                         SEQUENCE LISTING

<110>  Universitt zu Kln
 
<120>  Test for Detecting Malignant Kidney Cancer

<130>  P70952PC

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Gly Lys His Phe Ile Ser Leu 
            420                 425                 430     


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Gly Lys His Phe Ile Ser Leu 
1               5               


<210>  3
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Gly Lys Leu Thr Ile Tyr Pro His 
        275                 280                 285             


Leu Met Asp Ile Glu Leu Val Met Ile 
    290                 295         


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Lys Leu Thr Ile Tyr Pro His Leu Met Asp Ile Glu Leu Val Met 
1               5                   10                  15      


Ile 
    


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Leu Arg Gly Lys His Phe Ile Ser Leu 
1               5                   10  


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mxi-2 primer forward

<400>  6
gactcagatg ccgaagat                                                     18


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mxi-2 primer reverse

<400>  7
tcaactaatg gtactttatt tgg                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vim3 primer forward

<400>  8
gagaactttg ccgttgaagc                                                   20


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vim3 primer reverse

<400>  9
gaaataaaat gcttacccct cag                                               23


<210>  10
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  10
ttctctcacg aagccccgcc cgcggagagg ttccatattg ggtaaaatct cggctctcgg       60

agagtcccgg gagctgttct cgcgagagta ctgcgggagg ctcccgtttg ctggctcttg      120

gaaccgcgac cactggagcc ttagcgggcg cagcagctgg aacgggagta ctgcgacgca      180

gcccggagtc ggccttgtag gggcgaaggt gcagggagat cgcggcgggc gcagtcttga      240

gcgccggagc gcgtccctgc ccttagcggg gcttgcccca gtcgcagggg cacatccagc      300

cgctgcggct gacagcagcc gcgcgcgcgg gagtctgcgg ggtcgcggca gccgcacctg      360

cgcgggcgac cagcgcaagg tccccgcccg gctgggcggg cagcaagggc cggggagagg      420

gtgcgggtgc aggcgggggc cccacagggc caccttcttg cccggcggct gccgctggaa      480

aatgtctcag gagaggccca cgttctaccg gcaggagctg aacaagacaa tctgggaggt      540

gcccgagcgt taccagaacc tgtctccagt gggctctggc gcctatggct ctgtgtgtgc      600

tgcttttgac acaaaaacgg ggttacgtgt ggcagtgaag aagctctcca gaccatttca      660

gtccatcatt catgcgaaaa gaacctacag agaactgcgg ttacttaaac atatgaaaca      720

tgaaaatgtg attggtctgt tggacgtttt tacacctgca aggtctctgg aggaattcaa      780

tgatgtgtat ctggtgaccc atctcatggg ggcagatctg aacaacattg tgaaatgtca      840

gaagcttaca gatgaccatg ttcagttcct tatctaccaa attctccgag gtctaaagta      900

tatacattca gctgacataa ttcacaggga cctaaaacct agtaatctag ctgtgaatga      960

agactgtgag ctgaagattc tggattttgg actggctcgg cacacagatg atgaaatgac     1020

aggctacgtg gccactaggt ggtacagggc tcctgagatc atgctgaact ggatgcatta     1080

caaccagaca gttgatattt ggtcagtggg atgcataatg gccgagctgt tgactggaag     1140

aacattgttt cctggtacag accatattga tcagttgaag ctcattttaa gactcgttgg     1200

aaccccaggg gctgagcttt tgaagaaaat ctcctcagag tctgcaagaa actatattca     1260

gtctttgact cagatgccga agatgaactt tgcgaatgta tttattggtg ccaatcccct     1320

gggtaagttg accatatatc ctcacctcat ggatattgaa ttggttatga tataaattgg     1380

ggatttgaag aagagtttct ccttttgacc aaataaagta ccattagttg a              1431


<210>  11
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe 
    130                 135                 140                 


Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro 
145                 150                 155                 160 


Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln 
                165                 170                 175     


Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly 
            180                 185                 190         


Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val 
        195                 200                 205             


Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg 
    210                 215                 220                 


Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr 
225                 230                 235                 240 


Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp 
                245                 250                 255     


Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr 
            260                 265                 270         


Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys 
        275                 280                 285             


Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp 
    290                 295                 300                 


Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser 
305                 310                 315                 320 


Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn 
                325                 330                 335     


Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys 
            340                 345                 350         


Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys 
        355                 360                 365             


Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe 
    370                 375                 380                 


Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu 
385                 390                 395                 400 


Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala 
                405                 410                 415     


Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly 
            420                 425                 430         


Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser 
        435                 440                 445             


Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu 
    450                 455                 460                 


Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser 
465                 470                 475                 480 


Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile 
                485                 490                 495     


Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu 
            500                 505                 510         


Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro 
        515                 520                 525             


Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro 
    530                 535                 540                 


Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly 
545                 550                 555                 560 


Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg 
                565                 570                 575     


Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val 
            580                 585                 590         


Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser 
        595                 600                 605             


Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His 
    610                 615                 620                 


Gln Ile Arg Gly Phe Leu Ser Arg Phe Asp Asn Val Leu Pro Val Ser 
625                 630                 635                 640 


Leu Ala Phe Asp Lys Cys Thr Ala Cys Ser Ser Lys Val Leu Asp Gln 
                645                 650                 655     


Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys Val Phe Asn Ser Ser 
            660                 665                 670         


His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr Leu Leu His Gln Glu 
        675                 680                 685             


Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp Asp Glu Thr Ile 
    690                 695                 700             


<210>  12
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


