                         SEQUENCE LISTING

<110>  UNIVERSITAT AUTNOMA DE BARCELONA
       FUNDACI INSTITUT DE RECERCA DE L' HOSPITAL DE LA SANTA 
       CREU I SANT PAU
       CENTRO DE INVESTIGACIN BIOMDICA EN RED
 
<120>  THERAPEUTIC NANOCONJUGATES AND USES THEREOF

<130>  P14353PC00

<150>  EP17382461.6
<151>  2017-07-14

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polycationic peptide

<400>  1

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polycationic peptide

<400>  2

Arg Arg Arg Gly Arg Gly Arg Arg Arg 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polycationic peptide

<400>  3

Arg Ala Arg Gly Arg Gly Arg Arg Arg 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polycationic peptide

<400>  4

Arg Ala Arg Gly Arg Gly Gly Gly Ala 
1               5                   


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T22 peptide

<400>  5

Arg Arg Trp Cys Tyr Arg Lys Cys Tyr Lys Gly Tyr Cys Tyr Arg Lys 
1               5                   10                  15      


Cys Arg 
        


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V1 peptide

<400>  6

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro 
            20      


<210>  7
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12 peptide

<400>  7

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn 
65          


<210>  8
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vCCL2 peptide

<400>  8

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro Thr Ser 
            20                  25                  30          


Gln Leu Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Gly Arg 
        35                  40                  45              


Gln Val Cys Ala Asp Lys Asp Trp Val Lys Lys Leu Met Gln Gln Leu 
    50                  55                  60                  


Pro Val Thr Ala 
65              


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T140 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-3-(2-naphthyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-Citrulline

<400>  9

Arg Arg Xaa Cys Tyr Arg Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TN14003 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-3-(2-naphthyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L-Citrulline

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Lys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-Citrulline

<400>  10

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TC 14012 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-3-(2-naphthyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Citrulline

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-Citrulline

<400>  11

Arg Arg Xaa Cys Tyr Glu Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TE14011 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa  is L-3-(2-naphthyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is  L-Citrulline

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is  L-Citrulline

<400>  12

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZ14011 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-3-(2)-naphthyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L-Citrulline

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Lysine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-Citrulline

<400>  13

Arg Arg Xaa Cys Tyr Xaa Lys Xaa Pro Tyr Arg Xaa Cys Arg 
1               5                   10                  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GW-H1 peptide

<400>  14

Gly Tyr Asn Tyr Ala Lys Lys Leu Ala Asn Leu Ala Lys Lys Phe Ala 
1               5                   10                  15      


Asn Ala Leu Trp 
            20  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A5G27

<400>  15

Arg Leu Val Ser Tyr Asn Gly Ile Ile Phe Phe Leu Lys 
1               5                   10              


<210>  16
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI/II/V

<400>  16

Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu 
1               5                   10                  15      


Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly 
            20                  25                  30          


Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr 
        35                  40                  45              


Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile 
    50                  55                  60                  


Gly Arg Lys Lys Thr 
65                  


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq-1-7 peptide

<400>  17

Lys Tyr Leu Ala Tyr Pro Asp Ser Val His Ile Trp Arg Lys Arg Lys 
1               5                   10                  15      


Arg Lys 
        


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq-1-8 peptide

<400>  18

Lys Tyr Leu Ala Tyr Pro Asp Ser Val His Ile Trp Arg Lys Arg Lys 
1               5                   10                  15      


Arg Lys Arg 
            


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiopep-2-7 peptide

<400>  19

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr Arg Lys Arg 
            20          


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleolin binding peptide

<400>  20

Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Ala 
1               5                   10                  15      


Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys 
            20                  25                  30      


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleolin binding peptide

<400>  21

Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Ala 
1               5                   10                  15      


Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys Arg 
            20                  25                  30          


Lys Arg Lys Arg Lys Arg Lys 
        35                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker/spacer

<400>  22

Ser Gly Gly Thr Ser Gly Ser Thr Ser Gly Thr Gly Ser Thr 
1               5                   10                  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker/spacer

<400>  23

Ala Gly Ser Ser Thr Gly Ser Ser Thr Gly Pro Gly Ser Thr Thr 
1               5                   10                  15  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker/spacer

<400>  24

Gly Gly Ser Gly Gly Ala Pro 
1               5           


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker/spacer

<400>  25

Gly Gly Gly Val Glu Gly Gly Gly 
1               5               


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10 amino acid residues of the upper hinge region of murine IgG3

<400>  26

Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
1               5                   10  


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker/spacer

<400>  27

Ala Pro Ala Glu Thr Lys Ala Glu Pro Met Thr 
1               5                   10      


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  28

Asp Asp Asp Asp Lys 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  29

Ile Glu Asp Gly Arg 
1               5   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  30

Leu Val Pro Arg Gly Ser 
1               5       


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  31

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  32

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   linker

<400>  33

Gly Gly Ser Ser Arg Ser Ser 
1               5           


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   linker

<400>  34

Gly Gly Gly Asn Ser 
1               5   


<210>  35
<211>  238
<212>  PRT
<213>  Aequorea victoria

<400>  35

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  36
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  37
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Val 
705                 710                 715                 720 


Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly Thr Phe Arg Cys 
                725                 730                 735     


Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly Thr Cys Val Ala 
            740                 745                 750         


Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn 
        755                 760                 765             


Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser 
    770                 775                 780                 


Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys 
785                 790                 795                 800 


Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe 
                805                 810                 815     


Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr 
            820                 825                 830         


Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        835                 840                 845             


Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
    850                 855                 860                 


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
865                 870                 875                 880 


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
                885                 890                 895     


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
            900                 905                 910         


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
        915                 920                 925             


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr 
    930                 935                 940                 


His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu 
945                 950                 955                 960 


Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro 
                965                 970                 975     


Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val 
            980                 985                 990         


Tyr Trp Thr Asp Ile Thr Glu Pro  Ser Ile Gly Arg Ala  Ser Leu His 
        995                 1000                 1005             


Gly Gly  Glu Pro Thr Thr Ile  Ile Arg Gln Asp Leu  Gly Ser Pro 
    1010                 1015                 1020             


Glu Gly  Ile Ala Val Asp His  Leu Gly Arg Asn Ile  Phe Trp Thr 
    1025                 1030                 1035             


Asp Ser  Asn Leu Asp Arg Ile  Glu Val Ala Lys Leu  Asp Gly Thr 
    1040                 1045                 1050             


Gln Arg  Arg Val Leu Phe Glu  Thr Asp Leu Val Asn  Pro Arg Gly 
    1055                 1060                 1065             


Ile Val  Thr Asp Ser Val Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1070                 1075                 1080             


Asn Arg  Asp Asn Pro Lys Ile  Glu Thr Ser Tyr Met  Asp Gly Thr 
    1085                 1090                 1095             


Asn Arg  Arg Ile Leu Val Gln  Asp Asp Leu Gly Leu  Pro Asn Gly 
    1100                 1105                 1110             


Leu Thr  Phe Asp Ala Phe Ser  Ser Gln Leu Cys Trp  Val Asp Ala 
    1115                 1120                 1125             


Gly Thr  Asn Arg Ala Glu Cys  Leu Asn Pro Ser Gln  Pro Ser Arg 
    1130                 1135                 1140             


Arg Lys  Ala Leu Glu Gly Leu  Gln Tyr Pro Phe Ala  Val Thr Ser 
    1145                 1150                 1155             


Tyr Gly  Lys Asn Leu Tyr Phe  Thr Asp Trp Lys Met  Asn Ser Val 
    1160                 1165                 1170             


Val Ala  Leu Asp Leu Ala Ile  Ser Lys Glu Thr Asp  Ala Phe Gln 
    1175                 1180                 1185             


Pro His  Lys Gln Thr Arg Leu  Tyr Gly Ile Thr Thr  Ala Leu Ser 
    1190                 1195                 1200             


Gln Cys  Pro Gln Gly His Asn  Tyr Cys Ser Val Asn  Asn Gly Gly 
    1205                 1210                 1215             


Cys Thr  His Leu Cys Leu Ala  Thr Pro Gly Ser Arg  Thr Cys Arg 
    1220                 1225                 1230             


Cys Pro  Asp Asn Thr Leu Gly  Val Asp Cys Ile Glu  Gln Lys 
    1235                 1240                 1245         


<210>  38
<211>  1375
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Gly Asp Arg Val Ala Gly Arg Pro Val Leu Ser Ser Leu Pro 
1               5                   10                  15      


Val Leu Leu Leu Leu Pro Leu Leu Met Leu Arg Ala Ala Ala Leu His 
            20                  25                  30          


Pro Asp Glu Leu Phe Pro His Gly Glu Ser Trp Gly Asp Gln Leu Leu 
        35                  40                  45              


Gln Glu Gly Asp Asp Glu Ser Ser Ala Val Val Lys Leu Ala Asn Pro 
    50                  55                  60                  


Leu His Phe Tyr Glu Ala Arg Phe Ser Asn Leu Tyr Val Gly Thr Asn 
65                  70                  75                  80  


Gly Ile Ile Ser Thr Gln Asp Phe Pro Arg Glu Thr Gln Tyr Val Asp 
                85                  90                  95      


Tyr Asp Phe Pro Thr Asp Phe Pro Ala Ile Ala Pro Phe Leu Ala Asp 
            100                 105                 110         


Ile Asp Thr Ser His Gly Arg Gly Arg Val Leu Tyr Arg Glu Asp Thr 
        115                 120                 125             


Ser Pro Ala Val Leu Gly Leu Ala Ala Arg Tyr Val Arg Ala Gly Phe 
    130                 135                 140                 


Pro Arg Ser Ala Arg Phe Thr Pro Thr His Ala Phe Leu Ala Thr Trp 
145                 150                 155                 160 


Glu Gln Val Gly Ala Tyr Glu Glu Val Lys Arg Gly Ala Leu Pro Ser 
                165                 170                 175     


Gly Glu Leu Asn Thr Phe Gln Ala Val Leu Ala Ser Asp Gly Ser Asp 
            180                 185                 190         


Ser Tyr Ala Leu Phe Leu Tyr Pro Ala Asn Gly Leu Gln Phe Leu Gly 
        195                 200                 205             


Thr Arg Pro Lys Glu Ser Tyr Asn Val Gln Leu Gln Leu Pro Ala Arg 
    210                 215                 220                 


Val Gly Phe Cys Arg Gly Glu Ala Asp Asp Leu Lys Ser Glu Gly Pro 
225                 230                 235                 240 


Tyr Phe Ser Leu Thr Ser Thr Glu Gln Ser Val Lys Asn Leu Tyr Gln 
                245                 250                 255     


Leu Ser Asn Leu Gly Ile Pro Gly Val Trp Ala Phe His Ile Gly Ser 
            260                 265                 270         


Thr Ser Pro Leu Asp Asn Val Arg Pro Ala Ala Val Gly Asp Leu Ser 
        275                 280                 285             


Ala Ala His Ser Ser Val Pro Leu Gly Arg Ser Phe Ser His Ala Thr 
    290                 295                 300                 


Ala Leu Glu Ser Asp Tyr Asn Glu Asp Asn Leu Asp Tyr Tyr Asp Val 
305                 310                 315                 320 


Asn Glu Glu Glu Ala Glu Tyr Leu Pro Gly Glu Pro Glu Glu Ala Leu 
                325                 330                 335     


Asn Gly His Ser Ser Ile Asp Val Ser Phe Gln Ser Lys Val Asp Thr 
            340                 345                 350         


Lys Pro Leu Glu Glu Ser Ser Thr Leu Asp Pro His Thr Lys Glu Gly 
        355                 360                 365             


Thr Ser Leu Gly Glu Val Gly Gly Pro Asp Leu Lys Gly Gln Val Glu 
    370                 375                 380                 


Pro Trp Asp Glu Arg Glu Thr Arg Ser Pro Ala Pro Pro Glu Val Asp 
385                 390                 395                 400 


Arg Asp Ser Leu Ala Pro Ser Trp Glu Thr Pro Pro Pro Tyr Pro Glu 
                405                 410                 415     


Asn Gly Ser Ile Gln Pro Tyr Pro Asp Gly Gly Pro Val Pro Ser Glu 
            420                 425                 430         


Met Asp Val Pro Pro Ala His Pro Glu Glu Glu Ile Val Leu Arg Ser 
        435                 440                 445             


Tyr Pro Ala Ser Gly His Thr Thr Pro Leu Ser Arg Gly Thr Tyr Glu 
    450                 455                 460                 


Val Gly Leu Glu Asp Asn Ile Gly Ser Asn Thr Glu Val Phe Thr Tyr 
465                 470                 475                 480 


Asn Ala Ala Asn Lys Glu Thr Cys Glu His Asn His Arg Gln Cys Ser 
                485                 490                 495     


Arg His Ala Phe Cys Thr Asp Tyr Ala Thr Gly Phe Cys Cys His Cys 
            500                 505                 510         


Gln Ser Lys Phe Tyr Gly Asn Gly Lys His Cys Leu Pro Glu Gly Ala 
        515                 520                 525             


Pro His Arg Val Asn Gly Lys Val Ser Gly His Leu His Val Gly His 
    530                 535                 540                 


Thr Pro Val His Phe Thr Asp Val Asp Leu His Ala Tyr Ile Val Gly 
545                 550                 555                 560 


Asn Asp Gly Arg Ala Tyr Thr Ala Ile Ser His Ile Pro Gln Pro Ala 
                565                 570                 575     


Ala Gln Ala Leu Leu Pro Leu Thr Pro Ile Gly Gly Leu Phe Gly Trp 
            580                 585                 590         


Leu Phe Ala Leu Glu Lys Pro Gly Ser Glu Asn Gly Phe Ser Leu Ala 
        595                 600                 605             


Gly Ala Ala Phe Thr His Asp Met Glu Val Thr Phe Tyr Pro Gly Glu 
    610                 615                 620                 


Glu Thr Val Arg Ile Thr Gln Thr Ala Glu Gly Leu Asp Pro Glu Asn 
625                 630                 635                 640 


Tyr Leu Ser Ile Lys Thr Asn Ile Gln Gly Gln Val Pro Tyr Val Ser 
                645                 650                 655     


Ala Asn Phe Thr Ala His Ile Ser Pro Tyr Lys Glu Leu Tyr His Tyr 
            660                 665                 670         


Ser Asp Ser Thr Val Thr Ser Thr Ser Ser Arg Asp Tyr Ser Leu Thr 
        675                 680                 685             


Phe Gly Ala Ile Asn Gln Thr Trp Ser Tyr Arg Ile His Gln Asn Ile 
    690                 695                 700                 


Thr Tyr Gln Val Cys Arg His Ala Pro Arg His Pro Ser Phe Pro Thr 
705                 710                 715                 720 


Thr Gln Gln Leu Asn Val Asp Arg Val Phe Ala Leu Tyr Asn Asp Glu 
                725                 730                 735     


Glu Arg Val Leu Arg Phe Ala Val Thr Asn Gln Ile Gly Pro Val Lys 
            740                 745                 750         


Glu Asp Ser Asp Pro Thr Pro Gly Asn Pro Cys Tyr Asp Gly Ser His 
        755                 760                 765             


Met Cys Asp Thr Thr Ala Arg Cys His Pro Gly Thr Gly Val Asp Tyr 
    770                 775                 780                 


Thr Cys Glu Cys Ala Ser Gly Tyr Gln Gly Asp Gly Arg Asn Cys Val 
785                 790                 795                 800 


Asp Glu Asn Glu Cys Ala Thr Gly Phe His Arg Cys Gly Pro Asn Ser 
                805                 810                 815     


Val Cys Ile Asn Leu Pro Gly Ser Tyr Arg Cys Glu Cys Arg Ser Gly 
            820                 825                 830         


Tyr Glu Phe Ala Asp Asp Arg His Thr Cys Ile Leu Ile Thr Pro Pro 
        835                 840                 845             


Ala Asn Pro Cys Glu Asp Gly Ser His Thr Cys Ala Pro Ala Gly Gln 
    850                 855                 860                 


Ala Arg Cys Val His His Gly Gly Ser Thr Phe Ser Cys Ala Cys Leu 
865                 870                 875                 880 


Pro Gly Tyr Ala Gly Asp Gly His Gln Cys Thr Asp Val Asp Glu Cys 
                885                 890                 895     


Ser Glu Asn Arg Cys His Pro Ala Ala Thr Cys Tyr Asn Thr Pro Gly 
            900                 905                 910         


Ser Phe Ser Cys Arg Cys Gln Pro Gly Tyr Tyr Gly Asp Gly Phe Gln 
        915                 920                 925             


Cys Ile Pro Asp Ser Thr Ser Ser Leu Thr Pro Cys Glu Gln Gln Gln 
    930                 935                 940                 


Arg His Ala Gln Ala Gln Tyr Ala Tyr Pro Gly Ala Arg Phe His Ile 
945                 950                 955                 960 


Pro Gln Cys Asp Glu Gln Gly Asn Phe Leu Pro Leu Gln Cys His Gly 
                965                 970                 975     


Ser Thr Gly Phe Cys Trp Cys Val Asp Pro Asp Gly His Glu Val Pro 
            980                 985                 990         


Gly Thr Gln Thr Pro Pro Gly Ser  Thr Pro Pro His Cys  Gly Pro Ser 
        995                 1000                 1005             


Pro Glu  Pro Thr Gln Arg Pro  Pro Thr Ile Cys Glu  Arg Trp Arg 
    1010                 1015                 1020             


Glu Asn  Leu Leu Glu His Tyr  Gly Gly Thr Pro Arg  Asp Asp Gln 
    1025                 1030                 1035             


Tyr Val  Pro Gln Cys Asp Asp  Leu Gly His Phe Ile  Pro Leu Gln 
    1040                 1045                 1050             


Cys His  Gly Lys Ser Asp Phe  Cys Trp Cys Val Asp  Lys Asp Gly 
    1055                 1060                 1065             


Arg Glu  Val Gln Gly Thr Arg  Ser Gln Pro Gly Thr  Thr Pro Ala 
    1070                 1075                 1080             


Cys Ile  Pro Thr Val Ala Pro  Pro Met Val Arg Pro  Thr Pro Arg 
    1085                 1090                 1095             


Pro Asp  Val Thr Pro Pro Ser  Val Gly Thr Phe Leu  Leu Tyr Thr 
    1100                 1105                 1110             


Gln Gly  Gln Gln Ile Gly Tyr  Leu Pro Leu Asn Gly  Thr Arg Leu 
    1115                 1120                 1125             


Gln Lys  Asp Ala Ala Lys Thr  Leu Leu Ser Leu His  Gly Ser Ile 
    1130                 1135                 1140             


Ile Val  Gly Ile Asp Tyr Asp  Cys Arg Glu Arg Met  Val Tyr Trp 
    1145                 1150                 1155             


Thr Asp  Val Ala Gly Arg Thr  Ile Ser Arg Ala Gly  Leu Glu Leu 
    1160                 1165                 1170             


Gly Ala  Glu Pro Glu Thr Ile  Val Asn Ser Gly Leu  Ile Ser Pro 
    1175                 1180                 1185             


Glu Gly  Leu Ala Ile Asp His  Ile Arg Arg Thr Met  Tyr Trp Thr 
    1190                 1195                 1200             


Asp Ser  Val Leu Asp Lys Ile  Glu Ser Ala Leu Leu  Asp Gly Ser 
    1205                 1210                 1215             


Glu Arg  Lys Val Leu Phe Tyr  Thr Asp Leu Val Asn  Pro Arg Ala 
    1220                 1225                 1230             


Ile Ala  Val Asp Pro Ile Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1235                 1240                 1245             


Asn Arg  Glu Ala Pro Lys Ile  Glu Thr Ser Ser Leu  Asp Gly Glu 
    1250                 1255                 1260             


Asn Arg  Arg Ile Leu Ile Asn  Thr Asp Ile Gly Leu  Pro Asn Gly 
    1265                 1270                 1275             


Leu Thr  Phe Asp Pro Phe Ser  Lys Leu Leu Cys Trp  Ala Asp Ala 
    1280                 1285                 1290             


Gly Thr  Lys Lys Leu Glu Cys  Thr Leu Pro Asp Gly  Thr Gly Arg 
    1295                 1300                 1305             


Arg Val  Ile Gln Asn Asn Leu  Lys Tyr Pro Phe Ser  Ile Val Ser 
    1310                 1315                 1320             


Tyr Ala  Asp His Phe Tyr His  Thr Asp Trp Arg Arg  Asp Gly Val 
    1325                 1330                 1335             


Val Ser  Val Asn Lys His Ser  Gly Gln Phe Thr Asp  Glu Tyr Leu 
    1340                 1345                 1350             


Pro Glu  Gln Arg Ser His Leu  Tyr Gly Ile Thr Ala  Val Tyr Pro 
    1355                 1360                 1365             


Tyr Cys  Pro Thr Gly Arg Lys  
    1370                 1375 


<210>  39
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  40
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  41
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys 
    210 


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BH3 domain

<400>  42

Val Gly Arg Gln Leu Ala Ile Ile Gly Asp Asp Ile Asn Arg Arg 
1               5                   10                  15  


<210>  43
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly 
1               5                   10                  15      


Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro 
            20                  25                  30          


Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro 
        35                  40                  45              


Ala Ala Pro Thr Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Thr Ala 
    50                  55                  60                  


Pro Pro Ala Val Thr Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly 
65                  70                  75                  80  


Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser 
                85                  90                  95      


Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro 
            100                 105                 110         


Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val Arg Gly 
        115                 120                 125             


Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met 
    130                 135                 140                 


Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln 
145                 150                 155                 160 


Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met 
                165                 170                 175     


Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro 
            180                 185                 190         


Asn 
    


<210>  44
<211>  187
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  44

Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala 
            180                 185         


<210>  45
<211>  209
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  45

Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
1               5                   10                  15      


Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe 
            20                  25                  30          


Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe 
        35                  40                  45              


Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly 
    50                  55                  60                  


Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp 
65                  70                  75                  80  


Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg 
                85                  90                  95      


Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu 
            100                 105                 110         


Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly 
        115                 120                 125             


His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu 
    130                 135                 140                 


Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr 
145                 150                 155                 160 


Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly 
                165                 170                 175     


Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala 
            180                 185                 190         


Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu 
        195                 200                 205             


Lys 
    


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  46

Ala Ala Ala Leu Glu 
1               5   


<210>  47
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ile Pro Trp Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Asp 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Asn Gly Pro Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  48
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ile Pro Arg Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Leu 
        35                  40                  45              


Ala Ser Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Asn Gly Pro Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Arg Ser Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  49
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ile Pro Arg Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  50
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Leu 
        35                  40                  45              


Ala Ser Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  51
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Asn Gly Pro Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Arg Ser Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  52
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Leu 
        35                  40                  45              


Ala Ser Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Asn Gly Pro Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Arg Ser Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


