                         SEQUENCE LISTING

<110>  Nanjing Leads Biolabs Co., Ltd
 
<120>  ANTIBODIES BINDING LAG-3 AND USES THEREOF

<130>  55534 00005

<150>  US62/531892
<151>  2017-07-13

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  1
gattacggca tgtct                                                        15


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Tyr Gly Met Ser 
1               5   


<210>  3
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcatcaact ggtctggcgg ctccacatac tatgctgaca gcgtgaaggg c                51


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  5
ggaggatat                                                               9


<210>  6
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Gly Tyr 
1               


<210>  7
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  7
cgggcaagtc agagcattag cagctattta aat                                    33


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  9
gctgcatcca gtttgcaagg t                                                 21


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Ser Ser Leu Gln Gly 
1               5           


<210>  11
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  11
caacagagtt acagtacccc gtacact                                           27


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  13
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  13
caggtgcagc tgcaggagtc tggaggagga gtggtgagac caggaggatc cctgcgcctg       60

agctgcgccg cttctggctt cacctttgac                                        90


<210>  14
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  15
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  15
tgggtgaggc aggctcctgg caagggactg gagtgggtgt cc                          42


<210>  16
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  16

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  17
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  17
aggagcacca tctctcggga taactccaag aatacactgt acctgcagat gaatagcctg       60

agagccgagg acaccgccgt gtactattgt gctaca                                 96


<210>  18
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  19
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  19
tggggacagg gcaccctggt gacagtgtcc agc                                    33


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  21
gacatccggt tgacccagtc cccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

attacttgc                                                               69


<210>  22
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  23
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  23
tggtatcagc agaaaccagg gaaagcccct aagctcctga tctat                       45


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  25
ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc       60

agtctgcaac ctgaagattc tgcaacttac tactgt                                 96


<210>  26
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  27
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  27
tttggccagg ggaccaagct caccgtccta ggt                                    33


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  29
<211>  1965
<212>  DNA
<213>  Homo sapiens

<400>  29
caggtgcagc tgcaggagtc tggaggagga gtggtgagac caggaggatc cctgcgcctg       60

agctgcgccg cttctggctt cacctttgac gattacggca tgtcttgggt gaggcaggct      120

cctggcaagg gactggagtg ggtgtccggc atcaactggt ctggcggctc cacatactat      180

gctgacagcg tgaagggcag gagcaccatc tctcgggata actccaagaa tacactgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtgt actattgtgc tacaggagga      300

tattggggac agggcaccct ggtgacagtg tccagcgcta gcacaaaggg accttccgtg      360

ttcccactgg ccccctgctc cagaagcaca tctgagtcca ccgccgctct gggctgtctg      420

gtgaaggact acttccctga gccagtgacc gtgtcctgga acagcggcgc cctgacatcc      480

ggagtgcaca cctttcccgc cgtgctccag tccagcggac tgtacagcct gtcttccgtg      540

gtgacagtgc ccagctcttc cctgggcacc aagacatata cctgcaacgt ggaccataag      600

cctagcaata ccaaggtgga taagagggtg gagtctaagt acggaccacc ttgcccacca      660

tgtccagctc ctgagtttct gggaggacca tccgtgttcc tgtttcctcc aaagcctaag      720

gacaccctga tgatctctcg gacacctgag gtgacctgcg tggtggtgga cgtgtcccag      780

gaggaccccg aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgctaag      840

accaagccaa gagaggagca gtttaatagc acataccgcg tggtgtctgt gctgaccgtg      900

ctgcatcagg attggctgaa cggcaaggag tataagtgca aggtgagcaa taagggcctg      960

cccagctcta tcgagaagac aatctctaag gctaagggac agcctcgcga gccacaggtg     1020

tacaccctgc ccccttccca ggaggagatg acaaagaacc aggtgagcct gacctgtctg     1080

gtgaagggct tctatccatc tgacatcgct gtggagtggg agtccaacgg ccagcccgag     1140

aacaattaca agaccacacc acccgtgctg gactctgatg gctccttctt tctgtattcc     1200

aggctgacag tggataagag ccggtggcag gagggcaacg tgtttagctg ctctgtgatg     1260

cacgaggctc tgcacaatca ttatacccag aagtccctga gcctgtctct gggcaaggac     1320

atccggttga cccagtcccc atcctccctg tctgcatctg taggagacag agtcaccatt     1380

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg     1440

aaagccccta agctcctgat ctatgctgca tccagtttgc aaggtggggt cccatcaagg     1500

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa     1560

gattctgcaa cttactactg tcaacagagt tacagtaccc cgtacacttt tggccagggg     1620

accaagctca ccgtcctagg tcgtacggtg gctgcaccat ctgtcttcat cttcccgcca     1680

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctac     1740

cccagagaag ccaaagtgca gtggaaggtg gacaacgccc tgcagagcgg aaacagccag     1800

gaaagcgtga cagagcagga ttccaaggat tccacataca gcctgagcag cacactgaca     1860

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac acaccaggga     1920

ctgtcctccc ctgtgacaaa gagcttcaac agaggagaat gctga                     1965


<210>  30
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Leu Gly Lys Asp Ile Arg Leu Thr Gln Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    450                 455                 460                 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
465                 470                 475                 480 


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Gly Gly 
                485                 490                 495     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            500                 505                 510         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln 
        515                 520                 525             


Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Thr 
    530                 535                 540                 


Val Leu Gly Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
545                 550                 555                 560 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                565                 570                 575     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            580                 585                 590         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        595                 600                 605             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    610                 615                 620                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
625                 630                 635                 640 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                645                 650                 


<210>  31
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  31
caggtgcagc tgcaggagtc tggaggagga gtggtgagac caggaggatc cctgcgcctg       60

agctgcgccg cttctggctt cacctttgac gattacggca tgtcttgggt gaggcaggct      120

cctggcaagg gactggagtg ggtgtccggc atcaactggt ctggcggctc cacatactat      180

gctgacagcg tgaagggcag gagcaccatc tctcgggata actccaagaa tacactgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtgt actattgtgc tacaggagga      300

tattggggac agggcaccct ggtgacagtg tccagc                                336


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  33
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  33
gacatccggt tgacccagtc cccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

attacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaggtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattctg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag      300

gggaccaagc tcaccgtcct aggt                                             324


<210>  34
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  35
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  35
caggtgcagc tgcaggagtc tggaggagga gtggtgagac caggaggatc cctgcgcctg       60

agctgcgccg cttctggctt cacctttgac gattacggca tgtcttgggt gaggcaggct      120

cctggcaagg gactggagtg ggtgtccggc atcaactggt ctggcggctc cacatactat      180

gctgacagcg tgaagggcag gagcaccatc tctcgggata actccaagaa tacactgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtgt actattgtgc tacaggagga      300

tattggggac agggcaccct ggtgacagtg tccagcgcta gcacaaaggg accttccgtg      360

ttcccactgg ccccctgctc cagaagcaca tctgagtcca ccgccgctct gggctgtctg      420

gtgaaggact acttccctga gccagtgacc gtgtcctgga acagcggcgc cctgacatcc      480

ggagtgcaca cctttcccgc cgtgctccag tccagcggac tgtacagcct gtcttccgtg      540

gtgacagtgc ccagctcttc cctgggcacc aagacatata cctgcaacgt ggaccataag      600

cctagcaata ccaaggtgga taagagggtg gagtctaagt acggaccacc ttgcccacca      660

tgtccagctc ctgagtttct gggaggacca tccgtgttcc tgtttcctcc aaagcctaag      720

gacaccctga tgatctctcg gacacctgag gtgacctgcg tggtggtgga cgtgtcccag      780

gaggaccccg aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgctaag      840

accaagccaa gagaggagca gtttaatagc acataccgcg tggtgtctgt gctgaccgtg      900

ctgcatcagg attggctgaa cggcaaggag tataagtgca aggtgagcaa taagggcctg      960

cccagctcta tcgagaagac aatctctaag gctaagggac agcctcgcga gccacaggtg     1020

tacaccctgc ccccttccca ggaggagatg acaaagaacc aggtgagcct gacctgtctg     1080

gtgaagggct tctatccatc tgacatcgct gtggagtggg agtccaacgg ccagcccgag     1140

aacaattaca agaccacacc acccgtgctg gactctgatg gctccttctt tctgtattcc     1200

aggctgacag tggataagag ccggtggcag gagggcaacg tgtttagctg ctctgtgatg     1260

cacgaggctc tgcacaatca ttatacccag aagtccctga gcctgtctct gggcaagtga     1320


<210>  36
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Leu Gly Lys 
        435                 


<210>  37
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  37
gacatccggt tgacccagtc cccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

attacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaggtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattctg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag      300

gggaccaagc tcaccgtcct aggtcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

taccccagag aagccaaagt gcagtggaag gtggacaacg ccctgcagag cggaaacagc      480

caggaaagcg tgacagagca ggattccaag gattccacat acagcctgag cagcacactg      540

acactgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacacaccag      600

ggactgtcct cccctgtgac aaagagcttc aacagaggag aatgctga                   648


<210>  38
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  39
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Thr Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  40
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  40

Ser Gly Gly Ser Thr Ile Thr Ser Tyr Asn Val Tyr Tyr Thr Lys Leu 
1               5                   10                  15      


Ser Ser Ser Gly Thr 
            20      


<210>  41
<211>  1989
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

ccctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagggg      300

agctactatt tggagggtat tgactactgg ggccagggaa ccctggtcac cgtctcttca      360

gctagcacaa agggaccttc cgtgttccca ctggccccct gctccagaag cacatctgag      420

tccaccgccg ctctgggctg tctggtgaag gactacttcc ctgagccagt gaccgtgtcc      480

tggaacagcg gcgccctgac atccggagtg cacacctttc ccgccgtgct ccagtccagc      540

ggactgtaca gcctgtcttc cgtggtgaca gtgcccagct cttccctggg caccaagaca      600

tatacctgca acgtggacca taagcctagc aataccaagg tggataagag ggtggagtct      660

aagtacggac caccttgccc accatgtcca gctcctgagt ttctgggagg accatccgtg      720

ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacacc tgaggtgacc      780

tgcgtggtgg tggacgtgtc ccaggaggac cccgaggtgc agttcaactg gtacgtggat      840

ggcgtggagg tgcacaatgc taagaccaag ccaagagagg agcagtttaa tagcacatac      900

cgcgtggtgt ctgtgctgac cgtgctgcat caggattggc tgaacggcaa ggagtataag      960

tgcaaggtga gcaataaggg cctgcccagc tctatcgaga agacaatctc taaggctaag     1020

ggacagcctc gcgagccaca ggtgtacacc ctgccccctt cccaggagga gatgacaaag     1080

aaccaggtga gcctgacctg tctggtgaag ggcttctatc catctgacat cgctgtggag     1140

tgggagtcca acggccagcc cgagaacaat tacaagacca caccacccgt gctggactct     1200

gatggctcct tctttctgta ttccaggctg acagtggata agagccggtg gcaggagggc     1260

aacgtgttta gctgctctgt gatgcacgag gctctgcaca atcattatac ccagaagtcc     1320

ctgagcctgt ctctgggcaa gcagtctgtg ctgacgcagc caccctcggt gtctgaagcc     1380

cccaggcaga gggtcaccat ctcctgttct ggaagcagtt ccaacatcgg agataatgct     1440

gtaaactggt accagcagct cccaggaaag gctcccacac tcctcatcta ttatgatgat     1500

ctgctgccct caggggtccc tgaccgattc tctggctcca agtctggcac ctcagcctcc     1560

ctggccatca gcgggctcca gtctgaggat gaggctgaat attactgcgc agcatgggat     1620

gacagcctga aaggttatgt cttcggaacg gggaccaagc tcaccgtcct aggtcagccc     1680

aaggccgccc cctccgtgac actgttccct ccctcctccg aggagctgca ggccaacaag     1740

gccaccctgg tgtgcctgat ctccgacttc taccctggcg ccgtgaccgt ggcttggaag     1800

gctgactcct cccctgtgaa ggccggcgtg gagacaacca ccccctccaa gcagtccaac     1860

aacaagtacg ccgcctcctc ctacctgtcc ctgacccctg agcagtggaa gagccacagg     1920

tcctactcct gccaggtgac ccacgagggc tccaccgtgg agaagaccgt ggcccctacc     1980

gagtgctcc                                                             1989


<210>  42
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Tyr Tyr Leu Glu Gly Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gln 
        435                 440                 445             


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg 
    450                 455                 460                 


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Ala 
465                 470                 475                 480 


Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Thr Leu Leu Ile 
                485                 490                 495     


Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
            500                 505                 510         


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Lys 
    530                 535                 540                 


Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
545                 550                 555                 560 


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
                565                 570                 575     


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
            580                 585                 590         


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
        595                 600                 605             


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
    610                 615                 620                 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
625                 630                 635                 640 


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
                645                 650                 655     


Val Ala Pro Thr Glu Cys Ser 
            660             


<210>  43
<211>  1953
<212>  DNA
<213>  Homo sapiens

<400>  43
caggtgcagc tgcaggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attaattgga gcggtggtag cacatactac      180

gcagactccg tgaagggccg atccaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gacaggaggc      300

tactggggcc agggaaccct ggtcactgtc tcttcagcta gcacaaaggg accttccgtg      360

ttcccactgg ccccctgctc cagaagcaca tctgagtcca ccgccgctct gggctgtctg      420

gtgaaggact acttccctga gccagtgacc gtgtcctgga acagcggcgc cctgacatcc      480

ggagtgcaca cctttcccgc cgtgctccag tccagcggac tgtacagcct gtcttccgtg      540

gtgacagtgc ccagctcttc cctgggcacc aagacatata cctgcaacgt ggaccataag      600

cctagcaata ccaaggtgga taagagggtg gagtctaagt acggaccacc ttgcccacca      660

tgtccagctc ctgagtttct gggaggacca tccgtgttcc tgtttcctcc aaagcctaag      720

gacaccctga tgatctctcg gacacctgag gtgacctgcg tggtggtgga cgtgtcccag      780

gaggaccccg aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgctaag      840

accaagccaa gagaggagca gtttaatagc acataccgcg tggtgtctgt gctgaccgtg      900

ctgcatcagg attggctgaa cggcaaggag tataagtgca aggtgagcaa taagggcctg      960

cccagctcta tcgagaagac aatctctaag gctaagggac agcctcgcga gccacaggtg     1020

tacaccctgc ccccttccca ggaggagatg acaaagaacc aggtgagcct gacctgtctg     1080

gtgaagggct tctatccatc tgacatcgct gtggagtggg agtccaacgg ccagcccgag     1140

aacaattaca agaccacacc acccgtgctg gactctgatg gctccttctt tctgtattcc     1200

aggctgacag tggataagag ccggtggcag gagggcaacg tgtttagctg ctctgtgatg     1260

cacgaggctc tgcacaatca ttatacccag aagtccctga gcctgtctct gggcaagtcc     1320

tatgagctga ctcagccacc ctcagtgtcc gtgtccccag gacagacagc cagcatcacc     1380

tgctctggag ataaattggg ggataaatat acttcctggt atcaacagaa gccaggccag     1440

tcccctctac tggtcatcta tcaatctacc aagcggccct caggaatccc tgagcgattc     1500

tctggctcca actctgggga cacagccact ctgaccatca gcgggaccca gcctatggat     1560

gaggctgact attactgtca ggcgtgggac agcagtactg cggtgttcgg cggagggacc     1620

aagctgaccg tcctaggtca gcccaaggcc gccccctccg tgacactgtt ccctccctcc     1680

tccgaggagc tgcaggccaa caaggccacc ctggtgtgcc tgatctccga cttctaccct     1740

ggcgccgtga ccgtggcttg gaaggctgac tcctcccctg tgaaggccgg cgtggagaca     1800

accaccccct ccaagcagtc caacaacaag tacgccgcct cctcctacct gtccctgacc     1860

cctgagcagt ggaagagcca caggtcctac tcctgccagg tgacccacga gggctccacc     1920

gtggagaaga ccgtggcccc taccgagtgc tcc                                  1953


<210>  44
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Leu Gly Lys Ser Tyr Glu Leu Thr Gln Pro Pro Ser 
        435                 440                 445             


Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp 
    450                 455                 460                 


Lys Leu Gly Asp Lys Tyr Thr Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
465                 470                 475                 480 


Ser Pro Leu Leu Val Ile Tyr Gln Ser Thr Lys Arg Pro Ser Gly Ile 
                485                 490                 495     


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Thr Ala Thr Leu Thr 
            500                 505                 510         


Ile Ser Gly Thr Gln Pro Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala 
        515                 520                 525             


Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    530                 535                 540                 


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
545                 550                 555                 560 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
                565                 570                 575     


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
            580                 585                 590         


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
        595                 600                 605             


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
    610                 615                 620                 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
625                 630                 635                 640 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                645                 650     


<210>  45
<211>  1965
<212>  DNA
<213>  Homo sapiens

<400>  45
caggtgcagc tgcaggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attaattgga gcggtggtag cacatactac      180

gcagactccg tgaagggccg atccaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gacaggaggc      300

tactggggcc agggaaccct ggtcactgtc tcttcagcta gcacaaaggg accttccgtg      360

ttcccactgg ccccctgctc cagaagcaca tctgagtcca ccgccgctct gggctgtctg      420

gtgaaggact acttccctga gccagtgacc gtgtcctgga acagcggcgc cctgacatcc      480

ggagtgcaca cctttcccgc cgtgctccag tccagcggac tgtacagcct gtcttccgtg      540

gtgacagtgc ccagctcttc cctgggcacc aagacatata cctgcaacgt ggaccataag      600

cctagcaata ccaaggtgga taagagggtg gagtctaagt acggaccacc ttgcccacca      660

tgtccagctc ctgagtttct gggaggacca tccgtgttcc tgtttcctcc aaagcctaag      720

gacaccctga tgatctctcg gacacctgag gtgacctgcg tggtggtgga cgtgtcccag      780

gaggaccccg aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgctaag      840

accaagccaa gagaggagca gtttaatagc acataccgcg tggtgtctgt gctgaccgtg      900

ctgcatcagg attggctgaa cggcaaggag tataagtgca aggtgagcaa taagggcctg      960

cccagctcta tcgagaagac aatctctaag gctaagggac agcctcgcga gccacaggtg     1020

tacaccctgc ccccttccca ggaggagatg acaaagaacc aggtgagcct gacctgtctg     1080

gtgaagggct tctatccatc tgacatcgct gtggagtggg agtccaacgg ccagcccgag     1140

aacaattaca agaccacacc acccgtgctg gactctgatg gctccttctt tctgtattcc     1200

aggctgacag tggataagag ccggtggcag gagggcaacg tgtttagctg ctctgtgatg     1260

cacgaggctc tgcacaatca ttatacccag aagtccctga gcctgtctct gggcaagcag     1320

tctgtgctga ctcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc     1380

tgcactggga gcagctccaa catcggggca ggttatgatg tacactggta ccagcagctt     1440

ccaggaacag cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct     1500

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag     1560

gctgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tgtggtattc     1620

ggcggaggga ccaagctcac cgtcctaggt cagcccaagg ccgccccctc cgtgacactg     1680

ttccctccct cctccgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatctcc     1740

gacttctacc ctggcgccgt gaccgtggct tggaaggctg actcctcccc tgtgaaggcc     1800

ggcgtggaga caaccacccc ctccaagcag tccaacaaca agtacgccgc ctcctcctac     1860

ctgtccctga cccctgagca gtggaagagc cacaggtcct actcctgcca ggtgacccac     1920

gagggctcca ccgtggagaa gaccgtggcc cctaccgagt gctcc                     1965


<210>  46
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Leu Gly Lys Gln Ser Val Leu Thr Gln Pro Pro Ser 
        435                 440                 445             


Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser 
    450                 455                 460                 


Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu 
465                 470                 475                 480 


Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro 
                485                 490                 495     


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala 
            500                 505                 510         


Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
        515                 520                 525             


Cys Gln Ser Tyr Asp Ser Ser Leu Ser Val Val Phe Gly Gly Gly Thr 
    530                 535                 540                 


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
545                 550                 555                 560 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
                565                 570                 575     


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
            580                 585                 590         


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
        595                 600                 605             


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
    610                 615                 620                 


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
625                 630                 635                 640 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                645                 650                 655 


<210>  47
<211>  1992
<212>  DNA
<213>  Homo sapiens

<400>  47
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaatttaga      300

agcagcagct ggtacgacta ctttgactcc tggggccagg gaaccctggt caccgtctct      360

tcagctagca caaagggacc ttccgtgttc ccactggccc cctgctccag aagcacatct      420

gagtccaccg ccgctctggg ctgtctggtg aaggactact tccctgagcc agtgaccgtg      480

tcctggaaca gcggcgccct gacatccgga gtgcacacct ttcccgccgt gctccagtcc      540

agcggactgt acagcctgtc ttccgtggtg acagtgccca gctcttccct gggcaccaag      600

acatatacct gcaacgtgga ccataagcct agcaatacca aggtggataa gagggtggag      660

tctaagtacg gaccaccttg cccaccatgt ccagctcctg agtttctggg aggaccatcc      720

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tctctcggac acctgaggtg      780

acctgcgtgg tggtggacgt gtcccaggag gaccccgagg tgcagttcaa ctggtacgtg      840

gatggcgtgg aggtgcacaa tgctaagacc aagccaagag aggagcagtt taatagcaca      900

taccgcgtgg tgtctgtgct gaccgtgctg catcaggatt ggctgaacgg caaggagtat      960

aagtgcaagg tgagcaataa gggcctgccc agctctatcg agaagacaat ctctaaggct     1020

aagggacagc ctcgcgagcc acaggtgtac accctgcccc cttcccagga ggagatgaca     1080

aagaaccagg tgagcctgac ctgtctggtg aagggcttct atccatctga catcgctgtg     1140

gagtgggagt ccaacggcca gcccgagaac aattacaaga ccacaccacc cgtgctggac     1200

tctgatggct ccttctttct gtattccagg ctgacagtgg ataagagccg gtggcaggag     1260

ggcaacgtgt ttagctgctc tgtgatgcac gaggctctgc acaatcatta tacccagaag     1320

tccctgagcc tgtctctggg caagcagtct gtgttgacgc agccaccctc agcgtctggg     1380

acccccgggc agagggtcac catctcttgt tctggaagca gctccaacat cggaagtaat     1440

actgtaaact ggtaccagca gctcccagga acggccccca aactcctcat ctatagtaat     1500

aatcagcggc cctcaggggt ccctgaccga ttctctggct ccaagtctgg cacctcagcc     1560

tccctggcca tcagtgggct ccagtctgag gatgaggctg attattactg tgcagcatgg     1620

gatgacagcc tgaatggttg ggtgttcggc ggagggacca agctcaccgt cctaggtcag     1680

cccaaggccg ccccctccgt gacactgttc cctccctcct ccgaggagct gcaggccaac     1740

aaggccaccc tggtgtgcct gatctccgac ttctaccctg gcgccgtgac cgtggcttgg     1800

aaggctgact cctcccctgt gaaggccggc gtggagacaa ccaccccctc caagcagtcc     1860

aacaacaagt acgccgcctc ctcctacctg tccctgaccc ctgagcagtg gaagagccac     1920

aggtcctact cctgccaggt gacccacgag ggctccaccg tggagaagac cgtggcccct     1980

accgagtgct cc                                                         1992


<210>  48
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Arg Ser Ser Ser Trp Tyr Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
    450                 455                 460                 


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
465                 470                 475                 480 


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
                485                 490                 495     


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
            500                 505                 510         


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
        515                 520                 525             


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
    530                 535                 540                 


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
545                 550                 555                 560 


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
                565                 570                 575     


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            580                 585                 590         


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        595                 600                 605             


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    610                 615                 620                 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
625                 630                 635                 640 


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                645                 650                 655     


Thr Val Ala Pro Thr Glu Cys Ser 
            660                 


<210>  49
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  50
<211>  450
<212>  PRT
<213>  Macaca mulatta

<400>  50

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Pro Gln Pro Gly Ala Glu Ile Ser Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Pro Ala Pro Gly His Pro Pro 
65                  70                  75                  80  


Ala Pro Gly His Arg Pro Ala Ala Pro Tyr Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Thr Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Val Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Thr Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Ser Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Gln Gly Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro His Val Gly Pro Met Asp Ser Gly Leu Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Ala Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Glu Leu Pro Cys Arg Leu Pro Pro Ala Val 
        275                 280                 285             


Gly Thr Gln Ser Phe Leu Thr Ala Lys Trp Ala Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Ala Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Ile Cys His Ile Arg 
                325                 330                 335     


Leu Gln Gly Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Ala Ser Gly Gln Glu His Phe Val Trp Ser Pro 
    370                 375                 380                 


Leu Asn Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu His Gln 
                405                 410                 415     


Gly Glu Thr Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Arg Ala Gly 
        435                 440                 445             


His Leu 
    450 
