﻿               SEQUENCE LISTING

<110> GENETHON
      UNIVERSITE D'EVRY-VAL-D'ESSONNE
      INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

<120> NOVEL POLYNUCLEOTIDES ENCODING A HUMAN FKRP PROTEIN

<130> G143-B-49229 PCT

<150> EP17305894.2
<151> 2017-07-07

<160> 21

<170> BiSSAP 1.3.2

<210> 1
<211> 495
<212> PRT
<213> Homo sapiens

<223> "FKRP"

<220> 
<223> FKRP

<400> 1
Met Arg Leu Thr Arg Cys Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      
Asn Leu Leu Val Leu Phe Tyr Val Ser Trp Leu Gln His Gln Pro Arg 
            20                  25                  30          
Asn Ser Arg Ala Arg Gly Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg 
        35                  40                  45              
Val Thr Val Leu Val Arg Glu Phe Glu Ala Phe Asp Asn Ala Val Pro 
    50                  55                  60                  
Glu Leu Val Asp Ser Phe Leu Gln Gln Asp Pro Ala Gln Pro Val Val 
65                  70                  75                  80  
Val Ala Ala Asp Thr Leu Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile 
                85                  90                  95      
Pro Asn Val Arg Leu Ala Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala 
            100                 105                 110         
Ala Ala Ser Arg Pro Glu Thr Tyr Val Ala Thr Glu Phe Val Ala Leu 
        115                 120                 125             
Val Pro Asp Gly Ala Arg Ala Glu Ala Pro Gly Leu Leu Glu Arg Met 
    130                 135                 140                 
Val Glu Ala Leu Arg Ala Gly Ser Ala Arg Leu Val Ala Ala Pro Val 
145                 150                 155                 160 
Ala Thr Ala Asn Pro Ala Arg Cys Leu Ala Leu Asn Val Ser Leu Arg 
                165                 170                 175     
Glu Trp Thr Ala Arg Tyr Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp 
            180                 185                 190         
Ala Leu Asp Gly Asp Ala Val Val Leu Leu Arg Ala Arg Asp Leu Phe 
        195                 200                 205             
Asn Leu Ser Ala Pro Leu Ala Arg Pro Val Gly Thr Ser Leu Phe Leu 
    210                 215                 220                 
Gln Thr Ala Leu Arg Gly Trp Ala Val Gln Leu Leu Asp Leu Thr Phe 
225                 230                 235                 240 
Ala Ala Ala Arg Gln Pro Pro Leu Ala Thr Ala His Ala Arg Trp Lys 
                245                 250                 255     
Ala Glu Arg Glu Gly Arg Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu 
            260                 265                 270         
Gly Ile Arg Leu Val Ser Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly 
        275                 280                 285             
Cys Asn Lys Glu Thr Thr Arg Cys Phe Gly Thr Val Val Gly Asp Thr 
    290                 295                 300                 
Pro Ala Tyr Leu Tyr Glu Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg 
305                 310                 315                 320 
Ala Leu Arg Glu Thr Ala Arg Tyr Val Val Gly Val Leu Glu Ala Ala 
                325                 330                 335     
Gly Val Arg Tyr Trp Leu Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg 
            340                 345                 350         
His Gly Asp Ile Ile Pro Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr 
        355                 360                 365             
Leu Glu Asp Val Gly Asn Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly 
    370                 375                 380                 
Ser Val Val Asp Glu Arg Gly Phe Val Trp Glu Lys Ala Val Glu Gly 
385                 390                 395                 400 
Asp Phe Phe Arg Val Gln Tyr Ser Glu Ser Asn His Leu His Val Asp 
                405                 410                 415     
Leu Trp Pro Phe Tyr Pro Arg Asn Gly Val Met Thr Lys Asp Thr Trp 
            420                 425                 430         
Leu Asp His Arg Gln Asp Val Glu Phe Pro Glu His Phe Leu Gln Pro 
        435                 440                 445             
Leu Val Pro Leu Pro Phe Ala Gly Phe Val Ala Gln Ala Pro Asn Asn 
    450                 455                 460                 
Tyr Arg Arg Phe Leu Glu Leu Lys Phe Gly Pro Gly Val Ile Glu Asn 
465                 470                 475                 480 
Pro Gln Tyr Pro Asn Pro Ala Leu Leu Ser Leu Thr Gly Ser Gly 
                485                 490                 495 

<210> 2
<211> 1488
<212> DNA
<213> Homo sapiens

<223> "FKRP wt"

<220> 
<223> FKRP wt

<400> 2
atgcggctca cccgctgcca ggctgccctg gcggccgcca tcaccctcaa ccttctggtc      60

ctcttctatg tctcgtggct gcagcaccag cctaggaatt cccgggcccg ggggccccgt     120

cgtgcctctg ctgccggccc ccgtgtcacc gtcctggtgc gggagttcga ggcatttgac     180

aacgcggtgc ccgagctggt agactccttc ctgcagcaag acccagccca gcccgtggtg     240

gtggcagccg acacgctccc ctacccgccc ctggccctgc cccgcatccc caacgtgcgt     300

ctggcgctgc tccagcccgc cctggaccgg ccagccgcag cctcgcgccc ggagacctac     360

gtggccaccg agtttgtggc cctagtacct gatggggcgc gggctgaggc acctggcctg     420

ctggagcgca tggtggaggc gctccgcgca ggaagcgcac gtctggtggc cgccccggtt     480

gccacggcca accctgccag gtgcctggcc ctgaacgtca gcctgcgaga gtggaccgcc     540

cgctatggcg cagcccccgc cgcgccccgc tgcgacgccc tggacggaga tgctgtggtg     600

ctcctgcgcg cccgcgacct cttcaacctc tcggcgcccc tggcccggcc ggtgggcacc     660

agcctctttc tgcagaccgc ccttcgcggc tgggcggtgc agctgctgga cttgaccttc     720

gccgcggcgc gccagccccc gctggccacg gcccacgcgc gctggaaggc tgagcgcgag     780

ggacgcgctc ggcgggcggc gctgctccgc gcgctgggca tccgcctagt gagctgggaa     840

ggcgggcggc tggagtggtt cggctgcaac aaggagacca cgcgctgctt cggaaccgtg     900

gtgggcgaca cgcccgccta cctctacgag gagcgctgga cgcccccctg ctgcctgcgc     960

gcgctgcgcg agaccgcccg ctatgtggtg ggcgtgctgg aggctgcggg cgtgcgctac    1020

tggctcgagg gcggctcact gctgggggcc gcccgccacg gggacatcat cccatgggac    1080

tacgacgtgg acctgggcat ctacttggag gacgtgggca actgcgagca gctgcggggg    1140

gcagaggccg gctcggtggt ggatgagcgc ggcttcgtat gggagaaggc ggtcgagggc    1200

gactttttcc gcgtgcagta cagcgaaagc aaccacttgc acgtggacct gtggcccttc    1260

tacccccgca atggcgtcat gaccaaggac acgtggctgg accaccggca ggatgtggag    1320

tttcccgagc acttcctgca gccgctggtg cccctgccct ttgccggctt cgtggcgcag    1380

gcgcctaaca actaccgccg cttcctggag ctcaagttcg ggcccggggt catcgagaac    1440

ccccagtacc ccaacccggc actgctgagt ctgacgggaa gcggctga                 1488


<210> 3
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPTmin"

<220> 
<223> FKRP-OPTmin

<400> 3
atgcggctca cccgctgcca ggctgccctg gcggccgcca tcaccctcaa ccttctggtc      60

ctcttctatg tctcgtggct gcagcaccag cctaggaatt cccgggcccg ggggccccgt     120

cgtgcctctg ctgccggccc ccgtgtcacc gtcctggtgc gggagttcga ggcatttgac     180

aacgcggtgc ccgagctggt agactccttc ctgcagcaag acccagccca gcccgtggtg     240

gtggcagccg acacgctccc ctacccgccc ctggccctgc cccgcatccc caacgtgcgt     300

ctggcgctgc tccagcccgc cctggaccgg ccagccgcag cctcgcgccc ggagacctac     360

gtggccaccg agtttgtggc cctagtacct gatggggcgc gggctgaggc acctggcctg     420

ctggagcgga tggtggaggc gctccgcgca ggaagcgcac gtctggtggc cgccccggtt     480

gccacggcca accctgccag gtgcctggcc ctgaacgtca gcctgcgaga gtggaccgcc     540

cgctacggcg cagcccccgc cgcgccccgc tgcgacgccc tggacggaga tgctgtggtg     600

ctcctgcgcg cccgcgacct cttcaacctc tcggcgcccc tggcccggcc ggtgggcacc     660

agcctctttc tgcagaccgc ccttcgcggc tgggcggtgc agctgctgga cttgaccttc     720

gccgcggcgc gccagccccc gctggccacg gcccacgcgc gctggaaggc tgagcgcgag     780

ggacgcgctc ggcgggcggc gctgctccgc gcgctgggaa tccgcctagt gagctgggaa     840

ggcgggcggc tggagtggtt cggctgcaac aaggagacca cgcgctgctt cggaaccgtg     900

gtgggcgaca cgcccgccta cctctacgag gagcgctgga cgcccccctg ctgcctgcgc     960

gcgctgcgcg agaccgcccg ctatgtggtg ggcgtgctgg aggctgcggg cgtgcgctac    1020

tggctcgagg gcggctcact gctgggggcc gcccgccacg gggacatcat cccatgggac    1080

tacgacgtgg acctgggcat ctacttggag gacgtgggca actgcgagca gctgcggggg    1140

gcagaggccg gctcggtggt ggatgagcgc ggcttcgtat gggagaaggc ggtcgagggc    1200

gactttttcc gcgtgcagta cagcgaaagc aaccacttgc acgtggacct gtggcccttc    1260

tacccccgca atggcgtcat gaccaaggac acgtggctgg accaccggca ggatgtggag    1320

tttcccgagc acttcctgca gccgctggtg cccctgccct ttgccggctt cgtggcgcag    1380

gcgcctaaca actaccgccg cttcctggag ctcaagttcg ggcccggggt gatcgagaac    1440

ccccagtacc ccaacccggc actgctgagt ctgacgggaa gcggctga                 1488


<210> 4
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPTcomp"

<220> 
<223> FKRP-OPTcomp

<400> 4
atgagactga ccaggtgcca ggctgccctg gctgctgcca tcaccctgaa cctgctggtg      60

ctgttctatg tgagctggct gcagcaccag cccaggaaca gcagggccag gggccccagg     120

agggcctctg ctgctggccc cagggtgaca gtgctggtga gggagtttga ggcctttgac     180

aatgctgtgc ctgagctggt ggacagcttc ctgcagcagg accctgccca gcctgtggtg     240

gtggctgctg ataccctgcc ctaccccccc ctggccctgc ccaggatccc caatgtgagg     300

ctggccctgc tgcagcctgc cctggacagg cctgctgctg ccagcaggcc tgagacctat     360

gtggccacag agtttgtggc cctggtgcct gatggggcca gggctgaggc ccctggcctg     420

ctggagagga tggtggaggc cctgagggct ggctctgcca ggctggtggc tgcccctgtg     480

gccacagcca accctgccag gtgcctggcc ctgaatgtga gcctgagaga gtggacagcc     540

aggtatgggg ctgcccctgc tgcccccagg tgtgatgccc tggatggaga tgctgtggtg     600

ctgctgaggg ccagggacct gttcaacctg tctgcccccc tggccaggcc tgtggggacc     660

agcctgtttc tgcagacagc cctgaggggc tgggctgtgc agctgctgga cctgaccttt     720

gctgctgcca ggcagccccc cctggctaca gcccacgcca ggtggaaggc tgagagggag     780

ggcagggcca ggagggctgc cctgctgagg gccctgggga tcaggctggt gagctgggag     840

gggggcaggc tggagtggtt tggctgcaac aaggagacaa ccaggtgctt tgggacagtg     900

gtgggggata cccctgccta cctgtatgag gagaggtgga cccccccctg ctgcctgagg     960

gccctgaggg agacagccag gtatgtggtg ggggtgctgg aggctgctgg ggtgaggtac    1020

tggctggagg ggggcagcct gctgggggct gccaggcacg gggacattat cccctgggac    1080

tatgatgtgg acctgggcat ctacctggag gatgtgggca actgtgagca gctgaggggg    1140

gctgaggctg gctctgtggt ggatgagagg ggctttgtgt gggagaaggc tgtggagggg    1200

gactttttca gggtgcagta ctctgagagc aaccacctgc acgtggacct gtggcccttc    1260

taccccagga atggggtgat gaccaaggac acctggctgg accacaggca ggatgtggag    1320

ttccctgagc acttcctgca gcccctggtg cccctgccct ttgctggctt tgtggcccag    1380

gcccccaaca actacaggag gttcctggag ctgaagtttg gccctggggt gattgagaac    1440

ccccagtacc ccaaccctgc cctgctgagc ctgacaggct ctggctga                 1488


<210> 5
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPT-07"

<220> 
<223> FKRP-OPT-07

<400> 5
atgcggctca cccgctgcca ggctgccctg gctgccgcca tcaccctcaa ccttctggtc      60

ctcttctatg tcagctggct gcagcaccag cctaggaatt cccgggcccg ggggcccagg     120

agggcctctg ctgccggccc cagggtcacc gtcctggtgc gggagttcga ggcatttgac     180

aacgctgtgc ccgagctggt agactccttc ctgcagcaag acccagccca gcccgtggtg     240

gtggcagccg acaccctccc ctaccccccc ctggccctgc cccgcatccc caacgtgagg     300

ctggccctgc tccagcccgc cctggaccgg ccagccgcag ccagccgccc tgagacctac     360

gtggccaccg agtttgtggc cctggtacct gatggggccc gggctgaggc acctggcctg     420

ctggagcgga tggtggaggc cctccgcgca ggaagcgcaa ggctggtggc cgcccctgtt     480

gccacagcca accctgccag gtgcctggcc ctgaacgtca gcctgcgaga gtggaccgcc     540

cgctacggcg cagcccccgc cgccccccgc tgcgacgccc tggacggaga tgctgtggtg     600

ctcctgcgcg cccgcgacct cttcaacctc tctgcccccc tggcccggcc tgtgggcacc     660

agcctctttc tgcagaccgc ccttcgcggc tgggctgtgc agctgctgga cttgaccttc     720

gccgctgccc gccagccccc cctggccaca gcccacgccc gctggaaggc tgagcgcgag     780

ggacgcgctc ggcgggctgc cctgctccgc gccctgggaa tccgcctggt gagctgggaa     840

ggcgggcggc tggagtggtt cggctgcaac aaggagacca cccgctgctt cggaaccgtg     900

gtgggcgaca cccccgccta cctctacgag gagcgctgga cccccccctg ctgcctgcgc     960

gccctgcgcg agaccgcccg ctatgtggtg ggcgtgctgg aggctgctgg cgtgcgctac    1020

tggctcgagg gcggctcact gctgggggcc gcccgccacg gggacatcat cccatgggac    1080

tacgacgtgg acctgggcat ctacttggag gacgtgggca actgcgagca gctgcggggg    1140

gcagaggccg gctctgtggt ggatgagcgc ggcttcgtat gggagaaggc tgtcgagggc    1200

gactttttcc gcgtgcagta cagcgaaagc aaccacttgc acgtggacct gtggcccttc    1260

tacccccgca atggcgtcat gaccaaggac acctggctgg accaccggca ggatgtggag    1320

tttcccgagc acttcctgca gcccctggtg cccctgccct ttgccggctt cgtggcccag    1380

gcccctaaca actaccgccg cttcctggag ctcaagttcg ggcccggggt gatcgagaac    1440

ccccagtacc ccaaccctgc actgctgagt ctgaccggaa gcggctga                 1488


<210> 6
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPT-08"

<220> 
<223> FKRP-OPT-08

<400> 6
atgcggctca cccgctgcca ggctgccctg gctgctgcca tcaccctcaa ccttctggtc      60

ctcttctatg tcagctggct gcagcaccag cctaggaatt cccgggcccg ggggcccagg     120

agggcctctg ctgctggccc cagggtcacc gtcctggtgc gggagttcga ggcatttgac     180

aacgctgtgc ccgagctggt agactccttc ctgcagcaag acccagccca gcccgtggtg     240

gtggcagctg acaccctccc ctaccccccc ctggccctgc cccgcatccc caacgtgagg     300

ctggccctgc tccagcccgc cctggaccgg ccagctgcag ccagccgccc tgagacctac     360

gtggccaccg agtttgtggc cctggtacct gatggggccc gggctgaggc acctggcctg     420

ctggagcgga tggtggaggc cctcagggca ggaagcgcaa ggctggtggc tgcccctgtt     480

gccacagcca accctgccag gtgcctggcc ctgaacgtca gcctgcgaga gtggaccgcc     540

cgctacgggg cagcccccgc tgccccccgc tgcgacgccc tggacggaga tgctgtggtg     600

ctcctgaggg ccagggacct cttcaacctc tctgcccccc tggcccggcc tgtgggcacc     660

agcctctttc tgcagaccgc ccttaggggc tgggctgtgc agctgctgga cttgaccttc     720

gctgctgccc gccagccccc cctggccaca gcccacgccc gctggaaggc tgagagggag     780

ggaagggctc ggcgggctgc cctgctcagg gccctgggaa tccgcctggt gagctgggaa     840

ggggggcggc tggagtggtt cggctgcaac aaggagacca cccgctgctt cggaaccgtg     900

gtgggggaca cccccgccta cctctacgag gagcgctgga cccccccctg ctgcctgagg     960

gccctgaggg agaccgcccg ctatgtggtg ggggtgctgg aggctgctgg ggtgcgctac    1020

tggctcgagg ggggctcact gctgggggct gcccgccacg gggacatcat cccatgggac    1080

tacgacgtgg acctgggcat ctacttggag gacgtgggca actgcgagca gctgcggggg    1140

gcagaggctg gctctgtggt ggatgagagg ggcttcgtat gggagaaggc tgtggagggg    1200

gactttttca gggtgcagta cagcgaaagc aaccacttgc acgtggacct gtggcccttc    1260

tacccccgca atggggtcat gaccaaggac acctggctgg accaccggca ggatgtggag    1320

tttcccgagc acttcctgca gcccctggtg cccctgccct ttgctggctt cgtggcccag    1380

gcccctaaca actaccgccg cttcctggag ctcaagttcg ggcccggggt gatcgagaac    1440

ccccagtacc ccaaccctgc actgctgagt ctgaccggaa gcggctga                 1488


<210> 7
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPT-10"

<220> 
<223> FKRP-OPT-10

<400> 7
atgagactga caaggtgcca ggctgccctg gctgctgcca tcacactgaa cctgctggtg      60

ctgttttatg tgagctggct gcagcaccag cctaggaaca gcagggccag gggccctagg     120

agggcctctg ctgctggccc tagggtgaca gtgctggtga gggagtttga ggcctttgac     180

aatgctgtgc ctgagctggt ggacagcttt ctgcagcagg accctgccca gcctgtggtg     240

gtggctgctg atacactgcc ttaccctcct ctggccctgc ctaggatccc taatgtgagg     300

ctggccctgc tgcagcctgc cctggacagg cctgctgctg ccagcaggcc tgagacttat     360

gtggccacag agtttgtggc cctggtgcct gatggggcca gggctgaggc ccctggcctg     420

ctggagagga tggtggaggc cctgagggct ggctctgcca ggctggtggc tgcccctgtg     480

gccacagcca accctgccag gtgcctggcc ctgaatgtga gcctgagaga gtggacagcc     540

aggtatgggg ctgcccctgc tgcccctagg tgtgatgccc tggatggaga tgctgtggtg     600

ctgctgaggg ccagggacct gtttaacctg tctgcccctc tggccaggcc tgtggggaca     660

agcctgtttc tgcagacagc cctgaggggc tgggctgtgc agctgctgga cctgacattt     720

gctgctgcca ggcagcctcc tctggctaca gcccacgcca ggtggaaggc tgagagggag     780

ggcagggcca ggagggctgc cctgctgagg gccctgggga tcaggctggt gagctgggag     840

gggggcaggc tggagtggtt tggctgcaac aaggagacaa caaggtgctt tgggacagtg     900

gtgggggata cacctgccta cctgtatgag gagaggtgga cacctccttg ctgcctgagg     960

gccctgaggg agacagccag gtatgtggtg ggggtgctgg aggctgctgg ggtgaggtac    1020

tggctggagg ggggcagcct gctgggggct gccaggcacg gggacattat cccttgggac    1080

tatgatgtgg acctgggcat ctacctggag gatgtgggca actgtgagca gctgaggggg    1140

gctgaggctg gctctgtggt ggatgagagg ggctttgtgt gggagaaggc tgtggagggg    1200

gactttttta gggtgcagta ctctgagagc aaccacctgc acgtggacct gtggcctttt    1260

taccctagga atggggtgat gacaaaggac acatggctgg accacaggca ggatgtggag    1320

tttcctgagc actttctgca gcctctggtg cctctgcctt ttgctggctt tgtggcccag    1380

gcccctaaca actacaggag gtttctggag ctgaagtttg gccctggggt gattgagaac    1440

cctcagtacc ctaaccctgc cctgctgagc ctgacaggct ctggctga                 1488


<210> 8
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "FKRP-OPT-11"

<220> 
<223> FKRP-OPT-11

<400> 8
atgagactga caaggtgcca ggctgccctg gctgctgcca tcacactgaa cctgctggtg      60

ctgttttatg tgagctggct gcagcaccag cctagaaaca gcagagccag aggccctaga     120

agagcctctg ctgctggccc tagagtgaca gtgctggtga gagagtttga ggcctttgac     180

aatgctgtgc ctgagctggt ggacagcttt ctgcagcagg accctgccca gcctgtggtg     240

gtggctgctg atacactgcc ttaccctcct ctggccctgc ctagaatccc taatgtgaga     300

ctggccctgc tgcagcctgc cctggacaga cctgctgctg ccagcagacc tgagacttat     360

gtggccacag agtttgtggc cctggtgcct gatggggcca gagctgaggc ccctggcctg     420

ctggagagaa tggtggaggc cctgagagct ggctctgcca gactggtggc tgcccctgtg     480

gccacagcca accctgccag atgcctggcc ctgaatgtga gcctgagaga gtggacagcc     540

agatatgggg ctgcccctgc tgcccctaga tgtgatgccc tggatggaga tgctgtggtg     600

ctgctgagag ccagagacct gtttaacctg tctgcccctc tggccagacc tgtggggaca     660

agcctgtttc tgcagacagc cctgagaggc tgggctgtgc agctgctgga cctgacattt     720

gctgctgcca gacagcctcc tctggctaca gcccacgcca gatggaaggc tgagagagag     780

ggcagagcca gaagagctgc cctgctgaga gccctgggga tcaggctggt gagctgggag     840

gggggcagac tggagtggtt tggctgcaac aaggagacaa caagatgctt tgggacagtg     900

gtgggggata cacctgccta cctgtatgag gagaggtgga cacctccttg ctgcctgaga     960

gccctgagag agacagccag atatgtggtg ggggtgctgg aggctgctgg ggtgagatac    1020

tggctggagg ggggcagcct gctgggggct gccagacacg gggacattat cccttgggac    1080

tatgatgtgg acctgggcat ctacctggag gatgtgggca actgtgagca gctgagaggg    1140

gctgaggctg gctctgtggt ggatgagaga ggctttgtgt gggagaaggc tgtggagggg    1200

gactttttta gagtgcagta ctctgagagc aaccacctgc acgtggacct gtggcctttt    1260

taccctagaa atggggtgat gacaaaggac acatggctgg accacagaca ggatgtggag    1320

tttcctgagc actttctgca gcctctggtg cctctgcctt ttgctggctt tgtggcccag    1380

gcccctaaca actacagaag atttctggag ctgaagtttg gccctggggt gattgagaac    1440

cctcagtacc ctaaccctgc cctgctgagc ctgacaggct ctggctga                 1488


<210> 9
<211> 6903
<212> DNA
<213> Artificial Sequence

<223> "pAAV-hDesmin-hFKRPwt"

<220> 
<223> pAAV-hDesmin-hFKRPwt

<400> 9
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt accttaaacc      420

ggttcctaca tatgggttgc gcaatgcggc cgcagtactg cagaaatagg ccgaaatcgg      480

caaaatccct ttattggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg      540

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg      600

cagagaggga gtggccaact ccatcactag gggttcctta ccccctgccc cccacagctc      660

ctctcctgtg ccttgtttcc cagccatgcg ttctcctcta taaatacccg ctctggtatt      720

tggggttggc agctgttgct gccagggaga tggttgggtt gacatgcggc tcctgacaaa      780

acacaaaccc ctggtgtgtg tgggcgtggg tggtgtgagt agggggatga atcagggagg      840

gggcggggga cccagggggc aggagccaca caaagtctgt gcgggggtgg gagcgcacat      900

agcaattgga aactgaaagc ttatcagacc ctttctggaa atcagcccac tgtttataaa      960

cttgaggccc caccctcgac agtaccgggg aggaagaggg cctgcactag tccagaggga     1020

aactgaggct cagggctagc tcgcccatag acatacatgg caggcaggct ttggccagga     1080

tccctccgcc tgccaggcgt ctccctgccc tcccttcctg cctagagacc cccaccctca     1140

agcctggctg gtctttgcct gagacccaaa cctcttcgac ttcaagagaa tatttaggaa     1200

caaggtggtt tagggccttt cctgggaaca ggccttgacc ctttaagaaa tgacccaaag     1260

tctctccttg accaaaaagg ggaccctcaa actaaaggga agcctctctt ctgctgtctc     1320

ccctgacccc actccccccc accccaggac gaggagataa ccagggctga aagaggcccg     1380

cctgggggct gcagacatgc ttgctgcctg ccctggcgaa ggattggcag gcttgcccgt     1440

cacaggaccc ccgctggctg actcaggggc gcaggcctct tgcgggggag ctggcctccc     1500

cgcccccacg gccacgggcc gccctttcct ggcaggacag cgggatcttg cagctgtcag     1560

gggaggggag gcgggggctg atgtcaggag ggatacaaat agtgccgacg gctgggggcc     1620

ctgtctcccc tcgccgcatc cactctccgg ccggccgcct gcccgccgcc tcctccgtgc     1680

gcccgccagc ctcgcccgcg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1740

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1800

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1860

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1920

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1980

tccagctacc attctgcttt tattttttgg ttgggataag gctggattat tctgagtcca     2040

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     2100

aacgtgctgg tctctgtgct ggcccatcac tttggcaaag aattcgccac catgcggctc     2160

acccgctgcc aggctgccct ggcggccgcc atcaccctca accttctggt cctcttctat     2220

gtctcgtggc tgcagcacca gcctaggaat tcccgggccc gggggccccg tcgtgcctct     2280

gctgccggcc cccgtgtcac cgtcctggtg cgggagttcg aggcatttga caacgcggtg     2340

cccgagctgg tagactcctt cctgcagcaa gacccagccc agcccgtggt ggtggcagcc     2400

gacacgctcc cctacccgcc cctggccctg ccccgcatcc ccaacgtgcg tctggcgctg     2460

ctccagcccg ccctggaccg gccagccgca gcctcgcgcc cggagaccta cgtggccacc     2520

gagtttgtgg ccctagtacc tgatggggcg cgggctgagg cacctggcct gctggagcgc     2580

atggtggagg cgctccgcgc aggaagcgca cgtctggtgg ccgccccggt tgccacggcc     2640

aaccctgcca ggtgcctggc cctgaacgtc agcctgcgag agtggaccgc ccgctatggc     2700

gcagcccccg ccgcgccccg ctgcgacgcc ctggacggag atgctgtggt gctcctgcgc     2760

gcccgcgacc tcttcaacct ctcggcgccc ctggcccggc cggtgggcac cagcctcttt     2820

ctgcagaccg cccttcgcgg ctgggcggtg cagctgctgg acttgacctt cgccgcggcg     2880

cgccagcccc cgctggccac ggcccacgcg cgctggaagg ctgagcgcga gggacgcgct     2940

cggcgggcgg cgctgctccg cgcgctgggc atccgcctag tgagctggga aggcgggcgg     3000

ctggagtggt tcggctgcaa caaggagacc acgcgctgct tcggaaccgt ggtgggcgac     3060

acgcccgcct acctctacga ggagcgctgg acgcccccct gctgcctgcg cgcgctgcgc     3120

gagaccgccc gctatgtggt gggcgtgctg gaggctgcgg gcgtgcgcta ctggctcgag     3180

ggcggctcac tgctgggggc cgcccgccac ggggacatca tcccatggga ctacgacgtg     3240

gacctgggca tctacttgga ggacgtgggc aactgcgagc agctgcgggg ggcagaggcc     3300

ggctcggtgg tggatgagcg cggcttcgta tgggagaagg cggtcgaggg cgactttttc     3360

cgcgtgcagt acagcgaaag caaccacttg cacgtggacc tgtggccctt ctacccccgc     3420

aatggcgtca tgaccaagga cacgtggctg gaccaccggc aggatgtgga gtttcccgag     3480

cacttcctgc agccgctggt gcccctgccc tttgccggct tcgtggcgca ggcgcctaac     3540

aactaccgcc gcttcctgga gctcaagttc gggcccgggg tcatcgagaa cccccagtac     3600

cccaacccgg cactgctgag tctgacggga agcggctgaa ttcaccccac cagtgcaggc     3660

tgcctatcag aaagtggtgg ctggtgtggc taatgccctg gcccacaagt atcactaagc     3720

tcgctttctt gctgtccaat ttctattaaa ggttcctttg ttccctaagt ccaactacta     3780

aactggggga tattatgaag ggccttgagc atctggattc tgcctaataa aaaacattta     3840

ttttcattgc aatgatgtat ttaaattatt tctgaatatt ttactaaaaa gggaatgtgg     3900

gaggtcagtg catttaaaac ataaagaaat gaagagctag ttcaaacctt gggaaaatac     3960

actatatctt aaactccatg aaagaaggtg aggctgcaaa cagctaatgc acattggcaa     4020

cagccctgat gcctatgcct tattcatccc tcagaaaagg attcaagtag aggcttgatt     4080

tggaggttaa agttttgcta tgctgtattt tacattactt attgttttag ctgtcctcat     4140

gaatgtcttt tcactaccca tttgcttatc ctgcatctct cagccttgac tccactcagt     4200

tctcttgctt agagatacca cctttcccct gaagtgttcc ttccatgttt tacggcgaga     4260

tggtttctcc tcgcctggcc actcagcctt agttgtctct gttgtcttat agaggtctac     4320

ttgaagaagg aaaaacaggg ggcatggttt gactgtcctg tgagcccttc ttccctgcct     4380

cccccactca cagtgacccg gaatcaggaa cccctagtga tggagttggc cactccctct     4440

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4500

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa tttgagttct     4560

tctactcagg ttaaacttaa gcgcggccgc agtcctaggt tgcgcaatgg gcatgctaca     4620

gatcttccgc ggtgcagcaa gtcgactgca gaggcctgca tgcaagcttg gcgtaatcat     4680

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     4740

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     4800

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     4860

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     4920

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4980

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5040

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5100

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     5160

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     5220

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     5280

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     5340

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     5400

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     5460

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     5520

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     5580

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     5640

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     5700

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     5760

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     5820

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     5880

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     5940

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6000

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6060

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6120

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     6180

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     6240

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     6300

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     6360

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     6420

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     6480

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     6540

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     6600

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     6660

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     6720

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     6780

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     6840

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     6900

gtc                                                                   6903


<210> 10
<211> 6903
<212> DNA
<213> Artificial Sequence

<223> "pAAV-hDesmin-hFKRP-OPTmin "

<220> 
<223> pAAV-hDesmin-hFKRP-OPTmin

<400> 10
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt accttaaacc      420

ggttcctaca tatgggttgc gcaatgcggc cgcagtactg cagaaatagg ccgaaatcgg      480

caaaatccct ttattggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg      540

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg      600

cagagaggga gtggccaact ccatcactag gggttcctta ccccctgccc cccacagctc      660

ctctcctgtg ccttgtttcc cagccatgcg ttctcctcta taaatacccg ctctggtatt      720

tggggttggc agctgttgct gccagggaga tggttgggtt gacatgcggc tcctgacaaa      780

acacaaaccc ctggtgtgtg tgggcgtggg tggtgtgagt agggggatga atcagggagg      840

gggcggggga cccagggggc aggagccaca caaagtctgt gcgggggtgg gagcgcacat      900

agcaattgga aactgaaagc ttatcagacc ctttctggaa atcagcccac tgtttataaa      960

cttgaggccc caccctcgac agtaccgggg aggaagaggg cctgcactag tccagaggga     1020

aactgaggct cagggctagc tcgcccatag acatacatgg caggcaggct ttggccagga     1080

tccctccgcc tgccaggcgt ctccctgccc tcccttcctg cctagagacc cccaccctca     1140

agcctggctg gtctttgcct gagacccaaa cctcttcgac ttcaagagaa tatttaggaa     1200

caaggtggtt tagggccttt cctgggaaca ggccttgacc ctttaagaaa tgacccaaag     1260

tctctccttg accaaaaagg ggaccctcaa actaaaggga agcctctctt ctgctgtctc     1320

ccctgacccc actccccccc accccaggac gaggagataa ccagggctga aagaggcccg     1380

cctgggggct gcagacatgc ttgctgcctg ccctggcgaa ggattggcag gcttgcccgt     1440

cacaggaccc ccgctggctg actcaggggc gcaggcctct tgcgggggag ctggcctccc     1500

cgcccccacg gccacgggcc gccctttcct ggcaggacag cgggatcttg cagctgtcag     1560

gggaggggag gcgggggctg atgtcaggag ggatacaaat agtgccgacg gctgggggcc     1620

ctgtctcccc tcgccgcatc cactctccgg ccggccgcct gcccgccgcc tcctccgtgc     1680

gcccgccagc ctcgcccgcg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1740

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1800

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1860

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1920

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1980

tccagctacc attctgcttt tattttttgg ttgggataag gctggattat tctgagtcca     2040

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     2100

aacgtgctgg tctctgtgct ggcccatcac tttggcaaag aattcgccac catgcggctc     2160

acccgctgcc aggctgccct ggcggccgcc atcaccctca accttctggt cctcttctat     2220

gtctcgtggc tgcagcacca gcctaggaat tcccgggccc gggggccccg tcgtgcctct     2280

gctgccggcc cccgtgtcac cgtcctggtg cgggagttcg aggcatttga caacgcggtg     2340

cccgagctgg tagactcctt cctgcagcaa gacccagccc agcccgtggt ggtggcagcc     2400

gacacgctcc cctacccgcc cctggccctg ccccgcatcc ccaacgtgcg tctggcgctg     2460

ctccagcccg ccctggaccg gccagccgca gcctcgcgcc cggagaccta cgtggccacc     2520

gagtttgtgg ccctagtacc tgatggggcg cgggctgagg cacctggcct gctggagcgg     2580

atggtggagg cgctccgcgc aggaagcgca cgtctggtgg ccgccccggt tgccacggcc     2640

aaccctgcca ggtgcctggc cctgaacgtc agcctgcgag agtggaccgc ccgctacggc     2700

gcagcccccg ccgcgccccg ctgcgacgcc ctggacggag atgctgtggt gctcctgcgc     2760

gcccgcgacc tcttcaacct ctcggcgccc ctggcccggc cggtgggcac cagcctcttt     2820

ctgcagaccg cccttcgcgg ctgggcggtg cagctgctgg acttgacctt cgccgcggcg     2880

cgccagcccc cgctggccac ggcccacgcg cgctggaagg ctgagcgcga gggacgcgct     2940

cggcgggcgg cgctgctccg cgcgctggga atccgcctag tgagctggga aggcgggcgg     3000

ctggagtggt tcggctgcaa caaggagacc acgcgctgct tcggaaccgt ggtgggcgac     3060

acgcccgcct acctctacga ggagcgctgg acgcccccct gctgcctgcg cgcgctgcgc     3120

gagaccgccc gctatgtggt gggcgtgctg gaggctgcgg gcgtgcgcta ctggctcgag     3180

ggcggctcac tgctgggggc cgcccgccac ggggacatca tcccatggga ctacgacgtg     3240

gacctgggca tctacttgga ggacgtgggc aactgcgagc agctgcgggg ggcagaggcc     3300

ggctcggtgg tggatgagcg cggcttcgta tgggagaagg cggtcgaggg cgactttttc     3360

cgcgtgcagt acagcgaaag caaccacttg cacgtggacc tgtggccctt ctacccccgc     3420

aatggcgtca tgaccaagga cacgtggctg gaccaccggc aggatgtgga gtttcccgag     3480

cacttcctgc agccgctggt gcccctgccc tttgccggct tcgtggcgca ggcgcctaac     3540

aactaccgcc gcttcctgga gctcaagttc gggcccgggg tgatcgagaa cccccagtac     3600

cccaacccgg cactgctgag tctgacggga agcggctgaa ttcaccccac cagtgcaggc     3660

tgcctatcag aaagtggtgg ctggtgtggc taatgccctg gcccacaagt atcactaagc     3720

tcgctttctt gctgtccaat ttctattaaa ggttcctttg ttccctaagt ccaactacta     3780

aactggggga tattatgaag ggccttgagc atctggattc tgcctaataa aaaacattta     3840

ttttcattgc aatgatgtat ttaaattatt tctgaatatt ttactaaaaa gggaatgtgg     3900

gaggtcagtg catttaaaac ataaagaaat gaagagctag ttcaaacctt gggaaaatac     3960

actatatctt aaactccatg aaagaaggtg aggctgcaaa cagctaatgc acattggcaa     4020

cagccctgat gcctatgcct tattcatccc tcagaaaagg attcaagtag aggcttgatt     4080

tggaggttaa agttttgcta tgctgtattt tacattactt attgttttag ctgtcctcat     4140

gaatgtcttt tcactaccca tttgcttatc ctgcatctct cagccttgac tccactcagt     4200

tctcttgctt agagatacca cctttcccct gaagtgttcc ttccatgttt tacggcgaga     4260

tggtttctcc tcgcctggcc actcagcctt agttgtctct gttgtcttat agaggtctac     4320

ttgaagaagg aaaaacaggg ggcatggttt gactgtcctg tgagcccttc ttccctgcct     4380

cccccactca cagtgacccg gaatcaggaa cccctagtga tggagttggc cactccctct     4440

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4500

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa tttgagttct     4560

tctactcagg ttaaacttaa gcgcggccgc agtcctaggt tgcgcaatgg gcatgctaca     4620

gatcttccgc ggtgcagcaa gtcgactgca gaggcctgca tgcaagcttg gcgtaatcat     4680

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     4740

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     4800

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     4860

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     4920

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4980

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5040

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5100

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     5160

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     5220

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     5280

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     5340

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     5400

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     5460

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     5520

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     5580

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     5640

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     5700

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     5760

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     5820

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     5880

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     5940

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6000

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6060

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6120

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     6180

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     6240

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     6300

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     6360

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     6420

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     6480

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     6540

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     6600

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     6660

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     6720

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     6780

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     6840

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     6900

gtc                                                                   6903


<210> 11
<211> 6903
<212> DNA
<213> Artificial Sequence

<223> "pAAV-hDesmin-hFKRP-OPTcomp"

<220> 
<223> pAAV-hDesmin-hFKRP-OPTcomp

<400> 11
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt accttaaacc      420

ggttcctaca tatgggttgc gcaatgcggc cgcagtactg cagaaatagg ccgaaatcgg      480

caaaatccct ttattggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg      540

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg      600

cagagaggga gtggccaact ccatcactag gggttcctta ccccctgccc cccacagctc      660

ctctcctgtg ccttgtttcc cagccatgcg ttctcctcta taaatacccg ctctggtatt      720

tggggttggc agctgttgct gccagggaga tggttgggtt gacatgcggc tcctgacaaa      780

acacaaaccc ctggtgtgtg tgggcgtggg tggtgtgagt agggggatga atcagggagg      840

gggcggggga cccagggggc aggagccaca caaagtctgt gcgggggtgg gagcgcacat      900

agcaattgga aactgaaagc ttatcagacc ctttctggaa atcagcccac tgtttataaa      960

cttgaggccc caccctcgac agtaccgggg aggaagaggg cctgcactag tccagaggga     1020

aactgaggct cagggctagc tcgcccatag acatacatgg caggcaggct ttggccagga     1080

tccctccgcc tgccaggcgt ctccctgccc tcccttcctg cctagagacc cccaccctca     1140

agcctggctg gtctttgcct gagacccaaa cctcttcgac ttcaagagaa tatttaggaa     1200

caaggtggtt tagggccttt cctgggaaca ggccttgacc ctttaagaaa tgacccaaag     1260

tctctccttg accaaaaagg ggaccctcaa actaaaggga agcctctctt ctgctgtctc     1320

ccctgacccc actccccccc accccaggac gaggagataa ccagggctga aagaggcccg     1380

cctgggggct gcagacatgc ttgctgcctg ccctggcgaa ggattggcag gcttgcccgt     1440

cacaggaccc ccgctggctg actcaggggc gcaggcctct tgcgggggag ctggcctccc     1500

cgcccccacg gccacgggcc gccctttcct ggcaggacag cgggatcttg cagctgtcag     1560

gggaggggag gcgggggctg atgtcaggag ggatacaaat agtgccgacg gctgggggcc     1620

ctgtctcccc tcgccgcatc cactctccgg ccggccgcct gcccgccgcc tcctccgtgc     1680

gcccgccagc ctcgcccgcg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1740

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1800

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1860

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1920

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1980

tccagctacc attctgcttt tattttttgg ttgggataag gctggattat tctgagtcca     2040

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     2100

aacgtgctgg tctctgtgct ggcccatcac tttggcaaag aattcgccac catgagactg     2160

accaggtgcc aggctgccct ggctgctgcc atcaccctga acctgctggt gctgttctat     2220

gtgagctggc tgcagcacca gcccaggaac agcagggcca ggggccccag gagggcctct     2280

gctgctggcc ccagggtgac agtgctggtg agggagtttg aggcctttga caatgctgtg     2340

cctgagctgg tggacagctt cctgcagcag gaccctgccc agcctgtggt ggtggctgct     2400

gataccctgc cctacccccc cctggccctg cccaggatcc ccaatgtgag gctggccctg     2460

ctgcagcctg ccctggacag gcctgctgct gccagcaggc ctgagaccta tgtggccaca     2520

gagtttgtgg ccctggtgcc tgatggggcc agggctgagg cccctggcct gctggagagg     2580

atggtggagg ccctgagggc tggctctgcc aggctggtgg ctgcccctgt ggccacagcc     2640

aaccctgcca ggtgcctggc cctgaatgtg agcctgagag agtggacagc caggtatggg     2700

gctgcccctg ctgcccccag gtgtgatgcc ctggatggag atgctgtggt gctgctgagg     2760

gccagggacc tgttcaacct gtctgccccc ctggccaggc ctgtggggac cagcctgttt     2820

ctgcagacag ccctgagggg ctgggctgtg cagctgctgg acctgacctt tgctgctgcc     2880

aggcagcccc ccctggctac agcccacgcc aggtggaagg ctgagaggga gggcagggcc     2940

aggagggctg ccctgctgag ggccctgggg atcaggctgg tgagctggga ggggggcagg     3000

ctggagtggt ttggctgcaa caaggagaca accaggtgct ttgggacagt ggtgggggat     3060

acccctgcct acctgtatga ggagaggtgg acccccccct gctgcctgag ggccctgagg     3120

gagacagcca ggtatgtggt gggggtgctg gaggctgctg gggtgaggta ctggctggag     3180

gggggcagcc tgctgggggc tgccaggcac ggggacatta tcccctggga ctatgatgtg     3240

gacctgggca tctacctgga ggatgtgggc aactgtgagc agctgagggg ggctgaggct     3300

ggctctgtgg tggatgagag gggctttgtg tgggagaagg ctgtggaggg ggactttttc     3360

agggtgcagt actctgagag caaccacctg cacgtggacc tgtggccctt ctaccccagg     3420

aatggggtga tgaccaagga cacctggctg gaccacaggc aggatgtgga gttccctgag     3480

cacttcctgc agcccctggt gcccctgccc tttgctggct ttgtggccca ggcccccaac     3540

aactacagga ggttcctgga gctgaagttt ggccctgggg tgattgagaa cccccagtac     3600

cccaaccctg ccctgctgag cctgacaggc tctggctgaa ttcaccccac cagtgcaggc     3660

tgcctatcag aaagtggtgg ctggtgtggc taatgccctg gcccacaagt atcactaagc     3720

tcgctttctt gctgtccaat ttctattaaa ggttcctttg ttccctaagt ccaactacta     3780

aactggggga tattatgaag ggccttgagc atctggattc tgcctaataa aaaacattta     3840

ttttcattgc aatgatgtat ttaaattatt tctgaatatt ttactaaaaa gggaatgtgg     3900

gaggtcagtg catttaaaac ataaagaaat gaagagctag ttcaaacctt gggaaaatac     3960

actatatctt aaactccatg aaagaaggtg aggctgcaaa cagctaatgc acattggcaa     4020

cagccctgat gcctatgcct tattcatccc tcagaaaagg attcaagtag aggcttgatt     4080

tggaggttaa agttttgcta tgctgtattt tacattactt attgttttag ctgtcctcat     4140

gaatgtcttt tcactaccca tttgcttatc ctgcatctct cagccttgac tccactcagt     4200

tctcttgctt agagatacca cctttcccct gaagtgttcc ttccatgttt tacggcgaga     4260

tggtttctcc tcgcctggcc actcagcctt agttgtctct gttgtcttat agaggtctac     4320

ttgaagaagg aaaaacaggg ggcatggttt gactgtcctg tgagcccttc ttccctgcct     4380

cccccactca cagtgacccg gaatcaggaa cccctagtga tggagttggc cactccctct     4440

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4500

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa tttgagttct     4560

tctactcagg ttaaacttaa gcgcggccgc agtcctaggt tgcgcaatgg gcatgctaca     4620

gatcttccgc ggtgcagcaa gtcgactgca gaggcctgca tgcaagcttg gcgtaatcat     4680

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     4740

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     4800

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     4860

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     4920

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4980

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5040

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5100

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     5160

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     5220

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     5280

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     5340

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     5400

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     5460

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     5520

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     5580

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     5640

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     5700

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     5760

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     5820

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     5880

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     5940

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6000

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6060

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6120

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     6180

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     6240

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     6300

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     6360

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     6420

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     6480

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     6540

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     6600

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     6660

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     6720

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     6780

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     6840

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     6900

gtc                                                                   6903


<210> 12
<211> 145
<212> DNA
<213> Artificial Sequence

<223> "ITR 5'"

<220> 
<223> ITR 5'

<400> 12
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg    120

gccaactcca tcactagggg ttcct                                          145


<210> 13
<211> 1061
<212> DNA
<213> Artificial Sequence

<223> "human desmin promoter"

<220> 
<223> human desmin promoter

<400> 13
taccccctgc cccccacagc tcctctcctg tgccttgttt cccagccatg cgttctcctc      60

tataaatacc cgctctggta tttggggttg gcagctgttg ctgccaggga gatggttggg     120

ttgacatgcg gctcctgaca aaacacaaac ccctggtgtg tgtgggcgtg ggtggtgtga     180

gtagggggat gaatcaggga gggggcgggg gacccagggg gcaggagcca cacaaagtct     240

gtgcgggggt gggagcgcac atagcaattg gaaactgaaa gcttatcaga ccctttctgg     300

aaatcagccc actgtttata aacttgaggc cccaccctcg acagtaccgg ggaggaagag     360

ggcctgcact agtccagagg gaaactgagg ctcagggcta gctcgcccat agacatacat     420

ggcaggcagg ctttggccag gatccctccg cctgccaggc gtctccctgc cctcccttcc     480

tgcctagaga cccccaccct caagcctggc tggtctttgc ctgagaccca aacctcttcg     540

acttcaagag aatatttagg aacaaggtgg tttagggcct ttcctgggaa caggccttga     600

ccctttaaga aatgacccaa agtctctcct tgaccaaaaa ggggaccctc aaactaaagg     660

gaagcctctc ttctgctgtc tcccctgacc ccactccccc ccaccccagg acgaggagat     720

aaccagggct gaaagaggcc cgcctggggg ctgcagacat gcttgctgcc tgccctggcg     780

aaggattggc aggcttgccc gtcacaggac ccccgctggc tgactcaggg gcgcaggcct     840

cttgcggggg agctggcctc cccgccccca cggccacggg ccgccctttc ctggcaggac     900

agcgggatct tgcagctgtc aggggagggg aggcgggggc tgatgtcagg agggatacaa     960

atagtgccga cggctggggg ccctgtctcc cctcgccgca tccactctcc ggccggccgc    1020

ctgcccgccg cctcctccgt gcgcccgcca gcctcgcccg c                        1061


<210> 14
<211> 452
<212> DNA
<213> Artificial Sequence

<223> "HBB2 intron followed by Kozak sequence"

<220> 
<223> HBB2 intron followed by Kozak sequence

<400> 14
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt      60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca     120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata     180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt     240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt     300

ttattttttg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa     360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctctgtgc     420

tggcccatca ctttggcaaa gaattcgcca cc                                   452


<210> 15
<211> 766
<212> DNA
<213> Artificial Sequence

<223> "HBB2 polyA"

<220> 
<223> HBB2 polyA

<400> 15
attcacccca ccagtgcagg ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct      60

ggcccacaag tatcactaag ctcgctttct tgctgtccaa tttctattaa aggttccttt     120

gttccctaag tccaactact aaactggggg atattatgaa gggccttgag catctggatt     180

ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat     240

tttactaaaa agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa tgaagagcta     300

gttcaaacct tgggaaaata cactatatct taaactccat gaaagaaggt gaggctgcaa     360

acagctaatg cacattggca acagccctga tgcctatgcc ttattcatcc ctcagaaaag     420

gattcaagta gaggcttgat ttggaggtta aagttttgct atgctgtatt ttacattact     480

tattgtttta gctgtcctca tgaatgtctt ttcactaccc atttgcttat cctgcatctc     540

tcagccttga ctccactcag ttctcttgct tagagatacc acctttcccc tgaagtgttc     600

cttccatgtt ttacggcgag atggtttctc ctcgcctggc cactcagcct tagttgtctc     660

tgttgtctta tagaggtcta cttgaagaag gaaaaacagg gggcatggtt tgactgtcct     720

gtgagccctt cttccctgcc tcccccactc acagtgaccc ggaatc                    766


<210> 16
<211> 145
<212> DNA
<213> Artificial Sequence

<223> "ITR 3’"

<220> 
<223> ITR 3’

<400> 16
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag agagggagtg gccaa                                          145


<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<223> "Forward HBB2 polyA "

<220> 
<223> Forward HBB2 polyA

<400> 17
ccaggcgagg agaaacca                                                  18


<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<223> "Reverse HBB2 polyA "

<220> 
<223> Reverse HBB2 polyA

<400> 18
cttgactcca ctcagttctc ttgct                                          25


<210> 19
<211> 29
<212> DNA
<213> Artificial Sequence

<223> "Probe HBB2 polyA "

<220> 
<223> Probe HBB2 polyA

<400> 19
ctcgccgtaa aacatggaag gaacacttc                                      29


<210> 20
<211> 1488
<212> DNA
<213> Artificial Sequence

<223> "WO2016/138387 (FKRP-06)"

<220> 
<223> WO2016/138387 (FKRP-06)

<400> 20
atgagactga caagatgcca ggccgccctg gccgctgcca tcacactgaa tctgctggtg      60

ctgttctatg tgtcctggct gcagcaccag ccccggaact ctagagccag aggcccaaga     120

agggcctctg ccgccggacc tagagtgaca gtgctcgtgc gcgagttcga ggccttcgac     180

aatgccgtgc ccgagctggt ggacagcttc ctgcagcaag accctgctca gcctgtggtg     240

gtggccgccg atacactgcc ttatcctcca ctggccctgc ccagaatccc caatgtgcga     300

ctggctctgc tgcagcccgc cctggataga cctgccgccg ctagcagacc tgagacatac     360

gtggccaccg agttcgtggc cctggtgcct gatggcgcca gagctgaagc tcccggcctg     420

ctggaaagaa tggtggaagc cctgagagcc ggcagcgcca gactggtggc tgctcctgtg     480

gctaccgcca accctgccag atgtctggcc ctgaatgtgt ccctgagaga gtggaccgcc     540

agatacggcg ctgcccctgc cgctcctaga tgtgatgctc tggatggcga cgccgtggtg     600

ctgctgagag ccagggacct gttcaacctg agcgcccctc tggccagacc tgtgggcaca     660

agcctgtttc tgcagacagc cctgaggggc tgggccgtgc agctgctgga tctgacattt     720

gccgctgcca gacagcctcc tctggccaca gcccatgcca gatggaaggc cgagagagag     780

ggcagagcca gaagggctgc tctgctgagg gccctgggca tcagactggt gtcttgggaa     840

ggcggcagac tcgagtggtt cggctgcaac aaagaaacca cccggtgctt cggcaccgtc     900

gtgggcgata caccagccta cctgtacgag gaaagatgga cccccccttg ctgcctgcgg     960

gccctgagag aaacagccag atatgtcgtg ggcgtgctgg aagccgctgg cgtgcgatat    1020

tggctggaag gcggatctct gctgggagcc gccaggcacg gcgacatcat cccttgggac    1080

tacgacgtgg acctgggcat ctacctggaa gatgtgggca actgcgagca gctgagaggc    1140

gccgaagccg gctctgtggt ggatgagagg ggcttcgtgt gggagaaggc cgtggaaggc    1200

gacttcttcc gggtgcagta cagcgagagc aaccatctgc atgtggacct gtggcccttc    1260

tacccccgga acggcgtgat gaccaaggac acctggctgg accaccggca ggacgtggaa    1320

ttccccgagc actttctgca gcccctggtg ccactgcctt tcgccggatt tgtggcccag    1380

gcccccaaca actaccggcg gttcctggaa ctgaagttcg gccctggcgt gatcgagaac    1440

ccccagtacc ctaaccctgc cctgctgagc ctgaccggca gcggctaa                 1488


<210> 21
<211> 6903
<212> DNA
<213> Artificial Sequence

<223> "pAAV-hDesmin-hFKRP-OPT08"

<220> 
<223> pAAV-hDesmin-hFKRP-OPT08

<400> 21
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt accttaaacc      420

ggttcctaca tatgggttgc gcaatgcggc cgcagtactg cagaaatagg ccgaaatcgg      480

caaaatccct ttattggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg      540

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg      600

cagagaggga gtggccaact ccatcactag gggttcctta ccccctgccc cccacagctc      660

ctctcctgtg ccttgtttcc cagccatgcg ttctcctcta taaatacccg ctctggtatt      720

tggggttggc agctgttgct gccagggaga tggttgggtt gacatgcggc tcctgacaaa      780

acacaaaccc ctggtgtgtg tgggcgtggg tggtgtgagt agggggatga atcagggagg      840

gggcggggga cccagggggc aggagccaca caaagtctgt gcgggggtgg gagcgcacat      900

agcaattgga aactgaaagc ttatcagacc ctttctggaa atcagcccac tgtttataaa      960

cttgaggccc caccctcgac agtaccgggg aggaagaggg cctgcactag tccagaggga     1020

aactgaggct cagggctagc tcgcccatag acatacatgg caggcaggct ttggccagga     1080

tccctccgcc tgccaggcgt ctccctgccc tcccttcctg cctagagacc cccaccctca     1140

agcctggctg gtctttgcct gagacccaaa cctcttcgac ttcaagagaa tatttaggaa     1200

caaggtggtt tagggccttt cctgggaaca ggccttgacc ctttaagaaa tgacccaaag     1260

tctctccttg accaaaaagg ggaccctcaa actaaaggga agcctctctt ctgctgtctc     1320

ccctgacccc actccccccc accccaggac gaggagataa ccagggctga aagaggcccg     1380

cctgggggct gcagacatgc ttgctgcctg ccctggcgaa ggattggcag gcttgcccgt     1440

cacaggaccc ccgctggctg actcaggggc gcaggcctct tgcgggggag ctggcctccc     1500

cgcccccacg gccacgggcc gccctttcct ggcaggacag cgggatcttg cagctgtcag     1560

gggaggggag gcgggggctg atgtcaggag ggatacaaat agtgccgacg gctgggggcc     1620

ctgtctcccc tcgccgcatc cactctccgg ccggccgcct gcccgccgcc tcctccgtgc     1680

gcccgccagc ctcgcccgcg tacacatatt gaccaaatca gggtaatttt gcatttgtaa     1740

ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt     1800

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1860

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1920

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1980

tccagctacc attctgcttt tattttttgg ttgggataag gctggattat tctgagtcca     2040

agctaggccc ttttgctaat cttgttcata cctcttatct tcctcccaca gctcctgggc     2100

aacgtgctgg tctctgtgct ggcccatcac tttggcaaag aattcgccac catgcggctc     2160

acccgctgcc aggctgccct ggctgctgcc atcaccctca accttctggt cctcttctat     2220

gtcagctggc tgcagcacca gcctaggaat tcccgggccc gggggcccag gagggcctct     2280

gctgctggcc ccagggtcac cgtcctggtg cgggagttcg aggcatttga caacgctgtg     2340

cccgagctgg tagactcctt cctgcagcaa gacccagccc agcccgtggt ggtggcagct     2400

gacaccctcc cctacccccc cctggccctg ccccgcatcc ccaacgtgag gctggccctg     2460

ctccagcccg ccctggaccg gccagctgca gccagccgcc ctgagaccta cgtggccacc     2520

gagtttgtgg ccctggtacc tgatggggcc cgggctgagg cacctggcct gctggagcgg     2580

atggtggagg ccctcagggc aggaagcgca aggctggtgg ctgcccctgt tgccacagcc     2640

aaccctgcca ggtgcctggc cctgaacgtc agcctgcgag agtggaccgc ccgctacggg     2700

gcagcccccg ctgccccccg ctgcgacgcc ctggacggag atgctgtggt gctcctgagg     2760

gccagggacc tcttcaacct ctctgccccc ctggcccggc ctgtgggcac cagcctcttt     2820

ctgcagaccg cccttagggg ctgggctgtg cagctgctgg acttgacctt cgctgctgcc     2880

cgccagcccc ccctggccac agcccacgcc cgctggaagg ctgagaggga gggaagggct     2940

cggcgggctg ccctgctcag ggccctggga atccgcctgg tgagctggga aggggggcgg     3000

ctggagtggt tcggctgcaa caaggagacc acccgctgct tcggaaccgt ggtgggggac     3060

acccccgcct acctctacga ggagcgctgg acccccccct gctgcctgag ggccctgagg     3120

gagaccgccc gctatgtggt gggggtgctg gaggctgctg gggtgcgcta ctggctcgag     3180

gggggctcac tgctgggggc tgcccgccac ggggacatca tcccatggga ctacgacgtg     3240

gacctgggca tctacttgga ggacgtgggc aactgcgagc agctgcgggg ggcagaggct     3300

ggctctgtgg tggatgagag gggcttcgta tgggagaagg ctgtggaggg ggactttttc     3360

agggtgcagt acagcgaaag caaccacttg cacgtggacc tgtggccctt ctacccccgc     3420

aatggggtca tgaccaagga cacctggctg gaccaccggc aggatgtgga gtttcccgag     3480

cacttcctgc agcccctggt gcccctgccc tttgctggct tcgtggccca ggcccctaac     3540

aactaccgcc gcttcctgga gctcaagttc gggcccgggg tgatcgagaa cccccagtac     3600

cccaaccctg cactgctgag tctgaccgga agcggctgaa ttcaccccac cagtgcaggc     3660

tgcctatcag aaagtggtgg ctggtgtggc taatgccctg gcccacaagt atcactaagc     3720

tcgctttctt gctgtccaat ttctattaaa ggttcctttg ttccctaagt ccaactacta     3780

aactggggga tattatgaag ggccttgagc atctggattc tgcctaataa aaaacattta     3840

ttttcattgc aatgatgtat ttaaattatt tctgaatatt ttactaaaaa gggaatgtgg     3900

gaggtcagtg catttaaaac ataaagaaat gaagagctag ttcaaacctt gggaaaatac     3960

actatatctt aaactccatg aaagaaggtg aggctgcaaa cagctaatgc acattggcaa     4020

cagccctgat gcctatgcct tattcatccc tcagaaaagg attcaagtag aggcttgatt     4080

tggaggttaa agttttgcta tgctgtattt tacattactt attgttttag ctgtcctcat     4140

gaatgtcttt tcactaccca tttgcttatc ctgcatctct cagccttgac tccactcagt     4200

tctcttgctt agagatacca cctttcccct gaagtgttcc ttccatgttt tacggcgaga     4260

tggtttctcc tcgcctggcc actcagcctt agttgtctct gttgtcttat agaggtctac     4320

ttgaagaagg aaaaacaggg ggcatggttt gactgtcctg tgagcccttc ttccctgcct     4380

cccccactca cagtgacccg gaatcaggaa cccctagtga tggagttggc cactccctct     4440

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4500

gcccgggcgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa tttgagttct     4560

tctactcagg ttaaacttaa gcgcggccgc agtcctaggt tgcgcaatgg gcatgctaca     4620

gatcttccgc ggtgcagcaa gtcgactgca gaggcctgca tgcaagcttg gcgtaatcat     4680

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     4740

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     4800

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     4860

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     4920

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4980

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5040

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5100

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     5160

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     5220

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     5280

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     5340

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     5400

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     5460

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     5520

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     5580

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     5640

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     5700

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     5760

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     5820

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     5880

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     5940

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6000

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6060

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6120

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     6180

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     6240

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     6300

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     6360

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     6420

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     6480

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     6540

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     6600

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     6660

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     6720

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     6780

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     6840

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     6900

gtc                                                                   6903


