                         SEQUENCE LISTING

<110>  AdvanceCOR GmbH
 
<120>  Fusion Protein

<130>  PCT-17396

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  929
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg Ser Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr Pro Ser Arg Leu 
            180                 185                 190         


Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser Glu Ala Thr Ala 
        195                 200                 205             


Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr Thr Glu Thr Ser 
    210                 215                 220                 


Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser Pro Ala Gly Pro 
225                 230                 235                 240 


Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Gly Gly Arg Val Glu Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gln Asn Lys Ala Leu 
                485                 490                 495     


Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His 
            500                 505                 510         


Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr 
        515                 520                 525             


Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile 
    530                 535                 540                 


Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp 
545                 550                 555                 560 


Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu 
                565                 570                 575     


Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met 
            580                 585                 590         


Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser 
        595                 600                 605             


Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly 
    610                 615                 620                 


Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly 
625                 630                 635                 640 


Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr 
                645                 650                 655     


Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr 
            660                 665                 670         


Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn 
        675                 680                 685             


Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His 
    690                 695                 700                 


Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala 
705                 710                 715                 720 


Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe 
                725                 730                 735     


His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr 
            740                 745                 750         


Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu 
        755                 760                 765             


Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu 
    770                 775                 780                 


Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly 
785                 790                 795                 800 


Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe 
                805                 810                 815     


Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln 
            820                 825                 830         


Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu 
        835                 840                 845             


Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu 
    850                 855                 860                 


Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr 
865                 870                 875                 880 


His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile 
                885                 890                 895     


Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr 
            900                 905                 910         


Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser 
        915                 920                 925             


Thr 
    


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(249)

<400>  2

Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala Leu Pro Ser Ser 
1               5                   10                  15      


Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys Gln Gly Pro Pro 
            20                  25                  30          


Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser Ser Arg Tyr Gln 
        35                  40                  45              


Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg Ser Leu Ala Gly 
    50                  55                  60                  


Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp Ser Leu Pro Ser 
65                  70                  75                  80  


Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly Asp Val Thr Leu 
            100                 105                 110         


Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala Leu Tyr Lys Glu 
        115                 120                 125             


Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp Tyr Arg Ala Ser 
    130                 135                 140                 


Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly Thr Tyr Arg Cys 
145                 150                 155                 160 


Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser Ala Pro Ser Asp 
                165                 170                 175     


Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr Pro Ser Arg Leu 
            180                 185                 190         


Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser Glu Ala Thr Ala 
        195                 200                 205             


Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr Thr Glu Thr Ser 
    210                 215                 220                 


Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser Pro Ala Gly Pro 
225                 230                 235                 240 


Ala Arg Gln Tyr Tyr Thr Lys Gly Asn 
                245                 


<210>  3
<211>  223
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(223)

<400>  3

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  4
<211>  439
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(439)

<400>  4

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu 
1               5                   10                  15      


Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala 
            20                  25                  30          


Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg 
        35                  40                  45              


Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile 
    50                  55                  60                  


Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro 
65                  70                  75                  80  


Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly 
                85                  90                  95      


Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu 
            100                 105                 110         


Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly 
        115                 120                 125             


Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr 
    130                 135                 140                 


Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser 
145                 150                 155                 160 


Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp 
                165                 170                 175     


Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr 
            180                 185                 190         


Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp 
        195                 200                 205             


Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala 
    210                 215                 220                 


Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile 
225                 230                 235                 240 


Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val 
                245                 250                 255     


Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu 
            260                 265                 270         


Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys 
        275                 280                 285             


His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser 
    290                 295                 300                 


Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe 
305                 310                 315                 320 


Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr 
                325                 330                 335     


Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe 
            340                 345                 350         


Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys 
        355                 360                 365             


Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser 
    370                 375                 380                 


Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile 
385                 390                 395                 400 


His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly 
                405                 410                 415     


Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser 
            420                 425                 430         


Thr Pro Leu Ser His Ser Thr 
        435                 


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(15)

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  2847
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(2847)

<400>  6
atggaaaccc ctgctcagct gctgttcctg ctgctgctgt ggctgcctga caccaccggc       60

cagtccggac ctctgcctaa gccttccctg caggccctgc cttcctccct ggtgcctctg      120

gaaaagcctg tgaccctgag gtgtcaggga cctcctggcg tggacctgta ccggctggaa      180

aagctgtcct ccagcagata ccaggaccag gccgtgctgt tcatccctgc catgaagcgg      240

tccctggccg gcaggtacag gtgctcctac cagaacggct ccctgtggtc tctgccttct      300

gaccagctgg aactggtggc taccggcgtg ttcgccaagc cttctctgtc tgcccagcct      360

ggacctgctg tctcctctgg aggcgacgtg acactgcagt gccagaccag atacggcttc      420

gatcagttcg ccctgtacaa agagggcgac cctgcccctt acaagaaccc tgagcggtgg      480

tacagggcct ccttccctat catcaccgtg accgccgctc actccggcac ctaccggtgc      540

tacagcttct cctcccggga cccttacctg tggtccgccc ctagcgaccc tctcgaactg      600

gtcgtcaccg gaacctccgt gaccccttcc aggctgccta ccgagcctcc tagctccgtg      660

gccgagttct ctgaggccac cgccgagctg accgtgtcct tcaccaacaa ggtgttcacc      720

accgagacat cccggtccat caccacctcc cccaaagagt ccgactctcc tgccggccct      780

gctcggcagt actacaccaa gggcaacggc ggcagagtgg agtgtcctcc ttgccctgcc      840

cctcctgtgg ctggcccttc cgtgttcctg ttccctccaa agcctaagga caccctgatg      900

atctcccgga cccctgaagt gacctgcgtg gtggtggacg tgtcccacga ggaccctgag      960

gtgcagttca attggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg     1020

gaggaacagt tcaactccac cttccgggtg gtgtccgtgc tgaccgtggt gcaccaggac     1080

tggctgaacg gcaaagaata caagtgcaag gtgtccaaca agggcctgcc tgcccctatc     1140

gaaaagacca tcagcaagac caagggacag cctcgcgagc ctcaggtgta caccctgcct     1200

ccaagccggg aggaaatgac caagaaccag gtgtccctga cctgcctggt caagggcttc     1260

tacccttccg atatcgccgt ggagtgggag tctaacggcc agcctgagaa caactacaag     1320

accacccctc ctatgctgga ctccgacggc tccttcttcc tgtactccaa actgaccgtg     1380

gacaagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg     1440

cacaaccact acacccagaa gtccctgtcc ctgtctcctg gcaagggtgg aggcggttca     1500

ggcggaggtg gcagcggcgg tggcggatcg acccagaaca aggccctgcc tgagaacgtg     1560

aagtacggca tcgtgctgga tgctggctcc tcccacacct ccctgtacat ctacaagtgg     1620

cctgccgaga aagaaaacga caccggcgtg gtgcaccagg tggaggaatg cagagtgaag     1680

ggccctggca tctccaagtt cgtgcagaaa gtgaacgaga tcggcatcta cctgaccgac     1740

tgcatggaac gggccaggga agtgatccct cggtcccagc atcaggaaac ccccgtctac     1800

ctgggcgcta ccgccggcat gcggctgctg cggatggaat ccgaggaact ggccgacagg     1860

gtgctggacg tggtggagcg gtccctgtcc aactacccat tcgactttca gggcgccagg     1920

atcatcaccg gccaggaaga gggcgcttac ggctggatca ccatcaacta cctgctgggc     1980

aagttctccc agaaaacccg gtggttctcc atcgtgccct acgagacaaa caaccaggaa     2040

accttcggcg ctctggatct gggcggagcc tctacccagg tgaccttcgt gcctcagaac     2100

cagaccatcg agtcccccga caacgccctg cagttccggc tgtacggcaa ggactacaac     2160

gtgtacaccc acagctttct gtgctatggc aaggaccagg ccctgtggca gaagctggcc     2220

aaggacatcc aggtggcctc caacgagatc ctgcgggacc cttgcttcca ccctggctac     2280

aagaaagtgg tgaacgtgtc cgacctgtac aagacccctt gcaccaagcg gttcgagatg     2340

accctgcctt tccagcagtt cgagatccag ggcatcggca actaccagca gtgccaccag     2400

tccatcctgg aactgttcaa caccagctac tgcccttact cccagtgcgc cttcaacggc     2460

atcttcctgc cccctctgca gggcgacttc ggcgccttct ccgccttcta cttcgtgatg     2520

aagttcctga acctgacctc cgagaaggtg tcccaagaaa aagtgaccga gatgatgaag     2580

aagttctgcg cccagccttg ggaggaaatc aagacctcct acgctggcgt gaaagagaag     2640

tacctgtccg agtactgctt ctccggcacc tacatcctgt ctctgctgct gcagggctac     2700

cacttcaccg ccgactcttg ggagcacatc cacttcatcg gcaagatcca gggaagcgac     2760

gccggctgga ccctgggcta catgctgaat ctgaccaaca tgatccctgc cgagcagcct     2820

ctgtccaccc ctctgtccca ctccacc                                         2847


<210>  7
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<400>  7

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


