                         SEQUENCE LISTING

<110>  National Research Council of Canada
       Tanha, Jamshid
       Hussack, Greg
       Sulea, Traian
       Purisima, Enrico  O.
 
<120>  Clostridium Difficile-Specific Antibodies and Uses Thereof

<130>  2018-006-02

<140>  PCT/IB2018/055047
<141>  2018-07-09

<150>  US 62/531,009
<151>  2017-07-11

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (A26.8-generic or variant)

<400>  1

Glu Arg Thr Phe Ser Arg Tyr Pro 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (A26.8-generic)


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  is T or R

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  is T, R or I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  is T or K

<400>  2

Ile Ser Ser Xaa Gly Xaa Ser Xaa 
1               5               


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (A26.8-generic)


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  is Q or K

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  is T, R, K, M or W

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  is N or R

<400>  3

Ala Val Asn Ser Xaa Arg Xaa Arg Leu Gln Asp Pro Xaa Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (A26.8 or variant)

<400>  4

Ile Ser Ser Thr Gly Thr Ser Thr 
1               5               


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (A26.8 or variant)

<400>  5

Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (A26.8 or variant)

<400>  6

Ile Ser Ser Arg Gly Thr Ser Thr 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 A26.8-T56R

<400>  7

Ile Ser Ser Thr Gly Arg Ser Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 A26.8-T56I

<400>  8

Ile Ser Ser Thr Gly Ile Ser Thr 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 A26.8-T58K

<400>  9

Ile Ser Ser Thr Gly Thr Ser Lys 
1               5               


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  10

Ala Val Asn Ser Lys Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  11

Ala Val Asn Ser Gln Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  12

Ala Val Asn Ser Gln Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  13

Ala Val Asn Ser Gln Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8-T103W

<400>  14

Ala Val Asn Ser Gln Arg Trp Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8-N109R

<400>  15

Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Arg Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  16

Ala Val Asn Ser Lys Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  17

Ala Val Asn Ser Lys Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 A26.8 variant

<400>  18

Ala Val Asn Ser Lys Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-generic


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  is T or R

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  is T, R or I

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  is T or K

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  is Q or K

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  is T, R, K, M or W

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  is N or R

<400>  19

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Xaa Gly Xaa Ser Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Xaa Arg Xaa Arg Leu Gln Asp Pro Xaa Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  20
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-wild-type

<400>  20

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  21
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T54R

<400>  21

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Arg Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R

<400>  22

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56I

<400>  23

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T58K

<400>  24

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Lys Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  25
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-Q101K

<400>  25

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T103R

<400>  26

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T103K

<400>  27

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T103M

<400>  28

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  29
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T103W

<400>  29

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Trp Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  30
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-N109R

<400>  30

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Thr Arg Leu Gln Asp Pro Arg Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,Q101K

<400>  31

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Thr Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,T103R

<400>  32

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,T103K

<400>  33

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  34
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,T103M

<400>  34

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Gln Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  35
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-Q101K,T103R

<400>  35

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  36
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-Q101K,T103K

<400>  36

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  37
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-Q101K,T103M

<400>  37

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  38
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,Q101K,T103R

<400>  38

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Arg Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  39
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,Q101K,T103K

<400>  39

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Lys Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  40
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26.8-T56R,Q101K,T103M

<400>  40

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Val Ala Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Ser Thr Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Val Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Arg Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Val Asn Ser Lys Arg Met Arg Leu Gln Asp Pro Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


