                         б

<110>  Ĵײ̩ҽҩɷ޹˾
 
<120>  ˫鵰

<130>  IEC170086PCT

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB01 VL

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  2
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  AB01 LCDR1

<400>  2

Gln Gly Ile Arg Asn Tyr 
1               5       


<210>  3
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  AB01 LCDR2

<400>  3

Ala Ala Ser 
1           


<210>  4
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  AB01 LCDR3

<400>  4

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  5
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  AB01 VH

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  AB01 HCDR1

<400>  6

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  7
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  AB01 HCDR2

<400>  7

Ala Ile Thr Trp Asn Ser Gly His Ile Asp 
1               5                   10  


<210>  8
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  AB01 HCDR3

<400>  8

Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10                  


<210>  9
<211>  108
<212>  PRT
<213>  ˹

<220>
<223>  AB02 VL

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  10
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  AB02 LCDR1

<400>  10

Gln Ser Val Tyr Ser Tyr 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  AB02 LCDR2

<400>  11

Asp Ala Ser 
1           


<210>  12
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  AB02 LCDR2

<400>  12

Gln Gln Arg Ser Asn Trp Pro Pro Phe Thr 
1               5                   10  


<210>  13
<211>  126
<212>  PRT
<213>  ˹

<220>
<223>  AB02 VH

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  14
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  AB02 HCDR1

<400>  14

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  AB02 HCDR2

<400>  15

Met Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  16
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  AB02 HCDR2

<400>  16

Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  17
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB03 VL

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  AB03 LCDR1

<400>  18

Gln Asp Ile Ser Ser Tyr 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  AB03 LCDR2

<400>  19

Tyr Thr Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  AB03 LCDR3

<400>  20

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  21
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  AB03 VH

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  AB03 HCDR1

<400>  22

Gly Tyr Ser Ile Thr Ser Asp His Ala 
1               5                   


<210>  23
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  AB03 HCDR2

<400>  23

Ile Ser Tyr Ser Gly Ile Thr 
1               5           


<210>  24
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  AB03 HCDR3

<400>  24

Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr 
1               5                   10          


<210>  25
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB04 VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  AB04 LCDR1

<400>  26

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  27
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  AB04 LCDR2

<400>  27

Gly Ala Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  AB04 LCDR3

<400>  28

Gln Gln Ala Asn Ser Phe Pro Tyr Thr 
1               5                   


<210>  29
<211>  116
<212>  PRT
<213>  ˹

<220>
<223>  AB04 VH

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  AB04 HCDR1

<400>  30

Arg Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  AB04 HCDR2

<400>  31

Ile Ser Trp Asn Ser Gly Arg Ile 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  AB04 HCDR3

<400>  32

Ala Lys Gly Arg Asp Ser Phe Asp Ile 
1               5                   


<210>  33
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  Ľͷ

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  34
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  Ľͷ

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  Ľͷ

<400>  35

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  36
<211>  712
<212>  PRT
<213>  ˹

<220>
<223>  TNAһ

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
            260                 265                 270         


Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser Trp Val Arg Gln Pro 
    290                 295                 300                 


Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ile 
305                 310                 315                 320 


Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Arg Asp 
                325                 330                 335     


Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
            340                 345                 350         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Leu Ala Arg Thr Thr Ala 
        355                 360                 365             


Met Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        435                 440                 445             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


<210>  37
<211>  2139
<212>  DNA
<213>  ˹

<220>
<223>  TNAһ

<400>  37
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggctgc      300

ggcacaaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tgaagtccag ctggtcgaaa gcgggggggg gctggtgcag      420

cctggcaggt ctctgcggct gtcctgcgcc gctagcggct tcacctttga cgattacgcc      480

atgcactggg tgagacaggc tccaggcaag tgcctggagt gggtgagcgc catcacctgg      540

aactctggcc atatcgacta cgctgatagc gtggagggca gattcacaat ctctagggac      600

aacgccaaga actccctgta tctgcaaatg aatagcctga gggccgagga taccgccgtg      660

tactattgcg ccaaggtgtc ttacctgagc accgcttcca gcctggacta ttggggccag      720

ggcaccctgg tgacagtgtc ttccggagga ggaggatccg gaggaggagg aagcggtggc      780

ggcggctctc aggtgcagct gcaggagagc ggacctggac tggtgagacc aagccagacc      840

ctgtctctga cctgcacagt gtctggctac tccatcacaa gcgatcacgc ttggtcttgg      900

gtgagacagc cacctggaag gggactggag tggatcggct acatcagcta ttctggcatc      960

accacatata acccctctct gaagtccagg gtgaccatgc tgcgggacac atccaagaat     1020

cagttcagcc tgaggctgtc cagcgtgacc gctgctgata cagccgtgta ctattgtgcc     1080

aggtccctgg ctcggaccac agccatggac tactggggac agggatccct ggtgaccgtg     1140

tcttccgcct ctacaaaggg cccctccgtg tttccactgg ctccctcctc taagagcacc     1200

tctggcggca cagccgctct gggctgtctg gtgaaggatt acttcccaga gcccgtgaca     1260

gtgagctgga actctggcgc cctgacctct ggagtgcaca catttccagc tgtgctgcag     1320

tccagcggcc tgtactccct gtcttccgtg gtgaccgtgc ccagctcttc cctgggcacc     1380

cagacatata tctgcaacgt gaaccacaag ccatccaata caaaggtgga caagaaggtg     1440

gagcccaagt cctgtgataa gacccataca tgcccccctt gtcctgctcc agagctgctg     1500

ggaggacctt ccgtgttcct gtttccaccc aaacctaagg acaccctgat gatcagcagg     1560

acccccgagg tgacatgcgt ggtggtggac gtgtctcacg aggatcccga ggtgaagttc     1620

aactggtatg tcgatggcgt ggaggtgcat aatgctaaga ccaagcctcg ggaggagcag     1680

tacaactcca cctatagagt ggtgagcgtg ctgacagtgc tgcatcagga ctggctgaac     1740

ggcaaggagt ataagtgcaa ggtgtccaat aaggccctgc ccgctcccat cgagaagacc     1800

atcagcaagg ccaagggcca gccaagggag ccacaggtgt acacactgcc tccatcccgg     1860

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctatcctagc     1920

gatatcgctg tggagtggga gtccaatggc cagccagaga acaattacaa gaccacaccc     1980

cctgtgctgg actccgatgg cagcttcttt ctgtattcta agctgaccgt ggataagtcc     2040

cggtggcagc agggcaacgt gttctcctgt agcgtgatgc acgaagccct gcataatcac     2100

tatactcaga aaagtctgtc actgtcacct ggtaaatga                            2139


<210>  38
<211>  706
<212>  PRT
<213>  ˹

<220>
<223>  TCAһ

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    450                 455                 460                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
465                 470                 475                 480 


Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln 
                485                 490                 495     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu 
            500                 505                 510         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        515                 520                 525             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr 
    530                 535                 540                 


Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Cys Gly Thr 
545                 550                 555                 560 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            580                 585                 590         


Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
        595                 600                 605             


Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln 
    610                 615                 620                 


Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser 
625                 630                 635                 640 


Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser 
                645                 650                 655     


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            660                 665                 670         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser 
        675                 680                 685             


Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210>  39
<211>  2121
<212>  DNA
<213>  ˹

<220>
<223>  TCAһ

<400>  39
caggtgcagc tgcaggagag cggacctgga ctggtgagac caagccagac cctgtctctg       60

acctgcacag tgtctggcta ctccatcaca agcgatcacg cttggtcttg ggtgagacag      120

ccacctggaa ggggactgga gtggatcggc tacatcagct attctggcat caccacatat      180

aacccctctc tgaagtccag ggtgaccatg ctgcgggaca catccaagaa tcagttcagc      240

ctgaggctgt ccagcgtgac cgctgctgat acagccgtgt actattgtgc caggtccctg      300

gctcggacca cagccatgga ctactgggga cagggatccc tggtgaccgt gtcttccgcc      360

tctacaaagg gcccctccgt gtttccactg gctccctcct ctaagagcac ctctggcggc      420

acagccgctc tgggctgtct ggtgaaggat tacttcccag agcccgtgac agtgagctgg      480

aactctggcg ccctgacctc tggagtgcac acatttccag ctgtgctgca gtccagcggc      540

ctgtactccc tgtcttccgt ggtgaccgtg cccagctctt ccctgggcac ccagacatat      600

atctgcaacg tgaaccacaa gccatccaat acaaaggtgg acaagaaggt ggagcccaag      660

tcctgtgata agacccatac atgcccccct tgtcctgctc cagagctgct gggaggacct      720

tccgtgttcc tgtttccacc caaacctaag gacaccctga tgatcagcag gacccccgag      780

gtgacatgcg tggtggtgga cgtgtctcac gaggatcccg aggtgaagtt caactggtat      840

gtcgatggcg tggaggtgca taatgctaag accaagcctc gggaggagca gtacaactcc      900

acctatagag tggtgagcgt gctgacagtg ctgcatcagg actggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg cccgctccca tcgagaagac catcagcaag     1020

gccaagggcc agccaaggga gccacaggtg tacacactgc ctccatcccg ggacgagctg     1080

accaagaacc aggtgagcct gacatgtctg gtgaagggct tctatcctag cgatatcgct     1140

gtggagtggg agtccaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1200

gactccgatg gcagcttctt tctgtattct aagctgaccg tggataagtc ccggtggcag     1260

cagggcaacg tgttctcctg tagcgtgatg cacgaagccc tgcataatca ctatactcag     1320

aaaagtctgt cactgtcacc tggtggagga ggaggatccg gaggaggagg aagcgatatt     1380

cagatgactc agtccccttc tagtctgtcc gcctctgtgg gcgacagagt gaccatcaca     1440

tgcagggcca gccagggcat ccggaactac ctggcttggt atcagcagaa gccaggcaag     1500

gcccccaagc tgctgatcta cgccgcttcc accctgcaaa gcggagtgcc atctcggttc     1560

tccggcagcg gctctggcac agactttacc ctgacaatct ccagcctgca gcctgaggat     1620

gtggctacct actattgcca gaggtacaat cgggccccat ataccttcgg ctgcggcaca     1680

aaggtggaga tcaagggcgg cggcggctct ggcggcggcg gctctggtgg cggcggcagt     1740

ggcggcggcg gctctgaagt ccagctggtc gaaagcgggg gggggctggt gcagcctggc     1800

aggtctctgc ggctgtcctg cgccgctagc ggcttcacct ttgacgatta cgccatgcac     1860

tgggtgagac aggctccagg caagtgcctg gagtgggtga gcgccatcac ctggaactct     1920

ggccatatcg actacgctga tagcgtggag ggcagattca caatctctag ggacaacgcc     1980

aagaactccc tgtatctgca aatgaatagc ctgagggccg aggataccgc cgtgtactat     2040

tgcgccaagg tgtcttacct gagcaccgct tccagcctgg actattgggg ccagggcacc     2100

ctggtgacag tgtcttcctg a                                               2121


<210>  40
<211>  248
<212>  PRT
<213>  ˹

<220>
<223>  TNATCAscFv

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  41
<211>  744
<212>  DNA
<213>  ˹

<220>
<223>  TNATCAscFvı

<400>  41
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggctgc      300

ggcacaaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tgaagtccag ctggtcgaaa gcgggggggg gctggtgcag      420

cctggcaggt ctctgcggct gtcctgcgcc gctagcggct tcacctttga cgattacgcc      480

atgcactggg tgagacaggc tccaggcaag tgcctggagt gggtgagcgc catcacctgg      540

aactctggcc atatcgacta cgctgatagc gtggagggca gattcacaat ctctagggac      600

aacgccaaga actccctgta tctgcaaatg aatagcctga gggccgagga taccgccgtg      660

tactattgcg ccaaggtgtc ttacctgagc accgcttcca gcctggacta ttggggccag      720

ggcaccctgg tgacagtgtc ttcc                                             744


<210>  42
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  TNATCAڶ

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  645
<212>  DNA
<213>  ˹

<220>
<223>  TNATCAڶı

<400>  43
gacatccaga tgacccagtc tccaagctct ctgtccgcta gcgtgggcga cagagtgacc       60

atcacatgcc gcgcctccca ggacatctcc agctacctga actggtatca gcagaagcca      120

ggcaaggctc ccaagctgct gatctactat acctccaggc tgcatagcgg agtgccatct      180

cggttctctg gatccggaag cggaaccgac ttcaccttta caatctcttc cctgcagccc      240

gaggacatcg ccacctacta ttgtcagcag ggcaataccc tgccttatac atttggccag      300

ggcaccaagg tggagatcaa gagaacagtg gccgctccct ccgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ctaaggtgca gtggaaggtg gataacgccc tgcagtccgg caatagccag      480

gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca      540

ctgtctaagg ctgattacga gaagcacaag gtgtatgcct gtgaagtcac tcatcagggt      600

ctgtccagcc cagtcactaa gtcattcaac cgtggcgaat gctga                      645


<210>  44
<211>  477
<212>  PRT
<213>  ˹

<220>
<223>  TLNAһ

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        275                 280                 285             


Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    370                 375                 380                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
385                 390                 395                 400 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                405                 410                 415     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            420                 425                 430         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        435                 440                 445             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    450                 455                 460                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475         


<210>  45
<211>  1434
<212>  DNA
<213>  ˹

<220>
<223>  TLNAһ

<400>  45
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggctgc      300

ggcacaaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tgaagtccag ctggtcgaaa gcgggggggg gctggtgcag      420

cctggcaggt ctctgcggct gtcctgcgcc gctagcggct tcacctttga cgattacgcc      480

atgcactggg tgagacaggc tccaggcaag tgcctggagt gggtgagcgc catcacctgg      540

aactctggcc atatcgacta cgctgatagc gtggagggca gattcacaat ctctagggac      600

aacgccaaga actccctgta tctgcaaatg aatagcctga gggccgagga taccgccgtg      660

tactattgcg ccaaggtgtc ttacctgagc accgcttcca gcctggacta ttggggccag      720

ggcaccctgg tgacagtgtc ttccggagga ggaggatccg gaggaggagg aagcggtggc      780

ggcggctctg acatccagat gacccagtct ccaagctctc tgtccgctag cgtgggcgac      840

agagtgacca tcacatgccg cgcctcccag gacatctcca gctacctgaa ctggtatcag      900

cagaagccag gcaaggctcc caagctgctg atctactata cctccaggct gcatagcgga      960

gtgccatctc ggttctctgg atccggaagc ggaaccgact tcacctttac aatctcttcc     1020

ctgcagcccg aggacatcgc cacctactat tgtcagcagg gcaataccct gccttataca     1080

tttggccagg gcaccaaggt ggagatcaag agaacagtgg ccgctccctc cgtgttcatc     1140

tttccccctt ccgacgagca gctgaagtcc ggcaccgcca gcgtggtgtg cctgctgaac     1200

aacttctacc ccagggaggc taaggtgcag tggaaggtgg ataacgccct gcagtccggc     1260

aatagccagg agtctgtgac cgagcaggac tccaaggata gcacatattc tctgtcttcc     1320

accctgacac tgtctaaggc tgattacgag aagcacaagg tgtatgcctg tgaagtcact     1380

catcagggtc tgtccagccc agtcactaag tcattcaacc gtggcgaatg ctga           1434


<210>  46
<211>  472
<212>  PRT
<213>  ˹

<220>
<223>  TLCAһ

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
225                 230                 235                 240 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
                245                 250                 255     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            260                 265                 270         


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        275                 280                 285             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    290                 295                 300                 


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
305                 310                 315                 320 


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            340                 345                 350         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
        355                 360                 365             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala 
    370                 375                 380                 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
385                 390                 395                 400 


Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
                405                 410                 415     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
            420                 425                 430         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        435                 440                 445             


Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln 
    450                 455                 460                 


Gly Thr Leu Val Thr Val Ser Ser 
465                 470         


<210>  47
<211>  1419
<212>  DNA
<213>  ˹

<220>
<223>  TLCAһ

<400>  47
gacatccaga tgacccagtc tccaagctct ctgtccgcta gcgtgggcga cagagtgacc       60

atcacatgcc gcgcctccca ggacatctcc agctacctga actggtatca gcagaagcca      120

ggcaaggctc ccaagctgct gatctactat acctccaggc tgcatagcgg agtgccatct      180

cggttctctg gatccggaag cggaaccgac ttcaccttta caatctcttc cctgcagccc      240

gaggacatcg ccacctacta ttgtcagcag ggcaataccc tgccttatac atttggccag      300

ggcaccaagg tggagatcaa gagaacagtg gccgctccct ccgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ctaaggtgca gtggaaggtg gataacgccc tgcagtccgg caatagccag      480

gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca      540

ctgtctaagg ctgattacga gaagcacaag gtgtatgcct gtgaagtcac tcatcagggt      600

ctgtccagcc cagtcactaa gtcattcaac cgtggcgaat gcggaggagg aggaagcggt      660

ggcggcggct ctgatattca gatgactcag tccccttcta gtctgtccgc ctctgtgggc      720

gacagagtga ccatcacatg cagggccagc cagggcatcc ggaactacct ggcttggtat      780

cagcagaagc caggcaaggc ccccaagctg ctgatctacg ccgcttccac cctgcaaagc      840

ggagtgccat ctcggttctc cggcagcggc tctggcacag actttaccct gacaatctcc      900

agcctgcagc ctgaggatgt ggctacctac tattgccaga ggtacaatcg ggccccatat      960

accttcggct gcggcacaaa ggtggagatc aagggcggcg gcggctctgg cggcggcggc     1020

tctggtggcg gcggcagtgg cggcggcggc tctgaagtcc agctggtcga aagcgggggg     1080

gggctggtgc agcctggcag gtctctgcgg ctgtcctgcg ccgctagcgg cttcaccttt     1140

gacgattacg ccatgcactg ggtgagacag gctccaggca agtgcctgga gtgggtgagc     1200

gccatcacct ggaactctgg ccatatcgac tacgctgata gcgtggaggg cagattcaca     1260

atctctaggg acaacgccaa gaactccctg tatctgcaaa tgaatagcct gagggccgag     1320

gataccgccg tgtactattg cgccaaggtg tcttacctga gcaccgcttc cagcctggac     1380

tattggggcc agggcaccct ggtgacagtg tcttcctga                            1419


<210>  48
<211>  449
<212>  PRT
<213>  ˹

<220>
<223>  TLNATLCAڶ

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  49
<211>  1347
<212>  DNA
<213>  ˹

<220>
<223>  TLNATLCAڶ

<400>  49
caggtgcagc tgcaggagag cggacctgga ctggtgagac caagccagac cctgtctctg       60

acctgcacag tgtctggcta ctccatcaca agcgatcacg cttggtcttg ggtgagacag      120

ccacctggaa ggggactgga gtggatcggc tacatcagct attctggcat caccacatat      180

aacccctctc tgaagtccag ggtgaccatg ctgcgggaca catccaagaa tcagttcagc      240

ctgaggctgt ccagcgtgac cgctgctgat acagccgtgt actattgtgc caggtccctg      300

gctcggacca cagccatgga ctactgggga cagggatccc tggtgaccgt gtcttccgcc      360

tctacaaagg gcccctccgt gtttccactg gctccctcct ctaagagcac ctctggcggc      420

acagccgctc tgggctgtct ggtgaaggat tacttcccag agcccgtgac agtgagctgg      480

aactctggcg ccctgacctc tggagtgcac acatttccag ctgtgctgca gtccagcggc      540

ctgtactccc tgtcttccgt ggtgaccgtg cccagctctt ccctgggcac ccagacatat      600

atctgcaacg tgaaccacaa gccatccaat acaaaggtgg acaagaaggt ggagcccaag      660

tcctgtgata agacccatac atgcccccct tgtcctgctc cagagctgct gggaggacct      720

tccgtgttcc tgtttccacc caaacctaag gacaccctga tgatcagcag gacccccgag      780

gtgacatgcg tggtggtgga cgtgtctcac gaggatcccg aggtgaagtt caactggtat      840

gtcgatggcg tggaggtgca taatgctaag accaagcctc gggaggagca gtacaactcc      900

acctatagag tggtgagcgt gctgacagtg ctgcatcagg actggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg cccgctccca tcgagaagac catcagcaag     1020

gccaagggcc agccaaggga gccacaggtg tacacactgc ctccatcccg ggacgagctg     1080

accaagaacc aggtgagcct gacatgtctg gtgaagggct tctatcctag cgatatcgct     1140

gtggagtggg agtccaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1200

gactccgatg gcagcttctt tctgtattct aagctgaccg tggataagtc ccggtggcag     1260

cagggcaacg tgttctcctg tagcgtgatg cacgaagccc tgcataatca ctatactcag     1320

aaaagtctgt cactgtcacc tggtaaa                                         1347


<210>  50
<211>  712
<212>  PRT
<213>  ˹

<220>
<223>  ANTһ

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His 
145                 150                 155                 160 


Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                325                 330                 335     


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser 
        355                 360                 365             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        435                 440                 445             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


<210>  51
<211>  2139
<212>  DNA
<213>  ˹

<220>
<223>  ANTһ

<400>  51
gacatccaga tgacccagtc tccaagctct ctgtccgcta gcgtgggcga cagagtgacc       60

atcacatgcc gcgcctccca ggacatctcc agctacctga actggtatca gcagaagcca      120

ggcaaggctc ccaagctgct gatctactat acctccaggc tgcatagcgg agtgccatct      180

cggttctctg gatccggaag cggaaccgac ttcaccttta caatctcttc cctgcagccc      240

gaggacatcg ccacctacta ttgtcagcag ggcaataccc tgccttatac atttggctgc      300

ggcaccaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tcaggtgcag ctgcaggaga gcggacctgg actggtgaga      420

ccaagccaga ccctgtctct gacctgcaca gtgtctggct actccatcac aagcgatcac      480

gcttggtctt gggtgagaca gccacctgga aggtgcctgg agtggatcgg ctacatcagc      540

tattctggca tcaccacata taacccctct ctgaagtcca gggtgaccat gctgcgggac      600

acatccaaga atcagttcag cctgaggctg tccagcgtga ccgctgctga tacagccgtg      660

tactattgtg ccaggtccct ggctcggacc acagccatgg actactgggg acagggatcc      720

ctggtgaccg tgtcttccgg aggaggagga tccggaggag gaggaagcgg tggcggcggc      780

tctgaagtcc agctggtcga aagcgggggg gggctggtgc agcctggcag gtctctgcgg      840

ctgtcctgcg ccgctagcgg cttcaccttt gacgattacg ccatgcactg ggtgagacag      900

gctccaggca agggcctgga gtgggtgagc gccatcacct ggaactctgg ccatatcgac      960

tacgctgata gcgtggaggg cagattcaca atctctaggg acaacgccaa gaactccctg     1020

tatctgcaaa tgaatagcct gagggccgag gataccgccg tgtactattg cgccaaggtg     1080

tcttacctga gcaccgcttc cagcctggac tattggggcc agggcaccct ggtgacagtg     1140

tcttccgcct ctacaaaggg cccctccgtg tttccactgg ctccctcctc taagagcacc     1200

tctggcggca cagccgctct gggctgtctg gtgaaggatt acttcccaga gcccgtgaca     1260

gtgagctgga actctggcgc cctgacctct ggagtgcaca catttccagc tgtgctgcag     1320

tccagcggcc tgtactccct gtcttccgtg gtgaccgtgc ccagctcttc cctgggcacc     1380

cagacatata tctgcaacgt gaaccacaag ccatccaata caaaggtgga caagaaggtg     1440

gagcccaagt cctgtgataa gacccataca tgcccccctt gtcctgctcc agagctgctg     1500

ggaggacctt ccgtgttcct gtttccaccc aaacctaagg acaccctgat gatcagcagg     1560

acccccgagg tgacatgcgt ggtggtggac gtgtctcacg aggatcccga ggtgaagttc     1620

aactggtatg tcgatggcgt ggaggtgcat aatgctaaga ccaagcctcg ggaggagcag     1680

tacaactcca cctatagagt ggtgagcgtg ctgacagtgc tgcatcagga ctggctgaac     1740

ggcaaggagt ataagtgcaa ggtgtccaat aaggccctgc ccgctcccat cgagaagacc     1800

atcagcaagg ccaagggcca gccaagggag ccacaggtgt acacactgcc tccatcccgg     1860

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctatcctagc     1920

gatatcgctg tggagtggga gtccaatggc cagccagaga acaattacaa gaccacaccc     1980

cctgtgctgg actccgatgg cagcttcttt ctgtattcta agctgaccgt ggataagtcc     2040

cggtggcagc agggcaacgt gttctcctgt agcgtgatgc acgaagccct gcataatcac     2100

tatactcaga aaagtctgtc actgtcacct ggtaaatga                            2139


<210>  52
<211>  706
<212>  PRT
<213>  ˹

<220>
<223>  ACTһ

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    450                 455                 460                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr 
                485                 490                 495     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser 
            500                 505                 510         


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        515                 520                 525             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    530                 535                 540                 


Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys 
545                 550                 555                 560 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
            580                 585                 590         


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
        595                 600                 605             


Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser Trp 
    610                 615                 620                 


Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile Gly Tyr Ile Ser 
625                 630                 635                 640 


Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
                645                 650                 655     


Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser 
            660                 665                 670         


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Leu Ala 
        675                 680                 685             


Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210>  53
<211>  2121
<212>  DNA
<213>  ˹

<220>
<223>  ACTһ

<400>  53
gaagtccagc tggtcgaaag cggggggggg ctggtgcagc ctggcaggtc tctgcggctg       60

tcctgcgccg ctagcggctt cacctttgac gattacgcca tgcactgggt gagacaggct      120

ccaggcaagg gcctggagtg ggtgagcgcc atcacctgga actctggcca tatcgactac      180

gctgatagcg tggagggcag attcacaatc tctagggaca acgccaagaa ctccctgtat      240

ctgcaaatga atagcctgag ggccgaggat accgccgtgt actattgcgc caaggtgtct      300

tacctgagca ccgcttccag cctggactat tggggccagg gcaccctggt gacagtgtct      360

tccgcctcta caaagggccc ctccgtgttt ccactggctc cctcctctaa gagcacctct      420

ggcggcacag ccgctctggg ctgtctggtg aaggattact tcccagagcc cgtgacagtg      480

agctggaact ctggcgccct gacctctgga gtgcacacat ttccagctgt gctgcagtcc      540

agcggcctgt actccctgtc ttccgtggtg accgtgccca gctcttccct gggcacccag      600

acatatatct gcaacgtgaa ccacaagcca tccaatacaa aggtggacaa gaaggtggag      660

cccaagtcct gtgataagac ccatacatgc cccccttgtc ctgctccaga gctgctggga      720

ggaccttccg tgttcctgtt tccacccaaa cctaaggaca ccctgatgat cagcaggacc      780

cccgaggtga catgcgtggt ggtggacgtg tctcacgagg atcccgaggt gaagttcaac      840

tggtatgtcg atggcgtgga ggtgcataat gctaagacca agcctcggga ggagcagtac      900

aactccacct atagagtggt gagcgtgctg acagtgctgc atcaggactg gctgaacggc      960

aaggagtata agtgcaaggt gtccaataag gccctgcccg ctcccatcga gaagaccatc     1020

agcaaggcca agggccagcc aagggagcca caggtgtaca cactgcctcc atcccgggac     1080

gagctgacca agaaccaggt gagcctgaca tgtctggtga agggcttcta tcctagcgat     1140

atcgctgtgg agtgggagtc caatggccag ccagagaaca attacaagac cacaccccct     1200

gtgctggact ccgatggcag cttctttctg tattctaagc tgaccgtgga taagtcccgg     1260

tggcagcagg gcaacgtgtt ctcctgtagc gtgatgcacg aagccctgca taatcactat     1320

actcagaaaa gtctgtcact gtcacctggt ggaggaggag gatccggagg aggaggaagc     1380

gacatccaga tgacccagtc tccaagctct ctgtccgcta gcgtgggcga cagagtgacc     1440

atcacatgcc gcgcctccca ggacatctcc agctacctga actggtatca gcagaagcca     1500

ggcaaggctc ccaagctgct gatctactat acctccaggc tgcatagcgg agtgccatct     1560

cggttctctg gatccggaag cggaaccgac ttcaccttta caatctcttc cctgcagccc     1620

gaggacatcg ccacctacta ttgtcagcag ggcaataccc tgccttatac atttggctgc     1680

ggcaccaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc     1740

ggcagtggcg gcggcggctc tcaggtgcag ctgcaggaga gcggacctgg actggtgaga     1800

ccaagccaga ccctgtctct gacctgcaca gtgtctggct actccatcac aagcgatcac     1860

gcttggtctt gggtgagaca gccacctgga aggtgcctgg agtggatcgg ctacatcagc     1920

tattctggca tcaccacata taacccctct ctgaagtcca gggtgaccat gctgcgggac     1980

acatccaaga atcagttcag cctgaggctg tccagcgtga ccgctgctga tacagccgtg     2040

tactattgtg ccaggtccct ggctcggacc acagccatgg actactgggg acagggatcc     2100

ctggtgaccg tgtcttcctg a                                               2121


<210>  54
<211>  246
<212>  PRT
<213>  ˹

<220>
<223>  ANTACTscFv

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His 
145                 150                 155                 160 


Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  55
<211>  744
<212>  DNA
<213>  ˹

<220>
<223>  ANTACTscFvı

<400>  55
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggctgc      300

ggcacaaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tgaagtccag ctggtcgaaa gcgggggggg gctggtgcag      420

cctggcaggt ctctgcggct gtcctgcgcc gctagcggct tcacctttga cgattacgcc      480

atgcactggg tgagacaggc tccaggcaag tgcctggagt gggtgagcgc catcacctgg      540

aactctggcc atatcgacta cgctgatagc gtggagggca gattcacaat ctctagggac      600

aacgccaaga actccctgta tctgcaaatg aatagcctga gggccgagga taccgccgtg      660

tactattgcg ccaaggtgtc ttacctgagc accgcttcca gcctggacta ttggggccag      720

ggcaccctgg tgacagtgtc ttcc                                             744


<210>  56
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ANTACTڶ

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  57
<211>  645
<212>  DNA
<213>  ˹

<220>
<223>  ANTACTڶ

<400>  57
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggccaa      300

ggcacaaagg tggagatcaa gagaacagtg gccgctccct ccgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ctaaggtgca gtggaaggtg gataacgccc tgcagtccgg caatagccag      480

gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca      540

ctgtctaagg ctgattacga gaagcacaag gtgtatgcct gtgaagtcac tcatcagggt      600

ctgtccagcc cagtcactaa gtcattcaac cgtggcgaat gctga                      645


<210>  58
<211>  712
<212>  PRT
<213>  ˹

<220>
<223>  ANT-2һ

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            180                 185                 190         


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                325                 330                 335     


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser 
        355                 360                 365             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        435                 440                 445             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


<210>  59
<211>  2139
<212>  DNA
<213>  ˹

<220>
<223>  ANT-2һ

<400>  59
caggtgcagc tgcaggagag cggacctgga ctggtgagac caagccagac cctgtctctg       60

acctgcacag tgtctggcta ctccatcaca agcgatcacg cttggtcttg ggtgagacag      120

ccacctggaa ggtgcctgga gtggatcggc tacatcagct attctggcat caccacatat      180

aacccctctc tgaagtccag ggtgaccatg ctgcgggaca catccaagaa tcagttcagc      240

ctgaggctgt ccagcgtgac cgctgctgat acagccgtgt actattgtgc caggtccctg      300

gctcggacca cagccatgga ctactgggga cagggatccc tggtgaccgt gtcttccggc      360

ggcggcggct ctggcggcgg cggctctggt ggcggcggca gtggcggcgg cggctctgac      420

atccagatga cccagtctcc aagctctctg tccgctagcg tgggcgacag agtgaccatc      480

acatgccgcg cctcccagga catctccagc tacctgaact ggtatcagca gaagccaggc      540

aaggctccca agctgctgat ctactatacc tccaggctgc atagcggagt gccatctcgg      600

ttctctggat ccggaagcgg aaccgacttc acctttacaa tctcttccct gcagcccgag      660

gacatcgcca cctactattg tcagcagggc aataccctgc cttatacatt tggctgcggc      720

accaaggtgg agatcaaggg aggaggagga tccggaggag gaggaagcgg tggcggcggc      780

tctgaagtcc agctggtcga aagcgggggg gggctggtgc agcctggcag gtctctgcgg      840

ctgtcctgcg ccgctagcgg cttcaccttt gacgattacg ccatgcactg ggtgagacag      900

gctccaggca agggcctgga gtgggtgagc gccatcacct ggaactctgg ccatatcgac      960

tacgctgata gcgtggaggg cagattcaca atctctaggg acaacgccaa gaactccctg     1020

tatctgcaaa tgaatagcct gagggccgag gataccgccg tgtactattg cgccaaggtg     1080

tcttacctga gcaccgcttc cagcctggac tattggggcc agggcaccct ggtgacagtg     1140

tcttccgcct ctacaaaggg cccctccgtg tttccactgg ctccctcctc taagagcacc     1200

tctggcggca cagccgctct gggctgtctg gtgaaggatt acttcccaga gcccgtgaca     1260

gtgagctgga actctggcgc cctgacctct ggagtgcaca catttccagc tgtgctgcag     1320

tccagcggcc tgtactccct gtcttccgtg gtgaccgtgc ccagctcttc cctgggcacc     1380

cagacatata tctgcaacgt gaaccacaag ccatccaata caaaggtgga caagaaggtg     1440

gagcccaagt cctgtgataa gacccataca tgcccccctt gtcctgctcc agagctgctg     1500

ggaggacctt ccgtgttcct gtttccaccc aaacctaagg acaccctgat gatcagcagg     1560

acccccgagg tgacatgcgt ggtggtggac gtgtctcacg aggatcccga ggtgaagttc     1620

aactggtatg tcgatggcgt ggaggtgcat aatgctaaga ccaagcctcg ggaggagcag     1680

tacaactcca cctatagagt ggtgagcgtg ctgacagtgc tgcatcagga ctggctgaac     1740

ggcaaggagt ataagtgcaa ggtgtccaat aaggccctgc ccgctcccat cgagaagacc     1800

atcagcaagg ccaagggcca gccaagggag ccacaggtgt acacactgcc tccatcccgg     1860

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctatcctagc     1920

gatatcgctg tggagtggga gtccaatggc cagccagaga acaattacaa gaccacaccc     1980

cctgtgctgg actccgatgg cagcttcttt ctgtattcta agctgaccgt ggataagtcc     2040

cggtggcagc agggcaacgt gttctcctgt agcgtgatgc acgaagccct gcataatcac     2100

tatactcaga aaagtctgtc actgtcacct ggtaaatga                            2139


<210>  60
<211>  706
<212>  PRT
<213>  ˹

<220>
<223>  ACT-2һ

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    450                 455                 460                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
465                 470                 475                 480 


Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser 
                485                 490                 495     


Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile Gly Tyr Ile 
            500                 505                 510         


Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Val 
        515                 520                 525             


Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser 
    530                 535                 540                 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Leu 
545                 550                 555                 560 


Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr 
                565                 570                 575     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
        595                 600                 605             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    610                 615                 620                 


Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
                645                 650                 655     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
            660                 665                 670         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
        675                 680                 685             


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys Gly Thr Lys Val Glu 
    690                 695                 700                 


Ile Lys 
705     


<210>  61
<211>  2121
<212>  DNA
<213>  ˹

<220>
<223>  ACT-2һ

<400>  61
gaagtccagc tggtcgaaag cggggggggg ctggtgcagc ctggcaggtc tctgcggctg       60

tcctgcgccg ctagcggctt cacctttgac gattacgcca tgcactgggt gagacaggct      120

ccaggcaagg gcctggagtg ggtgagcgcc atcacctgga actctggcca tatcgactac      180

gctgatagcg tggagggcag attcacaatc tctagggaca acgccaagaa ctccctgtat      240

ctgcaaatga atagcctgag ggccgaggat accgccgtgt actattgcgc caaggtgtct      300

tacctgagca ccgcttccag cctggactat tggggccagg gcaccctggt gacagtgtct      360

tccgcctcta caaagggccc ctccgtgttt ccactggctc cctcctctaa gagcacctct      420

ggcggcacag ccgctctggg ctgtctggtg aaggattact tcccagagcc cgtgacagtg      480

agctggaact ctggcgccct gacctctgga gtgcacacat ttccagctgt gctgcagtcc      540

agcggcctgt actccctgtc ttccgtggtg accgtgccca gctcttccct gggcacccag      600

acatatatct gcaacgtgaa ccacaagcca tccaatacaa aggtggacaa gaaggtggag      660

cccaagtcct gtgataagac ccatacatgc cccccttgtc ctgctccaga gctgctggga      720

ggaccttccg tgttcctgtt tccacccaaa cctaaggaca ccctgatgat cagcaggacc      780

cccgaggtga catgcgtggt ggtggacgtg tctcacgagg atcccgaggt gaagttcaac      840

tggtatgtcg atggcgtgga ggtgcataat gctaagacca agcctcggga ggagcagtac      900

aactccacct atagagtggt gagcgtgctg acagtgctgc atcaggactg gctgaacggc      960

aaggagtata agtgcaaggt gtccaataag gccctgcccg ctcccatcga gaagaccatc     1020

agcaaggcca agggccagcc aagggagcca caggtgtaca cactgcctcc atcccgggac     1080

gagctgacca agaaccaggt gagcctgaca tgtctggtga agggcttcta tcctagcgat     1140

atcgctgtgg agtgggagtc caatggccag ccagagaaca attacaagac cacaccccct     1200

gtgctggact ccgatggcag cttctttctg tattctaagc tgaccgtgga taagtcccgg     1260

tggcagcagg gcaacgtgtt ctcctgtagc gtgatgcacg aagccctgca taatcactat     1320

actcagaaaa gtctgtcact gtcacctggt ggaggaggag gatccggagg aggaggaagc     1380

caggtgcagc tgcaggagag cggacctgga ctggtgagac caagccagac cctgtctctg     1440

acctgcacag tgtctggcta ctccatcaca agcgatcacg cttggtcttg ggtgagacag     1500

ccacctggaa ggtgcctgga gtggatcggc tacatcagct attctggcat caccacatat     1560

aacccctctc tgaagtccag ggtgaccatg ctgcgggaca catccaagaa tcagttcagc     1620

ctgaggctgt ccagcgtgac cgctgctgat acagccgtgt actattgtgc caggtccctg     1680

gctcggacca cagccatgga ctactgggga cagggatccc tggtgaccgt gtcttccggc     1740

ggcggcggct ctggcggcgg cggctctggt ggcggcggca gtggcggcgg cggctctgac     1800

atccagatga cccagtctcc aagctctctg tccgctagcg tgggcgacag agtgaccatc     1860

acatgccgcg cctcccagga catctccagc tacctgaact ggtatcagca gaagccaggc     1920

aaggctccca agctgctgat ctactatacc tccaggctgc atagcggagt gccatctcgg     1980

ttctctggat ccggaagcgg aaccgacttc acctttacaa tctcttccct gcagcccgag     2040

gacatcgcca cctactattg tcagcagggc aataccctgc cttatacatt tggctgcggc     2100

accaaggtgg agatcaagtg a                                               2121


<210>  62
<211>  246
<212>  PRT
<213>  ˹

<220>
<223>  ANT-2ACT-2scFv

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            180                 185                 190         


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  63
<211>  738
<212>  DNA
<213>  ˹

<220>
<223>  ANT-2ACT-2scFvı

<400>  63
caggtgcagc tgcaggagag cggacctgga ctggtgagac caagccagac cctgtctctg       60

acctgcacag tgtctggcta ctccatcaca agcgatcacg cttggtcttg ggtgagacag      120

ccacctggaa ggtgcctgga gtggatcggc tacatcagct attctggcat caccacatat      180

aacccctctc tgaagtccag ggtgaccatg ctgcgggaca catccaagaa tcagttcagc      240

ctgaggctgt ccagcgtgac cgctgctgat acagccgtgt actattgtgc caggtccctg      300

gctcggacca cagccatgga ctactgggga cagggatccc tggtgaccgt gtcttccggc      360

ggcggcggct ctggcggcgg cggctctggt ggcggcggca gtggcggcgg cggctctgac      420

atccagatga cccagtctcc aagctctctg tccgctagcg tgggcgacag agtgaccatc      480

acatgccgcg cctcccagga catctccagc tacctgaact ggtatcagca gaagccaggc      540

aaggctccca agctgctgat ctactatacc tccaggctgc atagcggagt gccatctcgg      600

ttctctggat ccggaagcgg aaccgacttc acctttacaa tctcttccct gcagcccgag      660

gacatcgcca cctactattg tcagcagggc aataccctgc cttatacatt tggctgcggc      720

accaaggtgg agatcaag                                                    738


<210>  64
<211>  475
<212>  PRT
<213>  ˹

<220>
<223>  ALNTһ

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His 
145                 150                 155                 160 


Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        195                 200                 205             


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            260                 265                 270         


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        275                 280                 285             


Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    290                 295                 300                 


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro 
305                 310                 315                 320 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                325                 330                 335     


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr 
            340                 345                 350         


Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        355                 360                 365             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    370                 375                 380                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
385                 390                 395                 400 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                405                 410                 415     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            420                 425                 430         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        435                 440                 445             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    450                 455                 460                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475 


<210>  65
<211>  1428
<212>  DNA
<213>  ˹

<220>
<223>  ALNTһ

<400>  65
gacatccaga tgacccagtc tccaagctct ctgtccgcta gcgtgggcga cagagtgacc       60

atcacatgcc gcgcctccca ggacatctcc agctacctga actggtatca gcagaagcca      120

ggcaaggctc ccaagctgct gatctactat acctccaggc tgcatagcgg agtgccatct      180

cggttctctg gatccggaag cggaaccgac ttcaccttta caatctcttc cctgcagccc      240

gaggacatcg ccacctacta ttgtcagcag ggcaataccc tgccttatac atttggctgc      300

ggcaccaagg tggagatcaa gggcggcggc ggctctggcg gcggcggctc tggtggcggc      360

ggcagtggcg gcggcggctc tcaggtgcag ctgcaggaga gcggacctgg actggtgaga      420

ccaagccaga ccctgtctct gacctgcaca gtgtctggct actccatcac aagcgatcac      480

gcttggtctt gggtgagaca gccacctgga aggtgcctgg agtggatcgg ctacatcagc      540

tattctggca tcaccacata taacccctct ctgaagtcca gggtgaccat gctgcgggac      600

acatccaaga atcagttcag cctgaggctg tccagcgtga ccgctgctga tacagccgtg      660

tactattgtg ccaggtccct ggctcggacc acagccatgg actactgggg acagggatcc      720

ctggtgaccg tgtcttccgg aggaggagga tccggaggag gaggaagcgg tggcggcggc      780

tctgatattc agatgactca gtccccttct agtctgtccg cctctgtggg cgacagagtg      840

accatcacat gcagggccag ccagggcatc cggaactacc tggcttggta tcagcagaag      900

ccaggcaagg cccccaagct gctgatctac gccgcttcca ccctgcaaag cggagtgcca      960

tctcggttct ccggcagcgg ctctggcaca gactttaccc tgacaatctc cagcctgcag     1020

cctgaggatg tggctaccta ctattgccag aggtacaatc gggccccata taccttcggc     1080

caaggcacaa aggtggagat caagagaaca gtggccgctc cctccgtgtt catctttccc     1140

ccttccgacg agcagctgaa gtccggcacc gccagcgtgg tgtgcctgct gaacaacttc     1200

taccccaggg aggctaaggt gcagtggaag gtggataacg ccctgcagtc cggcaatagc     1260

caggagtctg tgaccgagca ggactccaag gatagcacat attctctgtc ttccaccctg     1320

acactgtcta aggctgatta cgagaagcac aaggtgtatg cctgtgaagt cactcatcag     1380

ggtctgtcca gcccagtcac taagtcattc aaccgtggcg aatgctga                  1428


<210>  66
<211>  470
<212>  PRT
<213>  ˹

<220>
<223>  ALCTһ

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
225                 230                 235                 240 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
                245                 250                 255     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            260                 265                 270         


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
        275                 280                 285             


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
    290                 295                 300                 


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
305                 310                 315                 320 


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
            340                 345                 350         


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr 
        355                 360                 365             


Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp His 
    370                 375                 380                 


Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp Ile 
385                 390                 395                 400 


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu Lys 
                405                 410                 415     


Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
            420                 425                 430         


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
        435                 440                 445             


Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly Ser 
    450                 455                 460                 


Leu Val Thr Val Ser Ser 
465                 470 


<210>  67
<211>  1413
<212>  DNA
<213>  ˹

<220>
<223>  ALCTһ

<400>  67
gatattcaga tgactcagtc cccttctagt ctgtccgcct ctgtgggcga cagagtgacc       60

atcacatgca gggccagcca gggcatccgg aactacctgg cttggtatca gcagaagcca      120

ggcaaggccc ccaagctgct gatctacgcc gcttccaccc tgcaaagcgg agtgccatct      180

cggttctccg gcagcggctc tggcacagac tttaccctga caatctccag cctgcagcct      240

gaggatgtgg ctacctacta ttgccagagg tacaatcggg ccccatatac cttcggccaa      300

ggcacaaagg tggagatcaa gagaacagtg gccgctccct ccgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ctaaggtgca gtggaaggtg gataacgccc tgcagtccgg caatagccag      480

gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca      540

ctgtctaagg ctgattacga gaagcacaag gtgtatgcct gtgaagtcac tcatcagggt      600

ctgtccagcc cagtcactaa gtcattcaac cgtggcgaat gcggaggagg aggatccgga      660

ggaggaggaa gcgacatcca gatgacccag tctccaagct ctctgtccgc tagcgtgggc      720

gacagagtga ccatcacatg ccgcgcctcc caggacatct ccagctacct gaactggtat      780

cagcagaagc caggcaaggc tcccaagctg ctgatctact atacctccag gctgcatagc      840

ggagtgccat ctcggttctc tggatccgga agcggaaccg acttcacctt tacaatctct      900

tccctgcagc ccgaggacat cgccacctac tattgtcagc agggcaatac cctgccttat      960

acatttggct gcggcaccaa ggtggagatc aagggcggcg gcggctctgg cggcggcggc     1020

tctggtggcg gcggcagtgg cggcggcggc tctcaggtgc agctgcagga gagcggacct     1080

ggactggtga gaccaagcca gaccctgtct ctgacctgca cagtgtctgg ctactccatc     1140

acaagcgatc acgcttggtc ttgggtgaga cagccacctg gaaggtgcct ggagtggatc     1200

ggctacatca gctattctgg catcaccaca tataacccct ctctgaagtc cagggtgacc     1260

atgctgcggg acacatccaa gaatcagttc agcctgaggc tgtccagcgt gaccgctgct     1320

gatacagccg tgtactattg tgccaggtcc ctggctcgga ccacagccat ggactactgg     1380

ggacagggat ccctggtgac cgtgtcttcc tga                                  1413


<210>  68
<211>  451
<212>  PRT
<213>  ˹

<220>
<223>  ALNTALCTĵڶ

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  69
<211>  1356
<212>  DNA
<213>  ˹

<220>
<223>  ALNTALCTĵڶ

<400>  69
gaagtccagc tggtcgaaag cggggggggg ctggtgcagc ctggcaggtc tctgcggctg       60

tcctgcgccg ctagcggctt cacctttgac gattacgcca tgcactgggt gagacaggct      120

ccaggcaagg gcctggagtg ggtgagcgcc atcacctgga actctggcca tatcgactac      180

gctgatagcg tggagggcag attcacaatc tctagggaca acgccaagaa ctccctgtat      240

ctgcaaatga atagcctgag ggccgaggat accgccgtgt actattgcgc caaggtgtct      300

tacctgagca ccgcttccag cctggactat tggggccagg gcaccctggt gacagtgtct      360

tccgcctcta caaagggccc ctccgtgttt ccactggctc cctcctctaa gagcacctct      420

ggcggcacag ccgctctggg ctgtctggtg aaggattact tcccagagcc cgtgacagtg      480

agctggaact ctggcgccct gacctctgga gtgcacacat ttccagctgt gctgcagtcc      540

agcggcctgt actccctgtc ttccgtggtg accgtgccca gctcttccct gggcacccag      600

acatatatct gcaacgtgaa ccacaagcca tccaatacaa aggtggacaa gaaggtggag      660

cccaagtcct gtgataagac ccatacatgc cccccttgtc ctgctccaga gctgctggga      720

ggaccttccg tgttcctgtt tccacccaaa cctaaggaca ccctgatgat cagcaggacc      780

cccgaggtga catgcgtggt ggtggacgtg tctcacgagg atcccgaggt gaagttcaac      840

tggtatgtcg atggcgtgga ggtgcataat gctaagacca agcctcggga ggagcagtac      900

aactccacct atagagtggt gagcgtgctg acagtgctgc atcaggactg gctgaacggc      960

aaggagtata agtgcaaggt gtccaataag gccctgcccg ctcccatcga gaagaccatc     1020

agcaaggcca agggccagcc tagggagcca caggtgtaca cactgcctcc atcccgggac     1080

gagctgacca agaaccaggt gagcctgaca tgtctggtga agggcttcta tcctagcgat     1140

atcgctgtgg agtgggagtc caatggccag ccagagaaca attacaagac cacaccccct     1200

gtgctggact ccgatggcag cttctttctg tattctaagc tgaccgtgga taagtcccgg     1260

tggcagcagg gcaacgtgtt ctcctgtagc gtgatgcacg aagccctgca taatcactat     1320

actcagaaaa gtctgtcact gtcacctggt aaatga                               1356


<210>  70
<211>  709
<212>  PRT
<213>  ˹

<220>
<223>  SCGһ

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    450                 455                 460                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
465                 470                 475                 480 


Ser Gln Ser Val Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                485                 490                 495     


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
            500                 505                 510         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        515                 520                 525             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    530                 535                 540                 


Gln Arg Ser Asn Trp Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
545                 550                 555                 560 


Asp Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            580                 585                 590         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        595                 600                 605             


Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
    610                 615                 620                 


Gly Lys Gly Leu Glu Trp Val Ala Phe Met Ser Tyr Asp Gly Ser Asn 
625                 630                 635                 640 


Lys Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                645                 650                 655     


Asn Pro Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            660                 665                 670         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Ile Ala Ala Gly 
        675                 680                 685             


Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
    690                 695                 700                 


Val Thr Val Ser Ser 
705                 


<210>  71
<211>  2130
<212>  DNA
<213>  ˹

<220>
<223>  SCGһ

<400>  71
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcaggtt caccttcgac gactacgcca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcggc atcagctgga acagcggcag gatcggctac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acgccgagaa cagcctgttc      240

ctgcagatga acggcctgag ggccgaggac accgccctgt actactgcgc caagggcagg      300

gacagcttcg acatctgggg ccagggcacc atggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgagctgc tgggcggccc cagcgtgttc      720

ctgttccccc ccaagcccaa ggacaccctg atgatcagca ggacccccga ggtgacctgc      780

gtggtggtgg acgtgagcca cgaggacccc gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaacgccaa gaccaagccc agggaggagc agtacaacag cacctacagg      900

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtgagca acaaggccct gcccgccccc atcgagaaga ccatcagcaa ggccaagggc     1020

cagcccaggg agccccaggt gtacaccctg ccccccagca gggacgagct gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggacagcgac     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcaggtggca gcagggcaac     1260

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1320

agcctgagcc ccggcggcgg cggcggcagc ggcggcggcg gcagcgagat cgtgctgacc     1380

cagagccccg ccaccctgag cctgagcccc ggcgagaggg ccaccctgag ctgcagggcc     1440

agccagagcg tgtacagcta cctggcctgg taccagcaga agcccggcca ggcccccagg     1500

ctgctgatct acgacgccag caacagggcc accggcatcc ccgccaggtt cagcggcagc     1560

ggcagcggca ccgacttcac cctgaccatc agcagcctgg agcccgagga cttcgccgtg     1620

tactactgcc agcagaggag caactggccc cccttcacct tcggccccgg caccaaggtg     1680

gacatcaagg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagcggcggc     1740

ggcggcagcc aggtgcagct ggtggagagc ggcggcggcg tggtgcagcc cggcaggagc     1800

ctgaggctga gctgcgccgc cagcggcttc accttcagca gctacgccat gcactgggtg     1860

aggcaggccc ccggcaaggg cctggagtgg gtggccttca tgagctacga cggcagcaac     1920

aagaagtacg ccgacagcgt gaagggcagg ttcaccatca gcagggacaa ccccaagaac     1980

accctgtacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcgcc     2040

agggacaggg gcatcgccgc cggcggcaac tactactact acggcatgga cgtgtggggc     2100

cagggcacca ccgtgaccgt gagcagctga                                      2130


<210>  72
<211>  254
<212>  PRT
<213>  ˹

<220>
<223>  SCGscFv

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Cys Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
145                 150                 155                 160 


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
                165                 170                 175     


Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 


<210>  73
<211>  765
<212>  DNA
<213>  ˹

<220>
<223>  SCGscFvı

<400>  73
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gagggccacc       60

ctgagctgca gggccagcca gagcgtgtac agctacctgg cctggtacca gcagaagccc      120

ggccaggccc ccaggctgct gatctacgac gccagcaaca gggccaccgg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgccagcag aggagcaact ggcccccctt caccttcggc      300

cccggcacca aggtggacat caagggcggc ggcggcagcg gcggcggcgg cagcggcggc      360

ggcggcagcg gcggcggcgg cagccaggtg cagctggtgg agagcggcgg cggcgtggtg      420

cagcccggca ggagcctgag gctgagctgc gccgccagcg gcttcacctt cagcagctac      480

gccatgcact gggtgaggca ggcccccggc aagggcctgg agtgggtggc cttcatgagc      540

tacgacggca gcaacaagaa gtacgccgac agcgtgaagg gcaggttcac catcagcagg      600

gacaacccca agaacaccct gtacctgcag atgaacagcc tgagggccga ggacaccgcc      660

gtgtactact gcgccaggga caggggcatc gccgccggcg gcaactacta ctactacggc      720

atggacgtgt ggggccaggg caccaccgtg accgtgagca gctga                      765


<210>  74
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  SCGڶ

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  75
<211>  645
<212>  DNA
<213>  ˹

<220>
<223>  SCGڶ

<400>  75
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacggc gccagcagcc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccagctacta ctgccagcag gccaacagct tcccctacac cttcggccag      300

ggcaccaagc tggagatcaa gagaacagtg gccgctccct ccgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ctaaggtgca gtggaaggtg gataacgccc tgcagtccgg caatagccag      480

gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca      540

ctgtctaagg ctgattacga gaagcacaag gtgtatgcct gtgaagtcac tcatcagggt      600

ctgtccagcc cagtcactaa gtcattcaac cgtggcgaat gctga                      645


<210>  76
<211>  708
<212>  PRT
<213>  ˹

<220>
<223>  GCSһ

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 
465                 470                 475                 480 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
                485                 490                 495     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            500                 505                 510         


Ile Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
        515                 520                 525             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    530                 535                 540                 


Pro Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 
545                 550                 555                 560 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
        595                 600                 605             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
    610                 615                 620                 


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
625                 630                 635                 640 


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
                645                 650                 655     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
            660                 665                 670         


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
        675                 680                 685             


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
    690                 695                 700                 


Thr Val Ser Ser 
705             


<210>  77
<211>  2127
<212>  DNA
<213>  ˹

<220>
<223>  GCSһ

<400>  77
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc agctacgcca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccttc atgagctacg acggcagcaa caagaagtac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca accccaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc cagggacagg      300

ggcatcgccg ccggcggcaa ctactactac tacggcatgg acgtgtgggg ccagggcacc      360

accgtgaccg tgagcagcgc cagcaccaag ggccccagcg tgttccccct ggcccccagc      420

agcaagagca ccagcggcgg caccgccgcc ctgggctgcc tggtgaagga ctacttcccc      480

gagcccgtga ccgtgagctg gaacagcggc gccctgacca gcggcgtgca caccttcccc      540

gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgaccgt gcccagcagc      600

agcctgggca cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggagcccaa gagctgcgac aagacccaca cctgcccccc ctgccccgcc      720

cccgagctgc tgggcggccc cagcgtgttc ctgttccccc ccaagcccaa ggacaccctg      780

atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      840

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc      900

agggaggagc agtacaacag cacctacagg gtggtgagcg tgctgaccgt gctgcaccag      960

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgccccc     1020

atcgagaaga ccatcagcaa ggccaagggc cagcccaggg agccccaggt gtacaccctg     1080

ccccccagca gggacgagct gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1140

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1260

gtggacaaga gcaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggcggcgg cggcggcagc     1380

ggcggcggcg gcagcgacat ccagatgacc cagagcccca gcagcgtgag cgccagcgtg     1440

ggcgacaggg tgaccatcac ctgcagggcc agccagggca tcagcagctg gctggcctgg     1500

taccagcaga agcccggcaa ggcccccaag ctgctgatct acggcgccag cagcctggag     1560

agcggcgtgc ccagcaggtt cagcggcagc ggcagcggca ccgacttcac cctgaccatc     1620

agcagcctgc agcccgagga cttcgccagc tactactgcc agcaggccaa cagcttcccc     1680

tacaccttcg gccagggcac caagctggag atcaagggcg gcggcggcag cggcggcggc     1740

ggcagcggcg gcggcggcag cggcggcggc ggcagcgagg tgcagctggt ggagagcggc     1800

ggcggcctgg tgcagcccgg caggagcctg aggctgagct gcgccgccag caggttcacc     1860

ttcgacgact acgccatgca ctgggtgagg caggcccccg gcaagggcct ggagtgggtg     1920

agcggcatca gctggaacag cggcaggatc ggctacgccg acagcgtgaa gggcaggttc     1980

accatcagca gggacaacgc cgagaacagc ctgttcctgc agatgaacgg cctgagggcc     2040

gaggacaccg ccctgtacta ctgcgccaag ggcagggaca gcttcgacat ctggggccag     2100

ggcaccatgg tgaccgtgag cagctga                                         2127


<210>  78
<211>  243
<212>  PRT
<213>  ˹

<220>
<223>  GCSscFv

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr Ala 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe Leu 
        195                 200                 205             


Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  79
<211>  729
<212>  DNA
<213>  ˹

<220>
<223>  GCSscFvı

<400>  79
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacggc gccagcagcc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccagctacta ctgccagcag gccaacagct tcccctacac cttcggccag      300

ggcaccaagc tggagatcaa gggcggcggc ggcagcggcg gcggcggcag cggcggcggc      360

ggcagcggcg gcggcggcag cgaggtgcag ctggtggaga gcggcggcgg cctggtgcag      420

cccggcagga gcctgaggct gagctgcgcc gccagcaggt tcaccttcga cgactacgcc      480

atgcactggg tgaggcaggc ccccggcaag ggcctggagt gggtgagcgg catcagctgg      540

aacagcggca ggatcggcta cgccgacagc gtgaagggca ggttcaccat cagcagggac      600

aacgccgaga acagcctgtt cctgcagatg aacggcctga gggccgagga caccgccctg      660

tactactgcg ccaagggcag ggacagcttc gacatctggg gccagggcac catggtgacc      720

gtgagcagc                                                              729


<210>  80
<211>  215
<212>  PRT
<213>  ˹

<220>
<223>  GCSڶ

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  81
<211>  648
<212>  DNA
<213>  ˹

<220>
<223>  GCSڶ

<400>  81
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gagggccacc       60

ctgagctgca gggccagcca gagcgtgtac agctacctgg cctggtacca gcagaagccc      120

ggccaggccc ccaggctgct gatctacgac gccagcaaca gggccaccgg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgccagcag aggagcaact ggcccccctt caccttcggc      300

cccggcacca aggtggacat caagagaaca gtggccgctc cctccgtgtt catctttccc      360

ccttccgacg agcagctgaa gtccggcacc gccagcgtgg tgtgcctgct gaacaacttc      420

taccccaggg aggctaaggt gcagtggaag gtggataacg ccctgcagtc cggcaatagc      480

caggagtctg tgaccgagca ggactccaag gatagcacat attctctgtc ttccaccctg      540

acactgtcta aggctgatta cgagaagcac aaggtgtatg cctgtgaagt cactcatcag      600

ggtctgtcca gcccagtcac taagtcattc aaccgtggcg aatgctga                   648


<210>  82
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  IgG-KAPPAź

<400>  82

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  83
<211>  57
<212>  DNA
<213>  ˹

<220>
<223>  IgG-KAPPAźı

<400>  83
atgggctggt cttgtattat tctgttcctg gtcgcaactg caaccggcgt ccatagc          57


<210>  84
<211>  449
<212>  PRT
<213>  ˹

<220>
<223>  AB03 

<400>  84

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  85
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  AB01 

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  86
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB01ͻVL

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  87
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  AB01ͻVH

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  108
<212>  PRT
<213>  ˹

<220>
<223>  AB02ͻVL

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Cys Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  89
<211>  126
<212>  PRT
<213>  ˹

<220>
<223>  AB02ͻVH

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  90
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB03ͻVL

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  91
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  AB03ͻVH

<400>  91

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser 
        115                 


<210>  92
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  AB04ͻVL

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  116
<212>  PRT
<213>  ˹

<220>
<223>  AB04ͻVH

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  94
<211>  475
<212>  PRT
<213>  ˹

<220>
<223>  ALNT-2һ

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            180                 185                 190         


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            260                 265                 270         


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        275                 280                 285             


Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    290                 295                 300                 


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro 
305                 310                 315                 320 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                325                 330                 335     


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr 
            340                 345                 350         


Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        355                 360                 365             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    370                 375                 380                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
385                 390                 395                 400 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                405                 410                 415     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            420                 425                 430         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        435                 440                 445             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    450                 455                 460                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475 


<210>  95
<211>  470
<212>  PRT
<213>  ˹

<220>
<223>  ALCT-2һ

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
225                 230                 235                 240 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
                245                 250                 255     


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Cys Leu Glu Trp 
            260                 265                 270         


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
        275                 280                 285             


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
    290                 295                 300                 


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
305                 310                 315                 320 


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
                325                 330                 335     


Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
        355                 360                 365             


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
    370                 375                 380                 


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
385                 390                 395                 400 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
                405                 410                 415     


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            420                 425                 430         


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
        435                 440                 445             


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Cys Gly 
    450                 455                 460                 


Thr Lys Val Glu Ile Lys 
465                 470 


<210>  96
<211>  712
<212>  PRT
<213>  ˹

<220>
<223>  TNA-2һ

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
            260                 265                 270         


Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
        275                 280                 285             


Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser Trp Val Arg Gln Pro 
    290                 295                 300                 


Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ile 
305                 310                 315                 320 


Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Arg Asp 
                325                 330                 335     


Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
            340                 345                 350         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Leu Ala Arg Thr Thr Ala 
        355                 360                 365             


Met Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        435                 440                 445             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


<210>  97
<211>  706
<212>  PRT
<213>  ˹

<220>
<223>  TCA-2һ

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    450                 455                 460                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
465                 470                 475                 480 


Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg 
                485                 490                 495     


Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Thr Trp Asn 
            500                 505                 510         


Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile 
        515                 520                 525             


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
    530                 535                 540                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu 
545                 550                 555                 560 


Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                565                 570                 575     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
        595                 600                 605             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    610                 615                 620                 


Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly 
                645                 650                 655     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            660                 665                 670         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
        675                 680                 685             


Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Cys Gly Thr Lys Val Glu 
    690                 695                 700                 


Ile Lys 
705     


<210>  98
<211>  477
<212>  PRT
<213>  ˹

<220>
<223>  TLNA-2һ

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            260                 265                 270         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        275                 280                 285             


Ser Gln Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
305                 310                 315                 320 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
                325                 330                 335     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    370                 375                 380                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
385                 390                 395                 400 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                405                 410                 415     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            420                 425                 430         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        435                 440                 445             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    450                 455                 460                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475         


<210>  99
<211>  472
<212>  PRT
<213>  ˹

<220>
<223>  TLCA-2һ

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
225                 230                 235                 240 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
                245                 250                 255     


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
            260                 265                 270         


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
        275                 280                 285             


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
    290                 295                 300                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
305                 310                 315                 320 


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
                325                 330                 335     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
        355                 360                 365             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    370                 375                 380                 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala Trp 
385                 390                 395                 400 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
                405                 410                 415     


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            420                 425                 430         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
        435                 440                 445             


Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe Gly 
    450                 455                 460                 


Cys Gly Thr Lys Val Glu Ile Lys 
465                 470         


<210>  100
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  kappaͬ͵CL

<400>  100

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  101
<211>  330
<212>  PRT
<213>  ˹

<220>
<223>  IgG1ͬ͵CH

<400>  101

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         