                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
       Iowa State University Research Foundation, Inc.
 
<120>  MATERIALS AND METHODS FOR EFFICIENT TARGETED KNOCK IN OR GENE 
       REPLACEMENT

<130>  07039-1713WO1

<150>  US 62/531,673
<151>  2017-07-12

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = a, c, g, or t

<400>  1
nnncaaacgc ctgtctcctg ctctgcgctc cc                                     32


<210>  2
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<220>
<221>  misc_feature
<222>  (30)..(32)
<223>  n = a, c, g, or t

<400>  2
gggagcgcag agcaggagac aggcgtttgn nn                                     32


<210>  3
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  n = a, c, g, or t

<400>  3
gggagcgcag agcaggagac aggnnncaaa cgcctgtc                               38


<210>  4
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  n = a, c, g, or t

<400>  4
gacaggcgtt tgnnncctgt ctcctgctct gcgctccc                               38


<210>  5
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  n = a, c, g, or t

<400>  5
nnncaaacgc ctgtctcctg ctctgcgctc nnn                                    33


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  n = a, c, g, or t

<400>  6
nnngagcgca gagcaggaga caggcgtttg nnn                                    33


<210>  7
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  n = a, c, g, or t

<400>  7
gggaggcgtt cgggccacag cggnnncaaa cgcctgtc                               38


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  n = a, c, g, or t

<400>  8
gacaggcgtt tgnnnccgct gtggcccgaa cgcctccc                               38


<210>  9
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  n = a, c, g, or t

<400>  9
tcctgctctg cgctgnnncc gctgtggccc gaacgcctcc c                           41


<210>  10
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  n = a, c, g, or t

<400>  10
gggaggcgtt cgggccacag cggnnncagc gcagagcagg a                           41


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = a, c, g, or t

<400>  11
nnncaaacgc ctgtc                                                        15


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = a, c, g, or t

<400>  12
nnngagcgca gagcagga                                                     18


<210>  13
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
gggaggcgtt cgggcca                                                      17


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  n = a, c, g, or t

<400>  14
gacaggcgtt tgnnnccgct g                                                 21


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  n = a, c, g, or t

<400>  15
tcctgctctg cgctgnnncc gctg                                              24


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
gggaggcgtt cgggcca                                                      17


<210>  17
<211>  65
<212>  DNA
<213>  Danio rerio

<400>  17
agagaacgaa caaacgcgta ccggagcata accaaccaaa cgcctgtctc cagctctgcg       60

ctccc                                                                   65


<210>  18
<211>  65
<212>  DNA
<213>  Danio rerio

<400>  18
gggagcgcag agctggagac aggcgtttgg ttggttatgc tccggtacgc gtttgttcgt       60

tctct                                                                   65


<210>  19
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
gggagcgcag agctggagac aggaaaagag aacgaacaaa cgcgtaccgg agcataacca       60

accaaacgcc tgtc                                                         74


<210>  20
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
gacaggcgtt tggttggtta tgctccggta cgcgtttgtt cgttctcttt tcctgtctcc       60

agctctgcgc tccc                                                         74


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
accaaccaaa cgcctgtcgg atcc                                              24


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
accaaccaaa cgcctgtcag gatcc                                             25


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
taccggagca taaccaacca aacgcctgtc ggatcc                                 36


<210>  24
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
taccggagca taaccaacca aacgcctgtc taggagcata accaaccaaa cgcctgtcgg       60

atcc                                                                    64


<210>  25
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
gagatgagag aacgaacaaa cgcgtaccgg agcataacca accaaacgcc tgtcggatcc       60


<210>  26
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
gagatgagag aagagaacaa acgcgtaccg gagcataacc aaccaaacgc ctgtcggatc       60

c                                                                       61


<210>  27
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  27
gagatgagag aacgaacaaa cgcgtaccgg agcataacca accaaacgcc tgtcggattc       60


<210>  28
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  28
gggaggcguu cgggccacag cgg                                               23


<210>  29
<211>  38
<212>  DNA
<213>  Danio rerio

<400>  29
acggatcgga tctgagtcgg gatagcttgg attgctac                               38


<210>  30
<211>  38
<212>  DNA
<213>  Danio rerio

<400>  30
gtagcaatcc aagctatccc gactcagatc cgatccgt                               38


<210>  31
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  31
gggaggcgtt cgggccacag cggacggatc ggatctgagt cgggata                     47


<210>  32
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  32
tatcccgact cagatccgat ccgtccgctg tggcccgaac gcctccc                     47


<210>  33
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  33
tccagctctg cgctcccgct tattatctgc tctccaactc act                         43


<210>  34
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  34
tccagctctg cgctcccgct tattccgctt atctgctctc caactcact                   49


<210>  35
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  35
acaacgacgg atacttcatg gtgcccttca ttggatcc                               38


<210>  36
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  36
acaacgacgg atacttcatg gtgcccttca ttggaccc                               38


<210>  37
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  37
acaacgacgg atacttcatg gtgcccttca ttggatcc                               38


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  38
ccatggtccc tctctacagg aacggagact attttc                                 36


<210>  39
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  39
cttatgaaaa tgtggatgtg atccaaggga ttggatcc                               38


<210>  40
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  40
cttatgaaaa tgtggttgtg atccaaggga ttggatcc                               38


<210>  41
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  41
gataagaaaa tgtggttgtg atccaaggga ttggatcc                               38


<210>  42
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  42
ccatggagat ggtggtgctg caggcgtcat attcga                                 36


<210>  43
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  43
ccatggagat ggtggtgctg caggcttcat attcga                                 36


<210>  44
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  44
ccatggagat ggtggtgctg caggcttcat gaaggtgctg caggcttcat attcga           56


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  45
gggaggcgtt cgggccacag cgg                                               23


<210>  46
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  n = a, c, g, or t

<400>  46
taatacgact cactataggn nnnnnnnnnn nnnnnnngtt ttagagctag aaatagc          57


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(22)
<223>  n = a, c, g, or t

<400>  47
ggnnnnnnnn nnnnnnnnnn nn                                                22


<210>  48
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  48
taatacgact cactata                                                      17


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  49
gttttagagc tagaaatagc                                                   20


<210>  50
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  50
gatccgcacc gactcggtgc cactttttca agttgataac ggactagcct tattttaact       60

tgctatttct agctctaaaa c                                                 81


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  51
gatccgcacc gactcggtg                                                    19


<210>  52
<211>  190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  52
cggcctcggg atccaccggc cagaatcgat atactacgat gaacagagca aatttgtgtg       60

taatacggtc gccaccatgg cctcctcggt ttgctacgat gcatttgcac cactctctca      120

tgtccggttc tgggaggacg tcatcaagga gttcatgcgc ttcaaggtgc gcatggaggg      180

ctccgtgaac                                                             190


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  53
ggcgttgtct agcaaggaag                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  54
atggctcata acaccccttg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  55
gcatggatgt tttcccagtc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  56
atggctcata acaccccttg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  57
gggaggcgtt cgggccacag                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  58
gggaggcgtt cgggccacag                                                   20


<210>  59
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  59
gggaggcguu cgggccacag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcggau c                          101


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  60
gccttgattc cacttctgtc a                                                 21


<210>  61
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  61
ccttaatcag ttcctcgccc ttaga                                             25


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  62
gctgaacttg tggccgttta                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  63
gcaaacggcc ttaactttcc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  64
ctacggcgct ctggatatgt                                                   20


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  65
cgacctccct agcaaactgg gg                                                22


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  66
acatggtcct gctggagttc                                                   20


<210>  67
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  67
gggagcgcag agctggagac agg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  68
gggagcgcag agctggagac agg                                               23


<210>  69
<211>  12
<212>  DNA
<213>  Danio rerio

<400>  69
caaacgcctg tc                                                           12


<210>  70
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  70
agcataacca accaaacgcc tgtc                                              24


<210>  71
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  71
agagaacgaa caaacgcgta ccggagcata accaaccaaa cgcctgtc                    48


<210>  72
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  72
gactggagaa agagttcgcg cgg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  73
gactggagaa agagttcgcg cgg                                               23


<210>  74
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  74
ctgtccagac tggagaaaga gttc                                              24


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  75
gggaggcgtt cgggccacag cgg                                               23


<210>  76
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  76
tccagctctg cgctcccgct tatt                                              24


<210>  77
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  77
tccagctctg cgctcccgct tatttactcg cagatgccac acttcgcg                    48


<210>  78
<211>  47
<212>  DNA
<213>  Danio rerio

<400>  78
gagaacgaac aaacgcgtac cggagcataa ccaaccaaac gcctgtc                     47


<210>  79
<211>  49
<212>  DNA
<213>  Danio rerio

<400>  79
gagagaacga acaaacgcgt accggagcat aaccaaccaa acgcctgtc                   49


<210>  80
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  80
gagccatatc ttgcccacga agg                                               23


<210>  81
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  81
aaatctccaa ccactccacc ttcg                                              24


<210>  82
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  82
tgggcaagat atggctcacg ttat                                              24


<210>  83
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  83
gttttcttac gcggttgttg gatgaaatct ccaaccactc caccttcg                    48


<210>  84
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  84
tgggcaagat atggctcacg ttattcatca tcttccgcat tgttttga                    48


<210>  85
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  85
gttcctgtag agagggatga agg                                               23


<210>  86
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  86
acggatactt catggtgccc ttca                                              24


<210>  87
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  87
tccctctcta caggaacgga gact                                              24


<210>  88
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  88
ggagagggag atcagatcga tgg                                               23


<210>  89
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  89
gtcacagcag agttcacttt agg                                               23


<210>  90
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  90
gctccagtcc actaactcca tctgtgatca tgcatggaga atatggga                    48


<210>  91
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  91
acccgcctag agaacaaata cgatgtgact ttggccctct accaaaga                    48


<210>  92
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  92
gtcaaagcgc agcctcttca ggg                                               23


<210>  93
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  93
atggacggac aagatgaagc agacggaagg tgggagtcat gatcagtt                    48


<210>  94
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  94
gtttccctgt ggtgctgggt tgg                                               23


<210>  95
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  95
gtctggcacg aggagcacaa ggg                                               23


<210>  96
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  96
tgttcgtgtg actacaatgg atgccgagct ggagtttgcc atccaacc                    48


<210>  97
<211>  48
<212>  DNA
<213>  Danio rerio

<400>  97
caagggcatg ttgaggtaca gacaatggaa tgtgctcttg ctattttt                    48


<210>  98
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  98
ggatgtgatc caagggaaga tgg                                               23


<210>  99
<211>  24
<212>  DNA
<213>  Danio rerio

<400>  99
aaaatgtgga tgtgatccaa ggga                                              24


<210>  100
<211>  23
<212>  DNA
<213>  Danio rerio

<400>  100
agatggtggt gctgcaggct tca                                               23


<210>  101
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  101
gctttttgga ctaaacagac gccatg                                            26


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  102
cttgtgcgta cacagctcca cg                                                22


<210>  103
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  103
cgatgttata cttgcttctt tttagttttg tacatat                                37


<210>  104
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  104
catctttgag cagtggttga ggaga                                             25


<210>  105
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  105
cacctggatc ctgtaaatat gcatattcat atc                                    33


<210>  106
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  106
ggtctttcag tcagcgagtt taatgtc                                           27


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  107
catttcagtg ctggtagcag actg                                              24


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  108
gcaggactga gacggtggta                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  109
caaatgcatc gtagcaaacg                                                   20


<210>  110
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  110
aaggacaagg atcctgagtt tg                                                22


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  111
gctttgcatc acaacctcaa                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  112
agccagcttc tggatcagtg                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  113
ggggaggtgt gggaggtttt                                                   20


<210>  114
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  114
ttccttcatt cattcattga ca                                                22


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  115
cgtgtgattg acagggtcac                                                   20


<210>  116
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  116
cagatgccac acttcgcgt                                                    19


<210>  117
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  117
cgatgttata cttgcttctt tttagttttg tacatat                                37


<210>  118
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  118
gttttgctaa tcctgagacg ggtttg                                            26


<210>  119
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  119
ctgtcaataa aagcatgatg tatgatgaaa atgg                                   34


<210>  120
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  120
atcatctcat tcgtcaatgg agacttcag                                         29


<210>  121
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  121
cacagtgtgg cagtgagcat tc                                                22


<210>  122
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  122
ctgaagaaca actgggagtg tcgc                                              24


<210>  123
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  123
ttacatatcc agagcgccgt aggg                                              24


<210>  124
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  124
atggtgtcta agggcgaaga gc                                                22


<210>  125
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  125
agcttcaggg ccatgtcgc                                                    19


<210>  126
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  126
ggatccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga agaaaacccc       60

ggtccttcta gaaagctact gtcttctatc gaacaagca                              99


<210>  127
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  127
gcatccatgg taatttattt agcagtagat agctatattg tgtgaaacgc                  50


<210>  128
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  128
agacatacta gtatggtgag caagggcgag gagctg                                 36


<210>  129
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  129
tggatcctcg agttacttgt acagctcgt                                         29


<210>  130
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  130
cgctgcctcg agggcgcgcc tctagaacta tag                                    33


<210>  131
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  131
agccatacta gtaggaccgg ggttttctt                                         29


<210>  132
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  132
tgatacacgc aggtgcgcaa cgcaattaat gtgagtt                                37


<210>  133
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  133
atcctgtggc aggtccattc gccattcagg ctgc                                   34


<210>  134
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide)

<400>  134
gggaggcgtt cgggccacag cggacacgca ggtgcgcaac gcaattaatg                  50


<210>  135
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  135
ctgatcggat cctgtggcag gtccattcg                                         29


<210>  136
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  136
gtacatgaat tcgggaggcg ttcgggccac ag                                     32


<210>  137
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  137
cgttgtctag caaggaagtg aaga                                              24


<210>  138
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  138
gggaggcgtt cgggccacag cggagaagag catattcaat gtcg                        44


<210>  139
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide)

<400>  139
tgcagccatg gcgttgtcta gcaaggaagt gaaga                                  35


<210>  140
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  140
tcgagcggcc gagatcccat cgctagcggg                                        30


<210>  141
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  141
cttaatcagt tcctcgccct tag                                               23


<210>  142
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  142
gagaacatgc acatgaagct gtac                                              24


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  143
aatacgcaaa ccgcctctcc                                                   20


<210>  144
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  144
gggcgcacat ccgcttc                                                      17


<210>  145
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  145
tttaaaagtc aaaccaccat gactg                                             25


<210>  146
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  146
ctggcagttc cttcctgtta a                                                 21


<210>  147
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  147
atatgtggcg cgccacggac tgttaccact tcacg                                  35


<210>  148
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  148
acaacgccat ggtaatttat ttagc                                             25


<210>  149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  149
acagatctct cgagccgccc c                                                 21


<210>  150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  150
attcccgggg tcgacctcga                                                   20


<210>  151
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  151
ggagagagct gcacaagagg gc                                                22


<210>  152
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  152
gatatcgcta gcaccggtgc ggccgcgttt aaacactagt cccgggggac aacgcccaag       60

aatcag                                                                  66


<210>  153
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  153
cccgggacta gtgtttaaac gcggccgcac cggtgctagc gatatctgca ggggattgag       60

caggtg                                                                  66


<210>  154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  154
agcattacgg caactgagct                                                   20


<210>  155
<211>  4104
<212>  DNA
<213>  Streptococcus pyogenes

<400>  155
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg attataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg gcagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggcag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa atctacaatc aattatttga agaaaaccct      600

attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga gaaatggctt gtttgggaat      720

ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca      960

atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgagggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggcgcct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agataggggg atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg ccatagttta     2160

catgaacaga ttgctaactt agctggcagt cctgctatta aaaaaggtat tttacagact     2220

gtaaaaattg ttgatgaact ggtcaaagta atggggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctacaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt     2520

gttccacaaa gtttcattaa agacgattca atagacaata aggtactaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga ctga                                            4104


<210>  156
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  156

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Ser Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


