﻿               SEQUENCE LISTING

<110> Klapproth Holger
      Birnser Ulrich
      Kessemeier Marc
      Jumaa Hassan

<120> Therapeutischer Antikörper zur Therapie der CLL

<130> CLL-Epitop

<160> 16

<170> BiSSAP 1.3.6

<210> 1
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 2/1

<400> 1
Lys Leu Thr Val Leu Arg Gln Pro Lys Ala 
1               5                   10  

<210> 2
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 2/2

<400> 2
Val Ala Pro Gly Lys Thr Ala Arg 
1               5               

<210> 3
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Autonom aktiver Bereich Subset 4/1

<400> 3
Pro Thr Ile Arg Arg Tyr Tyr Tyr Tyr Gly 
1               5                   10  

<210> 4
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 4/2

<400> 4
Asn His Lys Pro Ser Asn Thr Lys Val 
1               5                   

<210> 5
<211> 116
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 2 VH

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ile Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gln Asn Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 6
<211> 215
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 2 LC

<400> 6
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Ala Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Ser Asp His 
                85                  90                  95      
Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Thr Glu Cys Ser 
    210                 215 

<210> 7
<211> 224
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 4 HC

<400> 7
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Tyr Gly Asp Thr Pro Thr Ile Arg Arg Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     
His Thr Phe Pro Ala Cys Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Cys 
    210                 215                 220                  

<210> 8
<211> 220
<212> PRT
<213> Homo sapiens


<220> 
<223> Autonom aktiver Bereich Subset 4 LC

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asp Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      
Thr His Trp Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 9
<211> 119
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 HC

<400> 9
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Arg Gly Gly Gly Thr Asp Ser Asn Ala Ala Phe Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Arg Tyr Asp Glu Glu Glu Ser Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser 
        115                 

<210> 10
<211> 107
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 LC

<400> 10
Gln Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Asn Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 11
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR1 HC

<400> 11
Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               

<210> 12
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR2 HC

<400> 12
Ile Trp Arg Gly Gly Gly Thr 
1               5           

<210> 13
<211> 13
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR3 HC

<400> 13
Ala Arg Ser Arg Tyr Asp Glu Glu Glu Ser Met Asn Tyr 
1               5                   10              

<210> 14
<211> 6
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR1 LC

<400> 14
Gly Asn Ile His Ser Tyr 
1               5       

<210> 15
<211> 4
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR2 LC

<400> 15
Asn Ala Lys Thr 
1               

<210> 16
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> AVA mAb01 CDR3 LC

<400> 16
Gln His Phe Trp Asn Thr Pro Pro Thr 
1               5                   


<210> 17
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> Autonom aktiver Bereich Subset 4/2

<400> 17
Val Ser Ser Ala Ser Thr Lys Gly 
1               5               



