                         SEQUENCE LISTING

<110>  UNIVERSITY OF MASSACHUSETTS
 
<120>  Methods and Compositions for Treating Inflammation

<130>  UMASS-W-19107

<140>  PCT/US18/42116
<141>  2018-07-14

<150>  US 62/532,539
<151>  2017-07-14

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2335
<212>  DNA
<213>  Homo sapiens

<400>  1
cggctcccct cgcctaagct gctggggggc gccatgggcc gctaccgcat ccgcgtggcc       60

accggggcct ggctcttctc cgggtcgtac aaccgcgtgc agctttggct ggtcgggacg      120

cgcggggagg cggagctgga gctgcagctg cggccggcgc ggggcgagga ggaggagttt      180

gatcatgacg ttgcagagga cttggggctc ctgcagttcg tgaggctgcg caagcaccac      240

tggctggtgg acgacgcgtg gttctgcgac cgcatcacgg tgcagggccc tggagcctgc      300

gcggaggtgg ccttcccgtg ctaccgctgg gtgcagggcg aggacatcct gagcctgccc      360

gagggcaccg cccgcctgcc aggagacaat gctttggaca tgttccagaa gcatcgagag      420

aaggaactga aagacagaca gcagatctac tgctgggcca cctggaagga agggttaccc      480

ctgaccatcg ctgcagaccg taaggatgat ctacctccaa atatgagatt ccatgaggag      540

aagaggctgg actttgaatg gacactgaag gcaggggctc tggagatggc cctcaaacgt      600

gtttacaccc tcctgagctc ctggaactgc ctagaagact ttgatcagat cttctggggc      660

cagaagagtg ccctggctga gaaggttcgc cagtgctggc aggatgatga gttgttcagc      720

taccagttcc tcaatggtgc caaccccatg ctgttgagac gctcgacctc tctgccctcc      780

aggctagtgc tgccctcagg gatggaagag cttcgggctc aactggagaa agaacttcag      840

aatggttccc tgtttgaagc tgacttcatc cttctggatg gaattccagc caacgtgatc      900

cgaggagaga agcaatacct ggctgccccc ctcgttatgc tgaagatgga gcccaatggg      960

aagctgcagc ccatggtcat ccagattcag cctcccaacc ccagctctcc aaccccaaca     1020

ctgttcctgc cctcagaccc cccacttgcc tggctcctgg caaagtcctg ggtccgaaat     1080

tcagatttcc aactgcacga gatccagtat cacttgctga acacgcacct ggtggctgag     1140

gtcatcgctg tcgccaccat gcggtgcctc ccaggactgc accccatctt caagttcctg     1200

atcccccata tccgctacac catggaaatc aacacccggg cccggaccca actcatctca     1260

gatggaggaa tttttgataa ggcagtgagc acaggtggag ggggccatgt acagttgctc     1320

cgtcgggcgg cagctcagct gacctactgc tccctctgtc ctcctgacga cctggctgac     1380

cggggcctgc tgggactccc aggtgctctc tatgcccatg atgctttacg gctctgggag     1440

atcattgcca ggtatgtgga ggggatcgtc cacctcttct accaaaggga tgacatagtg     1500

aagggggacc ctgagctgca ggcctggtgt cgggagatca cggaggtggg gctgtgccag     1560

gcccaggacc gaggtttccc tgtctccttc cagtcccaga gtcaactctg ccatttcctc     1620

accatgtgcg tcttcacgtg cactgcccag catgccgcca tcaaccaggg ccagctggac     1680

tggtatgcct gggtccctaa tgctccatgc acaatgcgga tgcccccacc caccaccaag     1740

gaagatgtga cgatggccac agtgatgggg tcactacctg atgtccggca ggcctgtctt     1800

caaatggcca tctcatggca tctgagtcgc cgccagccag acatggtgcc tctggggcac     1860

cacaaagaaa aatatttctc aggccccaag cccaaagctg tgctaaacca attccgaaca     1920

gatttggaaa agctggaaaa ggagattaca gcccggaatg agcaacttga ctggccctat     1980

gaatatctga agcccagctg catagagaac agtgtcacca tctgagccct agagtgactc     2040

tacctgcaag atttcacatc agctttagga ctgacatttc tatcttgaat ttcatgcttt     2100

cctaaagtct ctgctgctaa ggctctattt cctcccccag ttaaaccccc tacattagta     2160

tcccactagc ccaggggagc agtaaacttt ctctgcaaag actagatcct tttttacgct     2220

ttgcagaccg catagtcact gtctcaacta ctcagctctc ctgctgcagc atgaaggcag     2280

ccacagacaa catggaaatg agtgtgacta tgttccaata aaactttatg gacac          2335


<210>  2
<211>  5446
<212>  DNA
<213>  Homo sapiens

<400>  2
tactttggga actggtgagt ctccctgtcc ctagggcttt ttagtcacat gtccatccac       60

tgtttcaatg taacatgcat ctaggcaagg ttaacgatta aatggttggg atgaaaggtc      120

atcctttacg gagaacatca gaatggtaga taattcctgt tccactttct ttgatgaaac      180

aagtaaagaa gaaacaacac aatcatatta atagaagagt cttcgttcca gacgcagtcc      240

aggaatcatg ctggagaagt tctgcaactc tactttttgg aattcctcat tcctggacag      300

tccggaggca gacctgccac tttgttttga gcaaactgtt ctggtgtgga ttcccttggg      360

cttcctatgg ctcctggccc cctggcagct tctccacgtg tataaatcca ggaccaagag      420

atcctctacc accaaactct atcttgctaa gcaggtattc gttggttttc ttcttattct      480

agcagccata gagctggccc ttgtactcac agaagactct ggacaagcca cagtccctgc      540

tgttcgatat accaatccaa gcctctacct aggcacatgg ctcctggttt tgctgatcca      600

atacagcaga caatggtgtg tacagaaaaa ctcctggttc ctgtccctat tctggattct      660

ctcgatactc tgtggcactt tccaatttca gactctgatc cggacactct tacagggtga      720

caattctaat ctagcctact cctgcctgtt cttcatctcc tacggattcc agatcctgat      780

cctgatcttt tcagcatttt cagaaaataa tgagtcatca aataatccat catccatagc      840

ttcattcctg agtagcatta cctacagctg gtatgacagc atcattctga aaggctacaa      900

gcgtcctctg acactcgagg atgtctggga agttgatgaa gagatgaaaa ccaagacatt      960

agtgagcaag tttgaaacgc acatgaagag agagctgcag aaagccaggc gggcactcca     1020

gagacggcag gagaagagct cccagcagaa ctctggagcc aggctgcctg gcttgaacaa     1080

gaatcagagt caaagccaag atgcccttgt cctggaagat gttgaaaaga aaaaaaagaa     1140

gtctgggacc aaaaaagatg ttccaaaatc ctggttgatg aaggctctgt tcaaaacttt     1200

ctacatggtg ctcctgaaat cattcctact gaagctagtg aatgacatct tcacgtttgt     1260

gagtcctcag ctgctgaaat tgctgatctc ctttgcaagt gaccgtgaca catatttgtg     1320

gattggatat ctctgtgcaa tcctcttatt cactgcggct ctcattcagt ctttctgcct     1380

tcagtgttat ttccaactgt gcttcaagct gggtgtaaaa gtacggacag ctatcatggc     1440

ttctgtatat aagaaggcat tgaccctatc caacttggcc aggaaggagt acaccgttgg     1500

agaaacagtg aacctgatgt ctgtggatgc ccagaagctc atggatgtga ccaacttcat     1560

gcacatgctg tggtcaagtg ttctacagat tgtcttatct atcttcttcc tatggagaga     1620

gttgggaccc tcagtcttag caggtgttgg ggtgatggtg cttgtaatcc caattaatgc     1680

gatactgtcc accaagagta agaccattca ggtcaaaaat atgaagaata aagacaaacg     1740

tttaaagatc atgaatgaga ttcttagtgg aatcaagatc ctgaaatatt ttgcctggga     1800

accttcattc agagaccaag tacaaaacct ccggaagaaa gagctcaaga acctgctggc     1860

ctttagtcaa ctacagtgtg tagtaatatt cgtcttccag ttaactccag tcctggtatc     1920

tgtggtcaca ttttctgttt atgtcctggt ggatagcaac aatattttgg atgcacaaaa     1980

ggccttcacc tccattaccc tcttcaatat cctgcgcttt cccctgagca tgcttcccat     2040

gatgatctcc tccatgctcc aggccagtgt ttccacagag cggctagaga agtacttggg     2100

aggggatgac ttggacacat ctgccattcg acatgactgc aattttgaca aagccatgca     2160

gttttctgag gcctccttta cctgggaaca tgattcggaa gccacagtcc gagatgtgaa     2220

cctggacatt atggcaggcc aacttgtggc tgtgataggc cctgtcggct ctgggaaatc     2280

ctccttgata tcagccatgc tgggagaaat ggaaaatgtc cacgggcaca tcaccatcaa     2340

gggcaccact gcctatgtcc cacagcagtc ctggattcag aatggcacca taaaggacaa     2400

catccttttt ggaacagagt ttaatgaaaa gaggtaccag caagtactgg aggcctgtgc     2460

tctcctccca gacttggaaa tgctgcctgg aggagatttg gctgagattg gagagaaggg     2520

tataaatctt agtgggggtc agaagcagcg gatcagcctg gccagagcta cctaccaaaa     2580

tttagacatc tatcttctag atgaccccct gtctgcagtg gatgctcatg taggaaaaca     2640

tatttttaat aaggtcttgg gccccaatgg cctgttgaaa ggcaagactc gactcttggt     2700

tacacatagc atgcactttc ttcctcaagt ggatgagatt gtagttctgg ggaatggaac     2760

aattgtagag aaaggatcct acagtgctct cctggccaaa aaaggagagt ttgctaagaa     2820

tctgaagaca tttctaagac atacaggccc tgaagaggaa gccacagtcc atgatggcag     2880

tgaagaagaa gacgatgact atgggctgat atccagtgtg gaagagatcc ccgaagatgc     2940

agcctccata accatgagaa gagagaacag ctttcgtcga acacttagcc gcagttctag     3000

gtccaatggc aggcatctga agtccctgag aaactccttg aaaactcgga atgtgaatag     3060

cctgaaggaa gacgaagaac tagtgaaagg acaaaaacta attaagaagg aattcataga     3120

aactggaaag gtgaagttct ccatctacct ggagtaccta caagcaatag gattgttttc     3180

gatattcttc atcatccttg cgtttgtgat gaattctgtg gcttttattg gatccaacct     3240

ctggctcagt gcttggacca gtgactctaa aatcttcaat agcaccgact atccagcatc     3300

tcagagggac atgagagttg gagtctacgg agctctggga ttagcccaag gtatatttgt     3360

gttcatagca catttctgga gtgcctttgg tttcgtccat gcatcaaata tcttgcacaa     3420

gcaactgctg aacaatatcc ttcgagcacc tatgagattt tttgacacaa cacccacagg     3480

ccggattgtg aacaggtttg ccggcgatat ttccacagtg gatgacaccc tgcctcagtc     3540

cttgcgcagc tggattacat gcttcctggg gataatcagc acccttgtca tgatctgcat     3600

ggccactcct gtcttcacca tcatcgtcat tcctcttggc attatttatg tatctgttca     3660

gatgttttat gtgtctacct cccgccagct gaggcgtctg gactctgtca ccaggtcccc     3720

aatctactct cacttcagcg agaccgtatc aggtttgcca gttatccgtg cctttgagca     3780

ccagcagcga tttctgaaac acaatgaggt gaggattgac accaaccaga aatgtgtctt     3840

ttcctggatc acctccaaca ggtggcttgc aattcgcctg gagctggttg ggaacctgac     3900

tgtcttcttt tcagccttga tgatggttat ttatagagat accctaagtg gggacactgt     3960

tggctttgtt ctgtccaatg cactcaatat cacacaaacc ctgaactggc tggtgaggat     4020

gacatcagaa atagagacca acattgtggc tgttgagcga ataactgagt acacaaaagt     4080

ggaaaatgag gcaccctggg tgactgataa gaggcctccg ccagattggc ccagcaaagg     4140

caagatccag tttaacaact accaagtgcg gtaccgacct gagctggatc tggtcctcag     4200

agggatcact tgtgacatcg gtagcatgga gaagattggt gtggtgggca ggacaggagc     4260

tggaaagtca tccctcacaa actgcctctt cagaatctta gaggctgccg gtggtcagat     4320

tatcattgat ggagtagata ttgcttccat tgggctccac gacctccgag agaagctgac     4380

catcatcccc caggacccca tcctgttctc tggaagcctg aggatgaatc tcgacccttt     4440

caacaactac tcagatgagg agatttggaa ggccttggag ctggctcacc tcaagtcttt     4500

tgtggccagc ctgcaacttg ggttatccca cgaagtgaca gaggctggtg gcaacctgag     4560

cataggccag aggcagctgc tgtgcctggg cagggctctg cttcggaaat ccaagatcct     4620

ggtcctggat gaggccactg ctgcggtgga tctagagaca gacaacctca ttcagacgac     4680

catccaaaac gagttcgccc actgcacagt gatcaccatc gcccacaggc tgcacaccat     4740

catggacagt gacaaggtaa tggtcctaga caacgggaag attatagagt gcggcagccc     4800

tgaagaactg ctacaaatcc ctggaccctt ttactttatg gctaaggaag ctggcattga     4860

gaatgtgaac agcacaaaat tctagcagaa ggccccatgg gttagaaaag gactataaga     4920

ataatttctt atttaatttt attttttata aaatacagaa tacatacaaa agtgtgtata     4980

aaatgtacgt tttaaaaaag gataagtgaa cacccatgaa cctactaccc aggttaagaa     5040

aataaatgtc accaggtact tgagaaaccc ctcgattgtc tacctcgatc gtacttcctt     5100

gctacccacc cctcccaggg acaaccactg tcctgaattt cacgataatt attcctttgc     5160

ctttcatttc tgttttatca cctttgtatg tatctttaaa caacatatac ccttttttac     5220

ttatgtaaat ggactgactc atactgcata catcttctat gacttgattc ttttgttcaa     5280

tattatatct gagattcatc catggtgatg caaataggtg cattattttt tttcactgct     5340

ctgtagtctg gcattgtatg aatacagcac aatgtatcag ttttaatatt ggggatcatt     5400

agcattattc tcaggttttt aaaaattata agcagtacta ctatgg                    5446


<210>  3
<211>  4718
<212>  DNA
<213>  Homo sapiens

<400>  3
aaacacttgt attaccattt taaaggctat cattactctt tacctgtgaa gagtagaaca       60

tgaagaaatc tactttattc agatattctc cagattccta aagattagag atcatttctc      120

attctcctag gagtactcac ttcaggaagc aaccagataa aagagaggtg caacggaagc      180

cagaacattc ctcctggaaa ttcaacctgt ttcgcagttt ctcgaggaat cagcattcag      240

tcaatccggg ccgggagcag tcatctgtgg tgaggctgat tggctgggca ggaacagcgc      300

cggggcgtgg gctgagcaca gccgcttcgc tctctttgcc acaggaagcc tgagctcatt      360

cgagtagcgg ctcttccaag ctcaaagaag cagaggccgc tgttcgtttc ctttaggtct      420

ttccactaaa gtcggagtat cttcttccaa aatttcacgt cttggtggcc gttccaagga      480

gcgcgaggtc ggaatggatc ttgaagggga ccgcaatgga ggagcaaaga agaagaactt      540

ttttaaactg aacaataaaa gtgaaaaaga taagaaggaa aagaaaccaa ctgtcagtgt      600

attttcaatg tttcgctatt caaattggct tgacaagttg tatatggtgg tgggaacttt      660

ggctgccatc atccatgggg ctggacttcc tctcatgatg ctggtgtttg gagaaatgac      720

agatatcttt gcaaatgcag gaaatttaga agatctgatg tcaaacatca ctaatagaag      780

tgatatcaat gatacagggt tcttcatgaa tctggaggaa gacatgacca ggtatgccta      840

ttattacagt ggaattggtg ctggggtgct ggttgctgct tacattcagg tttcattttg      900

gtgcctggca gctggaagac aaatacacaa aattagaaaa cagttttttc atgctataat      960

gcgacaggag ataggctggt ttgatgtgca cgatgttggg gagcttaaca cccgacttac     1020

agatgatgtc tccaagatta atgaaggaat tggtgacaaa attggaatgt tctttcagtc     1080

aatggcaaca tttttcactg ggtttatagt aggatttaca cgtggttgga agctaaccct     1140

tgtgattttg gccatcagtc ctgttcttgg actgtcagct gctgtctggg caaagatact     1200

atcttcattt actgataaag aactcttagc gtatgcaaaa gctggagcag tagctgaaga     1260

ggtcttggca gcaattagaa ctgtgattgc atttggagga caaaagaaag aacttgaaag     1320

gtacaacaaa aatttagaag aagctaaaag aattgggata aagaaagcta ttacagccaa     1380

tatttctata ggtgctgctt tcctgctgat ctatgcatct tatgctctgg ccttctggta     1440

tgggaccacc ttggtcctct caggggaata ttctattgga caagtactca ctgtattctt     1500

ttctgtatta attggggctt ttagtgttgg acaggcatct ccaagcattg aagcatttgc     1560

aaatgcaaga ggagcagctt atgaaatctt caagataatt gataataagc caagtattga     1620

cagctattcg aagagtgggc acaaaccaga taatattaag ggaaatttgg aattcagaaa     1680

tgttcacttc agttacccat ctcgaaaaga agttaagatc ttgaagggtc tgaacctgaa     1740

ggtgcagagt gggcagacgg tggccctggt tggaaacagt ggctgtggga agagcacaac     1800

agtccagctg atgcagaggc tctatgaccc cacagagggg atggtcagtg ttgatggaca     1860

ggatattagg accataaatg taaggtttct acgggaaatc attggtgtgg tgagtcagga     1920

acctgtattg tttgccacca cgatagctga aaacattcgc tatggccgtg aaaatgtcac     1980

catggatgag attgagaaag ctgtcaagga agccaatgcc tatgacttta tcatgaaact     2040

gcctcataaa tttgacaccc tggttggaga gagaggggcc cagttgagtg gtgggcagaa     2100

gcagaggatc gccattgcac gtgccctggt tcgcaacccc aagatcctcc tgctggatga     2160

ggccacgtca gccttggaca cagaaagcga agcagtggtt caggtggctc tggataaggc     2220

cagaaaaggt cggaccacca ttgtgatagc tcatcgtttg tctacagttc gtaatgctga     2280

cgtcatcgct ggtttcgatg atggagtcat tgtggagaaa ggaaatcatg atgaactcat     2340

gaaagagaaa ggcatttact tcaaacttgt cacaatgcag acagcaggaa atgaagttga     2400

attagaaaat gcagctgatg aatccaaaag tgaaattgat gccttggaaa tgtcttcaaa     2460

tgattcaaga tccagtctaa taagaaaaag atcaactcgt aggagtgtcc gtggatcaca     2520

agcccaagac agaaagctta gtaccaaaga ggctctggat gaaagtatac ctccagtttc     2580

cttttggagg attatgaagc taaatttaac tgaatggcct tattttgttg ttggtgtatt     2640

ttgtgccatt ataaatggag gcctgcaacc agcatttgca ataatatttt caaagattat     2700

aggggttttt acaagaattg atgatcctga aacaaaacga cagaatagta acttgttttc     2760

actattgttt ctagcccttg gaattatttc ttttattaca tttttccttc agggtttcac     2820

atttggcaaa gctggagaga tcctcaccaa gcggctccga tacatggttt tccgatccat     2880

gctcagacag gatgtgagtt ggtttgatga ccctaaaaac accactggag cattgactac     2940

caggctcgcc aatgatgctg ctcaagttaa aggggctata ggttccaggc ttgctgtaat     3000

tacccagaat atagcaaatc ttgggacagg aataattata tccttcatct atggttggca     3060

actaacactg ttactcttag caattgtacc catcattgca atagcaggag ttgttgaaat     3120

gaaaatgttg tctggacaag cactgaaaga taagaaagaa ctagaaggtt ctgggaagat     3180

cgctactgaa gcaatagaaa acttccgaac cgttgtttct ttgactcagg agcagaagtt     3240

tgaacatatg tatgctcaga gtttgcaggt accatacaga aactctttga ggaaagcaca     3300

catctttgga attacatttt ccttcaccca ggcaatgatg tatttttcct atgctggatg     3360

tttccggttt ggagcctact tggtggcaca taaactcatg agctttgagg atgttctgtt     3420

agtattttca gctgttgtct ttggtgccat ggccgtgggg caagtcagtt catttgctcc     3480

tgactatgcc aaagccaaaa tatcagcagc ccacatcatc atgatcattg aaaaaacccc     3540

tttgattgac agctacagca cggaaggcct aatgccgaac acattggaag gaaatgtcac     3600

atttggtgaa gttgtattca actatcccac ccgaccggac atcccagtgc ttcagggact     3660

gagcctggag gtgaagaagg gccagacgct ggctctggtg ggcagcagtg gctgtgggaa     3720

gagcacagtg gtccagctcc tggagcggtt ctacgacccc ttggcaggga aagtgctgct     3780

tgatggcaaa gaaataaagc gactgaatgt tcagtggctc cgagcacacc tgggcatcgt     3840

gtcccaggag cccatcctgt ttgactgcag cattgctgag aacattgcct atggagacaa     3900

cagccgggtg gtgtcacagg aagagattgt gagggcagca aaggaggcca acatacatgc     3960

cttcatcgag tcactgccta ataaatatag cactaaagta ggagacaaag gaactcagct     4020

ctctggtggc cagaaacaac gcattgccat agctcgtgcc cttgttagac agcctcatat     4080

tttgcttttg gatgaagcca cgtcagctct ggatacagaa agtgaaaagg ttgtccaaga     4140

agccctggac aaagccagag aaggccgcac ctgcattgtg attgctcacc gcctgtccac     4200

catccagaat gcagacttaa tagtggtgtt tcagaatggc agagtcaagg agcatggcac     4260

gcatcagcag ctgctggcac agaaaggcat ctatttttca atggtcagtg tccaggctgg     4320

aacaaagcgc cagtgaactc tgactgtatg agatgttaaa tactttttaa tatttgttta     4380

gatatgacat ttattcaaag ttaaaagcaa acacttacag aattatgaag aggtatctgt     4440

ttaacatttc ctcagtcaag ttcagagtct tcagagactt cgtaattaaa ggaacagagt     4500

gagagacatc atcaagtgga gagaaatcat agtttaaact gcattataaa ttttataaca     4560

gaattaaagt agattttaaa agataaaatg tgtaattttg tttatatttt cccatttgga     4620

ctgtaactga ctgccttgct aaaagattat agaagtagca aaaagtattg aaatgtttgc     4680

ataaagtgtc tataataaaa ctaaactttc atgtgaaa                             4718


<210>  4
<211>  2216
<212>  DNA
<213>  Rattus norvegicus

<400>  4
tgcaagatgg gtgtctaccg catccgcgtc tccaccggag actccaagta cgcgggctcc       60

aacaacgagg tctacctgtg gttggttgga cagcatggag aggcatctct cgggaagctg      120

ctacgaccct gtcgggactc ggaagcagaa ttcaaagtgg atgtgtcagg ataccttggg      180

ccactgctgt tcgtaagagt gcagaaatgg cattatctca cggatgacgc ctggttctgc      240

aactggattt ctgtgaaggg ccccggagac caaggatcag agtacatgtt cccctgttac      300

cgatgggttc agggcagaag catcctgagc ctccctgagg gcactggctg caccgtggtt      360

gaagattctc aaggactgtt caggaaacat agggaagagg agcttgaaga gaggaggagt      420

ctgtacaggt ggggcaactg gaaggatggc tcaatcctga atgtggcggc ggccagtata      480

tctgacctcc ctgtagacca acgatttcga gaggacaaaa gaattgaatt tgaagcttca      540

caggttatag gggtaatgga tactgttgtc aactttccta taaacactgt gacctgctgg      600

aaaagcctag atgacttcaa ctgcgttttc aagagtggcc ataccaaaat ggctgagcgg      660

gttcgaaact cctggaagga agatgcgttc tttgggtacc aattcctcaa tggtgctaac      720

cccatggtgc tgaagcgctc tacttgtctt cctgcccgcc tggtattccc tccaggaatg      780

gagaagctac aggcccagct gaacaaggag ctccagaaag gcactctgtt tgaagcggat      840

ttcttccttc tggatgggat caaggccaat gtcatccttt gtagccagca gtacctggct      900

gcccctctcg tcatgctgaa gctgatgcct gatggacaac tcttgcccat agccatccag      960

cttgaacttc ccaaaactgg gtctactcca ccacctattt tcacgccctc ggatccccca     1020

atggactggc tcctagccaa atgctgggtc cggagctccg acttacagct ccatgagctg     1080

caggctcatc ttctgagggg acacttgatg gctgaggtct ttgctgtggc caccatgagg     1140

tgcctgcctt ccgtgcaccc tgtttttaag cttctagttc ctcatctgct ttacaccatg     1200

gaaattaatg tccgggccag gagtgacctg atctcagaga gaggcttttt tgacaaggca     1260

atgagcacag gtgggggagg ccacctggat cttctcaagc aagctggagc ctttctgacc     1320

tattgctcat tgtgtccccc cgatgacttg gctgagcgag gactcttgga tatcgagact     1380

tgcttctatg ctaaagacgc cctgcgactc tggcagatca tgaatcggta cgtggtggga     1440

atgttcaatc tccactacaa gaccgacaaa gctgtgcaag acgactatga actgcagagc     1500

tggtgtcgag agatcactga cattggtctt caaggggccc aggacagagg cttccctacc     1560

tctcttcagt cccgggctca ggcttgctac ttcatcacca tgtgcatctt cacgtgcacc     1620

gcacagcact cttccgtcca tcttggccag ctggattggt tctactgggt tcctaatgca     1680

ccctgcacca tgcggctgcc accacccacc accaaggaag caacaatgga gaagctgatg     1740

gctacactgc ccaaccctaa tcagtctact ctccagataa atgtcgtttg gctcctgggc     1800

agacgccagg ctgttatggt gcccctgggc cagcattcag aggaacactt tccaaaccct     1860

gaggccaagg ctgtgctgaa gaagttcaga gaggaactgg ctgccttgga taaggaaatt     1920

gagattcgta ataagagctt ggacatacct tatgagtacc tgcggcccag catggtggaa     1980

aacagcgtgg ccatatgagc atccccagac tcctgctttg ttgtttagtt aagaccaccc     2040

aagtacatcc ctgtgcttga gtggtggcag tcctgccctc ccaagccccg ccctctgacc     2100

ctcaaagccc caccccctgc ccatgtggga ccctcctcca agctgtccat tgtctgctgc     2160

aatgaataca ttttgctttg gatgcattaa aaaaaaaaaa aaaaaaaaaa aaaaaa         2216


<210>  5
<211>  2105
<212>  DNA
<213>  Homo sapiens

<400>  5
tccgggtttt gcggcggagc gggcgggctg cgcgtgcggc ggcttcaact gtcgcggtag       60

gcagcagcag gctgaaggga tcatggtgca gtacgagctg tgggccgcgc tgcctggcgc      120

ctccggggtc gccctggcct gctgcttcgt ggcggcggcc gtggccctgc gctggtccgg      180

gcgccggacg gcgcggggcg cggtggtccg ggcgcgacag aggcagcgag cgggcctgga      240

gaacatggac agggcggcgc agcgcttccg gctccagaac ccagacctgg actcagaggc      300

gctgctagcc ctgcccctgc ctcagctggt gcagaagtta cacagtagag agctggcccc      360

tgaggccgtg ctcttcacct atgtgggaaa ggcctgggaa gtgaacaaag ggaccaactg      420

tgtgacctcc tatctggctg actgtgagac tcagctgtct caggccccaa ggcagggcct      480

gctctatggc gtccctgtga gcctcaagga gtgcttcacc tacaagggcc aggactccac      540

gctgggcttg agcctgaatg aaggggtgcc ggcggagtgc gacagcgtag tggtgcatgt      600

gctgaagctg cagggtgccg tgcccttcgt gcacaccaat gttccacagt ccatgttcag      660

ctatgactgc agtaaccccc tctttggcca gaccgtgaac ccatggaagt cctccaaaag      720

cccagggggc tcctcagggg gtgaaggggc cctcatcggg tctggaggct cccccctggg      780

cttaggcact gatatcggag gcagcatccg cttcccctcc tccttctgcg gcatctgcgg      840

cctcaagccc acagggaacc gcctcagcaa gagtggcctg aagggctgtg tctatggaca      900

ggaggcagtg cgtctctccg tgggccccat ggcccgggac gtggagagcc tggcactgtg      960

cctgcgagcc ctgctgtgcg aggacatgtt ccgcttggac cccactgtgc ctcccttgcc     1020

cttcagagaa gaggtctaca ccagctctca gcccctgcgt gtggggtact atgagactga     1080

caactatacc atgccctccc cggccatgag gcgggccgtg ctggagacca aacagagcct     1140

tgaggctgcg gggcacacgc tggttccctt cttgccaagc aacatacccc atgctctgga     1200

gaccctgtca acaggtgggc tcttcagtga tggtggccac accttcctac agaacttcaa     1260

aggtgatttc gtggacccct gcctggggga cctggtctca attctgaagc ttccccaatg     1320

gcttaaagga ctgctggcct tcctggtgaa gcctctgctg ccaaggctgt cagctttcct     1380

cagcaacatg aagtctcgtt cggctggaaa actctgggaa ctgcagcacg agatcgaggt     1440

gtaccgcaaa accgtgattg cccagtggag ggcgctggac ctggatgtgg tgctgacccc     1500

catgctggcc cctgctctgg acttgaatgc cccaggcagg gccacagggg ccgtcagcta     1560

cactatgctg tacaactgcc tggacttccc tgcaggggtg gtgcctgtca ccacggtgac     1620

tgctgaggac gaggcccaga tggaacatta caggggctac tttggggata tctgggacaa     1680

gatgctgcag aagggcatga agaagagtgt ggggctgccg gtggccgtgc agtgtgtggc     1740

tctgccctgg caagaagagt tgtgtctgcg gttcatgcgg gaggtggagc gactgatgac     1800

ccctgaaaag cagtcatcct gatggctctg gctccagagg acctgagact cacactctct     1860

gcagcccagc ctagtcaggg cacagctgcc ctgctgccac agcaaggaaa tgtcctgcat     1920

ggggcagagg cttccgtgtc ctctccccca accccctgca agaagcgccg actccctgag     1980

tctggacctc catccctgct ctggtcccct ctcttcgtcc tgatccctcc acccccatgt     2040

ggcagcccat gggtatgaca taggccaagg cccaactaac agtcaagaaa cagctaaaaa     2100

aaaaa                                                                 2105


<210>  6
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
tttcttggat tatgccgggt a                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gttggcaagc tttgacaaca ct                                                22


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
aaacaccaaa gatgatatt                                                    19


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
aacaccaata atattttc                                                     18


