                               SEQUENCE LISTING

<110> REFUGE BIOTECHNOLOGIES, INC.
 
<120> METHODS AND SYSTEMS FOR CONDITIONALLY REGULATING GENE EXPRESSION

<130> 50489-707.601

<140> PCT/US2018/041704
<141> 2018-07-11

<150> 62/587,668
<151> 2017-11-17

<150> 62/531,752
<151> 2017-07-12

<160> 37    

<170> PatentIn version 3.5

<210> 1
<211> 18
<212> PRT
<213> Thosea asigna virus

<400> 1
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 2
<211> 19
<212> PRT
<213> Porcine teschovirus-1

<400> 2
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 3
<211> 20
<212> PRT
<213> Equine rhinitis A virus

<400> 3
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 4
<211> 22
<212> PRT
<213> Foot-and-mouth disease virus

<400> 4
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Glu Thr Gln Arg Cys Thr Trp His Met Gly Glu Leu Val Trp Cys Glu 
1               5                   10                  15      


Arg Glu His Asn 
            20  


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Lys Glu Ala Ser Cys Ser Tyr Trp Leu Gly Glu Leu Val Trp Cys Val 
1               5                   10                  15      


Ala Gly Val Glu 
            20  


<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 8
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(50)
<223> This sequence may encompass 3-50 residues

<400> 8
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   


<210> 11
<211> 7
<212> PRT
<213> Simian virus 40

<400> 11
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 12
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Nucleoplasmin bipartite NLS sequence

<400> 12
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 13
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      C-myc NLS sequence

<400> 13
Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210> 14
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      C-myc NLS sequence

<400> 14
Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210> 15
<211> 38
<212> PRT
<213> Homo sapiens

<400> 15
Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210> 16
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      IBB domain from importin-alpha sequence

<400> 16
Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210> 17
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Myoma T protein sequence

<400> 17
Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210> 18
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Myoma T protein sequence

<400> 18
Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens

<400> 19
Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210> 20
<211> 12
<212> PRT
<213> Mus musculus

<400> 20
Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210> 21
<211> 5
<212> PRT
<213> Influenza virus

<400> 21
Asp Arg Leu Arg Arg 
1               5   


<210> 22
<211> 7
<212> PRT
<213> Influenza virus

<400> 22
Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210> 23
<211> 10
<212> PRT
<213> Hepatitis delta virus

<400> 23
Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210> 24
<211> 10
<212> PRT
<213> Mus musculus

<400> 24
Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210> 25
<211> 20
<212> PRT
<213> Homo sapiens

<400> 25
Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210> 26
<211> 17
<212> PRT
<213> Homo sapiens

<400> 26
Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210> 27
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Dual acylation region sequence


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 27
Met Gly Cys Xaa Cys 
1               5   


<210> 28
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-10 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 28
Ile Glu Ala Asp Xaa 
1               5   


<210> 29
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-2 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 29
Asp Val Ala Asp Xaa 
1               5   


<210> 30
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-2 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 30
Asp Glu His Asp Xaa 
1               5   


<210> 31
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-3 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 31
Asp Met Gln Asp Xaa 
1               5   


<210> 32
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-3 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 32
Asp Glu Val Asp Xaa 
1               5   


<210> 33
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-4 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 33
Leu Glu Val Asp Xaa 
1               5   


<210> 34
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-7 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid except Asp, Glu, Lys, Pro, Gln or Arg

<400> 34
Asp Glu Val Asp Xaa 
1               5   


<210> 35
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-9 recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 35
Leu Glu His Asp Xaa 
1               5   


<210> 36
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Granzyme B recognition sequence


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 36
Ile Glu Pro Asp Xaa 
1               5   


<210> 37
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      HRV3C protease recognition sequence

<400> 37
Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


