaggggctc cagatgggtc ctgtggagga     1200

gtcctggttt tcttcctccc cagagtaccc acaggacgag aatgatcgca gtgtgcaggc     1260

taagctgcaa gaggaagcca gctatcatgc ttttggaata tttgcagaga aacagacaaa     1320

accgcagcca aggcagaatg aggcttacaa cagagaggag gaaaggaaac gaagggtctc     1380

tcatgacccc tttgcacagc agagagctcg tgagaatatt aagagtgcag gagcaagagg     1440

tcattctgat cccagcacaa cgagtcgtgg aattgcagtg caacagctgt catggccagc     1500

cacccaaaca gtttggaaca atggattgta taatcagcat ggatttggaa ctacaggtac     1560

aggagtttgg tatccgccaa atctaagcca aatgtatagt acttataaaa ctccagtgcc     1620

agagaccaac ataccgggaa gcacacccac catgccatac ttctctgggc cagtagcaga     1680

tgacctcata aaatatacta tattcaatag ttctggtatt cagattggaa accacaatta     1740

tatggatgtt ggactgaatt cacaaccacc aaacaatact tgcaaagaag agtcgacttc     1800

cagacaccaa gccatctttg ataacaccac tagtctgact gatgaacacc tgaaccctat     1860

cagggaaaac ctgggaaggc agtggaaaaa ctgtgcccgc aagctgggct tcactgagtc     1920

tcagatcgat gaaatcgacc atgactatga aagagatgga ctgaaagaga aagtttacca     1980

aatgcttcag aagtggctga tgcgggaagg caccaaaggg gccacagtgg gaaagttggc     2040

ccaggcactt caccaatgtt gcaggataga cctgctgaac cacttgattc gtgccagcca     2100

gagctaagcc tgggcaggct ctggcagtgg gaagcaaact atttgtctgg tgcacaaacc     2160

ccgtttgccc actagccttc agaactctat ctcagcatga gctctgcatt tgagcacaca     2220

gggtcatgca gtttggaact ggtggatggg aagagaaatc tgaagcccac agtgattctt     2280

cagaacatgc aagcataaag accgctgaat gaatggtcgg tccatgacca gtaggaggaa     2340

aaaaattaaa aatacagtgt attgagtttt caaagggaga gaagatgttg ggggaaggtg     2400

gccttcgttc agcttgtgtc atagtcatca cttaggttat ttgctcagtt tcctgtggtt     2460

tcattgggta aggggaaaac aaacaaaaaa cattcaaaga atgtaaaatc agctagcttc     2520

ccgcttcatg gactgtgagt cagaaaagtt ctgctcaaat gccttctatg agccacggct     2580

cttctaaaaa ctataggatc tgttaacttg agcatccaat gctgtactgt caccttaagc     2640

tttaagaatc atgtgtaatt ctagtctatc aaattatcaa ttagtgagag atttttaagg     2700

agtgctaagg agaaaaaggt gcagggcaga gagagatctt caggtactgg ctgtcattgc     2760

agctcaggta ctggctgtca ttgcagagct gctgctggtt ctggctgctg taaaaagtct     2820

acttttaagt ttctaaagtt tctctaccat tctggcgctt catgcagttt cccaccctgt     2880

gagccccaca gagggaacag atgtgcagga aacactgatc gggaaatacc atctcctcct     2940

ctctggatat gactggtgcc ttagcactgt tccctgtgcc caataaactg tttcctcagt     3000

tttctccagt gtgctgtaca aatatgtttc ttctgtgtgc caccaatcaa gaaaggacag     3060

cttcagagtc atcttgtgcc tttaggaagc ccatattgca acctacaagt gagtgaagga     3120

gctagggtag aagactgaag ccgcctacac cagccacagt cactgttagg atgggctgca     3180

cagccgcttt ggccttgttg gccattctgg cactcattgg cacttcatcc tcctttgttg     3240

ggctatcctg tactcagtag gatatttggg aacattcctg gcctccatct gcaagatgcc     3300

aacagtacaa gtcaacctca caacacccac caggtgtgag aaaaataact agatattgct     3360

acatgttctt tggagggact ctcctgtaac gttatttccc ccatccccag acaaggtttc     3420

tcagttctcg ctgtcctgga actcactttg tagaccagat tggtctccca attcagagat     3480

ctgcctgcct ctgcctcctg agtgctggga ataaaggcat gtgccaccac cacccagctt     3540

cctgctgtaa gtttatatgc cttacttctc ctgtcacaca ggctaggcca tcattaacag     3600

catggaacat gcacagtgga agggaattgg agcagggaag gttccaggct ttcctgaagg     3660

agcctgcata gtctttaaaa aatgttttct ttttaacttc taatgctgtt ttaagaagac     3720

agaattagaa actgcttcta gtggagtttt aaggagaata aaatagcaag ggaggccaga     3780

gctggttttg gaattgcagt agcaatcagg gtcctagtat taaaatcatg tctgttagtg     3840

ttcagtaggg gaagacttgt gtgtccactg ctgaagatag gtgcttcaga tccaggcctg     3900

gattgtgacc acagactttc agatcttttc caggctcacc actgacagcc agacaatggc     3960

ttggcacctc gagttgtggc tgagcctgta tgagttgaag gatggtcagt agatgaagcc     4020

gtttactctc atggtgtgtg cccttgtaca agagatctgg gcgcgtgaca caaagccagt     4080

cattgacagg ctagacccaa agacctttaa gcactcccat ttgcttccgc tgtatcacaa     4140

taactgatga ctttgtagtc agtggtacct gctccgaaca agtacgtgga gtgtgggagt     4200

ccctctggga gcccagcgtg gaattagaac acctctttaa agccacctcc taagccgagc     4260

agaatgcagt ggactggggt acaagtcaga cctgagtgtc attgtccaca tcatggaaaa     4320

acaagatggc caccagaaca ctgaaggcct gaggagacta accctgttcc cagaactcag     4380

agttctgttt ggttctgttt ttaataagat aacctttctt taatgtatac atatgcatat     4440

acatatatat ttgtacttta aatacagagt actgaataaa atttatgtga ctataaaaaa     4500

aaaaaaaaaa aa                                                         4512


<210>  6
<211>  656
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gln Pro Asp Met Ser Leu Asp Asn Ile Lys Met Ala Ser Ser Asp 
1               5                   10                  15      


Leu Leu Glu Lys Thr Asp Leu Asp Ser Gly Gly Phe Gly Lys Val Ser 
            20                  25                  30          


Leu Cys Tyr His Arg Ser His Gly Phe Val Ile Leu Lys Lys Val Tyr 
        35                  40                  45              


Thr Gly Pro Asn Arg Ala Glu Tyr Asn Glu Val Leu Leu Glu Glu Gly 
    50                  55                  60                  


Lys Met Met His Arg Leu Arg His Ser Arg Val Val Lys Leu Leu Gly 
65                  70                  75                  80  


Ile Ile Ile Glu Glu Gly Asn Tyr Ser Leu Val Met Glu Tyr Met Glu 
                85                  90                  95      


Lys Gly Asn Leu Met His Val Leu Lys Thr Gln Ile Asp Val Pro Leu 
            100                 105                 110         


Ser Leu Lys Gly Arg Ile Ile Val Glu Ala Ile Glu Gly Met Cys Tyr 
        115                 120                 125             


Leu His Asp Lys Gly Val Ile His Lys Asp Leu Lys Pro Glu Asn Ile 
    130                 135                 140                 


Leu Val Asp Arg Asp Phe His Ile Lys Ile Ala Asp Leu Gly Val Ala 
145                 150                 155                 160 


Ser Phe Lys Thr Trp Ser Lys Leu Thr Lys Glu Lys Asp Asn Lys Gln 
                165                 170                 175     


Lys Glu Val Ser Ser Thr Thr Lys Lys Asn Asn Gly Gly Thr Leu Tyr 
            180                 185                 190         


Tyr Met Ala Pro Glu His Leu Asn Asp Ile Asn Ala Lys Pro Thr Glu 
        195                 200                 205             


Lys Ser Asp Val Tyr Ser Phe Gly Ile Val Leu Trp Ala Ile Phe Ala 
    210                 215                 220                 


Lys Lys Glu Pro Tyr Glu Asn Val Ile Cys Thr Glu Gln Phe Val Ile 
225                 230                 235                 240 


Cys Ile Lys Ser Gly Asn Arg Pro Asn Val Glu Glu Ile Leu Glu Tyr 
                245                 250                 255     


Cys Pro Arg Glu Ile Ile Ser Leu Met Glu Arg Cys Trp Gln Ala Ile 
            260                 265                 270         


Pro Glu Asp Arg Pro Thr Phe Leu Gly Ile Glu Glu Glu Phe Arg Pro 
        275                 280                 285             


Phe Tyr Leu Ser His Phe Glu Glu Tyr Val Glu Glu Asp Val Ala Ser 
    290                 295                 300                 


Leu Lys Lys Glu Tyr Pro Asp Gln Ser Pro Val Leu Gln Arg Met Phe 
305                 310                 315                 320 


Ser Leu Gln His Asp Cys Val Pro Leu Pro Pro Ser Arg Ser Asn Ser 
                325                 330                 335     


Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gln Met Gly Pro 
            340                 345                 350         


Val Glu Glu Ser Trp Phe Ser Ser Ser Pro Glu Tyr Pro Gln Asp Glu 
        355                 360                 365             


Asn Asp Arg Ser Val Gln Ala Lys Leu Gln Glu Glu Ala Ser Tyr His 
    370                 375                 380                 


Ala Phe Gly Ile Phe Ala Glu Lys Gln Thr Lys Pro Gln Pro Arg Gln 
385                 390                 395                 400 


Asn Glu Ala Tyr Asn Arg Glu Glu Glu Arg Lys Arg Arg Val Ser His 
                405                 410                 415     


Asp Pro Phe Ala Gln Gln Arg Ala Arg Glu Asn Ile Lys Ser Ala Gly 
            420                 425                 430         


Ala Arg Gly His Ser Asp Pro Ser Thr Thr Ser Arg Gly Ile Ala Val 
        435                 440                 445             


Gln Gln Leu Ser Trp Pro Ala Thr Gln Thr Val Trp Asn Asn Gly Leu 
    450                 455                 460                 


Tyr Asn Gln His Gly Phe Gly Thr Thr Gly Thr Gly Val Trp Tyr Pro 
465                 470                 475                 480 


Pro Asn Leu Ser Gln Met Tyr Ser Thr Tyr Lys Thr Pro Val Pro Glu 
                485                 490                 495     


Thr Asn Ile Pro Gly Ser Thr Pro Thr Met Pro Tyr Phe Ser Gly Pro 
            500                 505                 510         


Val Ala Asp Asp Leu Ile Lys Tyr Thr Ile Phe Asn Ser Ser Gly Ile 
        515                 520                 525             


Gln Ile Gly Asn His Asn Tyr Met Asp Val Gly Leu Asn Ser Gln Pro 
    530                 535                 540                 


Pro Asn Asn Thr Cys Lys Glu Glu Ser Thr Ser Arg His Gln Ala Ile 
545                 550                 555                 560 


Phe Asp Asn Thr Thr Ser Leu Thr Asp Glu His Leu Asn Pro Ile Arg 
                565                 570                 575     


Glu Asn Leu Gly Arg Gln Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe 
            580                 585                 590         


Thr Glu Ser Gln Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly 
        595                 600                 605             


Leu Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp Leu Met Arg Glu 
    610                 615                 620                 


Gly Thr Lys Gly Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln 
625                 630                 635                 640 


Cys Cys Arg Ile Asp Leu Leu Asn His Leu Ile Arg Ala Ser Gln Ser 
                645                 650                 655     


<210>  7
<211>  3813
<212>  DNA
<213>  Homo sapiens

<400>  7
aacgctggtc ctcggccggg cgcgctgacg tcatcgtgcg tcagagtgag cccggatggg       60

gcggcgggct tcgggagcgc ccgggctgat ccgagccgag cgggccgtat ctccttgtcg      120

gcgccgctga ttcccggctc tgcggaggcc tctaggcagc cgcgcagctt ccgtgtttgc      180

tgcgcccgca ctgcgattta caaccctgaa gaatctccct atccctattt tgtccccctg      240

cagtaataaa tcccattatg gagatctcga aactttataa agggatatag tttgaattct      300

atggagtgta attttgtgta tgaattatat ttttaaaaca ttgaagagtt ttcagaaaga      360

aggctagtag agttgattac tgatacttta tgctaagcag tacttttttg gtagtacaat      420

attttgttag gcgtttctga taacactaga aaggacaagt tttatcttgt gataaattga      480

ttaatgttta caacatgact gataattata gctgaatagt ccttaaatga tgaacaggtt      540

atttagtttt taaatgcagt gtaaaaagtg tgctgtggaa attttatggc taactaagtt      600

tatggagaaa ataccttcag ttgatcaaga ataatagtgg tatacaaagt taggaagaaa      660

gtcaacatga tgctgcagga aatggaaaca aatacaaatg atatttaaca aagatagagt      720

ttacagtttt tgaactttaa gccaaattca tttgacatca agcactatag caggcacagg      780

ttcaacaaag cttgtgggta ttgacttccc ccaaaagttg tcagctgaag taatttagcc      840

cacttaagta aatactatga tgataagctg tgtgaactta gcttttaaat agtgtgacca      900

tatgaaggtt ttaattactt ttgtttattg gaataaaatg agattttttg ggttgtcatg      960

ttaaagtgct tatagggaaa gaagcctgca tataattttt taccttgtgg cataatcagt     1020

aattggtctg ttattcaggc ttcatagctt gtaaccaaat ataaataaaa ggcataattt     1080

aggtattcta tagttgctta gaattttgtt aatataaatc tctgtgaaaa atcaaggagt     1140

tttaatattt tcagaagtgc atccaccttt cagggcttta agttagtatt actcaagatt     1200

atgaacaaat agcacttagg ttacctgaaa gagttactac aaccccaaag agttgtgttc     1260

taagtagtat cttggtaatt cagagagata ctcatcctac ctgaatataa actgagataa     1320

atccagtaaa gaaagtgtag taaattctac ataagagtct atcattgatt tctttttgtg     1380

gtaaaaatct tagttcatgt gaagaaattt catgtgaatg ttttagctat caaacagtac     1440

tgtcacctac tcatgcacaa aactgcctcc caaagacttt tcccaggtcc ctcgtatcaa     1500

aacattaaga gtataatgga agatagcacg atcttgtcag attggacaaa cagcaacaaa     1560

caaaaaatga agtatgactt ttcctgtgaa ctctacagaa tgtctacata ttcaactttc     1620

cccgccgggg tgcctgtctc agaaaggagt cttgctcgtg ctggttttta ttatactggt     1680

gtgaatgaca aggtcaaatg cttctgttgt ggcctgatgc tggataactg gaaactagga     1740

gacagtccta ttcaaaagca taaacagcta tatcctagct gtagctttat tcagaatctg     1800

gtttcagcta gtctgggatc cacctctaag aatacgtctc caatgagaaa cagttttgca     1860

cattcattat ctcccacctt ggaacatagt agcttgttca gtggttctta ctccagcctt     1920

tctccaaacc ctcttaattc tagagcagtt gaagacatct cttcatcgag gactaacccc     1980

tacagttatg caatgagtac tgaagaagcc agatttctta cctaccatat gtggccatta     2040

acttttttgt caccatcaga attggcaaga gctggttttt attatatagg acctggagat     2100

agggtagcct gctttgcctg tggtgggaag ctcagtaact gggaaccaaa ggatgatgct     2160

atgtcagaac accggaggca ttttcccaac tgtccatttt tggaaaattc tctagaaact     2220

ctgaggttta gcatttcaaa tctgagcatg cagacacatg cagctcgaat gagaacattt     2280

atgtactggc catctagtgt tccagttcag cctgagcagc ttgcaagtgc tggtttttat     2340

tatgtgggtc gcaatgatga tgtcaaatgc ttttgttgtg atggtggctt gaggtgttgg     2400

gaatctggag atgatccatg ggtagaacat gccaagtggt ttccaaggtg tgagttcttg     2460

atacgaatga aaggccaaga gtttgttgat gagattcaag gtagatatcc tcatcttctt     2520

gaacagctgt tgtcaacttc agataccact ggagaagaaa atgctgaccc accaattatt     2580

cattttggac ctggagaaag ttcttcagaa gatgctgtca tgatgaatac acctgtggtt     2640

aaatctgcct tggaaatggg ctttaataga gacctggtga aacaaacagt tcaaagtaaa     2700

atcctgacaa ctggagagaa ctataaaaca gttaatgata ttgtgtcagc acttcttaat     2760

gctgaagatg aaaaaagaga agaggagaag gaaaaacaag ctgaagaaat ggcatcagat     2820

gatttgtcat taattcggaa gaacagaatg gctctctttc aacaattgac atgtgtgctt     2880

cctatcctgg ataatctttt aaaggccaat gtaattaata aacaggaaca tgatattatt     2940

aaacaaaaaa cacagatacc tttacaagcg agagaactga ttgataccat tttggttaaa     3000

ggaaatgctg cggccaacat cttcaaaaac tgtctaaaag aaattgactc tacattgtat     3060

aagaacttat ttgtggataa gaatatgaag tatattccaa cagaagatgt ttcaggtctg     3120

tcactggaag aacaattgag gaggttgcaa gaagaacgaa cttgtaaagt gtgtatggac     3180

aaagaagttt ctgttgtatt tattccttgt ggtcatctgg tagtatgcca ggaatgtgcc     3240

ccttctctaa gaaaatgccc tatttgcagg ggtataatca agggtactgt tcgtacattt     3300

ctctcttaaa gaaaaatagt ctatatttta acctgcataa aaaggtcttt aaaatattgt     3360

tgaacacttg aagccatcta aagtaaaaag ggaattatga gtttttcaat tagtaacatt     3420

catgttctag tctgctttgg tactaataat cttgtttctg aaaagatggt atcatatatt     3480

taatcttaat ctgtttattt acaagggaag atttatgttt ggtgaactat attagtatgt     3540

atgtgtacct aagggagtag tgtcactgct tgttatgcat catttcagga gttactggat     3600

ttgttgttct ttcagaaagc tttgaatact aaattatagt gtagaaaaga actggaaacc     3660

aggaactctg gagttcatca gagttatggt gccgaattgt ctttggtgct tttcacttgt     3720

gttttaaaat aaggattttt ctcttatttc tccccctagt ttgtgagaaa catctcaata     3780

aagtgcttta aaaagaaaaa aaaaaaaaaa aaa                                  3813


<210>  8
<211>  4088
<212>  DNA
<213>  Homo sapiens

<400>  8
gcggtgagtg ctgctccttc cgggctcggg cggcgtgggg cgggtgggga cgcgagggcc       60

cgcgggggcc cacttccctg atgtggcggc gaacgaggaa ggacggggcc tgaggccctt      120

cggccaaggg tcgagggtcg ccgggggctc tctgctttct actctcgcca aggttttatt      180

ggattcggaa gccccaactt cgagacttgc agtcaaagcg atttttaaaa tgacttgttt      240

tcaagcctct ggccgccgcc cactcttctg gcccttggac tttgaccaag atgttttctc      300

gcagtttttg caaggtttta aacttagccc tcggcgttct tttaatgtaa tacattgaaa      360

cgaagatatt tcggtggcgg cgatatttca tatttcatag ttgccactgc gctctgtcat      420

tccagtagtc gtctgttgtg tattgtgaga agcaactctg ggaaattatt ggatttacaa      480

ccctgaagaa tctccctatc cctattttgt ccccctgcag taataaatcc cattatggag      540

atctcgaaac tttataaagg gatatagttt gaattctatg gagtgtaatt ttgtgtatga      600

attatatttt taaaacattg aagagttttc agaaagaagg ctagtagagt tgattactga      660

tactttatgc taagcagtac ttttttggta gtacaatatt ttgttaggcg tttctgataa      720

cactagaaag gacaagtttt atcttgtgat aaattgatta atgtttacaa catgactgat      780

aattatagct gaatagtcct taaatgatga acaggttatt tagtttttaa atgcagtgta      840

aaaagtgtgc tgtggaaatt ttatggctaa ctaagtttat ggagaaaata ccttcagttg      900

atcaagaata atagtggtat acaaagttag gaagaaagtc aacatgatgc tgcaggaaat      960

ggaaacaaat acaaatgata tttaacaaag atagagttta cagtttttga actttaagcc     1020

aaattcattt gacatcaagc actatagcag gcacaggttc aacaaagctt gtgggtattg     1080

acttccccca aaagttgtca gctgaagtaa tttagcccac ttaagtaaat actatgatga     1140

taagctgtgt gaacttagct tttaaatagt gtgaccatat gaaggtttta attacttttg     1200

tttattggaa taaaatgaga ttttttgggt tgtcatgtta aagtgcttat agggaaagaa     1260

gcctgcatat aattttttac cttgtggcat aatcagtaat tggtctgtta ttcaggcttc     1320

atagcttgta accaaatata aataaaaggc ataatttagg tattctatag ttgcttagaa     1380

ttttgttaat ataaatctct gtgaaaaatc aaggagtttt aatattttca gaagtgcatc     1440

cacctttcag ggctttaagt tagtattact caagattatg aacaaatagc acttaggtta     1500

cctgaaagag ttactacaac cccaaagagt tgtgttctaa gtagtatctt ggtaattcag     1560

agagatactc atcctacctg aatataaact gagataaatc cagtaaagaa agtgtagtaa     1620

attctacata agagtctatc attgatttct ttttgtggta aaaatcttag ttcatgtgaa     1680

gaaatttcat gtgaatgttt tagctatcaa acagtactgt cacctactca tgcacaaaac     1740

tgcctcccaa agacttttcc caggtccctc gtatcaaaac attaagagta taatggaaga     1800

tagcacgatc ttgtcagatt ggacaaacag caacaaacaa aaaatgaagt atgacttttc     1860

ctgtgaactc tacagaatgt ctacatattc aactttcccc gccggggtgc ctgtctcaga     1920

aaggagtctt gctcgtgctg gtttttatta tactggtgtg aatgacaagg tcaaatgctt     1980

ctgttgtggc ctgatgctgg ataactggaa actaggagac agtcctattc aaaagcataa     2040

acagctatat cctagctgta gctttattca gaatctggtt tcagctagtc tgggatccac     2100

ctctaagaat acgtctccaa tgagaaacag ttttgcacat tcattatctc ccaccttgga     2160

acatagtagc ttgttcagtg gttcttactc cagcctttct ccaaaccctc ttaattctag     2220

agcagttgaa gacatctctt catcgaggac taacccctac agttatgcaa tgagtactga     2280

agaagccaga tttcttacct accatatgtg gccattaact tttttgtcac catcagaatt     2340

ggcaagagct ggtttttatt atataggacc tggagatagg gtagcctgct ttgcctgtgg     2400

tgggaagctc agtaactggg aaccaaagga tgatgctatg tcagaacacc ggaggcattt     2460

tcccaactgt ccatttttgg aaaattctct agaaactctg aggtttagca tttcaaatct     2520

gagcatgcag acacatgcag ctcgaatgag aacatttatg tactggccat ctagtgttcc     2580

agttcagcct gagcagcttg caagtgctgg tttttattat gtgggtcgca atgatgatgt     2640

caaatgcttt tgttgtgatg gtggcttgag gtgttgggaa tctggagatg atccatgggt     2700

agaacatgcc aagtggtttc caaggtgtga gttcttgata cgaatgaaag gccaagagtt     2760

tgttgatgag attcaaggta gatatcctca tcttcttgaa cagctgttgt caacttcaga     2820

taccactgga gaagaaaatg ctgacccacc aattattcat tttggacctg gagaaagttc     2880

ttcagaagat gctgtcatga tgaatacacc tgtggttaaa tctgccttgg aaatgggctt     2940

taatagagac ctggtgaaac aaacagttca aagtaaaatc ctgacaactg gagagaacta     3000

taaaacagtt aatgatattg tgtcagcact tcttaatgct gaagatgaaa aaagagaaga     3060

ggagaaggaa aaacaagctg aagaaatggc atcagatgat ttgtcattaa ttcggaagaa     3120

cagaatggct ctctttcaac aattgacatg tgtgcttcct atcctggata atcttttaaa     3180

ggccaatgta attaataaac aggaacatga tattattaaa caaaaaacac agataccttt     3240

acaagcgaga gaactgattg ataccatttt ggttaaagga aatgctgcgg ccaacatctt     3300

caaaaactgt ctaaaagaaa ttgactctac attgtataag aacttatttg tggataagaa     3360

tatgaagtat attccaacag aagatgtttc aggtctgtca ctggaagaac aattgaggag     3420

gttgcaagaa gaacgaactt gtaaagtgtg tatggacaaa gaagtttctg ttgtatttat     3480

tccttgtggt catctggtag tatgccagga atgtgcccct tctctaagaa aatgccctat     3540

ttgcaggggt ataatcaagg gtactgttcg tacatttctc tcttaaagaa aaatagtcta     3600

tattttaacc tgcataaaaa ggtctttaaa atattgttga acacttgaag ccatctaaag     3660

taaaaaggga attatgagtt tttcaattag taacattcat gttctagtct gctttggtac     3720

taataatctt gtttctgaaa agatggtatc atatatttaa tcttaatctg tttatttaca     3780

agggaagatt tatgtttggt gaactatatt agtatgtatg tgtacctaag ggagtagtgt     3840

cactgcttgt tatgcatcat ttcaggagtt actggatttg ttgttctttc agaaagcttt     3900

gaatactaaa ttatagtgta gaaaagaact ggaaaccagg aactctggag ttcatcagag     3960

ttatggtgcc gaattgtctt tggtgctttt cacttgtgtt ttaaaataag gatttttctc     4020

ttatttctcc ccctagtttg tgagaaacat ctcaataaag tgctttaaaa agaaaaaaaa     4080

aaaaaaaa                                                              4088


<210>  9
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  10
<211>  2408
<212>  DNA
<213>  Homo sapiens

<400>  10
aacgctggtc ctcggccggg cgcgctgacg tcatcgtgcg tcagagtgag cccggatggg       60

gcggcgggct tcgggagcgc ccgggctgat ccgagccgag cgggccgtat ctccttgtcg      120

gcgccgctga ttcccggctc tgcggaggcc tctaggcagc cgcgcagctt ccgtgtttgc      180

tgcgcccgca ctgcgaatgt ctacatattc aactttcccc gccggggtgc ctgtctcaga      240

aaggagtctt gctcgtgctg gtttttatta tactggtgtg aatgacaagg tcaaatgctt      300

ctgttgtggc ctgatgctgg ataactggaa actaggagac agtcctattc aaaagcataa      360

acagctatat cctagctgta gctttattca gaatctggtt tcagctagtc tgggatccac      420

ctctaagaat acgtctccaa tgagaaacag ttttgcacat tcattatctc ccaccttgga      480

acatagtagc ttgttcagtg gttcttactc cagcctttct ccaaaccctc ttaattctag      540

agcagttgaa gacatctctt catcgaggac taacccctac agttatgcaa tgagtactga      600

agaagccaga tttcttacct accatatgtg gccattaact tttttgtcac catcagaatt      660

ggcaagagct ggtttttatt atataggacc tggagatagg gtagcctgct ttgcctgtgg      720

tgggaagctc agtaactggg aaccaaagga tgatgctatg tcagaacacc ggaggcattt      780

tcccaactgt ccatttttgg aaaattctct agaaactctg aggtttagca tttcaaatct      840

gagcatgcag acacatgcag ctcgaatgag aacatttatg tactggccat ctagtgttcc      900

agttcagcct gagcagcttg caagtgctgg tttttattat gtgggtcgca atgatgatgt      960

caaatgcttt tgttgtgatg gtggcttgag gtgttgggaa tctggagatg atccatgggt     1020

agaacatgcc aagtggtttc caaggtgtga gttcttgata cgaatgaaag gccaagagtt     1080

tgttgatgag attcaaggta gatatcctca tcttcttgaa cagctgttgt caacttcaga     1140

taccactgga gaagaaaatg ctgacccacc aattattcat tttggacctg gagaaagttc     1200

ttcagaagat gctgtcatga tgaatacacc tgtggttaaa tctgccttgg aaatgggctt     1260

taatagagac ctggtgaaac aaacagttca aagtaaaatc ctgacaactg gagagaacta     1320

taaaacagtt aatgatattg tgtcagcact tcttaatgct gaagatgaaa aaagagaaga     1380

ggagaaggaa aaacaagctg aagaaatggc atcagatgat ttgtcattaa ttcggaagaa     1440

cagaatggct ctctttcaac aattgacatg tgtgcttcct atcctggata atcttttaaa     1500

ggccaatgta attaataaac aggaacatga tattattaaa caaaaaacac agataccttt     1560

acaagcgaga gaactgattg ataccatttt ggttaaagga aatgctgcgg ccaacatctt     1620

caaaaactgt ctaaaagaaa ttgactctac attgtataag aacttatttg tggataagaa     1680

tatgaagtat attccaacag aagatgtttc aggtctgtca ctggaagaac aattgaggag     1740

gttgcaagaa gaacgaactt gtaaagtgtg tatggacaaa gaagtttctg ttgtatttat     1800

tccttgtggt catctggtag tatgccagga atgtgcccct tctctaagaa aatgccctat     1860

ttgcaggggt ataatcaagg gtactgttcg tacatttctc tcttaaagaa aaatagtcta     1920

tattttaacc tgcataaaaa ggtctttaaa atattgttga acacttgaag ccatctaaag     1980

taaaaaggga attatgagtt tttcaattag taacattcat gttctagtct gctttggtac     2040

taataatctt gtttctgaaa agatggtatc atatatttaa tcttaatctg tttatttaca     2100

agggaagatt tatgtttggt gaactatatt agtatgtatg tgtacctaag ggagtagtgt     2160

cactgcttgt tatgcatcat ttcaggagtt actggatttg ttgttctttc agaaagcttt     2220

gaatactaaa ttatagtgta gaaaagaact ggaaaccagg aactctggag ttcatcagag     2280

ttatggtgcc gaattgtctt tggtgctttt cacttgtgtt ttaaaataag gatttttctc     2340

ttatttctcc ccctagtttg tgagaaacat ctcaataaag tgctttaaaa agaaaaaaaa     2400

aaaaaaaa                                                              2408


<210>  11
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
1               5                   10                  15      


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
            20                  25                  30          


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly Asp 
        35                  40                  45              


Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe Ile 
    50                  55                  60                  


Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr Ser 
65                  70                  75                  80  


Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu His 
                85                  90                  95      


Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro Leu 
            100                 105                 110         


Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro Tyr 
        115                 120                 125             


Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His Met 
    130                 135                 140                 


Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly Phe 
145                 150                 155                 160 


Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly Gly 
                165                 170                 175     


Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His Arg 
            180                 185                 190         


Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr Leu 
        195                 200                 205             


Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg Met 
    210                 215                 220                 


Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val Lys 
                245                 250                 255     


Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp Asp 
            260                 265                 270         


Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu Ile 
        275                 280                 285             


Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr Pro 
    290                 295                 300                 


His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu Glu 
305                 310                 315                 320 


Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser Ser 
                325                 330                 335     


Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu Glu 
            340                 345                 350         


Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys Ile 
        355                 360                 365             


Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser Ala 
    370                 375                 380                 


Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys Gln 
385                 390                 395                 400 


Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn Arg 
                405                 410                 415     


Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn 
            420                 425                 430         


Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys 
        435                 440                 445             


Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr Ile 
    450                 455                 460                 


Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys 
465                 470                 475                 480 


Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn Met 
                485                 490                 495     


Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln 
            500                 505                 510         


Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp Lys 
        515                 520                 525             


Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys Gln 
    530                 535                 540                 


Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile Ile 
545                 550                 555                 560 


Lys Gly Thr Val Arg Thr Phe Leu Ser 
                565                 


<210>  12
<211>  3333
<212>  DNA
<213>  Mus musculus

<400>  12
ttttgggaag gctgcggatc aacaatcagg cgcctctgct tccagggcgc cgggggcctg       60

actcggtgat tgatagtcct caagagtctt catgttctct tatgtttttc tagaaatcag      120

cccactcatg gacatctgaa catttctata agacgctgcg gtttgctttg cagtgtgttc      180

ttgtgtatga ttagttatat aaaatacgaa gttttcaaaa agaaggctag tgcaacagaa      240

aagctttgct aaaacagatt cttagttatt tgaggtaaca aaagaaagcc atgtcttgaa      300

ttgattcgtt cttaattata acagacttat agtggaaagg gccttaaaca caggcggact      360

ttataaaatg cagtcttagg tttatgtgca aaatactgtc tgttgaccag atgtattcac      420

atgatatata cagagtcaag gtggtgatat agaagattta acagtgaggg agttaacagt      480

ctgtgcttta agcgcagttc ctttacagtg aatactgtag tcttaataga cctgagctga      540

ctgctgcagt tgatgtaacc cactttagag aatactgtat gacatcttct ctaaggaaaa      600

ccagctgcag acttcactca gttcctttca tttcatagga aaaggagtag ttcagatgtc      660

atgtttaagt ccttataagg gaaaagagcc tgaatatatg ccctagtacc taggcttcat      720

aactagtaat aagaagttag ttatgggtaa atagatctca ggttacccag aagagttcat      780

gtgaccccca aagagtccta actagtgtct tggcaagtga gacagatttg tcctgtgagg      840

gtgtcaattc accagtccaa gcagaagaca atgaatctat ccagtcaggt gtctgtggtg      900

gagatctagt gtcaagtggt gagaaacttc atctggaagt ttaagcggtc agaaatacta      960

ttactactca tggacaaaac tgtctcccag agactcggcc aaggtacctt acaccaaaaa     1020

cttaaacgta taatggagaa gagcacaatc ttgtcaaatt ggacaaagga gagcgaagaa     1080

aaaatgaagt ttgacttttc gtgtgaactc taccgaatgt ctacatattc agcttttccc     1140

aggggagttc ctgtctcaga gaggagtctg gctcgtgctg gcttttatta tacaggtgtg     1200

aatgacaaag tcaagtgctt ctgctgtggc ctgatgttgg ataactggaa acaaggggac     1260

agtcctgttg aaaagcacag acagttctat cccagctgca gctttgtaca gactctgctt     1320

tcagccagtc tgcagtctcc atctaagaat atgtctcctg tgaaaagtag atttgcacat     1380

tcgtcacctc tggaacgagg tggcattcac tccaacctgt gctctagccc tcttaattct     1440

agagcagtgg aagacttctc atcaaggatg gatccctgca gctatgccat gagtacagaa     1500

gaggccagat ttcttactta cagtatgtgg cctttaagtt ttctgtcacc agcagagctg     1560

gccagagctg gcttctatta catagggcct ggagacaggg tggcctgttt tgcctgtggt     1620

gggaaactga gcaactggga accaaaggat gatgctatgt cagagcaccg cagacatttt     1680

ccccactgtc catttctgga aaatacttca gaaacacaga ggtttagtat atcaaatcta     1740

agtatgcaga cacactctgc tcgattgagg acatttctgt actggccacc tagtgttcct     1800

gttcagcccg agcagcttgc aagtgctgga ttctattacg tggatcgcaa tgatgatgtc     1860

aagtgctttt gttgtgatgg tggcttgaga tgttgggaac ctggagatga cccctggata     1920

gaacacgcca aatggtttcc aaggtgtgag ttcttgatac ggatgaaggg tcaggagttt     1980

gttgatgaga ttcaagctag atatcctcat cttcttgagc agctgttgtc cacttcagac     2040

accccaggag aagaaaatgc tgaccctaca gagacagtgg tgcattttgg ccctggagaa     2100

agttcggaag atgtcgtcat gatgagcacg cctgtggtta aagcagcctt ggaaatgggc     2160

ttcagtagga gcctggtgag acagacggtt cagcggcaga tcctggccac tggtgagaac     2220

tacaggaccg tcaatgatat tgtctcagta cttttgaatg ctgaagatga gagaagagaa     2280

gaggagaagg aaagacagac tgaagagatg gcatcaggtg acttatcact gattcggaag     2340

aatagaatgg ccctctttca acagttgaca catgtccttc ctatcctgga taatcttctt     2400

gaggccagtg taattacaaa acaggaacat gatattatta gacagaaaac acagataccc     2460

ttacaagcaa gagagcttat tgacaccgtt ttagtcaagg gaaatgctgc agccaacatc     2520

ttcaaaaact ctctgaagga aattgactcc acgttatatg aaaacttatt tgtggaaaag     2580

aatatgaagt atattccaac agaagacgtt tcaggcttgt cattggaaga gcagttgcgg     2640

agattacaag aagaacgaac ttgcaaagtg tgtatggaca gagaggtttc tattgtgttc     2700

attccgtgtg gtcatctagt agtctgccag gaatgtgccc cttctctaag gaagtgcccc     2760

atctgcaggg ggacaatcaa ggggactgtg cgcacatttc tctcatgagt gaagaatggt     2820

ctgaaagtat tgttggacat cagaagctgt cagaacaaag aatgaactac tgatttcagc     2880

tcttcagcag gacattctac tctctttcaa gattagtaat cttgctttat gaagggtagc     2940

attgtatatt taagcttagt ctgttgcaag ggaaggtcta tgctgttgag ctacaggact     3000

gtgtctgttc cagagcagga gttgggatgc ttgctgtatg tccttcagga cttcttggat     3060

ttggaatttg tgaaagcttt ggattcaggt gatgtggagc tcagaaatcc tgaaaccagt     3120

ggctctggta ctcagtagtt agggtaccct gtgcttcttg gtgcttttcc tttctggaaa     3180

ataaggattt ttctgctact ggtaaatatt ttctgtttgt gagaaatata ttaaagtgtt     3240

tcttttaaag gcgtgcatca ttgtagtgtg tgcagggatg tatgcaggca aaacactgtg     3300

tatataataa ataaatcttt ttaaaaagtg tta                                  3333


<210>  13
<211>  3377
<212>  DNA
<213>  Mus musculus

<400>  13
cagtcaaccc aggctagtct cgaatttgcg gcaatcctcc tgcctccaat cgttctaggt       60

gctgggatta ctggtgtgca gcacctcggc tgtctcttca gattttctgc agattgatag      120

tcctcaagag tcttcatgtt ctcttatgtt tttctagaaa tcagcccact catggacatc      180

tgaacatttc tataagacgc tgcggtttgc tttgcagtgt gttcttgtgt atgattagtt      240

atataaaata cgaagttttc aaaaagaagg ctagtgcaac agaaaagctt tgctaaaaca      300

gattcttagt tatttgaggt aacaaaagaa agccatgtct tgaattgatt cgttcttaat      360

tataacagac ttatagtgga aagggcctta aacacaggcg gactttataa aatgcagtct      420

taggtttatg tgcaaaatac tgtctgttga ccagatgtat tcacatgata tatacagagt      480

caaggtggtg atatagaaga tttaacagtg agggagttaa cagtctgtgc tttaagcgca      540

gttcctttac agtgaatact gtagtcttaa tagacctgag ctgactgctg cagttgatgt      600

aacccacttt agagaatact gtatgacatc ttctctaagg aaaaccagct gcagacttca      660

ctcagttcct ttcatttcat aggaaaagga gtagttcaga tgtcatgttt aagtccttat      720

aagggaaaag agcctgaata tatgccctag tacctaggct tcataactag taataagaag      780

ttagttatgg gtaaatagat ctcaggttac ccagaagagt tcatgtgacc cccaaagagt      840

cctaactagt gtcttggcaa gtgagacaga tttgtcctgt gagggtgtca attcaccagt      900

ccaagcagaa gacaatgaat ctatccagtc aggtgtctgt ggtggagatc tagtgtcaag      960

tggtgagaaa cttcatctgg aagtttaagc ggtcagaaat actattacta ctcatggaca     1020

aaactgtctc ccagagactc ggccaaggta ccttacacca aaaacttaaa cgtataatgg     1080

agaagagcac aatcttgtca aattggacaa aggagagcga agaaaaaatg aagtttgact     1140

tttcgtgtga actctaccga atgtctacat attcagcttt tcccagggga gttcctgtct     1200

cagagaggag tctggctcgt gctggctttt attatacagg tgtgaatgac aaagtcaagt     1260

gcttctgctg tggcctgatg ttggataact ggaaacaagg ggacagtcct gttgaaaagc     1320

acagacagtt ctatcccagc tgcagctttg tacagactct gctttcagcc agtctgcagt     1380

ctccatctaa gaatatgtct cctgtgaaaa gtagatttgc acattcgtca cctctggaac     1440

gaggtggcat tcactccaac ctgtgctcta gccctcttaa ttctagagca gtggaagact     1500

tctcatcaag gatggatccc tgcagctatg ccatgagtac agaagaggcc agatttctta     1560

cttacagtat gtggccttta agttttctgt caccagcaga gctggccaga gctggcttct     1620

attacatagg gcctggagac agggtggcct gttttgcctg tggtgggaaa ctgagcaact     1680

gggaaccaaa ggatgatgct atgtcagagc accgcagaca ttttccccac tgtccatttc     1740

tggaaaatac ttcagaaaca cagaggttta gtatatcaaa tctaagtatg cagacacact     1800

ctgctcgatt gaggacattt ctgtactggc cacctagtgt tcctgttcag cccgagcagc     1860

ttgcaagtgc tggattctat tacgtggatc gcaatgatga tgtcaagtgc ttttgttgtg     1920

atggtggctt gagatgttgg gaacctggag atgacccctg gatagaacac gccaaatggt     1980

ttccaaggtg tgagttcttg atacggatga agggtcagga gtttgttgat gagattcaag     2040

ctagatatcc tcatcttctt gagcagctgt tgtccacttc agacacccca ggagaagaaa     2100

atgctgaccc tacagagaca gtggtgcatt ttggccctgg agaaagttcg gaagatgtcg     2160

tcatgatgag cacgcctgtg gttaaagcag ccttggaaat gggcttcagt aggagcctgg     2220

tgagacagac ggttcagcgg cagatcctgg ccactggtga gaactacagg accgtcaatg     2280

atattgtctc agtacttttg aatgctgaag atgagagaag agaagaggag aaggaaagac     2340

agactgaaga gatggcatca ggtgacttat cactgattcg gaagaataga atggccctct     2400

ttcaacagtt gacacatgtc cttcctatcc tggataatct tcttgaggcc agtgtaatta     2460

caaaacagga acatgatatt attagacaga aaacacagat acccttacaa gcaagagagc     2520

ttattgacac cgttttagtc aagggaaatg ctgcagccaa catcttcaaa aactctctga     2580

aggaaattga ctccacgtta tatgaaaact tatttgtgga aaagaatatg aagtatattc     2640

caacagaaga cgtttcaggc ttgtcattgg aagagcagtt gcggagatta caagaagaac     2700

gaacttgcaa agtgtgtatg gacagagagg tttctattgt gttcattccg tgtggtcatc     2760

tagtagtctg ccaggaatgt gccccttctc taaggaagtg ccccatctgc agggggacaa     2820

tcaaggggac tgtgcgcaca tttctctcat gagtgaagaa tggtctgaaa gtattgttgg     2880

acatcagaag ctgtcagaac aaagaatgaa ctactgattt cagctcttca gcaggacatt     2940

ctactctctt tcaagattag taatcttgct ttatgaaggg tagcattgta tatttaagct     3000

tagtctgttg caagggaagg tctatgctgt tgagctacag gactgtgtct gttccagagc     3060

aggagttggg atgcttgctg tatgtccttc aggacttctt ggatttggaa tttgtgaaag     3120

ctttggattc aggtgatgtg gagctcagaa atcctgaaac cagtggctct ggtactcagt     3180

agttagggta ccctgtgctt cttggtgctt ttcctttctg gaaaataagg atttttctgc     3240

tactggtaaa tattttctgt ttgtgagaaa tatattaaag tgtttctttt aaaggcgtgc     3300

atcattgtag tgtgtgcagg gatgtatgca ggcaaaacac tgtgtatata ataaataaat     3360

ctttttaaaa agtgtta                                                    3377


<210>  14
<211>  612
<212>  PRT
<213>  Mus musculus

<400>  14

Met Asp Lys Thr Val Ser Gln Arg Leu Gly Gln Gly Thr Leu His Gln 
1               5                   10                  15      


Lys Leu Lys Arg Ile Met Glu Lys Ser Thr Ile Leu Ser Asn Trp Thr 
            20                  25                  30          


Lys Glu Ser Glu Glu Lys Met Lys Phe Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Ala Phe Pro Arg Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Gln Gly 
                85                  90                  95      


Asp Ser Pro Val Glu Lys His Arg Gln Phe Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Val Gln Thr Leu Leu Ser Ala Ser Leu Gln Ser Pro Ser Lys Asn Met 
        115                 120                 125             


Ser Pro Val Lys Ser Arg Phe Ala His Ser Ser Pro Leu Glu Arg Gly 
    130                 135                 140                 


Gly Ile His Ser Asn Leu Cys Ser Ser Pro Leu Asn Ser Arg Ala Val 
145                 150                 155                 160 


Glu Asp Phe Ser Ser Arg Met Asp Pro Cys Ser Tyr Ala Met Ser Thr 
                165                 170                 175     


Glu Glu Ala Arg Phe Leu Thr Tyr Ser Met Trp Pro Leu Ser Phe Leu 
            180                 185                 190         


Ser Pro Ala Glu Leu Ala Arg Ala Gly Phe Tyr Tyr Ile Gly Pro Gly 
        195                 200                 205             


Asp Arg Val Ala Cys Phe Ala Cys Gly Gly Lys Leu Ser Asn Trp Glu 
    210                 215                 220                 


Pro Lys Asp Asp Ala Met Ser Glu His Arg Arg His Phe Pro His Cys 
225                 230                 235                 240 


Pro Phe Leu Glu Asn Thr Ser Glu Thr Gln Arg Phe Ser Ile Ser Asn 
                245                 250                 255     


Leu Ser Met Gln Thr His Ser Ala Arg Leu Arg Thr Phe Leu Tyr Trp 
            260                 265                 270         


Pro Pro Ser Val Pro Val Gln Pro Glu Gln Leu Ala Ser Ala Gly Phe 
        275                 280                 285             


Tyr Tyr Val Asp Arg Asn Asp Asp Val Lys Cys Phe Cys Cys Asp Gly 
    290                 295                 300                 


Gly Leu Arg Cys Trp Glu Pro Gly Asp Asp Pro Trp Ile Glu His Ala 
305                 310                 315                 320 


Lys Trp Phe Pro Arg Cys Glu Phe Leu Ile Arg Met Lys Gly Gln Glu 
                325                 330                 335     


Phe Val Asp Glu Ile Gln Ala Arg Tyr Pro His Leu Leu Glu Gln Leu 
            340                 345                 350         


Leu Ser Thr Ser Asp Thr Pro Gly Glu Glu Asn Ala Asp Pro Thr Glu 
        355                 360                 365             


Thr Val Val His Phe Gly Pro Gly Glu Ser Ser Glu Asp Val Val Met 
    370                 375                 380                 


Met Ser Thr Pro Val Val Lys Ala Ala Leu Glu Met Gly Phe Ser Arg 
385                 390                 395                 400 


Ser Leu Val Arg Gln Thr Val Gln Arg Gln Ile Leu Ala Thr Gly Glu 
                405                 410                 415     


Asn Tyr Arg Thr Val Asn Asp Ile Val Ser Val Leu Leu Asn Ala Glu 
            420                 425                 430         


Asp Glu Arg Arg Glu Glu Glu Lys Glu Arg Gln Thr Glu Glu Met Ala 
        435                 440                 445             


Ser Gly Asp Leu Ser Leu Ile Arg Lys Asn Arg Met Ala Leu Phe Gln 
    450                 455                 460                 


Gln Leu Thr His Val Leu Pro Ile Leu Asp Asn Leu Leu Glu Ala Ser 
465                 470                 475                 480 


Val Ile Thr Lys Gln Glu His Asp Ile Ile Arg Gln Lys Thr Gln Ile 
                485                 490                 495     


Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr Val Leu Val Lys Gly Asn 
            500                 505                 510         


Ala Ala Ala Asn Ile Phe Lys Asn Ser Leu Lys Glu Ile Asp Ser Thr 
        515                 520                 525             


Leu Tyr Glu Asn Leu Phe Val Glu Lys Asn Met Lys Tyr Ile Pro Thr 
    530                 535                 540                 


Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln Leu Arg Arg Leu Gln 
545                 550                 555                 560 


Glu Glu Arg Thr Cys Lys Val Cys Met Asp Arg Glu Val Ser Ile Val 
                565                 570                 575     


Phe Ile Pro Cys Gly His Leu Val Val Cys Gln Glu Cys Ala Pro Ser 
            580                 585                 590         


Leu Arg Lys Cys Pro Ile Cys Arg Gly Thr Ile Lys Gly Thr Val Arg 
        595                 600                 605             


Thr Phe Leu Ser 
    610         


<210>  15
<211>  3098
<212>  DNA
<213>  Homo sapiens

<400>  15
gcacccgcac cggcgcgccg gccgtcggtc acgtggcctc cggccagggc ttgcgaagcc       60

ggaagtgtcc tgagtctcga ggaggccgcg ggagcccgcc ggcggtggcg cggcggagac      120

ccggctggta taacaagagg attgcctgat ccagccaaga tgcagagcac ttctaatcat      180

ctgtggcttt tatctgatat tttaggccaa ggagctactg caaatgtctt tcgtggaaga      240

cataagaaaa ctggtgattt atttgctatc aaagtattta ataacataag cttccttcgt      300

ccagtggatg ttcaaatgag agaatttgaa gtgttgaaaa aactcaatca caaaaatatt      360

gtcaaattat ttgctattga agaggagaca acaacaagac ataaagtact tattatggaa      420

ttttgtccat gtgggagttt atacactgtt ttagaagaac cttctaatgc ctatggacta      480

ccagaatctg aattcttaat tgttttgcga gatgtggtgg gtggaatgaa tcatctacga      540

gagaatggta tagtgcaccg tgatatcaag ccaggaaata tcatgcgtgt tataggggaa      600

gatggacagt ctgtgtacaa actcacagat tttggtgcag ctagagaatt agaagatgat      660

gagcagtttg tttctctgta tggcacagaa gaatatttgc accctgatat gtatgagaga      720

gcagtgctaa gaaaagatca tcagaagaaa tatggagcaa cagttgatct ttggagcatt      780

ggggtaacat tttaccatgc agctactgga tcactgccat ttagaccctt tgaagggcct      840

cgtaggaata aagaagtgat gtataaaata attacaggaa agccttctgg tgcaatatct      900

ggagtacaga aagcagaaaa tggaccaatt gactggagtg gagacatgcc tgtttcttgc      960

agtctttctc ggggtcttca ggttctactt acccctgttc ttgcaaacat ccttgaagca     1020

gatcaggaaa agtgttgggg ttttgaccag ttttttgcag aaactagtga tatacttcac     1080

cgaatggtaa ttcatgtttt ttcgctacaa caaatgacag ctcataagat ttatattcat     1140

agctataata ctgctactat atttcatgaa ctggtatata aacaaaccaa aattatttct     1200

tcaaatcaag aacttatcta cgaagggcga cgcttagtct tagaacctgg aaggctggca     1260

caacatttcc ctaaaactac tgaggaaaac cctatatttg tagtaagccg ggaacctctg     1320

aataccatag gattaatata tgaaaaaatt tccctcccta aagtacatcc acgttatgat     1380

ttagacgggg atgctagcat ggctaaggca ataacagggg ttgtgtgtta tgcctgcaga     1440

attgccagta ccttactgct ttatcaggaa ttaatgcgaa aggggatacg atggctgatt     1500

gaattaatta aagatgatta caatgaaact gttcacaaaa agacagaagt tgtgatcaca     1560

ttggatttct gtatcagaaa cattgaaaaa actgtgaaag tatatgaaaa gttgatgaag     1620

atcaacctgg aagcggcaga gttaggtgaa atttcagaca tacacaccaa attgttgaga     1680

ctttccagtt ctcagggaac aatagaaacc agtcttcagg atatcgacag cagattatct     1740

ccaggtggat cactggcaga cgcatgggca catcaagaag gcactcatcc gaaagacaga     1800

aatgtagaaa aactacaagt cctgttaaat tgcatgacag agatttacta tcagttcaaa     1860

aaagacaaag cagaacgtag attagcttat aatgaagaac aaatccacaa atttgataag     1920

caaaaactgt attaccatgc cacaaaagct atgacgcact ttacagatga atgtgttaaa     1980

aagtatgagg catttttgaa taagtcagaa gaatggataa gaaagatgct tcatcttagg     2040

aaacagttat tatcgctgac taatcagtgt tttgatattg aagaagaagt atcaaaatat     2100

caagaatata ctaatgagtt acaagaaact ctgcctcaga aaatgtttac agcttccagt     2160

ggaatcaaac ataccatgac cccaatttat ccaagttcta acacattagt agaaatgact     2220

cttggtatga agaaattaaa ggaagagatg gaaggggtgg ttaaagaact tgctgaaaat     2280

aaccacattt tagaaaggtt tggctcttta accatggatg gtggccttcg caacgttgac     2340

tgtctttagc tttctaatag aagtttaaga aaagtttccg tttgcacaag aaaataacgc     2400

ttgggcatta aatgaatgcc tttatagata gtcacttgtt tctacaattc agtatttgat     2460

gtggtcgtgt aaatatgtac aatattgtaa atacataaaa aatatacaaa tttttggctg     2520

ctgtgaagat gtaattttat cttttaacat ttataattat atgaggaaat ttgacctcag     2580

tgatcacgag aagaaagcca tgaccgacca atatgttgac atactgatcc tctactctga     2640

gtggggctaa ataagttatt ttctctgacc gcctactgga aatattttta agtggaacca     2700

aaataggcat ccttacaaat caggaagact gacttgacac gtttgtaaat ggtagaacgg     2760

tggctactgt gagtggggag cagaaccgca ccactgttat actgggataa caattttttt     2820

gagaaggata aagtggcatt attttatttt acaaggtgcc cagatcccag ttatccttgt     2880

atccatgtaa tttcagatga attattaagc aaacatttta aagtgaattc attattaaaa     2940

actattcatt tttttccttt ggccataaat gtgtaattgt cattaaaatt ctaaggtcat     3000

ttcaactgtt ttaagctgta tatttcttta attctgctta ctatttcatg gaaaaaaata     3060

aatttctcaa ttttaatgta aagagttaaa aaaaaaaa                             3098


<210>  16
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Ser Thr Ser Asn His Leu Trp Leu Leu Ser Asp Ile Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Asn Val Phe Arg Gly Arg His Lys Lys Thr Gly 
            20                  25                  30          


Asp Leu Phe Ala Ile Lys Val Phe Asn Asn Ile Ser Phe Leu Arg Pro 
        35                  40                  45              


Val Asp Val Gln Met Arg Glu Phe Glu Val Leu Lys Lys Leu Asn His 
    50                  55                  60                  


Lys Asn Ile Val Lys Leu Phe Ala Ile Glu Glu Glu Thr Thr Thr Arg 
65                  70                  75                  80  


His Lys Val Leu Ile Met Glu Phe Cys Pro Cys Gly Ser Leu Tyr Thr 
                85                  90                  95      


Val Leu Glu Glu Pro Ser Asn Ala Tyr Gly Leu Pro Glu Ser Glu Phe 
            100                 105                 110         


Leu Ile Val Leu Arg Asp Val Val Gly Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Val 
    130                 135                 140                 


Ile Gly Glu Asp Gly Gln Ser Val Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Glu Asp Asp Glu Gln Phe Val Ser Leu Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Asp His Gln Lys Lys Tyr Gly Ala Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Phe Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Arg Pro Phe 
    210                 215                 220                 


Glu Gly Pro Arg Arg Asn Lys Glu Val Met Tyr Lys Ile Ile Thr Gly 
225                 230                 235                 240 


Lys Pro Ser Gly Ala Ile Ser Gly Val Gln Lys Ala Glu Asn Gly Pro 
                245                 250                 255     


Ile Asp Trp Ser Gly Asp Met Pro Val Ser Cys Ser Leu Ser Arg Gly 
            260                 265                 270         


Leu Gln Val Leu Leu Thr Pro Val Leu Ala Asn Ile Leu Glu Ala Asp 
        275                 280                 285             


Gln Glu Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu His Arg Met Val Ile His Val Phe Ser Leu Gln Gln Met Thr 
305                 310                 315                 320 


Ala His Lys Ile Tyr Ile His Ser Tyr Asn Thr Ala Thr Ile Phe His 
                325                 330                 335     


Glu Leu Val Tyr Lys Gln Thr Lys Ile Ile Ser Ser Asn Gln Glu Leu 
            340                 345                 350         


Ile Tyr Glu Gly Arg Arg Leu Val Leu Glu Pro Gly Arg Leu Ala Gln 
        355                 360                 365             


His Phe Pro Lys Thr Thr Glu Glu Asn Pro Ile Phe Val Val Ser Arg 
    370                 375                 380                 


Glu Pro Leu Asn Thr Ile Gly Leu Ile Tyr Glu Lys Ile Ser Leu Pro 
385                 390                 395                 400 


Lys Val His Pro Arg Tyr Asp Leu Asp Gly Asp Ala Ser Met Ala Lys 
                405                 410                 415     


Ala Ile Thr Gly Val Val Cys Tyr Ala Cys Arg Ile Ala Ser Thr Leu 
            420                 425                 430         


Leu Leu Tyr Gln Glu Leu Met Arg Lys Gly Ile Arg Trp Leu Ile Glu 
        435                 440                 445             


Leu Ile Lys Asp Asp Tyr Asn Glu Thr Val His Lys Lys Thr Glu Val 
    450                 455                 460                 


Val Ile Thr Leu Asp Phe Cys Ile Arg Asn Ile Glu Lys Thr Val Lys 
465                 470                 475                 480 


Val Tyr Glu Lys Leu Met Lys Ile Asn Leu Glu Ala Ala Glu Leu Gly 
                485                 490                 495     


Glu Ile Ser Asp Ile His Thr Lys Leu Leu Arg Leu Ser Ser Ser Gln 
            500                 505                 510         


Gly Thr Ile Glu Thr Ser Leu Gln Asp Ile Asp Ser Arg Leu Ser Pro 
        515                 520                 525             


Gly Gly Ser Leu Ala Asp Ala Trp Ala His Gln Glu Gly Thr His Pro 
    530                 535                 540                 


Lys Asp Arg Asn Val Glu Lys Leu Gln Val Leu Leu Asn Cys Met Thr 
545                 550                 555                 560 


Glu Ile Tyr Tyr Gln Phe Lys Lys Asp Lys Ala Glu Arg Arg Leu Ala 
                565                 570                 575     


Tyr Asn Glu Glu Gln Ile His Lys Phe Asp Lys Gln Lys Leu Tyr Tyr 
            580                 585                 590         


His Ala Thr Lys Ala Met Thr His Phe Thr Asp Glu Cys Val Lys Lys 
        595                 600                 605             


Tyr Glu Ala Phe Leu Asn Lys Ser Glu Glu Trp Ile Arg Lys Met Leu 
    610                 615                 620                 


His Leu Arg Lys Gln Leu Leu Ser Leu Thr Asn Gln Cys Phe Asp Ile 
625                 630                 635                 640 


Glu Glu Glu Val Ser Lys Tyr Gln Glu Tyr Thr Asn Glu Leu Gln Glu 
                645                 650                 655     


Thr Leu Pro Gln Lys Met Phe Thr Ala Ser Ser Gly Ile Lys His Thr 
            660                 665                 670         


Met Thr Pro Ile Tyr Pro Ser Ser Asn Thr Leu Val Glu Met Thr Leu 
        675                 680                 685             


Gly Met Lys Lys Leu Lys Glu Glu Met Glu Gly Val Val Lys Glu Leu 
    690                 695                 700                 


Ala Glu Asn Asn His Ile Leu Glu Arg Phe Gly Ser Leu Thr Met Asp 
705                 710                 715                 720 


Gly Gly Leu Arg Asn Val Asp Cys Leu 
                725                 


<210>  17
<211>  3031
<212>  DNA
<213>  Mus musculus

<400>  17
tcggtcacgt gctccgtggc ccgggctggc gaagccggaa gtagcctggg gcgcgagaag       60

gcccgggagc cgcgggctgt acgcggcgga cactcgcggg catacatgca aatctcttct      120

tcccccttat cgtgaggaga agcgcctgga caagccgaga tgcagagcac ctccaaccat      180

ctgtggctcc tgtctgatat cctaggccag ggggccactg caaatgtctt ccgaggaagg      240

cataagaaaa ctggtgatct ctatgctgtc aaagtattta ataacataag cttccttcgc      300

ccagtggatg ttcaaatgag agaatttgaa gtgttaaaaa aactcaatca caaaaacatt      360

gtcaagttat ttgctattga agaggagaca acaacaagac ataaagtgct tattatggag      420

ttttgtccct gtgggagttt atacactgtt ctagaggagc cgtccaatgc gtatggactt      480

ccagaatcag aatttctcat tgtcttacga gatgtggtgg gcgggatgaa tcatctccga      540

gagaacggca tagtgcaccg agatatcaag ccaggcaaca tcatgcgcgt cataggggag      600

gacggccagt ctgtgtacaa actcacggat ttcggcgccg ctcgagagct ggaggacgat      660

gagcagtttg tgtctctgta cggcacagaa gagtacctgc atccggacat gtatgaaagg      720

gcagtgctaa gaaaggacca tcagaagaag tacggggcta ccgttgatct gtggagtgtt      780

ggagtgacat tctaccatgc agccacgggg tcgctgccgt ttagaccctt cgaggggcct      840

cggaggaaca aagaagtaat gtataaaata atcactggga agccgtctgg tgcaatatct      900

ggagtacaga aagcagaaaa cggaccaatt gactggagtg gagacatgcc tctctcctgt      960

agtctttctc agggtcttca ggcactgctt accccagttc ttgcaaacat acttgaagct     1020

gatcaggaga agtgctgggg ttttgaccag ttctttgcag agaccagtga tgtgcttcac     1080

cgaatggtga tccatgtctt ctcgctacaa cacatgacgg cgcataagat ttacattcac     1140

agctataaca ctgctgctgt gttccatgaa ctggtctata aacaaaccaa gattgtttcc     1200

tcaaatcaag aacttatcta cgaaggacga cgcttagtcc tagaactcgg acgactagcc     1260

cagcattttc ctaaaaccac agaggaaaat cctatctttg tcacgagccg ggaacaactc     1320

aataccgtag gactgagata tgaaaaaatt tccctcccta aaatacatcc acgctatgat     1380

ctggatgggg acgccagcat ggccaaggca gtgacggggg ttgtgtgcta cgcctgcaga     1440

actgccagta ccctgctgct ctatcaagaa ttaatgcgaa agggggtacg gtggctggtt     1500

gaactggtta aggatgatta caacgagacc gtccacaaga agacggaggt agtgatcaca     1560

ctggatttct gcatcaggaa cattgagaag actgtgaaag tgtatgagaa gttgatgaag     1620

gtcaacctgg aagccgcaga gctgggtgag atttcagaca tacacaccaa gctgctgaga     1680

ctttccagtt ctcagggaac aatagaaagc agtcttcagg acatcagcag caggctgtct     1740

ccagggggct tgctggccga cacctgggca catcaagaag gcacgcatcc aagagacagg     1800

aatgtagaaa aactgcaggt cctgttgaac tgcatcacag agatttacta tcagttcaaa     1860

aaagacaaag cagaacgcag actagcttat aatgaagaac agatccacaa atttgataag     1920

caaaaattgt attaccatgc cacaaaagca atgagccact tctcagaaga atgtgttaga     1980

aagtatgaag cgtttaaaga taagtcggaa gagtggatga gaaagatgct tcatcttagg     2040

aagcagctgt tatcgctaac taatcagtgt ttcgatatcg aagaggaagt gtccaagtat     2100

caagactata ctaacgagtt acaagaaact ctgcctcaga aaatgctcgc agcctccggc     2160

ggcgtcaagc acgccatggc cccgatctac cccagctcta acaccttagt ggagatgact     2220

cttggtatga agaagttaaa ggaggagatg gaaggcgtgg ttaaggagct ggccgagaac     2280

aatcatattt tagaaaggtt tgggtcttta acaatggatg gtggccttcg caatgtggac     2340

tgtctttagc ttcctaggga gtctgggaag ttctagtttg cacaagaaga taacactggg     2400

gcacgaaatg aacacctttg tgaatggagt tcttatttct acacttcagt atttgatgag     2460

gtcatgtaaa tatgtacagt ttgtaaatac atatacatat atatatatat atatgaattt     2520

tggctgctgt aacaaagaca gattgacctc agcgagctgt agaagaaagc catgaccagc     2580

cagtgctttg gggtgctctc cctaattctt cacataaggc tggagaaatc aattgcttgg     2640

tgcctaaaga aagtattttt tgaattggca ttcttaaaat tttgaaagga ctgatagtcg     2700

acacagtgta actggaggag acacagggct ttgtgacggg aacagaaccg cggtttaacc     2760

acagtcggtt ccctgacaag gataaagtgg cattatctca tttgaccggg tgcccaaatc     2820

tcagttttcc tcggatgttt gattttaggt gaattattga gcaaaaactt taaagtgaat     2880

tcattgttta aactattcat ttttcctttg gtcatgaatg tgtaattgtc attcagatcc     2940

tagtatcatt tcaattgtct taagatgtat atttctgtac tttaattctg ctatttcatg     3000

aaaaaataaa tttctcaatt ttaatgtaaa a                                    3031


<210>  18
<211>  729
<212>  PRT
<213>  Mus musculus

<400>  18

Met Gln Ser Thr Ser Asn His Leu Trp Leu Leu Ser Asp Ile Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Asn Val Phe Arg Gly Arg His Lys Lys Thr Gly 
            20                  25                  30          


Asp Leu Tyr Ala Val Lys Val Phe Asn Asn Ile Ser Phe Leu Arg Pro 
        35                  40                  45              


Val Asp Val Gln Met Arg Glu Phe Glu Val Leu Lys Lys Leu Asn His 
    50                  55                  60                  


Lys Asn Ile Val Lys Leu Phe Ala Ile Glu Glu Glu Thr Thr Thr Arg 
65                  70                  75                  80  


His Lys Val Leu Ile Met Glu Phe Cys Pro Cys Gly Ser Leu Tyr Thr 
                85                  90                  95      


Val Leu Glu Glu Pro Ser Asn Ala Tyr Gly Leu Pro Glu Ser Glu Phe 
            100                 105                 110         


Leu Ile Val Leu Arg Asp Val Val Gly Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Val 
    130                 135                 140                 


Ile Gly Glu Asp Gly Gln Ser Val Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Glu Asp Asp Glu Gln Phe Val Ser Leu Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Asp His Gln Lys Lys Tyr Gly Ala Thr Val Asp Leu Trp Ser Val Gly 
        195                 200                 205             


Val Thr Phe Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Arg Pro Phe 
    210                 215                 220                 


Glu Gly Pro Arg Arg Asn Lys Glu Val Met Tyr Lys Ile Ile Thr Gly 
225                 230                 235                 240 


Lys Pro Ser Gly Ala Ile Ser Gly Val Gln Lys Ala Glu Asn Gly Pro 
                245                 250                 255     


Ile Asp Trp Ser Gly Asp Met Pro Leu Ser Cys Ser Leu Ser Gln Gly 
            260                 265                 270         


Leu Gln Ala Leu Leu Thr Pro Val Leu Ala Asn Ile Leu Glu Ala Asp 
        275                 280                 285             


Gln Glu Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Val Leu His Arg Met Val Ile His Val Phe Ser Leu Gln His Met Thr 
305                 310                 315                 320 


Ala His Lys Ile Tyr Ile His Ser Tyr Asn Thr Ala Ala Val Phe His 
                325                 330                 335     


Glu Leu Val Tyr Lys Gln Thr Lys Ile Val Ser Ser Asn Gln Glu Leu 
            340                 345                 350         


Ile Tyr Glu Gly Arg Arg Leu Val Leu Glu Leu Gly Arg Leu Ala Gln 
        355                 360                 365             


His Phe Pro Lys Thr Thr Glu Glu Asn Pro Ile Phe Val Thr Ser Arg 
    370                 375                 380                 


Glu Gln Leu Asn Thr Val Gly Leu Arg Tyr Glu Lys Ile Ser Leu Pro 
385                 390                 395                 400 


Lys Ile His Pro Arg Tyr Asp Leu Asp Gly Asp Ala Ser Met Ala Lys 
                405                 410                 415     


Ala Val Thr Gly Val Val Cys Tyr Ala Cys Arg Thr Ala Ser Thr Leu 
            420                 425                 430         


Leu Leu Tyr Gln Glu Leu Met Arg Lys Gly Val Arg Trp Leu Val Glu 
        435                 440                 445             


Leu Val Lys Asp Asp Tyr Asn Glu Thr Val His Lys Lys Thr Glu Val 
    450                 455                 460                 


Val Ile Thr Leu Asp Phe Cys Ile Arg Asn Ile Glu Lys Thr Val Lys 
465                 470                 475                 480 


Val Tyr Glu Lys Leu Met Lys Val Asn Leu Glu Ala Ala Glu Leu Gly 
                485                 490                 495     


Glu Ile Ser Asp Ile His Thr Lys Leu Leu Arg Leu Ser Ser Ser Gln 
            500                 505                 510         


Gly Thr Ile Glu Ser Ser Leu Gln Asp Ile Ser Ser Arg Leu Ser Pro 
        515                 520                 525             


Gly Gly Leu Leu Ala Asp Thr Trp Ala His Gln Glu Gly Thr His Pro 
    530                 535                 540                 


Arg Asp Arg Asn Val Glu Lys Leu Gln Val Leu Leu Asn Cys Ile Thr 
545                 550                 555                 560 


Glu Ile Tyr Tyr Gln Phe Lys Lys Asp Lys Ala Glu Arg Arg Leu Ala 
                565                 570                 575     


Tyr Asn Glu Glu Gln Ile His Lys Phe Asp Lys Gln Lys Leu Tyr Tyr 
            580                 585                 590         


His Ala Thr Lys Ala Met Ser His Phe Ser Glu Glu Cys Val Arg Lys 
        595                 600                 605             


Tyr Glu Ala Phe Lys Asp Lys Ser Glu Glu Trp Met Arg Lys Met Leu 
    610                 615                 620                 


His Leu Arg Lys Gln Leu Leu Ser Leu Thr Asn Gln Cys Phe Asp Ile 
625                 630                 635                 640 


Glu Glu Glu Val Ser Lys Tyr Gln Asp Tyr Thr Asn Glu Leu Gln Glu 
                645                 650                 655     


Thr Leu Pro Gln Lys Met Leu Ala Ala Ser Gly Gly Val Lys His Ala 
            660                 665                 670         


Met Ala Pro Ile Tyr Pro Ser Ser Asn Thr Leu Val Glu Met Thr Leu 
        675                 680                 685             


Gly Met Lys Lys Leu Lys Glu Glu Met Glu Gly Val Val Lys Glu Leu 
    690                 695                 700                 


Ala Glu Asn Asn His Ile Leu Glu Arg Phe Gly Ser Leu Thr Met Asp 
705                 710                 715                 720 


Gly Gly Leu Arg Asn Val Asp Cys Leu 
                725                 


<210>  19
<211>  7793
<212>  DNA
<213>  Homo sapiens

<400>  19
gggagcgcgg cgcggccgcc gcgtgcgcga gccggggttg cagcccagcc gggactttcc       60

agccggcggc agccgcggcg gccgccggct cttccccgcc ccccgccatg gggcagcccg      120

gggagcagaa cgctgcggac cgcggcggag gacgcgcccg gcgcccctga gccggccgag      180

cggcgacgga ccgcgagatg aggaaaatga ggcccaaaga agtgatgcca cttggttaag      240

gtcccagagc aggtcagaat cagacctagg atcagaaacc tggctcctgg ctcctggctc      300

cctactcttc taaggatcgc tgtcctgaca gaagagaact cctctttcct aaaatggagt      360

cgagtaaaaa gatggactct cctggcgcgc tgcagactaa cccgccgcta aagctgcaca      420

ctgaccgcag tgctgggacg ccagtttttg tccctgaaca aggaggttac aaggaaaagt      480

ttgtgaagac cgtggaggac aagtacaagt gtgagaagtg ccacctggtg ctgtgcagcc      540

cgaagcagac cgagtgtggg caccgcttct gcgagagctg catggcggcc ctgctgagct      600

cttcaagtcc aaaatgtaca gcgtgtcaag agagcatcgt taaagataag gtgtttaagg      660

ataattgctg caagagagaa attctggctc ttcagatcta ttgtcggaat gaaagcagag      720

gttgtgcaga gcagttaatg ctgggacatc tgctggtgca tttaaaaaat gattgccatt      780

ttgaagaact tccatgtgtg cgtcctgact gcaaagaaaa ggtcttgagg aaagacctgc      840

gagaccacgt ggagaaggcg tgtaaatacc gggaagccac atgcagccac tgcaagagtc      900

aggttccgat gatcgcgctg cagaaacacg aagacaccga ctgtccctgc gtggtggtgt      960

cctgccctca caagtgcagc gtccagactc tcctgaggag cgagttgagt gcacacttgt     1020

cagagtgtgt caatgccccc agcacctgta gttttaagcg ctatggctgc gtttttcagg     1080

ggacaaacca gcagatcaag gcccacgagg ccagctccgc cgtgcagcac gtcaacctgc     1140

tgaaggagtg gagcaactcg ctcgaaaaga aggtttcctt gttgcagaat gaaagtgtag     1200

aaaaaaacaa gagcatacaa agtttgcaca atcagatatg tagctttgaa attgaaattg     1260

agagacaaaa ggaaatgctt cgaaataatg aatccaaaat ccttcattta cagcgagtga     1320

tagacagcca agcagagaaa ctgaaggagc ttgacaagga gatccggccc ttccggcaga     1380

actgggagga agcagacagc atgaagagca gcgtggagtc cctccagaac cgcgtgaccg     1440

agctggagag cgtggacaag agcgcggggc aagtggctcg gaacacaggc ctgctggagt     1500

cccagctgag ccggcatgac cagatgctga gtgtgcacga catccgccta gccgacatgg     1560

acctgcgctt ccaggtcctg gagaccgcca gctacaatgg agtgctcatc tggaagattc     1620

gcgactacaa gcggcggaag caggaggccg tcatggggaa gaccctgtcc ctttacagcc     1680

agcctttcta cactggttac tttggctata agatgtgtgc cagggtctac ctgaacgggg     1740

acgggatggg gaaggggacg cacttgtcgc tgttttttgt catcatgcgt ggagaatatg     1800

atgccctgct tccttggccg tttaagcaga aagtgacact catgctgatg gatcaggggt     1860

cctctcgacg tcatttggga gatgcattca agcccgaccc caacagcagc agcttcaaga     1920

agcccactgg agagatgaat atcgcctctg gctgcccagt ctttgtggcc caaactgttc     1980

tagaaaatgg gacatatatt aaagatgata caatttttat taaagtcata gtggatactt     2040

cggatctgcc cgatccctga taagtagctg gggaggtgga tttagcagaa ggcaactcct     2100

ctgggggatt tgaaccggtc tgtcttcact gaggtcctcg cgctcagaaa aggaccttgt     2160

gagacggagg aagcggcaga aggcggacgc gtgccggcgg gaggagccac gcgtgagcac     2220

acctgacacg ttttataata gactagccac acttcactct gaagaattat ttatccttca     2280

acaagataaa tattgctgtc agagaaggtt ttcattttca tttttaaaga tctagttaat     2340

taaggtggaa aacatatatg ctaaacaaaa gaaacatgat ttttcttcct taaacttgaa     2400

caccaaaaaa acacacacac acacacacgt ggggatagct ggacatgtca gcatgttaag     2460

taaaaggaga atttatgaaa tagtaatgca attctgatat cttctttcta aaattcaaga     2520

gtgcaatttt gtttcaaata cagtatattg tctattttta aggcctcatc tggtctctgt     2580

tttaataatt tgtttgtcag aagaccctga agtatatacc taggtctttt ttttgaaagt     2640

ctctaaattc agaatcattt tttaatttaa agttctacaa ataattgtta ctgcaaacat     2700

tttattttaa aacgttgata gactgatatt tcttggaaga aaatataaaa tatcaaacac     2760

tggttatcac ttgtgatagg aaagagaata ttcaacctgt tgttatttct cgttagaaat     2820

gtaaaccttc aaatatctgt cgtagttaat gacacgactt cacaattctg aacggagcct     2880

cgctcatgga tgctgtgcat cattttcaga tttataattg ttttcaccct aaaatagggc     2940

atccgttgaa ctttggagtt ctaaacaaaa tcctgtaggt gtttggattc tgccccatgt     3000

gttcggacga gctctctgtt gctgacagca ccggccttcg gtctccatgt caggggtggg     3060

cgggtgactg ctgagggagg cccgcaggtg tgtttctcca tcccgtcatc ttgctgcatg     3120

ccgtcaacgg tctccgaaag caacgttgtg cgtagagctg gtggcatacg gcccacgtgc     3180

cttagatggg acatgctgct tctccaccct gggtttgcat tgagcatcat tctagaaagt     3240

gctagtttaa ccagactttt ctctccacca ctagatcttt gtctctacaa gggccctcag     3300

acacctctgc acctgctgag gggaagccag gctccaccgt cggcttctgg agcctccgct     3360

gcttaattac cacagattcc aaatctctag gccccacgag tgagccgcct ggtccaagta     3420

cggcctggtc ccaccctgag ggaggcaggt gtggaacaga agccgagcct ctccgtgtcc     3480

ccaccggggc cgtgggcacc cccacagccc gaagcagaac cctctgagca ttccagagac     3540

cgctgctcgg gggcctgccc aggctgacca acgggcgctc ctgaccacca ccctggcggg     3600

aagggtggcc acggggcccg tcgtcccagc ctgtgcctgc ccagatggca ttttctcaac     3660

tcactgttta ctgtctctca gtgtccaact gtgattagaa gcctggagcc tgccccctgc     3720

accccttttg ctatgcacca cgcttcatgg tgctcttacc actgatgggt gctacacgcg     3780

acgggtgctt cttaggcaaa accaatgtgt gcgaactgtc acacctgtgc cactcgccca     3840

caagccgcgc ccacaattgg ccagctgggc cgtgcacgtc agactgcctg cctcggctct     3900

ccccgtggcc gcgcggggac agcttggtgg gtgcccggtg gcccacctgt ctctggtgct     3960

gccatctgtc ctgggtgtgc cttcgcccca gtgcctgctg gaagtgccct ccgtcgcacc     4020

cctgtgccct gagctcccgt gaggggcccg ccgcgccctt tcgcggtcga agcgttccgt     4080

tgttcttatc tgcctttcct ttccccgctc tcctgggatt actttggggg aatgagtatc     4140

cttggttctg ccctgtgagg gagtcgtgtg tccctgctca taaaggaagg acttcctgca     4200

gaagctgcgg aaaactactg ttccctcgaa ggtgtccccc acctgaggcc tgtcccctac     4260

ctgccctcag gtagttttcc tgaggccagg ggttaacaac agggacatcc ctgcaacttc     4320

cccttcacaa aatgtataat attagatgaa ggatatgcaa catcttggtc tagtaagaac     4380

cgtttcctcc cctctgggtt gaagtcctgg tgtggccccc agaagcagca gtgcgtgtca     4440

ctgggacgtc tccagtagcc cttcccaggc agacgctcct ggcgggacgc catggggccc     4500

acctgagggt cccacagacg taacctgagt gacaggagtc cttgaggatg ggatggccta     4560

tgtcacacac tttgtccttg aacctgagtg atgggggtcc ttgaggatgg gatggcctgt     4620

gtcacgcgct ttgtctttgt gtttggttgt atcggggtct ctgttctgag tgtgtcttcc     4680

tctcatgtac tcaacacagt gggcagcagc ctgggacggc gtcccctctc ccggcggcgg     4740

gcaagccttg cgctgctcca ccctcggcct gggcaccctc acttggcgct ggccacctgg     4800

gccagcctgg ggccatggtc tctctgcagc tgaggcccag tggccccttg ggcagtgatc     4860

ggccctcccc gcatcacagg gccctggcag caagcgggaa atgggggcgc acactgtgtg     4920

cttgggggtg ctgcttgttt accacacatg accagactcc cagcaggaca gagctgctca     4980

gtactttaca gaaaccaact gagtcgtttg tgcatgaatt aagccggtct gcttccccgt     5040

caccttcgta acaaaacaac gtcccctctc ccctcgcctc gagcagtttc ttcaggacac     5100

cgtggctcgg gctgctccct gctgccaggc acgctggttg gctggcctgg gcccggctca     5160

cgtgaagggc actggctctt gtgaccacac tgagccacgt gcaagccgca gccgggcctg     5220

gaagcctgac cctctggttc tagggcttgt cccgcggagc ctgcagagct agacgttggg     5280

gtgtgtccgt gatgatatgg gggccaggct gggagtaggg cctttctagc agggttgggt     5340

ggctcagtga gggtgtggaa gtgggggacc cacggggcct ggctttggga ctagacatgc     5400

cagccccagc tgggctggag ggagcctgag tgagccccga catacgctgg gcctttcagc     5460

tcgccgtgct ctggtgacac acaggcggcc aggttgggat ttgtgtcaat tctaggagcc     5520

atcaagcatg aatgtggttc tgtctcctga gcgcaagcct cgccggaccc ctgggcgaag     5580

gcctggactt gcagatgtgt gttccctgtg cgggtggaca gagggggccc ttatgaccca     5640

cattgcagcc ccattccacc accccttcct ccccagagca gtctctgccg agggacagca     5700

cctgtgtccc ttcgatgcca caacagccag ttgaacaggg gagccctttg ctcaggcagc     5760

ttctcctgcc tctccctcct ttctccttcc ctgccccatc cccgtgccct tcttggcctg     5820

tggcgctggg gagccatggt gtggcatact ggggctcctg ctccttgggc cacttcctca     5880

gcccgggccc cacaggccca ccacctgcca gggctcccac tgcactggct gtggcaggag     5940

gcttccccat gaccccgtgt ggcccagctc ggtgaggatg cagttctagg cacagcccct     6000

gggacagcca gctgcctccc agaccacgtc agcctgctcc agggtcctca gtcaccctgg     6060

gccaggggcc acgtgtccca tggatgtcga ccatgccaac gtcacattcc agcacccctt     6120

ttgcttgatg gcgtctggtg gtagtcagca tggtggaccc acatcctaca gccagaggtg     6180

atgttggaca aaggaagggg agtctggatg ggtccttaaa cgaccattct gtccgcagcg     6240

gggtcattcc ttgtcagccc aagggagggc cggggagtac actgatccca acagctgggc     6300

tgacacctcc tttctcccct gcacggggag gattggcctg aggaccgtca ccctgtgcac     6360

agccccagta gggtggcagt gccactgtct ccttgggccg ttgcaggatt gggcgggtgc     6420

agactcccct tgcgggcccc ttgctcaatc cccggccctc ccagactcct ccctctactg     6480

ggggtaattt gtgtgtcaga agggctctgg cagagctgta aaatactgtt ttttaaaaat     6540

tttagtccag atctttactt attagactgc agaaggagag ctagggagag tgggggaagc     6600

ccccttgctt ttgtatctgt gaggtgaatg agggtctgtc acccaaatct acttctcagc     6660

ccatgaccat agttctgttt tccgtttgca aatctcagta gctctgtttt ctccaaagta     6720

gaatgtgcgc accggggtcc tagccaggcg aggtcagtgt cggcaggcta cctggtcatt     6780

attgctgcct cgtccaggct gatgctgatg gtcacaggca cggtggcatc agggagccgg     6840

gccagcaggc ggcgtgaggc ggggccagca gctcactgca agggcatttt ccacctgatc     6900

ctggtgtgcc ccacatgcgg tggcagggca gacgtgtgaa gcctcggccg tctcggggct     6960

ggcaggtgtg cgggtgagga ggccccggtg gccaagcaga gcctgcgttt catttctcct     7020

gctgcactgt gtctagtctg tcttgtgaac tctcaccgtg aaaagaggct agaagtccag     7080

gatcgctgta ccgctcctgt aattaggtga tgactggatt tgacaactta gtcccctcag     7140

acaagtaaga taccctccaa cagcaaattc aatgacttaa ttggaaaaca cacaagctgg     7200

catgatgtcc ggtgatttct gtaagaaatg cctgtaggag aaggtctgtg aagtgtggag     7260

ggcagtgtcg acgctgcaca gcatctgcag attcgcagcc tcttctctgc cggtgcctct     7320

gttcggttct gttacccaaa aacaaagacc aaagaaggcc aatctctcat ttgaccctgt     7380

ctttttaatc tgcctgtttt aaaagttgcg tctgtagtag ccgcttgctg tgaagacaca     7440

tcttgacagt ccaagtgatt ttgtgaccag tgatttgggt cctgttttcc gctcttctaa     7500

gaaaaaacaa aaagaccgtg agttattgcc cagcaataat catgttgtta ctgtgagtta     7560

gcaacatgcc tgacttcctg atagcattac tgttttctag ttttgtttat tgtatattat     7620

gtgtggtttt atttggtatt tatttgtgtt ttgaggtctt gcaatgtttt tgtgtttctg     7680

atgctaataa ctaaagtttg taagactgta gaatgcaaaa ctcggagatg ctaaactgtc     7740

ttattagagg aaaataaatc tgattatgga gtctcaaaaa aaaaaaaaaa aaa            7793


<210>  20
<211>  7654
<212>  DNA
<213>  Homo sapiens

<400>  20
gggagcgcgg cgcggccgcc gcgtgcgcga gccggggttg cagcccagcc gggactttcc       60

agccggcggc agccgcggcg gccgccggct cttccccgcc ccccgccatg gggcagcccg      120

gggagcagaa cgctgcggac cgcggcggag gacgcgcccg gcgcccctga gccggccgag      180

cggcgacgga ccgcgagaac tcctctttcc taaaatggag tcgagtaaaa agatggactc      240

tcctggcgcg ctgcagacta acccgccgct aaagctgcac actgaccgca gtgctgggac      300

gccagttttt gtccctgaac aaggaggtta caaggaaaag tttgtgaaga ccgtggagga      360

caagtacaag tgtgagaagt gccacctggt gctgtgcagc ccgaagcaga ccgagtgtgg      420

gcaccgcttc tgcgagagct gcatggcggc cctgctgagc tcttcaagtc caaaatgtac      480

agcgtgtcaa gagagcatcg ttaaagataa ggtgtttaag gataattgct gcaagagaga      540

aattctggct cttcagatct attgtcggaa tgaaagcaga ggttgtgcag agcagttaat      600

gctgggacat ctgctggtgc atttaaaaaa tgattgccat tttgaagaac ttccatgtgt      660

gcgtcctgac tgcaaagaaa aggtcttgag gaaagacctg cgagaccacg tggagaaggc      720

gtgtaaatac cgggaagcca catgcagcca ctgcaagagt caggttccga tgatcgcgct      780

gcagaaacac gaagacaccg actgtccctg cgtggtggtg tcctgccctc acaagtgcag      840

cgtccagact ctcctgagga gcgagttgag tgcacacttg tcagagtgtg tcaatgcccc      900

cagcacctgt agttttaagc gctatggctg cgtttttcag gggacaaacc agcagatcaa      960

ggcccacgag gccagctccg ccgtgcagca cgtcaacctg ctgaaggagt ggagcaactc     1020

gctcgaaaag aaggtttcct tgttgcagaa tgaaagtgta gaaaaaaaca agagcataca     1080

aagtttgcac aatcagatat gtagctttga aattgaaatt gagagacaaa aggaaatgct     1140

tcgaaataat gaatccaaaa tccttcattt acagcgagtg atagacagcc aagcagagaa     1200

actgaaggag cttgacaagg agatccggcc cttccggcag aactgggagg aagcagacag     1260

catgaagagc agcgtggagt ccctccagaa ccgcgtgacc gagctggaga gcgtggacaa     1320

gagcgcgggg caagtggctc ggaacacagg cctgctggag tcccagctga gccggcatga     1380

ccagatgctg agtgtgcacg acatccgcct agccgacatg gacctgcgct tccaggtcct     1440

ggagaccgcc agctacaatg gagtgctcat ctggaagatt cgcgactaca agcggcggaa     1500

gcaggaggcc gtcatgggga agaccctgtc cctttacagc cagcctttct acactggtta     1560

ctttggctat aagatgtgtg ccagggtcta cctgaacggg gacgggatgg ggaaggggac     1620

gcacttgtcg ctgttttttg tcatcatgcg tggagaatat gatgccctgc ttccttggcc     1680

gtttaagcag aaagtgacac tcatgctgat ggatcagggg tcctctcgac gtcatttggg     1740

agatgcattc aagcccgacc ccaacagcag cagcttcaag aagcccactg gagagatgaa     1800

tatcgcctct ggctgcccag tctttgtggc ccaaactgtt ctagaaaatg ggacatatat     1860

taaagatgat acaattttta ttaaagtcat agtggatact tcggatctgc ccgatccctg     1920

ataagtagct ggggaggtgg atttagcaga aggcaactcc tctgggggat ttgaaccggt     1980

ctgtcttcac tgaggtcctc gcgctcagaa aaggaccttg tgagacggag gaagcggcag     2040

aaggcggacg cgtgccggcg ggaggagcca cgcgtgagca cacctgacac gttttataat     2100

agactagcca cacttcactc tgaagaatta tttatccttc aacaagataa atattgctgt     2160

cagagaaggt tttcattttc atttttaaag atctagttaa ttaaggtgga aaacatatat     2220

gctaaacaaa agaaacatga tttttcttcc ttaaacttga acaccaaaaa aacacacaca     2280

cacacacacg tggggatagc tggacatgtc agcatgttaa gtaaaaggag aatttatgaa     2340

atagtaatgc aattctgata tcttctttct aaaattcaag agtgcaattt tgtttcaaat     2400

acagtatatt gtctattttt aaggcctcat ctggtctctg ttttaataat ttgtttgtca     2460

gaagaccctg aagtatatac ctaggtcttt tttttgaaag tctctaaatt cagaatcatt     2520

ttttaattta aagttctaca aataattgtt actgcaaaca ttttatttta aaacgttgat     2580

agactgatat ttcttggaag aaaatataaa atatcaaaca ctggttatca cttgtgatag     2640

gaaagagaat attcaacctg ttgttatttc tcgttagaaa tgtaaacctt caaatatctg     2700

tcgtagttaa tgacacgact tcacaattct gaacggagcc tcgctcatgg atgctgtgca     2760

tcattttcag atttataatt gttttcaccc taaaataggg catccgttga actttggagt     2820

tctaaacaaa atcctgtagg tgtttggatt ctgccccatg tgttcggacg agctctctgt     2880

tgctgacagc accggccttc ggtctccatg tcaggggtgg gcgggtgact gctgagggag     2940

gcccgcaggt gtgtttctcc atcccgtcat cttgctgcat gccgtcaacg gtctccgaaa     3000

gcaacgttgt gcgtagagct ggtggcatac ggcccacgtg ccttagatgg gacatgctgc     3060

ttctccaccc tgggtttgca ttgagcatca ttctagaaag tgctagttta accagacttt     3120

tctctccacc actagatctt tgtctctaca agggccctca gacacctctg cacctgctga     3180

ggggaagcca ggctccaccg tcggcttctg gagcctccgc tgcttaatta ccacagattc     3240

caaatctcta ggccccacga gtgagccgcc tggtccaagt acggcctggt cccaccctga     3300

gggaggcagg tgtggaacag aagccgagcc tctccgtgtc cccaccgggg ccgtgggcac     3360

ccccacagcc cgaagcagaa ccctctgagc attccagaga ccgctgctcg ggggcctgcc     3420

caggctgacc aacgggcgct cctgaccacc accctggcgg gaagggtggc cacggggccc     3480

gtcgtcccag cctgtgcctg cccagatggc attttctcaa ctcactgttt actgtctctc     3540

agtgtccaac tgtgattaga agcctggagc ctgccccctg cacccctttt gctatgcacc     3600

acgcttcatg gtgctcttac cactgatggg tgctacacgc gacgggtgct tcttaggcaa     3660

aaccaatgtg tgcgaactgt cacacctgtg ccactcgccc acaagccgcg cccacaattg     3720

gccagctggg ccgtgcacgt cagactgcct gcctcggctc tccccgtggc cgcgcgggga     3780

cagcttggtg ggtgcccggt ggcccacctg tctctggtgc tgccatctgt cctgggtgtg     3840

ccttcgcccc agtgcctgct ggaagtgccc tccgtcgcac ccctgtgccc tgagctcccg     3900

tgaggggccc gccgcgccct ttcgcggtcg aagcgttccg ttgttcttat ctgcctttcc     3960

tttccccgct ctcctgggat tactttgggg gaatgagtat ccttggttct gccctgtgag     4020

ggagtcgtgt gtccctgctc ataaaggaag gacttcctgc agaagctgcg gaaaactact     4080

gttccctcga aggtgtcccc cacctgaggc ctgtccccta cctgccctca ggtagttttc     4140

ctgaggccag gggttaacaa cagggacatc cctgcaactt ccccttcaca aaatgtataa     4200

tattagatga aggatatgca acatcttggt ctagtaagaa ccgtttcctc ccctctgggt     4260

tgaagtcctg gtgtggcccc cagaagcagc agtgcgtgtc actgggacgt ctccagtagc     4320

ccttcccagg cagacgctcc tggcgggacg ccatggggcc cacctgaggg tcccacagac     4380

gtaacctgag tgacaggagt ccttgaggat gggatggcct atgtcacaca ctttgtcctt     4440

gaacctgagt gatgggggtc cttgaggatg ggatggcctg tgtcacgcgc tttgtctttg     4500

tgtttggttg tatcggggtc tctgttctga gtgtgtcttc ctctcatgta ctcaacacag     4560

tgggcagcag cctgggacgg cgtcccctct cccggcggcg ggcaagcctt gcgctgctcc     4620

accctcggcc tgggcaccct cacttggcgc tggccacctg ggccagcctg gggccatggt     4680

ctctctgcag ctgaggccca gtggcccctt gggcagtgat cggccctccc cgcatcacag     4740

ggccctggca gcaagcggga aatgggggcg cacactgtgt gcttgggggt gctgcttgtt     4800

taccacacat gaccagactc ccagcaggac agagctgctc agtactttac agaaaccaac     4860

tgagtcgttt gtgcatgaat taagccggtc tgcttccccg tcaccttcgt aacaaaacaa     4920

cgtcccctct cccctcgcct cgagcagttt cttcaggaca ccgtggctcg ggctgctccc     4980

tgctgccagg cacgctggtt ggctggcctg ggcccggctc acgtgaaggg cactggctct     5040

tgtgaccaca ctgagccacg tgcaagccgc agccgggcct ggaagcctga ccctctggtt     5100

ctagggcttg tcccgcggag cctgcagagc tagacgttgg ggtgtgtccg tgatgatatg     5160

ggggccaggc tgggagtagg gcctttctag cagggttggg tggctcagtg agggtgtgga     5220

agtgggggac ccacggggcc tggctttggg actagacatg ccagccccag ctgggctgga     5280

gggagcctga gtgagccccg acatacgctg ggcctttcag ctcgccgtgc tctggtgaca     5340

cacaggcggc caggttggga tttgtgtcaa ttctaggagc catcaagcat gaatgtggtt     5400

ctgtctcctg agcgcaagcc tcgccggacc cctgggcgaa ggcctggact tgcagatgtg     5460

tgttccctgt gcgggtggac agagggggcc cttatgaccc acattgcagc cccattccac     5520

caccccttcc tccccagagc agtctctgcc gagggacagc acctgtgtcc cttcgatgcc     5580

acaacagcca gttgaacagg ggagcccttt gctcaggcag cttctcctgc ctctccctcc     5640

tttctccttc cctgccccat ccccgtgccc ttcttggcct gtggcgctgg ggagccatgg     5700

tgtggcatac tggggctcct gctccttggg ccacttcctc agcccgggcc ccacaggccc     5760

accacctgcc agggctccca ctgcactggc tgtggcagga ggcttcccca tgaccccgtg     5820

tggcccagct cggtgaggat gcagttctag gcacagcccc tgggacagcc agctgcctcc     5880

cagaccacgt cagcctgctc cagggtcctc agtcaccctg ggccaggggc cacgtgtccc     5940

atggatgtcg accatgccaa cgtcacattc cagcacccct tttgcttgat ggcgtctggt     6000

ggtagtcagc atggtggacc cacatcctac agccagaggt gatgttggac aaaggaaggg     6060

gagtctggat gggtccttaa acgaccattc tgtccgcagc ggggtcattc cttgtcagcc     6120

caagggaggg ccggggagta cactgatccc aacagctggg ctgacacctc ctttctcccc     6180

tgcacgggga ggattggcct gaggaccgtc accctgtgca cagccccagt agggtggcag     6240

tgccactgtc tccttgggcc gttgcaggat tgggcgggtg cagactcccc ttgcgggccc     6300

cttgctcaat ccccggccct cccagactcc tccctctact gggggtaatt tgtgtgtcag     6360

aagggctctg gcagagctgt aaaatactgt tttttaaaaa ttttagtcca gatctttact     6420

tattagactg cagaaggaga gctagggaga gtgggggaag cccccttgct tttgtatctg     6480

tgaggtgaat gagggtctgt cacccaaatc tacttctcag cccatgacca tagttctgtt     6540

ttccgtttgc aaatctcagt agctctgttt tctccaaagt agaatgtgcg caccggggtc     6600

ctagccaggc gaggtcagtg tcggcaggct acctggtcat tattgctgcc tcgtccaggc     6660

tgatgctgat ggtcacaggc acggtggcat cagggagccg ggccagcagg cggcgtgagg     6720

cggggccagc agctcactgc aagggcattt tccacctgat cctggtgtgc cccacatgcg     6780

gtggcagggc agacgtgtga agcctcggcc gtctcggggc tggcaggtgt gcgggtgagg     6840

aggccccggt ggccaagcag agcctgcgtt tcatttctcc tgctgcactg tgtctagtct     6900

gtcttgtgaa ctctcaccgt gaaaagaggc tagaagtcca ggatcgctgt accgctcctg     6960

taattaggtg atgactggat ttgacaactt agtcccctca gacaagtaag ataccctcca     7020

acagcaaatt caatgactta attggaaaac acacaagctg gcatgatgtc cggtgatttc     7080

tgtaagaaat gcctgtagga gaaggtctgt gaagtgtgga gggcagtgtc gacgctgcac     7140

agcatctgca gattcgcagc ctcttctctg ccggtgcctc tgttcggttc tgttacccaa     7200

aaacaaagac caaagaaggc caatctctca tttgaccctg tctttttaat ctgcctgttt     7260

taaaagttgc gtctgtagta gccgcttgct gtgaagacac atcttgacag tccaagtgat     7320

tttgtgacca gtgatttggg tcctgttttc cgctcttcta agaaaaaaca aaaagaccgt     7380

gagttattgc ccagcaataa tcatgttgtt actgtgagtt agcaacatgc ctgacttcct     7440

gatagcatta ctgttttcta gttttgttta ttgtatatta tgtgtggttt tatttggtat     7500

ttatttgtgt tttgaggtct tgcaatgttt ttgtgtttct gatgctaata actaaagttt     7560

gtaagactgt agaatgcaaa actcggagat gctaaactgt cttattagag gaaaataaat     7620

ctgattatgg agtctcaaaa aaaaaaaaaa aaaa                                 7654


<210>  21
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe 
            20                  25                  30          


Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu 
        35                  40                  45              


Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys 
    50                  55                  60                  


Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val 
                85                  90                  95      


Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala 
            100                 105                 110         


Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu 
        115                 120                 125             


Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu 
    130                 135                 140                 


Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys 
145                 150                 155                 160 


Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr 
                165                 170                 175     


Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Lys His 
            180                 185                 190         


Glu Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys 
        195                 200                 205             


Ser Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu 
    210                 215                 220                 


Cys Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val 
225                 230                 235                 240 


Phe Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala 
                245                 250                 255     


Val Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys 
            260                 265                 270         


Lys Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile 
        275                 280                 285             


Gln Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg 
    290                 295                 300                 


Gln Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln 
305                 310                 315                 320 


Arg Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu 
                325                 330                 335     


Ile Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser 
            340                 345                 350         


Ser Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp 
        355                 360                 365             


Lys Ser Ala Gly Gln Val Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln 
    370                 375                 380                 


Leu Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala 
385                 390                 395                 400 


Asp Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly 
                405                 410                 415     


Val Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala 
            420                 425                 430         


Val Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly 
        435                 440                 445             


Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly 
    450                 455                 460                 


Met Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly 
465                 470                 475                 480 


Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu 
                485                 490                 495     


Met Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe 
            500                 505                 510         


Lys Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met 
        515                 520                 525             


Asn Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu 
    530                 535                 540                 


Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val 
545                 550                 555                 560 


Asp Thr Ser Asp Leu Pro Asp Pro 
                565             


<210>  22
<211>  7718
<212>  DNA
<213>  Homo sapiens

<400>  22
gggagcgcgg cgcggccgcc gcgtgcgcga gccggggttg cagcccagcc gggactttcc       60

agccggcggc agccgcggcg gccgccggct cttccccgcc ccccgccatg gggcagcccg      120

gggagcagaa cgctgcggac cgcggcggag gacgcgcccg gcgcccctga gccggccgag      180

cggcgacgga ccgcgagatg aggaaaatga ggcccaaaga agtgatgcca cttggttaag      240

gtcccagagc aggtcagaat cagacctagg atcagaaacc tggctcctgg ctcctggctc      300

cctactcttc taaggatcgc tgtcctgaca gaagagaact cctctttcct aaaatggagt      360

cgagtaaaaa gatggactct cctggcgcgc tgcagactaa cccgccgcta aagctgcaca      420

ctgaccgcag tgctgggacg ccagtttttg tccctgaaca aggaggttac aaggaaaagt      480

ttgtgaagac cgtggaggac aagtacaagt gtgagaagtg ccacctggtg ctgtgcagcc      540

cgaagcagac cgagtgtggg caccgcttct gcgagagctg catggcggcc ctgctgagct      600

cttcaagtcc aaaatgtaca gcgtgtcaag agagcatcgt taaagataag gtgtttaagg      660

ataattgctg caagagagaa attctggctc ttcagatcta ttgtcggaat gaaagcagag      720

gttgtgcaga gcagttaatg ctgggacatc tgctggtgca tttaaaaaat gattgccatt      780

ttgaagaact tccatgtgtg cgtcctgact gcaaagaaaa ggtcttgagg aaagacctgc      840

gagaccacgt ggagaaggcg tgtaaatacc gggaagccac atgcagccac tgcaagagtc      900

aggttccgat gatcgcgctg cagaaacacg aagacaccga ctgtccctgc gtggtggtgt      960

cctgccctca caagtgcagc gtccagactc tcctgaggag cgaggggaca aaccagcaga     1020

tcaaggccca cgaggccagc tccgccgtgc agcacgtcaa cctgctgaag gagtggagca     1080

actcgctcga aaagaaggtt tccttgttgc agaatgaaag tgtagaaaaa aacaagagca     1140

tacaaagttt gcacaatcag atatgtagct ttgaaattga aattgagaga caaaaggaaa     1200

tgcttcgaaa taatgaatcc aaaatccttc atttacagcg agtgatagac agccaagcag     1260

agaaactgaa ggagcttgac aaggagatcc ggcccttccg gcagaactgg gaggaagcag     1320

acagcatgaa gagcagcgtg gagtccctcc agaaccgcgt gaccgagctg gagagcgtgg     1380

acaagagcgc ggggcaagtg gctcggaaca caggcctgct ggagtcccag ctgagccggc     1440

atgaccagat gctgagtgtg cacgacatcc gcctagccga catggacctg cgcttccagg     1500

tcctggagac cgccagctac aatggagtgc tcatctggaa gattcgcgac tacaagcggc     1560

ggaagcagga ggccgtcatg gggaagaccc tgtcccttta cagccagcct ttctacactg     1620

gttactttgg ctataagatg tgtgccaggg tctacctgaa cggggacggg atggggaagg     1680

ggacgcactt gtcgctgttt tttgtcatca tgcgtggaga atatgatgcc ctgcttcctt     1740

ggccgtttaa gcagaaagtg acactcatgc tgatggatca ggggtcctct cgacgtcatt     1800

tgggagatgc attcaagccc gaccccaaca gcagcagctt caagaagccc actggagaga     1860

tgaatatcgc ctctggctgc ccagtctttg tggcccaaac tgttctagaa aatgggacat     1920

atattaaaga tgatacaatt tttattaaag tcatagtgga tacttcggat ctgcccgatc     1980

cctgataagt agctggggag gtggatttag cagaaggcaa ctcctctggg ggatttgaac     2040

cggtctgtct tcactgaggt cctcgcgctc agaaaaggac cttgtgagac ggaggaagcg     2100

gcagaaggcg gacgcgtgcc ggcgggagga gccacgcgtg agcacacctg acacgtttta     2160

taatagacta gccacacttc actctgaaga attatttatc cttcaacaag ataaatattg     2220

ctgtcagaga aggttttcat tttcattttt aaagatctag ttaattaagg tggaaaacat     2280

atatgctaaa caaaagaaac atgatttttc ttccttaaac ttgaacacca aaaaaacaca     2340

cacacacaca cacgtgggga tagctggaca tgtcagcatg ttaagtaaaa ggagaattta     2400

tgaaatagta atgcaattct gatatcttct ttctaaaatt caagagtgca attttgtttc     2460

aaatacagta tattgtctat ttttaaggcc tcatctggtc tctgttttaa taatttgttt     2520

gtcagaagac cctgaagtat atacctaggt cttttttttg aaagtctcta aattcagaat     2580

cattttttaa tttaaagttc tacaaataat tgttactgca aacattttat tttaaaacgt     2640

tgatagactg atatttcttg gaagaaaata taaaatatca aacactggtt atcacttgtg     2700

ataggaaaga gaatattcaa cctgttgtta tttctcgtta gaaatgtaaa ccttcaaata     2760

tctgtcgtag ttaatgacac gacttcacaa ttctgaacgg agcctcgctc atggatgctg     2820

tgcatcattt tcagatttat aattgttttc accctaaaat agggcatccg ttgaactttg     2880

gagttctaaa caaaatcctg taggtgtttg gattctgccc catgtgttcg gacgagctct     2940

ctgttgctga cagcaccggc cttcggtctc catgtcaggg gtgggcgggt gactgctgag     3000

ggaggcccgc aggtgtgttt ctccatcccg tcatcttgct gcatgccgtc aacggtctcc     3060

gaaagcaacg ttgtgcgtag agctggtggc atacggccca cgtgccttag atgggacatg     3120

ctgcttctcc accctgggtt tgcattgagc atcattctag aaagtgctag tttaaccaga     3180

cttttctctc caccactaga tctttgtctc tacaagggcc ctcagacacc tctgcacctg     3240

ctgaggggaa gccaggctcc accgtcggct tctggagcct ccgctgctta attaccacag     3300

attccaaatc tctaggcccc acgagtgagc cgcctggtcc aagtacggcc tggtcccacc     3360

ctgagggagg caggtgtgga acagaagccg agcctctccg tgtccccacc ggggccgtgg     3420

gcacccccac agcccgaagc agaaccctct gagcattcca gagaccgctg ctcgggggcc     3480

tgcccaggct gaccaacggg cgctcctgac caccaccctg gcgggaaggg tggccacggg     3540

gcccgtcgtc ccagcctgtg cctgcccaga tggcattttc tcaactcact gtttactgtc     3600

tctcagtgtc caactgtgat tagaagcctg gagcctgccc cctgcacccc ttttgctatg     3660

caccacgctt catggtgctc ttaccactga tgggtgctac acgcgacggg tgcttcttag     3720

gcaaaaccaa tgtgtgcgaa ctgtcacacc tgtgccactc gcccacaagc cgcgcccaca     3780

attggccagc tgggccgtgc acgtcagact gcctgcctcg gctctccccg tggccgcgcg     3840

gggacagctt ggtgggtgcc cggtggccca cctgtctctg gtgctgccat ctgtcctggg     3900

tgtgccttcg ccccagtgcc tgctggaagt gccctccgtc gcacccctgt gccctgagct     3960

cccgtgaggg gcccgccgcg ccctttcgcg gtcgaagcgt tccgttgttc ttatctgcct     4020

ttcctttccc cgctctcctg ggattacttt gggggaatga gtatccttgg ttctgccctg     4080

tgagggagtc gtgtgtccct gctcataaag gaaggacttc ctgcagaagc tgcggaaaac     4140

tactgttccc tcgaaggtgt cccccacctg aggcctgtcc cctacctgcc ctcaggtagt     4200

tttcctgagg ccaggggtta acaacaggga catccctgca acttcccctt cacaaaatgt     4260

ataatattag atgaaggata tgcaacatct tggtctagta agaaccgttt cctcccctct     4320

gggttgaagt cctggtgtgg cccccagaag cagcagtgcg tgtcactggg acgtctccag     4380

tagcccttcc caggcagacg ctcctggcgg gacgccatgg ggcccacctg agggtcccac     4440

agacgtaacc tgagtgacag gagtccttga ggatgggatg gcctatgtca cacactttgt     4500

ccttgaacct gagtgatggg ggtccttgag gatgggatgg cctgtgtcac gcgctttgtc     4560

tttgtgtttg gttgtatcgg ggtctctgtt ctgagtgtgt cttcctctca tgtactcaac     4620

acagtgggca gcagcctggg acggcgtccc ctctcccggc ggcgggcaag ccttgcgctg     4680

ctccaccctc ggcctgggca ccctcacttg gcgctggcca cctgggccag cctggggcca     4740

tggtctctct gcagctgagg cccagtggcc ccttgggcag tgatcggccc tccccgcatc     4800

acagggccct ggcagcaagc gggaaatggg ggcgcacact gtgtgcttgg gggtgctgct     4860

tgtttaccac acatgaccag actcccagca ggacagagct gctcagtact ttacagaaac     4920

caactgagtc gtttgtgcat gaattaagcc ggtctgcttc cccgtcacct tcgtaacaaa     4980

acaacgtccc ctctcccctc gcctcgagca gtttcttcag gacaccgtgg ctcgggctgc     5040

tccctgctgc caggcacgct ggttggctgg cctgggcccg gctcacgtga agggcactgg     5100

ctcttgtgac cacactgagc cacgtgcaag ccgcagccgg gcctggaagc ctgaccctct     5160

ggttctaggg cttgtcccgc ggagcctgca gagctagacg ttggggtgtg tccgtgatga     5220

tatgggggcc aggctgggag tagggccttt ctagcagggt tgggtggctc agtgagggtg     5280

tggaagtggg ggacccacgg ggcctggctt tgggactaga catgccagcc ccagctgggc     5340

tggagggagc ctgagtgagc cccgacatac gctgggcctt tcagctcgcc gtgctctggt     5400

gacacacagg cggccaggtt gggatttgtg tcaattctag gagccatcaa gcatgaatgt     5460

ggttctgtct cctgagcgca agcctcgccg gacccctggg cgaaggcctg gacttgcaga     5520

tgtgtgttcc ctgtgcgggt ggacagaggg ggcccttatg acccacattg cagccccatt     5580

ccaccacccc ttcctcccca gagcagtctc tgccgaggga cagcacctgt gtcccttcga     5640

tgccacaaca gccagttgaa caggggagcc ctttgctcag gcagcttctc ctgcctctcc     5700

ctcctttctc cttccctgcc ccatccccgt gcccttcttg gcctgtggcg ctggggagcc     5760

atggtgtggc atactggggc tcctgctcct tgggccactt cctcagcccg ggccccacag     5820

gcccaccacc tgccagggct cccactgcac tggctgtggc aggaggcttc cccatgaccc     5880

cgtgtggccc agctcggtga ggatgcagtt ctaggcacag cccctgggac agccagctgc     5940

ctcccagacc acgtcagcct gctccagggt cctcagtcac cctgggccag gggccacgtg     6000

tcccatggat gtcgaccatg ccaacgtcac attccagcac cccttttgct tgatggcgtc     6060

tggtggtagt cagcatggtg gacccacatc ctacagccag aggtgatgtt ggacaaagga     6120

aggggagtct ggatgggtcc ttaaacgacc attctgtccg cagcggggtc attccttgtc     6180

agcccaaggg agggccgggg agtacactga tcccaacagc tgggctgaca cctcctttct     6240

cccctgcacg gggaggattg gcctgaggac cgtcaccctg tgcacagccc cagtagggtg     6300

gcagtgccac tgtctccttg ggccgttgca ggattgggcg ggtgcagact ccccttgcgg     6360

gccccttgct caatccccgg ccctcccaga ctcctccctc tactgggggt aatttgtgtg     6420

tcagaagggc tctggcagag ctgtaaaata ctgtttttta aaaattttag tccagatctt     6480

tacttattag actgcagaag gagagctagg gagagtgggg gaagccccct tgcttttgta     6540

tctgtgaggt gaatgagggt ctgtcaccca aatctacttc tcagcccatg accatagttc     6600

tgttttccgt ttgcaaatct cagtagctct gttttctcca aagtagaatg tgcgcaccgg     6660

ggtcctagcc aggcgaggtc agtgtcggca ggctacctgg tcattattgc tgcctcgtcc     6720

aggctgatgc tgatggtcac aggcacggtg gcatcaggga gccgggccag caggcggcgt     6780

gaggcggggc cagcagctca ctgcaagggc attttccacc tgatcctggt gtgccccaca     6840

tgcggtggca gggcagacgt gtgaagcctc ggccgtctcg gggctggcag gtgtgcgggt     6900

gaggaggccc cggtggccaa gcagagcctg cgtttcattt ctcctgctgc actgtgtcta     6960

gtctgtcttg tgaactctca ccgtgaaaag aggctagaag tccaggatcg ctgtaccgct     7020

cctgtaatta ggtgatgact ggatttgaca acttagtccc ctcagacaag taagataccc     7080

tccaacagca aattcaatga cttaattgga aaacacacaa gctggcatga tgtccggtga     7140

tttctgtaag aaatgcctgt aggagaaggt ctgtgaagtg tggagggcag tgtcgacgct     7200

gcacagcatc tgcagattcg cagcctcttc tctgccggtg cctctgttcg gttctgttac     7260

ccaaaaacaa agaccaaaga aggccaatct ctcatttgac cctgtctttt taatctgcct     7320

gttttaaaag ttgcgtctgt agtagccgct tgctgtgaag acacatcttg acagtccaag     7380

tgattttgtg accagtgatt tgggtcctgt tttccgctct tctaagaaaa aacaaaaaga     7440

ccgtgagtta ttgcccagca ataatcatgt tgttactgtg agttagcaac atgcctgact     7500

tcctgatagc attactgttt tctagttttg tttattgtat attatgtgtg gttttatttg     7560

gtatttattt gtgttttgag gtcttgcaat gtttttgtgt ttctgatgct aataactaaa     7620

gtttgtaaga ctgtagaatg caaaactcgg agatgctaaa ctgtcttatt agaggaaaat     7680

aaatctgatt atggagtctc aaaaaaaaaa aaaaaaaa                             7718


<210>  23
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe 
            20                  25                  30          


Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu 
        35                  40                  45              


Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys 
    50                  55                  60                  


Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val 
                85                  90                  95      


Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala 
            100                 105                 110         


Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu 
        115                 120                 125             


Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu 
    130                 135                 140                 


Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys 
145                 150                 155                 160 


Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr 
                165                 170                 175     


Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Lys His 
            180                 185                 190         


Glu Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys 
        195                 200                 205             


Ser Val Gln Thr Leu Leu Arg Ser Glu Gly Thr Asn Gln Gln Ile Lys 
    210                 215                 220                 


Ala His Glu Ala Ser Ser Ala Val Gln His Val Asn Leu Leu Lys Glu 
225                 230                 235                 240 


Trp Ser Asn Ser Leu Glu Lys Lys Val Ser Leu Leu Gln Asn Glu Ser 
                245                 250                 255     


Val Glu Lys Asn Lys Ser Ile Gln Ser Leu His Asn Gln Ile Cys Ser 
            260                 265                 270         


Phe Glu Ile Glu Ile Glu Arg Gln Lys Glu Met Leu Arg Asn Asn Glu 
        275                 280                 285             


Ser Lys Ile Leu His Leu Gln Arg Val Ile Asp Ser Gln Ala Glu Lys 
    290                 295                 300                 


Leu Lys Glu Leu Asp Lys Glu Ile Arg Pro Phe Arg Gln Asn Trp Glu 
305                 310                 315                 320 


Glu Ala Asp Ser Met Lys Ser Ser Val Glu Ser Leu Gln Asn Arg Val 
                325                 330                 335     


Thr Glu Leu Glu Ser Val Asp Lys Ser Ala Gly Gln Val Ala Arg Asn 
            340                 345                 350         


Thr Gly Leu Leu Glu Ser Gln Leu Ser Arg His Asp Gln Met Leu Ser 
        355                 360                 365             


Val His Asp Ile Arg Leu Ala Asp Met Asp Leu Arg Phe Gln Val Leu 
    370                 375                 380                 


Glu Thr Ala Ser Tyr Asn Gly Val Leu Ile Trp Lys Ile Arg Asp Tyr 
385                 390                 395                 400 


Lys Arg Arg Lys Gln Glu Ala Val Met Gly Lys Thr Leu Ser Leu Tyr 
                405                 410                 415     


Ser Gln Pro Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met Cys Ala Arg 
            420                 425                 430         


Val Tyr Leu Asn Gly Asp Gly Met Gly Lys Gly Thr His Leu Ser Leu 
        435                 440                 445             


Phe Phe Val Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu Pro Trp Pro 
    450                 455                 460                 


Phe Lys Gln Lys Val Thr Leu Met Leu Met Asp Gln Gly Ser Ser Arg 
465                 470                 475                 480 


Arg His Leu Gly Asp Ala Phe Lys Pro Asp Pro Asn Ser Ser Ser Phe 
                485                 490                 495     


Lys Lys Pro Thr Gly Glu Met Asn Ile Ala Ser Gly Cys Pro Val Phe 
            500                 505                 510         


Val Ala Gln Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys Asp Asp Thr 
        515                 520                 525             


Ile Phe Ile Lys Val Ile Val Asp Thr Ser Asp Leu Pro Asp Pro 
    530                 535                 540             


<210>  24
<211>  7405
<212>  DNA
<213>  Homo sapiens

<400>  24
gggagcgcgg cgcggccgcc gcgtgcgcga gccggggttg cagcccagcc gggactttcc       60

agccggcggc agccgcggcg gccgccggct cttccccgcc ccccgccatg gggcagcccg      120

gggagcagaa cgctgcggac cgcggcggag gacgcgcccg gcgcccctga gccggccgag      180

cggcgacgga ccgcgagaac tcctctttcc taaaatggag tcgagtaaaa agatggactc      240

tcctggcgcg ctgcagacta acccgccgct aaagctgcac actgaccgca gtgctgggac      300

gccagttttt gtccctgaac aaggaggtta caaggaaaag tttgtgaaga ccgtggagga      360

caagtacaag tgtgagaagt gccacctggt gctgtgcagc ccgaagcaga ccgagtgtgg      420

gcaccgcttc tgcgagagct gcatggcggc cctgctgagc tcttcaagtc caaaatgtac      480

agcgtgtcaa gagagcatcg ttaaagataa ggtgtttaag gataattgct gcaagagaga      540

aattctggct cttcagatct attgtcggaa tgaaagcaga ggttgtgcag agcagttaat      600

gctgggacat ctgctggtgc atttaaaaaa tgattgccat tttgaagaac ttccatgtgt      660

gcgtcctgac tgcaaagaaa aggtcttgag gaaagacctg cgagaccacg tggagaaggc      720

gtgtaaatac cgggaagcca catgcagcca ctgcaagagt caggttccga tgatcgcgct      780

gcaggtttcc ttgttgcaga atgaaagtgt agaaaaaaac aagagcatac aaagtttgca      840

caatcagata tgtagctttg aaattgaaat tgagagacaa aaggaaatgc ttcgaaataa      900

tgaatccaaa atccttcatt tacagcgagt gatagacagc caagcagaga aactgaagga      960

gcttgacaag gagatccggc ccttccggca gaactgggag gaagcagaca gcatgaagag     1020

cagcgtggag tccctccaga accgcgtgac cgagctggag agcgtggaca agagcgcggg     1080

gcaagtggct cggaacacag gcctgctgga gtcccagctg agccggcatg accagatgct     1140

gagtgtgcac gacatccgcc tagccgacat ggacctgcgc ttccaggtcc tggagaccgc     1200

cagctacaat ggagtgctca tctggaagat tcgcgactac aagcggcgga agcaggaggc     1260

cgtcatgggg aagaccctgt ccctttacag ccagcctttc tacactggtt actttggcta     1320

taagatgtgt gccagggtct acctgaacgg ggacgggatg gggaagggga cgcacttgtc     1380

gctgtttttt gtcatcatgc gtggagaata tgatgccctg cttccttggc cgtttaagca     1440

gaaagtgaca ctcatgctga tggatcaggg gtcctctcga cgtcatttgg gagatgcatt     1500

caagcccgac cccaacagca gcagcttcaa gaagcccact ggagagatga atatcgcctc     1560

tggctgccca gtctttgtgg cccaaactgt tctagaaaat gggacatata ttaaagatga     1620

tacaattttt attaaagtca tagtggatac ttcggatctg cccgatccct gataagtagc     1680

tggggaggtg gatttagcag aaggcaactc ctctggggga tttgaaccgg tctgtcttca     1740

ctgaggtcct cgcgctcaga aaaggacctt gtgagacgga ggaagcggca gaaggcggac     1800

gcgtgccggc gggaggagcc acgcgtgagc acacctgaca cgttttataa tagactagcc     1860

acacttcact ctgaagaatt atttatcctt caacaagata aatattgctg tcagagaagg     1920

ttttcatttt catttttaaa gatctagtta attaaggtgg aaaacatata tgctaaacaa     1980

aagaaacatg atttttcttc cttaaacttg aacaccaaaa aaacacacac acacacacac     2040

gtggggatag ctggacatgt cagcatgtta agtaaaagga gaatttatga aatagtaatg     2100

caattctgat atcttctttc taaaattcaa gagtgcaatt ttgtttcaaa tacagtatat     2160

tgtctatttt taaggcctca tctggtctct gttttaataa tttgtttgtc agaagaccct     2220

gaagtatata cctaggtctt ttttttgaaa gtctctaaat tcagaatcat tttttaattt     2280

aaagttctac aaataattgt tactgcaaac attttatttt aaaacgttga tagactgata     2340

tttcttggaa gaaaatataa aatatcaaac actggttatc acttgtgata ggaaagagaa     2400

tattcaacct gttgttattt ctcgttagaa atgtaaacct tcaaatatct gtcgtagtta     2460

atgacacgac ttcacaattc tgaacggagc ctcgctcatg gatgctgtgc atcattttca     2520

gatttataat tgttttcacc ctaaaatagg gcatccgttg aactttggag ttctaaacaa     2580

aatcctgtag gtgtttggat tctgccccat gtgttcggac gagctctctg ttgctgacag     2640

caccggcctt cggtctccat gtcaggggtg ggcgggtgac tgctgaggga ggcccgcagg     2700

tgtgtttctc catcccgtca tcttgctgca tgccgtcaac ggtctccgaa agcaacgttg     2760

tgcgtagagc tggtggcata cggcccacgt gccttagatg ggacatgctg cttctccacc     2820

ctgggtttgc attgagcatc attctagaaa gtgctagttt aaccagactt ttctctccac     2880

cactagatct ttgtctctac aagggccctc agacacctct gcacctgctg aggggaagcc     2940

aggctccacc gtcggcttct ggagcctccg ctgcttaatt accacagatt ccaaatctct     3000

aggccccacg agtgagccgc ctggtccaag tacggcctgg tcccaccctg agggaggcag     3060

gtgtggaaca gaagccgagc ctctccgtgt ccccaccggg gccgtgggca cccccacagc     3120

ccgaagcaga accctctgag cattccagag accgctgctc gggggcctgc ccaggctgac     3180

caacgggcgc tcctgaccac caccctggcg ggaagggtgg ccacggggcc cgtcgtccca     3240

gcctgtgcct gcccagatgg cattttctca actcactgtt tactgtctct cagtgtccaa     3300

ctgtgattag aagcctggag cctgccccct gcaccccttt tgctatgcac cacgcttcat     3360

ggtgctctta ccactgatgg gtgctacacg cgacgggtgc ttcttaggca aaaccaatgt     3420

gtgcgaactg tcacacctgt gccactcgcc cacaagccgc gcccacaatt ggccagctgg     3480

gccgtgcacg tcagactgcc tgcctcggct ctccccgtgg ccgcgcgggg acagcttggt     3540

gggtgcccgg tggcccacct gtctctggtg ctgccatctg tcctgggtgt gccttcgccc     3600

cagtgcctgc tggaagtgcc ctccgtcgca cccctgtgcc ctgagctccc gtgaggggcc     3660

cgccgcgccc tttcgcggtc gaagcgttcc gttgttctta tctgcctttc ctttccccgc     3720

tctcctggga ttactttggg ggaatgagta tccttggttc tgccctgtga gggagtcgtg     3780

tgtccctgct cataaaggaa ggacttcctg cagaagctgc ggaaaactac tgttccctcg     3840

aaggtgtccc ccacctgagg cctgtcccct acctgccctc aggtagtttt cctgaggcca     3900

ggggttaaca acagggacat ccctgcaact tccccttcac aaaatgtata atattagatg     3960

aaggatatgc aacatcttgg tctagtaaga accgtttcct cccctctggg ttgaagtcct     4020

ggtgtggccc ccagaagcag cagtgcgtgt cactgggacg tctccagtag cccttcccag     4080

gcagacgctc ctggcgggac gccatggggc ccacctgagg gtcccacaga cgtaacctga     4140

gtgacaggag tccttgagga tgggatggcc tatgtcacac actttgtcct tgaacctgag     4200

tgatgggggt ccttgaggat gggatggcct gtgtcacgcg ctttgtcttt gtgtttggtt     4260

gtatcggggt ctctgttctg agtgtgtctt cctctcatgt actcaacaca gtgggcagca     4320

gcctgggacg gcgtcccctc tcccggcggc gggcaagcct tgcgctgctc caccctcggc     4380

ctgggcaccc tcacttggcg ctggccacct gggccagcct ggggccatgg tctctctgca     4440

gctgaggccc agtggcccct tgggcagtga tcggccctcc ccgcatcaca gggccctggc     4500

agcaagcggg aaatgggggc gcacactgtg tgcttggggg tgctgcttgt ttaccacaca     4560

tgaccagact cccagcagga cagagctgct cagtacttta cagaaaccaa ctgagtcgtt     4620

tgtgcatgaa ttaagccggt ctgcttcccc gtcaccttcg taacaaaaca acgtcccctc     4680

tcccctcgcc tcgagcagtt tcttcaggac accgtggctc gggctgctcc ctgctgccag     4740

gcacgctggt tggctggcct gggcccggct cacgtgaagg gcactggctc ttgtgaccac     4800

actgagccac gtgcaagccg cagccgggcc tggaagcctg accctctggt tctagggctt     4860

gtcccgcgga gcctgcagag ctagacgttg gggtgtgtcc gtgatgatat gggggccagg     4920

ctgggagtag ggcctttcta gcagggttgg gtggctcagt gagggtgtgg aagtggggga     4980

cccacggggc ctggctttgg gactagacat gccagcccca gctgggctgg agggagcctg     5040

agtgagcccc gacatacgct gggcctttca gctcgccgtg ctctggtgac acacaggcgg     5100

ccaggttggg atttgtgtca attctaggag ccatcaagca tgaatgtggt tctgtctcct     5160

gagcgcaagc ctcgccggac ccctgggcga aggcctggac ttgcagatgt gtgttccctg     5220

tgcgggtgga cagagggggc ccttatgacc cacattgcag ccccattcca ccaccccttc     5280

ctccccagag cagtctctgc cgagggacag cacctgtgtc ccttcgatgc cacaacagcc     5340

agttgaacag gggagccctt tgctcaggca gcttctcctg cctctccctc ctttctcctt     5400

ccctgcccca tccccgtgcc cttcttggcc tgtggcgctg gggagccatg gtgtggcata     5460

ctggggctcc tgctccttgg gccacttcct cagcccgggc cccacaggcc caccacctgc     5520

cagggctccc actgcactgg ctgtggcagg aggcttcccc atgaccccgt gtggcccagc     5580

tcggtgagga tgcagttcta ggcacagccc ctgggacagc cagctgcctc ccagaccacg     5640

tcagcctgct ccagggtcct cagtcaccct gggccagggg ccacgtgtcc catggatgtc     5700

gaccatgcca acgtcacatt ccagcacccc ttttgcttga tggcgtctgg tggtagtcag     5760

catggtggac ccacatccta cagccagagg tgatgttgga caaaggaagg ggagtctgga     5820

tgggtcctta aacgaccatt ctgtccgcag cggggtcatt ccttgtcagc ccaagggagg     5880

gccggggagt acactgatcc caacagctgg gctgacacct cctttctccc ctgcacgggg     5940

aggattggcc tgaggaccgt caccctgtgc acagccccag tagggtggca gtgccactgt     6000

ctccttgggc cgttgcagga ttgggcgggt gcagactccc cttgcgggcc ccttgctcaa     6060

tccccggccc tcccagactc ctccctctac tgggggtaat ttgtgtgtca gaagggctct     6120

ggcagagctg taaaatactg ttttttaaaa attttagtcc agatctttac ttattagact     6180

gcagaaggag agctagggag agtgggggaa gcccccttgc ttttgtatct gtgaggtgaa     6240

tgagggtctg tcacccaaat ctacttctca gcccatgacc atagttctgt tttccgtttg     6300

caaatctcag tagctctgtt ttctccaaag tagaatgtgc gcaccggggt cctagccagg     6360

cgaggtcagt gtcggcaggc tacctggtca ttattgctgc ctcgtccagg ctgatgctga     6420

tggtcacagg cacggtggca tcagggagcc gggccagcag gcggcgtgag gcggggccag     6480

cagctcactg caagggcatt ttccacctga tcctggtgtg ccccacatgc ggtggcaggg     6540

cagacgtgtg aagcctcggc cgtctcgggg ctggcaggtg tgcgggtgag gaggccccgg     6600

tggccaagca gagcctgcgt ttcatttctc ctgctgcact gtgtctagtc tgtcttgtga     6660

actctcaccg tgaaaagagg ctagaagtcc aggatcgctg taccgctcct gtaattaggt     6720

gatgactgga tttgacaact tagtcccctc agacaagtaa gataccctcc aacagcaaat     6780

tcaatgactt aattggaaaa cacacaagct ggcatgatgt ccggtgattt ctgtaagaaa     6840

tgcctgtagg agaaggtctg tgaagtgtgg agggcagtgt cgacgctgca cagcatctgc     6900

agattcgcag cctcttctct gccggtgcct ctgttcggtt ctgttaccca aaaacaaaga     6960

ccaaagaagg ccaatctctc atttgaccct gtctttttaa tctgcctgtt ttaaaagttg     7020

cgtctgtagt agccgcttgc tgtgaagaca catcttgaca gtccaagtga ttttgtgacc     7080

agtgatttgg gtcctgtttt ccgctcttct aagaaaaaac aaaaagaccg tgagttattg     7140

cccagcaata atcatgttgt tactgtgagt tagcaacatg cctgacttcc tgatagcatt     7200

actgttttct agttttgttt attgtatatt atgtgtggtt ttatttggta tttatttgtg     7260

ttttgaggtc ttgcaatgtt tttgtgtttc tgatgctaat aactaaagtt tgtaagactg     7320

tagaatgcaa aactcggaga tgctaaactg tcttattaga ggaaaataaa tctgattatg     7380

gagtctcaaa aaaaaaaaaa aaaaa                                           7405


<210>  25
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe 
            20                  25                  30          


Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu 
        35                  40                  45              


Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys 
    50                  55                  60                  


Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val 
                85                  90                  95      


Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala 
            100                 105                 110         


Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu 
        115                 120                 125             


Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu 
    130                 135                 140                 


Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys 
145                 150                 155                 160 


Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr 
                165                 170                 175     


Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Val Ser 
            180                 185                 190         


Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile Gln Ser Leu 
        195                 200                 205             


His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg Gln Lys Glu 
    210                 215                 220                 


Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln Arg Val Ile 
225                 230                 235                 240 


Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu Ile Arg Pro 
                245                 250                 255     


Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser Ser Val Glu 
            260                 265                 270         


Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp Lys Ser Ala 
        275                 280                 285             


Gly Gln Val Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln Leu Ser Arg 
    290                 295                 300                 


His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala Asp Met Asp 
305                 310                 315                 320 


Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly Val Leu Ile 
                325                 330                 335     


Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala Val Met Gly 
            340                 345                 350         


Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr Phe Gly 
        355                 360                 365             


Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met Gly Lys 
    370                 375                 380                 


Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu Tyr Asp 
385                 390                 395                 400 


Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu Met Leu Met 
                405                 410                 415     


Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe Lys Pro Asp 
            420                 425                 430         


Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met Asn Ile Ala 
        435                 440                 445             


Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu Asn Gly Thr 
    450                 455                 460                 


Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val Asp Thr Ser 
465                 470                 475                 480 


Asp Leu Pro Asp Pro 
                485 


<210>  26
<211>  7164
<212>  DNA
<213>  Mus musculus

<400>  26
agcgcgcgag aggaagtgcc agcgcgaggg tgcgtgaggc ggcgcggccg gcggccgccg       60

cgtgcgcgag ccgggttgca gcccagcagg gactttccag ccggcggcgg cggcggcggc      120

cgccggccct tccccgcccc ccgacatggg gctgcccggg gagctggacg ctgcagaagg      180

cggcggagga tgcgcgcggc gcccctgagc cggccgaacg ggcgggcctc ggggtacagg      240

gtccccatta cttgaaggat aaggctggca cggctccgac gtctgtgtgg aagcttctcc      300

ctcccttctg agcttctcta gactccttac agcgcacggc acagaatttc agtttcctaa      360

gatggagtca agcaaaaaga tggatgctgc tggcacactg cagcctaacc cacccctaaa      420

gctgcagcct gatcgcggcg cagggtccgt gctcgtgccg gagcaaggag gctacaagga      480

gaagtttgtg aagacggtgg aagacaagta caagtgcgag aagtgccgcc tggtgctgtg      540

caacccgaag cagacggagt gtggccaccg gttctgcgag agctgcatgg ccgccctgct      600

gagctcctcc agtccaaaat gcacagcgtg ccaagaaagc atcatcaaag acaaggtgtt      660

taaggataat tgctgcaaga gagagattct ggcccttcag gtctactgtc ggaatgaagg      720

cagaggttgt gcggagcagc tgactctggg acatctgctg gtgcacctaa aaaatgaatg      780

tcagtttgag gaacttccct gtctgcgtgc cgactgcaaa gaaaaagtac tgagaaaaga      840

cttgcgggat cacgtggaaa aggcctgtaa ataccgcgag gccacgtgca gtcactgcaa      900

gagccaagtg cccatgatca aactgcagaa acatgaagac acagattgtc cctgtgtggt      960

ggtatcctgc cctcacaagt gcagcgttca gactcttcta aggagtgagt tgagtgcaca     1020

cttgtccgag tgtgtcaatg cccccagcac ctgtagtttt aagcgctatg gctgcgtttt     1080

tcagggtaca aaccagcaga tcaaggccca tgaggccagc tccgcggtac agcacgtgaa     1140

cctgctgaag gagtggagca actccctgga gaagaaggtt tccctgctgc agaatgaaag     1200

tgttgagaaa aacaagagca tccaaagcct gcacaaccag atctgcagct ttgagatcga     1260

gattgagagg cagaaggaga tgctccgaaa caacgagtcc aagatccttc acctgcagcg     1320

ggtaatcgac agccaagcag agaaactgaa agaactggac aaggagatcc gtcccttccg     1380

gcagaactgg gaggaagcgg acagcatgaa gagcagtgtg gagtccctcc agaaccgagt     1440

gactgagctg gagagcgtag acaaaagtgc ggggcaggcg gctcgcaaca caggcttgct     1500

ggagtcccag ctgagccggc atgaccagat gttgagtgtt catgacatcc gcttggccga     1560

catggacctg cggttccagg tcctcgagac cgccagctac aacggggtgc tgatctggaa     1620

gatccgtgac tacaagcgcc ggaagcagga ggccgtcatg gggaagaccc tgtctctcta     1680

cagccagcct ttctacacag gttattttgg ctataagatg tgtgccaggg tctacctgaa     1740

tggggacgga atggggaaag ggacacactt gtcgctgttt tttgtcatta tgcgtggaga     1800

atatgatgct ctgttgccat ggccgttcaa gcagaaagtg acacttatgc tgatggatca     1860

ggggtcctct cgccgtcatc tgggagatgc gttcaagcct gaccccaaca gcagcagctt     1920

caagaaaccc accggagaga tgaatatcgc ctctggctgc ccagtctttg tcgcccaaac     1980

tgttctagag aacgggacgt atattaaaga tgatacaatc tttattaagg tcatagtgga     2040

tacctcggat ctgcctgacc cctgacaaga aagcagggcg gtggattcag cagaaggtaa     2100

ctcctctggg ggggtgagct agtgtcttca cggaggtcct cgccctcaga aaggaccttg     2160

tgggacagag gaagcagccg gaggaggaga aggaggtcga gtggctggca ggagagccac     2220

atgtgaaaac agaccccaac ggattttcta atagactagc cacacccact ctgaaggatt     2280

atttatccat caacaagata aatactgctg tcagagaagg ttttcatttt cattttaaaa     2340

gatctagtta attaaggtgg gaacatatat gctaaaaaga aacatgattt ttcttcctta     2400

acttaaacac caaaaagaga acacatgtgg gggtagctgg atgtgtcagc atgttaacct     2460

acgaggagaa cttatgaaat cataacacaa tccccatata ctcatcctaa aattcaagag     2520

tgcaatcttg tttcaaatat agtatattgt ctatttttaa ggcctcatct ggtctctgtt     2580

ttaataattt gtttgtcaga agaccctgag taggcagaag gtctctaaat tcagaagtca     2640

tttttaattt aaagttctac aaataattgt tactgcaaac attttgtttt aaaacgttga     2700

tagactgata tttcttggaa gaaaatgtaa aatatcaaac actggttatc acttgtgata     2760

ggaaagagaa tattgaacct gctgttattt ctcgttagaa atgtaaccct tcgatatctg     2820

tcgtagttag tgacactact tcacaatgac tatgagaggg acaatgctca tggatgctgt     2880

gcatcatttc agacttaaca attgttttca ccctaaaata gggcattagt tgaactttgg     2940

agttctaaac aaaatcctat aggtttttac aattctgccc catgtttaga caagctctgt     3000

tgctgacagc accagccttg gtctccagtg tcggtgtccg gggataggca ggtgacccgt     3060

gccgcaggca ggaggcccca gcgagcatcc catcctgtca tactgctgca tccggctagc     3120

gcgctccgaa agcaacatcc gtgctcagag atggtggcat acggtacttg tgccttagat     3180

gtgacatgct gcttcttgtc cctgggtttg cgttcaccat ggttctagaa agtgtcagtt     3240

taaccagatc tctctccacc accagaactt tgtctctgcc agggccctca ggcaactctg     3300

aacctgcctg gggatgccag gcctccattg gcagctcttg aagcctctgc tgctaaatat     3360

tcacagattc caaccgtagg cccctaagag cagctcagtc ccactccaag ggagggaggt     3420

gtgagcagaa gccacaccct tccaggtctc tgcaagggcc ctgaaatccc cacagcatga     3480

aggagaagtg ccctagtccc aagcgttccc gagaccactg gtctggggcc tgcccgggct     3540

ggcagcagca accctggcct ccctgtgagg agggcagcca gctgatgccc agcctgtgag     3600

tgcagaggcc cgccctctca gctcactgtt cccactgtga tgagaagcct ggagccctgc     3660

cccggtgccc cttttgctat gcaccacact tcacggtgct ctacactgat gggtgctaca     3720

cgcgacaggt gcttcttagg caaaaccaat gtgtgcaaac caccacatct gtgccacttg     3780

cccaaaaggc gcgcccacaa ttggccagct gggcctgcgc ttcagactgc ctgcctctgg     3840

gctctcccca tggtcgcacg gggacagctg ggttggtgcc cggtagccca ccttgtctct     3900

ggtgctgcca tctgtcctgg gtgtgccttc gccccagtgc ctgctggaag tgccctcctc     3960

tcgcacacct gtccccgtgc ttccatgagc gacctcttgg tttcgagcac tcaccctgcc     4020

cttccatggc tgaagcgttt ggtttgtcct ctgctccccg cttctctcca ttatgctggg     4080

attgctttgg ggtaagtcag caaccttggt tctgcccaca aggaaagacc gcagagctca     4140

agttctttca aaggtgccct cctcttcctc taggcctgtc accagggttc ctcccccaaa     4200

gacctggagt tggggggaac acccagcagt ccttggctgg cttcaggaag cttttctgtg     4260

gccagatgtc agcaacgggg ccatccctgt agctcccccc ttcagagaaa tcagtgcagt     4320

atcaacaggt gtaggccagc agcatcgtgt ctgacaaaaa gcatgtctgt ccttagtttc     4380

agacccttgt atgagggtga ccctgacatg tcctcgggcc cgtcctccct tttagtgaga     4440

cttggtcaag gctccttcct atgcgaggtg gccctcctgg cttcccccgt gcctgtaggg     4500

tgtgtgtaaa gtaagtgact gctcccctgg gatgagggcc ctgaacaatg tcacagcttc     4560

ctgtagtgtg ttgtgtctat tgcatttctc ggtaactgta gaatagtggg caagcttgcc     4620

cctctgtgcc ctgtctcagt gtgtgaaggg catctcctgg gaggtgtgga gcaggctgcg     4680

tcctgcctgg gtgtgccttg ctctgctcca tctcagcatt ccttggtgct caccacccgg     4740

gggtgtgggg cattgttggg ctgtggtctc agcatagctg tggctaccag tcctagcagc     4800

tagccctcac catatcacag ggtcctggcc atgagaagta tggggtgtca tgcggcgtgt     4860

gtacctggct gtgcaaaagt gtcaagtgct catcttttaa gaggccggta gttgcatggc     4920

ctctgtgggg aaattggata caactcctgc ttgccggggt ggtgtttgta cctgctcaca     4980

gctgaccctg ggaagatggc agccactaac tagcagtgtg tcctgaggcc cagcctgcag     5040

ttttttgtga atagctgaaa gcttgtgtca gtaacaaccc agggccttcc accttcgttg     5100

gtcagggaga agaaggtagc ctggggtgcc ctggccgagc ctccttcacc tcttggggat     5160

agacagagcc agcggaggcc acacatgtag gccgcgtgtg agagggatgg gtgagactgt     5220

gaatgagtgt aacacactga gtgtgagctg ggctcacaca ggagagcaga gcccatgccc     5280

agcattccag gaagcaaagg gctgtgagag ggtccgcatc ctcttccttt ctaaagtagc     5340

ctgtgcacag atggcgccat gtccctaaga cagcacaaca gtcagacagc acagccatga     5400

gctgagggag gtgtctgctt acagccaccg tccgcctcct ttctttctct gctcttttcc     5460

cgtttattcc aaggactggg cagcctccag cagggccttc agacccaccc ccaccagatc     5520

cctttgaaat atgtggtcag cctcatgaga acctagctgt cagccccctg tggatagcta     5580

gccaccttcc catccctcct tagtcagccc ctgtcccacc aggagttggg acctcatgcc     5640

tgctatcttg ggcctgacat taactgaaca gtatacatag cagtcaccca cggcagacct     5700

ggcaaccagt ggacagcatc cagcaaagat gaggatgtct gggcacgcca agtaacgggg     5760

tcctaggtgg accactcctg ccggcccaag aggagaccag ggggagtgcc agggtcagca     5820

gcatggccct tgctgcccct ccccctgtgc actgccatgc attgcaggga cttttgtacc     5880

tggccaaggc atttcccccg acaggtgaca gggttggtca gtcctcactc tcccatacat     5940

ccctctgctt gggagcatca gtgaatagag aagggcttga tggtgcttag gggactattt     6000

ttttactttc aatccagaag agctagtgtg ggcttcatgc catcatgtcc tgagtgtgtg     6060

tgacaaatga gggtctgact ctcgaatctc ctcagaccaa gactctatct tctatttgca     6120

cacccatagc agctgttttc tccaagctca aatgtgccca cgggggtctg atcaggtgag     6180

gtgatcattg gcaagtgacc cagccgttgc cagctctccc accccggctg ctgctgctag     6240

ccacgaggac tgtggcgtcc aggagcccat cccccaacct ggacctatcc tagcctgttg     6300

tctgcttggg caccattact aggtaggcag gcaaggcagt gacccacacc aaagccagcc     6360

ctacagctga gcatgcccca gcacccaagc agcgggtatg atccaattcc ctaaccgcac     6420

cacgtctgga gtctgtcctg tgagctcact gtggaaagga ggttacaagc ccaggtcact     6480

gtgccactcc atagtcagtg gcgaccagcg tgcaccccta atccccttag tcacttaaga     6540

aaaccttcaa aggcaaataa atgacctaat tggaaaacac aaaagccggc cttcctccca     6600

aggattccct aagaatctgt gggcgctctg actgagtagg ttggggtcag tgcagacagc     6660

tgcagactgt tctaaagttc cgttcttatc tctgatggca cacctctcgt gttcagttct     6720

attacccaaa aaacaaagac caaagaaggc caatctctca tttgaccgta tttttaatct     6780

gcctgttttg acacatgccg tctgtagtaa ccgctcgctg tgaggcccca tcttgacagt     6840

ccaagtgatc gtgaccagtg attagcgtcc cgtgttctaa tgctcttcta agaaactgag     6900

acagtgtgaa ttattgctca gcaataatca tgtcaccagg agttagcagc acgcctcatc     6960

tcctgatagc attatgatgt ttcgtgtttt gtttaccgtg tgttacatgt aaggtttcat     7020

ttggtattta tttgtgtttt gaggtcttgc gatgtttctg ttctgctgct aataataaag     7080

tttgtaagac tgtagaatgc agaattttgt aatgctcaag tgtctattag aggaaaataa     7140

agctgattca agagtccggc aaaa                                            7164


<210>  27
<211>  567
<212>  PRT
<213>  Mus musculus

<400>  27

Met Glu Ser Ser Lys Lys Met Asp Ala Ala Gly Thr Leu Gln Pro Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu Gln Pro Asp Arg Gly Ala Gly Ser Val Leu Val 
            20                  25                  30          


Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu Asp 
        35                  40                  45              


Lys Tyr Lys Cys Glu Lys Cys Arg Leu Val Leu Cys Asn Pro Lys Gln 
    50                  55                  60                  


Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu 
65                  70                  75                  80  


Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Ile Lys 
                85                  90                  95      


Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala Leu 
            100                 105                 110         


Gln Val Tyr Cys Arg Asn Glu Gly Arg Gly Cys Ala Glu Gln Leu Thr 
        115                 120                 125             


Leu Gly His Leu Leu Val His Leu Lys Asn Glu Cys Gln Phe Glu Glu 
    130                 135                 140                 


Leu Pro Cys Leu Arg Ala Asp Cys Lys Glu Lys Val Leu Arg Lys Asp 
145                 150                 155                 160 


Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr Cys 
                165                 170                 175     


Ser His Cys Lys Ser Gln Val Pro Met Ile Lys Leu Gln Lys His Glu 
            180                 185                 190         


Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys Ser 
        195                 200                 205             


Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu Cys 
    210                 215                 220                 


Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val Phe 
225                 230                 235                 240 


Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala Val 
                245                 250                 255     


Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys Lys 
            260                 265                 270         


Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile Gln 
        275                 280                 285             


Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg Gln 
    290                 295                 300                 


Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln Arg 
305                 310                 315                 320 


Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu Ile 
                325                 330                 335     


Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser Ser 
            340                 345                 350         


Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp Lys 
        355                 360                 365             


Ser Ala Gly Gln Ala Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln Leu 
    370                 375                 380                 


Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala Asp 
385                 390                 395                 400 


Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly Val 
                405                 410                 415     


Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala Val 
            420                 425                 430         


Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr 
        435                 440                 445             


Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met 
    450                 455                 460                 


Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu 
465                 470                 475                 480 


Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu Met 
                485                 490                 495     


Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe Lys 
            500                 505                 510         


Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met Asn 
        515                 520                 525             


Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu Asn 
    530                 535                 540                 


Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val Asp 
545                 550                 555                 560 


Thr Ser Asp Leu Pro Asp Pro 
                565         


<210>  28
<211>  6978
<212>  DNA
<213>  Mus musculus

<400>  28
agcgcgcgag aggaagtgcc agcgcgaggg tgcgtgaggc ggcgcggccg gcggccgccg       60

cgtgcgcgag ccgggttgca gcccagcagg gactttccag ccggcggcgg cggcggcggc      120

cgccggccct tccccgcccc ccgacatggg gctgcccggg gagctggacg ctgcagaagg      180

cggcggagga tgcgcgcggc gcccctgagc cggccgaacg ggcgggcctc gggaatttca      240

gtttcctaag atggagtcaa gcaaaaagat ggatgctgct ggcacactgc agcctaaccc      300

acccctaaag ctgcagcctg atcgcggcgc agggtccgtg ctcgtgccgg agcaaggagg      360

ctacaaggag aagtttgtga agacggtgga agacaagtac aagtgcgaga agtgccgcct      420

ggtgctgtgc aacccgaagc agacggagtg tggccaccgg ttctgcgaga gctgcatggc      480

cgccctgctg agctcctcca gtccaaaatg cacagcgtgc caagaaagca tcatcaaaga      540

caaggtgttt aaggataatt gctgcaagag agagattctg gcccttcagg tctactgtcg      600

gaatgaaggc agaggttgtg cggagcagct gactctggga catctgctgg tgcacctaaa      660

aaatgaatgt cagtttgagg aacttccctg tctgcgtgcc gactgcaaag aaaaagtact      720

gagaaaagac ttgcgggatc acgtggaaaa ggcctgtaaa taccgcgagg ccacgtgcag      780

tcactgcaag agccaagtgc ccatgatcaa actgcagaaa catgaagaca cagattgtcc      840

ctgtgtggtg gtatcctgcc ctcacaagtg cagcgttcag actcttctaa ggagtgaggg      900

tacaaaccag cagatcaagg cccatgaggc cagctccgcg gtacagcacg tgaacctgct      960

gaaggagtgg agcaactccc tggagaagaa ggtttccctg ctgcagaatg aaagtgttga     1020

gaaaaacaag agcatccaaa gcctgcacaa ccagatctgc agctttgaga tcgagattga     1080

gaggcagaag gagatgctcc gaaacaacga gtccaagatc cttcacctgc agcgggtaat     1140

cgacagccaa gcagagaaac tgaaagaact ggacaaggag atccgtccct tccggcagaa     1200

ctgggaggaa gcggacagca tgaagagcag tgtggagtcc ctccagaacc gagtgactga     1260

gctggagagc gtagacaaaa gtgcggggca ggcggctcgc aacacaggct tgctggagtc     1320

ccagctgagc cggcatgacc agatgttgag tgttcatgac atccgcttgg ccgacatgga     1380

cctgcggttc caggtcctcg agaccgccag ctacaacggg gtgctgatct ggaagatccg     1440

tgactacaag cgccggaagc aggaggccgt catggggaag accctgtctc tctacagcca     1500

gcctttctac acaggttatt ttggctataa gatgtgtgcc agggtctacc tgaatgggga     1560

cggaatgggg aaagggacac acttgtcgct gttttttgtc attatgcgtg gagaatatga     1620

tgctctgttg ccatggccgt tcaagcagaa agtgacactt atgctgatgg atcaggggtc     1680

ctctcgccgt catctgggag atgcgttcaa gcctgacccc aacagcagca gcttcaagaa     1740

acccaccgga gagatgaata tcgcctctgg ctgcccagtc tttgtcgccc aaactgttct     1800

agagaacggg acgtatatta aagatgatac aatctttatt aaggtcatag tggatacctc     1860

ggatctgcct gacccctgac aagaaagcag ggcggtggat tcagcagaag gtaactcctc     1920

tgggggggtg agctagtgtc ttcacggagg tcctcgccct cagaaaggac cttgtgggac     1980

agaggaagca gccggaggag gagaaggagg tcgagtggct ggcaggagag ccacatgtga     2040

aaacagaccc caacggattt tctaatagac tagccacacc cactctgaag gattatttat     2100

ccatcaacaa gataaatact gctgtcagag aaggttttca ttttcatttt aaaagatcta     2160

gttaattaag gtgggaacat atatgctaaa aagaaacatg atttttcttc cttaacttaa     2220

acaccaaaaa gagaacacat gtgggggtag ctggatgtgt cagcatgtta acctacgagg     2280

agaacttatg aaatcataac acaatcccca tatactcatc ctaaaattca agagtgcaat     2340

cttgtttcaa atatagtata ttgtctattt ttaaggcctc atctggtctc tgttttaata     2400

atttgtttgt cagaagaccc tgagtaggca gaaggtctct aaattcagaa gtcattttta     2460

atttaaagtt ctacaaataa ttgttactgc aaacattttg ttttaaaacg ttgatagact     2520

gatatttctt ggaagaaaat gtaaaatatc aaacactggt tatcacttgt gataggaaag     2580

agaatattga acctgctgtt atttctcgtt agaaatgtaa cccttcgata tctgtcgtag     2640

ttagtgacac tacttcacaa tgactatgag agggacaatg ctcatggatg ctgtgcatca     2700

tttcagactt aacaattgtt ttcaccctaa aatagggcat tagttgaact ttggagttct     2760

aaacaaaatc ctataggttt ttacaattct gccccatgtt tagacaagct ctgttgctga     2820

cagcaccagc cttggtctcc agtgtcggtg tccggggata ggcaggtgac ccgtgccgca     2880

ggcaggaggc cccagcgagc atcccatcct gtcatactgc tgcatccggc tagcgcgctc     2940

cgaaagcaac atccgtgctc agagatggtg gcatacggta cttgtgcctt agatgtgaca     3000

tgctgcttct tgtccctggg tttgcgttca ccatggttct agaaagtgtc agtttaacca     3060

gatctctctc caccaccaga actttgtctc tgccagggcc ctcaggcaac tctgaacctg     3120

cctggggatg ccaggcctcc attggcagct cttgaagcct ctgctgctaa atattcacag     3180

attccaaccg taggccccta agagcagctc agtcccactc caagggaggg aggtgtgagc     3240

agaagccaca cccttccagg tctctgcaag ggccctgaaa tccccacagc atgaaggaga     3300

agtgccctag tcccaagcgt tcccgagacc actggtctgg ggcctgcccg ggctggcagc     3360

agcaaccctg gcctccctgt gaggagggca gccagctgat gcccagcctg tgagtgcaga     3420

ggcccgccct ctcagctcac tgttcccact gtgatgagaa gcctggagcc ctgccccggt     3480

gccccttttg ctatgcacca cacttcacgg tgctctacac tgatgggtgc tacacgcgac     3540

aggtgcttct taggcaaaac caatgtgtgc aaaccaccac atctgtgcca cttgcccaaa     3600

aggcgcgccc acaattggcc agctgggcct gcgcttcaga ctgcctgcct ctgggctctc     3660

cccatggtcg cacggggaca gctgggttgg tgcccggtag cccaccttgt ctctggtgct     3720

gccatctgtc ctgggtgtgc cttcgcccca gtgcctgctg gaagtgccct cctctcgcac     3780

acctgtcccc gtgcttccat gagcgacctc ttggtttcga gcactcaccc tgcccttcca     3840

tggctgaagc gtttggtttg tcctctgctc cccgcttctc tccattatgc tgggattgct     3900

ttggggtaag tcagcaacct tggttctgcc cacaaggaaa gaccgcagag ctcaagttct     3960

ttcaaaggtg ccctcctctt cctctaggcc tgtcaccagg gttcctcccc caaagacctg     4020

gagttggggg gaacacccag cagtccttgg ctggcttcag gaagcttttc tgtggccaga     4080

tgtcagcaac ggggccatcc ctgtagctcc ccccttcaga gaaatcagtg cagtatcaac     4140

aggtgtaggc cagcagcatc gtgtctgaca aaaagcatgt ctgtccttag tttcagaccc     4200

ttgtatgagg gtgaccctga catgtcctcg ggcccgtcct cccttttagt gagacttggt     4260

caaggctcct tcctatgcga ggtggccctc ctggcttccc ccgtgcctgt agggtgtgtg     4320

taaagtaagt gactgctccc ctgggatgag ggccctgaac aatgtcacag cttcctgtag     4380

tgtgttgtgt ctattgcatt tctcggtaac tgtagaatag tgggcaagct tgcccctctg     4440

tgccctgtct cagtgtgtga agggcatctc ctgggaggtg tggagcaggc tgcgtcctgc     4500

ctgggtgtgc cttgctctgc tccatctcag cattccttgg tgctcaccac ccgggggtgt     4560

ggggcattgt tgggctgtgg tctcagcata gctgtggcta ccagtcctag cagctagccc     4620

tcaccatatc acagggtcct ggccatgaga agtatggggt gtcatgcggc gtgtgtacct     4680

ggctgtgcaa aagtgtcaag tgctcatctt ttaagaggcc ggtagttgca tggcctctgt     4740

ggggaaattg gatacaactc ctgcttgccg gggtggtgtt tgtacctgct cacagctgac     4800

cctgggaaga tggcagccac taactagcag tgtgtcctga ggcccagcct gcagtttttt     4860

gtgaatagct gaaagcttgt gtcagtaaca acccagggcc ttccaccttc gttggtcagg     4920

gagaagaagg tagcctgggg tgccctggcc gagcctcctt cacctcttgg ggatagacag     4980

agccagcgga ggccacacat gtaggccgcg tgtgagaggg atgggtgaga ctgtgaatga     5040

gtgtaacaca ctgagtgtga gctgggctca cacaggagag cagagcccat gcccagcatt     5100

ccaggaagca aagggctgtg agagggtccg catcctcttc ctttctaaag tagcctgtgc     5160

acagatggcg ccatgtccct aagacagcac aacagtcaga cagcacagcc atgagctgag     5220

ggaggtgtct gcttacagcc accgtccgcc tcctttcttt ctctgctctt ttcccgttta     5280

ttccaaggac tgggcagcct ccagcagggc cttcagaccc acccccacca gatccctttg     5340

aaatatgtgg tcagcctcat gagaacctag ctgtcagccc cctgtggata gctagccacc     5400

ttcccatccc tccttagtca gcccctgtcc caccaggagt tgggacctca tgcctgctat     5460

cttgggcctg acattaactg aacagtatac atagcagtca cccacggcag acctggcaac     5520

cagtggacag catccagcaa agatgaggat gtctgggcac gccaagtaac ggggtcctag     5580

gtggaccact cctgccggcc caagaggaga ccagggggag tgccagggtc agcagcatgg     5640

cccttgctgc ccctccccct gtgcactgcc atgcattgca gggacttttg tacctggcca     5700

aggcatttcc cccgacaggt gacagggttg gtcagtcctc actctcccat acatccctct     5760

gcttgggagc atcagtgaat agagaagggc ttgatggtgc ttaggggact atttttttac     5820

tttcaatcca gaagagctag tgtgggcttc atgccatcat gtcctgagtg tgtgtgacaa     5880

atgagggtct gactctcgaa tctcctcaga ccaagactct atcttctatt tgcacaccca     5940

tagcagctgt tttctccaag ctcaaatgtg cccacggggg tctgatcagg tgaggtgatc     6000

attggcaagt gacccagccg ttgccagctc tcccaccccg gctgctgctg ctagccacga     6060

ggactgtggc gtccaggagc ccatccccca acctggacct atcctagcct gttgtctgct     6120

tgggcaccat tactaggtag gcaggcaagg cagtgaccca caccaaagcc agccctacag     6180

ctgagcatgc cccagcaccc aagcagcggg tatgatccaa ttccctaacc gcaccacgtc     6240

tggagtctgt cctgtgagct cactgtggaa aggaggttac aagcccaggt cactgtgcca     6300

ctccatagtc agtggcgacc agcgtgcacc cctaatcccc ttagtcactt aagaaaacct     6360

tcaaaggcaa ataaatgacc taattggaaa acacaaaagc cggccttcct cccaaggatt     6420

ccctaagaat ctgtgggcgc tctgactgag taggttgggg tcagtgcaga cagctgcaga     6480

ctgttctaaa gttccgttct tatctctgat ggcacacctc tcgtgttcag ttctattacc     6540

caaaaaacaa agaccaaaga aggccaatct ctcatttgac cgtattttta atctgcctgt     6600

tttgacacat gccgtctgta gtaaccgctc gctgtgaggc cccatcttga cagtccaagt     6660

gatcgtgacc agtgattagc gtcccgtgtt ctaatgctct tctaagaaac tgagacagtg     6720

tgaattattg ctcagcaata atcatgtcac caggagttag cagcacgcct catctcctga     6780

tagcattatg atgtttcgtg ttttgtttac cgtgtgttac atgtaaggtt tcatttggta     6840

tttatttgtg ttttgaggtc ttgcgatgtt tctgttctgc tgctaataat aaagtttgta     6900

agactgtaga atgcagaatt ttgtaatgct caagtgtcta ttagaggaaa ataaagctga     6960

ttcaagagtc cggcaaaa                                                   6978


<210>  29
<211>  542
<212>  PRT
<213>  Mus musculus

<400>  29

Met Glu Ser Ser Lys Lys Met Asp Ala Ala Gly Thr Leu Gln Pro Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu Gln Pro Asp Arg Gly Ala Gly Ser Val Leu Val 
            20                  25                  30          


Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu Asp 
        35                  40                  45              


Lys Tyr Lys Cys Glu Lys Cys Arg Leu Val Leu Cys Asn Pro Lys Gln 
    50                  55                  60                  


Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu 
65                  70                  75                  80  


Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Ile Lys 
                85                  90                  95      


Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala Leu 
            100                 105                 110         


Gln Val Tyr Cys Arg Asn Glu Gly Arg Gly Cys Ala Glu Gln Leu Thr 
        115                 120                 125             


Leu Gly His Leu Leu Val His Leu Lys Asn Glu Cys Gln Phe Glu Glu 
    130                 135                 140                 


Leu Pro Cys Leu Arg Ala Asp Cys Lys Glu Lys Val Leu Arg Lys Asp 
145                 150                 155                 160 


Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr Cys 
                165                 170                 175     


Ser His Cys Lys Ser Gln Val Pro Met Ile Lys Leu Gln Lys His Glu 
            180                 185                 190         


Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys Ser 
        195                 200                 205             


Val Gln Thr Leu Leu Arg Ser Glu Gly Thr Asn Gln Gln Ile Lys Ala 
    210                 215                 220                 


His Glu Ala Ser Ser Ala Val Gln His Val Asn Leu Leu Lys Glu Trp 
225                 230                 235                 240 


Ser Asn Ser Leu Glu Lys Lys Val Ser Leu Leu Gln Asn Glu Ser Val 
                245                 250                 255     


Glu Lys Asn Lys Ser Ile Gln Ser Leu His Asn Gln Ile Cys Ser Phe 
            260                 265                 270         


Glu Ile Glu Ile Glu Arg Gln Lys Glu Met Leu Arg Asn Asn Glu Ser 
        275                 280                 285             


Lys Ile Leu His Leu Gln Arg Val Ile Asp Ser Gln Ala Glu Lys Leu 
    290                 295                 300                 


Lys Glu Leu Asp Lys Glu Ile Arg Pro Phe Arg Gln Asn Trp Glu Glu 
305                 310                 315                 320 


Ala Asp Ser Met Lys Ser Ser Val Glu Ser Leu Gln Asn Arg Val Thr 
                325                 330                 335     


Glu Leu Glu Ser Val Asp Lys Ser Ala Gly Gln Ala Ala Arg Asn Thr 
            340                 345                 350         


Gly Leu Leu Glu Ser Gln Leu Ser Arg His Asp Gln Met Leu Ser Val 
        355                 360                 365             


His Asp Ile Arg Leu Ala Asp Met Asp Leu Arg Phe Gln Val Leu Glu 
    370                 375                 380                 


Thr Ala Ser Tyr Asn Gly Val Leu Ile Trp Lys Ile Arg Asp Tyr Lys 
385                 390                 395                 400 


Arg Arg Lys Gln Glu Ala Val Met Gly Lys Thr Leu Ser Leu Tyr Ser 
                405                 410                 415     


Gln Pro Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val 
            420                 425                 430         


Tyr Leu Asn Gly Asp Gly Met Gly Lys Gly Thr His Leu Ser Leu Phe 
        435                 440                 445             


Phe Val Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe 
    450                 455                 460                 


Lys Gln Lys Val Thr Leu Met Leu Met Asp Gln Gly Ser Ser Arg Arg 
465                 470                 475                 480 


His Leu Gly Asp Ala Phe Lys Pro Asp Pro Asn Ser Ser Ser Phe Lys 
                485                 490                 495     


Lys Pro Thr Gly Glu Met Asn Ile Ala Ser Gly Cys Pro Val Phe Val 
            500                 505                 510         


Ala Gln Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile 
        515                 520                 525             


Phe Ile Lys Val Ile Val Asp Thr Ser Asp Leu Pro Asp Pro 
    530                 535                 540         


<210>  30
<211>  3571
<212>  DNA
<213>  Homo sapiens

<400>  30
aagccccgcc cgttcctccg aaattgggtc gcagtcccac cctctctcct agtacttcct       60

gttctcggct aaccctggcg ctgggccggg ggctggagag tgaccgtggt ctgagtgacc      120

tggggcggct gcgtgggccg gggtgggcct caaagccggg caccagacgg gaggggcggc      180

gctcgggccg cgcgctgccc gcgccgggtc ctggcgggcg gcgaggctgg ggctgactcc      240

tgcctcagga tgccggggga ggaagaggag cgggccttcc tggtggcccg cgaggagctg      300

gcgagcgccc tgaggaggga ttccgggcag gcgttttccc tggagcagct ccggccgcta      360

ctagccagct ctctgccgct agccgcccgc tacctgcagc tggacgccgc acgccttgtc      420

cgctgcaacg ctcatgggga gccccgaaac tacctcaaca ccctgtccac ggctctgaac      480

atcctggaga aatacggccg caaccttctc agccctcagc ggcctcggta ctggcgtggt      540

gtcaagttta ataaccctgt ctttcgcagc acggtggatg ctgtgcaggg gggccgagat      600

gtgctgcgat tatatggcta cacagaggag caaccagatg ggttgagctt ccccgaaggg      660

caggaggagc cagatgagca ccaggttgct acagtcacac tggaagtact gctgcttcgg      720

acagagctca gcctgctatt gcagaatact catccaagac agcaggcact ggagcagctg      780

ttggaagaca aggttgaaga tgatatgctg cagctttcag aatttgaccc cctattgaga      840

gagattgctc ctggccccct caccacaccc tctgtcccag gctccactcc tggtccctgc      900

ttcctctgtg gttctgcccc aggcacactg cactgcccat cctgtaaaca ggccctgtgt      960

ccagcctgtg accacctgtt ccatggacac ccatcccgtg ctcatcacct ccgccagacc     1020

ctgcctgggg tcctgcaggg tacccacctg agccccagtt tacctgcctc agcccaacca     1080

cggccccagt cgacctccct gctggccctg ggagacagct ctctttcttc ccctaatcct     1140

gcaagtgctc atttgccctg gcactgtgct gcctgtgcca tgctaaatga gccttgggca     1200

gtgctctgtg tggcctgtga tcggccccga ggctgtaagg ggttggggtt gggaactgag     1260

ggtccccaag gaactggagg cctagaacct gatcttgcac ggggtcggtg ggcctgccag     1320

agctgtacct ttgagaatga ggcagctgct gtgctatgtt ccatatgtga gcgacctcgg     1380

ctggcccagc ctcccagctt ggtggtggat tcccgagatg ctggcatttg cctgcaaccc     1440

cttcagcagg gggatgcttt gctggcctct gcccagagtc aagtctggta ctgtattcac     1500

tgtaccttct gcaactcgag ccctggctgg gtgtgtgtta tgtgcaaccg gactagtagc     1560

cccattccag cacaacatgc cccccggccc tatgccagct ctttggaaaa gggacccccc     1620

aagcctgggc ccccacgacg ccttagtgcc cccctgccca gttcctgtgg agatcctgag     1680

aagcagcgcc aagacaagat gcgggaagaa ggcctccagc tagtgagcat gatccgggaa     1740

ggggaagccg caggtgcctg tccagaggag atcttctcgg ctctgcagta ctcgggcact     1800

gaggtgcctc tgcagtggtt gcgctcagaa ctgccctacg tcctggagat ggtggctgag     1860

ctggctggac agcaggaccc tgggctgggt gccttttcct gtcaggaggc ccggagagcc     1920

tggctggatc gtcatggcaa ccttgatgaa gctgtggagg agtgtgtgag gaccaggcga     1980

aggaaggtgc aggagctcca gtctctaggc tttgggcctg aggaggggtc tctccaggca     2040

ttgttccagc acggaggtga tgtgtcacgg gccctgactg agctacagcg ccaacgccta     2100

gagcccttcc gccagcgcct ctgggacagt ggccctgagc ccaccccttc ctgggatggg     2160

ccagacaagc agagcctggt caggcggctt ttggcagtct acgcactccc cagctggggc     2220

cgggcagagc tggcactgtc actgctgcag gagacaccca ggaactatga gttgggggat     2280

gtggtagaag ctgtgaggca cagccaggac cgggccttcc tgcgccgctt gcttgcccag     2340

gagtgtgccg tgtgtggctg ggccctgccc cacaaccgga tgcaggccct gacttcctgt     2400

gagtgcacca tctgtcctga ctgcttccgc cagcacttca ccatcgcctt gaaggagaag     2460

cacatcacag acatggtgtg ccctgcctgt ggccgccccg acctcaccga tgacacacag     2520

ttgctcagct acttctctac ccttgacatc cagcttcgcg agagcctaga gccagatgcc     2580

tatgcgttgt tccataagaa gctgaccgag ggtgtgctga tgcgggaccc caagttcttg     2640

tggtgtgccc agtgctcctt tggcttcata tatgagcgtg agcagctgga ggcaacttgt     2700

ccccagtgtc accagacctt ctgtgtgcgc tgcaagcgcc agtgggagga gcagcaccga     2760

ggtcggagct gtgaggactt ccagaactgg aaacgcatga acgacccaga ataccaggcc     2820

cagggcctag caatgtatct tcaggaaaac ggcattgact gccccaaatg caagttctcg     2880

tacgccctgg cccgaggagg ctgcatgcac tttcactgta cccagtgccg ccaccagttc     2940

tgcagcggct gctacaatgc cttttacgcc aagaataaat gtccagagcc taactgcagg     3000

gtgaaaaagt ccctgcacgg ccaccaccct cgagactgcc tcttctacct gcgggactgg     3060

actgctctcc ggcttcagaa gctgctacag gacaataacg tcatgtttaa tacagagcct     3120

ccagctgggg cccgggcagt ccctggaggc ggctgccgag tgatagagca gaaggaggtt     3180

cccaatgggc tcagggacga agcttgtggc aaggaaactc cagctggcta tgccggcctg     3240

tgccaggcac actacaaaga gtatcttgtg agcctcatca atgcccactc gctggaccca     3300

gccaccttgt atgaggtgga agagctggag acggccactg agcgctacct gcacgtacgc     3360

ccccagcctt tggctggaga ggatccccct gcttaccagg cccgcttgtt acagaagctg     3420

acagaagagg tacccttggg acagagtatc ccccgcaggc ggaagtagct gagggcaagg     3480

gtcccgatga gggtcccatg gcctgctccc tcaggaacag ctccagcacc aataaagagg     3540

catcttacca cccaggaaaa aaaaaaaaaa a                                    3571


<210>  31
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Gly Glu Glu Glu Glu Arg Ala Phe Leu Val Ala Arg Glu Glu 
1               5                   10                  15      


Leu Ala Ser Ala Leu Arg Arg Asp Ser Gly Gln Ala Phe Ser Leu Glu 
            20                  25                  30          


Gln Leu Arg Pro Leu Leu Ala Ser Ser Leu Pro Leu Ala Ala Arg Tyr 
        35                  40                  45              


Leu Gln Leu Asp Ala Ala Arg Leu Val Arg Cys Asn Ala His Gly Glu 
    50                  55                  60                  


Pro Arg Asn Tyr Leu Asn Thr Leu Ser Thr Ala Leu Asn Ile Leu Glu 
65                  70                  75                  80  


Lys Tyr Gly Arg Asn Leu Leu Ser Pro Gln Arg Pro Arg Tyr Trp Arg 
                85                  90                  95      


Gly Val Lys Phe Asn Asn Pro Val Phe Arg Ser Thr Val Asp Ala Val 
            100                 105                 110         


Gln Gly Gly Arg Asp Val Leu Arg Leu Tyr Gly Tyr Thr Glu Glu Gln 
        115                 120                 125             


Pro Asp Gly Leu Ser Phe Pro Glu Gly Gln Glu Glu Pro Asp Glu His 
    130                 135                 140                 


Gln Val Ala Thr Val Thr Leu Glu Val Leu Leu Leu Arg Thr Glu Leu 
145                 150                 155                 160 


Ser Leu Leu Leu Gln Asn Thr His Pro Arg Gln Gln Ala Leu Glu Gln 
                165                 170                 175     


Leu Leu Glu Asp Lys Val Glu Asp Asp Met Leu Gln Leu Ser Glu Phe 
            180                 185                 190         


Asp Pro Leu Leu Arg Glu Ile Ala Pro Gly Pro Leu Thr Thr Pro Ser 
        195                 200                 205             


Val Pro Gly Ser Thr Pro Gly Pro Cys Phe Leu Cys Gly Ser Ala Pro 
    210                 215                 220                 


Gly Thr Leu His Cys Pro Ser Cys Lys Gln Ala Leu Cys Pro Ala Cys 
225                 230                 235                 240 


Asp His Leu Phe His Gly His Pro Ser Arg Ala His His Leu Arg Gln 
                245                 250                 255     


Thr Leu Pro Gly Val Leu Gln Gly Thr His Leu Ser Pro Ser Leu Pro 
            260                 265                 270         


Ala Ser Ala Gln Pro Arg Pro Gln Ser Thr Ser Leu Leu Ala Leu Gly 
        275                 280                 285             


Asp Ser Ser Leu Ser Ser Pro Asn Pro Ala Ser Ala His Leu Pro Trp 
    290                 295                 300                 


His Cys Ala Ala Cys Ala Met Leu Asn Glu Pro Trp Ala Val Leu Cys 
305                 310                 315                 320 


Val Ala Cys Asp Arg Pro Arg Gly Cys Lys Gly Leu Gly Leu Gly Thr 
                325                 330                 335     


Glu Gly Pro Gln Gly Thr Gly Gly Leu Glu Pro Asp Leu Ala Arg Gly 
            340                 345                 350         


Arg Trp Ala Cys Gln Ser Cys Thr Phe Glu Asn Glu Ala Ala Ala Val 
        355                 360                 365             


Leu Cys Ser Ile Cys Glu Arg Pro Arg Leu Ala Gln Pro Pro Ser Leu 
    370                 375                 380                 


Val Val Asp Ser Arg Asp Ala Gly Ile Cys Leu Gln Pro Leu Gln Gln 
385                 390                 395                 400 


Gly Asp Ala Leu Leu Ala Ser Ala Gln Ser Gln Val Trp Tyr Cys Ile 
                405                 410                 415     


His Cys Thr Phe Cys Asn Ser Ser Pro Gly Trp Val Cys Val Met Cys 
            420                 425                 430         


Asn Arg Thr Ser Ser Pro Ile Pro Ala Gln His Ala Pro Arg Pro Tyr 
        435                 440                 445             


Ala Ser Ser Leu Glu Lys Gly Pro Pro Lys Pro Gly Pro Pro Arg Arg 
    450                 455                 460                 


Leu Ser Ala Pro Leu Pro Ser Ser Cys Gly Asp Pro Glu Lys Gln Arg 
465                 470                 475                 480 


Gln Asp Lys Met Arg Glu Glu Gly Leu Gln Leu Val Ser Met Ile Arg 
                485                 490                 495     


Glu Gly Glu Ala Ala Gly Ala Cys Pro Glu Glu Ile Phe Ser Ala Leu 
            500                 505                 510         


Gln Tyr Ser Gly Thr Glu Val Pro Leu Gln Trp Leu Arg Ser Glu Leu 
        515                 520                 525             


Pro Tyr Val Leu Glu Met Val Ala Glu Leu Ala Gly Gln Gln Asp Pro 
    530                 535                 540                 


Gly Leu Gly Ala Phe Ser Cys Gln Glu Ala Arg Arg Ala Trp Leu Asp 
545                 550                 555                 560 


Arg His Gly Asn Leu Asp Glu Ala Val Glu Glu Cys Val Arg Thr Arg 
                565                 570                 575     


Arg Arg Lys Val Gln Glu Leu Gln Ser Leu Gly Phe Gly Pro Glu Glu 
            580                 585                 590         


Gly Ser Leu Gln Ala Leu Phe Gln His Gly Gly Asp Val Ser Arg Ala 
        595                 600                 605             


Leu Thr Glu Leu Gln Arg Gln Arg Leu Glu Pro Phe Arg Gln Arg Leu 
    610                 615                 620                 


Trp Asp Ser Gly Pro Glu Pro Thr Pro Ser Trp Asp Gly Pro Asp Lys 
625                 630                 635                 640 


Gln Ser Leu Val Arg Arg Leu Leu Ala Val Tyr Ala Leu Pro Ser Trp 
                645                 650                 655     


Gly Arg Ala Glu Leu Ala Leu Ser Leu Leu Gln Glu Thr Pro Arg Asn 
            660                 665                 670         


Tyr Glu Leu Gly Asp Val Val Glu Ala Val Arg His Ser Gln Asp Arg 
        675                 680                 685             


Ala Phe Leu Arg Arg Leu Leu Ala Gln Glu Cys Ala Val Cys Gly Trp 
    690                 695                 700                 


Ala Leu Pro His Asn Arg Met Gln Ala Leu Thr Ser Cys Glu Cys Thr 
705                 710                 715                 720 


Ile Cys Pro Asp Cys Phe Arg Gln His Phe Thr Ile Ala Leu Lys Glu 
                725                 730                 735     


Lys His Ile Thr Asp Met Val Cys Pro Ala Cys Gly Arg Pro Asp Leu 
            740                 745                 750         


Thr Asp Asp Thr Gln Leu Leu Ser Tyr Phe Ser Thr Leu Asp Ile Gln 
        755                 760                 765             


Leu Arg Glu Ser Leu Glu Pro Asp Ala Tyr Ala Leu Phe His Lys Lys 
    770                 775                 780                 


Leu Thr Glu Gly Val Leu Met Arg Asp Pro Lys Phe Leu Trp Cys Ala 
785                 790                 795                 800 


Gln Cys Ser Phe Gly Phe Ile Tyr Glu Arg Glu Gln Leu Glu Ala Thr 
                805                 810                 815     


Cys Pro Gln Cys His Gln Thr Phe Cys Val Arg Cys Lys Arg Gln Trp 
            820                 825                 830         


Glu Glu Gln His Arg Gly Arg Ser Cys Glu Asp Phe Gln Asn Trp Lys 
        835                 840                 845             


Arg Met Asn Asp Pro Glu Tyr Gln Ala Gln Gly Leu Ala Met Tyr Leu 
    850                 855                 860                 


Gln Glu Asn Gly Ile Asp Cys Pro Lys Cys Lys Phe Ser Tyr Ala Leu 
865                 870                 875                 880 


Ala Arg Gly Gly Cys Met His Phe His Cys Thr Gln Cys Arg His Gln 
                885                 890                 895     


Phe Cys Ser Gly Cys Tyr Asn Ala Phe Tyr Ala Lys Asn Lys Cys Pro 
            900                 905                 910         


Glu Pro Asn Cys Arg Val Lys Lys Ser Leu His Gly His His Pro Arg 
        915                 920                 925             


Asp Cys Leu Phe Tyr Leu Arg Asp Trp Thr Ala Leu Arg Leu Gln Lys 
    930                 935                 940                 


Leu Leu Gln Asp Asn Asn Val Met Phe Asn Thr Glu Pro Pro Ala Gly 
945                 950                 955                 960 


Ala Arg Ala Val Pro Gly Gly Gly Cys Arg Val Ile Glu Gln Lys Glu 
                965                 970                 975     


Val Pro Asn Gly Leu Arg Asp Glu Ala Cys Gly Lys Glu Thr Pro Ala 
            980                 985                 990         


Gly Tyr Ala Gly Leu Cys Gln Ala  His Tyr Lys Glu Tyr  Leu Val Ser 
        995                 1000                 1005             


Leu Ile  Asn Ala His Ser Leu  Asp Pro Ala Thr Leu  Tyr Glu Val 
    1010                 1015                 1020             


Glu Glu  Leu Glu Thr Ala Thr  Glu Arg Tyr Leu His  Val Arg Pro 
    1025                 1030                 1035             


Gln Pro  Leu Ala Gly Glu Asp  Pro Pro Ala Tyr Gln  Ala Arg Leu 
    1040                 1045                 1050             


Leu Gln  Lys Leu Thr Glu Glu  Val Pro Leu Gly Gln  Ser Ile Pro 
    1055                 1060                 1065             


Arg Arg  Arg Lys 
    1070         


<210>  32
<211>  3227
<212>  DNA
<213>  Homo sapiens

<400>  32
atagctaggg ccaactggaa gtccagggtt gggccccgaa actacctcaa caccctgtcc       60

acggctctga acatcctgga gaaatacggc cgcaaccttc tcagccctca gcggcctcgg      120

tactggcgtg gtgtcaagtt taataaccct gtctttcgca gcacggtgga tgctgtgcag      180

gggggccgag atgtgctgcg attatatggc tacacagagg agcaaccaga tgggttgagc      240

ttccccgaag ggcaggagga gccagatgag caccaggttg ctacagtcac actggaagta      300

ctgctgcttc ggacagagct cagcctgcta ttgcaggtga gatgctcctc tagtcttgat      360

ggacttatgc accagggctg gggagcccag cctaactcaa aatactcatc caagacagca      420

ggcactggag cagctgttgg aagacaaggt tgaagatgat atgctgcagc tttcagaatt      480

tgacccccta ttgagagaga ttgctcctgg ccccctcacc acaccctctg tcccaggctc      540

cactcctggt ccctgcttcc tctgtggttc tgccccaggc acactgcact gcccatcctg      600

taaacaggcc ctgtgtccag cctgtgacca cctgttccat ggacacccat cccgtgctca      660

tcacctccgc cagaccctgc ctggggtcct gcagggtacc cacctgagcc ccagtttacc      720

tgcctcagcc caaccacggc cccagtcgac ctccctgctg gccctgggag acagctctct      780

ttcttcccct aatcctgcaa gtgctcattt gccctggcac tgtgctgcct gtgccatgct      840

aaatgagcct tgggcagtgc tctgtgtggc ctgtgatcgg ccccgaggct gtaaggggtt      900

ggggttggga actgagggtc cccaaggaac tggaggccta gaacctgatc ttgcacgggg      960

tcggtgggcc tgccagagct gtacctttga gaatgaggca gctgctgtgc tatgttccat     1020

atgtgagcga cctcggctgg cccagcctcc cagcttggtg gtggattccc gagatgctgg     1080

catttgcctg caaccccttc agcaggggga tgctttgctg gcctctgccc agagtcaagt     1140

ctggtactgt attcactgta ccttctgcaa ctcgagccct ggctgggtgt gtgttatgtg     1200

caaccggact agtagcccca ttccagcaca acatgccccc cggccctatg ccagctcttt     1260

ggaaaaggga ccccccaagc ctgggccccc acgacgcctt agtgcccccc tgcccagttc     1320

ctgtggagat cctgagaagc agcgccaaga caagatgcgg gaagaaggcc tccagctagt     1380

gagcatgatc cgggaagggg aagccgcagg tgcctgtcca gaggagatct tctcggctct     1440

gcagtactcg ggcactgagg tgcctctgca gtggttgcgc tcagaactgc cctacgtcct     1500

ggagatggtg gctgagctgg ctggacagca ggaccctggg ctgggtgcct tttcctgtca     1560

ggaggcccgg agagcctggc tggatcgtca tggcaacctt gatgaagctg tggaggagtg     1620

tgtgaggacc aggcgaagga aggtgcagga gctccagtct ctaggctttg ggcctgagga     1680

ggggtctctc caggcattgt tccagcacgg aggtgatgtg tcacgggccc tgactgagct     1740

acagcgccaa cgcctagagc ccttccgcca gcgcctctgg gacagtggcc ctgagcccac     1800

cccttcctgg gatgggccag acaagcagag cctggtcagg cggcttttgg cagtctacgc     1860

actccccagc tggggccggg cagagctggc actgtcactg ctgcaggaga cacccaggaa     1920

ctatgagttg ggggatgtgg tagaagctgt gaggcacagc caggaccggg ccttcctgcg     1980

ccgcttgctt gcccaggagt gtgccgtgtg tggctgggcc ctgccccaca accggatgca     2040

ggccctgact tcctgtgagt gcaccatctg tcctgactgc ttccgccagc acttcaccat     2100

cgccttgaag gagaagcaca tcacagacat ggtgtgccct gcctgtggcc gccccgacct     2160

caccgatgac acacagttgc tcagctactt ctctaccctt gacatccagc ttcgcgagag     2220

cctagagcca gatgcctatg cgttgttcca taagaagctg accgagggtg tgctgatgcg     2280

ggaccccaag ttcttgtggt gtgcccagtg ctcctttggc ttcatatatg agcgtgagca     2340

gctggaggca acttgtcccc agtgtcacca gaccttctgt gtgcgctgca agcgccagtg     2400

ggaggagcag caccgaggtc ggagctgtga ggacttccag aactggaaac gcatgaacga     2460

cccagaatac caggcccagg gcctagcaat gtatcttcag gaaaacggca ttgactgccc     2520

caaatgcaag ttctcgtacg ccctggcccg aggaggctgc atgcactttc actgtaccca     2580

gtgccgccac cagttctgca gcggctgcta caatgccttt tacgccaaga ataaatgtcc     2640

agagcctaac tgcagggtga aaaagtccct gcacggccac caccctcgag actgcctctt     2700

ctacctgcgg gactggactg ctctccggct tcagaagctg ctacaggaca ataacgtcat     2760

gtttaataca gagcctccag ctggggcccg ggcagtccct ggaggcggct gccgagtgat     2820

agagcagaag gaggttccca atgggctcag ggacgaagct tgtggcaagg aaactccagc     2880

tggctatgcc ggcctgtgcc aggcacacta caaagagtat cttgtgagcc tcatcaatgc     2940

ccactcgctg gacccagcca ccttgtatga ggtggaagag ctggagacgg ccactgagcg     3000

ctacctgcac gtacgccccc agcctttggc tggagaggat ccccctgctt accaggcccg     3060

cttgttacag aagctgacag aagaggtacc cttgggacag agtatccccc gcaggcggaa     3120

gtagctgagg gcaagggtcc cgatgagggt cccatggcct gctccctcag gaacagctcc     3180

agcaccaata aagaggcatc ttaccaccca ggaaaaaaaa aaaaaaa                   3227


<210>  33
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Leu Cys Thr Arg Ala Gly Glu Pro Ser Leu Thr Gln Asn Thr 
1               5                   10                  15      


His Pro Arg Gln Gln Ala Leu Glu Gln Leu Leu Glu Asp Lys Val Glu 
            20                  25                  30          


Asp Asp Met Leu Gln Leu Ser Glu Phe Asp Pro Leu Leu Arg Glu Ile 
        35                  40                  45              


Ala Pro Gly Pro Leu Thr Thr Pro Ser Val Pro Gly Ser Thr Pro Gly 
    50                  55                  60                  


Pro Cys Phe Leu Cys Gly Ser Ala Pro Gly Thr Leu His Cys Pro Ser 
65                  70                  75                  80  


Cys Lys Gln Ala Leu Cys Pro Ala Cys Asp His Leu Phe His Gly His 
                85                  90                  95      


Pro Ser Arg Ala His His Leu Arg Gln Thr Leu Pro Gly Val Leu Gln 
            100                 105                 110         


Gly Thr His Leu Ser Pro Ser Leu Pro Ala Ser Ala Gln Pro Arg Pro 
        115                 120                 125             


Gln Ser Thr Ser Leu Leu Ala Leu Gly Asp Ser Ser Leu Ser Ser Pro 
    130                 135                 140                 


Asn Pro Ala Ser Ala His Leu Pro Trp His Cys Ala Ala Cys Ala Met 
145                 150                 155                 160 


Leu Asn Glu Pro Trp Ala Val Leu Cys Val Ala Cys Asp Arg Pro Arg 
                165                 170                 175     


Gly Cys Lys Gly Leu Gly Leu Gly Thr Glu Gly Pro Gln Gly Thr Gly 
            180                 185                 190         


Gly Leu Glu Pro Asp Leu Ala Arg Gly Arg Trp Ala Cys Gln Ser Cys 
        195                 200                 205             


Thr Phe Glu Asn Glu Ala Ala Ala Val Leu Cys Ser Ile Cys Glu Arg 
    210                 215                 220                 


Pro Arg Leu Ala Gln Pro Pro Ser Leu Val Val Asp Ser Arg Asp Ala 
225                 230                 235                 240 


Gly Ile Cys Leu Gln Pro Leu Gln Gln Gly Asp Ala Leu Leu Ala Ser 
                245                 250                 255     


Ala Gln Ser Gln Val Trp Tyr Cys Ile His Cys Thr Phe Cys Asn Ser 
            260                 265                 270         


Ser Pro Gly Trp Val Cys Val Met Cys Asn Arg Thr Ser Ser Pro Ile 
        275                 280                 285             


Pro Ala Gln His Ala Pro Arg Pro Tyr Ala Ser Ser Leu Glu Lys Gly 
    290                 295                 300                 


Pro Pro Lys Pro Gly Pro Pro Arg Arg Leu Ser Ala Pro Leu Pro Ser 
305                 310                 315                 320 


Ser Cys Gly Asp Pro Glu Lys Gln Arg Gln Asp Lys Met Arg Glu Glu 
                325                 330                 335     


Gly Leu Gln Leu Val Ser Met Ile Arg Glu Gly Glu Ala Ala Gly Ala 
            340                 345                 350         


Cys Pro Glu Glu Ile Phe Ser Ala Leu Gln Tyr Ser Gly Thr Glu Val 
        355                 360                 365             


Pro Leu Gln Trp Leu Arg Ser Glu Leu Pro Tyr Val Leu Glu Met Val 
    370                 375                 380                 


Ala Glu Leu Ala Gly Gln Gln Asp Pro Gly Leu Gly Ala Phe Ser Cys 
385                 390                 395                 400 


Gln Glu Ala Arg Arg Ala Trp Leu Asp Arg His Gly Asn Leu Asp Glu 
                405                 410                 415     


Ala Val Glu Glu Cys Val Arg Thr Arg Arg Arg Lys Val Gln Glu Leu 
            420                 425                 430         


Gln Ser Leu Gly Phe Gly Pro Glu Glu Gly Ser Leu Gln Ala Leu Phe 
        435                 440                 445             


Gln His Gly Gly Asp Val Ser Arg Ala Leu Thr Glu Leu Gln Arg Gln 
    450                 455                 460                 


Arg Leu Glu Pro Phe Arg Gln Arg Leu Trp Asp Ser Gly Pro Glu Pro 
465                 470                 475                 480 


Thr Pro Ser Trp Asp Gly Pro Asp Lys Gln Ser Leu Val Arg Arg Leu 
                485                 490                 495     


Leu Ala Val Tyr Ala Leu Pro Ser Trp Gly Arg Ala Glu Leu Ala Leu 
            500                 505                 510         


Ser Leu Leu Gln Glu Thr Pro Arg Asn Tyr Glu Leu Gly Asp Val Val 
        515                 520                 525             


Glu Ala Val Arg His Ser Gln Asp Arg Ala Phe Leu Arg Arg Leu Leu 
    530                 535                 540                 


Ala Gln Glu Cys Ala Val Cys Gly Trp Ala Leu Pro His Asn Arg Met 
545                 550                 555                 560 


Gln Ala Leu Thr Ser Cys Glu Cys Thr Ile Cys Pro Asp Cys Phe Arg 
                565                 570                 575     


Gln His Phe Thr Ile Ala Leu Lys Glu Lys His Ile Thr Asp Met Val 
            580                 585                 590         


Cys Pro Ala Cys Gly Arg Pro Asp Leu Thr Asp Asp Thr Gln Leu Leu 
        595                 600                 605             


Ser Tyr Phe Ser Thr Leu Asp Ile Gln Leu Arg Glu Ser Leu Glu Pro 
    610                 615                 620                 


Asp Ala Tyr Ala Leu Phe His Lys Lys Leu Thr Glu Gly Val Leu Met 
625                 630                 635                 640 


Arg Asp Pro Lys Phe Leu Trp Cys Ala Gln Cys Ser Phe Gly Phe Ile 
                645                 650                 655     


Tyr Glu Arg Glu Gln Leu Glu Ala Thr Cys Pro Gln Cys His Gln Thr 
            660                 665                 670         


Phe Cys Val Arg Cys Lys Arg Gln Trp Glu Glu Gln His Arg Gly Arg 
        675                 680                 685             


Ser Cys Glu Asp Phe Gln Asn Trp Lys Arg Met Asn Asp Pro Glu Tyr 
    690                 695                 700                 


Gln Ala Gln Gly Leu Ala Met Tyr Leu Gln Glu Asn Gly Ile Asp Cys 
705                 710                 715                 720 


Pro Lys Cys Lys Phe Ser Tyr Ala Leu Ala Arg Gly Gly Cys Met His 
                725                 730                 735     


Phe His Cys Thr Gln Cys Arg His Gln Phe Cys Ser Gly Cys Tyr Asn 
            740                 745                 750         


Ala Phe Tyr Ala Lys Asn Lys Cys Pro Glu Pro Asn Cys Arg Val Lys 
        755                 760                 765             


Lys Ser Leu His Gly His His Pro Arg Asp Cys Leu Phe Tyr Leu Arg 
    770                 775                 780                 


Asp Trp Thr Ala Leu Arg Leu Gln Lys Leu Leu Gln Asp Asn Asn Val 
785                 790                 795                 800 


Met Phe Asn Thr Glu Pro Pro Ala Gly Ala Arg Ala Val Pro Gly Gly 
                805                 810                 815     


Gly Cys Arg Val Ile Glu Gln Lys Glu Val Pro Asn Gly Leu Arg Asp 
            820                 825                 830         


Glu Ala Cys Gly Lys Glu Thr Pro Ala Gly Tyr Ala Gly Leu Cys Gln 
        835                 840                 845             


Ala His Tyr Lys Glu Tyr Leu Val Ser Leu Ile Asn Ala His Ser Leu 
    850                 855                 860                 


Asp Pro Ala Thr Leu Tyr Glu Val Glu Glu Leu Glu Thr Ala Thr Glu 
865                 870                 875                 880 


Arg Tyr Leu His Val Arg Pro Gln Pro Leu Ala Gly Glu Asp Pro Pro 
                885                 890                 895     


Ala Tyr Gln Ala Arg Leu Leu Gln Lys Leu Thr Glu Glu Val Pro Leu 
            900                 905                 910         


Gly Gln Ser Ile Pro Arg Arg Arg Lys 
        915                 920     


<210>  34
<211>  3443
<212>  DNA
<213>  Mus musculus

<400>  34
gcggtggctt aagtgacccg ggctgctgtg gcgccgcgcg cacctgcgcc agcccctgga       60

gggcagagaa gctgagcctg tctccagtct caggatgccg ggagacgagg agcgaggctt      120

cctggcggcc cgcgaggagc tggcgagcgc cctgaggtgg gattctgcgc aggtttttcc      180

cctggagcag ctcatgccgc ttctggccac ctctctgcca ccagccgccc gctacctgca      240

gctggacgcc ggacgcttgg tccgctgcaa cgctcatggg gagcctcgaa actacctcaa      300

caccctatcc acggccctga acatcctgga aaaatatggt cgcaacctcc tcagcccgca      360

gcggccccgg tattggcgct cagtgaagtt taataacccc gtctttcgca gcacggtgga      420

tgctgtgcag ggtggccggg atgtactacg gttgtatggc tatactgagg agcgcccaga      480

tggattgagt ttccccgaag ggcaggagga accagatgaa taccaggttg ctgttgtcac      540

actagaagta ctgctgcttc gcaccgagct cagtttgctg ttgcagaata ctcatcccag      600

acagaatgca ctggaccagc tgctaagaga gagcgttgaa gatggtatgc tgcagctttc      660

agagtttcac ccccttctga gggagattgt tcctggcccc cgcccctctg cccaaggctc      720

cactcctggt ccctgtttcc tctgtggttc tgccccaggc acactgcact gtccagcctg      780

taaccaagtc tcgtgcccag cttgtgacat tttgttccat gggcatccgt cccgtgcaca      840

tcaccttcgc caagccctgc ctgggtccca ccagactgcc agcctgagct ctagtttacc      900

tgcctcgtcc caaccacggc ccccctcctc ctccttggcc ctgggagata gctctctttc      960

ttcccctgac cctgcaaatg cctgtctgcc ctggcattgt cttacctgtg ccacactaaa     1020

tgagccttgg gcagtgttct gtgcagtctg tagtcagccc aaaggctgca aggtgccggg     1080

aatagagggt tcccatggaa ccgggggcct agaacctgag cctgcacggg atcaatgggc     1140

ctgccagagc tgtacctttg agaatgaggc agcagctgtg ctatgcgcca tatgtgagcg     1200

acctcggctg gcccagcctc ccagcttggt ggtggattcc catgatgctg gtgtttgcca     1260

acagtccctt aagcaggagg atcctttgct caccgctgcc cagcctcagg tgtggtactg     1320

tgaccattgt accttctgca attcaggccc tgtctgggtg tgtgccatgt gcaaccgaac     1380

ccgagacccc atccctacac agcctgccct ccagtcctat cccagctctt tggaaaaggg     1440

acgcccaaag ccagggtcct cacaacacct tggttcctcc ctgcctgctt cctgtggaga     1500

cccagagaaa caacgccaag ataagatgcg gaaggaaggt ctccagctcg tgagcatgat     1560

ccaggaagga gaaactgcgg gtgccagtcc agaagaggtc ttctcagctc tccaatactc     1620

aggcacagag gtgcccctcc agtggttgcg ttcagagctg tcctacgtcc tggagatggt     1680

ggctgagctt gctggacaac aggatccaga gctgggggcc ttttcctgtc aggaagcccg     1740

gaaagcctgg cttgatcgcc atggcaacct ggatgaagct gtagaggagt gtgtgagggc     1800

caggaggagg aaggtgcacg agctgcagtc cctgggcttt gggcctaagg aagggtcact     1860

acaggcattg ttccagcatg ggggtgacgt ggctcgggcc ctgactgagt tacagcgcca     1920

gcgcctggag cccttccatc agcgcctatg ggacagagac cctgaaccca ctccctgctg     1980

ggatgggctg gacagacaga gcttggtcag acgccttctg gccgtctaca cactccccag     2040

ctggggccga gcagagctgg cgctggcgct gctgcaggag acacccagga actatgagtt     2100

gttggacgtg gtggaggctg tgaggcacag ccaggaccgg gcctttctgc gtcgactgct     2160

tgcccaggaa tgtgctgtgt gcgggtgggc ccttccccgc aaccggatgc aggccctgat     2220

ctcctgtgag tgcaccatat gtcccgaatg cttccgccaa cacttcacca ttgccctgaa     2280

ggagaagcac atcacagaca tggtgtgccc tgcctgtggc cgccctgacc tcactgatga     2340

cgctcagtta ctcagctact tctccaccct tgacatccag ctcagagaga gcctagaccc     2400

cgatgcatat gccctgtttc acaagaagct gaccgaggct gtgcttatgc gagaccccaa     2460

gttcttgtgg tgcgcccagt gttcctttgg cttcatctat gaacgcgaac agctggaggc     2520

gacgtgtccc cagtgtcacc agaccttctg tgtgcgctgc aagcgccagt gggaggagca     2580

gcacagagga cggagttgtg aggatttcca gaactggaaa cgcaccaatg acccagagta     2640

ccaggctcaa ggcttggcca tgtaccttca ggaaaacggc attgactgtc cgaaatgcaa     2700

gttctcgtac gcactggccc ggggaggctg catgcacttc cactgcacgc agtgtcgaca     2760

ccagttctgc agtggctgct acaacgcctt ttacgccaag aataaatgtc cagaccctaa     2820

ctgcaaggtg aaaaagtccc tgcatggcca ccaccctcga gactgcctct tctacctacg     2880

ggactggact gctgcccgcc tccagaaact gttgcaggac aataatgtca tgtttaatac     2940

agagcctcca gctgggacac gggcagtccc tggagggggc tgcagagtga tggagcagaa     3000

ggaggtccat agtgggttca gggatgaagc ttgcggcaag gaaactccac ctggctatgc     3060

cggcctatgt caggcacact acaaagagta tctcgtgagc ctcatcaatg cccattcact     3120

ggacccagct accttgtatg aagtggagga gctggagaca gccactattc gctacctaca     3180

tttagctcct cagcccgcgg atggagagga tctgcctgct taccaggccc ggctattaca     3240

gaagctgaga gaagaggtac ccttgggaca gagtattgcc cgcagaagaa agtagtagca     3300

gagagccggg tcctgatggg acttcctgac ccaggcctca gcagcagttc cagcaccaat     3360

aaagaggcat cttatggcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaa                                             3443


<210>  35
<211>  1066
<212>  PRT
<213>  Mus musculus

<400>  35

Met Pro Gly Asp Glu Glu Arg Gly Phe Leu Ala Ala Arg Glu Glu Leu 
1               5                   10                  15      


Ala Ser Ala Leu Arg Trp Asp Ser Ala Gln Val Phe Pro Leu Glu Gln 
            20                  25                  30          


Leu Met Pro Leu Leu Ala Thr Ser Leu Pro Pro Ala Ala Arg Tyr Leu 
        35                  40                  45              


Gln Leu Asp Ala Gly Arg Leu Val Arg Cys Asn Ala His Gly Glu Pro 
    50                  55                  60                  


Arg Asn Tyr Leu Asn Thr Leu Ser Thr Ala Leu Asn Ile Leu Glu Lys 
65                  70                  75                  80  


Tyr Gly Arg Asn Leu Leu Ser Pro Gln Arg Pro Arg Tyr Trp Arg Ser 
                85                  90                  95      


Val Lys Phe Asn Asn Pro Val Phe Arg Ser Thr Val Asp Ala Val Gln 
            100                 105                 110         


Gly Gly Arg Asp Val Leu Arg Leu Tyr Gly Tyr Thr Glu Glu Arg Pro 
        115                 120                 125             


Asp Gly Leu Ser Phe Pro Glu Gly Gln Glu Glu Pro Asp Glu Tyr Gln 
    130                 135                 140                 


Val Ala Val Val Thr Leu Glu Val Leu Leu Leu Arg Thr Glu Leu Ser 
145                 150                 155                 160 


Leu Leu Leu Gln Asn Thr His Pro Arg Gln Asn Ala Leu Asp Gln Leu 
                165                 170                 175     


Leu Arg Glu Ser Val Glu Asp Gly Met Leu Gln Leu Ser Glu Phe His 
            180                 185                 190         


Pro Leu Leu Arg Glu Ile Val Pro Gly Pro Arg Pro Ser Ala Gln Gly 
        195                 200                 205             


Ser Thr Pro Gly Pro Cys Phe Leu Cys Gly Ser Ala Pro Gly Thr Leu 
    210                 215                 220                 


His Cys Pro Ala Cys Asn Gln Val Ser Cys Pro Ala Cys Asp Ile Leu 
225                 230                 235                 240 


Phe His Gly His Pro Ser Arg Ala His His Leu Arg Gln Ala Leu Pro 
                245                 250                 255     


Gly Ser His Gln Thr Ala Ser Leu Ser Ser Ser Leu Pro Ala Ser Ser 
            260                 265                 270         


Gln Pro Arg Pro Pro Ser Ser Ser Leu Ala Leu Gly Asp Ser Ser Leu 
        275                 280                 285             


Ser Ser Pro Asp Pro Ala Asn Ala Cys Leu Pro Trp His Cys Leu Thr 
    290                 295                 300                 


Cys Ala Thr Leu Asn Glu Pro Trp Ala Val Phe Cys Ala Val Cys Ser 
305                 310                 315                 320 


Gln Pro Lys Gly Cys Lys Val Pro Gly Ile Glu Gly Ser His Gly Thr 
                325                 330                 335     


Gly Gly Leu Glu Pro Glu Pro Ala Arg Asp Gln Trp Ala Cys Gln Ser 
            340                 345                 350         


Cys Thr Phe Glu Asn Glu Ala Ala Ala Val Leu Cys Ala Ile Cys Glu 
        355                 360                 365             


Arg Pro Arg Leu Ala Gln Pro Pro Ser Leu Val Val Asp Ser His Asp 
    370                 375                 380                 


Ala Gly Val Cys Gln Gln Ser Leu Lys Gln Glu Asp Pro Leu Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Pro Gln Val Trp Tyr Cys Asp His Cys Thr Phe Cys Asn 
                405                 410                 415     


Ser Gly Pro Val Trp Val Cys Ala Met Cys Asn Arg Thr Arg Asp Pro 
            420                 425                 430         


Ile Pro Thr Gln Pro Ala Leu Gln Ser Tyr Pro Ser Ser Leu Glu Lys 
        435                 440                 445             


Gly Arg Pro Lys Pro Gly Ser Ser Gln His Leu Gly Ser Ser Leu Pro 
    450                 455                 460                 


Ala Ser Cys Gly Asp Pro Glu Lys Gln Arg Gln Asp Lys Met Arg Lys 
465                 470                 475                 480 


Glu Gly Leu Gln Leu Val Ser Met Ile Gln Glu Gly Glu Thr Ala Gly 
                485                 490                 495     


Ala Ser Pro Glu Glu Val Phe Ser Ala Leu Gln Tyr Ser Gly Thr Glu 
            500                 505                 510         


Val Pro Leu Gln Trp Leu Arg Ser Glu Leu Ser Tyr Val Leu Glu Met 
        515                 520                 525             


Val Ala Glu Leu Ala Gly Gln Gln Asp Pro Glu Leu Gly Ala Phe Ser 
    530                 535                 540                 


Cys Gln Glu Ala Arg Lys Ala Trp Leu Asp Arg His Gly Asn Leu Asp 
545                 550                 555                 560 


Glu Ala Val Glu Glu Cys Val Arg Ala Arg Arg Arg Lys Val His Glu 
                565                 570                 575     


Leu Gln Ser Leu Gly Phe Gly Pro Lys Glu Gly Ser Leu Gln Ala Leu 
            580                 585                 590         


Phe Gln His Gly Gly Asp Val Ala Arg Ala Leu Thr Glu Leu Gln Arg 
        595                 600                 605             


Gln Arg Leu Glu Pro Phe His Gln Arg Leu Trp Asp Arg Asp Pro Glu 
    610                 615                 620                 


Pro Thr Pro Cys Trp Asp Gly Leu Asp Arg Gln Ser Leu Val Arg Arg 
625                 630                 635                 640 


Leu Leu Ala Val Tyr Thr Leu Pro Ser Trp Gly Arg Ala Glu Leu Ala 
                645                 650                 655     


Leu Ala Leu Leu Gln Glu Thr Pro Arg Asn Tyr Glu Leu Leu Asp Val 
            660                 665                 670         


Val Glu Ala Val Arg His Ser Gln Asp Arg Ala Phe Leu Arg Arg Leu 
        675                 680                 685             


Leu Ala Gln Glu Cys Ala Val Cys Gly Trp Ala Leu Pro Arg Asn Arg 
    690                 695                 700                 


Met Gln Ala Leu Ile Ser Cys Glu Cys Thr Ile Cys Pro Glu Cys Phe 
705                 710                 715                 720 


Arg Gln His Phe Thr Ile Ala Leu Lys Glu Lys His Ile Thr Asp Met 
                725                 730                 735     


Val Cys Pro Ala Cys Gly Arg Pro Asp Leu Thr Asp Asp Ala Gln Leu 
            740                 745                 750         


Leu Ser Tyr Phe Ser Thr Leu Asp Ile Gln Leu Arg Glu Ser Leu Asp 
        755                 760                 765             


Pro Asp Ala Tyr Ala Leu Phe His Lys Lys Leu Thr Glu Ala Val Leu 
    770                 775                 780                 


Met Arg Asp Pro Lys Phe Leu Trp Cys Ala Gln Cys Ser Phe Gly Phe 
785                 790                 795                 800 


Ile Tyr Glu Arg Glu Gln Leu Glu Ala Thr Cys Pro Gln Cys His Gln 
                805                 810                 815     


Thr Phe Cys Val Arg Cys Lys Arg Gln Trp Glu Glu Gln His Arg Gly 
            820                 825                 830         


Arg Ser Cys Glu Asp Phe Gln Asn Trp Lys Arg Thr Asn Asp Pro Glu 
        835                 840                 845             


Tyr Gln Ala Gln Gly Leu Ala Met Tyr Leu Gln Glu Asn Gly Ile Asp 
    850                 855                 860                 


Cys Pro Lys Cys Lys Phe Ser Tyr Ala Leu Ala Arg Gly Gly Cys Met 
865                 870                 875                 880 


His Phe His Cys Thr Gln Cys Arg His Gln Phe Cys Ser Gly Cys Tyr 
                885                 890                 895     


Asn Ala Phe Tyr Ala Lys Asn Lys Cys Pro Asp Pro Asn Cys Lys Val 
            900                 905                 910         


Lys Lys Ser Leu His Gly His His Pro Arg Asp Cys Leu Phe Tyr Leu 
        915                 920                 925             


Arg Asp Trp Thr Ala Ala Arg Leu Gln Lys Leu Leu Gln Asp Asn Asn 
    930                 935                 940                 


Val Met Phe Asn Thr Glu Pro Pro Ala Gly Thr Arg Ala Val Pro Gly 
945                 950                 955                 960 


Gly Gly Cys Arg Val Met Glu Gln Lys Glu Val His Ser Gly Phe Arg 
                965                 970                 975     


Asp Glu Ala Cys Gly Lys Glu Thr Pro Pro Gly Tyr Ala Gly Leu Cys 
            980                 985                 990         


Gln Ala His Tyr Lys Glu Tyr Leu  Val Ser Leu Ile Asn  Ala His Ser 
        995                 1000                 1005             


Leu Asp  Pro Ala Thr Leu Tyr  Glu Val Glu Glu Leu  Glu Thr Ala 
    1010                 1015                 1020             


Thr Ile  Arg Tyr Leu His Leu  Ala Pro Gln Pro Ala  Asp Gly Glu 
    1025                 1030                 1035             


Asp Leu  Pro Ala Tyr Gln Ala  Arg Leu Leu Gln Lys  Leu Arg Glu 
    1040                 1045                 1050             


Glu Val  Pro Leu Gly Gln Ser  Ile Ala Arg Arg Arg  Lys 
    1055                 1060                 1065     


<210>  36
<211>  3818
<212>  DNA
<213>  Homo sapiens

<400>  36
ccccgcctgc ggcccagctc cttcccgcgg ctctgcgatg cggcccgcag ggtgacccgg       60

gcgggagtcc ggggacccgc gatcagcccc ggaggacggg gtggggtcgc cccaaacagg      120

agcgccggga ccgctgggac cccgcactcg gcgtccgccg ccgccgggta gccgggcagt      180

ggaggtcccg gatgaggcga caatttttcc ggccccccct cccagtcccg ccccacttcc      240

ggggccgcca ctttcacttt ctcttccgcc gaagccgctc cccttgcgaa gaactggggc      300

ctcccgggag gagagagggc tttgccttga aacccgggac gccaggggcg ctcccgcaag      360

tgggggtcct ccgggacttg gaacgccccg gctgggtggt gtccgggcgt cctttccccg      420

cttcttccca cctcggctgg tcccgtttcc tcctgcgccc agtgcggacc tgtctcggcg      480

cccgctgccc tctcaccgcc ccacgcagga tcccggcctg gtcaccgggc agtgtgatgc      540

ttcccgactg ccgcggggac agcgaggcac acacagggct tgggccgcgc cggaggccac      600

acggcctggc tgagttgctc ctggtctccc gcctctccca ggcgacccgg aggtagcatt      660

tcccaggagg cacggtcccc cccaggggga tgggcacagc cacgccagat ggacgagaag      720

accaagaaag gctgtgggtg agcgtggagg atgctcagat gcacaccgtc accatctggc      780

tcacagtgcg ccctgatatg acagtggcgt ctctcaagga catggttttt ctggactatg      840

gcttcccacc agtcttgcag cagtgggtga ttgggcagcg gctggcacga gaccaggaga      900

ccctgcactc ccatggggtg cggcagaatg gggacagtgc ctacctctat ctgctgtcag      960

cccgcaacac ctccctcaac cctcaggagc tgcagcggga gcggcagctg cggatgctgg     1020

aagatctggg cttcaaggac ctcacgctgc agccgcgggg ccctctggag ccaggccccc     1080

caaagcccgg ggtcccccag gaacccggac gggggcagcc agatgcagtg cctgagcccc     1140

caccggtggg ctggcagtgc cccgggtgca ccttcatcaa caagcccacg cggcctggct     1200

gtgagatgtg ctgccgggcg cgccccgagg cctaccaggt ccccgcctca taccagcccg     1260

acgaggagga gcgagcgcgc ctggcgggcg aggaggaggc gctgcgtcag taccagcagc     1320

ggaagcagca gcagcaggag gggaactacc tgcagcacgt ccagctggac cagaggagcc     1380

tggtgctgaa cacggagccc gccgagtgcc ccgtgtgcta ctcggtgctg gcgcccggcg     1440

aggccgtggt gctgcgtgag tgtctgcaca ccttctgcag ggagtgcctg cagggcacca     1500

tccgcaacag ccaggaggcg gaggtctcct gccccttcat tgacaacacc tactcgtgct     1560

cgggcaagct gctggagagg gagatcaagg cgctcctgac ccctgaggat taccagcgat     1620

ttctagacct gggcatctcc attgctgaaa accgcagtgc cttcagctac cattgcaaga     1680

ccccagattg caagggatgg tgcttctttg aggatgatgt caatgagttc acctgccctg     1740

tgtgtttcca cgtcaactgc ctgctctgca aggccatcca tgagcagatg aactgcaagg     1800

agtatcagga ggacctggcc ctgcgggctc agaacgatgt ggctgcccgg cagacgacag     1860

agatgctgaa ggtgatgctg cagcagggcg aggccatgcg ctgcccccag tgccagatcg     1920

tggtacagaa gaaggacggc tgcgactgga tccgctgcac cgtctgccac accgagatct     1980

gctgggtcac caagggccca cgctggggcc ctgggggccc aggagacacc agcgggggct     2040

gccgctgcag ggtaaatggg attccttgcc acccaagctg tcagaactgc cactgagcta     2100

aagatggtgg ggccacatgc tgacccagcc ccacatccac attctgttag aatgtagctc     2160

agggagcttc gtggacggcc ttgcttgctg tagcgttgta ggggccctgc ctgcactgcg     2220

gttgtccacg gtcacatctg ccccagtgcc tttgtccttc ccttggggct tgccggccag     2280

acttctctcc cctgcggctc ccacctctgc ctgaccccag ccttaaacat agcccctggc     2340

cagaggcctt gctgggtgga gcctctgtgt gactccatac tcctcccacc acaacactca     2400

tctgtcaaac accaagcact ctcagcctcc ccgccttcag ctgtcagctt tctggggcta     2460

acttctctgc ctttgtggtt ggaggcctga ggcctcttgg aactcttgct aacctgttca     2520

gagccaggaa ggagactgca cagttttgaa agcacagccc gtcaggtccg gctctgcgtc     2580

tccctctctg cagcctgtgt aagctattat aattaaaatg gttttccggg aagggatgag     2640

tgtgatgtcc ttgagaggaa atgaatgtcc tggcctggga ctctacacac aggcaggatc     2700

ctgaggtctc tgggaactgc atcagaaagt tgacttgtca gtccatctgt ggtagaatga     2760

ggctgtgact gagcactggg acctttctac cagatgtgga ccccatgccc agcctcaggg     2820

gcaaggatgc tcttgggtca ccgtcagcca ggacaggtgg agtgtgcagt gtgtcaagtc     2880

tgcagagaag gatgggctta ggggcgggag gggaagtctt gccactcctg ctcccttttg     2940

acctctcagc aggcatctag ggttggcagg tagatagttc aagaaggaac gaagctgctg     3000

cagttgaggg gtggggttgt ccatcctatt ttctcgtctc aagcaagatg gcacagtatc     3060

gattcagcag tatttactag aacccactct gtgctggtcg gaggttacta agacagggtc     3120

ctgggatgtt cattctctaa gtctttcctc cgctctgtga cccaccctcc ttcccctttt     3180

gagatctggt atttgatgcc caacacattg tccacgctgt gacgtgacca tcatcatagc     3240

aggcagaggg cgcctctgct gctgaaggcc tgtgattttg tggggaaggg cctgttctag     3300

caactggaaa ggcactgcca cctgccgttg gatgccagga ctcaagagct ggccccagtc     3360

actgtgcgca gagctgtctg agaatgtgtg agtggactgg gtccttcggc actgcctgca     3420

ttggctcagg gcagtcaacc gtcgcagagg atgaggggca cactcaggca gcctccccgg     3480

ccctggaggc agaaaggccc aggcagaacc actgactggg aggaaacaga aaaagcagag     3540

gagagccagg ctgcaggcgt gtggatggga ccagctcagg cagacgctgt ctcataccca     3600

ctctcccctc tcttgccagg gcctggcctg gtgtctctca ggagcctggg catgagacaa     3660

aagcagagat tgttctcttg tggtaccaca ggctgtaacc agtccaccca gtgttgtttt     3720

agaaatttaa atcggttgcc catcttttta aattggcaac atcgtttacc acattaaaat     3780

ctagatgccc tgcttctctt gaaaaaaaaa aaaaaaaa                             3818


<210>  37
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Thr Ala Thr Pro Asp Gly Arg Glu Asp Gln Glu Arg Leu Trp 
1               5                   10                  15      


Val Ser Val Glu Asp Ala Gln Met His Thr Val Thr Ile Trp Leu Thr 
            20                  25                  30          


Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met Val Phe Leu 
        35                  40                  45              


Asp Tyr Gly Phe Pro Pro Val Leu Gln Gln Trp Val Ile Gly Gln Arg 
    50                  55                  60                  


Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Val Arg Gln Asn 
65                  70                  75                  80  


Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu 
                85                  90                  95      


Asn Pro Gln Glu Leu Gln Arg Glu Arg Gln Leu Arg Met Leu Glu Asp 
            100                 105                 110         


Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro 
        115                 120                 125             


Gly Pro Pro Lys Pro Gly Val Pro Gln Glu Pro Gly Arg Gly Gln Pro 
    130                 135                 140                 


Asp Ala Val Pro Glu Pro Pro Pro Val Gly Trp Gln Cys Pro Gly Cys 
145                 150                 155                 160 


Thr Phe Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met Cys Cys Arg 
                165                 170                 175     


Ala Arg Pro Glu Ala Tyr Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu 
            180                 185                 190         


Glu Glu Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr 
        195                 200                 205             


Gln Gln Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu Gln His Val 
    210                 215                 220                 


Gln Leu Asp Gln Arg Ser Leu Val Leu Asn Thr Glu Pro Ala Glu Cys 
225                 230                 235                 240 


Pro Val Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val Val Leu Arg 
                245                 250                 255     


Glu Cys Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg 
            260                 265                 270         


Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr 
        275                 280                 285             


Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr 
    290                 295                 300                 


Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu 
305                 310                 315                 320 


Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp Cys Lys Gly 
                325                 330                 335     


Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys 
            340                 345                 350         


Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Gln Met Asn 
        355                 360                 365             


Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln Asn Asp Val 
    370                 375                 380                 


Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly 
385                 390                 395                 400 


Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln Lys Lys Asp 
                405                 410                 415     


Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp 
            420                 425                 430         


Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser 
        435                 440                 445             


Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys 
    450                 455                 460                 


Gln Asn Cys His 
465             


<210>  38
<211>  3963
<212>  DNA
<213>  Homo sapiens

<400>  38
ccccgcctgc ggcccagctc cttcccgcgg ctctgcgatg cggcccgcag ggtgacccgg       60

gcgggagtcc ggggacccgc gatcagcccc ggaggacggg gtggggtcgc cccaaacagg      120

agcgccggga ccgctgggac cccgcactcg gcgtccgccg ccgccgggta gccgggcagt      180

ggaggtcccg gatgaggcga caatttttcc ggccccccct cccagtcccg ccccacttcc      240

ggggccgcca ctttcacttt ctcttccgcc gaagccgctc cccttgcgaa gaactggggc      300

ctcccgggag gagagagggc tttgccttga aacccgggac gccaggggcg ctcccgcaag      360

tgggggtcct ccgggacttg gaacgccccg gctgggtggt gtccgggcgt cctttccccg      420

cttcttccca cctcggctgg tcccgtttcc tcctgcgccc agtgcggacc tgtctcggcg      480

cccgctgccc tctcaccgcc ccacgcagga tcccggcctg gtcaccgggc agtgtgatgc      540

ttcccgactg ccgcggggac agcgaggcac acacagggct tgggccgcgc cggaggccac      600

acggcctggc tgagttgctc ctggtctccc gcctctccca ggcgacccgg aggtagcatt      660

tcccaggagg cacggtcccc cccaggggga tgggcacagc cacgccagat ggacgagaag      720

accaagaaag cagaggaaat ggccctgagc ctcacccgag cagtggcggg cggggatgaa      780

caggtggcaa tgaagtgtgc catctggctg gcagagcaac gggtgcccct gagtgtgcaa      840

ctgaagcctg aggtctcccc aacgcaggac atcaggctgt gggtgagcgt ggaggatgct      900

cagatgcaca ccgtcaccat ctggctcaca gtgcgccctg atatgacagt ggcgtctctc      960

aaggacatgg tttttctgga ctatggcttc ccaccagtct tgcagcagtg ggtgattggg     1020

cagcggctgg cacgagacca ggagaccctg cactcccatg gggtgcggca gaatggggac     1080

agtgcctacc tctatctgct gtcagcccgc aacacctccc tcaaccctca ggagctgcag     1140

cgggagcggc agctgcggat gctggaagat ctgggcttca aggacctcac gctgcagccg     1200

cggggccctc tggagccagg ccccccaaag cccggggtcc cccaggaacc cggacggggg     1260

cagccagatg cagtgcctga gcccccaccg gtgggctggc agtgccccgg gtgcaccttc     1320

atcaacaagc ccacgcggcc tggctgtgag atgtgctgcc gggcgcgccc cgaggcctac     1380

caggtccccg cctcatacca gcccgacgag gaggagcgag cgcgcctggc gggcgaggag     1440

gaggcgctgc gtcagtacca gcagcggaag cagcagcagc aggaggggaa ctacctgcag     1500

cacgtccagc tggaccagag gagcctggtg ctgaacacgg agcccgccga gtgccccgtg     1560

tgctactcgg tgctggcgcc cggcgaggcc gtggtgctgc gtgagtgtct gcacaccttc     1620

tgcagggagt gcctgcaggg caccatccgc aacagccagg aggcggaggt ctcctgcccc     1680

ttcattgaca acacctactc gtgctcgggc aagctgctgg agagggagat caaggcgctc     1740

ctgacccctg aggattacca gcgatttcta gacctgggca tctccattgc tgaaaaccgc     1800

agtgccttca gctaccattg caagacccca gattgcaagg gatggtgctt ctttgaggat     1860

gatgtcaatg agttcacctg ccctgtgtgt ttccacgtca actgcctgct ctgcaaggcc     1920

atccatgagc agatgaactg caaggagtat caggaggacc tggccctgcg ggctcagaac     1980

gatgtggctg cccggcagac gacagagatg ctgaaggtga tgctgcagca gggcgaggcc     2040

atgcgctgcc cccagtgcca gatcgtggta cagaagaagg acggctgcga ctggatccgc     2100

tgcaccgtct gccacaccga gatctgctgg gtcaccaagg gcccacgctg gggccctggg     2160

ggcccaggag acaccagcgg gggctgccgc tgcagggtaa atgggattcc ttgccaccca     2220

agctgtcaga actgccactg agctaaagat ggtggggcca catgctgacc cagccccaca     2280

tccacattct gttagaatgt agctcaggga gcttcgtgga cggccttgct tgctgtagcg     2340

ttgtaggggc cctgcctgca ctgcggttgt ccacggtcac atctgcccca gtgcctttgt     2400

ccttcccttg gggcttgccg gccagacttc tctcccctgc ggctcccacc tctgcctgac     2460

cccagcctta aacatagccc ctggccagag gccttgctgg gtggagcctc tgtgtgactc     2520

catactcctc ccaccacaac actcatctgt caaacaccaa gcactctcag cctccccgcc     2580

ttcagctgtc agctttctgg ggctaacttc tctgcctttg tggttggagg cctgaggcct     2640

cttggaactc ttgctaacct gttcagagcc aggaaggaga ctgcacagtt ttgaaagcac     2700

agcccgtcag gtccggctct gcgtctccct ctctgcagcc tgtgtaagct attataatta     2760

aaatggtttt ccgggaaggg atgagtgtga tgtccttgag aggaaatgaa tgtcctggcc     2820

tgggactcta cacacaggca ggatcctgag gtctctggga actgcatcag aaagttgact     2880

tgtcagtcca tctgtggtag aatgaggctg tgactgagca ctgggacctt tctaccagat     2940

gtggacccca tgcccagcct caggggcaag gatgctcttg ggtcaccgtc agccaggaca     3000

ggtggagtgt gcagtgtgtc aagtctgcag agaaggatgg gcttaggggc gggaggggaa     3060

gtcttgccac tcctgctccc ttttgacctc tcagcaggca tctagggttg gcaggtagat     3120

agttcaagaa ggaacgaagc tgctgcagtt gaggggtggg gttgtccatc ctattttctc     3180

gtctcaagca agatggcaca gtatcgattc agcagtattt actagaaccc actctgtgct     3240

ggtcggaggt tactaagaca gggtcctggg atgttcattc tctaagtctt tcctccgctc     3300

tgtgacccac cctccttccc cttttgagat ctggtatttg atgcccaaca cattgtccac     3360

gctgtgacgt gaccatcatc atagcaggca gagggcgcct ctgctgctga aggcctgtga     3420

ttttgtgggg aagggcctgt tctagcaact ggaaaggcac tgccacctgc cgttggatgc     3480

caggactcaa gagctggccc cagtcactgt gcgcagagct gtctgagaat gtgtgagtgg     3540

actgggtcct tcggcactgc ctgcattggc tcagggcagt caaccgtcgc agaggatgag     3600

gggcacactc aggcagcctc cccggccctg gaggcagaaa ggcccaggca gaaccactga     3660

ctgggaggaa acagaaaaag cagaggagag ccaggctgca ggcgtgtgga tgggaccagc     3720

tcaggcagac gctgtctcat acccactctc ccctctcttg ccagggcctg gcctggtgtc     3780

tctcaggagc ctgggcatga gacaaaagca gagattgttc tcttgtggta ccacaggctg     3840

taaccagtcc acccagtgtt gttttagaaa tttaaatcgg ttgcccatct ttttaaattg     3900

gcaacatcgt ttaccacatt aaaatctaga tgccctgctt ctcttgaaaa aaaaaaaaaa     3960

aaa                                                                   3963


<210>  39
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Thr 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Val Ala Met Lys Cys Ala Ile 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Ser Val Gln Leu Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Leu Trp Val Ser Val Glu Asp Ala 
    50                  55                  60                  


Gln Met His Thr Val Thr Ile Trp Leu Thr Val Arg Pro Asp Met Thr 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asp Met Val Phe Leu Asp Tyr Gly Phe Pro Pro 
                85                  90                  95      


Val Leu Gln Gln Trp Val Ile Gly Gln Arg Leu Ala Arg Asp Gln Glu 
            100                 105                 110         


Thr Leu His Ser His Gly Val Arg Gln Asn Gly Asp Ser Ala Tyr Leu 
        115                 120                 125             


Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu Asn Pro Gln Glu Leu Gln 
    130                 135                 140                 


Arg Glu Arg Gln Leu Arg Met Leu Glu Asp Leu Gly Phe Lys Asp Leu 
145                 150                 155                 160 


Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro Gly Pro Pro Lys Pro Gly 
                165                 170                 175     


Val Pro Gln Glu Pro Gly Arg Gly Gln Pro Asp Ala Val Pro Glu Pro 
            180                 185                 190         


Pro Pro Val Gly Trp Gln Cys Pro Gly Cys Thr Phe Ile Asn Lys Pro 
        195                 200                 205             


Thr Arg Pro Gly Cys Glu Met Cys Cys Arg Ala Arg Pro Glu Ala Tyr 
    210                 215                 220                 


Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu Arg Ala Arg Leu 
225                 230                 235                 240 


Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr Gln Gln Arg Lys Gln Gln 
                245                 250                 255     


Gln Gln Glu Gly Asn Tyr Leu Gln His Val Gln Leu Asp Gln Arg Ser 
            260                 265                 270         


Leu Val Leu Asn Thr Glu Pro Ala Glu Cys Pro Val Cys Tyr Ser Val 
        275                 280                 285             


Leu Ala Pro Gly Glu Ala Val Val Leu Arg Glu Cys Leu His Thr Phe 
    290                 295                 300                 


Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser Gln Glu Ala Glu 
305                 310                 315                 320 


Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr Ser Cys Ser Gly Lys Leu 
                325                 330                 335     


Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr Pro Glu Asp Tyr Gln Arg 
            340                 345                 350         


Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu Asn Arg Ser Ala Phe Ser 
        355                 360                 365             


Tyr His Cys Lys Thr Pro Asp Cys Lys Gly Trp Cys Phe Phe Glu Asp 
    370                 375                 380                 


Asp Val Asn Glu Phe Thr Cys Pro Val Cys Phe His Val Asn Cys Leu 
385                 390                 395                 400 


Leu Cys Lys Ala Ile His Glu Gln Met Asn Cys Lys Glu Tyr Gln Glu 
                405                 410                 415     


Asp Leu Ala Leu Arg Ala Gln Asn Asp Val Ala Ala Arg Gln Thr Thr 
            420                 425                 430         


Glu Met Leu Lys Val Met Leu Gln Gln Gly Glu Ala Met Arg Cys Pro 
        435                 440                 445             


Gln Cys Gln Ile Val Val Gln Lys Lys Asp Gly Cys Asp Trp Ile Arg 
    450                 455                 460                 


Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr Lys Gly Pro Arg 
465                 470                 475                 480 


Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly Cys Arg Cys Arg 
                485                 490                 495     


Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn Cys His 
            500                 505                 510 


<210>  40
<211>  3802
<212>  DNA
<213>  Homo sapiens

<400>  40
ccccgcctgc ggcccagctc cttcccgcgg ctctgcgatg cggcccgcag ggtgacccgg       60

gcgggagtcc ggggacccgc gatcagcccc ggaggacggg gtggggtcgc cccaaacagg      120

agcgccggga ccgctgggac cccgcactcg gcgtccgccg ccgccgggta gccgggcagt      180

ggaggtcccg gatgaggcga caatttttcc ggccccccct cccagtcccg ccccacttcc      240

ggggccgcca ctttcacttt ctcttccgcc gaagccgctc cccttgcgaa gaactggggc      300

ctcccgggag gagagagggc tttgccttga aacccgggac gccaggggcg ctcccgcaag      360

tgggggtcct ccgggacttg gaacgccccg gctgggtggt gtccgggcgt cctttccccg      420

cttcttccca cctcggctgg tcccgtttcc tcctgcgccc agtgcggacc tgtctcggcg      480

cccgctgccc tctcaccgcc ccacgcagga tcccggcctg gtcaccgggc agtgtgatgc      540

ttcccgactg ccgcggggac agcgaggcac acacagggct tgggccgcgc cggaggccac      600

acggcctggc tgagttgctc ctggtctccc gcctctccca ggcgacccgg aggtagcatt      660

tcccaggagg cacggtcccc cccaggggga tgggcacagc cacgccagat ggacgagaag      720

accaagaaag cagaggaaat ggccctgagc ctcacccgag cagtggcggg cggggatgaa      780

caggtggcaa tgaagtgtgc catctggctg gcagagcaac gggtgcccct gagtgtgcaa      840

ctgaagcctg aggtctcccc aacgcaggac atcaggctgt gggtgagcgt ggaggatgct      900

cagatgcaca ccgtcaccat ctggctcaca gtgcgccctg atatgacagt ggcgtctctc      960

aaggacatgg tttttctgga ctatggcttc ccaccagtct tgcagcagtg ggtgattggg     1020

cagcggctgg cacgagacca ggagaccctg cactcccatg gggtgcggca gaatggggac     1080

agtgcctacc tctatctgct gtcagcccgc aacacctccc tcaaccctca ggagctgcag     1140

cgggagcggc agctgcggat gctggaagat ctgggcttca aggacctcac gctgcagccg     1200

cggggccctc tggagccagg ccccccaaag cccggggtcc cccaggaacc cggacggggg     1260

cagccagatg cagtgcctga gcccccaccg gtgggctggc agtgccccgg gtgcaccttc     1320

atcaacaagc ccacgcggcc tggctgtgag atgtgctgcc gggcgcgccc cgaggcctac     1380

caggtccccg cctcatacca gcccgacgag gaggagcgag cgcgcctggc gggcgaggag     1440

gaggcgctgc gtcagtacca gcagggagtg cctgcagggc accatccgca acagccagga     1500

ggcggaggtc tcctgcccct tcattgacaa cacctactcg tgctcgggca agctgctgga     1560

gagggagatc aaggcgctcc tgacccctga ggattaccag cgatttctag acctgggcat     1620

ctccattgct gaaaaccgca gtgccttcag ctaccattgc aagaccccag attgcaaggg     1680

atggtgcttc tttgaggatg atgtcaatga gttcacctgc cctgtgtgtt tccacgtcaa     1740

ctgcctgctc tgcaaggcca tccatgagca gatgaactgc aaggagtatc aggaggacct     1800

ggccctgcgg gctcagaacg atgtggctgc ccggcagacg acagagatgc tgaaggtgat     1860

gctgcagcag ggcgaggcca tgcgctgccc ccagtgccag atcgtggtac agaagaagga     1920

cggctgcgac tggatccgct gcaccgtctg ccacaccgag atctgctggg tcaccaaggg     1980

cccacgctgg ggccctgggg gcccaggaga caccagcggg ggctgccgct gcagggtaaa     2040

tgggattcct tgccacccaa gctgtcagaa ctgccactga gctaaagatg gtggggccac     2100

atgctgaccc agccccacat ccacattctg ttagaatgta gctcagggag cttcgtggac     2160

ggccttgctt gctgtagcgt tgtaggggcc ctgcctgcac tgcggttgtc cacggtcaca     2220

tctgccccag tgcctttgtc cttcccttgg ggcttgccgg ccagacttct ctcccctgcg     2280

gctcccacct ctgcctgacc ccagccttaa acatagcccc tggccagagg ccttgctggg     2340

tggagcctct gtgtgactcc atactcctcc caccacaaca ctcatctgtc aaacaccaag     2400

cactctcagc ctccccgcct tcagctgtca gctttctggg gctaacttct ctgcctttgt     2460

ggttggaggc ctgaggcctc ttggaactct tgctaacctg ttcagagcca ggaaggagac     2520

tgcacagttt tgaaagcaca gcccgtcagg tccggctctg cgtctccctc tctgcagcct     2580

gtgtaagcta ttataattaa aatggttttc cgggaaggga tgagtgtgat gtccttgaga     2640

ggaaatgaat gtcctggcct gggactctac acacaggcag gatcctgagg tctctgggaa     2700

ctgcatcaga aagttgactt gtcagtccat ctgtggtaga atgaggctgt gactgagcac     2760

tgggaccttt ctaccagatg tggaccccat gcccagcctc aggggcaagg atgctcttgg     2820

gtcaccgtca gccaggacag gtggagtgtg cagtgtgtca agtctgcaga gaaggatggg     2880

cttaggggcg ggaggggaag tcttgccact cctgctccct tttgacctct cagcaggcat     2940

ctagggttgg caggtagata gttcaagaag gaacgaagct gctgcagttg aggggtgggg     3000

ttgtccatcc tattttctcg tctcaagcaa gatggcacag tatcgattca gcagtattta     3060

ctagaaccca ctctgtgctg gtcggaggtt actaagacag ggtcctggga tgttcattct     3120

ctaagtcttt cctccgctct gtgacccacc ctccttcccc ttttgagatc tggtatttga     3180

tgcccaacac attgtccacg ctgtgacgtg accatcatca tagcaggcag agggcgcctc     3240

tgctgctgaa ggcctgtgat tttgtgggga agggcctgtt ctagcaactg gaaaggcact     3300

gccacctgcc gttggatgcc aggactcaag agctggcccc agtcactgtg cgcagagctg     3360

tctgagaatg tgtgagtgga ctgggtcctt cggcactgcc tgcattggct cagggcagtc     3420

aaccgtcgca gaggatgagg ggcacactca ggcagcctcc ccggccctgg aggcagaaag     3480

gcccaggcag aaccactgac tgggaggaaa cagaaaaagc agaggagagc caggctgcag     3540

gcgtgtggat gggaccagct caggcagacg ctgtctcata cccactctcc cctctcttgc     3600

cagggcctgg cctggtgtct ctcaggagcc tgggcatgag acaaaagcag agattgttct     3660

cttgtggtac cacaggctgt aaccagtcca cccagtgttg ttttagaaat ttaaatcggt     3720

tgcccatctt tttaaattgg caacatcgtt taccacatta aaatctagat gccctgcttc     3780

tcttgaaaaa aaaaaaaaaa aa                                              3802


<210>  41
<211>  3657
<212>  DNA
<213>  Homo sapiens

<400>  41
ccccgcctgc ggcccagctc cttcccgcgg ctctgcgatg cggcccgcag ggtgacccgg       60

gcgggagtcc ggggacccgc gatcagcccc ggaggacggg gtggggtcgc cccaaacagg      120

agcgccggga ccgctgggac cccgcactcg gcgtccgccg ccgccgggta gccgggcagt      180

ggaggtcccg gatgaggcga caatttttcc ggccccccct cccagtcccg ccccacttcc      240

ggggccgcca ctttcacttt ctcttccgcc gaagccgctc cccttgcgaa gaactggggc      300

ctcccgggag gagagagggc tttgccttga aacccgggac gccaggggcg ctcccgcaag      360

tgggggtcct ccgggacttg gaacgccccg gctgggtggt gtccgggcgt cctttccccg      420

cttcttccca cctcggctgg tcccgtttcc tcctgcgccc agtgcggacc tgtctcggcg      480

cccgctgccc tctcaccgcc ccacgcagga tcccggcctg gtcaccgggc agtgtgatgc      540

ttcccgactg ccgcggggac agcgaggcac acacagggct tgggccgcgc cggaggccac      600

acggcctggc tgagttgctc ctggtctccc gcctctccca ggcgacccgg aggtagcatt      660

tcccaggagg cacggtcccc cccaggggga tgggcacagc cacgccagat ggacgagaag      720

accaagaaag gctgtgggtg agcgtggagg atgctcagat gcacaccgtc accatctggc      780

tcacagtgcg ccctgatatg acagtggcgt ctctcaagga catggttttt ctggactatg      840

gcttcccacc agtcttgcag cagtgggtga ttgggcagcg gctggcacga gaccaggaga      900

ccctgcactc ccatggggtg cggcagaatg gggacagtgc ctacctctat ctgctgtcag      960

cccgcaacac ctccctcaac cctcaggagc tgcagcggga gcggcagctg cggatgctgg     1020

aagatctggg cttcaaggac ctcacgctgc agccgcgggg ccctctggag ccaggccccc     1080

caaagcccgg ggtcccccag gaacccggac gggggcagcc agatgcagtg cctgagcccc     1140

caccggtggg ctggcagtgc cccgggtgca ccttcatcaa caagcccacg cggcctggct     1200

gtgagatgtg ctgccgggcg cgccccgagg cctaccaggt ccccgcctca taccagcccg     1260

acgaggagga gcgagcgcgc ctggcgggcg aggaggaggc gctgcgtcag taccagcagg     1320

gagtgcctgc agggcaccat ccgcaacagc caggaggcgg aggtctcctg ccccttcatt     1380

gacaacacct actcgtgctc gggcaagctg ctggagaggg agatcaaggc gctcctgacc     1440

cctgaggatt accagcgatt tctagacctg ggcatctcca ttgctgaaaa ccgcagtgcc     1500

ttcagctacc attgcaagac cccagattgc aagggatggt gcttctttga ggatgatgtc     1560

aatgagttca cctgccctgt gtgtttccac gtcaactgcc tgctctgcaa ggccatccat     1620

gagcagatga actgcaagga gtatcaggag gacctggccc tgcgggctca gaacgatgtg     1680

gctgcccggc agacgacaga gatgctgaag gtgatgctgc agcagggcga ggccatgcgc     1740

tgcccccagt gccagatcgt ggtacagaag aaggacggct gcgactggat ccgctgcacc     1800

gtctgccaca ccgagatctg ctgggtcacc aagggcccac gctggggccc tgggggccca     1860

ggagacacca gcgggggctg ccgctgcagg gtaaatggga ttccttgcca cccaagctgt     1920

cagaactgcc actgagctaa agatggtggg gccacatgct gacccagccc cacatccaca     1980

ttctgttaga atgtagctca gggagcttcg tggacggcct tgcttgctgt agcgttgtag     2040

gggccctgcc tgcactgcgg ttgtccacgg tcacatctgc cccagtgcct ttgtccttcc     2100

cttggggctt gccggccaga cttctctccc ctgcggctcc cacctctgcc tgaccccagc     2160

cttaaacata gcccctggcc agaggccttg ctgggtggag cctctgtgtg actccatact     2220

cctcccacca caacactcat ctgtcaaaca ccaagcactc tcagcctccc cgccttcagc     2280

tgtcagcttt ctggggctaa cttctctgcc tttgtggttg gaggcctgag gcctcttgga     2340

actcttgcta acctgttcag agccaggaag gagactgcac agttttgaaa gcacagcccg     2400

tcaggtccgg ctctgcgtct ccctctctgc agcctgtgta agctattata attaaaatgg     2460

ttttccggga agggatgagt gtgatgtcct tgagaggaaa tgaatgtcct ggcctgggac     2520

tctacacaca ggcaggatcc tgaggtctct gggaactgca tcagaaagtt gacttgtcag     2580

tccatctgtg gtagaatgag gctgtgactg agcactggga cctttctacc agatgtggac     2640

cccatgccca gcctcagggg caaggatgct cttgggtcac cgtcagccag gacaggtgga     2700

gtgtgcagtg tgtcaagtct gcagagaagg atgggcttag gggcgggagg ggaagtcttg     2760

ccactcctgc tcccttttga cctctcagca ggcatctagg gttggcaggt agatagttca     2820

agaaggaacg aagctgctgc agttgagggg tggggttgtc catcctattt tctcgtctca     2880

agcaagatgg cacagtatcg attcagcagt atttactaga acccactctg tgctggtcgg     2940

aggttactaa gacagggtcc tgggatgttc attctctaag tctttcctcc gctctgtgac     3000

ccaccctcct tccccttttg agatctggta tttgatgccc aacacattgt ccacgctgtg     3060

acgtgaccat catcatagca ggcagagggc gcctctgctg ctgaaggcct gtgattttgt     3120

ggggaagggc ctgttctagc aactggaaag gcactgccac ctgccgttgg atgccaggac     3180

tcaagagctg gccccagtca ctgtgcgcag agctgtctga gaatgtgtga gtggactggg     3240

tccttcggca ctgcctgcat tggctcaggg cagtcaaccg tcgcagagga tgaggggcac     3300

actcaggcag cctccccggc cctggaggca gaaaggccca ggcagaacca ctgactggga     3360

ggaaacagaa aaagcagagg agagccaggc tgcaggcgtg tggatgggac cagctcaggc     3420

agacgctgtc tcatacccac tctcccctct cttgccaggg cctggcctgg tgtctctcag     3480

gagcctgggc atgagacaaa agcagagatt gttctcttgt ggtaccacag gctgtaacca     3540

gtccacccag tgttgtttta gaaatttaaa tcggttgccc atctttttaa attggcaaca     3600

tcgtttacca cattaaaatc tagatgccct gcttctcttg aaaaaaaaaa aaaaaaa        3657


<210>  42
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Cys Gly Arg Met Gly Thr Val Pro Thr Ser Ile Cys Cys Gln 
1               5                   10                  15      


Pro Ala Thr Pro Pro Ser Thr Leu Arg Ser Cys Ser Gly Ser Gly Ser 
            20                  25                  30          


Cys Gly Cys Trp Lys Ile Trp Ala Ser Arg Thr Ser Arg Cys Ser Arg 
        35                  40                  45              


Gly Ala Leu Trp Ser Gln Ala Pro Gln Ser Pro Gly Ser Pro Arg Asn 
    50                  55                  60                  


Pro Asp Gly Gly Ser Gln Met Gln Cys Leu Ser Pro His Arg Trp Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Gly Ala Pro Ser Ser Thr Ser Pro Arg Gly Leu Ala 
                85                  90                  95      


Val Arg Cys Ala Ala Gly Arg Ala Pro Arg Pro Thr Arg Ser Pro Pro 
            100                 105                 110         


His Thr Ser Pro Thr Arg Arg Ser Glu Arg Ala Trp Arg Ala Arg Arg 
        115                 120                 125             


Arg Arg Cys Val Ser Thr Ser Arg Glu Cys Leu Gln Gly Thr Ile Arg 
    130                 135                 140                 


Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr 
145                 150                 155                 160 


Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr 
                165                 170                 175     


Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu 
            180                 185                 190         


Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp Cys Lys Gly 
        195                 200                 205             


Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys 
    210                 215                 220                 


Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Gln Met Asn 
225                 230                 235                 240 


Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln Asn Asp Val 
                245                 250                 255     


Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly 
            260                 265                 270         


Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln Lys Lys Asp 
        275                 280                 285             


Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp 
    290                 295                 300                 


Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser 
305                 310                 315                 320 


Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys 
                325                 330                 335     


Gln Asn Cys His 
            340 


<210>  43
<211>  1274
<212>  DNA
<213>  Homo sapiens

<400>  43
ccccgcctgc ggcccagctc cttcccgcgg ctctgcgatg cggcccgcag ggtgacccgg       60

gcgggagtcc ggggacccgc gatcagcccc ggaggacggg gtggggtcgc cccaaacagg      120

agcgccggga ccgctgggac cccgcactcg gcgtccgccg ccgccgggta gccgggcagt      180

ggaggtcccg gatgaggcga caatttttcc ggccccccct cccagtcccg ccccacttcc      240

ggggccgcca ctttcacttt ctcttccgcc gaagccgctc cccttgcgaa gaactggggc      300

ctcccgggag gagagagggc tttgccttga aacccgggac gccaggggcg ctcccgcaag      360

tgggggtcct ccgggacttg gaacgccccg gctgggtggt gtccgggcgt cctttccccg      420

cttcttccca cctcggctgg tcccgtttcc tcctgcgccc agtgcggacc tgtctcggcg      480

cccgctgccc tctcaccgcc ccacgcagga tcccggcctg gtcaccgggc agtgtgatgc      540

ttcccgactg ccgcggggac agcgaggcac acacagggct tgggccgcgc cggaggccac      600

acggcctggc tgagttgctc ctggtctccc gcctctccca ggcgacccgg aggtagcatt      660

tcccaggagg cacggtcccc cccaggggga tgggcacagc cacgccagat ggacgagaag      720

accaagaaag cagaggaaat ggccctgagc ctcacccgag cagtggcggg cggggatgaa      780

caggtggcaa tgaagtgtgc catctggctg gcagagcaac gggtgcccct gagtgtgcaa      840

ctgaagcctg aggtctcccc aacgcaggac atcagattcc tcatggtgca aaatggccat      900

tccagctcca tccagccatc acatcacagg aggaagggaa gaaagacacc cctccacact      960

cttctaaaga gcatagctca aaaattgtac acacttcttc cgttaattcc tgtggaccag     1020

aactgattcc cacagctaca gttcagcttg aggggagact gtatagccaa gatattcagc     1080

tagaattcag gggttcgctt ggtaagggaa gggaagagaa tggatactgt cggtctgtgc     1140

tccaggagac ttaaactcaa tgctgaaaca ctttgcacaa tgcctggcgt gttatgcact     1200

caataataaa cattagtgtc tatcgttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaa                                                       1274


<210>  44
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Thr 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Val Ala Met Lys Cys Ala Ile 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Ser Val Gln Leu Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Phe Leu Met Val Gln Asn Gly His 
    50                  55                  60                  


Ser Ser Ser Ile Gln Pro Ser His His Arg Arg Lys Gly Arg Lys Thr 
65                  70                  75                  80  


Pro Leu His Thr Leu Leu Lys Ser Ile Ala Gln Lys Leu Tyr Thr Leu 
                85                  90                  95      


Leu Pro Leu Ile Pro Val Asp Gln Asn 
            100                 105 


<210>  45
<211>  2410
<212>  DNA
<213>  Mus musculus

<400>  45
cgctgctcgc gctgtcttcc gggtagcgcg agcctccggg ctggggttcc ggacgctagg       60

gcgcccgcgc cggctggctg gccggcctcc ctccgtccct cgcttttggg tcgtggttac      120

tcatcgccct ttgcagactt ggctcggggc ctccttcgct gtccgtgtcc ctcgcggggc      180

cccattggtt cccagtgccc ggcctcgggc cctgggcagt gtgatgctgc ccgagtgcgg      240

actggaacac acgcacgagg ccggctaggg cagagttgct tctaccttcc cgctctctcc      300

caggttacct caaagtagcg ttttccggaa gcagcagccc tttctgaggg gatgggcgca      360

gccaggccag atggacgaga agaccaagaa agcagaggag atggccctga gccttgcccg      420

ggcagtggct ggcggagatg aacaggctgc tatcaagtat gccacctggc tggcagagca      480

gagggtgccc ctcagggtgc aagtaaaacc cgaggtctcc ccaacacagg acatcaggct      540

ctgtgtgagt gtggaggatg cgtacatgca caccgtcacc atttggctca cagtacgccc      600

ggatatgaca gtggcctccc ttaaggacat ggtattcctg gactatggct tcccacctag      660

cctgcagcag tgggtggttg gacagaggct ggcacgagac caggagacct tgcattcaca      720

cggcattcgg cggaatggag acggtgccta tctctacctg ctgtcagccc gcaacacgtc      780

actcaaccca caagagctgc agcggcagcg gcaactgcga atgttggaag atttgggctt      840

caaggacctc acccttcagt cacgggggcc cttggaacct gtccttccga agcccaggac      900

caaccaggag ccgggacagc cagatgcagc accggagtca ccaccggtgg gctggcagtg      960

ccctggctgc actttcatca acaaacccac acggcctggg tgtgagatgt gctgtcgtgc     1020

aaggcctgag acctaccaga tacctgcttc ataccagcct gacgaggaag agcgagcacg     1080

cctggccggc gaggaggagg cgctgcgcca gtaccagcag cggaaacagc agcagcagga     1140

ggggaactac ctgcagcacg tgcagctgga gcagaggagc ctggtgctga acaccgaacc     1200

tactgagtgc cctgtgtgct actcagtgct ggcacccggc gaggccgtgg tgctgcgtga     1260

gtgtctgcac accttctgca gggagtgcct gcagggcacc atccgaaaca gccaggaggc     1320

ggaggtggct tgccccttca ttgacagcac ctactcatgc cccggcaagc tgctggagag     1380

agagatccgg gcgctcctgt cccctgagga ctaccagcgt ttcctggatc tgggtgtgtc     1440

catcgcagag aaccgaagca ccttgagcta ccactgcaag acccccgact gcaggggttg     1500

gtgcttcttt gaggatgatg tcaacgagtt cacctgtcct gtgtgcaccc gtgtcaactg     1560

cctgctctgc aaggccatcc atgagcacat gaattgcagg gagtaccaag acgacctggc     1620

cctgcgggct cagaatgatg tggctgcccg gcagacgaca gagatgctaa aggtaatgct     1680

gcagcagggc gaggccatgc actgcccaca gtgccggatt gtggtgcaga agaaggacgg     1740

ctgtgactgg atccgctgta cagtctgcca cactgagatc tgctgggtca ccaagggccc     1800

acgctggggc ccagggggcc caggggacac cagtggtggc tgccgctgcc gggtcaatgg     1860

gattccatgc cacccaagct gtcaaaactg ccactaagtc gacgatggtg gctctcatac     1920

tgacccagcc ccacatgtat agcagtgaac agcagggcta ggcaagggac tggcctggtt     1980

tggccccata cctttaggct tggtaaggga gaaagcccga gctgtactgc agtctgattg     2040

ctgtgttaca aggacccagc tgagctgatg tcattcgcac tgcctctgtt gcttctggct     2100

gaccagacct catggccctg cactagacac ccgaccctta ctagccacca gccttaatta     2160

aacacggcct tggcctaagg cctggctggc tagtgctctg agtgactcta ttttccctga     2220

gcttgctccc tgaggaccca ccacagcctc atcctttgcc ttgctggctt tctgggcacg     2280

tcttaaagct gatgtgaatc catccagggc ctaggtagat tggtaagtca ggaaacagcc     2340

catggggttc agctctgcat cctcctcttt aagtgaatta aagtggtttt cccagaaaaa     2400

aaaaaaaaaa                                                            2410


<210>  46
<211>  2251
<212>  DNA
<213>  Mus musculus

<400>  46
gcctggagtc ggccgggtgg gggagagggg ggggatcatg ggtccctaga ccaagtgact       60

ctggtccgcc caaccaagtg tggcgcgaaa gtgccaggag cagtctagag gtctgcccca      120

gttggtgacc ctgcagagtc tcgggttacc tcaaagtagc gttttccgga agcagcagcc      180

ctttctgagg ggatgggcgc agccaggcca gatggacgag aagaccaaga aagcagagga      240

gatggccctg agccttgccc gggcagtggc tggcggagat gaacaggctg ctatcaagta      300

tgccacctgg ctggcagagc agagggtgcc cctcagggtg caagtaaaac ccgaggtctc      360

cccaacacag gacatcaggc tctgtgtgag tgtggaggat gcgtacatgc acaccgtcac      420

catttggctc acagtacgcc cggatatgac agtggcctcc cttaaggaca tggtattcct      480

ggactatggc ttcccaccta gcctgcagca gtgggtggtt ggacagaggc tggcacgaga      540

ccaggagacc ttgcattcac acggcattcg gcggaatgga gacggtgcct atctctacct      600

gctgtcagcc cgcaacacgt cactcaaccc acaagagctg cagcggcagc ggcaactgcg      660

aatgttggaa gatttgggct tcaaggacct cacccttcag tcacgggggc ccttggaacc      720

tgtccttccg aagcccagga ccaaccagga gccgggacag ccagatgcag caccggagtc      780

accaccggtg ggctggcagt gccctggctg cactttcatc aacaaaccca cacggcctgg      840

gtgtgagatg tgctgtcgtg caaggcctga gacctaccag atacctgctt cataccagcc      900

tgacgaggaa gagcgagcac gcctggccgg cgaggaggag gcgctgcgcc agtaccagca      960

gcggaaacag cagcagcagg aggggaacta cctgcagcac gtgcagctgg agcagaggag     1020

cctggtgctg aacaccgaac ctactgagtg ccctgtgtgc tactcagtgc tggcacccgg     1080

cgaggccgtg gtgctgcgtg agtgtctgca caccttctgc agggagtgcc tgcagggcac     1140

catccgaaac agccaggagg cggaggtggc ttgccccttc attgacagca cctactcatg     1200

ccccggcaag ctgctggaga gagagatccg ggcgctcctg tcccctgagg actaccagcg     1260

tttcctggat ctgggtgtgt ccatcgcaga gaaccgaagc accttgagct accactgcaa     1320

gacccccgac tgcaggggtt ggtgcttctt tgaggatgat gtcaacgagt tcacctgtcc     1380

tgtgtgcacc cgtgtcaact gcctgctctg caaggccatc catgagcaca tgaattgcag     1440

ggagtaccaa gacgacctgg ccctgcgggc tcagaatgat gtggctgccc ggcagacgac     1500

agagatgcta aaggtaatgc tgcagcaggg cgaggccatg cactgcccac agtgccggat     1560

tgtggtgcag aagaaggacg gctgtgactg gatccgctgt acagtctgcc acactgagat     1620

ctgctgggtc accaagggcc cacgctgggg cccagggggc ccaggggaca ccagtggtgg     1680

ctgccgctgc cgggtcaatg ggattccatg ccacccaagc tgtcaaaact gccactaagt     1740

cgacgatggt ggctctcata ctgacccagc cccacatgta tagcagtgaa cagcagggct     1800

aggcaaggga ctggcctggt ttggccccat acctttaggc ttggtaaggg agaaagcccg     1860

agctgtactg cagtctgatt gctgtgttac aaggacccag ctgagctgat gtcattcgca     1920

ctgcctctgt tgcttctggc tgaccagacc tcatggccct gcactagaca cccgaccctt     1980

actagccacc agccttaatt aaacacggcc ttggcctaag gcctggctgg ctagtgctct     2040

gagtgactct attttccctg agcttgctcc ctgaggaccc accacagcct catcctttgc     2100

cttgctggct ttctgggcac gtcttaaagc tgatgtgaat ccatccaggg cctaggtaga     2160

ttggtaagtc aggaaacagc ccatggggtt cagctctgca tcctcctctt taagtgaatt     2220

aaagtggttt tcccagaaaa aaaaaaaaaa a                                    2251


<210>  47
<211>  448
<212>  PRT
<213>  Mus musculus

<400>  47

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Ala 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Ala Ala Ile Lys Tyr Ala Thr 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Arg Val Gln Val Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Leu Cys Val Ser Val Glu Asp Ala 
    50                  55                  60                  


Tyr Met His Thr Val Thr Ile Trp Leu Thr Val Arg Pro Asp Met Thr 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asp Met Val Phe Leu Asp Tyr Gly Phe Pro Pro 
                85                  90                  95      


Ser Leu Gln Gln Trp Val Val Gly Gln Arg Leu Ala Arg Asp Gln Glu 
            100                 105                 110         


Thr Leu His Ser His Gly Ile Arg Arg Asn Gly Asp Gly Ala Tyr Leu 
        115                 120                 125             


Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu Asn Pro Gln Glu Leu Gln 
    130                 135                 140                 


Arg Gln Arg Gln Leu Arg Met Leu Glu Asp Leu Gly Phe Lys Asp Leu 
145                 150                 155                 160 


Thr Leu Gln Ser Arg Gly Pro Leu Glu Pro Val Leu Pro Lys Pro Arg 
                165                 170                 175     


Thr Asn Gln Glu Pro Gly Gln Pro Asp Ala Ala Pro Glu Ser Pro Pro 
            180                 185                 190         


Val Gly Trp Gln Cys Pro Gly Cys Thr Phe Ile Asn Lys Pro Thr Arg 
        195                 200                 205             


Pro Gly Cys Glu Met Cys Cys Arg Ala Arg Pro Glu Thr Tyr Gln Ile 
    210                 215                 220                 


Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu Arg Ala Arg Leu Ala Gly 
225                 230                 235                 240 


Glu Glu Glu Ala Leu Arg Gln Tyr Gln Gln Arg Lys Gln Gln Gln Gln 
                245                 250                 255     


Glu Gly Asn Tyr Leu Gln His Val Gln Leu Glu Gln Arg Ser Leu Val 
            260                 265                 270         


Leu Asn Thr Glu Pro Thr Glu Cys Pro Val Cys Tyr Ser Val Leu Ala 
        275                 280                 285             


Pro Gly Glu Ala Val Val Leu Arg Glu Cys Leu His Thr Phe Cys Arg 
    290                 295                 300                 


Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser Gln Glu Ala Glu Val Ala 
305                 310                 315                 320 


Cys Pro Phe Ile Asp Ser Thr Tyr Ser Cys Pro Gly Lys Leu Leu Glu 
                325                 330                 335     


Arg Glu Ile Arg Ala Leu Leu Ser Pro Glu Asp Tyr Gln Arg Phe Leu 
            340                 345                 350         


Asp Leu Gly Val Ser Ile Ala Glu Gln Asn Asp Val Ala Ala Arg Gln 
        355                 360                 365             


Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly Glu Ala Met His 
    370                 375                 380                 


Cys Pro Gln Cys Arg Ile Val Val Gln Lys Lys Asp Gly Cys Asp Trp 
385                 390                 395                 400 


Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr Lys Gly 
                405                 410                 415     


Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly Cys Arg 
            420                 425                 430         


Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn Cys His 
        435                 440                 445             


<210>  48
<211>  8042
<212>  DNA
<213>  Homo sapiens

<400>  48
cacctcctcg cgcagggtca gaggccgtgg ggcgggccac ggtgacgcgc gcggaagcgc       60

tctgcgggcc ctcggaaacc gccccggcgg ctgagaggct gcggccactg cctggcaccc      120

cgacgggagg ggctccggat cgttcggagc cggctgaacc ccttcggccg cgagcgaccg      180

catgagtcgg gggactatgc cccagcccga agcgtggcca ggcgcgagct gcgccgagac      240

gccggcgcgg gaggcggcgg ccacggcgcg ggacggcggg aaggcggcgg ccagcgggca      300

gccgcggccc gagatgcagt gcccggccga gcatgaggag gacatgtacc gtgctgcaga      360

tgaaatagaa aaggagaaag aattgcttat acatgaaaga ggggcatcag aaccgagatt      420

aagcgtagct cctgaaatgg atatcatgga ctactgcaaa aaagaatgga gaggaaatac      480

acagaaagca acgtgtatga aaatgggcta tgaagaggtt tctcagaagt tcacctccat      540

acggcgagtc cgtggtgata attactgtgc actgagggcc acgctgttcc aggccatgag      600

ccaggctgtg gggctgccgc cctggctgca ggacccggag ctcatgctgt taccagaaaa      660

actcataagc aaatacaact ggatcaagca atggaaactt ggactgaaat ttgatgggaa      720

gaatgaggac ctggttgata aaattaaaga gtcccttact ctgctgagga agaagtgggc      780

aggcttggct gaaatgagaa ctgctgaagc aagacagata gcttgtgatg aactattcac      840

aaatgaggcg gaggaatata gcctctatga agctgtaaaa tttctaatgc taaacagagc      900

cattgaacta tataatgata aagagaaagg aaaggaagta ccatttttct ctgtgcttct      960

gtttgctcgg gacacatcaa atgacccagg acagcttctg aggaaccacc tcaaccaggt     1020

gggacacact ggtggtcttg aacaggttga aatgttcctt cttgcctatg ctgtgcgcca     1080

caccatccag gtgtaccggc tctccaagta caacacggaa gaattcatca cagtctaccc     1140

caccgaccca cccaaggact ggccagtggt aacgctcatt gctgaggacg atcggcacta     1200

taacatcccc gtcagagtgt gtgaggagac cagtctatga gagacgcatg ctcctgacag     1260

cctggcgacg tggcgaagat gcacaggtgg ctcctgggct tgggctgcag gtttgggggt     1320

ctctaagaac aatctctgag aagaaccctt gggcccctgg gagccaagtt ggacaggatg     1380

tcctgaagac tagcttttga taagagaaat taaccaagtc tttcccctca tctatgatgc     1440

aatatatttc agtgggggcc ttcagagcac acctgttgga cggtgcaaac catatcttct     1500

ccagaaggca aatacttttg tatcagagga aactcagttt tggagaggaa tatgttcttt     1560

atgtctcaaa tcaaaactct ctctaatggt aaactggctt ctaatttttt taagtacagt     1620

attttttttt cccctttagt agtaacgggt ttctatagat cttcctatac agtctgcttt     1680

aactcaggac cttgagatta tgagactgac gtgctgccca ctgcactgag ggggcttcta     1740

acagtctgct ttaagtggta taattctggg atagatctgt tactggcata gtcatgacaa     1800

cctctggtaa tcttaccttc tcctttttat gaagggaaga gcaatggttt ggacttacat     1860

cttaattaag gctattttaa gcagattgtt ttgcaacaga ttaagaattg ggtcccaaag     1920

tgggttattt caaggcattt ttgaagactg gaggagcgta ggagggagtg gtgagggaac     1980

ctagaacttc ttgctccttg tgactatgac agatgtctga tgcccccagc gcactggagt     2040

ctggggcttg gtgcaggtgg tgccccatca gtgtggacag acactacttg cctttgtggt     2100

ttagtgttgg aagctttaat tattctacag ttccatagat tcacaatttt atagccaaac     2160

agtttgtatc cacctgcttt cagaggagga accaaaggcc aaattacttt gaggtagggc     2220

ttagctggac ctgggttttc ctatgctctt ttcatgctgt gttggagggt gtgtccactg     2280

ccagatctgt gtaacccgtc tgggtcaggg gatgagtgac agcaaaccat cttaaaattt     2340

ttcatgagta catttaagcg gaagcatacg ggaatatgag tgcaaaagtg tggctgagcc     2400

gcgtatgccc ttgattggtt ttgggaagcc tgagggaggc agccttcctg gctatgagcc     2460

atcgcctgcc caatcaggct aagggtggtg actggggtgg tgaaggggca gctctgctga     2520

gcatggtctg ccttatggcc tgaattgtcc tcaaggggtg tggactgcag atggtgttca     2580

catgaaccgg agacatcact ctttaggatt ctactggcag cccctgaatt ggctcaacgt     2640

ttgtggaggt ggtatttccc tgaagtactg agctttgttt tataataatt aaaatcctta     2700

tttggtccaa tttaatatag tttagaagct attttttttg aggcaaaccg tttttgaaaa     2760

tgtaaatttt gtttttaatt aaaaataaag tcttagttaa gaaaactcag gatgcacaaa     2820

actattcaga ctgttacttt agctttctcc cattacctca tcagtaatat tcaccacatt     2880

ttgctaaata tttattgatt agagtgttga aatcaaattc tgctctaaat gtgtgtgaat     2940

atgttggaga ggctttgtgt tcttcactgt gaaatgcaat tgtgccttga ataagaaggt     3000

acctagaagc caaattaaag taataatgac ttcttattgg ctttgatttt tcattgcagt     3060

atatgggatt gtacagcagg aaatgcttat cattaatttc tgatgttttt taaagcacaa     3120

ctcgaaacat ttcgatcata catacatagc agtagagatc tgtgcccttc aggtacattg     3180

aatctgacca tcagtttata tatgtcattg aattttaaga atactcatgt taataatagt     3240

catctatcct tgcattttga aactgttcta atcttagtga acttgaattg gatttctggg     3300

taaaagaatg tgtttctttt atgttgctta tgtccgaagg ccttgtcaga atctgtcaga     3360

ctcttgttta ggtttagtgt gatcatggcg tcagagaagc aaagctttca aataaatagt     3420

acttcaggaa atagaaatga ttgaccaact ttaaaaataa ttttttttta attgcaatat     3480

gcagcttcag ttgcccagaa tcttagttcc gtttctcatt cttggtcttg agctggtcag     3540

gtgacatcag cagattagaa gttgaatgga gattaagtgg attcaggagg atgttccact     3600

tagagcagtc ttcaaaatga taaggtgttc tagaagaaag gaatgtagta ggaactatac     3660

tatgcctaac tttctatccc agagtgtctt gcaagagttt aggagttttg gaccctgtgt     3720

attggcagaa aagttatctc catcttaagc aggcatgact tttatacctg tgagctcatt     3780

taaggtgcat ttaaacctaa aataatttcc ctgtattatg cttcatggga ttaacactgc     3840

ttttccagaa cattttcaga ttcccctcct tacatcctga gctccttctg tatatacatc     3900

tgttgatttt atccatccac aaggaacaat gatagtcaca ttagagaaca agaaaccagt     3960

aatacatggt ctctaactga tgattcgggc ctggatttga ttgaaagtgt ttgcagttcc     4020

tcttccgtag aatacagagt ggatgaaaat gttttcaatg cacagaacag gatgaatcct     4080

tttttcttta tttagcgatt tacacttttg ttactctatt atatattcag ttagtgtctg     4140

ataagatttt ctttgcttaa ggagaacgga cattgccttg gtatgttttt tttttttttt     4200

ccctccactt ttggagctta tcaggtaaaa atctcaagcc acatgaattg ttaacacctc     4260

tgttgggaaa agcctttgtg agtttttatg tacttggtct ttgtttttgt tattcatcct     4320

gtgtcctccc tcttcccgat gtgctgtttt acctaggagt tagtctgctt tctgaggatc     4380

ttttagagag aggctgtgaa gtgctgaatc acctttaatg atacagcact tctgccatct     4440

cagcatctac ataggactta catagacttc ctgaatgtgt cttcttcaga tactaaagta     4500

cagttggatc attttcttat ctccttttct taagcagtac tttgcaggta ctcccctttg     4560

aaagccagaa gcataaacca ttggggaatc ttaacttgta gacatgcagt aaaagaaatg     4620

catttatgta agatctgtga gtacttaaaa agaaagccct cagtgtgtgt gaagtgaatg     4680

tgaaatgtgt gtgaaataca tagaattccc aaatagttta gcaaaggcag ggcgcaatat     4740

caagtaattt aaaaatggtc caaggaactg taagaaggag gaactaattc tagaataaat     4800

gttaaaatgc cattcaagaa caaaaccaca gatgccatac agacctcctg tgcttaagtt     4860

atagaagaat aaaaatctga atgaatggaa ggccttacgt gtatacagtt tacaaattcc     4920

tatttctaaa atttaagtcc cttatttaac agaagtatgt attttaatgc ttaactgtct     4980

cgggaaacct catttgtgac atcatctaag gggatgggaa gactagggag ccagtgccac     5040

gttgaacaga acagtggttt agtgaatgtg tgaggaaaga catgggcaac tgattattaa     5100

tgtttttgta attcagttta taacttggaa ccaatgaaaa gcaacaaaac taaactggtt     5160

tgacagcctg ccacttctgg catttcctgt aagtcactag cagtaggtgt gaggtgggct     5220

tgcccatgac caggaggggt gtgtgtgtgt gtgtgcatgt gtgtatatgc gtgttggtct     5280

gcagtcacag cataccttta tgtgcatgtg tcctcgcagc ttgggactca gcagtattct     5340

gggagggtgg aggtgaactg tcccatgtat tgtattatat attttttgag atggggtctt     5400

gctctgttgc ccaggctgga gtgcagtggt gcgatctcag ctcactgcaa cttttgcctc     5460

ctggttcaag cagttctcct gcctcagcct gccaaatagc tgggattaca ggtgtgtacc     5520

accactccca gctaattttt gtatttttag tagagatggg gttttaccat gttggccagg     5580

ctggtctcga gctcctggcc tcaggtgatc cacctgcttt ggcctcccaa agtgctgaga     5640

ttacaggcgt gaactaccgc gcctggcccc atgtattgta tttttttcag gttatattga     5700

aatctactac caggaatgtc ggaatgggtt ttggtatgta taatggaaat agatagagtg     5760

gttaagtcta gaaacacata cattaattgt attgaaatgt tatatcaata catcatttat     5820

gatgtgtgtg tggtcccaga cctcatggcc accagtttgt ttaagcattg tgaatgcttt     5880

ttaatagcat tcattagcat taatggagga ggacactgtg ttttctcaat taatctcatt     5940

gatttgtttg gtataagttt gggtcagaaa tgaaactgcc aaaacatcga tcagtacaag     6000

gaagggacac agggcttaaa atgtccacag tcttggcagt ggacttggca gttctcccag     6060

taagcagaag tacttgagct taattctgaa cttcaaagta atattttata cttaatttta     6120

ggagttttca tttacatatt gaaaaatgcc ttgactgtat tcacataaat ggtgctaaaa     6180

cattgtaccc cttataagaa ctgcagcaat ccacagtaat gttggttact tctgagtatt     6240

tgataaagga acaaagtcaa aatgaatgta tttaataagc ttctttctca tttccattgt     6300

ttttataaaa atattttggt attgttgcct gcattttagc cacttctaac tttttgtatt     6360

atgaatttgg agaggataac aagccaactt tagaccctct gccagtggcg atggtgtttt     6420

tcttccatgg gtaagccatt gtgaatggag gctggtggag cagcacactg tgtgaacctg     6480

gcagcgctca tcttggcttg tttagcagtg cctctgttta caccataaga tgttccgcat     6540

gtgtccaaaa tttcgcctgc tctgaaaaac atgcccccga ggctctgtgc agtttggggc     6600

cttggttccc acctgcagat gcggtcagtt gcctggctcc tggggccaga gtttcctctg     6660

ttacttgttg agtctcttgt cttcactgtc agaagctgaa ctgacttggg ggctttgctg     6720

ttgatccact ttagcaaacc ctgctgcaga ggactgtaaa aacaaataac taaaaataaa     6780

cttagaaaat acaactcaga agcctggctc tgttgctgtg gtcaaatgct tgcctttgag     6840

gactttggca gattgtgcta ttacattggg ctctaacttt ctggcacccg caaggcagac     6900

ctatgatgtc cacatggctg actcttgacc cctggccatt gtgagcagag gaatcaaggg     6960

tttagggagg cagtattggg cagtgtggaa gagttagatg agatgaagca gttagcacag     7020

tgcttaaccc atactaagtg cccccaaccc tgccagccaa attaggtgca tagttttcag     7080

cttgggtctg gattcaacag cattcccgct gcccactaaa agggtgggct tggacagttc     7140

ctgaacctcc ctaaatctgt ttcttcatct ttaccacaca cagtctgtct cagtggtggt     7200

gtggattaag tgaggtgcta gcacttatta ggggaagatc ctccagacct gcaaagcagg     7260

gctgcagccc caattctgac ccagccctgc tgtgtgtttg ccgcaaagag gtttggtgtg     7320

tgcgagacat ttctttatga accatttaca ctgctggaaa tgtacccact aatgtgatgg     7380

caagaacttc aacaaattgc ttatgaatca ggctctcaat ggaagaagtt aatcctctga     7440

agagggggaa gactggactt tcagaagtat gttggggata gagaatgaag tttgagtcag     7500

cagagctctg ccttcctgtt tgtcaaagaa ctagagtctg ggagtcttgc aagatggagc     7560

tgggcttctg aagaacccag tgggtaggta ctgggcatcc attagacggc agtgctaagt     7620

cggtcatgtg cagcagaaag acctccccac tgtgaacaac aaaccacttt cctcctccag     7680

tggcccattc atttggattg atacactttt tcagtgtcag aaatgcactt tctccctcta     7740

cttgtctgaa ttacgatgct ctgctcaact ctgtggacag tgtttcttga atttcctttt     7800

ccaccgcctt ttcccactca agaaagtgga gagaaaaaca gggatgcagg ctgtgggtct     7860

tgtggaagcc ctttacaacc attaaataaa gaacaccagc tgcattatgt gtgtttagaa     7920

cgagaagttg tttgtacagt atttttctat tgaccgcttc cgtcttgcct gaaacctggg     7980

cattctttct gtagtttctc tgaattttct gtctcacctc ctcaccccta cccttgcctt     8040

tt                                                                    8042


<210>  49
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Arg Gly Thr Met Pro Gln Pro Glu Ala Trp Pro Gly Ala Ser 
1               5                   10                  15      


Cys Ala Glu Thr Pro Ala Arg Glu Ala Ala Ala Thr Ala Arg Asp Gly 
            20                  25                  30          


Gly Lys Ala Ala Ala Ser Gly Gln Pro Arg Pro Glu Met Gln Cys Pro 
        35                  40                  45              


Ala Glu His Glu Glu Asp Met Tyr Arg Ala Ala Asp Glu Ile Glu Lys 
    50                  55                  60                  


Glu Lys Glu Leu Leu Ile His Glu Arg Gly Ala Ser Glu Pro Arg Leu 
65                  70                  75                  80  


Ser Val Ala Pro Glu Met Asp Ile Met Asp Tyr Cys Lys Lys Glu Trp 
                85                  90                  95      


Arg Gly Asn Thr Gln Lys Ala Thr Cys Met Lys Met Gly Tyr Glu Glu 
            100                 105                 110         


Val Ser Gln Lys Phe Thr Ser Ile Arg Arg Val Arg Gly Asp Asn Tyr 
        115                 120                 125             


Cys Ala Leu Arg Ala Thr Leu Phe Gln Ala Met Ser Gln Ala Val Gly 
    130                 135                 140                 


Leu Pro Pro Trp Leu Gln Asp Pro Glu Leu Met Leu Leu Pro Glu Lys 
145                 150                 155                 160 


Leu Ile Ser Lys Tyr Asn Trp Ile Lys Gln Trp Lys Leu Gly Leu Lys 
                165                 170                 175     


Phe Asp Gly Lys Asn Glu Asp Leu Val Asp Lys Ile Lys Glu Ser Leu 
            180                 185                 190         


Thr Leu Leu Arg Lys Lys Trp Ala Gly Leu Ala Glu Met Arg Thr Ala 
        195                 200                 205             


Glu Ala Arg Gln Ile Ala Cys Asp Glu Leu Phe Thr Asn Glu Ala Glu 
    210                 215                 220                 


Glu Tyr Ser Leu Tyr Glu Ala Val Lys Phe Leu Met Leu Asn Arg Ala 
225                 230                 235                 240 


Ile Glu Leu Tyr Asn Asp Lys Glu Lys Gly Lys Glu Val Pro Phe Phe 
                245                 250                 255     


Ser Val Leu Leu Phe Ala Arg Asp Thr Ser Asn Asp Pro Gly Gln Leu 
            260                 265                 270         


Leu Arg Asn His Leu Asn Gln Val Gly His Thr Gly Gly Leu Glu Gln 
        275                 280                 285             


Val Glu Met Phe Leu Leu Ala Tyr Ala Val Arg His Thr Ile Gln Val 
    290                 295                 300                 


Tyr Arg Leu Ser Lys Tyr Asn Thr Glu Glu Phe Ile Thr Val Tyr Pro 
305                 310                 315                 320 


Thr Asp Pro Pro Lys Asp Trp Pro Val Val Thr Leu Ile Ala Glu Asp 
                325                 330                 335     


Asp Arg His Tyr Asn Ile Pro Val Arg Val Cys Glu Glu Thr Ser Leu 
            340                 345                 350         


<210>  50
<211>  1491
<212>  DNA
<213>  Mus musculus

<400>  50
aagcgctctg cggacctcgc ggggtgcggg gcagcgcagc cacggctccg gacggcggga       60

cggcagggcc cggcgtggcc gcggatgagt cggggaacca tgccccagcc cggagcgtgg      120

cccggtgcaa gctgcgccga gacgccggcg cgcgaggccg gggccgcggc gcgggacggc      180

gggaaggtga cggccggcgc gcagccccgg gccgcgacgc gatgcccggc cgagcacgag      240

gaggacatgt accgtgctgc agatgaaata gaaaaggaga aagaattgct aatacatgaa      300

agagggatat cagaacccag gttaagtgtg gctcctgaaa tggatatcat ggactactgc      360

aaaaaagaat ggagaggaaa tactcagaaa gccacatgta tgaaaaaggg ctatgaggaa      420

gtgtctcaga aattcacttc cataaggcga gtccgtggtg ataactactg tgcactgagg      480

gccacactgt tccaggccat gagccagctg gccgagctgc ccccctggct gcaggacttg      540

gagctcatac tgttaccaga gaagctgata aacaagtata cctggatcaa gcagtggaaa      600

cttggactga aatttgatgg gaagagtgag gacctggttg aaaaaattaa ggaatccctt      660

gccctgctaa ggaagaagtg ggtaagcctg gctgcaatga aaactgctga agcgaggcag      720

acagcttgtg atgagctgtt caccaacgaa gaggaggagt acagcctcta cgaagctgtg      780

aagttcctga tgttaaacag agccatcgaa ctgtacgatg acaaggagaa gggaaaggaa      840

gtgccgttct tctctgtgct cttgtttgcc cgagacacat ccaatgaccc tgaacagctc      900

ctgaggaacc acctaaacca ggtgggacac acggggggcc ttgagcaggt tgagatgttc      960

cttcttgcct atgctgtccg ccacagcatc cgggtgtacc ggctgtccaa gtataacaca     1020

gaggagttca tcacagtcta ccccactgat ccccccaagg actggccaat ggtgaccctc     1080

atagctgagg atgatcggca ctataacatc cctgtcagag tgtgtgagga gaccagtgtg     1140

tgagggacac acatgtgact gccaagagat gcgcatgtgc agctcctcct ctgggggcct     1200

cagatctgca ggtctccaag gacaatctgg gagaactctc gggcccctgg agccaacttt     1260

ggaccattat gttctgaaga ctagctgttg ataatgagaa ttaattagcc aagccttcac     1320

tccttgttct gttatgcagt gtgttccact gggggcttca gcacgtgcct ttggaaggtg     1380

caaactatgt ctccataagg cggatgcttt tgggtcaaag aaaactgttt ggaaaggaat     1440

ctgtccaatg aaagttctga cggtaaactg gttttacttc tctttttaaa a              1491


<210>  51
<211>  352
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ser Arg Gly Thr Met Pro Gln Pro Gly Ala Trp Pro Gly Ala Ser 
1               5                   10                  15      


Cys Ala Glu Thr Pro Ala Arg Glu Ala Gly Ala Ala Ala Arg Asp Gly 
            20                  25                  30          


Gly Lys Val Thr Ala Gly Ala Gln Pro Arg Ala Ala Thr Arg Cys Pro 
        35                  40                  45              


Ala Glu His Glu Glu Asp Met Tyr Arg Ala Ala Asp Glu Ile Glu Lys 
    50                  55                  60                  


Glu Lys Glu Leu Leu Ile His Glu Arg Gly Ile Ser Glu Pro Arg Leu 
65                  70                  75                  80  


Ser Val Ala Pro Glu Met Asp Ile Met Asp Tyr Cys Lys Lys Glu Trp 
                85                  90                  95      


Arg Gly Asn Thr Gln Lys Ala Thr Cys Met Lys Lys Gly Tyr Glu Glu 
            100                 105                 110         


Val Ser Gln Lys Phe Thr Ser Ile Arg Arg Val Arg Gly Asp Asn Tyr 
        115                 120                 125             


Cys Ala Leu Arg Ala Thr Leu Phe Gln Ala Met Ser Gln Leu Ala Glu 
    130                 135                 140                 


Leu Pro Pro Trp Leu Gln Asp Leu Glu Leu Ile Leu Leu Pro Glu Lys 
145                 150                 155                 160 


Leu Ile Asn Lys Tyr Thr Trp Ile Lys Gln Trp Lys Leu Gly Leu Lys 
                165                 170                 175     


Phe Asp Gly Lys Ser Glu Asp Leu Val Glu Lys Ile Lys Glu Ser Leu 
            180                 185                 190         


Ala Leu Leu Arg Lys Lys Trp Val Ser Leu Ala Ala Met Lys Thr Ala 
        195                 200                 205             


Glu Ala Arg Gln Thr Ala Cys Asp Glu Leu Phe Thr Asn Glu Glu Glu 
    210                 215                 220                 


Glu Tyr Ser Leu Tyr Glu Ala Val Lys Phe Leu Met Leu Asn Arg Ala 
225                 230                 235                 240 


Ile Glu Leu Tyr Asp Asp Lys Glu Lys Gly Lys Glu Val Pro Phe Phe 
                245                 250                 255     


Ser Val Leu Leu Phe Ala Arg Asp Thr Ser Asn Asp Pro Glu Gln Leu 
            260                 265                 270         


Leu Arg Asn His Leu Asn Gln Val Gly His Thr Gly Gly Leu Glu Gln 
        275                 280                 285             


Val Glu Met Phe Leu Leu Ala Tyr Ala Val Arg His Ser Ile Arg Val 
    290                 295                 300                 


Tyr Arg Leu Ser Lys Tyr Asn Thr Glu Glu Phe Ile Thr Val Tyr Pro 
305                 310                 315                 320 


Thr Asp Pro Pro Lys Asp Trp Pro Met Val Thr Leu Ile Ala Glu Asp 
                325                 330                 335     


Asp Arg His Tyr Asn Ile Pro Val Arg Val Cys Glu Glu Thr Ser Val 
            340                 345                 350         


<210>  52
<211>  8040
<212>  DNA
<213>  Homo sapiens

<400>  52
ctcctccccg gcgcgctccc tgcccctcgc tccccgcagc cagcagagaa ggcggaagca       60

gtggcgtccg cagctggggc ttggcctgcg ggcggccagc gaaggtggcg aaggctccca      120

ctggatccag agtttgccgt ccaagcagcc tcgtctcggc gcgcagtgtc tgtgtccgtc      180

ctctaccagc gccttggctg agcggagtcg tgcggttggt gggggagccc tgccctcctg      240

gttcggcctc cccgcgcact agaacgatca tgaacttctg aagggaccca gctttctttg      300

tgtgctccaa gtgatttgca caaataataa tatatatatt tattgaagga gagaatcaga      360

gcaagtgata atcaagttac tatgagtctg ctaaactgtg aaaacagctg tggatccagc      420

cagtctgaaa gtgactgctg tgtggccatg gccagctcct gtagcgctgt aacaaaagat      480

gatagtgtgg gtggaactgc cagcacgggg aacctctcca gctcatttat ggaggagatc      540

cagggatatg atgtagagtt tgacccaccc ctggaaagca agtatgaatg ccccatctgc      600

ttgatggcat tacgagaagc agtgcaaacg ccatgcggcc ataggttctg caaagcctgc      660

atcataaaat caataaggga tgcaggtcac aaatgtccag ttgacaatga aatactgctg      720

gaaaatcaac tatttccaga caattttgca aaacgtgaga ttctttctct gatggtgaaa      780

tgtccaaatg aaggttgttt gcacaagatg gaactgagac atcttgagga tcatcaagca      840

cattgtgagt ttgctcttat ggattgtccc caatgccagc gtcccttcca aaaattccat      900

attaatattc acattctgaa ggattgtcca aggagacagg tttcttgtga caactgtgct      960

gcatcaatgg catttgaaga taaagagatc catgaccaga actgtccttt ggcaaatgtc     1020

atctgtgaat actgcaatac tatactcatc agagaacaga tgcctaatca ttatgatcta     1080

gactgcccta cagccccaat tccatgcaca ttcagtactt ttggttgcca tgaaaagatg     1140

cagaggaatc acttggcacg ccacctacaa gagaacaccc agtcacacat gagaatgttg     1200

gcccaggctg ttcatagttt gagcgttata cccgactctg ggtatatctc agaggtccgg     1260

aatttccagg aaactattca ccagttagag ggtcgccttg taagacaaga ccatcaaatc     1320

cgggagctga ctgctaaaat ggaaactcag agtatgtatg taagtgagct caaacgaacc     1380

attcgaaccc ttgaggacaa agttgctgaa atcgaagcac agcagtgcaa tggaatttat     1440

atttggaaga ttggcaactt tggaatgcat ttgaaatgtc aagaagagga gaaacctgtt     1500

gtgattcata gccctggatt ctacactggc aaacccgggt acaaactgtg catgcgcttg     1560

caccttcagt taccgactgc tcagcgctgt gcaaactata tatccctttt tgtccacaca     1620

atgcaaggag aatatgacag ccacctccct tggcccttcc agggtacaat acgccttaca     1680

attcttgatc agtctgaagc acctgtaagg caaaaccacg aagagataat ggatgccaaa     1740

ccagagctgc ttgctttcca gcgacccaca atcccacgga acccaaaagg ttttggctat     1800

gtaactttta tgcatctgga agccctaaga caaagaactt tcattaagga tgacacatta     1860

ttagtgcgct gtgaggtctc cacccgcttt gacatgggta gccttcggag ggagggtttt     1920

cagccacgaa gtactgatgc aggggtatag cttgccctca cttgctcaaa aacaactacc     1980

tggagaaaac agtgcctttc cttgccctgt tctcaataac atgcaaacaa acaagccacg     2040

ggaaatatgt aatatctact agtgagtgtt gttagagagg tcacttacta tttcttcctg     2100

ttacaaatga tctgaggcag ttttttcctg ggaatccaca cgttccatgc tttttcagaa     2160

atgttaggcc tgaagtgcct gtggcatgtt gcagcagcta ttttgccagt tagtatacct     2220

ctttgttgta ctttcttggg cttttgctct ggtgtatttt attgtcagaa agtccagact     2280

caagagtact aaacttttaa taataatgga ttttccttaa aacttcagtc tttttgtagt     2340

attatatgta atatattaaa agtgaaaatc actaccgcct tgtgctagtg ccctcgagaa     2400

gagttattgc tctagaaagt tgagttctca tttttttaac ctgttataga tttcagagga     2460

tttgaaccat aatccttgga aaacttaagt tctcattcac cccagttttt cctccaggtt     2520

gttactaagg atattcaggg atgagtttaa accctaaata taaccttaat tatttagtgt     2580

aaacatgtct gttgaataat acttgtttaa gtgttccttc tgccttgctt acttatttcc     2640

ttgaggttac gaagtagcat cttccccaga gtttataatg ctgagaacca cgtggatacc     2700

aactgctcat tgttatgcta tgtaaccctt tttgtctatt cagtgcagag tgaatttcac     2760

agctctgcat atgtcttcat ttgtttaatg cttacaagac aggagatgca cacatacaat     2820

cagcaacata aaaattaaaa gtgacccaag tagtcagcgc atgtggcatc tcattggtgg     2880

tgacagaagc tatgtgagcc agaagttttc agctcttttg aataccctct ggtttatttc     2940

gattaaaaag aacaaaattg atttcctaaa atcagaattt tttaaaactt gggagatgat     3000

tggagatacc taggaggtca ccaaactagg attagaagtc acagtggttg tatcacaact     3060

tagcttgagt atgttgctgt agcctaacaa ctgcaggttc tgagaaggat cctgtagaat     3120

cctggaagta accagatttt cctaataggg agatgatttt tttgtgtgcc atcatgtatt     3180

tgttaaaggc ctatatatag atataaaata tcgtggaatc tagttctcag ggagacccgc     3240

aactagtata agcttataaa ggatctaaag atccatccac catttaaagt tgtctggtaa     3300

tgagagatga cattgtatcc cccagagagg ccaaatcaga gtcgccagcc agcgttctag     3360

atcagcctta atttcaagag aaagccaagg acctcatctg caggggagtg tggttttcag     3420

ccccagcgag tgtcactttg aactttccct ttgctttttt ctctcttctc cctccccacc     3480

cacccttagg ctcctgatct ggtgagtttg ttatggagtg aaaataaaag tcaagcagag     3540

accttgtttc ccgtgccacc attagtacca caagctcatg gctagttacc acattacttc     3600

ctggcagttt gtgtccctca gctgtgcctt ccaaccagcg cctgagaatc actgcatacc     3660

accctctagg tagggaaacc tacactgctg ctgttcctgt gattatttta caatgaataa     3720

ataattgtca agttccattt aaaaactgaa cagtagtatt tttgtatttg cgtagaaaaa     3780

gcctgaagga aatatactaa actttttgtt ggcttatttt cctttgcgct tgcttatatt     3840

ttttacattt tctacaataa atgtgtactt ttatcggaga aaaaaattaa atgttgccac     3900

aaaacattta atctccacgc ccccagctca aaaaaggaaa tgatatttaa aagcttcctg     3960

gtcagatttc tattaaaagc actggctgtg cattagatac aaagaggagt catttcctgc     4020

cttggtgata ctattttttt ctactaactc aagagtcttt attaaaaaaa aaagttgttt     4080

tgcctaattt cagcttttag caagcttccc atctgtaaaa tgatttggac cagatatttc     4140

tagagtcccc tccagccata acattctgtc tcaaattaag ttccaaccag cagaacaatg     4200

acaatactta ggaaagtatt ttgccagtat aaaatgtctt taacttactc tttgctgaca     4260

ctgatacttt cctctaattt agtgtctatc agctgggtca catcttaagt aaaatgagca     4320

attttaaccc ccaacatttg gcattttgtc ataaaccagc cagttatttt atgctggtca     4380

ttcatcttga ctacaaagta gaatagtcaa gctgtcattc caaatagaaa actttttact     4440

tcaatcagaa ttaagcctta acctggaaag ttggtttctt ccttacattt tcccaatctc     4500

ctactctatt cttaaacatg ctagtttcac tcagttgggt atacaagcct ttgggcttta     4560

tgttgtatgt tactaaccac cttttaccat atttatcttt tggcatcatt ctgggacatt     4620

gctaaattaa aaaagaaatt gtttccactt ttttctggag atgttcaact aaaggttgtt     4680

ttgttttgtt ttttgttttg agacagtctc accctgacgc tcaggctgga gtgcagtggt     4740

gcaacctcgg ctcactgcaa cctccacctc ccgggctcaa gccattctcc tgcctcagcc     4800

tcccaagcag ctgggattac aggcacccgc caccacgccc agctaatttt tttgtatttt     4860

gagtagagac cgggtttcac catattggcc agtctcgtct ggaactcctg acctcagatg     4920

atccgcccgc ctcagcctcc caaagtgctg ggattacagg catgagccac cacgcccagc     4980

gtccaaccca ctgttggatg aaacttgctg cacgtcatac attttgctgt tggcaaacaa     5040

gtctgaatgt tgatttgaag tttggtagtt tattactatc tattggcagc aaagactgtt     5100

tattggtata ctacaatatg atttaacttt tattttgggg ataaatagta gaaaaaagtg     5160

aaacagaatg aaggcaggtg ttttttattc taatgatgga ataatacaga gatactggac     5220

gatctctagc agttaattat tgtgacccat ataaaattat acaggtcaca gtataattct     5280

ctattaccgt ttttacacca gtaagtctta gataaactaa gcatgcttat gaattatgta     5340

tacagttaga atgcattatt tttacagagg aacaattgct tgtatgtact aacactgttc     5400

tcttggcttg cctcaagttc tactcattat tttatataaa atactattag gctgggcacg     5460

gtggctcacg cctataatcc cagcactttg ggaggtggag gctggcggat tacttgaagc     5520

caggagttcg agaccagcct ggccaaaatg gtgaaacccc atctctataa aaatacaaaa     5580

attagccagg tgtcatgata catgcctgta atcccagctt cttgggaggc tgaggcacgg     5640

gaatcgcttg aacccgggaa gcacaggttg cagtgagcca agatcatgcc actgcacccc     5700

cagcctgggt gacagagtgc aacactgtct cacaaaacaa aacaaaaaca tcagattctg     5760

tttgtgatgc ctagttgctt acaacctaaa cagtgcaatg ccttaaggaa atgaaaagga     5820

gccataagta gtcatttata tttttatttt gaagtgtgct ttttctaaac tcccagattg     5880

acatgatgga ctgtaagtta gtttctctgt ttctgtcttt gtgcctgtag agtgtacttg     5940

gcacttacaa attcccagta tccagaaaga tgatctgatg aaatcaaatt ggatggatct     6000

tggcagactg tgacactcaa ttacagcctt cactttcagt caaaaacgga cacttggcaa     6060

ggaggtgcct ggttgtttca ctaaatgtca cttgtgtgtg taatatttta aagctttttc     6120

cccacaggaa attcgggtca taaaatcctg aaaaataatt ctaggtggga aaagcatttt     6180

aggaaatgag agatgtggtg ctgcttttct tctctcagag tgctttctca gcaggacact     6240

agccctgcct ttaagatggg gaagttgggg catgtgcctc tgctcttact gtctgcagct     6300

ctgaaggtag gtgctgtccc actcggacaa tcgcccaagc agcagtgacc atagttctct     6360

tctatgcaag tccccaggag aaggtaaact gtgtggaatg gggatgtgtt ctggttgctg     6420

ctgaatcccc tcttcttacc acagtgcctg gcacgttgca cacactcaaa tacgtaataa     6480

tgaacattta ttgaaagcag cagttgaagc tgaccaattt ctggtacctt gtcatgtaaa     6540

ttttagatgg taaggcgcag atgttacttt ttttgctttt tttcttcagc acttgatgaa     6600

atttcccaaa catgcagaaa tgttgaaaga cttgtatagt gaacatctac gacctagaat     6660

ctgcagtaat attatgttac atttgcttta tcacttgata gatgttactt ttaatgagac     6720

ttcaagtttg gtttctctaa acaaaatatt ctaaaataac tgaacaactt taatcaattt     6780

gtcttaagtt ctttggggga acttgggaca tttgctttgt aactggaatt gcagccctca     6840

cgttaagcta attttaaact ttgcaaattt gttatgctga atttcagtct tatttatttt     6900

gcctgaaggg gtattttttg taatggattt atttgaaggt ccttgataaa ttgtgcagaa     6960

tattctcgtg ttctttttgc acttgataaa ttatctaatt tctgtggtga gaatgtaatt     7020

tggggcctat tttgtttata caagcttcca gaattatgtt ctcagaggga tgaaaaggtg     7080

taatttagca tataggtcac taaattagga gctaagacac attttctcct gactgaccat     7140

gggtcaatca gttttgtctt cgtgtccttt tccttgtaaa gtagaaacta gaatttgaaa     7200

tttaaatatt aaataatggg taacattcat taatgtatga ctctattaag aaagacactg     7260

tgaatccagg gaggattctc ataattctgt aaactgtatg acaagctgtg gaatgaaatc     7320

tgacttttga aaattgaaag acatccagtg gtcttatcac aaagcctgct tttcctcaga     7380

acttaactat tgccatggaa tttgtaagca gttatcctaa tccatctgga ctctgaaaat     7440

gcatccttta tgagagggag tgaatgcaaa gataagggtg gggaaacact aatcatgaaa     7500

agaatgaaaa tcagtgttca gttttaagag caggttgtat tgaaggaagg gattaaagga     7560

attatccaga tttgaggtgg cacatcttcc accactccct gcaccatcag catgcacgga     7620

gcgcataaaa caagccctgc tcctaatggc agtgaaacct cggatggcct ccatcaggtc     7680

aatacaactg aattgctggg ctgacttaag attgaaggac tccattttag taagtagaga     7740

agtgtgacct ttctcaaccc aggttgtgaa tgtggattca cacttatctc aaaaaggcac     7800

ctggagtttt aactttatgt catgtctcag tactggttgc aaggtatgac caaaagtgtt     7860

ccttgaatgg cacctttttg aatattaatt tagaagaaaa catgccagac tgacatactt     7920

accccctccg cactgttact acttccttac cagccctatg tactgcatca atgtctacaa     7980

gaaagcactc ttcattaaaa tgaaatatat atattaaaat aaaaaaaaaa aaaaaaaaaa     8040


<210>  53
<211>  7947
<212>  DNA
<213>  Homo sapiens

<400>  53
ctcctccccg gcgcgctccc tgcccctcgc tccccgcagc cagcagagaa ggcggaagca       60

gtggcgtccg cagctggggc ttggcctgcg ggcggccagc gaaggtggcg aaggctccca      120

ctggatccag agtttgccgt ccaagcagcc tcgtctcggc gcgcagtgtc tgtgtccgtc      180

ctctaccagc gccttggctg agcggagtcg tgcggttggt gggggagccc tgccctcctg      240

gttcggcctc cccgcgcact agaacgagca agtgataatc aagttactat gagtctgcta      300

aactgtgaaa acagctgtgg atccagccag tctgaaagtg actgctgtgt ggccatggcc      360

agctcctgta gcgctgtaac aaaagatgat agtgtgggtg gaactgccag cacggggaac      420

ctctccagct catttatgga ggagatccag ggatatgatg tagagtttga cccacccctg      480

gaaagcaagt atgaatgccc catctgcttg atggcattac gagaagcagt gcaaacgcca      540

tgcggccata ggttctgcaa agcctgcatc ataaaatcaa taagggatgc aggtcacaaa      600

tgtccagttg acaatgaaat actgctggaa aatcaactat ttccagacaa ttttgcaaaa      660

cgtgagattc tttctctgat ggtgaaatgt ccaaatgaag gttgtttgca caagatggaa      720

ctgagacatc ttgaggatca tcaagcacat tgtgagtttg ctcttatgga ttgtccccaa      780

tgccagcgtc ccttccaaaa attccatatt aatattcaca ttctgaagga ttgtccaagg      840

agacaggttt cttgtgacaa ctgtgctgca tcaatggcat ttgaagataa agagatccat      900

gaccagaact gtcctttggc aaatgtcatc tgtgaatact gcaatactat actcatcaga      960

gaacagatgc ctaatcatta tgatctagac tgccctacag ccccaattcc atgcacattc     1020

agtacttttg gttgccatga aaagatgcag aggaatcact tggcacgcca cctacaagag     1080

aacacccagt cacacatgag aatgttggcc caggctgttc atagtttgag cgttataccc     1140

gactctgggt atatctcaga ggtccggaat ttccaggaaa ctattcacca gttagagggt     1200

cgccttgtaa gacaagacca tcaaatccgg gagctgactg ctaaaatgga aactcagagt     1260

atgtatgtaa gtgagctcaa acgaaccatt cgaacccttg aggacaaagt tgctgaaatc     1320

gaagcacagc agtgcaatgg aatttatatt tggaagattg gcaactttgg aatgcatttg     1380

aaatgtcaag aagaggagaa acctgttgtg attcatagcc ctggattcta cactggcaaa     1440

cccgggtaca aactgtgcat gcgcttgcac cttcagttac cgactgctca gcgctgtgca     1500

aactatatat ccctttttgt ccacacaatg caaggagaat atgacagcca cctcccttgg     1560

cccttccagg gtacaatacg ccttacaatt cttgatcagt ctgaagcacc tgtaaggcaa     1620

aaccacgaag agataatgga tgccaaacca gagctgcttg ctttccagcg acccacaatc     1680

ccacggaacc caaaaggttt tggctatgta acttttatgc atctggaagc cctaagacaa     1740

agaactttca ttaaggatga cacattatta gtgcgctgtg aggtctccac ccgctttgac     1800

atgggtagcc ttcggaggga gggttttcag ccacgaagta ctgatgcagg ggtatagctt     1860

gccctcactt gctcaaaaac aactacctgg agaaaacagt gcctttcctt gccctgttct     1920

caataacatg caaacaaaca agccacggga aatatgtaat atctactagt gagtgttgtt     1980

agagaggtca cttactattt cttcctgtta caaatgatct gaggcagttt tttcctggga     2040

atccacacgt tccatgcttt ttcagaaatg ttaggcctga agtgcctgtg gcatgttgca     2100

gcagctattt tgccagttag tatacctctt tgttgtactt tcttgggctt ttgctctggt     2160

gtattttatt gtcagaaagt ccagactcaa gagtactaaa cttttaataa taatggattt     2220

tccttaaaac ttcagtcttt ttgtagtatt atatgtaata tattaaaagt gaaaatcact     2280

accgccttgt gctagtgccc tcgagaagag ttattgctct agaaagttga gttctcattt     2340

ttttaacctg ttatagattt cagaggattt gaaccataat ccttggaaaa cttaagttct     2400

cattcacccc agtttttcct ccaggttgtt actaaggata ttcagggatg agtttaaacc     2460

ctaaatataa ccttaattat ttagtgtaaa catgtctgtt gaataatact tgtttaagtg     2520

ttccttctgc cttgcttact tatttccttg aggttacgaa gtagcatctt ccccagagtt     2580

tataatgctg agaaccacgt ggataccaac tgctcattgt tatgctatgt aacccttttt     2640

gtctattcag tgcagagtga atttcacagc tctgcatatg tcttcatttg tttaatgctt     2700

acaagacagg agatgcacac atacaatcag caacataaaa attaaaagtg acccaagtag     2760

tcagcgcatg tggcatctca ttggtggtga cagaagctat gtgagccaga agttttcagc     2820

tcttttgaat accctctggt ttatttcgat taaaaagaac aaaattgatt tcctaaaatc     2880

agaatttttt aaaacttggg agatgattgg agatacctag gaggtcacca aactaggatt     2940

agaagtcaca gtggttgtat cacaacttag cttgagtatg ttgctgtagc ctaacaactg     3000

caggttctga gaaggatcct gtagaatcct ggaagtaacc agattttcct aatagggaga     3060

tgattttttt gtgtgccatc atgtatttgt taaaggccta tatatagata taaaatatcg     3120

tggaatctag ttctcaggga gacccgcaac tagtataagc ttataaagga tctaaagatc     3180

catccaccat ttaaagttgt ctggtaatga gagatgacat tgtatccccc agagaggcca     3240

aatcagagtc gccagccagc gttctagatc agccttaatt tcaagagaaa gccaaggacc     3300

tcatctgcag gggagtgtgg ttttcagccc cagcgagtgt cactttgaac tttccctttg     3360

cttttttctc tcttctccct ccccacccac ccttaggctc ctgatctggt gagtttgtta     3420

tggagtgaaa ataaaagtca agcagagacc ttgtttcccg tgccaccatt agtaccacaa     3480

gctcatggct agttaccaca ttacttcctg gcagtttgtg tccctcagct gtgccttcca     3540

accagcgcct gagaatcact gcataccacc ctctaggtag ggaaacctac actgctgctg     3600

ttcctgtgat tattttacaa tgaataaata attgtcaagt tccatttaaa aactgaacag     3660

tagtattttt gtatttgcgt agaaaaagcc tgaaggaaat atactaaact ttttgttggc     3720

ttattttcct ttgcgcttgc ttatattttt tacattttct acaataaatg tgtactttta     3780

tcggagaaaa aaattaaatg ttgccacaaa acatttaatc tccacgcccc cagctcaaaa     3840

aaggaaatga tatttaaaag cttcctggtc agatttctat taaaagcact ggctgtgcat     3900

tagatacaaa gaggagtcat ttcctgcctt ggtgatacta tttttttcta ctaactcaag     3960

agtctttatt aaaaaaaaaa gttgttttgc ctaatttcag cttttagcaa gcttcccatc     4020

tgtaaaatga tttggaccag atatttctag agtcccctcc agccataaca ttctgtctca     4080

aattaagttc caaccagcag aacaatgaca atacttagga aagtattttg ccagtataaa     4140

atgtctttaa cttactcttt gctgacactg atactttcct ctaatttagt gtctatcagc     4200

tgggtcacat cttaagtaaa atgagcaatt ttaaccccca acatttggca ttttgtcata     4260

aaccagccag ttattttatg ctggtcattc atcttgacta caaagtagaa tagtcaagct     4320

gtcattccaa atagaaaact ttttacttca atcagaatta agccttaacc tggaaagttg     4380

gtttcttcct tacattttcc caatctccta ctctattctt aaacatgcta gtttcactca     4440

gttgggtata caagcctttg ggctttatgt tgtatgttac taaccacctt ttaccatatt     4500

tatcttttgg catcattctg ggacattgct aaattaaaaa agaaattgtt tccacttttt     4560

tctggagatg ttcaactaaa ggttgttttg ttttgttttt tgttttgaga cagtctcacc     4620

ctgacgctca ggctggagtg cagtggtgca acctcggctc actgcaacct ccacctcccg     4680

ggctcaagcc attctcctgc ctcagcctcc caagcagctg ggattacagg cacccgccac     4740

cacgcccagc taattttttt gtattttgag tagagaccgg gtttcaccat attggccagt     4800

ctcgtctgga actcctgacc tcagatgatc cgcccgcctc agcctcccaa agtgctggga     4860

ttacaggcat gagccaccac gcccagcgtc caacccactg ttggatgaaa cttgctgcac     4920

gtcatacatt ttgctgttgg caaacaagtc tgaatgttga tttgaagttt ggtagtttat     4980

tactatctat tggcagcaaa gactgtttat tggtatacta caatatgatt taacttttat     5040

tttggggata aatagtagaa aaaagtgaaa cagaatgaag gcaggtgttt tttattctaa     5100

tgatggaata atacagagat actggacgat ctctagcagt taattattgt gacccatata     5160

aaattataca ggtcacagta taattctcta ttaccgtttt tacaccagta agtcttagat     5220

aaactaagca tgcttatgaa ttatgtatac agttagaatg cattattttt acagaggaac     5280

aattgcttgt atgtactaac actgttctct tggcttgcct caagttctac tcattatttt     5340

atataaaata ctattaggct gggcacggtg gctcacgcct ataatcccag cactttggga     5400

ggtggaggct ggcggattac ttgaagccag gagttcgaga ccagcctggc caaaatggtg     5460

aaaccccatc tctataaaaa tacaaaaatt agccaggtgt catgatacat gcctgtaatc     5520

ccagcttctt gggaggctga ggcacgggaa tcgcttgaac ccgggaagca caggttgcag     5580

tgagccaaga tcatgccact gcacccccag cctgggtgac agagtgcaac actgtctcac     5640

aaaacaaaac aaaaacatca gattctgttt gtgatgccta gttgcttaca acctaaacag     5700

tgcaatgcct taaggaaatg aaaaggagcc ataagtagtc atttatattt ttattttgaa     5760

gtgtgctttt tctaaactcc cagattgaca tgatggactg taagttagtt tctctgtttc     5820

tgtctttgtg cctgtagagt gtacttggca cttacaaatt cccagtatcc agaaagatga     5880

tctgatgaaa tcaaattgga tggatcttgg cagactgtga cactcaatta cagccttcac     5940

tttcagtcaa aaacggacac ttggcaagga ggtgcctggt tgtttcacta aatgtcactt     6000

gtgtgtgtaa tattttaaag ctttttcccc acaggaaatt cgggtcataa aatcctgaaa     6060

aataattcta ggtgggaaaa gcattttagg aaatgagaga tgtggtgctg cttttcttct     6120

ctcagagtgc tttctcagca ggacactagc cctgccttta agatggggaa gttggggcat     6180

gtgcctctgc tcttactgtc tgcagctctg aaggtaggtg ctgtcccact cggacaatcg     6240

cccaagcagc agtgaccata gttctcttct atgcaagtcc ccaggagaag gtaaactgtg     6300

tggaatgggg atgtgttctg gttgctgctg aatcccctct tcttaccaca gtgcctggca     6360

cgttgcacac actcaaatac gtaataatga acatttattg aaagcagcag ttgaagctga     6420

ccaatttctg gtaccttgtc atgtaaattt tagatggtaa ggcgcagatg ttactttttt     6480

tgcttttttt cttcagcact tgatgaaatt tcccaaacat gcagaaatgt tgaaagactt     6540

gtatagtgaa catctacgac ctagaatctg cagtaatatt atgttacatt tgctttatca     6600

cttgatagat gttactttta atgagacttc aagtttggtt tctctaaaca aaatattcta     6660

aaataactga acaactttaa tcaatttgtc ttaagttctt tgggggaact tgggacattt     6720

gctttgtaac tggaattgca gccctcacgt taagctaatt ttaaactttg caaatttgtt     6780

atgctgaatt tcagtcttat ttattttgcc tgaaggggta ttttttgtaa tggatttatt     6840

tgaaggtcct tgataaattg tgcagaatat tctcgtgttc tttttgcact tgataaatta     6900

tctaatttct gtggtgagaa tgtaatttgg ggcctatttt gtttatacaa gcttccagaa     6960

ttatgttctc agagggatga aaaggtgtaa tttagcatat aggtcactaa attaggagct     7020

aagacacatt ttctcctgac tgaccatggg tcaatcagtt ttgtcttcgt gtccttttcc     7080

ttgtaaagta gaaactagaa tttgaaattt aaatattaaa taatgggtaa cattcattaa     7140

tgtatgactc tattaagaaa gacactgtga atccagggag gattctcata attctgtaaa     7200

ctgtatgaca agctgtggaa tgaaatctga cttttgaaaa ttgaaagaca tccagtggtc     7260

ttatcacaaa gcctgctttt cctcagaact taactattgc catggaattt gtaagcagtt     7320

atcctaatcc atctggactc tgaaaatgca tcctttatga gagggagtga atgcaaagat     7380

aagggtgggg aaacactaat catgaaaaga atgaaaatca gtgttcagtt ttaagagcag     7440

gttgtattga aggaagggat taaaggaatt atccagattt gaggtggcac atcttccacc     7500

actccctgca ccatcagcat gcacggagcg cataaaacaa gccctgctcc taatggcagt     7560

gaaacctcgg atggcctcca tcaggtcaat acaactgaat tgctgggctg acttaagatt     7620

gaaggactcc attttagtaa gtagagaagt gtgacctttc tcaacccagg ttgtgaatgt     7680

ggattcacac ttatctcaaa aaggcacctg gagttttaac tttatgtcat gtctcagtac     7740

tggttgcaag gtatgaccaa aagtgttcct tgaatggcac ctttttgaat attaatttag     7800

aagaaaacat gccagactga catacttacc ccctccgcac tgttactact tccttaccag     7860

ccctatgtac tgcatcaatg tctacaagaa agcactcttc attaaaatga aatatatata     7920

ttaaaataaa aaaaaaaaaa aaaaaaa                                         7947


<210>  54
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr 
        275                 280                 285             


Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His Gln Leu Glu Gly 
    290                 295                 300                 


Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu Thr Ala Lys Met 
305                 310                 315                 320 


Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg Thr Ile Arg Thr 
                325                 330                 335     


Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile 
            340                 345                 350         


Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu Lys Cys Gln Glu 
        355                 360                 365             


Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe Tyr Thr Gly Lys 
    370                 375                 380                 


Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln Leu Pro Thr Ala 
385                 390                 395                 400 


Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His Thr Met Gln Gly 
                405                 410                 415     


Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu 
            420                 425                 430         


Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln Asn His Glu Glu 
        435                 440                 445             


Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile 
    450                 455                 460                 


Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe Met His Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr Leu Leu Val Arg 
                485                 490                 495     


Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu Arg Arg Glu Gly 
            500                 505                 510         


Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
        515                 520         


<210>  55
<211>  6188
<212>  DNA
<213>  Mus musculus

<400>  55
tagcgagctg agaaggcgga agcagcggcg gccgcggctg gggctgaggc tccggccgtc       60

ggcggacgca gcagccgcgg cccacgagcc gggagtttgg cgtcggagcc acttggtctc      120

ggagtgccgt gtatgtaggc gacgcggcgc agcccgggga agccttccca gttggttgtg      180

aagtctcagc gtgtacgatc gggttgtgtg tgtctgtgta tgcctcatga gtgtagccca      240

cgaaagccag aagaaggtgt cagatccctt ggagctgaag ggatagttgg taataagcct      300

tctgacgtgg atgctggcac ggaaacttgg gtcttctgga agaactacag ttgttcttag      360

ctgctggggt gtctctgcag ctcccaagga gggatcctga gcagatcgac tgacaacaga      420

gctactatga gtctcttaaa ctgtgagaac agctgcgggt ccagccagtc gtccagtgac      480

tgctgcgctg ccatggccgc ctcctgcagc gctgcagtga aagatgacag cgtgagtggc      540

tctgccagca ccgggaacct ctccagctcc ttcatggagg agatccaggg ctacgatgtg      600

gagtttgacc cacctctgga gagcaagtat gagtgtccca tctgcttgat ggctttacgg      660

gaagcagtgc aaacaccatg tggccacagg ttctgcaaag cctgcatcat caaatccata      720

agggatgcag ggcacaagtg cccagttgac aatgaaatac tgctggaaaa tcaactgttt      780

cccgacaatt ttgcaaagcg agagattctt tccctgacgg taaagtgccc aaataaaggc      840

tgtttgcaaa agatggaact gagacatctc gaggatcatc aagtacattg tgaatttgct      900

ctagtgaatt gtccccagtg ccaacgtcct ttccagaagt gccaggttaa tacacacatt      960

attgaggatt gtcccaggag gcaggtttct tgtgtaaact gtgctgtgtc catggcatat     1020

gaagagaaag agatccatga tcaaagctgt cctctggcaa atatcatctg tgaatactgt     1080

ggtacaatcc tcatcagaga acagatgcct aatcattatg atctggactg cccaacagct     1140

ccaatccctt gcacattcag tgtttttggc tgtcatgaaa agatgcagag gaatcacttg     1200

gcacgacact tgcaagagaa tacccagttg cacatgagac tgttggccca ggctgttcat     1260

aatgttaacc ttgctttgcg tccgtgcgat gccgcctctc catcccgggg atgtcgtcca     1320

gaggacccaa attatgagga aactatcaaa cagttggaga gtcgcctagt aagacaggac     1380

catcagatcc gggagctgac tgccaaaatg gaaactcaga gtatgtacgt gggcgagctc     1440

aaacggacca ttcggaccct ggaggacaag gttgccgaaa tggaagcaca gcagtgtaac     1500

gggatctaca tttggaagat tggcaacttt gggatgcact tgaaatccca agaagaggaa     1560

agacctgttg tcatccatag ccctggattc tacacaggca gacctgggta caagctgtgc     1620

atgcgcctgc atcttcagtt accgacagct cagcgctgtg caaactatat atcccttttt     1680

gtccacacaa tgcaaggaga atatgacagc cacctcccct ggcccttcca gggtacaata     1740

cgccttacaa ttctcgacca gtctgaagca cttataaggc aaaaccacga agaggtcatg     1800

gacgccaaac cagaactgct tgcctttcag cgacccacaa tcccacggaa ccccaaaggt     1860

tttggctatg taacatttat gcacctggaa gccttaagac agggaacctt cattaaggat     1920

gatacattac tagtgcgctg tgaagtctct acccgctttg acatgggtgg ccttcggaag     1980

gagggtttcc agccacgaag tactgatgcg ggggtgtagc gtccatgtac ttgtgttcaa     2040

aaactaggaa ccatatggga aaaccgtgcc ttccatgcct ggccccagta aacaatgttc     2100

aaacaagcag tgggagaggt gtaaggccta gcagcagatg tcatcagtga ggtcacgagc     2160

cacttcttac tgttaacaaa tacctgaggc agttcccatg ggaacctaca tgtcccctgt     2220

atcttcaaaa cgtcaacatt tgaagggcct gtggctcatc tgtctgtcag ggtacccctt     2280

cactgtgctt ccatgggcta ttttgtccgt gtactttact gtaaaaaagg ccagacttag     2340

cgtgctgcag ctcaatcgtt taataagacc ggtgccttaa aaacttgagg ggtttttagg     2400

acactgatta ctatattaaa catgaaaatc accactgcct gtgctggtgc cagtagagaa     2460

gttaccgctc tggtgttgag ttctcattta gttgactcct gtgaatttca gaggctttga     2520

accatgatcc ctggaaggct taagttctca agtactccct cctctatagt tcactaagga     2580

tccagggact ggtttaaccc ttacttagtg tgaatgtatt gtccactgaa caccaagcat     2640

cccccactac tttcctgttt tgaaatatgc tccaggcggc ctcttcccag tctgtaagac     2700

cgcggtcatg tgcttgccaa ctgctgagtg ttactgccat ggaacctttc ttgtctgtcc     2760

cgtgcagctt ggtttccaca gccggttgca tatcttctgt tgcttgcaaa cacaaaatca     2820

ccagcccaaa cgagtgattt agctcactag ccattaaatg gcatctcgtg gatgatgaca     2880

gcaactctta cagccaggaa acttcagccc ctcttaacta gcttttgatt tagcttataa     2940

ggttaattga aataaaattg atttttctca aggggttgga gaattggctc agtggttaag     3000

agccttggct gctcttccag aggatcccca gtctgtaact ccagttccag ggcatctgac     3060

accctcatac agacactcat gcaggcaaaa caccagtgca cataaaatta aacaaacaaa     3120

taaataaata aattgatttc ctcaaaacag aatttattgg aacttgggaa attgtaggta     3180

cctgagagat gcctaaacca aggttggcta tcacggttgt gtggacactc agcttgagtg     3240

gtggctttgt ccagctcagt agaggttctg atctgtgacc ctaatgtgga gaggtgactg     3300

tcgtgctgct gtgtatttgt taatgtcctg tacatataca gtactttgga gtctagttct     3360

cagggagccc tacgactagt tagagccttt gtaaggaagc agaggggatc ctctcctgct     3420

gtttacacaa gatcagctat gtgttctggt ggtaagaaag gcatccgtgc cttcagctga     3480

atcagagacc cgagcagtgc tctgacctgc cctgttccca gagaacgctc agagcctcca     3540

ccaaggagtc tgtttctcag ctgtagccag ccagggccac tttgacctct tcattttccc     3600

ctgcttccat ccttccccta taaaggtgag gggaagacct tgtcccctac cattatcaca     3660

agctcatcac aggtctcttc tgttggatcc aggaaatgtg tgtcccttag ctgtgcctcc     3720

agcagccctg agctgcttgt agcaacttct gcctaaggag cactgcatgg tcttatactg     3780

tagttgtttc ccagtggagt aataaatgtg ggcttgtttg ttgtttcttt aaagcaagca     3840

gtagctgtgt ctatatttat ttagaaattg cctgaagaag attactcaac tatttgaaga     3900

cttattttct atatgccttt cttaattttt ttatgttata tgtcaccaca aaaatatgaa     3960

ctccccaacc ccctctccgt tttttgaaaa aggaaatgac atttaagaac ttcctcatca     4020

gatttctctt tttaaaatat ctgtattagg aagagcagtc gtttcctgcc gtggttttga     4080

ctttttttaa aaaaaactct aacatctttt aaagtttttt tgcataagtt aaactgttcc     4140

cagctttaaa ttgtcctccc tatagggcaa gttggactag gtgtttctag tatccgcatt     4200

gagaagccca gtgctgagcc acaatactca ctaaaaggct ttccccgtag aggtgtgact     4260

gcccctaact gctaacacgg atggttcact gcagtgtaat gtccatccgc tagaatacac     4320

ctcaggtagt tttagaactt gcagcatttg gtgtttgtaa taagccaacc agttacttta     4380

tgttactcaa ttgccacgaa tgcagagtaa aactaatcaa gctgacattc aaggtcaaca     4440

cttagtaagg tcaactcagg atcaagtctt agcctagaaa gccgctttct ttacttcacc     4500

actttctgaa cattctcttt gtaccaatgg gcctataaga atccgtatag tccagagtgc     4560

attggccatc tttccttacc aatctagaac actgctgaat ttaaagttgt ttcttcttag     4620

aaaaatgcct accttactat tgaagatttt tccccaagtc atatatttcc ctcttagaaa     4680

tcaggccaga cggcagttct agtttggaag ttggttacag tcctttggct gttaccatct     4740

ctagccattc tgctttcttc tggagaatga agaggagaaa agtgcattaa agtacaaaag     4800

gtgtcctctc accctcggaa gatcaactga caggtgttgg atgatctcca acaagtaaat     4860

tttgtgacca gtataaagtt gaatttgtac caatatcaaa caaagtctga ccaatgtaaa     4920

ttatgtgcac aattagaata tcttctcctt aaggagaggt tgcttgtttc tgctttacct     4980

ggagtttcct tctttcgcat gtgactggaa aacgttttaa ctttaactat cgaggtgatt     5040

cttacttaag actttgaagt gcttttctct ctttttctgt cgttaacaca catcttttct     5100

tgacttgact caaattctcg ccattgttac agttttttat ggggtgtttg gtgattagtt     5160

tgctggctgc cttgagggag tgaacagggc acggtcaagc gtcgtttgat tgtctgttga     5220

aatactcttt aaatgtcggc attctcaggg taactgtcat ttgtttcaaa gttgatgtga     5280

ttgtctggga aatggatgga tgcttcccaa ttcccagaat ccagaaaaat gaaaccagat     5340

gtgatcaacc tgaacttggg acactctcgg tcacaagcgt tgaagtcact caaaaaggac     5400

taagctagtt atttctctgt gggtcctctg tgtctttgat gttttaaatt gctcagcccc     5460

gccccaataa ataaataaat aaataagaaa agaaaagagt tgtagttttt cacattgtgg     5520

aatgtggaga ggaactcctt ttcctgtcct gtgtctcctc agcggagccc agccctgcct     5580

gacacaggag aaaagggtgg cctgttggtc acctgccctt cagaatgtag ccccatctga     5640

ctcctaaaac cccagtttcc ttcagtgcag gctccaggag agggcagaga ccccattctg     5700

gtcactgctg aacccctgtt tttagcatac tgtgcatggg cctggccaat agtcacaagc     5760

tttaatggga gccagggcag aagctgactg gctgctgggt agcctacttg tcatgtaagt     5820

cagttggtaa agtgagagtg ttcttttttc tgcttttctc ccgggacttt gctactgcag     5880

ttctcaaaca tggaagtgag tttaagacct agtgaacacc tcccacctag gatctgcagt     5940

gacattgggt gtgctctgat ttaatgcttc tatcatgtaa attctaattt ctccttaagg     6000

ctgttcaatc ctgaaataat taaacaactt gaagttgtat aaaattctcc ttggaaactt     6060

gtgatatttt attgtaattt atcttgtagc ttctgcttta tgccaactta aaatttgtgg     6120

aaatgttgtg aggaacttta ctcttatgtc tttgtctaca ggagtatttt tataaaggat     6180

ttatttgc                                                              6188


<210>  56
<211>  5985
<212>  DNA
<213>  Mus musculus

<400>  56
tagcgagctg agaaggcgga agcagcggcg gccgcggctg gggctgaggc tccggccgtc       60

ggcggacgca gcagccgcgg cccacgagcc gggagtttgg cgtcggagcc acttggtctc      120

ggagtgccgt gtatgtaggc gacgcggcgc agcccgggga agccttccca gttggttgtg      180

aagtctcagc gtgtacgatc gatcgactga caacagagct actatgagtc tcttaaactg      240

tgagaacagc tgcgggtcca gccagtcgtc cagtgactgc tgcgctgcca tggccgcctc      300

ctgcagcgct gcagtgaaag atgacagcgt gagtggctct gccagcaccg ggaacctctc      360

cagctccttc atggaggaga tccagggcta cgatgtggag tttgacccac ctctggagag      420

caagtatgag tgtcccatct gcttgatggc tttacgggaa gcagtgcaaa caccatgtgg      480

ccacaggttc tgcaaagcct gcatcatcaa atccataagg gatgcagggc acaagtgccc      540

agttgacaat gaaatactgc tggaaaatca actgtttccc gacaattttg caaagcgaga      600

gattctttcc ctgacggtaa agtgcccaaa taaaggctgt ttgcaaaaga tggaactgag      660

acatctcgag gatcatcaag tacattgtga atttgctcta gtgaattgtc cccagtgcca      720

acgtcctttc cagaagtgcc aggttaatac acacattatt gaggattgtc ccaggaggca      780

ggtttcttgt gtaaactgtg ctgtgtccat ggcatatgaa gagaaagaga tccatgatca      840

aagctgtcct ctggcaaata tcatctgtga atactgtggt acaatcctca tcagagaaca      900

gatgcctaat cattatgatc tggactgccc aacagctcca atcccttgca cattcagtgt      960

ttttggctgt catgaaaaga tgcagaggaa tcacttggca cgacacttgc aagagaatac     1020

ccagttgcac atgagactgt tggcccaggc tgttcataat gttaaccttg ctttgcgtcc     1080

gtgcgatgcc gcctctccat cccggggatg tcgtccagag gacccaaatt atgaggaaac     1140

tatcaaacag ttggagagtc gcctagtaag acaggaccat cagatccggg agctgactgc     1200

caaaatggaa actcagagta tgtacgtggg cgagctcaaa cggaccattc ggaccctgga     1260

ggacaaggtt gccgaaatgg aagcacagca gtgtaacggg atctacattt ggaagattgg     1320

caactttggg atgcacttga aatcccaaga agaggaaaga cctgttgtca tccatagccc     1380

tggattctac acaggcagac ctgggtacaa gctgtgcatg cgcctgcatc ttcagttacc     1440

gacagctcag cgctgtgcaa actatatatc cctttttgtc cacacaatgc aaggagaata     1500

tgacagccac ctcccctggc ccttccaggg tacaatacgc cttacaattc tcgaccagtc     1560

tgaagcactt ataaggcaaa accacgaaga ggtcatggac gccaaaccag aactgcttgc     1620

ctttcagcga cccacaatcc cacggaaccc caaaggtttt ggctatgtaa catttatgca     1680

cctggaagcc ttaagacagg gaaccttcat taaggatgat acattactag tgcgctgtga     1740

agtctctacc cgctttgaca tgggtggcct tcggaaggag ggtttccagc cacgaagtac     1800

tgatgcgggg gtgtagcgtc catgtacttg tgttcaaaaa ctaggaacca tatgggaaaa     1860

ccgtgccttc catgcctggc cccagtaaac aatgttcaaa caagcagtgg gagaggtgta     1920

aggcctagca gcagatgtca tcagtgaggt cacgagccac ttcttactgt taacaaatac     1980

ctgaggcagt tcccatggga acctacatgt cccctgtatc ttcaaaacgt caacatttga     2040

agggcctgtg gctcatctgt ctgtcagggt accccttcac tgtgcttcca tgggctattt     2100

tgtccgtgta ctttactgta aaaaaggcca gacttagcgt gctgcagctc aatcgtttaa     2160

taagaccggt gccttaaaaa cttgaggggt ttttaggaca ctgattacta tattaaacat     2220

gaaaatcacc actgcctgtg ctggtgccag tagagaagtt accgctctgg tgttgagttc     2280

tcatttagtt gactcctgtg aatttcagag gctttgaacc atgatccctg gaaggcttaa     2340

gttctcaagt actccctcct ctatagttca ctaaggatcc agggactggt ttaaccctta     2400

cttagtgtga atgtattgtc cactgaacac caagcatccc ccactacttt cctgttttga     2460

aatatgctcc aggcggcctc ttcccagtct gtaagaccgc ggtcatgtgc ttgccaactg     2520

ctgagtgtta ctgccatgga acctttcttg tctgtcccgt gcagcttggt ttccacagcc     2580

ggttgcatat cttctgttgc ttgcaaacac aaaatcacca gcccaaacga gtgatttagc     2640

tcactagcca ttaaatggca tctcgtggat gatgacagca actcttacag ccaggaaact     2700

tcagcccctc ttaactagct tttgatttag cttataaggt taattgaaat aaaattgatt     2760

tttctcaagg ggttggagaa ttggctcagt ggttaagagc cttggctgct cttccagagg     2820

atccccagtc tgtaactcca gttccagggc atctgacacc ctcatacaga cactcatgca     2880

ggcaaaacac cagtgcacat aaaattaaac aaacaaataa ataaataaat tgatttcctc     2940

aaaacagaat ttattggaac ttgggaaatt gtaggtacct gagagatgcc taaaccaagg     3000

ttggctatca cggttgtgtg gacactcagc ttgagtggtg gctttgtcca gctcagtaga     3060

ggttctgatc tgtgacccta atgtggagag gtgactgtcg tgctgctgtg tatttgttaa     3120

tgtcctgtac atatacagta ctttggagtc tagttctcag ggagccctac gactagttag     3180

agcctttgta aggaagcaga ggggatcctc tcctgctgtt tacacaagat cagctatgtg     3240

ttctggtggt aagaaaggca tccgtgcctt cagctgaatc agagacccga gcagtgctct     3300

gacctgccct gttcccagag aacgctcaga gcctccacca aggagtctgt ttctcagctg     3360

tagccagcca gggccacttt gacctcttca ttttcccctg cttccatcct tcccctataa     3420

aggtgagggg aagaccttgt cccctaccat tatcacaagc tcatcacagg tctcttctgt     3480

tggatccagg aaatgtgtgt cccttagctg tgcctccagc agccctgagc tgcttgtagc     3540

aacttctgcc taaggagcac tgcatggtct tatactgtag ttgtttccca gtggagtaat     3600

aaatgtgggc ttgtttgttg tttctttaaa gcaagcagta gctgtgtcta tatttattta     3660

gaaattgcct gaagaagatt actcaactat ttgaagactt attttctata tgcctttctt     3720

aattttttta tgttatatgt caccacaaaa atatgaactc cccaaccccc tctccgtttt     3780

ttgaaaaagg aaatgacatt taagaacttc ctcatcagat ttctcttttt aaaatatctg     3840

tattaggaag agcagtcgtt tcctgccgtg gttttgactt tttttaaaaa aaactctaac     3900

atcttttaaa gtttttttgc ataagttaaa ctgttcccag ctttaaattg tcctccctat     3960

agggcaagtt ggactaggtg tttctagtat ccgcattgag aagcccagtg ctgagccaca     4020

atactcacta aaaggctttc cccgtagagg tgtgactgcc cctaactgct aacacggatg     4080

gttcactgca gtgtaatgtc catccgctag aatacacctc aggtagtttt agaacttgca     4140

gcatttggtg tttgtaataa gccaaccagt tactttatgt tactcaattg ccacgaatgc     4200

agagtaaaac taatcaagct gacattcaag gtcaacactt agtaaggtca actcaggatc     4260

aagtcttagc ctagaaagcc gctttcttta cttcaccact ttctgaacat tctctttgta     4320

ccaatgggcc tataagaatc cgtatagtcc agagtgcatt ggccatcttt ccttaccaat     4380

ctagaacact gctgaattta aagttgtttc ttcttagaaa aatgcctacc ttactattga     4440

agatttttcc ccaagtcata tatttccctc ttagaaatca ggccagacgg cagttctagt     4500

ttggaagttg gttacagtcc tttggctgtt accatctcta gccattctgc tttcttctgg     4560

agaatgaaga ggagaaaagt gcattaaagt acaaaaggtg tcctctcacc ctcggaagat     4620

caactgacag gtgttggatg atctccaaca agtaaatttt gtgaccagta taaagttgaa     4680

tttgtaccaa tatcaaacaa agtctgacca atgtaaatta tgtgcacaat tagaatatct     4740

tctccttaag gagaggttgc ttgtttctgc tttacctgga gtttccttct ttcgcatgtg     4800

actggaaaac gttttaactt taactatcga ggtgattctt acttaagact ttgaagtgct     4860

tttctctctt tttctgtcgt taacacacat cttttcttga cttgactcaa attctcgcca     4920

ttgttacagt tttttatggg gtgtttggtg attagtttgc tggctgcctt gagggagtga     4980

acagggcacg gtcaagcgtc gtttgattgt ctgttgaaat actctttaaa tgtcggcatt     5040

ctcagggtaa ctgtcatttg tttcaaagtt gatgtgattg tctgggaaat ggatggatgc     5100

ttcccaattc ccagaatcca gaaaaatgaa accagatgtg atcaacctga acttgggaca     5160

ctctcggtca caagcgttga agtcactcaa aaaggactaa gctagttatt tctctgtggg     5220

tcctctgtgt ctttgatgtt ttaaattgct cagccccgcc ccaataaata aataaataaa     5280

taagaaaaga aaagagttgt agtttttcac attgtggaat gtggagagga actccttttc     5340

ctgtcctgtg tctcctcagc ggagcccagc cctgcctgac acaggagaaa agggtggcct     5400

gttggtcacc tgcccttcag aatgtagccc catctgactc ctaaaacccc agtttccttc     5460

agtgcaggct ccaggagagg gcagagaccc cattctggtc actgctgaac ccctgttttt     5520

agcatactgt gcatgggcct ggccaatagt cacaagcttt aatgggagcc agggcagaag     5580

ctgactggct gctgggtagc ctacttgtca tgtaagtcag ttggtaaagt gagagtgttc     5640

ttttttctgc ttttctcccg ggactttgct actgcagttc tcaaacatgg aagtgagttt     5700

aagacctagt gaacacctcc cacctaggat ctgcagtgac attgggtgtg ctctgattta     5760

atgcttctat catgtaaatt ctaatttctc cttaaggctg ttcaatcctg aaataattaa     5820

acaacttgaa gttgtataaa attctccttg gaaacttgtg atattttatt gtaatttatc     5880

ttgtagcttc tgctttatgc caacttaaaa tttgtggaaa tgttgtgagg aactttactc     5940

ttatgtcttt gtctacagga gtatttttat aaaggattta tttgc                     5985


<210>  57
<211>  530
<212>  PRT
<213>  Mus musculus

<400>  57

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Ser 
1               5                   10                  15      


Ser Asp Cys Cys Ala Ala Met Ala Ala Ser Cys Ser Ala Ala Val Lys 
            20                  25                  30          


Asp Asp Ser Val Ser Gly Ser Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Thr Val Lys Cys Pro Asn Lys Gly Cys Leu Gln Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Val His Cys Glu Phe Ala Leu Val 
145                 150                 155                 160 


Asn Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Cys Gln Val Asn Thr 
                165                 170                 175     


His Ile Ile Glu Asp Cys Pro Arg Arg Gln Val Ser Cys Val Asn Cys 
            180                 185                 190         


Ala Val Ser Met Ala Tyr Glu Glu Lys Glu Ile His Asp Gln Ser Cys 
        195                 200                 205             


Pro Leu Ala Asn Ile Ile Cys Glu Tyr Cys Gly Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Val Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Leu His Met Arg Leu 
            260                 265                 270         


Leu Ala Gln Ala Val His Asn Val Asn Leu Ala Leu Arg Pro Cys Asp 
        275                 280                 285             


Ala Ala Ser Pro Ser Arg Gly Cys Arg Pro Glu Asp Pro Asn Tyr Glu 
    290                 295                 300                 


Glu Thr Ile Lys Gln Leu Glu Ser Arg Leu Val Arg Gln Asp His Gln 
305                 310                 315                 320 


Ile Arg Glu Leu Thr Ala Lys Met Glu Thr Gln Ser Met Tyr Val Gly 
                325                 330                 335     


Glu Leu Lys Arg Thr Ile Arg Thr Leu Glu Asp Lys Val Ala Glu Met 
            340                 345                 350         


Glu Ala Gln Gln Cys Asn Gly Ile Tyr Ile Trp Lys Ile Gly Asn Phe 
        355                 360                 365             


Gly Met His Leu Lys Ser Gln Glu Glu Glu Arg Pro Val Val Ile His 
    370                 375                 380                 


Ser Pro Gly Phe Tyr Thr Gly Arg Pro Gly Tyr Lys Leu Cys Met Arg 
385                 390                 395                 400 


Leu His Leu Gln Leu Pro Thr Ala Gln Arg Cys Ala Asn Tyr Ile Ser 
                405                 410                 415     


Leu Phe Val His Thr Met Gln Gly Glu Tyr Asp Ser His Leu Pro Trp 
            420                 425                 430         


Pro Phe Gln Gly Thr Ile Arg Leu Thr Ile Leu Asp Gln Ser Glu Ala 
        435                 440                 445             


Leu Ile Arg Gln Asn His Glu Glu Val Met Asp Ala Lys Pro Glu Leu 
    450                 455                 460                 


Leu Ala Phe Gln Arg Pro Thr Ile Pro Arg Asn Pro Lys Gly Phe Gly 
465                 470                 475                 480 


Tyr Val Thr Phe Met His Leu Glu Ala Leu Arg Gln Gly Thr Phe Ile 
                485                 490                 495     


Lys Asp Asp Thr Leu Leu Val Arg Cys Glu Val Ser Thr Arg Phe Asp 
            500                 505                 510         


Met Gly Gly Leu Arg Lys Glu Gly Phe Gln Pro Arg Ser Thr Asp Ala 
        515                 520                 525             


Gly Val 
    530 


<210>  58
<211>  4414
<212>  DNA
<213>  Homo sapiens

<400>  58
atcgagcgcc taggagagcc ccgggtgggg gagggcgcaa ggggctcggg agggcccctc       60

cctgcgtcgg cgcccctgac ccgcccccag aggcagggtt ttgctgtatt gcacaggcta      120

gtctcaaact ccttggctca agtgatcctc ttgctttggt ctcccaaagt gctgcgatta      180

caggctccag acccagttcc tggacctgcc ctggaaaaga agtatcccgt agagatgagc      240

tcactgcagt tacttaatta acaatttgta agctgcaaaa atggcaatgg gccaaccaag      300

aacagctaca atttgaattt ttctatttcc agaaaatgct tggacagaag agatgagtac      360

tatttccact aaggcctaga attgcctact gtacaaatag tcctgatcag gcaatatacg      420

aatggcccaa ggaagccacc aaattgattt tcaggtttta catgacctgc gacaaaaatt      480

ccctgaagta cctgaagttg ttgtatccag gtgcatgtta cagaataata ataacctgga      540

tgcctgctgt gctgttctct ctcaggagag tacaagatat ctttatggtg aaggagactt      600

gaatttttca gatgattctg gaatttctgg tctacgcaat cacatgactt ctctcaactt      660

ggacttgcaa tcacagaaca tttaccacca tggaagagaa ggaagtagga tgaatggaag      720

taggactcta acgcacagca ttagtgatgg acaacttcaa ggtggccagt ccaatagtga      780

actatttcag caggagccac agacagcacc agctcaagtt cctcaaggct ttaatgtttt      840

tggaatgtcc agttcctctg gtgcttcaaa ttcagcacca catcttggat ttcacttagg      900

cagcaaagga acatctagcc tttctcaaca aactcccaga tttaatccca ttatggtaac      960

tttagcccca aatatccaga ctggtcgtaa tactcctaca tctttgcaca tacatggtgt     1020

acctccacct gtacttaaca gtccacaggg aaattctatc tatattaggc cttacattac     1080

aactcctggt ggtacaactc gacagacaca acagcattct ggctgggtat ctcagtttaa     1140

tcccatgaac cctcagcaag tttatcagcc ttcacagcct ggtccctgga ctacttgtcc     1200

tgcatctaat cctctgtcac atacctcatc tcaacagcca aatcagcaag gccaccagac     1260

ctctcatgtc tacatgccaa tcagttcacc tactacttca caaccaccaa ccattcattc     1320

atctggtagc tcacagtctt ctgcccatag ccaatataac attcagaata tttcaacagg     1380

acctcgaaaa aaccagattg aaatcaaact tgaaccccca caaagaaata attcttcaaa     1440

actgcgttct tctggacctc gaacctccag cacttcctct tcagtcaata gccagacctt     1500

aaacagaaat cagcccactg tttacatagc tgccagcccc ccaaatacgg atgagctgat     1560

gtcccgtagt caacctaagg tctatatttc agcgaatgct gccacaggag atgaacaggt     1620

catgcggaat cagcccacac tcttcatatc cacaaactct ggagcatctg ctgcctccag     1680

gaacatgtct gggcaagtga gcatgggtcc tgcctttatt catcaccatc ctcccaaaag     1740

tcgagcaata ggcaataact ctgcaacctc tcctcgagtg gtagtcactc agcccaatac     1800

gaaatacact ttcaaaatta cagtctctcc caataagccc cctgcagttt caccaggggt     1860

ggtgtcccct acctttgaac ttacaaatct tcttaatcat cctgatcatt atgtagaaac     1920

cgagaatatt cagcacctca cggaccctac attagcacat gtggatagaa taagtgaaac     1980

acggaaactg agtatgggat ctgatgatgc tgcctacaca caagctcttt tggtacacca     2040

gaaggccaga atggaacgac ttcaaagaga acttgagatt caaaagaaaa agctggataa     2100

attaaaatct gaggttaatg aaatggaaaa taatctaact cgaaggcgcc tgaaaagatc     2160

aaattctata tcccagatac cttcccttga agaaatgcag cagctgagaa gttgtaatag     2220

acaactccag attgacattg actgcttaac caaagaaatt gatctttttc aagcccgagg     2280

accacatttt aaccccagcg ctattcataa cttttatgac aatattggat ttgtaggtcc     2340

tgtgccacca aaacccaaag atcaaaggtc catcatcaaa acaccaaaga ctcaagacac     2400

agaagatgat gagggagctc agtggaattg taccgcctgt acttttttga accatccagc     2460

cttaattcgc tgtgaacagt gtgagatgcc aaggcatttc tgagccaaat ggccctgtat     2520

cttctctaaa accacatcta aagttcaaga aactagtctg tcatcgggaa aaagtttcac     2580

tgctacatag gattttgtca aattgaaggt gtgacaagat ggtgttctgc taatgttaaa     2640

tgtcagccca cagagctaat aatacctcag tataatgtca tgagcagttg aaattcatca     2700

catgaaaagt aatctgctga aagacttggt tgcccactgc ctaactgtgt acagtgttac     2760

cagtgtccca ttatggataa ttctcaatat gttaacacct aggtgttccc aatacctttt     2820

tcccctcatg tcactactga attttgacag gaggaaggaa tagaatgata gcttgtttta     2880

tttgtaaagc tttcagtgaa acactacata cacgaagaaa aggaacaagg tttaactatt     2940

taagaaccat ttgctgccgc atagtgccat tggataggga agaacttcag aaatctgtgg     3000

tactcttggc cttgtctttg tcttccctga acgtgtctcc actctgtgaa gccagcatct     3060

aggggctaaa gatgcaaagg aaagcagcat gcattgtctg tacaaatgtg cagcgaaata     3120

ccccaaagct tttcctactg tacagatctc tcgagtctgc tttaagtgat ttcttttctt     3180

cttgattatt ttcttatatt tctatatgta tagtgtaata gccttttgtt aactaatttt     3240

cttttttcct tttagtaatt aagcacgatc atgtcccttt ttaagcctta cctgagagga     3300

acaatgcctt aaaataaaaa agcattaatg agatgaaagt atgcacagaa taactttcct     3360

ctacttattc tgtactttgc cctcatgagt tccaatgttg tgtgaagaca ggcagatgct     3420

gcacagtgaa ttgcagatga tattacagaa gtgatgtctg taggtcacat taaatactga     3480

cttgagcagt gggtgacaca acacagtgtt tgtcttccac agggaagctt aaaacaaaag     3540

atatttttaa cccactgaca gaacaacaag gttaagcttc atctgcttgg tgtcccacag     3600

aacttgcaca agcagttgtt attgggaaag tacagtctca aaaccagcaa cagcagcagt     3660

acctacagcc ctttttttgg agagaagttt aaatgcttta ctgttggggc agtccatttc     3720

taatcctgac ttggtgacag tatcatgtgt atttataaaa caaggctagc catatttagg     3780

acaactgaag aaaagctgga aaaaaaaaca agcaaacttg aacactgaag caacctcaag     3840

catctcttta ttttgatgat atatttttgt aaggaaaata ttcagatgat caggaatgta     3900

tataactgaa atcaagaaaa agaacagtat gcatttaaaa agacagaatt atgaaattat     3960

atgagtgctt agaatggggc taagggaagt gctgaaatag agcaaaggat ggaagataat     4020

atagactacc acccactgta aatgtttgca agtggctgtg ttttaaatgg gattattaca     4080

gttgatctct atgaatgtca gagccctaac tttcaggctt tgcattttgt atatgggaag     4140

aaatatgaca atcctaggta attaaaccat agacccaaag cccttacgtt tgatgcaatt     4200

tatttttaaa ataggccttg tttttcagct tcatctgcag ttctatgtga agattgataa     4260

atcagttttt acttgtttta ttaataaaac gtaatttgga tatcttgagt tgatggtttt     4320

gtgatttagc tgggtaaact atctttgtaa cagataagtt atttataaaa attaaaaaac     4380

ttatattcta atgtggaaaa aaaaaaaaaa aaaa                                 4414


<210>  59
<211>  4171
<212>  DNA
<213>  Homo sapiens

<400>  59
ggaggcgacg gtggagacgg ctgccctagt gggagaggcg gcggcggcgg cggccgagga       60

ggaggagggg gaagcggcgg cggcaaagga aaatgcttgg acagaagaga tgagtactat      120

ttccactaag gcctagaatt gcctactgta caaatagtcc tgatcaggca atatacgaat      180

ggcccaagga agccaccaaa ttgattttca ggttttacat gacctgcgac aaaaattccc      240

tgaagtacct gaagttgttg tatccaggtg catgttacag aataataata acctggatgc      300

ctgctgtgct gttctctctc aggagagtac aagatatctt tatggtgaag gagacttgaa      360

tttttcagat gattctggaa tttctggtct acgcaatcac atgacttctc tcaacttgga      420

cttgcaatca cagaacattt accaccatgg aagagaagga agtaggatga atggaagtag      480

gactctaacg cacagcatta gtgatggaca acttcaaggt ggccagtcca atagtgaact      540

atttcagcag gagccacaga cagcaccagc tcaagttcct caaggcttta atgtttttgg      600

aatgtccagt tcctctggtg cttcaaattc agcaccacat cttggatttc acttaggcag      660

caaaggaaca tctagccttt ctcaacaaac tcccagattt aatcccatta tggtaacttt      720

agccccaaat atccagactg gtcgtaatac tcctacatct ttgcacatac atggtgtacc      780

tccacctgta cttaacagtc cacagggaaa ttctatctat attaggcctt acattacaac      840

tcctggtggt acaactcgac agacacaaca gcattctggc tgggtatctc agtttaatcc      900

catgaaccct cagcaagttt atcagccttc acagcctggt ccctggacta cttgtcctgc      960

atctaatcct ctgtcacata cctcatctca acagccaaat cagcaaggcc accagacctc     1020

tcatgtctac atgccaatca gttcacctac tacttcacaa ccaccaacca ttcattcatc     1080

tggtagctca cagtcttctg cccatagcca atataacatt cagaatattt caacaggacc     1140

tcgaaaaaac cagattgaaa tcaaacttga acccccacaa agaaataatt cttcaaaact     1200

gcgttcttct ggacctcgaa cctccagcac ttcctcttca gtcaatagcc agaccttaaa     1260

cagaaatcag cccactgttt acatagctgc cagcccccca aatacggatg agctgatgtc     1320

ccgtagtcaa cctaaggtct atatttcagc gaatgctgcc acaggagatg aacaggtcat     1380

gcggaatcag cccacactct tcatatccac aaactctgga gcatctgctg cctccaggaa     1440

catgtctggg caagtgagca tgggtcctgc ctttattcat caccatcctc ccaaaagtcg     1500

agcaataggc aataactctg caacctctcc tcgagtggta gtcactcagc ccaatacgaa     1560

atacactttc aaaattacag tctctcccaa taagccccct gcagtttcac caggggtggt     1620

gtcccctacc tttgaactta caaatcttct taatcatcct gatcattatg tagaaaccga     1680

gaatattcag cacctcacgg accctacatt agcacatgtg gatagaataa gtgaaacacg     1740

gaaactgagt atgggatctg atgatgctgc ctacacacaa gctcttttgg tacaccagaa     1800

ggccagaatg gaacgacttc aaagagaact tgagattcaa aagaaaaagc tggataaatt     1860

aaaatctgag gttaatgaaa tggaaaataa tctaactcga aggcgcctga aaagatcaaa     1920

ttctatatcc cagatacctt cccttgaaga aatgcagcag ctgagaagtt gtaatagaca     1980

actccagatt gacattgact gcttaaccaa agaaattgat ctttttcaag cccgaggacc     2040

acattttaac cccagcgcta ttcataactt ttatgacaat attggatttg taggtcctgt     2100

gccaccaaaa cccaaagatc aaaggtccat catcaaaaca ccaaagactc aagacacaga     2160

agatgatgag ggagctcagt ggaattgtac cgcctgtact tttttgaacc atccagcctt     2220

aattcgctgt gaacagtgtg agatgccaag gcatttctga gccaaatggc cctgtatctt     2280

ctctaaaacc acatctaaag ttcaagaaac tagtctgtca tcgggaaaaa gtttcactgc     2340

tacataggat tttgtcaaat tgaaggtgtg acaagatggt gttctgctaa tgttaaatgt     2400

cagcccacag agctaataat acctcagtat aatgtcatga gcagttgaaa ttcatcacat     2460

gaaaagtaat ctgctgaaag acttggttgc ccactgccta actgtgtaca gtgttaccag     2520

tgtcccatta tggataattc tcaatatgtt aacacctagg tgttcccaat acctttttcc     2580

cctcatgtca ctactgaatt ttgacaggag gaaggaatag aatgatagct tgttttattt     2640

gtaaagcttt cagtgaaaca ctacatacac gaagaaaagg aacaaggttt aactatttaa     2700

gaaccatttg ctgccgcata gtgccattgg atagggaaga acttcagaaa tctgtggtac     2760

tcttggcctt gtctttgtct tccctgaacg tgtctccact ctgtgaagcc agcatctagg     2820

ggctaaagat gcaaaggaaa gcagcatgca ttgtctgtac aaatgtgcag cgaaataccc     2880

caaagctttt cctactgtac agatctctcg agtctgcttt aagtgatttc ttttcttctt     2940

gattattttc ttatatttct atatgtatag tgtaatagcc ttttgttaac taattttctt     3000

ttttcctttt agtaattaag cacgatcatg tcccttttta agccttacct gagaggaaca     3060

atgccttaaa ataaaaaagc attaatgaga tgaaagtatg cacagaataa ctttcctcta     3120

cttattctgt actttgccct catgagttcc aatgttgtgt gaagacaggc agatgctgca     3180

cagtgaattg cagatgatat tacagaagtg atgtctgtag gtcacattaa atactgactt     3240

gagcagtggg tgacacaaca cagtgtttgt cttccacagg gaagcttaaa acaaaagata     3300

tttttaaccc actgacagaa caacaaggtt aagcttcatc tgcttggtgt cccacagaac     3360

ttgcacaagc agttgttatt gggaaagtac agtctcaaaa ccagcaacag cagcagtacc     3420

tacagccctt tttttggaga gaagtttaaa tgctttactg ttggggcagt ccatttctaa     3480

tcctgacttg gtgacagtat catgtgtatt tataaaacaa ggctagccat atttaggaca     3540

actgaagaaa agctggaaaa aaaaacaagc aaacttgaac actgaagcaa cctcaagcat     3600

ctctttattt tgatgatata tttttgtaag gaaaatattc agatgatcag gaatgtatat     3660

aactgaaatc aagaaaaaga acagtatgca tttaaaaaga cagaattatg aaattatatg     3720

agtgcttaga atggggctaa gggaagtgct gaaatagagc aaaggatgga agataatata     3780

gactaccacc cactgtaaat gtttgcaagt ggctgtgttt taaatgggat tattacagtt     3840

gatctctatg aatgtcagag ccctaacttt caggctttgc attttgtata tgggaagaaa     3900

tatgacaatc ctaggtaatt aaaccataga cccaaagccc ttacgtttga tgcaatttat     3960

ttttaaaata ggccttgttt ttcagcttca tctgcagttc tatgtgaaga ttgataaatc     4020

agtttttact tgttttatta ataaaacgta atttggatat cttgagttga tggttttgtg     4080

atttagctgg gtaaactatc tttgtaacag ataagttatt tataaaaatt aaaaaactta     4140

tattctaatg tggaaaaaaa aaaaaaaaaa a                                    4171


<210>  60
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Gln Gly Ser His Gln Ile Asp Phe Gln Val Leu His Asp Leu 
1               5                   10                  15      


Arg Gln Lys Phe Pro Glu Val Pro Glu Val Val Val Ser Arg Cys Met 
            20                  25                  30          


Leu Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln 
        35                  40                  45              


Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp 
    50                  55                  60                  


Asp Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Leu Gln Ser Gln Asn Ile Tyr His His Gly Arg Glu Gly Ser Arg 
                85                  90                  95      


Met Asn Gly Ser Arg Thr Leu Thr His Ser Ile Ser Asp Gly Gln Leu 
            100                 105                 110         


Gln Gly Gly Gln Ser Asn Ser Glu Leu Phe Gln Gln Glu Pro Gln Thr 
        115                 120                 125             


Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ala Ser Asn Ser Ala Pro His Leu Gly Phe His Leu Gly 
145                 150                 155                 160 


Ser Lys Gly Thr Ser Ser Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro 
                165                 170                 175     


Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Asn Thr Pro 
            180                 185                 190         


Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro 
        195                 200                 205             


Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Gly Gly 
    210                 215                 220                 


Thr Thr Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn 
225                 230                 235                 240 


Pro Met Asn Pro Gln Gln Val Tyr Gln Pro Ser Gln Pro Gly Pro Trp 
                245                 250                 255     


Thr Thr Cys Pro Ala Ser Asn Pro Leu Ser His Thr Ser Ser Gln Gln 
            260                 265                 270         


Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser 
        275                 280                 285             


Ser Pro Thr Thr Ser Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser 
    290                 295                 300                 


Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly 
305                 310                 315                 320 


Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn 
                325                 330                 335     


Asn Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ser Ser Thr Ser 
            340                 345                 350         


Ser Ser Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr 
        355                 360                 365             


Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Leu Met Ser Arg Ser Gln 
    370                 375                 380                 


Pro Lys Val Tyr Ile Ser Ala Asn Ala Ala Thr Gly Asp Glu Gln Val 
385                 390                 395                 400 


Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Ala Ser 
                405                 410                 415     


Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe 
            420                 425                 430         


Ile His His His Pro Pro Lys Ser Arg Ala Ile Gly Asn Asn Ser Ala 
        435                 440                 445             


Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe 
    450                 455                 460                 


Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val 
465                 470                 475                 480 


Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His 
                485                 490                 495     


Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Thr Leu Ala 
            500                 505                 510         


His Val Asp Arg Ile Ser Glu Thr Arg Lys Leu Ser Met Gly Ser Asp 
        515                 520                 525             


Asp Ala Ala Tyr Thr Gln Ala Leu Leu Val His Gln Lys Ala Arg Met 
    530                 535                 540                 


Glu Arg Leu Gln Arg Glu Leu Glu Ile Gln Lys Lys Lys Leu Asp Lys 
545                 550                 555                 560 


Leu Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg 
                565                 570                 575     


Leu Lys Arg Ser Asn Ser Ile Ser Gln Ile Pro Ser Leu Glu Glu Met 
            580                 585                 590         


Gln Gln Leu Arg Ser Cys Asn Arg Gln Leu Gln Ile Asp Ile Asp Cys 
        595                 600                 605             


Leu Thr Lys Glu Ile Asp Leu Phe Gln Ala Arg Gly Pro His Phe Asn 
    610                 615                 620                 


Pro Ser Ala Ile His Asn Phe Tyr Asp Asn Ile Gly Phe Val Gly Pro 
625                 630                 635                 640 


Val Pro Pro Lys Pro Lys Asp Gln Arg Ser Ile Ile Lys Thr Pro Lys 
                645                 650                 655     


Thr Gln Asp Thr Glu Asp Asp Glu Gly Ala Gln Trp Asn Cys Thr Ala 
            660                 665                 670         


Cys Thr Phe Leu Asn His Pro Ala Leu Ile Arg Cys Glu Gln Cys Glu 
        675                 680                 685             


Met Pro Arg His Phe 
    690             


<210>  61
<211>  4206
<212>  DNA
<213>  Homo sapiens

<400>  61
tcctttctgg agtctgaaat gttaagtatg gaggcaaaag ctgaagctgg agcaacagtc       60

tcagaatatg acaacaacca tgagaatgga ggccattcat agcagaacta cgagacaaga      120

ggagcctagg tccctgagct gcagaactgc atactaacct gatgagaaga ctaatgctca      180

gtgaggtgaa ctccttcagg gccacaggct gtaaagatct aaacaccatc tgatccagtt      240

tcaatatgac tgcctggatg aagaaggatt tgagactaag tttattcctc caaagcaaac      300

caactgagaa tgcagaataa taataacctg gatgcctgct gtgctgttct ctctcaggag      360

agtacaagat atctttatgg tgaaggagac ttgaattttt cagatgattc tggaatttct      420

ggtctacgca atcacatgac ttctctcaac ttggacttgc aatcacagaa catttaccac      480

catggaagag aaggaagtag gatgaatgga agtaggactc taacgcacag cattagtgat      540

ggacaacttc aaggtggcca gtccaatagt gaactatttc agcaggagcc acagacagca      600

ccagctcaag ttcctcaagg ctttaatgtt tttggaatgt ccagttcctc tggtgcttca      660

aattcagcac cacatcttgg atttcactta ggcagcaaag gaacatctag cctttctcaa      720

caaactccca gatttaatcc cattatggta actttagccc caaatatcca gactggtcgt      780

aatactccta catctttgca catacatggt gtacctccac ctgtacttaa cagtccacag      840

ggaaattcta tctatattag gccttacatt acaactcctg gtggtacaac tcgacagaca      900

caacagcatt ctggctgggt atctcagttt aatcccatga accctcagca agtttatcag      960

ccttcacagc ctggtccctg gactacttgt cctgcatcta atcctctgtc acatacctca     1020

tctcaacagc caaatcagca aggccaccag acctctcatg tctacatgcc aatcagttca     1080

cctactactt cacaaccacc aaccattcat tcatctggta gctcacagtc ttctgcccat     1140

agccaatata acattcagaa tatttcaaca ggacctcgaa aaaaccagat tgaaatcaaa     1200

cttgaacccc cacaaagaaa taattcttca aaactgcgtt cttctggacc tcgaacctcc     1260

agcacttcct cttcagtcaa tagccagacc ttaaacagaa atcagcccac tgtttacata     1320

gctgccagcc ccccaaatac ggatgagctg atgtcccgta gtcaacctaa ggtctatatt     1380

tcagcgaatg ctgccacagg agatgaacag gtcatgcgga atcagcccac actcttcata     1440

tccacaaact ctggagcatc tgctgcctcc aggaacatgt ctgggcaagt gagcatgggt     1500

cctgccttta ttcatcacca tcctcccaaa agtcgagcaa taggcaataa ctctgcaacc     1560

tctcctcgag tggtagtcac tcagcccaat acgaaataca ctttcaaaat tacagtctct     1620

cccaataagc cccctgcagt ttcaccaggg gtggtgtccc ctacctttga acttacaaat     1680

cttcttaatc atcctgatca ttatgtagaa accgagaata ttcagcacct cacggaccct     1740

acattagcac atgtggatag aataagtgaa acacggaaac tgagtatggg atctgatgat     1800

gctgcctaca cacaagctct tttggtacac cagaaggcca gaatggaacg acttcaaaga     1860

gaacttgaga ttcaaaagaa aaagctggat aaattaaaat ctgaggttaa tgaaatggaa     1920

aataatctaa ctcgaaggcg cctgaaaaga tcaaattcta tatcccagat accttccctt     1980

gaagaaatgc agcagctgag aagttgtaat agacaactcc agattgacat tgactgctta     2040

accaaagaaa ttgatctttt tcaagcccga ggaccacatt ttaaccccag cgctattcat     2100

aacttttatg acaatattgg atttgtaggt cctgtgccac caaaacccaa agatcaaagg     2160

tccatcatca aaacaccaaa gactcaagac acagaagatg atgagggagc tcagtggaat     2220

tgtaccgcct gtactttttt gaaccatcca gccttaattc gctgtgaaca gtgtgagatg     2280

ccaaggcatt tctgagccaa atggccctgt atcttctcta aaaccacatc taaagttcaa     2340

gaaactagtc tgtcatcggg aaaaagtttc actgctacat aggattttgt caaattgaag     2400

gtgtgacaag atggtgttct gctaatgtta aatgtcagcc cacagagcta ataatacctc     2460

agtataatgt catgagcagt tgaaattcat cacatgaaaa gtaatctgct gaaagacttg     2520

gttgcccact gcctaactgt gtacagtgtt accagtgtcc cattatggat aattctcaat     2580

atgttaacac ctaggtgttc ccaatacctt tttcccctca tgtcactact gaattttgac     2640

aggaggaagg aatagaatga tagcttgttt tatttgtaaa gctttcagtg aaacactaca     2700

tacacgaaga aaaggaacaa ggtttaacta tttaagaacc atttgctgcc gcatagtgcc     2760

attggatagg gaagaacttc agaaatctgt ggtactcttg gccttgtctt tgtcttccct     2820

gaacgtgtct ccactctgtg aagccagcat ctaggggcta aagatgcaaa ggaaagcagc     2880

atgcattgtc tgtacaaatg tgcagcgaaa taccccaaag cttttcctac tgtacagatc     2940

tctcgagtct gctttaagtg atttcttttc ttcttgatta ttttcttata tttctatatg     3000

tatagtgtaa tagccttttg ttaactaatt ttcttttttc cttttagtaa ttaagcacga     3060

tcatgtccct ttttaagcct tacctgagag gaacaatgcc ttaaaataaa aaagcattaa     3120

tgagatgaaa gtatgcacag aataactttc ctctacttat tctgtacttt gccctcatga     3180

gttccaatgt tgtgtgaaga caggcagatg ctgcacagtg aattgcagat gatattacag     3240

aagtgatgtc tgtaggtcac attaaatact gacttgagca gtgggtgaca caacacagtg     3300

tttgtcttcc acagggaagc ttaaaacaaa agatattttt aacccactga cagaacaaca     3360

aggttaagct tcatctgctt ggtgtcccac agaacttgca caagcagttg ttattgggaa     3420

agtacagtct caaaaccagc aacagcagca gtacctacag cccttttttt ggagagaagt     3480

ttaaatgctt tactgttggg gcagtccatt tctaatcctg acttggtgac agtatcatgt     3540

gtatttataa aacaaggcta gccatattta ggacaactga agaaaagctg gaaaaaaaaa     3600

caagcaaact tgaacactga agcaacctca agcatctctt tattttgatg atatattttt     3660

gtaaggaaaa tattcagatg atcaggaatg tatataactg aaatcaagaa aaagaacagt     3720

atgcatttaa aaagacagaa ttatgaaatt atatgagtgc ttagaatggg gctaagggaa     3780

gtgctgaaat agagcaaagg atggaagata atatagacta ccacccactg taaatgtttg     3840

caagtggctg tgttttaaat gggattatta cagttgatct ctatgaatgt cagagcccta     3900

actttcaggc tttgcatttt gtatatggga agaaatatga caatcctagg taattaaacc     3960

atagacccaa agcccttacg tttgatgcaa tttattttta aaataggcct tgtttttcag     4020

cttcatctgc agttctatgt gaagattgat aaatcagttt ttacttgttt tattaataaa     4080

acgtaatttg gatatcttga gttgatggtt ttgtgattta gctgggtaaa ctatctttgt     4140

aacagataag ttatttataa aaattaaaaa acttatattc taatgtggaa aaaaaaaaaa     4200

aaaaaa                                                                4206


<210>  62
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln 
1               5                   10                  15      


Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp 
            20                  25                  30          


Asp Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu 
        35                  40                  45              


Asp Leu Gln Ser Gln Asn Ile Tyr His His Gly Arg Glu Gly Ser Arg 
    50                  55                  60                  


Met Asn Gly Ser Arg Thr Leu Thr His Ser Ile Ser Asp Gly Gln Leu 
65                  70                  75                  80  


Gln Gly Gly Gln Ser Asn Ser Glu Leu Phe Gln Gln Glu Pro Gln Thr 
                85                  90                  95      


Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Ala Ser Asn Ser Ala Pro His Leu Gly Phe His Leu Gly 
        115                 120                 125             


Ser Lys Gly Thr Ser Ser Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro 
    130                 135                 140                 


Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Asn Thr Pro 
145                 150                 155                 160 


Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro 
                165                 170                 175     


Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Gly Gly 
            180                 185                 190         


Thr Thr Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn 
        195                 200                 205             


Pro Met Asn Pro Gln Gln Val Tyr Gln Pro Ser Gln Pro Gly Pro Trp 
    210                 215                 220                 


Thr Thr Cys Pro Ala Ser Asn Pro Leu Ser His Thr Ser Ser Gln Gln 
225                 230                 235                 240 


Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser 
                245                 250                 255     


Ser Pro Thr Thr Ser Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser 
            260                 265                 270         


Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly 
        275                 280                 285             


Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn 
    290                 295                 300                 


Asn Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ser Ser Thr Ser 
305                 310                 315                 320 


Ser Ser Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr 
                325                 330                 335     


Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Leu Met Ser Arg Ser Gln 
            340                 345                 350         


Pro Lys Val Tyr Ile Ser Ala Asn Ala Ala Thr Gly Asp Glu Gln Val 
        355                 360                 365             


Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Ala Ser 
    370                 375                 380                 


Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe 
385                 390                 395                 400 


Ile His His His Pro Pro Lys Ser Arg Ala Ile Gly Asn Asn Ser Ala 
                405                 410                 415     


Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe 
            420                 425                 430         


Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val 
        435                 440                 445             


Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His 
    450                 455                 460                 


Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Thr Leu Ala 
465                 470                 475                 480 


His Val Asp Arg Ile Ser Glu Thr Arg Lys Leu Ser Met Gly Ser Asp 
                485                 490                 495     


Asp Ala Ala Tyr Thr Gln Ala Leu Leu Val His Gln Lys Ala Arg Met 
            500                 505                 510         


Glu Arg Leu Gln Arg Glu Leu Glu Ile Gln Lys Lys Lys Leu Asp Lys 
        515                 520                 525             


Leu Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg 
    530                 535                 540                 


Leu Lys Arg Ser Asn Ser Ile Ser Gln Ile Pro Ser Leu Glu Glu Met 
545                 550                 555                 560 


Gln Gln Leu Arg Ser Cys Asn Arg Gln Leu Gln Ile Asp Ile Asp Cys 
                565                 570                 575     


Leu Thr Lys Glu Ile Asp Leu Phe Gln Ala Arg Gly Pro His Phe Asn 
            580                 585                 590         


Pro Ser Ala Ile His Asn Phe Tyr Asp Asn Ile Gly Phe Val Gly Pro 
        595                 600                 605             


Val Pro Pro Lys Pro Lys Asp Gln Arg Ser Ile Ile Lys Thr Pro Lys 
    610                 615                 620                 


Thr Gln Asp Thr Glu Asp Asp Glu Gly Ala Gln Trp Asn Cys Thr Ala 
625                 630                 635                 640 


Cys Thr Phe Leu Asn His Pro Ala Leu Ile Arg Cys Glu Gln Cys Glu 
                645                 650                 655     


Met Pro Arg His Phe 
            660     


<210>  63
<211>  4278
<212>  DNA
<213>  Mus musculus

<400>  63
gtgcgagccg gagccgagca gcgggccgcg gcgacgccgc cccggccatc gctttgatcc       60

gcggcaggcg ccggcggcgg ggcgccccag gccgaccccc tcccctcccc ctcagccgcg      120

agcggcggcg gcggccggag ggagttggcg gcggccgggc ggagggggcc gagcggggag      180

ggagggaggg ctgaggtgtc ccccctgccg ggtggaatcg gcgctggcgg cggccgcggt      240

gacgacgggg gagacggctg cccaagtggg agaggcggcg gcggcggacg aggaggaggg      300

ggaagccgcg gcggcggcga aggaaaatgc ttggccagaa gagatgagta ctaattccac      360

tcaggcctag aattgcctat tgagatagac ctgagcaggc gacatacgaa tggcccaagg      420

aagccaccaa attgattttc aggttttaca tgacctgcga caaaaattcc cagaagtgcc      480

tgaagttgtt gtatccaggt gcatgttaca gaacaataat aacctggatg cctgctgcgc      540

tgttctctct caggagagta caaggtatct ttatggtgaa ggagacctga atttttcaga      600

tgagtctgga atttctggtc tacgcaatca catgacttct ctcaacttgg acttgcagtc      660

acagaatgtt taccaccatg gaagagaagg aagtcgagtg aatggaagca ggactttaac      720

acacagcgtt agtgatggac agcttcacgg tgggcagtcc aataacgaac tgtttcagca      780

agagccacag acagcaccag ctcaagttcc tcaaggcttt aatgtttttg gaatgcccag      840

tacatctggt gcttcaaact caacaccgca tcttggattt cacctaggca gcaaagggac      900

atcaaacctt tctcaacaga ctcccaggtt caatcctatt atggtaactt tagccccaaa      960

catacagact ggccgtagta ctcctacatc tttgcacata catggtgtac ctccgcctgt     1020

actgaacagt ccacagggaa attctatcta tattaggcct tatattacaa ctcctagtgg     1080

tacagctcgg cagacacaac aacattctgg ctgggtgtct cagtttaatc ccatgaaccc     1140

tcagcaagcc tatcaacctt cacagcctgg accttggact acttatcctg catccaatcc     1200

tttgccacat acctcaaccc agcagccgaa tcagcagggc catcagacct ctcatgtcta     1260

catgcctatc agttcgccaa ctactccaca accgccaacc attcactcat ctgggagctc     1320

tcagtcttct gcccatagcc aatataacat tcagaatatt tcaacaggac ctcgaaagaa     1380

ccagatagaa atcaaacttg aacccccaca aagaaacagt tcttcaaaat tacgttcttc     1440

tggacctcga actgccagca cttcctcatt ggtcaacagc cagaccttaa atagaaatca     1500

gcccactgtt tacatagctg ccagtcctcc aaatactgat gagatgatct cccgtagtca     1560

acccaaggtc tatatttcag ccaatgccac cgcaggagat gagcaaggca tgcggaatca     1620

accgacactc ttcatatcta caaactctgg gccatctgca gcctccagga acatgtctgg     1680

gcaagtgagc atgggtcctg cctttatcca tcaccatcca cccaaaagcc gagtgttagg     1740

tggtaactct gcaacgtctc ctcgagtggt ggtcactcaa cccaacacaa aatatacttt     1800

caaaattaca gtttccccca ataagccccc tgctgtttcc ccgggggtgg tctccccaac     1860

ctttgaactt acaaatcttc taaatcatcc tgaccattat gtagaaacag agaacattca     1920

gcatctcaca gacccggctc tagcacatgt ggatagaata agcgaagccc ggaaactgag     1980

tatgggatct gatgatgctg cctacacaca agctctgctg gtgcaccaga aggccaggat     2040

ggaacggctt caaagagagc tcgagatgca aaagaaaaag ctggataaac tcaaatctga     2100

ggtcaatgag atggaaaata atctaactcg aaggcgcctg aagagatcaa attccatttc     2160

ccagataccg tcactcgaag aaatgcagca gttgagaagt tgtaatagac aactccagat     2220

tgacattgac tgcttaacca aagaaattga tctttttcaa gcccgaggac cacattttaa     2280

ccccagcgct attcataact tttatgacaa tattggattt gtaggccctg tgccaccaaa     2340

acccaaagat caaaggtcca ccatcaaagc accaaagacc caagacgcag aggatgagga     2400

aggtgctcag tggaattgca ctgcctgtac gtttctgaat cacccggcct taatccgctg     2460

tgaacagtgt gagatgcctc ggcatttctg agccaaaggc cccgccttcc tctgaaacca     2520

catctaaagt tcaagaaggt cgcctgtcat cgggaaagtg tttcaccgcc acaggagtta     2580

gtccagttga aggtgtgacg agacagtggt gtgctgtgtt gagtgtcagc ccacagagct     2640

aatgatacct caatctaatg tcatgggcag tgagattcat cacctgaaag gcctgagaga     2700

ccgggctgcc tgctgcctga ccatgtccag tgtcacgtgt cagtgcctag gtgttcccag     2760

gactcctccc ctcttgtcac cactgatcct gacgggagga agggagagac aggatgattg     2820

ctttttgtgt tgttagagct tttggtgaaa cactacatac acaaagagaa ggaacaaggt     2880

ttgactgaga actctgctgc cacatagtgc cagtagatgt gggaaacgcc acaaatctgg     2940

ggtacttttg gccctgtcct ctgtcttctg aggacatctc tgtgaagcca gcatttaggt     3000

gtgagataaa aggaaagctg tgtctgtctg tacatccaca gtgcgctccc caagcctctc     3060

ctactgtaca gatgtctcac gtctgctttg atttctccat tatcttctta tatttctata     3120

tgtatagtgt aatagacttg tgttaactag tgtccttttc ccttttagta agcacgatca     3180

tgctcctttt aagccttacc tgagaaaagc aatgccataa ggtagaaagc attaatgaaa     3240

tgaaactgtg cacaacataa ctccctctcc ccttcctcct cctgtccttt gtcccttggt     3300

gccaatgctc tgagaagaca tgcaggtgct gcatgtgagt cactgcaaga aacactgcag     3360

ccatcggacg gtcgaggtca cgctgtacac tgacttgagc agtgggtgac caaacatgtc     3420

gttttgtctt ctccagcagc ttaaagcaga aagtatttaa acccactgcc atcttgcccc     3480

atctgtgtgg tatcccatag aactccatgg gaggctcttg ttgggaaaat gcagttttaa     3540

gaagcagcct cagcagccgt tcccgcagcc tcttcttccc gggaagaagt gtggctgtcg     3600

gactgttggc acagtcatgt gtatttataa agcatagtca tctttaggac aactgaagaa     3660

aagctggaaa aaagaaagaa aacaagcaga cttgaacact gaagcaacct cagacatctc     3720

tttattttga tgatatattt ttgtaaggaa aataaatatt catatgatca ggaatgtata     3780

taactaaatg aaatcaagaa aaaataacca tatgcatttt aaaagaatta tgaaattatc     3840

agtgcttgga atggggctaa gggaagtgct gaaatataag aaaaaaatag gaaataatgt     3900

agattgtccc actgtaaatg ttcacaagtg gctatgtttt aaataaacag gattattatg     3960

aatgagcgtt aagaaggtca gagcctggcc ttccgggctt tgcactgtga gtatggaaag     4020

agatacggca accataggtc actaggcaac agaccccaaa actcgtacat ttgatgcatt     4080

gtgttttaaa agtaggcctt gtttttcagc ttcctctgca gttctatgtg aagattgata     4140

aatcagtttt tacttgtttt attaataaaa cgtaatttgg atatcttgag ttgatggttt     4200

tgtgatttag ctgggtaaac tatctttgta acagataagt tatttataaa aattaaaaaa     4260

acttatattc taatgtgg                                                   4278


<210>  64
<211>  693
<212>  PRT
<213>  Mus musculus

<400>  64

Met Ala Gln Gly Ser His Gln Ile Asp Phe Gln Val Leu His Asp Leu 
1               5                   10                  15      


Arg Gln Lys Phe Pro Glu Val Pro Glu Val Val Val Ser Arg Cys Met 
            20                  25                  30          


Leu Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln 
        35                  40                  45              


Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp 
    50                  55                  60                  


Glu Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu 
65                  70                  75                  80  


Asp Leu Gln Ser Gln Asn Val Tyr His His Gly Arg Glu Gly Ser Arg 
                85                  90                  95      


Val Asn Gly Ser Arg Thr Leu Thr His Ser Val Ser Asp Gly Gln Leu 
            100                 105                 110         


His Gly Gly Gln Ser Asn Asn Glu Leu Phe Gln Gln Glu Pro Gln Thr 
        115                 120                 125             


Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Pro Ser 
    130                 135                 140                 


Thr Ser Gly Ala Ser Asn Ser Thr Pro His Leu Gly Phe His Leu Gly 
145                 150                 155                 160 


Ser Lys Gly Thr Ser Asn Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro 
                165                 170                 175     


Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Ser Thr Pro 
            180                 185                 190         


Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro 
        195                 200                 205             


Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Ser Gly 
    210                 215                 220                 


Thr Ala Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn 
225                 230                 235                 240 


Pro Met Asn Pro Gln Gln Ala Tyr Gln Pro Ser Gln Pro Gly Pro Trp 
                245                 250                 255     


Thr Thr Tyr Pro Ala Ser Asn Pro Leu Pro His Thr Ser Thr Gln Gln 
            260                 265                 270         


Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser 
        275                 280                 285             


Ser Pro Thr Thr Pro Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser 
    290                 295                 300                 


Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly 
305                 310                 315                 320 


Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn 
                325                 330                 335     


Ser Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ala Ser Thr Ser 
            340                 345                 350         


Ser Leu Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr 
        355                 360                 365             


Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Met Ile Ser Arg Ser Gln 
    370                 375                 380                 


Pro Lys Val Tyr Ile Ser Ala Asn Ala Thr Ala Gly Asp Glu Gln Gly 
385                 390                 395                 400 


Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Pro Ser 
                405                 410                 415     


Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe 
            420                 425                 430         


Ile His His His Pro Pro Lys Ser Arg Val Leu Gly Gly Asn Ser Ala 
        435                 440                 445             


Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe 
    450                 455                 460                 


Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val 
465                 470                 475                 480 


Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His 
                485                 490                 495     


Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Ala Leu Ala 
            500                 505                 510         


His Val Asp Arg Ile Ser Glu Ala Arg Lys Leu Ser Met Gly Ser Asp 
        515                 520                 525             


Asp Ala Ala Tyr Thr Gln Ala Leu Leu Val His Gln Lys Ala Arg Met 
    530                 535                 540                 


Glu Arg Leu Gln Arg Glu Leu Glu Met Gln Lys Lys Lys Leu Asp Lys 
545                 550                 555                 560 


Leu Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg 
                565                 570                 575     


Leu Lys Arg Ser Asn Ser Ile Ser Gln Ile Pro Ser Leu Glu Glu Met 
            580                 585                 590         


Gln Gln Leu Arg Ser Cys Asn Arg Gln Leu Gln Ile Asp Ile Asp Cys 
        595                 600                 605             


Leu Thr Lys Glu Ile Asp Leu Phe Gln Ala Arg Gly Pro His Phe Asn 
    610                 615                 620                 


Pro Ser Ala Ile His Asn Phe Tyr Asp Asn Ile Gly Phe Val Gly Pro 
625                 630                 635                 640 


Val Pro Pro Lys Pro Lys Asp Gln Arg Ser Thr Ile Lys Ala Pro Lys 
                645                 650                 655     


Thr Gln Asp Ala Glu Asp Glu Glu Gly Ala Gln Trp Asn Cys Thr Ala 
            660                 665                 670         


Cys Thr Phe Leu Asn His Pro Ala Leu Ile Arg Cys Glu Gln Cys Glu 
        675                 680                 685             


Met Pro Arg His Phe 
    690             


<210>  65
<211>  2950
<212>  PRT
<213>  Homo sapiens

<400>  65

Ala Gly Thr Cys Thr Cys Cys Gly Gly Gly Gly Ala Cys Thr Thr Thr 
1               5                   10                  15      


Cys Cys Cys Ala Gly Gly Gly Gly Thr Gly Gly Gly Gly Cys Gly Gly 
            20                  25                  30          


Cys Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly 
        35                  40                  45              


Gly Cys Ala Cys Thr Thr Cys Cys Thr Cys Gly Thr Cys Cys Thr Cys 
    50                  55                  60                  


Gly Gly Cys Cys Cys Gly Gly Gly Thr Gly Cys Cys Cys Thr Gly Cys 
65                  70                  75                  80  


Cys Cys Cys Cys Gly Thr Cys Cys Ala Gly Gly Ala Gly Cys Cys Cys 
                85                  90                  95      


Thr Ala Gly Gly Ala Gly Thr Gly Cys Thr Ala Cys Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Cys Cys Gly Gly Ala Gly Cys Cys Thr Thr Gly Cys Cys Cys 
        115                 120                 125             


Gly Gly Gly Cys Cys Gly Cys Thr Gly Cys Cys Cys Cys Gly Thr Cys 
    130                 135                 140                 


Cys Cys Thr Gly Gly Ala Thr Thr Cys Gly Gly Gly Gly Cys Thr Gly 
145                 150                 155                 160 


Gly Ala Cys Gly Cys Ala Gly Cys Ala Ala Gly Cys Gly Gly Gly Gly 
                165                 170                 175     


Cys Gly Cys Thr Gly Thr Gly Thr Cys Cys Cys Cys Ala Ala Gly Cys 
            180                 185                 190         


Thr Cys Cys Cys Cys Gly Thr Cys Cys Thr Cys Gly Gly Cys Cys Ala 
        195                 200                 205             


Gly Gly Cys Gly Gly Gly Cys Ala Cys Cys Ala Cys Gly Gly Cys Ala 
    210                 215                 220                 


Gly Gly Gly Gly Cys Thr Gly Ala Gly Cys Thr Ala Cys Cys Cys Thr 
225                 230                 235                 240 


Cys Ala Thr Gly Gly Ala Ala Gly Gly Gly Ala Gly Ala Gly Gly Ala 
                245                 250                 255     


Cys Cys Gly Thr Ala Cys Cys Gly Gly Ala Thr Cys Thr Ala Cys Gly 
            260                 265                 270         


Ala Cys Cys Cys Thr Gly Gly Gly Gly Gly Cys Ala Gly Cys Gly Thr 
        275                 280                 285             


Gly Cys Cys Cys Thr Cys Ala Gly Gly Ala Gly Ala Gly Gly Cys Ala 
    290                 295                 300                 


Thr Cys Cys Gly Cys Ala Gly Cys Thr Thr Thr Thr Gly Ala Gly Cys 
305                 310                 315                 320 


Gly Cys Cys Thr Ala Gly Thr Gly Ala Ala Gly Gly Ala Gly Ala Ala 
                325                 330                 335     


Thr Thr Cys Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Gly Ala Ala 
            340                 345                 350         


Ala Ala Ala Ala Thr Gly Cys Ala Ala Gly Gly Gly Ala Thr Ala Ala 
        355                 360                 365             


Ala Gly Ala Thr Gly Thr Thr Ala Gly Gly Gly Gly Ala Gly Cys Thr 
    370                 375                 380                 


Thr Thr Thr Gly Gly Ala Ala Gly Ala Gly Thr Cys Cys Cys Ala Gly 
385                 390                 395                 400 


Ala Thr Gly Gly Ala Ala Gly Cys Gly Ala Cys Cys Ala Gly Gly Cys 
                405                 410                 415     


Thr Cys Cys Gly Gly Cys Ala Gly Ala Ala Gly Gly Cys Ala Gly Ala 
            420                 425                 430         


Gly Gly Ala Gly Cys Thr Ala Gly Thr Gly Ala Ala Gly Gly Ala Cys 
        435                 440                 445             


Ala Ala Cys Gly Ala Gly Cys Thr Gly Cys Thr Cys Cys Cys Ala Cys 
    450                 455                 460                 


Cys Ala Cys Cys Thr Thr Cys Thr Cys Cys Cys Thr Cys Cys Thr Thr 
465                 470                 475                 480 


Gly Gly Gly Cys Thr Cys Cys Thr Thr Cys Gly Ala Cys Cys Cys Cys 
                485                 490                 495     


Cys Thr Gly Gly Cys Thr Gly Ala Gly Cys Thr Cys Ala Cys Ala Gly 
            500                 505                 510         


Gly Ala Ala Ala Gly Gly Ala Cys Thr Cys Ala Ala Ala Thr Gly Thr 
        515                 520                 525             


Cys Ala Cys Ala Gly Cys Ala Thr Cys Thr Cys Cys Cys Ala Cys Ala 
    530                 535                 540                 


Gly Cys Cys Cys Cys Thr Gly Cys Ala Thr Gly Cys Cys Cys Cys Ala 
545                 550                 555                 560 


Gly Thr Gly Ala Cys Ala Ala Gly Cys Cys Ala Gly Cys Ala Cys Cys 
                565                 570                 575     


Ala Gly Thr Cys Cys Ala Gly Ala Ala Gly Cys Cys Thr Cys Cys Ala 
            580                 585                 590         


Thr Cys Cys Ala Gly Thr Gly Gly Cys Ala Cys Cys Thr Cys Cys Thr 
        595                 600                 605             


Cys Thr Gly Ala Ala Thr Thr Thr Gly Ala Ala Gly Thr Gly Gly Thr 
    610                 615                 620                 


Cys Ala Cys Thr Cys Cys Thr Gly Ala Gly Gly Ala Gly Cys Ala Gly 
625                 630                 635                 640 


Ala Ala Thr Thr Cys Ala Cys Cys Ala Gly Ala Gly Ala Gly Cys Ala 
                645                 650                 655     


Gly Cys Ala Gly Cys Cys Ala Thr Gly Cys Cys Ala Ala Thr Gly Cys 
            660                 665                 670         


Gly Ala Thr Gly Gly Cys Gly Cys Thr Gly Gly Gly Cys Cys Cys Cys 
        675                 680                 685             


Cys Thr Gly Cys Cys Cys Cys Gly Thr Gly Ala Gly Gly Ala Cys Gly 
    690                 695                 700                 


Gly Cys Ala Ala Cys Cys Thr Gly Ala Thr Gly Cys Thr Gly Cys Ala 
705                 710                 715                 720 


Cys Cys Thr Gly Cys Ala Gly Cys Gly Cys Cys Thr Gly Gly Ala Gly 
                725                 730                 735     


Ala Cys Cys Ala Cys Gly Cys Thr Gly Ala Gly Thr Gly Thr Gly Thr 
            740                 745                 750         


Gly Thr Gly Cys Cys Gly Ala Gly Gly Ala Gly Cys Cys Gly Gly Ala 
        755                 760                 765             


Cys Cys Ala Cys Gly Gly Cys Cys Ala Gly Cys Thr Cys Thr Thr Cys 
    770                 775                 780                 


Ala Cys Cys Cys Ala Cys Cys Thr Gly Gly Gly Cys Cys Gly Cys Ala 
785                 790                 795                 800 


Thr Gly Gly Cys Cys Cys Thr Gly Gly Ala Gly Thr Thr Cys Ala Ala 
                805                 810                 815     


Cys Cys Gly Ala Cys Thr Gly Gly Cys Ala Thr Cys Cys Ala Ala Gly 
            820                 825                 830         


Gly Thr Gly Cys Ala Cys Ala Ala Gly Ala Ala Thr Gly Ala Gly Cys 
        835                 840                 845             


Ala Gly Cys Gly Cys Ala Cys Cys Thr Cys Cys Ala Thr Thr Cys Thr 
    850                 855                 860                 


Gly Cys Ala Gly Ala Cys Cys Cys Thr Gly Thr Gly Thr Gly Ala Gly 
865                 870                 875                 880 


Cys Ala Gly Cys Thr Thr Cys Gly Gly Ala Ala Gly Gly Ala Gly Ala 
                885                 890                 895     


Ala Cys Gly Ala Gly Gly Cys Thr Cys Thr Gly Ala Ala Gly Gly Cys 
            900                 905                 910         


Cys Ala Ala Gly Thr Thr Gly Gly Ala Thr Ala Ala Gly Gly Gly Cys 
        915                 920                 925             


Cys Thr Gly Gly Ala Ala Cys Ala Gly Cys Gly Gly Gly Ala Thr Cys 
    930                 935                 940                 


Ala Gly Gly Cys Thr Gly Cys Cys Gly Ala Gly Ala Gly Gly Cys Thr 
945                 950                 955                 960 


Gly Cys Gly Gly Gly Ala Gly Gly Ala Ala Ala Ala Thr Thr Thr Gly 
                965                 970                 975     


Gly Ala Gly Cys Thr Cys Ala Ala Gly Ala Ala Gly Thr Thr Gly Thr 
            980                 985                 990         


Thr Gly Ala Thr Gly Ala Gly Cys  Ala Ala Thr Gly Gly  Cys Ala Ala 
        995                 1000                 1005             


Cys Ala  Ala Ala Gly Ala Gly  Gly Gly Thr Gly Cys  Gly Thr Cys 
    1010                 1015                 1020             


Thr Gly  Gly Gly Cys Gly Gly  Cys Cys Ala Gly Gly  Cys Thr Cys 
    1025                 1030                 1035             


Ala Cys  Cys Gly Ala Ala Gly  Ala Thr Gly Gly Ala  Ala Gly Gly 
    1040                 1045                 1050             


Gly Ala  Cys Ala Gly Gly Cys  Ala Ala Gly Ala Ala  Gly Gly Cys 
    1055                 1060                 1065             


Ala Gly  Thr Gly Gly Cys Thr  Gly Gly Ala Cys Ala  Gly Cys Ala 
    1070                 1075                 1080             


Gly Cys  Ala Gly Gly Cys Thr  Ala Gly Thr Gly Thr  Gly Ala Cys 
    1085                 1090                 1095             


Gly Gly  Cys Ala Gly Gly Thr  Ala Ala Gly Gly Thr  Cys Cys Cys 
    1100                 1105                 1110             


Ala Gly  Ala Gly Gly Thr Gly  Gly Thr Gly Gly Cys  Cys Thr Thr 
    1115                 1120                 1125             


Gly Gly  Gly Cys Gly Cys Ala  Gly Cys Cys Gly Ala  Gly Ala Ala 
    1130                 1135                 1140             


Gly Ala  Ala Gly Gly Thr Gly  Ala Ala Gly Ala Thr  Gly Cys Thr 
    1145                 1150                 1155             


Gly Gly  Ala Gly Cys Ala Gly  Cys Ala Gly Cys Gly  Cys Ala Gly 
    1160                 1165                 1170             


Thr Gly  Ala Gly Cys Thr Gly  Cys Thr Gly Gly Ala  Ala Gly Thr 
    1175                 1180                 1185             


Gly Ala  Ala Cys Ala Ala Gly  Cys Ala Gly Thr Gly  Gly Gly Ala 
    1190                 1195                 1200             


Cys Cys  Ala Gly Cys Ala Thr  Thr Thr Cys Cys Gly  Gly Thr Cys 
    1205                 1210                 1215             


Cys Ala  Thr Gly Ala Ala Gly  Cys Ala Gly Cys Ala  Gly Thr Ala 
    1220                 1225                 1230             


Thr Gly  Ala Gly Cys Ala Gly  Ala Ala Gly Ala Thr  Cys Ala Cys 
    1235                 1240                 1245             


Thr Gly  Ala Gly Cys Thr Gly  Cys Gly Thr Cys Ala  Gly Ala Ala 
    1250                 1255                 1260             


Gly Cys  Thr Gly Gly Cys Thr  Gly Ala Thr Thr Thr  Gly Cys Ala 
    1265                 1270                 1275             


Gly Ala  Ala Gly Cys Ala Gly  Gly Thr Gly Ala Cys  Thr Gly Ala 
    1280                 1285                 1290             


Cys Cys  Thr Gly Gly Ala Gly  Gly Cys Cys Gly Ala  Gly Cys Gly 
    1295                 1300                 1305             


Gly Gly  Ala Gly Cys Ala Gly  Ala Ala Gly Cys Ala  Gly Cys Gly 
    1310                 1315                 1320             


Thr Gly  Ala Cys Thr Thr Thr  Gly Ala Cys Cys Gly  Cys Ala Ala 
    1325                 1330                 1335             


Gly Cys  Thr Cys Cys Thr Cys  Cys Thr Gly Gly Cys  Cys Ala Ala 
    1340                 1345                 1350             


Gly Thr  Cys Cys Ala Ala Gly  Ala Thr Thr Gly Ala  Ala Ala Thr 
    1355                 1360                 1365             


Gly Gly  Ala Gly Gly Ala Gly  Ala Cys Cys Gly Ala  Cys Ala Ala 
    1370                 1375                 1380             


Gly Gly  Ala Gly Cys Ala Gly  Cys Thr Gly Ala Cys  Ala Gly Cys 
    1385                 1390                 1395             


Ala Gly  Ala Gly Gly Cys Cys  Ala Ala Gly Gly Ala  Gly Cys Thr 
    1400                 1405                 1410             


Gly Cys  Gly Cys Cys Ala Ala  Ala Ala Gly Gly Thr  Cys Ala Ala 
    1415                 1420                 1425             


Gly Thr  Ala Cys Cys Thr Gly  Cys Ala Gly Gly Ala  Thr Cys Ala 
    1430                 1435                 1440             


Gly Cys  Thr Gly Ala Gly Cys  Cys Cys Ala Cys Thr  Cys Ala Cys 
    1445                 1450                 1455             


Cys Cys  Gly Ala Cys Ala Gly  Cys Gly Thr Gly Ala  Gly Thr Ala 
    1460                 1465                 1470             


Cys Cys  Ala Gly Gly Ala Ala  Ala Ala Gly Gly Ala  Gly Ala Thr 
    1475                 1480                 1485             


Cys Cys  Ala Gly Cys Gly Gly  Cys Thr Cys Ala Ala  Cys Ala Ala 
    1490                 1495                 1500             


Gly Gly  Cys Cys Cys Thr Gly  Gly Ala Gly Gly Ala  Ala Gly Cys 
    1505                 1510                 1515             


Ala Cys  Thr Gly Ala Gly Cys  Ala Thr Cys Cys Ala  Ala Ala Cys 
    1520                 1525                 1530             


Cys Cys  Cys Gly Cys Cys Ala  Thr Cys Ala Thr Cys  Thr Cys Cys 
    1535                 1540                 1545             


Ala Cys  Cys Ala Ala Cys Ala  Gly Cys Ala Thr Thr  Thr Gly Gly 
    1550                 1555                 1560             


Gly Ala  Gly Cys Cys Cys Ala  Gly Ala Ala Gly Gly  Ala Gly Cys 
    1565                 1570                 1575             


Ala Gly  Gly Gly Gly Cys Cys  Cys Thr Cys Cys Thr  Ala Ala Gly 
    1580                 1585                 1590             


Gly Ala  Ala Ala Cys Ala Gly  Gly Ala Gly Cys Thr  Gly Gly Thr 
    1595                 1600                 1605             


Cys Ala  Cys Gly Cys Ala Gly  Ala Ala Thr Gly Ala  Gly Thr Thr 
    1610                 1615                 1620             


Gly Cys  Thr Gly Ala Ala Ala  Cys Ala Gly Cys Ala  Gly Gly Thr 
    1625                 1630                 1635             


Gly Ala  Ala Gly Ala Thr Cys  Thr Thr Cys Gly Ala  Gly Gly Ala 
    1640                 1645                 1650             


Gly Gly  Ala Cys Thr Thr Cys  Cys Ala Gly Ala Gly  Gly Gly Ala 
    1655                 1660                 1665             


Gly Cys  Gly Cys Ala Gly Thr  Gly Ala Thr Cys Gly  Thr Gly Ala 
    1670                 1675                 1680             


Gly Cys  Gly Cys Ala Thr Gly  Ala Ala Thr Gly Ala  Gly Gly Ala 
    1685                 1690                 1695             


Gly Ala  Ala Gly Gly Ala Ala  Gly Ala Gly Cys Thr  Gly Ala Ala 
    1700                 1705                 1710             


Gly Ala  Ala Gly Cys Ala Ala  Gly Thr Gly Gly Ala  Gly Ala Ala 
    1715                 1720                 1725             


Gly Cys  Thr Gly Cys Ala Gly  Gly Cys Cys Cys Ala  Gly Gly Thr 
    1730                 1735                 1740             


Cys Ala  Cys Cys Cys Thr Gly  Thr Cys Ala Ala Ala  Thr Gly Cys 
    1745                 1750                 1755             


Cys Cys  Ala Gly Cys Thr Ala  Ala Ala Ala Gly Cys  Ala Thr Thr 
    1760                 1765                 1770             


Cys Ala  Ala Ala Gly Ala Thr  Gly Ala Gly Gly Ala  Gly Ala Ala 
    1775                 1780                 1785             


Gly Gly  Cys Ala Ala Gly Ala  Gly Ala Ala Gly Cys  Cys Cys Thr 
    1790                 1795                 1800             


Cys Ala  Gly Ala Cys Ala Gly  Cys Ala Gly Ala Ala  Gly Ala Gly 
    1805                 1810                 1815             


Gly Ala  Ala Ala Gly Cys Ala  Ala Ala Gly Gly Cys  Cys Thr Cys 
    1820                 1825                 1830             


Ala Gly  Gly Ala Gly Ala Gly  Cys Gly Thr Thr Ala  Cys Cys Ala 
    1835                 1840                 1845             


Thr Gly  Thr Gly Gly Ala Gly  Cys Cys Cys Cys Ala  Cys Cys Cys 
    1850                 1855                 1860             


Ala Gly  Ala Ala Cys Ala Thr  Cys Thr Cys Thr Gly  Cys Gly Gly 
    1865                 1870                 1875             


Gly Gly  Cys Cys Thr Ala Cys  Cys Cys Cys Thr Ala  Cys Gly Cys 
    1880                 1885                 1890             


Cys Thr  Ala Cys Cys Cys Gly  Cys Cys Cys Ala Thr  Gly Cys Cys 
    1895                 1900                 1905             


Ala Gly  Cys Cys Ala Thr Gly  Gly Thr Gly Cys Cys  Ala Cys Ala 
    1910                 1915                 1920             


Cys Cys  Ala Thr Gly Gly Cys  Thr Thr Cys Gly Ala  Gly Gly Ala 
    1925                 1930                 1935             


Cys Thr  Gly Gly Thr Cys Cys  Cys Ala Gly Ala Thr  Cys Cys Gly 
    1940                 1945                 1950             


Cys Thr  Ala Cys Cys Cys Cys  Cys Cys Thr Cys Cys  Cys Cys Cys 
    1955                 1960                 1965             


Cys Ala  Thr Gly Gly Cys Cys  Ala Thr Gly Gly Ala  Gly Cys Ala 
    1970                 1975                 1980             


Cys Cys  Cys Gly Cys Cys Cys  Cys Cys Ala Cys Thr  Cys Cys Cys 
    1985                 1990                 1995             


Cys Ala  Ala Cys Thr Cys Gly  Cys Gly Cys Cys Thr  Cys Thr Thr 
    2000                 2005                 2010             


Cys Cys  Ala Thr Cys Thr Gly  Cys Ala Cys Cys Ala  Gly Thr Thr 
    2015                 2020                 2025             


Thr Thr  Gly Thr Cys Gly Cys  Ala Gly Cys Cys Gly  Gly Ala Ala 
    2030                 2035                 2040             


Thr Ala  Cys Ala Cys Cys Thr  Gly Gly Cys Gly Thr  Cys Thr Ala 
    2045                 2050                 2055             


Cys Cys  Cys Thr Gly Thr Gly  Gly Ala Gly Gly Gly  Gly Thr Thr 
    2060                 2065                 2070             


Cys Gly  Ala Ala Ala Thr Cys  Cys Ala Ala Ala Thr  Cys Ala Gly 
    2075                 2080                 2085             


Ala Gly  Cys Thr Cys Cys Cys  Ala Ala Gly Thr Gly  Ala Thr Gly 
    2090                 2095                 2100             


Gly Ala  Cys Cys Cys Thr Cys  Cys Cys Ala Cys Ala  Gly Cys Cys 
    2105                 2110                 2115             


Ala Gly  Gly Cys Cys Thr Ala  Cys Ala Gly Ala Ala  Cys Cys Ala 
    2120                 2125                 2130             


Gly Ala  Gly Thr Cys Thr Cys  Cys Ala Ala Ala Ala  Ala Ala Thr 
    2135                 2140                 2145             


Gly Ala  Cys Cys Gly Thr Gly  Ala Gly Gly Gly Gly  Cys Cys Thr 
    2150                 2155                 2160             


Cys Ala  Gly Thr Gly Ala Gly  Ala Cys Cys Ala Gly  Ala Thr Thr 
    2165                 2170                 2175             


Gly Thr  Gly Thr Cys Ala Thr  Thr Thr Gly Gly Cys  Thr Cys Cys 
    2180                 2185                 2190             


Ala Cys  Cys Thr Thr Cys Ala  Thr Cys Thr Thr Gly  Cys Ala Gly 
    2195                 2200                 2205             


Ala Gly  Cys Cys Ala Gly Cys  Thr Gly Ala Thr Cys  Thr Cys Ala 
    2210                 2215                 2220             


Gly Ala  Thr Thr Gly Cys Cys  Ala Ala Gly Ala Ala  Ala Cys Thr 
    2225                 2230                 2235             


Ala Gly  Ala Ala Gly Cys Cys  Ala Cys Thr Thr Gly  Cys Ala Cys 
    2240                 2245                 2250             


Gly Gly  Thr Gly Thr Gly Gly  Cys Cys Ala Gly Ala  Gly Cys Cys 
    2255                 2260                 2265             


Thr Cys  Ala Gly Cys Thr Gly  Gly Ala Thr Gly Ala  Gly Ala Gly 
    2270                 2275                 2280             


Gly Cys  Thr Gly Ala Gly Ala  Thr Gly Gly Gly Thr  Gly Gly Cys 
    2285                 2290                 2295             


Cys Ala  Gly Cys Thr Thr Gly  Thr Ala Cys Ala Cys  Cys Ala Gly 
    2300                 2305                 2310             


Thr Cys  Cys Cys Thr Gly Ala  Ala Cys Thr Gly Ala  Gly Cys Thr 
    2315                 2320                 2325             


Gly Thr  Thr Thr Ala Cys Ala  Gly Gly Ala Cys Thr  Gly Gly Gly 
    2330                 2335                 2340             


Gly Ala  Gly Gly Cys Thr Cys  Cys Ala Cys Cys Cys  Ala Gly Ala 
    2345                 2350                 2355             


Ala Gly  Gly Cys Thr Thr Thr  Cys Ala Thr Thr Thr  Gly Thr Ala 
    2360                 2365                 2370             


Cys Thr  Cys Thr Gly Cys Thr  Gly Gly Gly Ala Gly  Thr Gly Ala 
    2375                 2380                 2385             


Cys Thr  Gly Gly Gly Ala Ala  Ala Ala Ala Cys Thr  Cys Cys Thr 
    2390                 2395                 2400             


Thr Cys  Cys Cys Thr Gly Cys  Thr Gly Cys Thr Gly  Ala Gly Thr 
    2405                 2410                 2415             


Gly Gly  Ala Gly Ala Gly Ala  Gly Gly Cys Cys Thr  Cys Ala Thr 
    2420                 2425                 2430             


Cys Cys  Gly Gly Cys Thr Thr  Thr Gly Ala Cys Cys  Cys Ala Cys 
    2435                 2440                 2445             


Cys Ala  Thr Cys Cys Gly Thr  Thr Gly Cys Ala Gly  Ala Ala Gly 
    2450                 2455                 2460             


Cys Cys  Thr Cys Cys Ala Gly  Gly Ala Gly Cys Ala  Gly Cys Ala 
    2465                 2470                 2475             


Ala Thr  Cys Cys Thr Ala Ala  Gly Ala Gly Thr Gly  Gly Gly Ala 
    2480                 2485                 2490             


Gly Gly  Cys Ala Gly Cys Cys  Ala Ala Gly Ala Cys  Cys Cys Cys 
    2495                 2500                 2505             


Cys Thr  Thr Cys Cys Thr Thr  Cys Ala Ala Ala Ala  Cys Cys Thr 
    2510                 2515                 2520             


Cys Cys  Cys Gly Gly Ala Ala  Gly Thr Gly Gly Thr  Thr Thr Cys 
    2525                 2530                 2535             


Ala Gly  Gly Cys Cys Cys Thr  Cys Thr Ala Gly Thr  Thr Gly Cys 
    2540                 2545                 2550             


Cys Ala  Thr Gly Ala Cys Cys  Ala Ala Thr Thr Thr  Gly Thr Gly 
    2555                 2560                 2565             


Thr Gly  Thr Gly Thr Gly Thr  Thr Thr Ala Ala Thr  Thr Thr Thr 
    2570                 2575                 2580             


Thr Gly  Cys Thr Thr Cys Ala  Ala Gly Cys Thr Cys  Thr Gly Thr 
    2585                 2590                 2595             


Ala Gly  Cys Ala Gly Gly Ala  Cys Cys Thr Gly Cys  Cys Cys Cys 
    2600                 2605                 2610             


Ala Cys  Gly Cys Ala Cys Ala  Cys Cys Cys Cys Thr  Ala Cys Cys 
    2615                 2620                 2625             


Cys Cys  Thr Cys Thr Gly Thr  Gly Ala Gly Gly Ala  Gly Cys Thr 
    2630                 2635                 2640             


Gly Thr  Gly Gly Gly Ala Ala  Gly Thr Gly Thr Gly  Gly Gly Thr 
    2645                 2650                 2655             


Thr Thr  Gly Thr Cys Thr Cys  Cys Ala Gly Ala Ala  Cys Ala Gly 
    2660                 2665                 2670             


Ala Ala  Gly Ala Gly Ala Ala  Thr Gly Ala Thr Gly  Gly Ala Thr 
    2675                 2680                 2685             


Ala Thr  Thr Cys Thr Gly Gly  Cys Thr Cys Thr Gly  Gly Gly Gly 
    2690                 2695                 2700             


Cys Cys  Cys Thr Cys Thr Cys  Cys Ala Cys Cys Ala  Cys Cys Ala 
    2705                 2710                 2715             


Cys Thr  Cys Ala Cys Ala Gly  Thr Ala Gly Cys Cys  Thr Thr Gly 
    2720                 2725                 2730             


Cys Thr  Gly Ala Ala Gly Cys  Cys Ala Thr Cys Ala  Cys Ala Gly 
    2735                 2740                 2745             


Ala Thr  Gly Gly Gly Ala Gly  Ala Ala Gly Gly Cys  Cys Ala Thr 
    2750                 2755                 2760             


Gly Cys  Cys Ala Gly Cys Cys  Ala Cys Gly Thr Cys  Cys Gly Cys 
    2765                 2770                 2775             


Cys Gly  Ala Gly Gly Gly Gly  Cys Gly Cys Cys Ala  Gly Cys Cys 
    2780                 2785                 2790             


Thr Gly  Ala Ala Gly Cys Thr  Gly Cys Cys Ala Gly  Gly Cys Cys 
    2795                 2800                 2805             


Cys Thr  Gly Ala Gly Gly Thr  Thr Cys Ala Gly Ala  Cys Cys Cys 
    2810                 2815                 2820             


Thr Gly  Gly Ala Cys Cys Cys  Cys Ala Thr Ala Gly  Cys Thr Gly 
    2825                 2830                 2835             


Gly Ala  Gly Gly Cys Cys Thr  Gly Thr Gly Gly Thr  Gly Cys Cys 
    2840                 2845                 2850             


Ala Gly  Ala Ala Gly Cys Cys  Cys Ala Gly Ala Thr  Thr Ala Gly 
    2855                 2860                 2865             


Gly Gly  Thr Gly Gly Cys Thr  Gly Thr Cys Cys Ala  Thr Cys Cys 
    2870                 2875                 2880             


Cys Thr  Gly Gly Ala Thr Ala  Gly Cys Thr Ala Thr  Thr Thr Gly 
    2885                 2890                 2895             


Cys Ala  Cys Gly Ala Ala Thr  Cys Ala Thr Gly Gly  Ala Cys Ala 
    2900                 2905                 2910             


Thr Ala  Ala Ala Thr Cys Cys  Ala Ala Gly Thr Thr  Gly Ala Ala 
    2915                 2920                 2925             


Gly Ala  Ala Gly Ala Thr Cys  Ala Ala Cys Ala Ala  Ala Ala Ala 
    2930                 2935                 2940             


Ala Ala  Ala Ala Ala Ala Ala  
    2945                 2950 


<210>  66
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu His Gln Phe Cys Arg Ser Arg Asn Thr Pro Gly Val Tyr Pro Val 
        595                 600                 605             


Glu Gly Phe Glu Ile Gln Ile Arg Ala Pro Lys 
    610                 615                 


<210>  67
<211>  2761
<212>  DNA
<213>  Homo sapiens

<400>  67
agtctccggg gactttccca ggggtggggc ggcccggcca ggcccccggc acttcctcgt       60

cctcggcccg ggtgccctgc ccccgtccag gagccctagg agtgctacgg ggggccggag      120

ccttgcccgg gccgctgccc cgtccctgga ttcggggctg gacgcagcaa gcggggcgct      180

gtgtccccaa gctccccgtc ctcgggggag cttttggaag agtcccagat ggaagcgacc      240

aggctccggc agaaggcaga ggagctagtg aaggacaacg agctgctccc accaccttct      300

ccctccttgg gctccttcga ccccctggct gagctcacag gaaaggactc aaatgtcaca      360

gcatctccca cagcccctgc atgccccagt gacaagccag caccagtcca gaagcctcca      420

tccagtggca cctcctctga atttgaagtg gtcactcctg aggagcagaa ttcaccagag      480

agcagcagcc atgccaatgc gatggcgctg ggccccctgc cccgtgagga cggcaacctg      540

atgctgcacc tgcagcgcct ggagaccacg ctgagtgtgt gtgccgagga gccggaccac      600

ggccagctct tcacccacct gggccgcatg gccctggagt tcaaccgact ggcatccaag      660

gtgcacaaga atgagcagcg cacctccatt ctgcagaccc tgtgtgagca gcttcggaag      720

gagaacgagg ctctgaaggc caagttggat aagggcctgg aacagcggga tcaggctgcc      780

gagaggctgc gggaggaaaa tttggagctc aagaagttgt tgatgagcaa tggcaacaaa      840

gagggtgcgt ctgggcggcc aggctcaccg aagatggaag ggacaggcaa gaaggcagtg      900

gctggacagc agcaggctag tgtgacggca ggtaaggtcc cagaggtggt ggccttgggc      960

gcagccgaga agaaggtgaa gatgctggag cagcagcgca gtgagctgct ggaagtgaac     1020

aagcagtggg accagcattt ccggtccatg aagcagcagt atgagcagaa gatcactgag     1080

ctgcgtcaga agctggctga tttgcagaag caggtgactg acctggaggc cgagcgggag     1140

cagaagcagc gtgactttga ccgcaagctc ctcctggcca agtccaagat tgaaatggag     1200

gagaccgaca aggagcagct gacagcagag gccaaggagc tgcgccaaaa ggtcaagtac     1260

ctgcaggatc agctgagccc actcacccga cagcgtgagt accaggaaaa ggagatccag     1320

cggctcaaca aggccctgga ggaagcactg agcatccaaa ccccgccatc atctccacca     1380

acagcatttg ggagcccaga aggagcaggg gccctcctaa ggaaacagga gctggtcacg     1440

cagaatgagt tgctgaaaca gcaggtgaag atcttcgagg aggacttcca gagggagcgc     1500

agtgatcgtg agcgcatgaa tgaggagaag gaagagctga agaagcaagt ggagaagctg     1560

caggcccagg tcaccctgtc aaatgcccag ctaaaagcat tcaaagatga ggagaaggca     1620

agagaagccc tcagacagca gaagaggaaa gcaaaggcct caggagagcg ttaccatgtg     1680

gagccccacc cagaacatct ctgcggggcc tacccctacg cctacccgcc catgccagcc     1740

atggtgccac accatggctt cgaggactgg tcccagatcc gctacccccc tccccccatg     1800

gccatggagc acccgccccc actccccaac tcgcgcctct tccatctgcc ggaatacacc     1860

tggcgtctac cctgtggagg ggttcgaaat ccaaatcaga gctcccaagt gatggaccct     1920

cccacagcca ggcctacaga accagagtct ccaaaaaatg accgtgaggg gcctcagtga     1980

gaccagattg tgtcatttgg ctccaccttc atcttgcaga gccagctgat ctcagattgc     2040

caagaaacta gaagccactt gcacggtgtg gccagagcct cagctggatg agaggctgag     2100

atgggtggcc agcttgtaca ccagtccctg aactgagctg tttacaggac tggggaggct     2160

ccacccagaa ggctttcatt tgtactctgc tgggagtgac tgggaaaaac tccttccctg     2220

ctgctgagtg gagagaggcc tcatccggct ttgacccacc atccgttgca gaagcctcca     2280

ggagcagcaa tcctaagagt gggaggcagc caagaccccc ttccttcaaa acctcccgga     2340

agtggtttca ggccctctag ttgccatgac caatttgtgt gtgtgtttaa tttttgcttc     2400

aagctctgta gcaggacctg ccccacgcac acccctaccc ctctgtgagg agctgtggga     2460

agtgtgggtt tgtctccaga acagaagaga atgatggata ttctggctct ggggccctct     2520

ccaccaccac tcacagtagc cttgctgaag ccatcacaga tgggagaagg ccatgccagc     2580

cacgtccgcc gaggggcgcc agcctgaagc tgccaggccc tgaggttcag accctggacc     2640

ccatagctgg aggcctgtgg tgccagaagc ccagattagg gtggctgtcc atccctggat     2700

agctatttgc acgaatcatg gacataaatc caagttgaag aagatcaaca aaaaaaaaaa     2760

a                                                                     2761


<210>  68
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu Glu Leu Val Lys Asp 
1               5                   10                  15      


Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu Gly Ser Phe Asp Pro 
            20                  25                  30          


Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val Thr Ala Ser Pro Thr 
        35                  40                  45              


Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro Val Gln Lys Pro Pro 
    50                  55                  60                  


Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val Thr Pro Glu Glu Gln 
65                  70                  75                  80  


Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala Met Ala Leu Gly Pro 
                85                  90                  95      


Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His Leu Gln Arg Leu Glu 
            100                 105                 110         


Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp His Gly Gln Leu Phe 
        115                 120                 125             


Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn Arg Leu Ala Ser Lys 
    130                 135                 140                 


Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu Gln Thr Leu Cys Glu 
145                 150                 155                 160 


Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala Lys Leu Asp Lys Gly 
                165                 170                 175     


Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu Arg Glu Glu Asn Leu 
            180                 185                 190         


Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn Lys Glu Gly Ala Ser 
        195                 200                 205             


Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr Gly Lys Lys Ala Val 
    210                 215                 220                 


Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly Lys Val Pro Glu Val 
225                 230                 235                 240 


Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys Met Leu Glu Gln Gln 
                245                 250                 255     


Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp Asp Gln His Phe Arg 
            260                 265                 270         


Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr Glu Leu Arg Gln Lys 
        275                 280                 285             


Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu Glu Ala Glu Arg Glu 
    290                 295                 300                 


Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu Leu Ala Lys Ser Lys 
305                 310                 315                 320 


Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu Thr Ala Glu Ala Lys 
                325                 330                 335     


Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp Gln Leu Ser Pro Leu 
            340                 345                 350         


Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile Gln Arg Leu Asn Lys 
        355                 360                 365             


Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro Pro Ser Ser Pro Pro 
    370                 375                 380                 


Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala Leu Leu Arg Lys Gln 
385                 390                 395                 400 


Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys Ile Phe 
                405                 410                 415     


Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met Asn Glu 
            420                 425                 430         


Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala Gln Val 
        435                 440                 445             


Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys Asp Glu Glu Lys Ala 
    450                 455                 460                 


Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala Lys Ala Ser Gly Glu 
465                 470                 475                 480 


Arg Tyr His Val Glu Pro His Pro Glu His Leu Cys Gly Ala Tyr Pro 
                485                 490                 495     


Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro His His Gly Phe Glu 
            500                 505                 510         


Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro Met Ala Met Glu His 
        515                 520                 525             


Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His Leu Pro Glu Tyr Thr 
    530                 535                 540                 


Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro Asn Gln Ser Ser Gln 
545                 550                 555                 560 


Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu Pro Glu Ser Pro Lys 
                565                 570                 575     


Asn Asp Arg Glu Gly Pro Gln 
            580             


<210>  69
<211>  2798
<212>  DNA
<213>  Homo sapiens

<400>  69
atgcaccaag gaaggagtgg gccccttctt cactatggat ggagaagcct cagagagtaa       60

gtggcaacag ccaggcgggc accacggcag gggctgagct accctcatgg aagggagagg      120

accgtaccgg atctacgacc ctgggggcag cgtgccctca ggagaggcat ccgcagcttt      180

tgagcgccta gtgaaggaga attcccggct gaaggaaaaa atgcaaggga taaagatgtt      240

aggggagctt ttggaagagt cccagatgga agcgaccagg ctccggcaga aggcagagga      300

gctagtgaag gacaacgagc tgctcccacc accttctccc tccttgggct ccttcgaccc      360

cctggctgag ctcacaggaa aggactcaaa tgtcacagca tctcccacag cccctgcatg      420

ccccagtgac aagccagcac cagtccagaa gcctccatcc agtggcacct cctctgaatt      480

tgaagtggtc actcctgagg agcagaattc accagagagc agcagccatg ccaatgcgat      540

ggcgctgggc cccctgcccc gtgaggacgg caacctgatg ctgcacctgc agcgcctgga      600

gaccacgctg agtgtgtgtg ccgaggagcc ggaccacggc cagctcttca cccacctggg      660

ccgcatggcc ctggagttca accgactggc atccaaggtg cacaagaatg agcagcgcac      720

ctccattctg cagaccctgt gtgagcagct tcggaaggag aacgaggctc tgaaggccaa      780

gttggataag ggcctggaac agcgggatca ggctgccgag aggctgcggg aggaaaattt      840

ggagctcaag aagttgttga tgagcaatgg caacaaagag ggtgcgtctg ggcggccagg      900

ctcaccgaag atggaaggga caggcaagaa ggcagtggct ggacagcagc aggctagtgt      960

gacggcaggt aaggtcccag aggtggtggc cttgggcgca gccgagaaga aggtgaagat     1020

gctggagcag cagcgcagtg agctgctgga agtgaacaag cagtgggacc agcatttccg     1080

gtccatgaag cagcagtatg agcagaagat cactgagctg cgtcagaagc tggctgattt     1140

gcagaagcag gtgactgacc tggaggccga gcgggagcag aagcagcgtg actttgaccg     1200

caagctcctc ctggccaagt ccaagattga aatggaggag accgacaagg agcagctgac     1260

agcagaggcc aaggagctgc gccaaaaggt caagtacctg caggatcagc tgagcccact     1320

cacccgacag cgtgagtacc aggaaaagga gatccagcgg ctcaacaagg ccctggagga     1380

agcactgagc atccaaaccc cgccatcatc tccaccaaca gcatttggga gcccagaagg     1440

agcaggggcc ctcctaagga aacaggagct ggtcacgcag aatgagttgc tgaaacagca     1500

ggtgaagatc ttcgaggagg acttccagag ggagcgcagt gatcgtgagc gcatgaatga     1560

ggagaaggaa gagctgaaga agcaagtgga gaagctgcag gcccaggtca ccctgtcaaa     1620

tgcccagcta aaagcattca aagatgagga gaaggcaaga gaagccctca gacagcagaa     1680

gaggaaagca aaggcctcag gagagcgtta ccatgtggag ccccacccag aacatctctg     1740

cggggcctac ccctacgcct acccgcccat gccagccatg gtgccacacc atggcttcga     1800

ggactggtcc cagatccgct acccccctcc ccccatggcc atggagcacc cgcccccact     1860

ccccaactcg cgcctcttcc atctgccgga atacacctgg cgtctaccct gtggaggggt     1920

tcgaaatcca aatcagagct cccaagtgat ggaccctccc acagccaggc ctacagaacc     1980

agagtctcca aaaaatgacc gtgaggggcc tcagtgagac cagattgtgt catttggctc     2040

caccttcatc ttgcagagcc agctgatctc agattgccaa gaaactagaa gccacttgca     2100

cggtgtggcc agagcctcag ctggatgaga ggctgagatg ggtggccagc ttgtacacca     2160

gtccctgaac tgagctgttt acaggactgg ggaggctcca cccagaaggc tttcatttgt     2220

actctgctgg gagtgactgg gaaaaactcc ttccctgctg ctgagtggag agaggcctca     2280

tccggctttg acccaccatc cgttgcagaa gcctccagga gcagcaatcc taagagtggg     2340

aggcagccaa gacccccttc cttcaaaacc tcccggaagt ggtttcaggc cctctagttg     2400

ccatgaccaa tttgtgtgtg tgtttaattt ttgcttcaag ctctgtagca ggacctgccc     2460

cacgcacacc cctacccctc tgtgaggagc tgtgggaagt gtgggtttgt ctccagaaca     2520

gaagagaatg atggatattc tggctctggg gccctctcca ccaccactca cagtagcctt     2580

gctgaagcca tcacagatgg gagaaggcca tgccagccac gtccgccgag gggcgccagc     2640

ctgaagctgc caggccctga ggttcagacc ctggacccca tagctggagg cctgtggtgc     2700

cagaagccca gattagggtg gctgtccatc cctggatagc tatttgcacg aatcatggac     2760

ataaatccaa gttgaagaag atcaacaaaa aaaaaaaa                             2798


<210>  70
<211>  2830
<212>  DNA
<213>  Homo sapiens

<400>  70
agcccagccc tccttcctgc agaagcacag tgagccgagg agccttcata gggacagccg       60

cccctggtgc acacaccctc gtattctcct gcccttcccc agccaggcgg gcaccacggc      120

aggggctgag ctaccctcat ggaagggaga ggaccgtacc ggatctacga ccctgggggc      180

agcgtgccct caggagaggc atccgcagct tttgagcgcc tagtgaagga gaattcccgg      240

ctgaaggaaa aaatgcaagg gataaagatg ttaggggagc ttttggaaga gtcccagatg      300

gaagcgacca ggctccggca gaaggcagag gagctagtga aggacaacga gctgctccca      360

ccaccttctc cctccttggg ctccttcgac cccctggctg agctcacagg aaaggactca      420

aatgtcacag catctcccac agcccctgca tgccccagtg acaagccagc accagtccag      480

aagcctccat ccagtggcac ctcctctgaa tttgaagtgg tcactcctga ggagcagaat      540

tcaccagaga gcagcagcca tgccaatgcg atggcgctgg gccccctgcc ccgtgaggac      600

ggcaacctga tgctgcacct gcagcgcctg gagaccacgc tgagtgtgtg tgccgaggag      660

ccggaccacg gccagctctt cacccacctg ggccgcatgg ccctggagtt caaccgactg      720

gcatccaagg tgcacaagaa tgagcagcgc acctccattc tgcagaccct gtgtgagcag      780

cttcggaagg agaacgaggc tctgaaggcc aagttggata agggcctgga acagcgggat      840

caggctgccg agaggctgcg ggaggaaaat ttggagctca agaagttgtt gatgagcaat      900

ggcaacaaag agggtgcgtc tgggcggcca ggctcaccga agatggaagg gacaggcaag      960

aaggcagtgg ctggacagca gcaggctagt gtgacggcag gtaaggtccc agaggtggtg     1020

gccttgggcg cagccgagaa gaaggtgaag atgctggagc agcagcgcag tgagctgctg     1080

gaagtgaaca agcagtggga ccagcatttc cggtccatga agcagcagta tgagcagaag     1140

atcactgagc tgcgtcagaa gctggctgat ttgcagaagc aggtgactga cctggaggcc     1200

gagcgggagc agaagcagcg tgactttgac cgcaagctcc tcctggccaa gtccaagatt     1260

gaaatggagg agaccgacaa ggagcagctg acagcagagg ccaaggagct gcgccaaaag     1320

gtcaagtacc tgcaggatca gctgagccca ctcacccgac agcgtgagta ccaggaaaag     1380

gagatccagc ggctcaacaa ggccctggag gaagcactga gcatccaaac cccgccatca     1440

tctccaccaa cagcatttgg gagcccagaa ggagcagggg ccctcctaag gaaacaggag     1500

ctggtcacgc agaatgagtt gctgaaacag caggtgaaga tcttcgagga ggacttccag     1560

agggagcgca gtgatcgtga gcgcatgaat gaggagaagg aagagctgaa gaagcaagtg     1620

gagaagctgc aggcccaggt caccctgtca aatgcccagc taaaagcatt caaagatgag     1680

gagaaggcaa gagaagccct cagacagcag aagaggaaag caaaggcctc aggagagcgt     1740

taccatgtgg agccccaccc agaacatctc tgcggggcct acccctacgc ctacccgccc     1800

atgccagcca tggtgccaca ccatggcttc gaggactggt cccagatccg ctacccccct     1860

ccccccatgg ccatggagca cccgccccca ctccccaact cgcgcctctt ccatctgccg     1920

gaatacacct ggcgtctacc ctgtggaggg gttcgaaatc caaatcagag ctcccaagtg     1980

atggaccctc ccacagccag gcctacagaa ccagagtctc caaaaaatga ccgtgagggg     2040

cctcagtgag accagattgt gtcatttggc tccaccttca tcttgcagag ccagctgatc     2100

tcagattgcc aagaaactag aagccacttg cacggtgtgg ccagagcctc agctggatga     2160

gaggctgaga tgggtggcca gcttgtacac cagtccctga actgagctgt ttacaggact     2220

ggggaggctc cacccagaag gctttcattt gtactctgct gggagtgact gggaaaaact     2280

ccttccctgc tgctgagtgg agagaggcct catccggctt tgacccacca tccgttgcag     2340

aagcctccag gagcagcaat cctaagagtg ggaggcagcc aagaccccct tccttcaaaa     2400

cctcccggaa gtggtttcag gccctctagt tgccatgacc aatttgtgtg tgtgtttaat     2460

ttttgcttca agctctgtag caggacctgc cccacgcaca cccctacccc tctgtgagga     2520

gctgtgggaa gtgtgggttt gtctccagaa cagaagagaa tgatggatat tctggctctg     2580

gggccctctc caccaccact cacagtagcc ttgctgaagc catcacagat gggagaaggc     2640

catgccagcc acgtccgccg aggggcgcca gcctgaagct gccaggccct gaggttcaga     2700

ccctggaccc catagctgga ggcctgtggt gccagaagcc cagattaggg tggctgtcca     2760

tccctggata gctatttgca cgaatcatgg acataaatcc aagttgaaga agatcaacaa     2820

aaaaaaaaaa                                                            2830


<210>  71
<211>  2933
<212>  DNA
<213>  Homo sapiens

<400>  71
agtctccggg gactttccca ggggtggggc ggcccggcca ggcccccggc acttcctcgt       60

cctcggcccg ggtgccctgc ccccgtccag gagccctagg agtgctacgg ggggccggag      120

ccttgcccgg gccgctgccc cgtccctgga ttcggggctg gacgcagcaa gcggggcgct      180

gtgtccccaa gctccccgtc ctcggccagg cgggcaccac ggcaggggct gagctaccct      240

catggaaggg agaggaccgt accggatcta cgaccctggg ggcagcgtgc cctcaggaga      300

ggcatccgca gcttttgagc gcctagtgaa ggagaattcc cggctgaagg aaaaaatgca      360

agggataaag atgttagggg agcttttgga agagtcccag atggaagcga ccaggctccg      420

gcagaaggca gaggagctag tgaaggacaa cgagctgctc ccaccacctt ctccctcctt      480

gggctccttc gaccccctgg ctgagctcac aggaaaggac tcaaatgtca cagcatctcc      540

cacagcccct gcatgcccca gtgacaagcc agcaccagtc cagaagcctc catccagtgg      600

cacctcctct gaatttgaag tggtcactcc tgaggagcag aattcaccag agagcagcag      660

ccatgccaat gcgatggcgc tgggccccct gccccgtgag gacggcaacc tgatgctgca      720

cctgcagcgc ctggagacca cgctgagtgt gtgtgccgag gagccggacc acggccagct      780

cttcacccac ctgggccgca tggccctgga gttcaaccga ctggcatcca aggtgcacaa      840

gaatgagcag cgcacctcca ttctgcagac cctgtgtgag cagcttcgga aggagaacga      900

ggctctgaag gccaagttgg ataagggcct ggaacagcgg gatcaggctg ccgagaggct      960

gcgggaggaa aatttggagc tcaagaagtt gttgatgagc aatggcaaca aagagggtgc     1020

gtctgggcgg ccaggctcac cgaagatgga agggacaggc aagaaggcag tggctggaca     1080

gcagcaggct agtgtgacgg caggtaaggt cccagaggtg gtggccttgg gcgcagccga     1140

gaagaaggtg aagatgctgg agcagcagcg cagtgagctg ctggaagtga acaagcagtg     1200

ggaccagcat ttccggtcca tgaagcagca gtatgagcag aagatcactg agctgcgtca     1260

gaagctggct gatttgcaga agcaggtgac tgacctggag gccgagcggg agcagaagca     1320

gcgtgacttt gaccgcaagc tcctcctggc caagtccaag attgaaatgg aggagaccga     1380

caaggagcag ctgacagcag aggccaagga gctgcgccaa aaggtcaagt acctgcagga     1440

tcagctgagc ccactcaccc gacagcgtga gtaccaggaa aaggagatcc agcggctcaa     1500

caaggccctg gaggaagcac tgagcatcca aaccccgcca tcatctccac caacagcatt     1560

tgggagccca gaaggagcag gggccctcct aaggaaacag gagctggtca cgcagaatga     1620

gttgctgaaa cagcaggtga agatcttcga ggaggacttc cagagggagc gcagtgatcg     1680

tgagcgcatg aatgaggaga aggaagagct gaagaagcaa gtggagaagc tgcaggccca     1740

ggtcaccctg tcaaatgccc agctaaaagc attcaaagat gaggagaagg caagagaagc     1800

cctcagacag cagaagagga aagcaaaggc ctcaggagag cgttaccatg tggagcccca     1860

cccagaacat ctctgcgggg cctaccccta cgcctacccg cccatgccag ccatggtgcc     1920

acaccatggc ttcgaggact ggtcccagat ccgctacccc cctcccccca tggccatgga     1980

gcacccgccc ccactcccca actcgcgcct cttccatctg ccggaataca cctggcgtct     2040

accctgtgga ggggttcgaa atccaaatca gagctcccaa gtgatggacc ctcccacagc     2100

caggcctaca gaaccagagt ctccaaaaaa tgaccgtgag gggcctcagt gagaccagat     2160

tgtgtcattt ggctccacct tcatcttgca gagccagctg atctcagatt gccaagaaac     2220

tagaagccac ttgcacggtg tggccagagc ctcagctgga tgagaggctg agatgggtgg     2280

ccagcttgta caccagtccc tgaactgagc tgtttacagg actggggagg ctccacccag     2340

aaggctttca tttgtactct gctgggagtg actgggaaaa actccttccc tgctgctgag     2400

tggagagagg cctcatccgg ctttgaccca ccatccgttg cagaagcctc caggagcagc     2460

aatcctaaga gtgggaggca gccaagaccc ccttccttca aaacctcccg gaagtggttt     2520

caggccctct agttgccatg accaatttgt gtgtgtgttt aatttttgct tcaagctctg     2580

tagcaggacc tgccccacgc acacccctac ccctctgtga ggagctgtgg gaagtgtggg     2640

tttgtctcca gaacagaaga gaatgatgga tattctggct ctggggccct ctccaccacc     2700

actcacagta gccttgctga agccatcaca gatgggagaa ggccatgcca gccacgtccg     2760

ccgaggggcg ccagcctgaa gctgccaggc cctgaggttc agaccctgga ccccatagct     2820

ggaggcctgt ggtgccagaa gcccagatta gggtggctgt ccatccctgg atagctattt     2880

gcacgaatca tggacataaa tccaagttga agaagatcaa caaaaaaaaa aaa            2933


<210>  72
<211>  2922
<212>  DNA
<213>  Homo sapiens

<400>  72
tgccagtctc cggggacttt cccaggggtg gggcggcccg gccaggcccc cggcacttcc       60

tcgtcctcgg cccgggtgcc ctgcccccgt ccaggagccc taggagtgct acggggggcc      120

ggagccttgc ccgggccgct gccccgtccc tggattcggg gctggacgca gcaagcgggg      180

cgctgtgtcc ccaagctccc cgtcctcggg cgggcaccac ggcaggggct gagctaccct      240

catggaaggg agaggaccgt accggatcta cgaccctggg ggcagcgtgc cctcaggaga      300

ggcatccgca gcttttgagc gcctagtgaa ggagaattcc cggctgaagg aaaaaatgca      360

agggataaag atgttagggg agcttttgga agagtcccag atggaagcga ccaggctccg      420

gcagaaggca gaggagctag tgaaggacaa cgagctgctc ccaccacctt ctccctcctt      480

gggctccttc gaccccctgg ctgagctcac aggaaaggac tcaaatgtca cagcatctcc      540

cacagcccct gcatgcccca gtgacaagcc agcaccagtc cagaagcctc catccagtgg      600

cacctcctct gaatttgaag tggtcactcc tgaggagcag aattcaccag agagcagcag      660

ccatgccaat gcgatggcgc tgggccccct gccccgtgag gacggcaacc tgatgctgca      720

cctgcagcgc ctggagacca cgctgagtgt gtgtgccgag gagccggacc acggccagct      780

cttcacccac ctgggccgca tggccctgga gttcaaccga ctggcatcca aggtgcacaa      840

gaatgagcag cgcacctcca ttctgcagac cctgtgtgag cagcttcgga aggagaacga      900

ggctctgaag gccaagttgg ataagggcct ggaacagcgg gatcaggctg ccgagaggct      960

gcgggaggaa aatttggagc tcaagaagtt gttgatgagc aatggcaaca aagagggtgc     1020

gtctgggcgg ccaggctcac cgaagatgga agggacaggc aagaaggcag tggctggaca     1080

gcagcaggct agtgtgacgg caggtaaggt cccagaggtg gtggccttgg gcgcagccga     1140

gaagaaggtg aagatgctgg agcagcagcg cagtgagctg ctggaagtga acaagcagtg     1200

ggaccagcat ttccggtcca tgaagcagca gtatgagcag aagatcactg agctgcgtca     1260

gaagctggct gatttgcaga agcaggtgac tgacctggag gccgagcggg agcagaagca     1320

gcgtgacttt gaccgcaagc tcctcctggc caagtccaag attgaaatgg aggagaccga     1380

caaggagcag ctgacagcag aggccaagga gctgcgccaa aaggtcaagt acctgcagga     1440

tcagctgagc ccactcaccc gacagcgtga gtaccaggaa aaggagatcc agcggctcaa     1500

caaggccctg gaggaagcac tgagcatcca aaccccgcca tcatctccac caacagcatt     1560

tgggagccca gaaggagcag gggccctcct aaggaaacag gagctggtca cgcagaatga     1620

gttgctgaaa cagcaggtga agatcttcga ggaggacttc cagagggagc gcagtgatcg     1680

tgagcgcatg aatgaggaga aggaagagct gaagaagcaa gtggagaagc tgcaggccca     1740

ggtcaccctg tcaaatgccc agctaaaagc attcaaagat gaggagaagg caagagaagc     1800

cctcagacag cagaagagga aagcaaaggc ctcaggagag cgttaccatg tggagcccca     1860

cccagaacat ctctgcgggg cctaccccta cgcctacccg cccatgccag ccatggtgcc     1920

acaccatggc ttcgaggact ggtcccagat ccgctacccc cctcccccca tggccatgga     1980

gcacccgccc ccactcccca actcgcgcct cttccatctg ccggaataca cctggcgtct     2040

accctgtgga ggggttcgaa atccaaatca gagctcccaa gtgatggacc ctcccacagc     2100

caggcctaca gaaccagagt ctccaaaaaa tgaccgtgag gggcctcagt gagaccagat     2160

tgtgtcattt ggctccacct tcatcttgca gagccagctg atctcagatt gccaagaaac     2220

tagaagccac ttgcacggtg tggccagagc ctcagctgga tgagaggctg agatgggtgg     2280

ccagcttgta caccagtccc tgaactgagc tgtttacagg actggggagg ctccacccag     2340

aaggctttca tttgtactct gctgggagtg actgggaaaa actccttccc tgctgctgag     2400

tggagagagg cctcatccgg ctttgaccca ccatccgttg cagaagcctc caggagcagc     2460

aatcctaaga gtgggaggca gccaagaccc ccttccttca aaacctcccg gaagtggttt     2520

caggccctct agttgccatg accaatttgt gtgtgtgttt aatttttgct tcaagctctg     2580

tagcaggacc tgccccacgc acacccctac ccctctgtga ggagctgtgg gaagtgtggg     2640

tttgtctcca gaacagaaga gaatgatgga tattctggct ctggggccct ctccaccacc     2700

actcacagta gccttgctga agccatcaca gatgggagaa ggccatgcca gccacgtccg     2760

ccgaggggcg ccagcctgaa gctgccaggc cctgaggttc agaccctgga ccccatagct     2820

ggaggcctgt ggtgccagaa gcccagatta gggtggctgt ccatccctgg atagctattt     2880

gcacgaatca tggacataaa tccaagttga agaagatcaa ca                        2922


<210>  73
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
        595                 600                 605             


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
    610                 615                 620                 


Pro Glu Ser Pro Lys Asn Asp Arg Glu Gly Pro Gln 
625                 630                 635     


<210>  74
<211>  2756
<212>  DNA
<213>  Homo sapiens

<400>  74
agcccagccc tccttcctgc agaagcacag tgagccgagg agccttcata gggacagccg       60

cccctggtgc acacaccctc gtattctcct gcccttcccc agccaggcgg gcaccacggc      120

aggggctgag ctaccctcat ggaagggaga ggaccgtacc ggatctacga ccctgggggc      180

agcgtgccct caggagaggc atccgcagct tttgagcgcc tagtgaagga gaattcccgg      240

ctgaaggaaa aaatgcaagg gataaagatg ttaggggagc ttttggaaga gtcccagatg      300

gaagcgacca ggctccggca gaaggcagag gagctagtga aggacaacga gctgctccca      360

ccaccttctc cctccttggg ctccttcgac cccctggctg agctcacagg aaaggactca      420

aatgtcacag catctcccac agcccctgca tgccccagtg acaagccagc accagtccag      480

aagcctccat ccagtggcac ctcctctgaa tttgaagtgg tcactcctga ggagcagaat      540

tcaccagaga gcagcagcca tgccaatgcg atggcgctgg gccccctgcc ccgtgaggac      600

ggcaacctga tgctgcacct gcagcgcctg gagaccacgc tgagtgtgtg tgccgaggag      660

ccggaccacg gccagctctt cacccacctg ggccgcatgg ccctggagtt caaccgactg      720

gcatccaagg tgcacaagaa tgagcagcgc acctccattc tgcagaccct gtgtgagcag      780

cttcggaagg agaacgaggc tctgaaggcc aagttggata agggcctgga acagcgggat      840

caggctgccg agaggctgcg ggaggaaaat ttggagctca agaagttgtt gatgagcaat      900

ggcaacaaag agggtgcgtc tgggcggcca ggctcaccga agatggaagg gacaggcaag      960

aaggcagtgg ctggacagca gcaggctagt gtgacggcag gtaaggtccc agaggtggtg     1020

gccttgggcg cagccgagaa gaaggtgaag atgctggagc agcagcgcag tgagctgctg     1080

gaagtgaaca agcagtggga ccagcatttc cggtccatga agcagcagta tgagcagaag     1140

atcactgagc tgcgtcagaa gctggctgat ttgcagaagc aggtgactga cctggaggcc     1200

gagcgggagc agaagcagcg tgactttgac cgcaagctcc tcctggccaa gtccaagatt     1260

gaaatggagg agaccgacaa ggagcagctg acagcagagg ccaaggagct gcgccaaaag     1320

gtcaagtacc tgcaggatca gctgagccca ctcacccgac agcgtgagta ccaggaaaag     1380

gagatccagc ggctcaacaa ggccctggag gaagcactga gcatccaaac cccgccatca     1440

tctccaccaa cagcatttgg gagcccagaa ggagcagggg ccctcctaag gaaacaggag     1500

ctggtcacgc agaatgagtt gctgaaacag caggtgaaga tcttcgagga ggacttccag     1560

agggagcgca gtgatcgtga gcgcatgaat gaggagaagg aagagctgaa gaagcaagtg     1620

gagaagctgc aggcccaggt caccctgtca aatgcccagc taaaagcatt caaagatgag     1680

gagaaggcaa gagaagccct cagacagcag aagaggaaag caaaggcctc aggagagcgt     1740

taccatgtgg agccccaccc agaacatctc tgcggggcct acccctacgc ctacccgccc     1800

atgccagcca tggtgccaca ccatggcttc gaggactggt cccagatccg ctacccccct     1860

ccccccatgg ccatggagca cccgccccca ctccccaact cgcgcctctt ccatctgccg     1920

gaatacacct ggcgtctacc ctgtggaggg gttcgaaatc caaatcagag ctcccaagtg     1980

atggaccctc ccacagccag gcctacagaa ccagagccag ctgatctcag attgccaaga     2040

aactagaagc cacttgcacg gtgtggccag agcctcagct ggatgagagg ctgagatggg     2100

tggccagctt gtacaccagt ccctgaactg agctgtttac aggactgggg aggctccacc     2160

cagaaggctt tcatttgtac tctgctggga gtgactggga aaaactcctt ccctgctgct     2220

gagtggagag aggcctcatc cggctttgac ccaccatccg ttgcagaagc ctccaggagc     2280

agcaatccta agagtgggag gcagccaaga cccccttcct tcaaaacctc ccggaagtgg     2340

tttcaggccc tctagttgcc atgaccaatt tgtgtgtgtg tttaattttt gcttcaagct     2400

ctgtagcagg acctgcccca cgcacacccc tacccctctg tgaggagctg tgggaagtgt     2460

gggtttgtct ccagaacaga agagaatgat ggatattctg gctctggggc cctctccacc     2520

accactcaca gtagccttgc tgaagccatc acagatggga gaaggccatg ccagccacgt     2580

ccgccgaggg gcgccagcct gaagctgcca ggccctgagg ttcagaccct ggaccccata     2640

gctggaggcc tgtggtgcca gaagcccaga ttagggtggc tgtccatccc tggatagcta     2700

tttgcacgaa tcatggacat aaatccaagt tgaagaagat caacaaaaaa aaaaaa         2756


<210>  75
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  75
agtctccggg gactttccca ggggtggggc ggcccggcca ggcccccggc acttcctcgt       60

cctcggcccg ggtgccctgc ccccgtccag gagccctagg agtgctacgg ggggccggag      120

ccttgcccgg gccgctgccc cgtccctgga ttcggggctg gacgcagcaa gcggggcgct      180

gtgtccccaa gctccccgtc ctcggccagg cgggcaccac ggcaggggct gagctaccct      240

catggaaggg agaggaccgt accggatcta cgaccctggg ggcagcgtgc cctcaggaga      300

ggcatccgca gcttttgagc gcctagtgaa ggagaattcc cggctgaagg aaaaaatgca      360

agggataaag atgttagggg agcttttgga agagtcccag atggaagcga ccaggctccg      420

gcagaaggca gaggagctag tgaaggacaa cgagctgctc ccaccacctt ctccctcctt      480

gggctccttc gaccccctgg ctgagctcac aggaaaggac tcaaatgtca cagcatctcc      540

cacagcccct gcatgcccca gtgacaagcc agcaccagtc cagaagcctc catccagtgg      600

cacctcctct gaatttgaag tggtcactcc tgaggagcag aattcaccag agagcagcag      660

ccatgccaat gcgatggcgc tgggccccct gccccgtgag gacggcaacc tgatgctgca      720

cctgcagcgc ctggagacca cgctgagtgt gtgtgccgag gagccggacc acggccagct      780

cttcacccac ctgggccgca tggccctgga gttcaaccga ctggcatcca aggtgcacaa      840

gaatgagcag cgcacctcca ttctgcagac cctgtgtgag cagcttcgga aggagaacga      900

ggctctgaag gccaagttgg ataagggcct ggaacagcgg gatcaggctg ccgagaggct      960

gcgggaggaa aatttggagc tcaagaagtt gttgatgagc aatggcaaca aagagggtgc     1020

gtctgggcgg ccaggctcac cgaagatgga agggacaggc aagaaggcag tggctggaca     1080

gcagcaggct agtgtgacgg caggtaaggt cccagaggtg gtggccttgg gcgcagccga     1140

gaagaaggtg aagatgctgg agcagcagcg cagtgagctg ctggaagtga acaagcagtg     1200

ggaccagcat ttccggtcca tgaagcagca gtatgagcag aagatcactg agctgcgtca     1260

gaagctggct gatttgcaga agcaggtgac tgacctggag gccgagcggg agcagaagca     1320

gcgtgacttt gaccgcaagc tcctcctggc caagtccaag attgaaatgg aggagaccga     1380

caaggagcag ctgacagcag aggccaagga gctgcgccaa aaggtcaagt acctgcagga     1440

tcagctgagc ccactcaccc gacagcgtga gtaccaggaa aaggagatcc agcggctcaa     1500

caaggccctg gaggaagcac tgagcatcca aaccccgcca tcatctccac caacagcatt     1560

tgggagccca gaaggagcag gggccctcct aaggaaacag gagctggtca cgcagaatga     1620

gttgctgaaa cagcaggtga agatcttcga ggaggacttc cagagggagc gcagtgatcg     1680

tgagcgcatg aatgaggaga aggaagagct gaagaagcaa gtggagaagc tgcaggccca     1740

ggtcaccctg tcaaatgccc agctaaaagc attcaaagat gaggagaagg caagagaagc     1800

cctcagacag cagaagagga aagcaaaggc ctcaggagag cgttaccatg tggagcccca     1860

cccagaacat ctctgcgggg cctaccccta cgcctacccg cccatgccag ccatggtgcc     1920

acaccatggc ttcgaggact ggtcccagat ccgctacccc cctcccccca tggccatgga     1980

gcacccgccc ccactcccca actcgcgcct cttccatctg ccggaataca cctggcgtct     2040

accctgtgga ggggttcgaa atccaaatca gagctcccaa gtgatggacc ctcccacagc     2100

caggcctaca gaaccagagc cagctgatct cagattgcca agaaactaga agccacttgc     2160

acggtgtggc cagagcctca gctggatgag aggctgagat gggtggccag cttgtacacc     2220

agtccctgaa ctgagctgtt tacaggactg gggaggctcc acccagaagg ctttcatttg     2280

tactctgctg ggagtgactg ggaaaaactc cttccctgct gctgagtgga gagaggcctc     2340

atccggcttt gacccaccat ccgttgcaga agcctccagg agcagcaatc ctaagagtgg     2400

gaggcagcca agaccccctt ccttcaaaac ctcccggaag tggtttcagg ccctctagtt     2460

gccatgacca atttgtgtgt gtgtttaatt tttgcttcaa gctctgtagc aggacctgcc     2520

ccacgcacac ccctacccct ctgtgaggag ctgtgggaag tgtgggtttg tctccagaac     2580

agaagagaat gatggatatt ctggctctgg ggccctctcc accaccactc acagtagcct     2640

tgctgaagcc atcacagatg ggagaaggcc atgccagcca cgtccgccga ggggcgccag     2700

cctgaagctg ccaggccctg aggttcagac cctggacccc atagctggag gcctgtggtg     2760

ccagaagccc agattagggt ggctgtccat ccctggatag ctatttgcac gaatcatgga     2820

cataaatcca agttgaagaa gatcaacaaa aaaaaaaaa                            2859


<210>  76
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ala Ser Gly Glu Arg Tyr His Val Glu Pro His Pro Glu His Leu 
    530                 535                 540                 


Cys Gly Ala Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro 
545                 550                 555                 560 


His His Gly Phe Glu Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro 
                565                 570                 575     


Met Ala Met Glu His Pro Pro Pro Leu Pro Asn Ser Arg Leu Phe His 
            580                 585                 590         


Leu Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
        595                 600                 605             


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
    610                 615                 620                 


Pro Glu Pro Ala Asp Leu Arg Leu Pro Arg Asn 
625                 630                 635 


<210>  77
<211>  2525
<212>  DNA
<213>  Homo sapiens

<400>  77
ccaggcgggc accacggcag gggctgagct accctcatgg aagggagagg accgtaccgg       60

atctacgacc ctgggggcag cgtgccctca ggagaggcat ccgcagcttt tgagcgccta      120

gtgaaggaga attcccggct gaaggaaaaa atgcaaggga taaagatgtt aggggagctt      180

ttggaagagt cccagatgga agcgaccagg ctccggcaga aggcagagga gctagtgaag      240

gacaacgagc tgctcccacc accttctccc tccttgggct ccttcgaccc cctggctgag      300

ctcacaggaa aggactcaaa tgtcacagca tctcccacag cccctgcatg ccccagtgac      360

aagccagcac cagtccagaa gcctccatcc agtggcacct cctctgaatt tgaagtggtc      420

actcctgagg agcagaattc accagagagc agcagccatg ccaatgcgat ggcgctgggc      480

cccctgcccc gtgaggacgg caacctgatg ctgcacctgc agcgcctgga gaccacgctg      540

agtgtgtgtg ccgaggagcc ggaccacggc cagctcttca cccacctggg ccgcatggcc      600

ctggagttca accgactggc atccaaggtg cacaagaatg agcagcgcac ctccattctg      660

cagaccctgt gtgagcagct tcggaaggag aacgaggctc tgaaggccaa gttggataag      720

ggcctggaac agcgggatca ggctgccgag aggctgcggg aggaaaattt ggagctcaag      780

aagttgttga tgagcaatgg caacaaagag ggtgcgtctg ggcggccagg ctcaccgaag      840

atggaaggga caggcaagaa ggcagtggct ggacagcagc aggctagtgt gacggcaggt      900

aaggtcccag aggtggtggc cttgggcgca gccgagaaga aggtgaagat gctggagcag      960

cagcgcagtg agctgctgga agtgaacaag cagtgggacc agcatttccg gtccatgaag     1020

cagcagtatg agcagaagat cactgagctg cgtcagaagc tggctgattt gcagaagcag     1080

gtgactgacc tggaggccga gcgggagcag aagcagcgtg actttgaccg caagctcctc     1140

ctggccaagt ccaagattga aatggaggag accgacaagg agcagctgac agcagaggcc     1200

aaggagctgc gccaaaaggt caagtacctg caggatcagc tgagcccact cacccgacag     1260

cgtgagtacc aggaaaagga gatccagcgg ctcaacaagg ccctggagga agcactgagc     1320

atccaaaccc cgccatcatc tccaccaaca gcatttggga gcccagaagg agcaggggcc     1380

ctcctaagga aacaggagct ggtcacgcag aatgagttgc tgaaacagca ggtgaagatc     1440

ttcgaggagg acttccagag ggagcgcagt gatcgtgagc gcatgaatga ggagaaggaa     1500

gagctgaaga agcaagtgga gaagctgcag gcccaggtca ccctgtcaaa tgcccagcta     1560

aaagcattca aagatgagga gaaggcaaga gaagccctca gacagcagaa gaggaaagca     1620

aagccggaat acacctggcg tctaccctgt ggaggggttc gaaatccaaa tcagagctcc     1680

caagtgatgg accctcccac agccaggcct acagaaccag agtctccaaa aaatgaccgt     1740

gaggggcctc agtgagacca gattgtgtca tttggctcca ccttcatctt gcagagccag     1800

ctgatctcag attgccaaga aactagaagc cacttgcacg gtgtggccag agcctcagct     1860

ggatgagagg ctgagatggg tggccagctt gtacaccagt ccctgaactg agctgtttac     1920

aggactgggg aggctccacc cagaaggctt tcatttgtac tctgctggga gtgactggga     1980

aaaactcctt ccctgctgct gagtggagag aggcctcatc cggctttgac ccaccatccg     2040

ttgcagaagc ctccaggagc agcaatccta agagtgggag gcagccaaga cccccttcct     2100

tcaaaacctc ccggaagtgg tttcaggccc tctagttgcc atgaccaatt tgtgtgtgtg     2160

tttaattttt gcttcaagct ctgtagcagg acctgcccca cgcacacccc tacccctctg     2220

tgaggagctg tgggaagtgt gggtttgtct ccagaacaga agagaatgat ggatattctg     2280

gctctggggc cctctccacc accactcaca gtagccttgc tgaagccatc acagatggga     2340

gaaggccatg ccagccacgt ccgccgaggg gcgccagcct gaagctgcca ggccctgagg     2400

ttcagaccct ggaccccata gctggaggcc tgtggtgcca gaagcccaga ttagggtggc     2460

tgtccatccc tggatagcta tttgcacgaa tcatggacat aaatccaagt tgaagaagat     2520

caaca                                                                 2525


<210>  78
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Pro Glu Tyr Thr Trp Arg Leu Pro Cys Gly Gly Val Arg Asn Pro 
    530                 535                 540                 


Asn Gln Ser Ser Gln Val Met Asp Pro Pro Thr Ala Arg Pro Thr Glu 
545                 550                 555                 560 


Pro Glu Ser Pro Lys Asn Asp Arg Glu Gly Pro Gln 
                565                 570         


<210>  79
<211>  2428
<212>  DNA
<213>  Homo sapiens

<400>  79
ccaggcgggc accacggcag gggctgagct accctcatgg aagggagagg accgtaccgg       60

atctacgacc ctgggggcag cgtgccctca ggagaggcat ccgcagcttt tgagcgccta      120

gtgaaggaga attcccggct gaaggaaaaa atgcaaggga taaagatgtt aggggagctt      180

ttggaagagt cccagatgga agcgaccagg ctccggcaga aggcagagga gctagtgaag      240

gacaacgagc tgctcccacc accttctccc tccttgggct ccttcgaccc cctggctgag      300

ctcacaggaa aggactcaaa tgtcacagca tctcccacag cccctgcatg ccccagtgac      360

aagccagcac cagtccagaa gcctccatcc agtggcacct cctctgaatt tgaagtggtc      420

actcctgagg agcagaattc accagagagc agcagccatg ccaatgcgat ggcgctgggc      480

cccctgcccc gtgaggacgg caacctgatg ctgcacctgc agcgcctgga gaccacgctg      540

agtgtgtgtg ccgaggagcc ggaccacggc cagctcttca cccacctggg ccgcatggcc      600

ctggagttca accgactggc atccaaggtg cacaagaatg agcagcgcac ctccattctg      660

cagaccctgt gtgagcagct tcggaaggag aacgaggctc tgaaggccaa gttggataag      720

ggcctggaac agcgggatca ggctgccgag aggctgcggg aggaaaattt ggagctcaag      780

aagttgttga tgagcaatgg caacaaagag ggtgcgtctg ggcggccagg ctcaccgaag      840

atggaaggga caggcaagaa ggcagtggct ggacagcagc aggctagtgt gacggcaggt      900

aaggtcccag aggtggtggc cttgggcgca gccgagaaga aggtgaagat gctggagcag      960

cagcgcagtg agctgctgga agtgaacaag cagtgggacc agcatttccg gtccatgaag     1020

cagcagtatg agcagaagat cactgagctg cgtcagaagc tggctgattt gcagaagcag     1080

gtgactgacc tggaggccga gcgggagcag aagcagcgtg actttgaccg caagctcctc     1140

ctggccaagt ccaagattga aatggaggag accgacaagg agcagctgac agcagaggcc     1200

aaggagctgc gccaaaaggt caagtacctg caggatcagc tgagcccact cacccgacag     1260

cgtgagtacc aggaaaagga gatccagcgg ctcaacaagg ccctggagga agcactgagc     1320

atccaaaccc cgccatcatc tccaccaaca gcatttggga gcccagaagg agcaggggcc     1380

ctcctaagga aacaggagct ggtcacgcag aatgagttgc tgaaacagca ggtgaagatc     1440

ttcgaggagg acttccagag ggagcgcagt gatcgtgagc gcatgaatga ggagaaggaa     1500

gagctgaaga agcaagtgga gaagctgcag gcccaggtca ccctgtcaaa tgcccagcta     1560

aaagcattca aagatgagga gaaggcaaga gaagccctca gacagcagaa gaggaaagca     1620

aagagtctcc aaaaaatgac cgtgaggggc ctcagtgaga ccagattgtg tcatttggct     1680

ccaccttcat cttgcagagc cagctgatct cagattgcca agaaactaga agccacttgc     1740

acggtgtggc cagagcctca gctggatgag aggctgagat gggtggccag cttgtacacc     1800

agtccctgaa ctgagctgtt tacaggactg gggaggctcc acccagaagg ctttcatttg     1860

tactctgctg ggagtgactg ggaaaaactc cttccctgct gctgagtgga gagaggcctc     1920

atccggcttt gacccaccat ccgttgcaga agcctccagg agcagcaatc ctaagagtgg     1980

gaggcagcca agaccccctt ccttcaaaac ctcccggaag tggtttcagg ccctctagtt     2040

gccatgacca atttgtgtgt gtgtttaatt tttgcttcaa gctctgtagc aggacctgcc     2100

ccacgcacac ccctacccct ctgtgaggag ctgtgggaag tgtgggtttg tctccagaac     2160

agaagagaat gatggatatt ctggctctgg ggccctctcc accaccactc acagtagcct     2220

tgctgaagcc atcacagatg ggagaaggcc atgccagcca cgtccgccga ggggcgccag     2280

cctgaagctg ccaggccctg aggttcagac cctggacccc atagctggag gcctgtggtg     2340

ccagaagccc agattagggt ggctgtccat ccctggatag ctatttgcac gaatcatgga     2400

cataaatcca agttgaagaa gatcaaca                                        2428


<210>  80
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Gly Arg Gly Pro Tyr Arg Ile Tyr Asp Pro Gly Gly Ser Val 
1               5                   10                  15      


Pro Ser Gly Glu Ala Ser Ala Ala Phe Glu Arg Leu Val Lys Glu Asn 
            20                  25                  30          


Ser Arg Leu Lys Glu Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Thr Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Asn Glu Leu Leu Pro Pro Pro Ser Pro Ser Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Pro Leu Ala Glu Leu Thr Gly Lys Asp Ser Asn Val 
                85                  90                  95      


Thr Ala Ser Pro Thr Ala Pro Ala Cys Pro Ser Asp Lys Pro Ala Pro 
            100                 105                 110         


Val Gln Lys Pro Pro Ser Ser Gly Thr Ser Ser Glu Phe Glu Val Val 
        115                 120                 125             


Thr Pro Glu Glu Gln Asn Ser Pro Glu Ser Ser Ser His Ala Asn Ala 
    130                 135                 140                 


Met Ala Leu Gly Pro Leu Pro Arg Glu Asp Gly Asn Leu Met Leu His 
145                 150                 155                 160 


Leu Gln Arg Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp 
                165                 170                 175     


His Gly Gln Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn 
            180                 185                 190         


Arg Leu Ala Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu 
        195                 200                 205             


Gln Thr Leu Cys Glu Gln Leu Arg Lys Glu Asn Glu Ala Leu Lys Ala 
    210                 215                 220                 


Lys Leu Asp Lys Gly Leu Glu Gln Arg Asp Gln Ala Ala Glu Arg Leu 
225                 230                 235                 240 


Arg Glu Glu Asn Leu Glu Leu Lys Lys Leu Leu Met Ser Asn Gly Asn 
                245                 250                 255     


Lys Glu Gly Ala Ser Gly Arg Pro Gly Ser Pro Lys Met Glu Gly Thr 
            260                 265                 270         


Gly Lys Lys Ala Val Ala Gly Gln Gln Gln Ala Ser Val Thr Ala Gly 
        275                 280                 285             


Lys Val Pro Glu Val Val Ala Leu Gly Ala Ala Glu Lys Lys Val Lys 
    290                 295                 300                 


Met Leu Glu Gln Gln Arg Ser Glu Leu Leu Glu Val Asn Lys Gln Trp 
305                 310                 315                 320 


Asp Gln His Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr 
                325                 330                 335     


Glu Leu Arg Gln Lys Leu Ala Asp Leu Gln Lys Gln Val Thr Asp Leu 
            340                 345                 350         


Glu Ala Glu Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu 
        355                 360                 365             


Leu Ala Lys Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu 
    370                 375                 380                 


Thr Ala Glu Ala Lys Glu Leu Arg Gln Lys Val Lys Tyr Leu Gln Asp 
385                 390                 395                 400 


Gln Leu Ser Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile 
                405                 410                 415     


Gln Arg Leu Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Thr Pro 
            420                 425                 430         


Pro Ser Ser Pro Pro Thr Ala Phe Gly Ser Pro Glu Gly Ala Gly Ala 
        435                 440                 445             


Leu Leu Arg Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln 
    450                 455                 460                 


Gln Val Lys Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg 
465                 470                 475                 480 


Glu Arg Met Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys 
                485                 490                 495     


Leu Gln Ala Gln Val Thr Leu Ser Asn Ala Gln Leu Lys Ala Phe Lys 
            500                 505                 510         


Asp Glu Glu Lys Ala Arg Glu Ala Leu Arg Gln Gln Lys Arg Lys Ala 
        515                 520                 525             


Lys Ser Leu Gln Lys Met Thr Val Arg Gly Leu Ser Glu Thr Arg Leu 
    530                 535                 540                 


Cys His Leu Ala Pro Pro Ser Ser Cys Arg Ala Ser 
545                 550                 555     


<210>  81
<211>  2838
<212>  DNA
<213>  Mus musculus

<400>  81
tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac       60

atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaagct aggcggccgt      120

cacggcaggg gttgagccac cctcatggaa gggagaggac cctacgggat ctacgaccca      180

gggggcagca cgcctctggg agaggtgtcc gcagcttttg aacgtctagt ggaggagaat      240

actcggctga agggaaaaat gcaagggata aagatgttag gggagcttct ggaggagtct      300

cagatggaag cgtccagact ccggcagaag gcagaggagc tggtcaagga cagcgagctg      360

tcaccaccga catctgcccc ctccttggtc tcctttgatg acctggctga gctcacagga      420

caggatacaa aggtccaggt acatcctgct accagcactg ccgccaccac caccgccacc      480

gccaccacgg gaaactccat ggagaagccc gagccagcct ccaaatctcc gtccaatggc      540

gcctcctcgg actttgaagt ggtccctact gaggagcaga attcacccga aactggcagc      600

caccctacga acatgatgga cctggggccc ccacccccag aggacagcaa cctgaagctc      660

cacctgcagc gcctggagac cacccttagc gtgtgtgcag aggagccaga ccacagccag      720

ctcttcaccc acctgggccg catggccctc gagttcaaca ggttggcctc caaagtgcat      780

aaaaatgagc agcgcacctc catcctgcag accttatgtg agcagctgcg ccaggagaat      840

gaagccctga aggccaagct ggacaagggc ctggaacagc gggatctggc tgctgagagg      900

ctgcgggagg aaaacacgga gctcaagaaa ctgttgatga acagcagctg caaagaggga      960

ctctgtgggc agcccagctc cccaaagcca gagggtgctg gcaagaaggg cgtggctgga     1020

cagcagcagg ccagtgtgat ggcgagtaaa gtccctgaag cgggggcctt tggagcagct     1080

gagaagaagg tgaagttgct agaacagcaa cgcatggagc tgctggaagt gaacaagcag     1140

tgggaccagc atttccggtc catgaagcag cagtatgagc agaagatcac agagcttcgc     1200

cagaagctgg tggacctgca gaaacaggta actgagctgg aggccgaacg ggagcagaag     1260

cagcgtgact ttgaccggaa actcctcctg gccaaatcga agatagagat ggaagagacc     1320

gacaaggagc agctgacagc agaggccaag gaactgcgcc agaaggtcag gtacctacag     1380

gatcagctga gcccgctcac aaggcaacga gaataccagg agaaggagat ccagcggctc     1440

aataaggccc tggaggaggc cctcagcatc caggcctctc catcatctcc gcctgcagct     1500

tttgggagtc cagaaggcgt tgggggccat ctgaggaagc aggaactagt gacacagaat     1560

gagttgctga aacagcaggt aaagatcttt gaagaggact tccagaggga acggagtgac     1620

cgtgaacgca tgaatgaaga gaaggaggag ctgaagaagc aagtagagaa gctgcaggcc     1680

caggtcaccc tgactaatgc ccagctcaaa actctcaaag aggaggagaa ggccaaggaa     1740

gccctcaaac agcagaagag gaaagcaaag gcttcgggag agcgctacca catggaaccc     1800

caccctgagc acgtctgcgg cgcctatccc tatgcctacc cacccatgcc agccatggta     1860

cctcaccatg cctacaagga ctggtcccag atccgatacc ctccaccccc tgtgcccatg     1920

gagcacccgc ccccacaccc caactctcgc ctcttccatc tgccggagta cacctggcgt     1980

ccaccctgtg cagggattcg gaatcagagc tctcaagtga tggacccgcc cccagacagg     2040

cctgcagagc cagagtctgc agacaatgac tgtgatgggc cccagtgagg ctgcagtggg     2100

tcatttggtt ccaccttcat ctttcagagc cagctgacct cagattgcca aaagtttgaa     2160

ggccatgtgc atgttctgtg tgacccaagc cttggcagag gagaggctgg gatgggtagc     2220

tggctcacat ccccagccaa gcctcgaact gttgacaaga ccagggagaa tccacccatg     2280

ggcgcccacc aggttcttat ggatgcaagc aggagaagct caacaccctg cctcttgcca     2340

agacaaggaa gcctcacctg gctttgacct gccatccgtt gctgaggcca ctggcttcca     2400

tcctaagaat gaggtgcaac aagaccccat tctcacagaa cctcaaagac ttggttccag     2460

gctctccaga gaccataccc aactcatgtg catgtgccgt ttttgcttca agctcagtag     2520

caggacctgc cccgagcccc ctgctccttg cccctctgtg aggagttacg gagagggctt     2580

tgtctctaga gcagaagaga atgatgggac ggcctgatgc tgtcatgctc tccactgcac     2640

ctgtggcagc ctcctgagag ccaccaagat ctgggatgaa ggccacacca gccatgtctg     2700

ctgaagggcc ccagactgag atgactccgg cctccacagt tagatgttta tggtgccaga     2760

ggtctatatt aaggtagctg tctgttgcta ggcagccgtt tgcacaaatc ttggacataa     2820

atccaacttg aagatcaa                                                   2838


<210>  82
<211>  2996
<212>  DNA
<213>  Mus musculus

<400>  82
tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac       60

atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaagac cccgccccgg      120

cgcccagcgc gcaacgccat tggacagacc gtacatcggt ctccggggac tttcccaggg      180

gcgtggcgtg gccctggcat ttcctggtac cgaccggagc ttagattctg cgagtctggc      240

cccggccccg aagctctcgt cctaggctag gcggccgtca cggcaggggt tgagccaccc      300

tcatggaagg gagaggaccc tacgggatct acgacccagg gggcagcacg cctctgggag      360

aggtgtccgc agcttttgaa cgtctagtgg aggagaatac tcggctgaag ggaaaaatgc      420

aagggataaa gatgttaggg gagcttctgg aggagtctca gatggaagcg tccagactcc      480

ggcagaaggc agaggagctg gtcaaggaca gcgagctgtc accaccgaca tctgccccct      540

ccttggtctc ctttgatgac ctggctgagc tcacaggaca ggatacaaag gtccaggtac      600

atcctgctac cagcactgcc gccaccacca ccgccaccgc caccacggga aactccatgg      660

agaagcccga gccagcctcc aaatctccgt ccaatggcgc ctcctcggac tttgaagtgg      720

tccctactga ggagcagaat tcacccgaaa ctggcagcca ccctacgaac atgatggacc      780

tggggccccc acccccagag gacagcaacc tgaagctcca cctgcagcgc ctggagacca      840

cccttagcgt gtgtgcagag gagccagacc acagccagct cttcacccac ctgggccgca      900

tggccctcga gttcaacagg ttggcctcca aagtgcataa aaatgagcag cgcacctcca      960

tcctgcagac cttatgtgag cagctgcgcc aggagaatga agccctgaag gccaagctgg     1020

acaagggcct ggaacagcgg gatctggctg ctgagaggct gcgggaggaa aacacggagc     1080

tcaagaaact gttgatgaac agcagctgca aagagggact ctgtgggcag cccagctccc     1140

caaagccaga gggtgctggc aagaagggcg tggctggaca gcagcaggcc agtgtgatgg     1200

cgagtaaagt ccctgaagcg ggggcctttg gagcagctga gaagaaggtg aagttgctag     1260

aacagcaacg catggagctg ctggaagtga acaagcagtg ggaccagcat ttccggtcca     1320

tgaagcagca gtatgagcag aagatcacag agcttcgcca gaagctggtg gacctgcaga     1380

aacaggtaac tgagctggag gccgaacggg agcagaagca gcgtgacttt gaccggaaac     1440

tcctcctggc caaatcgaag atagagatgg aagagaccga caaggagcag ctgacagcag     1500

aggccaagga actgcgccag aaggtcaggt acctacagga tcagctgagc ccgctcacaa     1560

ggcaacgaga ataccaggag aaggagatcc agcggctcaa taaggccctg gaggaggccc     1620

tcagcatcca ggcctctcca tcatctccgc ctgcagcttt tgggagtcca gaaggcgttg     1680

ggggccatct gaggaagcag gaactagtga cacagaatga gttgctgaaa cagcaggtaa     1740

agatctttga agaggacttc cagagggaac ggagtgaccg tgaacgcatg aatgaagaga     1800

aggaggagct gaagaagcaa gtagagaagc tgcaggccca ggtcaccctg actaatgccc     1860

agctcaaaac tctcaaagag gaggagaagg ccaaggaagc cctcaaacag cagaagagga     1920

aagcaaaggc ttcgggagag cgctaccaca tggaacccca ccctgagcac gtctgcggcg     1980

cctatcccta tgcctaccca cccatgccag ccatggtacc tcaccatgcc tacaaggact     2040

ggtcccagat ccgataccct ccaccccctg tgcccatgga gcacccgccc ccacacccca     2100

actctcgcct cttccatctg ccggagtaca cctggcgtcc accctgtgca gggattcgga     2160

atcagagctc tcaagtgatg gacccgcccc cagacaggcc tgcagagcca gagtctgcag     2220

acaatgactg tgatgggccc cagtgaggct gcagtgggtc atttggttcc accttcatct     2280

ttcagagcca gctgacctca gattgccaaa agtttgaagg ccatgtgcat gttctgtgtg     2340

acccaagcct tggcagagga gaggctggga tgggtagctg gctcacatcc ccagccaagc     2400

ctcgaactgt tgacaagacc agggagaatc cacccatggg cgcccaccag gttcttatgg     2460

atgcaagcag gagaagctca acaccctgcc tcttgccaag acaaggaagc ctcacctggc     2520

tttgacctgc catccgttgc tgaggccact ggcttccatc ctaagaatga ggtgcaacaa     2580

gaccccattc tcacagaacc tcaaagactt ggttccaggc tctccagaga ccatacccaa     2640

ctcatgtgca tgtgccgttt ttgcttcaag ctcagtagca ggacctgccc cgagccccct     2700

gctccttgcc cctctgtgag gagttacgga gagggctttg tctctagagc agaagagaat     2760

gatgggacgg cctgatgctg tcatgctctc cactgcacct gtggcagcct cctgagagcc     2820

accaagatct gggatgaagg ccacaccagc catgtctgct gaagggcccc agactgagat     2880

gactccggcc tccacagtta gatgtttatg gtgccagagg tctatattaa ggtagctgtc     2940

tgttgctagg cagccgtttg cacaaatctt ggacataaat ccaacttgaa gatcaa         2996


<210>  83
<211>  647
<212>  PRT
<213>  Mus musculus

<400>  83

Met Glu Gly Arg Gly Pro Tyr Gly Ile Tyr Asp Pro Gly Gly Ser Thr 
1               5                   10                  15      


Pro Leu Gly Glu Val Ser Ala Ala Phe Glu Arg Leu Val Glu Glu Asn 
            20                  25                  30          


Thr Arg Leu Lys Gly Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Ser Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Ser Glu Leu Ser Pro Pro Thr Ser Ala Pro Ser 
65                  70                  75                  80  


Leu Val Ser Phe Asp Asp Leu Ala Glu Leu Thr Gly Gln Asp Thr Lys 
                85                  90                  95      


Val Gln Val His Pro Ala Thr Ser Thr Ala Ala Thr Thr Thr Ala Thr 
            100                 105                 110         


Ala Thr Thr Gly Asn Ser Met Glu Lys Pro Glu Pro Ala Ser Lys Ser 
        115                 120                 125             


Pro Ser Asn Gly Ala Ser Ser Asp Phe Glu Val Val Pro Thr Glu Glu 
    130                 135                 140                 


Gln Asn Ser Pro Glu Thr Gly Ser His Pro Thr Asn Met Met Asp Leu 
145                 150                 155                 160 


Gly Pro Pro Pro Pro Glu Asp Ser Asn Leu Lys Leu His Leu Gln Arg 
                165                 170                 175     


Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp His Ser Gln 
            180                 185                 190         


Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn Arg Leu Ala 
        195                 200                 205             


Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu Gln Thr Leu 
    210                 215                 220                 


Cys Glu Gln Leu Arg Gln Glu Asn Glu Ala Leu Lys Ala Lys Leu Asp 
225                 230                 235                 240 


Lys Gly Leu Glu Gln Arg Asp Leu Ala Ala Glu Arg Leu Arg Glu Glu 
                245                 250                 255     


Asn Thr Glu Leu Lys Lys Leu Leu Met Asn Ser Ser Cys Lys Glu Gly 
            260                 265                 270         


Leu Cys Gly Gln Pro Ser Ser Pro Lys Pro Glu Gly Ala Gly Lys Lys 
        275                 280                 285             


Gly Val Ala Gly Gln Gln Gln Ala Ser Val Met Ala Ser Lys Val Pro 
    290                 295                 300                 


Glu Ala Gly Ala Phe Gly Ala Ala Glu Lys Lys Val Lys Leu Leu Glu 
305                 310                 315                 320 


Gln Gln Arg Met Glu Leu Leu Glu Val Asn Lys Gln Trp Asp Gln His 
                325                 330                 335     


Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr Glu Leu Arg 
            340                 345                 350         


Gln Lys Leu Val Asp Leu Gln Lys Gln Val Thr Glu Leu Glu Ala Glu 
        355                 360                 365             


Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu Leu Ala Lys 
    370                 375                 380                 


Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Lys Glu Leu Arg Gln Lys Val Arg Tyr Leu Gln Asp Gln Leu Ser 
                405                 410                 415     


Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile Gln Arg Leu 
            420                 425                 430         


Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Ala Ser Pro Ser Ser 
        435                 440                 445             


Pro Pro Ala Ala Phe Gly Ser Pro Glu Gly Val Gly Gly His Leu Arg 
    450                 455                 460                 


Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys 
465                 470                 475                 480 


Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met 
                485                 490                 495     


Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala 
            500                 505                 510         


Gln Val Thr Leu Thr Asn Ala Gln Leu Lys Thr Leu Lys Glu Glu Glu 
        515                 520                 525             


Lys Ala Lys Glu Ala Leu Lys Gln Gln Lys Arg Lys Ala Lys Ala Ser 
    530                 535                 540                 


Gly Glu Arg Tyr His Met Glu Pro His Pro Glu His Val Cys Gly Ala 
545                 550                 555                 560 


Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro His His Ala 
                565                 570                 575     


Tyr Lys Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro Val Pro Met 
            580                 585                 590         


Glu His Pro Pro Pro His Pro Asn Ser Arg Leu Phe His Leu Pro Glu 
        595                 600                 605             


Tyr Thr Trp Arg Pro Pro Cys Ala Gly Ile Arg Asn Gln Ser Ser Gln 
    610                 615                 620                 


Val Met Asp Pro Pro Pro Asp Arg Pro Ala Glu Pro Glu Ser Ala Asp 
625                 630                 635                 640 


Asn Asp Cys Asp Gly Pro Gln 
                645         


<210>  84
<211>  2666
<212>  DNA
<213>  Mus musculus

<400>  84
tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac       60

atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaaggg gagcttctgg      120

aggagtctca gatggaagcg tccagactcc ggcagaaggc agaggagctg gtcaaggaca      180

gcgagctgtc accaccgaca tctgccccct ccttggtctc ctttgatgac ctggctgagc      240

tcacaggaca ggatacaaag gtccaggtac atcctgctac cagcactgcc gccaccacca      300

ccgccaccgc caccacggga aactccatgg agaagcccga gccagcctcc aaatctccgt      360

ccaatggcgc ctcctcggac tttgaagtgg tccctactga ggagcagaat tcacccgaaa      420

ctggcagcca ccctacgaac atgatggacc tggggccccc acccccagag gacagcaacc      480

tgaagctcca cctgcagcgc ctggagacca cccttagcgt gtgtgcagag gagccagacc      540

acagccagct cttcacccac ctgggccgca tggccctcga gttcaacagg ttggcctcca      600

aagtgcataa aaatgagcag cgcacctcca tcctgcagac cttatgtgag cagctgcgcc      660

aggagaatga agccctgaag gccaagctgg acaagggcct ggaacagcgg gatctggctg      720

ctgagaggct gcgggaggaa aacacggagc tcaagaaact gttgatgaac agcagctgca      780

aagagggact ctgtgggcag cccagctccc caaagccaga gggtgctggc aagaagggcg      840

tggctggaca gcagcaggcc agtgtgatgg cgagtaaagt ccctgaagcg ggggcctttg      900

gagcagctga gaagaaggtg aagttgctag aacagcaacg catggagctg ctggaagtga      960

acaagcagtg ggaccagcat ttccggtcca tgaagcagca gtatgagcag aagatcacag     1020

agcttcgcca gaagctggtg gacctgcaga aacaggtaac tgagctggag gccgaacggg     1080

agcagaagca gcgtgacttt gaccggaaac tcctcctggc caaatcgaag atagagatgg     1140

aagagaccga caaggagcag ctgacagcag aggccaagga actgcgccag aaggtcaggt     1200

acctacagga tcagctgagc ccgctcacaa ggcaacgaga ataccaggag aaggagatcc     1260

agcggctcaa taaggccctg gaggaggccc tcagcatcca ggcctctcca tcatctccgc     1320

ctgcagcttt tgggagtcca gaaggcgttg ggggccatct gaggaagcag gaactagtga     1380

cacagaatga gttgctgaaa cagcaggtaa agatctttga agaggacttc cagagggaac     1440

ggagtgaccg tgaacgcatg aatgaagaga aggaggagct gaagaagcaa gtagagaagc     1500

tgcaggccca ggtcaccctg actaatgccc agctcaaaac tctcaaagag gaggagaagg     1560

ccaaggaagc cctcaaacag cagaagagga aagcaaaggc ttcgggagag cgctaccaca     1620

tggaacccca ccctgagcac gtctgcggcg cctatcccta tgcctaccca cccatgccag     1680

ccatggtacc tcaccatgcc tacaaggact ggtcccagat ccgataccct ccaccccctg     1740

tgcccatgga gcacccgccc ccacacccca actctcgcct cttccatctg ccggagtaca     1800

cctggcgtcc accctgtgca gggattcgga atcagagctc tcaagtgatg gacccgcccc     1860

cagacaggcc tgcagagcca gagtctgcag acaatgactg tgatgggccc cagtgaggct     1920

gcagtgggtc atttggttcc accttcatct ttcagagcca gctgacctca gattgccaaa     1980

agtttgaagg ccatgtgcat gttctgtgtg acccaagcct tggcagagga gaggctggga     2040

tgggtagctg gctcacatcc ccagccaagc ctcgaactgt tgacaagacc agggagaatc     2100

cacccatggg cgcccaccag gttcttatgg atgcaagcag gagaagctca acaccctgcc     2160

tcttgccaag acaaggaagc ctcacctggc tttgacctgc catccgttgc tgaggccact     2220

ggcttccatc ctaagaatga ggtgcaacaa gaccccattc tcacagaacc tcaaagactt     2280

ggttccaggc tctccagaga ccatacccaa ctcatgtgca tgtgccgttt ttgcttcaag     2340

ctcagtagca ggacctgccc cgagccccct gctccttgcc cctctgtgag gagttacgga     2400

gagggctttg tctctagagc agaagagaat gatgggacgg cctgatgctg tcatgctctc     2460

cactgcacct gtggcagcct cctgagagcc accaagatct gggatgaagg ccacaccagc     2520

catgtctgct gaagggcccc agactgagat gactccggcc tccacagtta gatgtttatg     2580

gtgccagagg tctatattaa ggtagctgtc tgttgctagg cagccgtttg cacaaatctt     2640

ggacataaat ccaacttgaa gatcaa                                          2666


<210>  85
<211>  2719
<212>  DNA
<213>  Mus musculus

<400>  85
tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac       60

atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaagga gacagaggaa      120

ggcagatctc tctgacttca aggcccgcct gatctccaac cgggagcttc tggaggagtc      180

tcagatggaa gcgtccagac tccggcagaa ggcagaggag ctggtcaagg acagcgagct      240

gtcaccaccg acatctgccc cctccttggt ctcctttgat gacctggctg agctcacagg      300

acaggataca aaggtccagg tacatcctgc taccagcact gccgccacca ccaccgccac      360

cgccaccacg ggaaactcca tggagaagcc cgagccagcc tccaaatctc cgtccaatgg      420

cgcctcctcg gactttgaag tggtccctac tgaggagcag aattcacccg aaactggcag      480

ccaccctacg aacatgatgg acctggggcc cccaccccca gaggacagca acctgaagct      540

ccacctgcag cgcctggaga ccacccttag cgtgtgtgca gaggagccag accacagcca      600

gctcttcacc cacctgggcc gcatggccct cgagttcaac aggttggcct ccaaagtgca      660

taaaaatgag cagcgcacct ccatcctgca gaccttatgt gagcagctgc gccaggagaa      720

tgaagccctg aaggccaagc tggacaaggg cctggaacag cgggatctgg ctgctgagag      780

gctgcgggag gaaaacacgg agctcaagaa actgttgatg aacagcagct gcaaagaggg      840

actctgtggg cagcccagct ccccaaagcc agagggtgct ggcaagaagg gcgtggctgg      900

acagcagcag gccagtgtga tggcgagtaa agtccctgaa gcgggggcct ttggagcagc      960

tgagaagaag gtgaagttgc tagaacagca acgcatggag ctgctggaag tgaacaagca     1020

gtgggaccag catttccggt ccatgaagca gcagtatgag cagaagatca cagagcttcg     1080

ccagaagctg gtggacctgc agaaacaggt aactgagctg gaggccgaac gggagcagaa     1140

gcagcgtgac tttgaccgga aactcctcct ggccaaatcg aagatagaga tggaagagac     1200

cgacaaggag cagctgacag cagaggccaa ggaactgcgc cagaaggtca ggtacctaca     1260

ggatcagctg agcccgctca caaggcaacg agaataccag gagaaggaga tccagcggct     1320

caataaggcc ctggaggagg ccctcagcat ccaggcctct ccatcatctc cgcctgcagc     1380

ttttgggagt ccagaaggcg ttgggggcca tctgaggaag caggaactag tgacacagaa     1440

tgagttgctg aaacagcagg taaagatctt tgaagaggac ttccagaggg aacggagtga     1500

ccgtgaacgc atgaatgaag agaaggagga gctgaagaag caagtagaga agctgcaggc     1560

ccaggtcacc ctgactaatg cccagctcaa aactctcaaa gaggaggaga aggccaagga     1620

agccctcaaa cagcagaaga ggaaagcaaa ggcttcggga gagcgctacc acatggaacc     1680

ccaccctgag cacgtctgcg gcgcctatcc ctatgcctac ccacccatgc cagccatggt     1740

acctcaccat gcctacaagg actggtccca gatccgatac cctccacccc ctgtgcccat     1800

ggagcacccg cccccacacc ccaactctcg cctcttccat ctgccggagt acacctggcg     1860

tccaccctgt gcagggattc ggaatcagag ctctcaagtg atggacccgc ccccagacag     1920

gcctgcagag ccagagtctg cagacaatga ctgtgatggg ccccagtgag gctgcagtgg     1980

gtcatttggt tccaccttca tctttcagag ccagctgacc tcagattgcc aaaagtttga     2040

aggccatgtg catgttctgt gtgacccaag ccttggcaga ggagaggctg ggatgggtag     2100

ctggctcaca tccccagcca agcctcgaac tgttgacaag accagggaga atccacccat     2160

gggcgcccac caggttctta tggatgcaag caggagaagc tcaacaccct gcctcttgcc     2220

aagacaagga agcctcacct ggctttgacc tgccatccgt tgctgaggcc actggcttcc     2280

atcctaagaa tgaggtgcaa caagacccca ttctcacaga acctcaaaga cttggttcca     2340

ggctctccag agaccatacc caactcatgt gcatgtgccg tttttgcttc aagctcagta     2400

gcaggacctg ccccgagccc cctgctcctt gcccctctgt gaggagttac ggagagggct     2460

ttgtctctag agcagaagag aatgatggga cggcctgatg ctgtcatgct ctccactgca     2520

cctgtggcag cctcctgaga gccaccaaga tctgggatga aggccacacc agccatgtct     2580

gctgaagggc cccagactga gatgactccg gcctccacag ttagatgttt atggtgccag     2640

aggtctatat taaggtagct gtctgttgct aggcagccgt ttgcacaaat cttggacata     2700

aatccaactt gaagatcaa                                                  2719


<210>  86
<211>  594
<212>  PRT
<213>  Mus musculus

<400>  86

Met Glu Ala Ser Arg Leu Arg Gln Lys Ala Glu Glu Leu Val Lys Asp 
1               5                   10                  15      


Ser Glu Leu Ser Pro Pro Thr Ser Ala Pro Ser Leu Val Ser Phe Asp 
            20                  25                  30          


Asp Leu Ala Glu Leu Thr Gly Gln Asp Thr Lys Val Gln Val His Pro 
        35                  40                  45              


Ala Thr Ser Thr Ala Ala Thr Thr Thr Ala Thr Ala Thr Thr Gly Asn 
    50                  55                  60                  


Ser Met Glu Lys Pro Glu Pro Ala Ser Lys Ser Pro Ser Asn Gly Ala 
65                  70                  75                  80  


Ser Ser Asp Phe Glu Val Val Pro Thr Glu Glu Gln Asn Ser Pro Glu 
                85                  90                  95      


Thr Gly Ser His Pro Thr Asn Met Met Asp Leu Gly Pro Pro Pro Pro 
            100                 105                 110         


Glu Asp Ser Asn Leu Lys Leu His Leu Gln Arg Leu Glu Thr Thr Leu 
        115                 120                 125             


Ser Val Cys Ala Glu Glu Pro Asp His Ser Gln Leu Phe Thr His Leu 
    130                 135                 140                 


Gly Arg Met Ala Leu Glu Phe Asn Arg Leu Ala Ser Lys Val His Lys 
145                 150                 155                 160 


Asn Glu Gln Arg Thr Ser Ile Leu Gln Thr Leu Cys Glu Gln Leu Arg 
                165                 170                 175     


Gln Glu Asn Glu Ala Leu Lys Ala Lys Leu Asp Lys Gly Leu Glu Gln 
            180                 185                 190         


Arg Asp Leu Ala Ala Glu Arg Leu Arg Glu Glu Asn Thr Glu Leu Lys 
        195                 200                 205             


Lys Leu Leu Met Asn Ser Ser Cys Lys Glu Gly Leu Cys Gly Gln Pro 
    210                 215                 220                 


Ser Ser Pro Lys Pro Glu Gly Ala Gly Lys Lys Gly Val Ala Gly Gln 
225                 230                 235                 240 


Gln Gln Ala Ser Val Met Ala Ser Lys Val Pro Glu Ala Gly Ala Phe 
                245                 250                 255     


Gly Ala Ala Glu Lys Lys Val Lys Leu Leu Glu Gln Gln Arg Met Glu 
            260                 265                 270         


Leu Leu Glu Val Asn Lys Gln Trp Asp Gln His Phe Arg Ser Met Lys 
        275                 280                 285             


Gln Gln Tyr Glu Gln Lys Ile Thr Glu Leu Arg Gln Lys Leu Val Asp 
    290                 295                 300                 


Leu Gln Lys Gln Val Thr Glu Leu Glu Ala Glu Arg Glu Gln Lys Gln 
305                 310                 315                 320 


Arg Asp Phe Asp Arg Lys Leu Leu Leu Ala Lys Ser Lys Ile Glu Met 
                325                 330                 335     


Glu Glu Thr Asp Lys Glu Gln Leu Thr Ala Glu Ala Lys Glu Leu Arg 
            340                 345                 350         


Gln Lys Val Arg Tyr Leu Gln Asp Gln Leu Ser Pro Leu Thr Arg Gln 
        355                 360                 365             


Arg Glu Tyr Gln Glu Lys Glu Ile Gln Arg Leu Asn Lys Ala Leu Glu 
    370                 375                 380                 


Glu Ala Leu Ser Ile Gln Ala Ser Pro Ser Ser Pro Pro Ala Ala Phe 
385                 390                 395                 400 


Gly Ser Pro Glu Gly Val Gly Gly His Leu Arg Lys Gln Glu Leu Val 
                405                 410                 415     


Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys Ile Phe Glu Glu Asp 
            420                 425                 430         


Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met Asn Glu Glu Lys Glu 
        435                 440                 445             


Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala Gln Val Thr Leu Thr 
    450                 455                 460                 


Asn Ala Gln Leu Lys Thr Leu Lys Glu Glu Glu Lys Ala Lys Glu Ala 
465                 470                 475                 480 


Leu Lys Gln Gln Lys Arg Lys Ala Lys Ala Ser Gly Glu Arg Tyr His 
                485                 490                 495     


Met Glu Pro His Pro Glu His Val Cys Gly Ala Tyr Pro Tyr Ala Tyr 
            500                 505                 510         


Pro Pro Met Pro Ala Met Val Pro His His Ala Tyr Lys Asp Trp Ser 
        515                 520                 525             


Gln Ile Arg Tyr Pro Pro Pro Pro Val Pro Met Glu His Pro Pro Pro 
    530                 535                 540                 


His Pro Asn Ser Arg Leu Phe His Leu Pro Glu Tyr Thr Trp Arg Pro 
545                 550                 555                 560 


Pro Cys Ala Gly Ile Arg Asn Gln Ser Ser Gln Val Met Asp Pro Pro 
                565                 570                 575     


Pro Asp Arg Pro Ala Glu Pro Glu Ser Ala Asp Asn Asp Cys Asp Gly 
            580                 585                 590         


Pro Gln 
        


<210>  87
<211>  2817
<212>  DNA
<213>  Mus musculus

<400>  87
tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac       60

atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaagga gacagaggaa      120

ggcagatctc tctgacttca aggcccgcct gatctccaac cctaggcggc cgtcacggca      180

ggggttgagc caccctcatg gaagggagag gaccctacgg gatctacgac ccagggggca      240

gcacgcctct gggagaggtg tccgcagctt ttgaacgtct agtggaggag aatactcggc      300

tgaagggaaa aatgcaaggg ataaagatgt taggggagct tctggaggag tctcagatgg      360

aagcgtccag actccggcag aaggcagagg agctggtcaa ggacagcgag ctgtcaccac      420

cgacatctgc cccctccttg gtctcctttg atgacctggc tgagctcaca ggacaggata      480

caaaggtcca ggtacatcct gctaccagca ctgccgccac caccaccgcc accgccacca      540

cgggaaactc catggagaag cccgagccag cctccaaatc tccgtccaat ggcgcctcct      600

cggactttga agtggtccct actgaggagc agaattcacc cgaaactggc agccacccta      660

cgaacatgat ggacctgggg cccccacccc cagaggacag caacctgaag ctccacctgc      720

agcgcctgga gaccaccctt agcgtgtgtg cagaggagcc agaccacagc cagctcttca      780

cccacctggg ccgcatggcc ctcgagttca acaggttggc ctccaaagtg cataaaaatg      840

agcagcgcac ctccatcctg cagaccttat gtgagcagct gcgccaggag aatgaagccc      900

tgaaggccaa gctggacaag ggcctggaac agcgggatct ggctgctgag aggctgcggg      960

aggaaaacac ggagctcaag aaactgttga tgaacagcag ctgcaaagag ggactctgtg     1020

ggcagcccag ctccccaaag ccagagggtg ctggcaagaa gggcgtggct ggacagcagc     1080

aggccagtgt gatggcgagt aaagtccctg aagcgggggc ctttggagca gctgagaaga     1140

aggtgaagtt gctagaacag caacgcatgg agctgctgga agtgaacaag cagtgggacc     1200

agcatttccg gtccatgaag cagcagtatg agcagaagat cacagagctt cgccagaagc     1260

tggtggacct gcagaaacag gtaactgagc tggaggccga acgggagcag aagcagcgtg     1320

actttgaccg gaaactcctc ctggccaaat cgaagataga gatggaagag accgacaagg     1380

agcagctgac agcagaggcc aaggaactgc gccagaaggt caggtaccta caggatcagc     1440

tgagcccgct cacaaggcaa cgagaatacc aggagaagga gatccagcgg ctcaataagg     1500

ccctggagga ggccctcagc atccaggcct ctccatcatc tccgcctgca gcttttggga     1560

gtccagaagg cgttgggggc catctgagga agcaggaact agtgacacag aatgagttgc     1620

tgaaacagca ggtaaagatc tttgaagagg acttccagag ggaacggagt gaccgtgaac     1680

gcatgaatga agagaaggag gagctgaaga agcaagtaga gaagctgcag gcccaggtca     1740

ccctgactaa tgcccagctc aaaactctca aagaggagga gaaggccaag gaagccctca     1800

aacagcagaa gaggaaagca aaggcttcgg gagagcgcta ccacatggaa ccccaccctg     1860

agcacgtctg cggcgcctat ccctatgcct acccacccat gccagccatg gtacctcacc     1920

atgcctacaa ggactggtcc cagatccgat accctccacc ccctgtgccc atggagcacc     1980

cgcccccaca ccccaactct cgcctcttcc atctgccgga gtacacctgg cgtccaccct     2040

gtgcagggat tcggaatcag agctctcaag tgatggaccc gcccccagac aggcctgcag     2100

agccagagcc agctgacctc agattgccaa aagtttgaag gccatgtgca tgttctgtgt     2160

gacccaagcc ttggcagagg agaggctggg atgggtagct ggctcacatc cccagccaag     2220

cctcgaactg ttgacaagac cagggagaat ccacccatgg gcgcccacca ggttcttatg     2280

gatgcaagca ggagaagctc aacaccctgc ctcttgccaa gacaaggaag cctcacctgg     2340

ctttgacctg ccatccgttg ctgaggccac tggcttccat cctaagaatg aggtgcaaca     2400

agaccccatt ctcacagaac ctcaaagact tggttccagg ctctccagag accataccca     2460

actcatgtgc atgtgccgtt tttgcttcaa gctcagtagc aggacctgcc ccgagccccc     2520

tgctccttgc ccctctgtga ggagttacgg agagggcttt gtctctagag cagaagagaa     2580

tgatgggacg gcctgatgct gtcatgctct ccactgcacc tgtggcagcc tcctgagagc     2640

caccaagatc tgggatgaag gccacaccag ccatgtctgc tgaagggccc cagactgaga     2700

tgactccggc ctccacagtt agatgtttat ggtgccagag gtctatatta aggtagctgt     2760

ctgttgctag gcagccgttt gcacaaatct tggacataaa tccaacttga agatcaa        2817


<210>  88
<211>  646
<212>  PRT
<213>  Mus musculus

<400>  88

Met Glu Gly Arg Gly Pro Tyr Gly Ile Tyr Asp Pro Gly Gly Ser Thr 
1               5                   10                  15      


Pro Leu Gly Glu Val Ser Ala Ala Phe Glu Arg Leu Val Glu Glu Asn 
            20                  25                  30          


Thr Arg Leu Lys Gly Lys Met Gln Gly Ile Lys Met Leu Gly Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Gln Met Glu Ala Ser Arg Leu Arg Gln Lys Ala Glu 
    50                  55                  60                  


Glu Leu Val Lys Asp Ser Glu Leu Ser Pro Pro Thr Ser Ala Pro Ser 
65                  70                  75                  80  


Leu Val Ser Phe Asp Asp Leu Ala Glu Leu Thr Gly Gln Asp Thr Lys 
                85                  90                  95      


Val Gln Val His Pro Ala Thr Ser Thr Ala Ala Thr Thr Thr Ala Thr 
            100                 105                 110         


Ala Thr Thr Gly Asn Ser Met Glu Lys Pro Glu Pro Ala Ser Lys Ser 
        115                 120                 125             


Pro Ser Asn Gly Ala Ser Ser Asp Phe Glu Val Val Pro Thr Glu Glu 
    130                 135                 140                 


Gln Asn Ser Pro Glu Thr Gly Ser His Pro Thr Asn Met Met Asp Leu 
145                 150                 155                 160 


Gly Pro Pro Pro Pro Glu Asp Ser Asn Leu Lys Leu His Leu Gln Arg 
                165                 170                 175     


Leu Glu Thr Thr Leu Ser Val Cys Ala Glu Glu Pro Asp His Ser Gln 
            180                 185                 190         


Leu Phe Thr His Leu Gly Arg Met Ala Leu Glu Phe Asn Arg Leu Ala 
        195                 200                 205             


Ser Lys Val His Lys Asn Glu Gln Arg Thr Ser Ile Leu Gln Thr Leu 
    210                 215                 220                 


Cys Glu Gln Leu Arg Gln Glu Asn Glu Ala Leu Lys Ala Lys Leu Asp 
225                 230                 235                 240 


Lys Gly Leu Glu Gln Arg Asp Leu Ala Ala Glu Arg Leu Arg Glu Glu 
                245                 250                 255     


Asn Thr Glu Leu Lys Lys Leu Leu Met Asn Ser Ser Cys Lys Glu Gly 
            260                 265                 270         


Leu Cys Gly Gln Pro Ser Ser Pro Lys Pro Glu Gly Ala Gly Lys Lys 
        275                 280                 285             


Gly Val Ala Gly Gln Gln Gln Ala Ser Val Met Ala Ser Lys Val Pro 
    290                 295                 300                 


Glu Ala Gly Ala Phe Gly Ala Ala Glu Lys Lys Val Lys Leu Leu Glu 
305                 310                 315                 320 


Gln Gln Arg Met Glu Leu Leu Glu Val Asn Lys Gln Trp Asp Gln His 
                325                 330                 335     


Phe Arg Ser Met Lys Gln Gln Tyr Glu Gln Lys Ile Thr Glu Leu Arg 
            340                 345                 350         


Gln Lys Leu Val Asp Leu Gln Lys Gln Val Thr Glu Leu Glu Ala Glu 
        355                 360                 365             


Arg Glu Gln Lys Gln Arg Asp Phe Asp Arg Lys Leu Leu Leu Ala Lys 
    370                 375                 380                 


Ser Lys Ile Glu Met Glu Glu Thr Asp Lys Glu Gln Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Lys Glu Leu Arg Gln Lys Val Arg Tyr Leu Gln Asp Gln Leu Ser 
                405                 410                 415     


Pro Leu Thr Arg Gln Arg Glu Tyr Gln Glu Lys Glu Ile Gln Arg Leu 
            420                 425                 430         


Asn Lys Ala Leu Glu Glu Ala Leu Ser Ile Gln Ala Ser Pro Ser Ser 
        435                 440                 445             


Pro Pro Ala Ala Phe Gly Ser Pro Glu Gly Val Gly Gly His Leu Arg 
    450                 455                 460                 


Lys Gln Glu Leu Val Thr Gln Asn Glu Leu Leu Lys Gln Gln Val Lys 
465                 470                 475                 480 


Ile Phe Glu Glu Asp Phe Gln Arg Glu Arg Ser Asp Arg Glu Arg Met 
                485                 490                 495     


Asn Glu Glu Lys Glu Glu Leu Lys Lys Gln Val Glu Lys Leu Gln Ala 
            500                 505                 510         


Gln Val Thr Leu Thr Asn Ala Gln Leu Lys Thr Leu Lys Glu Glu Glu 
        515                 520                 525             


Lys Ala Lys Glu Ala Leu Lys Gln Gln Lys Arg Lys Ala Lys Ala Ser 
    530                 535                 540                 


Gly Glu Arg Tyr His Met Glu Pro His Pro Glu His Val Cys Gly Ala 
545                 550                 555                 560 


Tyr Pro Tyr Ala Tyr Pro Pro Met Pro Ala Met Val Pro His His Ala 
                565                 570                 575     


Tyr Lys Asp Trp Ser Gln Ile Arg Tyr Pro Pro Pro Pro Val Pro Met 
            580                 585                 590         


Glu His Pro Pro Pro His Pro Asn Ser Arg Leu Phe His Leu Pro Glu 
        595                 600                 605             


Tyr Thr Trp Arg Pro Pro Cys Ala Gly Ile Arg Asn Gln Ser Ser Gln 
    610                 615                 620                 


Val Met Asp Pro Pro Pro Asp Arg Pro Ala Glu Pro Glu Pro Ala Asp 
625                 630                 635                 640 


Leu Arg Leu Pro Lys Val 
                645     


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  89
gcctgctgtc acttgctacg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  90
aatcaaccag agaatttccg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  91
ggtccagctc ccgttctaca                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  92
gtatggcagc aacgtcacga                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  93
tatagagctg aaaaaccgca                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  94
ccacattacg gacgatgcaa                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  95
tcttacgagg aggagaaagg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  96
gcaagtgtag tttcccacca                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  97
gcgaggtatt cggctccgcg                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  98
gctttcacgg aggttcgacg                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  99
atgttgcagt tcggctcgat                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  100
acgtgtaagg cgaacgcctt                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  101
attgttcgac cgtctacggg                                                   20


<210>  102
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  102
caccgtacac gtccgacttc tccg                                              24