                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  ROR1 CAR T-CELLS

<130>  P532708PCTJW

<150>  GB 1710836.6
<151>  2017-07-05

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  2
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  2

Gly Gly Gly Gly Ser 
1               5   


<210>  3
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Leu 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised light chain variable region

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised light chain variable region

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised light chain variable region

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised light chain variable region

<400>  7

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised light chain variable region

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asp Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Arg Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain variable region

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain variable region

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain variable region

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain variable region

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain variable region

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Glu His 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Arg Tyr Asn Leu Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  26
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser 
            20                  25      


<210>  16
<211>  6
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Gln Asn Ile Asp Arg Tyr 
1               5       


<210>  17
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Leu 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  3
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Asn Thr Asn 
1           


<210>  19
<211>  36
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Lys Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Ala 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  20
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Leu Gln Tyr Asn Ser Leu Pro Leu Thr 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  22
<211>  25
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  23
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Gly Phe Ile Phe Ser Glu His Asn 
1               5               


<210>  24
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  25
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Ile Ser Asp Asp Gly Arg Asn Thr 
1               5               


<210>  26
<211>  38
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Glu Asn 
1               5                   10                  15      


Ala Arg Ser Thr Leu Tyr Leu Gln Leu Asp Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  27
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  27

Ala Ser His Arg Tyr Asn Leu Phe Asp Ser 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  30
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  31
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  33
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  35
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Thr Ser 
        35                  40  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain CDR3

<400>  36

Thr Ser His Arg Tyr Asn Leu Phe Asp Ser 
1               5                   10  


<210>  37
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  37

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  39
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  39

Lys Leu Gln Thr Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  41
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  42
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Thr 
    


<210>  43
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  43

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Lys 
        35                  40  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain CDR3

<400>  44

Ala Lys His Arg Tyr Asn Leu Phe Asp Ser 
1               5                   10  


<210>  45
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  45

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  47

Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  48
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  48

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised heavy chain CDR3

<400>  49

Ala Arg His Arg Tyr Asn Leu Phe Asp Ser 
1               5                   10  


<210>  50
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  51
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser 
1               5                   10                  15      


Thr 
    


<210>  52
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  52

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  53
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  54
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  54

Lys Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  55
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  56
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  56

Tyr Tyr Arg Asp Ser Met Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Leu Tyr Tyr Cys Ala Lys 
        35                  40  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain CDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Ala or Thr

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Ser, Lys or Arg

<400>  57

Xaa Xaa His Arg Tyr Asn Leu Phe Asp Ser 
1               5                   10  


<210>  58
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  58

Lys Ala Ser Gln Asn Ile Asp Arg Tyr Leu Asn 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Asn Thr Asn Lys Leu Gln Thr 
1               5           


<210>  60
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  60

Glu His Asn Met Ala 
1               5   


<210>  61
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  61

Thr Ile Ser Asp Asp Gly Arg Asn Thr Tyr Tyr Arg Asp Ser Met Arg 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  62

His Arg Tyr Asn Leu Phe Asp Ser 
1               5               


