                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.

<120>  RNAi Agents for Inhibiting Expression of Alpha-ENaC and 
Methods of Use

<130>  30656-WO1

<140>  PCT/US18/40874

<150>  62/529,132
<151>  2017-07-06

<150>  62/631,683
<151>  2018-02-17

<150>  62/679,549
<151>  2018-06-01

<160>  296  

<210>  1
<211>  3345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Sodium channel epithelial 1 alpha subunit (SCNN1A), transcript 
variant 1, GenBank NM_001038.5 

<400>  1
cttgcctgtc tgcgtctaaa gcccctgccc agagtccgcc ttctcaggtc cagtactccc     60

agttcacctg ccctcgggag ccctccttcc ttcggaaaac tcccggctct gactcctcct     120

cagcccctcc ccccgccctg ctcaccttta attgagatgc taatgagatt cctgtcgctt     180

ccatccctgg ccggccagcg ggcgggctcc ccagccaggc cgctgcacct gtcaggggaa     240

caagctggag gagcaggacc ctagacctct gcagcccata ccaggtctca tggaggggaa     300

caagctggag gagcaggact ctagccctcc acagtccact ccagggctca tgaaggggaa     360

caagcgtgag gagcaggggc tgggccccga acctgcggcg ccccagcagc ccacggcgga     420

ggaggaggcc ctgatcgagt tccaccgctc ctaccgagag ctcttcgagt tcttctgcaa     480

caacaccacc atccacggcg ccatccgcct ggtgtgctcc cagcacaacc gcatgaagac     540

ggccttctgg gcagtgctgt ggctctgcac ctttggcatg atgtactggc aattcggcct     600

gcttttcgga gagtacttca gctaccccgt cagcctcaac atcaacctca actcggacaa     660

gctcgtcttc cccgcagtga ccatctgcac cctcaatccc tacaggtacc cggaaattaa     720

agaggagctg gaggagctgg accgcatcac agagcagacg ctctttgacc tgtacaaata     780

cagctccttc accactctcg tggccggctc ccgcagccgt cgcgacctgc gggggactct     840

gccgcacccc ttgcagcgcc tgagggtccc gcccccgcct cacggggccc gtcgagcccg     900

tagcgtggcc tccagcttgc gggacaacaa cccccaggtg gactggaagg actggaagat     960

cggcttccag ctgtgcaacc agaacaaatc ggactgcttc taccagacat actcatcagg     1020

ggtggatgcg gtgagggagt ggtaccgctt ccactacatc aacatcctgt cgaggctgcc     1080

agagactctg ccatccctgg aggaggacac gctgggcaac ttcatcttcg cctgccgctt     1140

caaccaggtc tcctgcaacc aggcgaatta ctctcacttc caccacccga tgtatggaaa     1200

ctgctatact ttcaatgaca agaacaactc caacctctgg atgtcttcca tgcctggaat     1260

caacaacggt ctgtccctga tgctgcgcgc agagcagaat gacttcattc ccctgctgtc     1320

cacagtgact ggggcccggg taatggtgca cgggcaggat gaacctgcct ttatggatga     1380

tggtggcttt aacttgcggc ctggcgtgga gacctccatc agcatgagga aggaaaccct     1440

ggacagactt gggggcgatt atggcgactg caccaagaat ggcagtgatg ttcctgttga     1500

gaacctttac ccttcaaagt acacacagca ggtgtgtatt cactcctgct tccaggagag     1560

catgatcaag gagtgtggct gtgcctacat cttctatccg cggccccaga acgtggagta     1620

ctgtgactac agaaagcaca gttcctgggg gtactgctac tataagctcc aggttgactt     1680

ctcctcagac cacctgggct gtttcaccaa gtgccggaag ccatgcagcg tgaccagcta     1740

ccagctctct gctggttact cacgatggcc ctcggtgaca tcccaggaat gggtcttcca     1800

gatgctatcg cgacagaaca attacaccgt caacaacaag agaaatggag tggccaaagt     1860

caacatcttc ttcaaggagc tgaactacaa aaccaattct gagtctccct ctgtcacgat     1920

ggtcaccctc ctgtccaacc tgggcagcca gtggagcctg tggttcggct cctcggtgtt     1980

gtctgtggtg gagatggctg agctcgtctt tgacctgctg gtcatcatgt tcctcatgct     2040

gctccgaagg ttccgaagcc gatactggtc tccaggccga gggggcaggg gtgctcagga     2100

ggtagcctcc accctggcat cctcccctcc ttcccacttc tgcccccacc ccatgtctct     2160

gtccttgtcc cagccaggcc ctgctccctc tccagccttg acagcccctc cccctgccta     2220

tgccaccctg ggcccccgcc catctccagg gggctctgca ggggccagtt cctccacctg     2280

tcctctgggg gggccctgag agggaaggag aggtttctca caccaaggca gatgctcctc     2340

tggtgggagg gtgctggccc tggcaagatt gaaggatgtg cagggcttcc tctcagagcc     2400

gcccaaactg ccgttgatgt gtggagggga agcaagatgg gtaagggctc aggaagttgc     2460

tccaagaaca gtagctgatg aagctgccca gaagtgcctt ggctccagcc ctgtacccct     2520

tggtactgcc tctgaacact ctggtttccc cacccaactg cggctaagtc tctttttccc     2580

ttggatcagc caagcgaaac ttggagcttt gacaaggaac tttcctaaga aaccgctgat     2640

aaccaggaca aaacacaacc aagggtacac gcaggcatgc acgggtttcc tgcccagcga     2700

cggcttaagc cagcccccga ctggcctggc cacactgctc tccagtagca cagatgtctg     2760

ctcctcctct tgaacttggg tgggaaaccc cacccaaaag ccccctttgt tacttaggca     2820

attccccttc cctgactccc gagggctagg gctagagcag acccgggtaa gtaaaggcag     2880

acccagggct cctctagcct catacccgtg ccctcacaga gccatgcccc ggcacctctg     2940

ccctgtgtct ttcatacctc tacatgtctg cttgagatat ttcctcagcc tgaaagtttc     3000

cccaaccatc tgccagagaa ctcctatgca tcccttagaa ccctgctcag acaccattac     3060

ttttgtgaac gcttctgcca catcttgtct tccccaaaat tgatcactcc gccttctcct     3120

gggctcccgt agcacactat aacatctgct ggagtgttgc tgttgcacca tactttcttg     3180

tacatttgtg tctcccttcc caactagact gtaagtgcct tgcggtcagg gactgaatct     3240

tgcccgttta tgtatgctcc atgtctagcc catcatcctg cttggagcaa gtaggcagga     3300

gctcaataaa tgtttgttgc atgaaggaaa aaaaaaaaaa aaaaa                     3345


<210>  2
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  2
uauuuguucu gguugcacag g                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  3
uauuuguucu gguugcacag g                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  4
ccugugcaac cagaacaaau a                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  5
ccugugcaac cagaacaaau a                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi Agent antisense strand modified sequence

<400>  6
uauuuguucu gguugcacag c                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  7
uauuuguucu gguugcacag c                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  8
gcugugcaac cagaacaaau a                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  9
gcugugcaac cagaacaaau a                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi Agent antisense strand modified sequence

<400>  10
uauuuguucu gguugcacag g                                                 21


<210>  11
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  11
ugugcaacca gaacaaauc                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  12
gugcaaccag aacaaaucg                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  13
gcagagcaga augacuuca                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  14
agagcagaau gacuucauu                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  15
cuaccagaca uacucauca                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  16
ucuaccagac auacucauc                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  17
cuuugaccug uacaaauac                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  18
uggaaggacu ggaagaucg                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  19
ggaaggacug gaagaucgg                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alpha-ENaC gene transcript (mRNA) target sequence

<400>  20
cugugccuac aucuucuau                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  21
uauuuguucu gguugcaca                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  22
aauuuguucu gguugcaca                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  23
gauuuguucu gguugcaca                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  24
nauuuguucu gguugcaca                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  25
nauuuguucu gguugcacn                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  26
aaugaaguca uucugcucu                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  27
uaugaaguca uucugcucu                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  28
naugaaguca uucugcucu                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  29
naugaaguca uucugcucn                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  30
ugaugaguau gucugguag                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  31
ngaugaguau gucugguag                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  32
ngaugaguau gucugguan                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  33
gaugaguaug ucugguaga                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  34
uaugaguaug ucugguaga                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  35
naugaguaug ucugguaga                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  36
naugaguaug ucugguagn                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  37
cgauuuguuc ugguugcac                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  38
ugauuuguuc ugguugcac                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  39
ngauuuguuc ugguugcac                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  40
ngauuuguuc ugguugcan                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  41
guauuuguac aggucaaag                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  42
uuauuuguac aggucaaag                                                    19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  43
nuauuuguac aggucaaag                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  44
nuauuuguac aggucaaan                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  45
cgaucuucca guccuucca                                                    19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  46
ugaucuucca guccuucca                                                    19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  47
ngaucuucca guccuucca                                                    19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  48
ngaucuucca guccuuccn                                                    19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  49
ccgaucuucc aguccuucc                                                    19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  50
ucgaucuucc aguccuucc                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  51
ncgaucuucc aguccuucc                                                    19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  52
ncgaucuucc aguccuucn                                                    19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  53
ugaagucauu cugcucugc                                                    19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  54
ngaagucauu cugcucugc                                                    19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  55
ngaagucauu cugcucugn                                                    19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  56
auagaagaug uaggcacag                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  57
uuagaagaug uaggcacag                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = any nucleotide

<400>  58
nuagaagaug uaggcacag                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  59
nuagaagaug uaggcacan                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  60
ugugcaacca gaacaaaua                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  61
ugugcaacca gaacaaauu                                                    19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  62
ugugcaacca gaacaaauc                                                    19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  63
ugugcaacca gaacaaaun                                                    19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  64
ngugcaacca gaacaaaun                                                    19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  65
agagcagaau gacuucauu                                                    19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  66
agagcagaau gacuucaua                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  67
agagcagaau gacuucaun                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  68
ngagcagaau gacuucaun                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  69
cuaccagaca uacucauca                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  70
cuaccagaca uacucaucn                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  71
nuaccagaca uacucaucn                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  72
ucuaccagac auacucauc                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  73
ucuaccagac auacucaua                                                    19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  74
ucuaccagac auacucaun                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  75
ncuaccagac auacucaun                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  76
gugcaaccag aacaaaucg                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  77
gugcaaccag aacaaauca                                                    19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  78
gugcaaccag aacaaaucn                                                    19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  79
nugcaaccag aacaaaucn                                                    19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  80
cuuugaccug uacaaauac                                                    19


<210>  81
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  81
cuuugaccug uacaaauaa                                                    19


<210>  82
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  82
cuuugaccug uacaaauan                                                    19


<210>  83
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  83
nuuugaccug uacaaauan                                                    19


<210>  84
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  84
uggaaggacu ggaagaucg                                                    19


<210>  85
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  85
uggaaggacu ggaagauca                                                    19


<210>  86
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  86
uggaaggacu ggaagaucn                                                    19


<210>  87
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  87
nggaaggacu ggaagaucn                                                    19


<210>  88
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  88
ggaaggacug gaagaucgg                                                    19


<210>  89
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  89
ggaaggacug gaagaucga                                                    19


<210>  90
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  90
ggaaggacug gaagaucgn                                                    19


<210>  91
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  91
ngaaggacug gaagaucgn                                                    19


<210>  92
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  92
gcagagcaga augacuuca                                                    19


<210>  93
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  93
gcagagcaga augacuucn                                                    19


<210>  94
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  94
ncagagcaga augacuucn                                                    19


<210>  95
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  95
cugugccuac aucuucuau                                                    19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  96
cugugccuac aucuucuaa                                                    19


<210>  97
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = any nucleotide

<400>  97
cugugccuac aucuucuan                                                    19


<210>  98
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>  
<221>  modified_base
<222>  1, 19
<223>  n = any nucleotide

<400>  98
nugugccuac aucuucuan                                                    19


<210>  99
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  99
uauuuguucu gguugcacag cug                                               23


<210>  100
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  100
uauuuguucu gguugcacag cug                                               23


<210>  101
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  101
uauuuguucu gguugcacag c                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  102
uauuuguucu gguugcacau u                                                 21


<210>  103
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  103
uauuuguucu gguugcacag c                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  104
aauuuguucu gguugcacag c                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  105
uaugaaguca uucugcucug c                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  106
ugaugaguau gucugguaga a                                                 21


<210>  107
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  107
ugauuuguuc ugguugcaca g                                                 21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  108
uaugaguaug ucugguagaa g                                                 21


<210>  109
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  109
uuauuuguac aggucaaaga g                                                 21


<210>  110
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  110
uaugaaguca uucugcucug c                                                 21


<210>  111
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  111
ugaugaguau gucugguaga a                                                 21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  112
ugauuuguuc ugguugcaca g                                                 21


<210>  113
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  113
uaugaguaug ucugguagaa g                                                 21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  114
uuauuuguac aggucaaaga g                                                 21


<210>  115
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  115
uaugaaguca uucugcucuu u                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  116
ugaugaguau gucugguagu u                                                 21


<210>  117
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  117
ugauuuguuc ugguugcacu u                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  118
uaugaguaug ucugguagau u                                                 21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  119
uuauuuguac aggucaaagu u                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  120
uauuuguucu gguugcacag c                                                 21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  121
uauuuguucu gguugcacag c                                                21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  122
uauuuguucu gguugcacag c                                                21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  123
uauuuguucu gguugcacag c                                                21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  124
uauuuguucu gguugcacag c                                                21


<210>  125
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  125
uauuuguucu gguugcacag c                                                21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  126
ugaucuucca guccuuccag u                                                 21


<210>  127
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  127
ucgaucuucc aguccuucca g                                                 21


<210>  128
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  128
ugaagucauu cugcucugcg c                                                 21


<210>  129
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  129
auagaagaug uaggcacagc c                                                 21


<210>  130
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  130
uaucgugaca gagggagacu c                                                 21


<210>  131
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  131
uugaccaucg ugacagaggg a                                                 21


<210>  132
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  132
uauuuguucu gguugcacag c                                                 21


<210>  133
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  133
uauuuguucu gguugcacag cu                                                22


<210>  134
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  134
uauuuguucu gguugcacag cuu                                               23


<210>  135
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  135
uauuuguucu gguugcacag g                                                21


<210>  136
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  136
uauuuguucu gguugcacag u                                                21


<210>  137
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  137
uauuuguucu gguugcacag   g                                              21


<210>  138
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  138
uauuuguucu gguugcacgg g                                                21


<210>  139
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  139
uauuuguucu gguugcacgg u                                                 21


<210>  140
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  140
uauuuguucu gguugcaccg u                                                 21


<210>  141
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  141
uauuuguucu gguugcacag u                                                 21


<210>  142
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  142
uauuuguucu gguugcacag a                                                 21


<210>  143
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  143
uauuuguucu gguugcacag g                                                 21


<210>  144
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  144
uauuuguuc ugguugcacag g                                                21


<210>  145
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  145
uauuuguucu gguugcacag g                                                 21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  146
uauuuguucu gguugcacag g                                                 21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  147
uauuuguucu gguugcacag g                                                 21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  148
nauuuguucu gguugcacag g                                               21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  149
uauuuguucu gguugcacag u                                                 21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  150
uauuuguucu gguugcacag u                                                 21


<210>  151
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  151
tauuuguucu gguugcacag c                                                 21


<210>  152
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  152
agaagucauu cugcucugcu u                                                 21


<210>  153
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  153
gcugugcaac cagaacaaau a                                                 21


<210>  154
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  154
gcugugcaac cagaacaaau a                                                 21


<210>  155
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  155
gcugugcaac cagaacaaau u                                                 21


<210>  156
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  156
gcugugcaac cagaacaaau a                                                 21


<210>  157
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  157
gcagagcaga augacuucau a                                                 21


<210>  158
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  158
uucuaccaga cauacucauc a                                                 21


<210>  159
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  159
cugugcaacc agaacaaauc a                                                 21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  160
cuucuaccag acauacucau a                                                 21


<210>  161
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  161
cucuuugacc uguacaaaua a                                                 21


<210>  162
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  162
agagcagaau gacuucauau u                                                 21


<210>  163
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  163
cuaccagaca uacucaucau u                                                 21


<210>  164
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  164
gugcaaccag aacaaaucau u                                                 21


<210>  165
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  165
ucuaccagac auacucauau u                                                 21


<210>  166
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  166
cuuugaccug uacaaauaau u                                                 21


<210>  167
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  167
gcugugcaac cagaacaaau a                                                 21


<210>  168
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  168
gcugugcaac cagaacaaau a                                                 21


<210>  169
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  169
gcugugcaac cagaacaaau a                                                 21


<210>  170
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  170
acuggaagga cuggaagauc a                                                 21


<210>  171
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  171
cuggaaggac uggaagaucg a                                                 21


<210>  172
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  172
gcgcagagca gaaugacuuc a                                                 21


<210>  173
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  173
ggcugugccu acaucuucua u                                                 21


<210>  174
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  174
gagucucccu cugucacgau a                                                 21


<210>  175
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  175
ucccucuguc acgaugguca a                                                 21


<210>  176
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  176
gcugugcaac cagaacaaau a                                                 21


<210>  177
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  177
ccugugcaac cagaacaaau a                                                 21


<210>  178
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  178
ccugugcaac cagaacaaau a                                                 21


<210>  179
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  179
ccugugcaac cagaacaaau a                                                 21


<210>  180
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  13
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  180
ccugugcaac canaacaaau a                                                 21


<210>  181
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  181
ccugugcaac cagaacanau a                                                 21


<210>  182
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  182
acugugcaac cagaacaaau a                                                 21


<210>  183
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  183
ccugugcaac cagaacaaau a                                                 21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  13
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  184
ccugugcaac canaacaaau a                                                 21


<210>  185
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  185
ccugugcaac uagaacaaau a                                                 21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  186
cccgugcaac cagaacaaau a                                                 21


<210>  187
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  187
accgugcaac cagaacaaau a                                                 21


<210>  188
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  188
ccugugcaac cagaacaaau a                                                 21


<210>  189
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  189
ccugugcaac cagaacaaau a                                                 21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  190
gcugugcaac cagaacaaau a                                                 21


<210>  191
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  191
ccugugcaac cagaacaaau a                                                 21


<210>  192
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  192
ccugugcaac cagaacaaau a                                                 21


<210>  193
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  193
ccugugcaac cagaacaaau a                                                 21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  194
ccugugcaac cagaacaaau a                                                 21


<210>  195
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  195
ccugugcaac cagaacaaau a                                                 21


<210>  196
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  196
acggugcaac cagaacaaau a                                                 21


<210>  197
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  197
acugugcaac cagaacaaau a                                                 21


<210>  198
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  198
acugugcaac cagaacaanu a                                                21


<210>  199
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  199
acugugcaac cagaacanau a                                                21


<210>  200
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  17
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  200
acugugcaac cagaacnaau a                                                21


<210>  201
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  201
ucugugcaac cagaacaaau a                                                 21


<210>  202
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  202
ccugugcaac cagaacanau a                                              21


<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  203
ccugugcaac cagaacanau a                                              21


<210>  204
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  204
ccugugcaac cagaacaanu a                                              21


<210>  205
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  17
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  205
ccugugcaac cagaacnaau a                                              21


<210>  206
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  206
ccugugcaac cagaacaaau a                                                 21


<210>  207
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  207
ccugugcaac cagaacaaau a                                                 21


<210>  208
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  208
ccugugcaac cagaacaaau a                                                 21


<210>  209
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  209
ccugugcaac cagaacaaau c                                                 21


<210>  210
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  210
acugugcaac cagaacaaau a                                                 21


<210>  211
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  211
acugugcaac cagaacaaau a                                                 21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  212
acugugcaac cagaacanau a                                                21


<210>  213
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  213
ccugugcaac cagaacaaau a                                                 21


<210>  214
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  214
ccugugcaac cagaacaaau a                                                 21


<210>  215
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  215
gcugugcaac cagaacaaau a                                                 21


<210>  216
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  216
ccugugcaac cagaacaaau a                                                 21


<210>  217
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  217
ccugugcaac cagaacaaau a                                                 21


<210>  218
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  218
acuggaagga cuggaagauc a                                                 21


<210>  219
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  219
cugugcaacc agaacaaauc a                                                 21


<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  220
cugugcaacc agaacaaauc a                                                 21


<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  221
gcagagcaga augacuucuu u                                                 21


<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  222
gcagagcaga augacuucuu u                                                 21


<210>  223
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  223
ccugugcaac cagaacaaau a                                                 21

<210>  224
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  224
uauuuguucu gguugcacag cug                                               23


<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  225
uauuuguucu gguugcacag c                                                 21


<210>  226
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  226
uauuuguucu gguugcacau u                                                 21


<210>  227
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  227
aauuuguucu gguugcacag c                                                 21


<210>  228
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  228
uaugaaguca uucugcucug c                                                 21


<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  229
ugaugaguau gucugguaga a                                                 21


<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  230
ugauuuguuc ugguugcaca g                                                 21


<210>  231
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  231
uaugaguaug ucugguagaa g                                                 21


<210>  232
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  232
uuauuuguac aggucaaaga g                                                 21


<210>  233
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  233
uaugaaguca uucugcucuu u                                                 21


<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  234
ugaugaguau gucugguagu u                                                 21


<210>  235
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  235
ugauuuguuc ugguugcacu u                                                 21


<210>  236
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  236
uaugaguaug ucugguagau u                                                 21


<210>  237
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  237
uuauuuguac aggucaaagu u                                                 21


<210>  238
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  238
ugaucuucca guccuuccag u                                                 21


<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  239
ucgaucuucc aguccuucca g                                                 21


<210>  240
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  240
ugaagucauu cugcucugcg c                                                 21


<210>  241
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  241
auagaagaug uaggcacagc c                                                 21


<210>  242
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  242
uaucgugaca gagggagacu c                                                 21


<210>  243
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  243
uugaccaucg ugacagaggg a                                                 21


<210>  244
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  244
uauuuguucu gguugcacag cu                                                22


<210>  245
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  245
uauuuguucu gguugcacag cuu                                               23


<210>  246
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  246
uauuuguucu gguugcacag g                                                 21


<210>  247
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  247
uauuuguucu gguugcacag u                                                 21


<210>  248
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  248
uauuuguucu gguugcacgg g                                                 21


<210>  249
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  249
uauuuguucu gguugcacgg u                                                 21


<210>  250
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  250
uauuuguucu gguugcaccg u                                                 21


<210>  251
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  251
uauuuguucu gguugcacag a                                                 21


<210>  252
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<220>  
<221>  modified_base
<222>  1
<223>  n = inosine (hypoxanthine)

<400>  252
nauuuguucu gguugcacag g                                                21


<210>  253
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  253
tauuuguucu gguugcacag c                                                 21


<210>  254
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  254
agaagucauu cugcucugcu u                                                 21


<210>  255
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  255
gcugugcaac cagaacaaau a                                                 21


<210>  256
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  256
gcugugcaac cagaacaaau u                                                 21


<210>  257
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  257
gcagagcaga augacuucau a                                                 21


<210>  258
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  258
uucuaccaga cauacucauc a                                                 21


<210>  259
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  259
cugugcaacc agaacaaauc a                                                 21


<210>  260
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  260
cuucuaccag acauacucau a                                                 21


<210>  261
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  261
cucuuugacc uguacaaaua a                                                 21


<210>  262
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  262
agagcagaau gacuucauau u                                                 21


<210>  263
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  263
cuaccagaca uacucaucau u                                                 21


<210>  264
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  264
gugcaaccag aacaaaucau u                                                 21


<210>  265
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  265
ucuaccagac auacucauau u                                                 21


<210>  266
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  266
cuuugaccug uacaaauaau u                                                 21


<210>  267
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  267
acuggaagga cuggaagauc a                                                 21


<210>  268
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  268
cuggaaggac uggaagaucg a                                                 21


<210>  269
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  269
gcgcagagca gaaugacuuc a                                                 21


<210>  270
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  270
ggcugugccu acaucuucua u                                                 21


<210>  271
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  271
gagucucccu cugucacgau a                                                 21


<210>  272
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  272
ucccucuguc acgaugguca a                                                 21


<210>  273
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  273
ccugugcaac cagaacaaau a                                                 21


<210>  274
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  13
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  274
ccugugcaac canaacaaau a                                                 21


<210>  275
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  275
ccugugcaac cagaacanau a                                                 21


<210>  276
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  276
acugugcaac cagaacaaau a                                                 21


<210>  277
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  277
ccugugcaac uagaacaaau a                                                 21


<210>  278
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  278
cccgugcaac cagaacaaau a                                                 21


<210>  279
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  279
accgugcaac cagaacaaau a                                                 21


<210>  280
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  280
acggugcaac cagaacaaau a                                                 21


<210>  281
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  281
acugugcaac cagaacaanu a                                                 21


<210>  282
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  282
acugugcaac cagaacanau a                                                 21


<210>  283
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  17
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  283
acugugcaac cagaacnaau a                                                 21


<210>  284
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  284
ucugugcaac cagaacaaau a                                                21


<210>  285
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  285
ccugugcaac cagaacanaua                                                21


<210>  286
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  286
ccugugcaac cagaacaanu a                                             21


<210>  287
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>  
<221>  modified_base
<222>  17
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  287
ccugugcaac cagaacnaau a                                            21


<210>  288
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  288
ccugugcaac cagaacaaau c                                             21


<210>  289
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  289
gcagagcaga augacuucuu u                                             21


<210>  290
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetrapeptide linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Citrulline

<400>  290
Phe Xaa Phe Pro 
1               


<210>  291
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ND-9201 modified antisense strand sequence

<400>  291
gauuuguucu gguugcacat t                                             21


<210>  292
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ND-9201 modified antisense strand sequence

<400>  292
ugugcaacca gaacaaauct t                                             21


<210>  293
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  293
cugugcaacc agaacaaauc a                                             21


<210>  294
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  294
gcagagcaga augacuucuu u                                              21


<210>  295
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  295
aaugugcaac cagaacaaau a                                             21


<210>  296
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  296
aaugugcaac cagaacaaau a                                             21
