                         SEQUENCE LISTING

<110>  Memorial Sloan Kettering
 
<120>  COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER

<130>  115872-0383

<150>  62/527,925
<151>  2017-06-30

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ser Ile His Arg Thr Ala Ile Ala Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Phe Val Ala Gly Thr Ala Leu Ala Gln Lys Arg Asp Asn Val Leu 
            20                  25                  30          


Phe Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu 
        35                  40                  45              


Lys Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala 
    50                  55                  60                  


Ala Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr 
65                  70                  75                  80  


Val Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val 
                85                  90                  95      


Gly Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His 
            100                 105                 110         


Met Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg 
        115                 120                 125             


Val Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly 
    130                 135                 140                 


Gly Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly 
145                 150                 155                 160 


Val Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu 
                165                 170                 175     


Lys Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu 
            180                 185                 190         


Ala Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys 
        195                 200                 205             


Leu Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Asn Ile Thr 
    210                 215                 220                 


Gly Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala 
225                 230                 235                 240 


Leu Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp 
                245                 250                 255     


Lys Ala Lys Asn Leu Arg Phe Asn Trp Thr Ile Ala Lys Ala Gly Asn 
            260                 265                 270         


Val Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg 
        275                 280                 285             


Tyr Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu 
    290                 295                 300                 


Arg Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val 
305                 310                 315                 320 


Thr Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu 
                325                 330                 335     


Val Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly 
            340                 345                 350         


Val Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu 
        355                 360                 365             


Ser Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr 
    370                 375                 380                 


His Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg 
385                 390                 395                 400 


Leu Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys 
                405                 410                 415 


<210>  2
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcgtccct ctatccatcg tacggccatt gcggctgtat tagccacagc gtttgtagcg       60

ggcacggcct tggctcagaa acgtgacaac gtactgttcc aagcagctac tgacgagcaa      120

cccgccgtta ttaaaacatt agagaaattg gtaaatattg aaactgggac gggcgacgct      180

gaaggcattg ccgcggctgg gaacttcttg gaagccgaat taaaaaatct tgggtttaca      240

gtcactcgct cgaaatcagc ggggctggtc gttggtgata acatcgtcgg caaaattaaa      300

gggcgcgggg gtaaaaattt attgttgatg agccacatgg acaccgttta cctgaaaggg      360

atccttgcga aagccccctt tcgcgtcgag ggagacaagg cttacggtcc cggcatcgca      420

gatgataaag gtggaaatgc agtgatttta cacacactga aattgcttaa agagtacgga      480

gttcgcgatt acggcacgat cacagtattg ttcaatacgg acgaggaaaa gggatctttc      540

ggcagccgtg atcttatcca ggaagaagcg aaactggcgg attatgtgtt aagttttgaa      600

cccacaagcg ccggagatga gaagctttca ttaggtacat caggtattgc ctacgtacag      660

gtaaatatca caggtaaagc aagccacgca ggggcggcac cagagttagg cgttaatgca      720

ctggtagaag ctagtgacct ggtccttcgt actatgaata tcgatgataa agcgaaaaac      780

ttgcgcttta actggacgat cgccaaggcg ggtaatgtat cgaacattat tccagccagt      840

gcgacattaa atgctgatgt tcgttacgcg cgcaatgaag acttcgacgc tgctatgaaa      900

acacttgagg agcgcgctca acagaaaaaa cttccagagg ccgacgtaaa agttatcgtt      960

acacgtggac gtccggcctt taacgcgggt gaaggaggca agaagctggt agacaaagct     1020

gttgcttatt ataaagaagc ggggggaacc ttgggagtgg aggaacgtac cggtggaggg     1080

actgatgcgg cttacgccgc actttctgga aagcctgtaa tcgagagctt aggtttaccc     1140

ggttttgggt atcacagtga taaagcagag tacgtcgata tttcagcgat cccacgccgt     1200

ctttatatgg ctgcccgctt gattatggat ttgggggcgg ggaagtag                  1248


<210>  3
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Leu Ala Gln Lys Arg Asp Asn Val Leu Phe Gln Ala Ala Thr Asp 
1               5                   10                  15      


Glu Gln Pro Ala Val Ile Lys Thr Leu Glu Lys Leu Val Asn Ile Glu 
            20                  25                  30          


Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala Ala Ala Gly Asn Phe Leu 
        35                  40                  45              


Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr Val Thr Arg Ser Lys Ser 
    50                  55                  60                  


Ala Gly Leu Val Val Gly Asp Asn Ile Val Gly Lys Ile Lys Gly Arg 
65                  70                  75                  80  


Gly Gly Lys Asn Leu Leu Leu Met Ser His Met Asp Thr Val Tyr Leu 
                85                  90                  95      


Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg Val Glu Gly Asp Lys Ala 
            100                 105                 110         


Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly Gly Asn Ala Val Ile Leu 
        115                 120                 125             


His Thr Leu Lys Leu Leu Lys Glu Tyr Gly Val Arg Asp Tyr Gly Thr 
    130                 135                 140                 


Ile Thr Val Leu Phe Asn Thr Asp Glu Glu Lys Gly Ser Phe Gly Ser 
145                 150                 155                 160 


Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu Ala Asp Tyr Val Leu Ser 
                165                 170                 175     


Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys Leu Ser Leu Gly Thr Ser 
            180                 185                 190         


Gly Ile Ala Tyr Val Gln Val Gln Ile Thr Gly Lys Ala Ser His Ala 
        195                 200                 205             


Gly Ala Ala Pro Glu Leu Gly Val Asn Ala Leu Val Glu Ala Ser Asp 
    210                 215                 220                 


Leu Val Leu Arg Thr Met Asn Ile Asp Asp Lys Ala Lys Asn Leu Arg 
225                 230                 235                 240 


Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln Val Ser Asn Ile Ile Pro 
                245                 250                 255     


Ala Ser Ala Thr Leu Asn Ala Asp Val Arg Tyr Ala Arg Asn Glu Asp 
            260                 265                 270         


Phe Asp Ala Ala Met Lys Thr Leu Glu Glu Arg Ala Gln Gln Lys Lys 
        275                 280                 285             


Leu Pro Glu Ala Asp Val Lys Val Ile Val Thr Arg Gly Arg Pro Ala 
    290                 295                 300                 


Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu Val Asp Lys Ala Val Ala 
305                 310                 315                 320 


Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly Val Glu Glu Arg Thr Gly 
                325                 330                 335     


Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu Ser Gly Lys Pro Val Ile 
            340                 345                 350         


Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr His Ser Asp Lys Ala Glu 
        355                 360                 365             


Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg Leu Tyr Met Ala Ala Arg 
    370                 375                 380                 


Leu Ile Met Asp Leu Gly Ala Gly Lys 
385                 390             


<210>  4
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  4
gccctcgcgc aaaaacggga caatgtattg ttccaagcgg ctactgatga acagccagca       60

gtaattaaaa cgcttgaaaa acttgtcaac atcgagaccg ggacagggga tgctgaaggg      120

attgcagccg caggaaactt tcttgaagcc gaactcaaaa accttgggtt taccgtaacg      180

cgctctaagt cagccggttt ggtcgtaggt gacaacattg tgggaaagat caagggacgg      240

ggcggtaaaa acttgctttt gatgtctcat atggatactg tatatcttaa ggggatcctc      300

gcgaaggcgc cctttcgggt ggaaggcgat aaggcatatg gaccagggat agctgacgac      360

aaggggggta acgcggtcat tctccacaca ctgaaacttc ttaaagaata cggtgtgaga      420

gattatggga cgatcactgt actgttcaac accgatgagg aaaagggctc ttttggctct      480

agagatttga ttcaagaaga agcgaaactg gcagactacg tgttgtcctt cgaacccaca      540

tctgctggcg atgagaagct cagtcttgga acctctggga ttgcgtacgt ccaggtccaa      600

ataaccggaa aggcaagcca tgctggagca gccccagaac ttggcgtaaa tgcgctggtg      660

gaggcgagtg atctggtgct ccggaccatg aacatagatg acaaagccaa aaatctgagg      720

tttcaatgga ccatcgctaa agcagggcag gtctctaata tcatcccggc ttcagccact      780

ttgaacgccg atgttaggta cgcccggaat gaagattttg atgccgctat gaaaacattg      840

gaggaacgag cgcagcaaaa aaagctgcca gaagccgatg ttaaagtaat agtaactaga      900

ggacgacccg cgttcaatgc gggcgagggt ggaaagaagt tggtcgataa ggctgttgcg      960

tactataagg aagcgggggg tacgcttgga gttgaggaga ggaccggagg gggcactgac     1020

gcggcgtacg ccgccctctc aggcaagccc gtaattgagt cacttgggct tcctggtttt     1080

ggttatcact cagacaaggc cgagtacgtg gatatatcag ctatccctcg gcgattgtac     1140

atggcggcac gcttgataat ggatttgggg gctggaaagt aa                        1182


<210>  5
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Pro Ser Ile His Arg Thr Ala Ile Ala Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Phe Val Ala Gly Thr Ala Leu Ala Gln Lys Arg Asp Asn Val Leu 
            20                  25                  30          


Phe Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu 
        35                  40                  45              


Lys Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala 
    50                  55                  60                  


Ala Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr 
65                  70                  75                  80  


Val Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val 
                85                  90                  95      


Gly Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His 
            100                 105                 110         


Met Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg 
        115                 120                 125             


Val Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly 
    130                 135                 140                 


Gly Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly 
145                 150                 155                 160 


Val Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu 
                165                 170                 175     


Lys Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu 
            180                 185                 190         


Ala Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys 
        195                 200                 205             


Leu Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Gln Ile Thr 
    210                 215                 220                 


Gly Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala 
225                 230                 235                 240 


Leu Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp 
                245                 250                 255     


Lys Ala Lys Asn Leu Arg Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln 
            260                 265                 270         


Val Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg 
        275                 280                 285             


Tyr Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu 
    290                 295                 300                 


Arg Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val 
305                 310                 315                 320 


Thr Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu 
                325                 330                 335     


Val Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly 
            340                 345                 350         


Val Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu 
        355                 360                 365             


Ser Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr 
    370                 375                 380                 


His Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg 
385                 390                 395                 400 


Leu Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys 
                405                 410                 415 


<210>  6
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  6
atgcgaccga gtatccacag aacagcaata gctgctgtgc ttgcaacagc gtttgtagcg       60

ggcacggccc tcgcgcaaaa acgggacaat gtattgttcc aagcggctac tgatgaacag      120

ccagcagtaa ttaaaacgct tgaaaaactt gtcaacatcg agaccgggac aggggatgct      180

gaagggattg cagccgcagg aaactttctt gaagccgaac tcaaaaacct tgggtttacc      240

gtaacgcgct ctaagtcagc cggtttggtc gtaggtgaca acattgtggg aaagatcaag      300

ggacggggcg gtaaaaactt gcttttgatg tctcatatgg atactgtata tcttaagggg      360

atcctcgcga aggcgccctt tcgggtggaa ggcgataagg catatggacc agggatagct      420

gacgacaagg ggggtaacgc ggtcattctc cacacactga aacttcttaa agaatacggt      480

gtgagagatt atgggacgat cactgtactg ttcaacaccg atgaggaaaa gggctctttt      540

ggctctagag atttgattca agaagaagcg aaactggcag actacgtgtt gtccttcgaa      600

cccacatctg ctggcgatga gaagctcagt cttggaacct ctgggattgc gtacgtccag      660

gtccaaataa ccggaaaggc aagccatgct ggagcagccc cagaacttgg cgtaaatgcg      720

ctggtggagg cgagtgatct ggtgctccgg accatgaaca tagatgacaa agccaaaaat      780

ctgaggtttc aatggaccat cgctaaagca gggcaggtct ctaatatcat cccggcttca      840

gccactttga acgccgatgt taggtacgcc cggaatgaag attttgatgc cgctatgaaa      900

acattggagg aacgagcgca gcaaaaaaag ctgccagaag ccgatgttaa agtaatagta      960

actagaggac gacccgcgtt caatgcgggc gagggtggaa agaagttggt cgataaggct     1020

gttgcgtact ataaggaagc ggggggtacg cttggagttg aggagaggac cggagggggc     1080

actgacgcgg cgtacgccgc cctctcaggc aagcccgtaa ttgagtcact tgggcttcct     1140

ggttttggtt atcactcaga caaggccgag tacgtggata tatcagctat ccctcggcga     1200

ttgtacatgg cggcacgctt gataatggat ttgggggctg gaaagtaa                  1248


<210>  7
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Leu Ala Gln Lys Arg Asp Asn Val Leu Phe 
            20                  25                  30          


Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu Lys 
        35                  40                  45              


Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala Ala 
    50                  55                  60                  


Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr Val 
65                  70                  75                  80  


Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val Gly 
                85                  90                  95      


Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His Met 
            100                 105                 110         


Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg Val 
        115                 120                 125             


Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly Gly 
    130                 135                 140                 


Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly Val 
145                 150                 155                 160 


Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu Lys 
                165                 170                 175     


Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu Ala 
            180                 185                 190         


Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys Leu 
        195                 200                 205             


Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Gln Ile Thr Gly 
    210                 215                 220                 


Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala Leu 
225                 230                 235                 240 


Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp Lys 
                245                 250                 255     


Ala Lys Asn Leu Arg Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln Val 
            260                 265                 270         


Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg Tyr 
        275                 280                 285             


Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu Arg 
    290                 295                 300                 


Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val Thr 
305                 310                 315                 320 


Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu Val 
                325                 330                 335     


Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly Val 
            340                 345                 350         


Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu Ser 
        355                 360                 365             


Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr His 
    370                 375                 380                 


Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg Leu 
385                 390                 395                 400 


Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys Tyr Pro 
                405                 410                 415     


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Leu Tyr Cys Asn His Arg 
            420                 425                 430         


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly 
        435                 440                 445             


Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
    450                 455             


<210>  8
<211>  1377
<212>  DNA
<213>  Homo sapiens

<400>  8
atggccttgc ccgttaccgc actcctgctg ccgctggcgc tgttgctgca cgcagctcga       60

ccggccctcg cgcaaaaacg ggacaatgta ttgttccaag cggctactga tgaacagcca      120

gcagtaatta aaacgcttga aaaacttgtc aacatcgaga ccgggacagg ggatgctgaa      180

gggattgcag ccgcaggaaa ctttcttgaa gccgaactca aaaaccttgg gtttaccgta      240

acgcgctcta agtcagccgg tttggtcgta ggtgacaaca ttgtgggaaa gatcaaggga      300

cggggcggta aaaacttgct tttgatgtct catatggata ctgtatatct taaggggatc      360

ctcgcgaagg cgccctttcg ggtggaaggc gataaggcat atggaccagg gatagctgac      420

gacaaggggg gtaacgcggt cattctccac acactgaaac ttcttaaaga atacggtgtg      480

agagattatg ggacgatcac tgtactgttc aacaccgatg aggaaaaggg ctcttttggc      540

tctagagatt tgattcaaga agaagcgaaa ctggcagact acgtgttgtc cttcgaaccc      600

acatctgctg gcgatgagaa gctcagtctt ggaacctctg ggattgcgta cgtccaggtc      660

caaataaccg gaaaggcaag ccatgctgga gcagccccag aacttggcgt aaatgcgctg      720

gtggaggcga gtgatctggt gctccggacc atgaacatag atgacaaagc caaaaatctg      780

aggtttcaat ggaccatcgc taaagcaggg caggtctcta atatcatccc ggcttcagcc      840

actttgaacg ccgatgttag gtacgcccgg aatgaagatt ttgatgccgc tatgaaaaca      900

ttggaggaac gagcgcagca aaaaaagctg ccagaagccg atgttaaagt aatagtaact      960

agaggacgac ccgcgttcaa tgcgggcgag ggtggaaaga agttggtcga taaggctgtt     1020

gcgtactata aggaagcggg gggtacgctt ggagttgagg agaggaccgg agggggcact     1080

gacgcggcgt acgccgccct ctcaggcaag cccgtaattg agtcacttgg gcttcctggt     1140

tttggttatc actcagacaa ggccgagtac gtggatatat cagctatccc tcggcgattg     1200

tacatggcgg cacgcttgat aatggatttg ggggctggaa agtatcctta tgatgttcca     1260

gactacgcag ggggcggact gtattgtaac caccgaaatc gacggcgagt atgcaagtgc     1320

cctcgaccag ttgttaaatc tggggataaa ccttcactgt ccgctagata cgtgtaa        1377


<210>  9
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Pro Ser Ile His Arg Thr Ala Ile Ala Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Phe Val Ala Gly Thr 
            20          


<210>  10
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  10
atgcgaccga gtatccacag aacagcaata gctgctgtgc ttgcaacagc gtttgtagcg       60

ggcacg                                                                  66


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  12
atggccttgc ccgttaccgc actcctgctg ccgctggcgc tgttgctgca cgcagctcga       60

ccg                                                                     63


<210>  13
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  14
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  14
ctgtattgta accaccgaaa tcgacggcga gtatgcaagt gccctcgacc agttgttaaa       60

tctggggata aaccttcact gtccgctaga tacgtgtaa                              99


<210>  15
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Gly Gly Gly Arg Pro 
1               5                   10                  15      


Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30      


<210>  16
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  16
ctgtattgta accaccgaaa tcgacggcga gtaggaggag gacgaccagt tgttaaatct       60

ggggataaac cttcactgtc cgctagatac gtgtaa                                 96


<210>  17
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  18
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  18
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  19
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  20
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  20
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgg                                                       735


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  22
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  22
ggcggcggcg gatctggagg tggtggctca ggtggcggag gctcc                       45


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210>  24
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
        35                  40                  45              


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
    50                  55                  60                  


Trp Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly 
65                  70                  75                  80  


Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu 
                85                  90                  95      


Gln Asn Leu Tyr Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
            100                 105                 110         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        115                 120                 125             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    130                 135                 140                 


Ser Lys Pro Phe Trp Val Leu Val Trp Gly Gly Val Leu Ala Cys Tyr 
145                 150                 155                 160 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                165                 170                 175     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            180                 185                 190         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        195                 200                 205             


Phe Ala Ala Tyr Arg Ser 
    210                 


<210>  25
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  25
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      120

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      240

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc      300

gacttcgcag cctatcgctc c                                                321


<210>  26
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Trp Lys Ser Gly 
    210                 215                 220                 


Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 


<210>  27
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  28
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  29
<211>  337
<212>  DNA
<213>  Homo sapiens

<400>  29
agagtgaagt tcagcaggag cgcagagccc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgcg                               337


<210>  30
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Gly Thr Lys Glu Arg Asp Trp Cys Gly Pro Ser Pro Ala 
145                 150                 155                 160 


Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg 
                165                 170                 175     


Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr 
            180                 185                 190         


Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser 
        195                 200                 205             


Trp Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250     


<210>  31
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Trp Ser Ser Lys Pro Cys 
65                  70                  75                  80  


Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys Gln 
                85                  90                  95      


Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly Thr 
            100                 105                 110         


Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys Pro 
        115                 120                 125             


Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp Thr 
    130                 135                 140                 


Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn Ser 
145                 150                 155                 160 


Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln 
                165                 170                 175     


Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu 
            180                 185                 190         


Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val 
        195                 200                 205             


Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu 
    210                 215                 220                 


Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg 
225                 230                 235                 240 


Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
                245                 250                 255     


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            260                 265                 270         


Leu Ala Lys Ile 
        275     


<210>  32
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Trp Cys Ile Leu Gly Cys Ile Leu Ile 
145                 150                 155                 160 


Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
                165                 170                 175     


Gly Glu Tyr Met Phe Met Arg Ala Thr Ala Lys Lys Ser Arg Leu Thr 
            180                 185                 190         


Asp Val Thr Leu 
        195     


<210>  33
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Trp Leu Ala Ser 
        35                  40                  45              


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys 
    50                  55                  60                  


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
65                  70                  75                  80  


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe 
                85                  90                  95      


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Leu Thr 
            100                 105                 110         


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
        115                 120                 125             


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
    130                 135                 140                 


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu 
145                 150                 155                 160 


Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe 
                165                 170                 175     


Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro 
            180                 185                 190         


Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys 
        195                 200                 205             


Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220 


<210>  34
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Trp Thr Glu Gly Asp Asn 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Trp Gly Gly Leu Leu 
                165                 170                 175     


Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg 
            180                 185                 190         


Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys 
        195                 200                 205             


Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu 
    210                 215                 220                 


Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val 
225                 230                 235                 240 


Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly 
                245                 250                 255     


Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala 
            260                 265                 270         


Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285     


<210>  35
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Trp Trp 
            20                  25                  30          


Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro 
        35                  40                  45              


Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His 
    50                  55                  60                  


Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala 
65                  70                  75                  80  


Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg 
                85                  90                  95      


Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg 
            100                 105                 110         


Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg 
        115                 120                 125             


Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly 
    130                 135                 140                 


Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg 
145                 150                 155                 160 


Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly 
                165                 170                 175     


Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg 
            180                 185                 190         


Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly 
        195                 200                 205             


Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser Phe 
    210                 215                 220                 


Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys 
225                 230                 235                 240 


Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu 
                245                 250                 255     


Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly 
            260                 265                 270         


Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly 
        275                 280                 285             


Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro 
    290                 295                 300                 


Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu 
305                 310                 315                 320 


Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu 
                325                 330                 335     


Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val 
            340                 345                 350         


Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys 
        355                 360                 365             


Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu 
    370                 375                 380                 


Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln 
385                 390                 395                 400 


Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly 
                405                 410                 415     


Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro 
            420                 425                 430         


Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His 
        435                 440                 445             


Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu Val 
    450                 455                 460                 


Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro Arg 
465                 470                 475                 480 


Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln Ser 
                485                 490                 495     


Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu 
            500                 505                 510         


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 


<210>  36
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Gly Gln Trp Thr Leu Ile Leu Leu Leu Leu Leu Lys Val Tyr 
1               5                   10                  15      


Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Trp Ser Ile Ser Gly 
            20                  25                  30          


Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val Asp Ser 
        35                  40                  45              


Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His His Ile 
    50                  55                  60                  


Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn Asp Arg 
65                  70                  75                  80  


Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala Ala Gln 
                85                  90                  95      


Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile Ser Gly 
            100                 105                 110         


Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser Leu Leu 
        115                 120                 125             


Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu 
    130                 135                 140                 


Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp 
145                 150                 155                 160 


Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr 
                165                 170                 175     


Ala Gly Asn Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr 
            180                 185                 190         


His Thr Tyr Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His 
        195                 200                 205             


Thr Leu Asn Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg 
    210                 215                 220                 


Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu 
225                 230                 235                 240 


Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys 
                245                 250                 255     


Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val 
            260                 265                 270         


Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro 
        275                 280                 285             


Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala 
    290                 295                 300                 


Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro 
305                 310                 315                 320 


Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn 
                325                 330                 335     


Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn 
            340                 345                 350         


Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        355                 360                 365             


<210>  37
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  38
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  39
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  39
atctacatct gggcgcccct ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

acc                                                                     63


<210>  40
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Leu Ala Gln Lys Arg Asp Asn Val Leu Phe 
            20                  25                  30          


Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu Lys 
        35                  40                  45              


Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala Ala 
    50                  55                  60                  


Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr Val 
65                  70                  75                  80  


Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val Gly 
                85                  90                  95      


Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His Met 
            100                 105                 110         


Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg Val 
        115                 120                 125             


Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly Gly 
    130                 135                 140                 


Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly Val 
145                 150                 155                 160 


Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu Lys 
                165                 170                 175     


Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu Ala 
            180                 185                 190         


Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys Leu 
        195                 200                 205             


Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Gln Ile Thr Gly 
    210                 215                 220                 


Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala Leu 
225                 230                 235                 240 


Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp Lys 
                245                 250                 255     


Ala Lys Asn Leu Arg Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln Val 
            260                 265                 270         


Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg Tyr 
        275                 280                 285             


Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu Arg 
    290                 295                 300                 


Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val Thr 
305                 310                 315                 320 


Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu Val 
                325                 330                 335     


Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly Val 
            340                 345                 350         


Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu Ser 
        355                 360                 365             


Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr His 
    370                 375                 380                 


Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg Leu 
385                 390                 395                 400 


Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys Tyr Pro 
                405                 410                 415     


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Ile Tyr Ile Trp Ala Pro 
            420                 425                 430         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        435                 440                 445             


Tyr Cys Asn His Arg Asn Arg Arg Arg Val Gly Gly Gly Arg Pro Val 
    450                 455                 460                 


Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
465                 470                 475             


<210>  41
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  41
atggccttgc ccgttaccgc actcctgctg ccgctggcgc tgttgctgca cgcagctcga       60

ccggccctcg cgcaaaaacg ggacaatgta ttgttccaag cggctactga tgaacagcca      120

gcagtaatta aaacgcttga aaaacttgtc aacatcgaga ccgggacagg ggatgctgaa      180

gggattgcag ccgcaggaaa ctttcttgaa gccgaactca aaaaccttgg gtttaccgta      240

acgcgctcta agtcagccgg tttggtcgta ggtgacaaca ttgtgggaaa gatcaaggga      300

cggggcggta aaaacttgct tttgatgtct catatggata ctgtatatct taaggggatc      360

ctcgcgaagg cgccctttcg ggtggaaggc gataaggcat atggaccagg gatagctgac      420

gacaaggggg gtaacgcggt cattctccac acactgaaac ttcttaaaga atacggtgtg      480

agagattatg ggacgatcac tgtactgttc aacaccgatg aggaaaaggg ctcttttggc      540

tctagagatt tgattcaaga agaagcgaaa ctggcagact acgtgttgtc cttcgaaccc      600

acatctgctg gcgatgagaa gctcagtctt ggaacctctg ggattgcgta cgtccaggtc      660

caaataaccg gaaaggcaag ccatgctgga gcagccccag aacttggcgt aaatgcgctg      720

gtggaggcga gtgatctggt gctccggacc atgaacatag atgacaaagc caaaaatctg      780

aggtttcaat ggaccatcgc taaagcaggg caggtctcta atatcatccc ggcttcagcc      840

actttgaacg ccgatgttag gtacgcccgg aatgaagatt ttgatgccgc tatgaaaaca      900

ttggaggaac gagcgcagca aaaaaagctg ccagaagccg atgttaaagt aatagtaact      960

agaggacgac ccgcgttcaa tgcgggcgag ggtggaaaga agttggtcga taaggctgtt     1020

gcgtactata aggaagcggg gggtacgctt ggagttgagg agaggaccgg agggggcact     1080

gacgcggcgt acgccgccct ctcaggcaag cccgtaattg agtcacttgg gcttcctggt     1140

tttggttatc actcagacaa ggccgagtac gtggatatat cagctatccc tcggcgattg     1200

tacatggcgg cacgcttgat aatggatttg ggggctggaa agtatcctta tgatgttcca     1260

gactacgcag ggggcggaat ctacatctgg gcgcccctgg ccgggacttg tggggtcctt     1320

ctcctgtcac tggttatcac cctgtattgt aaccaccgaa atcgacggcg agtaggagga     1380

ggacgaccag ttgttaaatc tggggataaa ccttcactgt ccgctagata cgtgtaa        1437


<210>  42
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  43
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Met Arg Lys Ser Leu Cys Cys Ala Leu Leu Leu Gly Ile Ser Cys 
1               5                   10                  15      


Ser Ala Leu Ala Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val Val 
            20                  25                  30          


Ala Asn Thr Ile Thr Pro Leu Met Lys Ala Gln Ser Val Pro Gly Met 
        35                  40                  45              


Ala Val Ala Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe Gly 
    50                  55                  60                  


Lys Ala Asp Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu Phe 
65                  70                  75                  80  


Glu Leu Gly Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly Asp 
                85                  90                  95      


Ala Ile Ala Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg Tyr 
            100                 105                 110         


Trp Pro Gln Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu Asp 
        115                 120                 125             


Leu Ala Thr Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp Glu 
    130                 135                 140                 


Val Thr Asp Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln Pro 
145                 150                 155                 160 


Gln Trp Lys Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile Gly 
                165                 170                 175     


Leu Phe Gly Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu Gln 
            180                 185                 190         


Ala Met Thr Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr Trp 
        195                 200                 205             


Ile Asn Val Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr Arg 
    210                 215                 220                 


Asp Gly Lys Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln Ala 
225                 230                 235                 240 


Tyr Gly Val Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met Ala 
                245                 250                 255     


Asn Met Ala Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly Ile 
            260                 265                 270         


Ala Leu Ala Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln Gly 
        275                 280                 285             


Leu Gly Trp Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val Val 
    290                 295                 300                 


Glu Gly Ser Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala Glu 
305                 310                 315                 320 


Val Asn Pro Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys Thr 
                325                 330                 335     


Gly Ser Thr Gly Gly Phe Gly Ser Tyr Val Ala Phe Ile Pro Glu Lys 
            340                 345                 350         


Gln Ile Gly Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro Ala 
        355                 360                 365             


Arg Val Glu Ala Ala Tyr His Ile Leu Glu Ala Leu Gln 
    370                 375                 380     


<210>  44
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val Val Ala Asn Thr Ile 
1               5                   10                  15      


Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly Met Ala Val Ala Val 
            20                  25                  30          


Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe Gly Lys Ala Asp Ile 
        35                  40                  45              


Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu Phe Glu Leu Gly Ser 
    50                  55                  60                  


Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly Asp Ala Ile Ala Arg 
65                  70                  75                  80  


Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg Tyr Trp Pro Gln Leu 
                85                  90                  95      


Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu Asp Leu Ala Thr Tyr 
            100                 105                 110         


Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp Glu Val Thr Asp Asn 
        115                 120                 125             


Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln Pro Gln Trp Lys Pro 
    130                 135                 140                 


Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile Gly Leu Phe Gly Ala 
145                 150                 155                 160 


Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu Gln Ala Met Thr Thr 
                165                 170                 175     


Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr Trp Ile Asn Val Pro 
            180                 185                 190         


Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr Arg Asp Gly Lys Ala 
        195                 200                 205             


Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln Ala Tyr Gly Val Lys 
    210                 215                 220                 


Thr Asn Val Gln Asp Met Ala Asn Trp Val Met Ala Asn Met Ala Pro 
225                 230                 235                 240 


Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly Ile Ala Leu Ala Gln 
                245                 250                 255     


Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln Gly Leu Gly Trp Glu 
            260                 265                 270         


Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val Val Glu Gly Ser Asp 
        275                 280                 285             


Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala Glu Val Asn Pro Pro 
    290                 295                 300                 


Ala Pro Pro Val Lys Ala Ser Trp Val His Lys Thr Gly Ser Thr Gly 
305                 310                 315                 320 


Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu Lys Gln Ile Gly Ile 
                325                 330                 335     


Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro Ala Arg Val Glu Ala 
            340                 345                 350         


Ala Tyr His Ile Leu Glu Ala Leu Gln 
        355                 360     


<210>  45
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Met Arg Lys Ser Leu Cys Cys Ala Leu Leu Leu Gly Ile Ser Cys 
1               5                   10                  15      


Ser Ala Leu Ala Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val Val 
            20                  25                  30          


Ala Asn Thr Ile Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly Met 
        35                  40                  45              


Ala Val Ala Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe Gly 
    50                  55                  60                  


Lys Ala Asp Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu Phe 
65                  70                  75                  80  


Glu Leu Gly Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly Asp 
                85                  90                  95      


Ala Ile Ala Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg Tyr 
            100                 105                 110         


Trp Pro Gln Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu Asp 
        115                 120                 125             


Leu Ala Thr Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp Glu 
    130                 135                 140                 


Val Thr Asp Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln Pro 
145                 150                 155                 160 


Gln Trp Lys Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile Gly 
                165                 170                 175     


Leu Phe Gly Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu Gln 
            180                 185                 190         


Ala Met Thr Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr Trp 
        195                 200                 205             


Ile Asn Val Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr Arg 
    210                 215                 220                 


Asp Gly Lys Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln Ala 
225                 230                 235                 240 


Tyr Gly Val Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met Ala 
                245                 250                 255     


Asn Met Ala Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly Ile 
            260                 265                 270         


Ala Leu Ala Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln Gly 
        275                 280                 285             


Leu Gly Trp Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val Val 
    290                 295                 300                 


Glu Gly Ser Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala Glu 
305                 310                 315                 320 


Val Asn Pro Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys Thr 
                325                 330                 335     


Gly Ser Thr Gly Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu Lys 
            340                 345                 350         


Gln Ile Gly Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro Ala 
        355                 360                 365             


Arg Val Glu Ala Ala Tyr His Ile Leu Glu Ala Leu Gln 
    370                 375                 380     


<210>  46
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val 
            20                  25                  30          


Val Ala Asn Thr Ile Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly 
        35                  40                  45              


Met Ala Val Ala Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe 
    50                  55                  60                  


Gly Lys Ala Asp Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu 
65                  70                  75                  80  


Phe Glu Leu Gly Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly 
                85                  90                  95      


Asp Ala Ile Ala Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg 
            100                 105                 110         


Tyr Trp Pro Gln Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu 
        115                 120                 125             


Asp Leu Ala Thr Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp 
    130                 135                 140                 


Glu Val Thr Asp Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln 
145                 150                 155                 160 


Pro Gln Trp Lys Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile 
                165                 170                 175     


Gly Leu Phe Gly Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu 
            180                 185                 190         


Gln Ala Met Thr Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr 
        195                 200                 205             


Trp Ile Asn Val Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr 
    210                 215                 220                 


Arg Asp Gly Lys Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln 
225                 230                 235                 240 


Ala Tyr Gly Val Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met 
                245                 250                 255     


Ala Asn Met Ala Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly 
            260                 265                 270         


Ile Ala Leu Ala Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln 
        275                 280                 285             


Gly Leu Gly Trp Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val 
    290                 295                 300                 


Val Glu Gly Ser Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala 
305                 310                 315                 320 


Glu Val Asn Pro Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys 
                325                 330                 335     


Thr Gly Ser Thr Gly Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu 
            340                 345                 350         


Lys Gln Ile Gly Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro 
        355                 360                 365             


Ala Arg Val Glu Ala Ala Tyr His Ile Leu Glu Ala Leu Gln Tyr Pro 
    370                 375                 380                 


Tyr Asp Val Pro Asp Tyr Ala 
385                 390     


<210>  47
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val 
            20                  25                  30          


Val Ala Asn Thr Ile Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly 
        35                  40                  45              


Met Ala Val Ala Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe 
    50                  55                  60                  


Gly Lys Ala Asp Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu 
65                  70                  75                  80  


Phe Glu Leu Gly Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly 
                85                  90                  95      


Asp Ala Ile Ala Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg 
            100                 105                 110         


Tyr Trp Pro Gln Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu 
        115                 120                 125             


Asp Leu Ala Thr Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp 
    130                 135                 140                 


Glu Val Thr Asp Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln 
145                 150                 155                 160 


Pro Gln Trp Lys Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile 
                165                 170                 175     


Gly Leu Phe Gly Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu 
            180                 185                 190         


Gln Ala Met Thr Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr 
        195                 200                 205             


Trp Ile Asn Val Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr 
    210                 215                 220                 


Arg Asp Gly Lys Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln 
225                 230                 235                 240 


Ala Tyr Gly Val Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met 
                245                 250                 255     


Ala Asn Met Ala Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly 
            260                 265                 270         


Ile Ala Leu Ala Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln 
        275                 280                 285             


Gly Leu Gly Trp Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val 
    290                 295                 300                 


Val Glu Gly Ser Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala 
305                 310                 315                 320 


Glu Val Asn Pro Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys 
                325                 330                 335     


Thr Gly Ser Thr Gly Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu 
            340                 345                 350         


Lys Gln Ile Gly Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro 
        355                 360                 365             


Ala Arg Val Glu Ala Ala Tyr His Ile Leu Glu Ala Leu Gln Tyr Pro 
    370                 375                 380                 


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Leu Tyr Cys Asn His Arg 
385                 390                 395                 400 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly 
                405                 410                 415     


Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            420                 425     


<210>  48
<211>  970
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Leu Ala Gln Lys Arg Asp Asn Val Leu Phe 
            20                  25                  30          


Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu Lys 
        35                  40                  45              


Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala Ala 
    50                  55                  60                  


Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr Val 
65                  70                  75                  80  


Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val Gly 
                85                  90                  95      


Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His Met 
            100                 105                 110         


Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg Val 
        115                 120                 125             


Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly Gly 
    130                 135                 140                 


Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly Val 
145                 150                 155                 160 


Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu Lys 
                165                 170                 175     


Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu Ala 
            180                 185                 190         


Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys Leu 
        195                 200                 205             


Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Gln Ile Thr Gly 
    210                 215                 220                 


Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala Leu 
225                 230                 235                 240 


Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp Lys 
                245                 250                 255     


Ala Lys Asn Leu Arg Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln Val 
            260                 265                 270         


Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg Tyr 
        275                 280                 285             


Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu Arg 
    290                 295                 300                 


Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val Thr 
305                 310                 315                 320 


Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu Val 
                325                 330                 335     


Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly Val 
            340                 345                 350         


Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu Ser 
        355                 360                 365             


Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr His 
    370                 375                 380                 


Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg Leu 
385                 390                 395                 400 


Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys Tyr Pro 
                405                 410                 415     


Tyr Asp Val Pro Asp Tyr Ala Gly Gly Gly Leu Tyr Cys Asn His Arg 
            420                 425                 430         


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly 
        435                 440                 445             


Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val Gly Ser Gly Ala Thr Asn 
    450                 455                 460                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
465                 470                 475                 480 


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
                485                 490                 495     


Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
            500                 505                 510         


Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser 
        515                 520                 525             


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
    530                 535                 540                 


Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys 
545                 550                 555                 560 


Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
                565                 570                 575     


Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
            580                 585                 590         


Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
625                 630                 635                 640 


Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr 
                645                 650                 655     


Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln 
            660                 665                 670         


Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg 
        675                 680                 685             


Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr 
705                 710                 715                 720 


Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Glu Ile Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala Pro 
            740                 745                 750         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        755                 760                 765             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    770                 775                 780                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
785                 790                 795                 800 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
                805                 810                 815     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            820                 825                 830         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        835                 840                 845             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    850                 855                 860                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
865                 870                 875                 880 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                885                 890                 895     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            900                 905                 910         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        915                 920                 925             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    930                 935                 940                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
945                 950                 955                 960 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                965                 970 


<210>  49
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gln Pro Leu Glu Gly 
                485                 490                 495     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            500                 505                 510         


Glu Asn Pro Gly Pro Met Ala Leu Ala Gln Lys Arg Asp Asn Val Leu 
        515                 520                 525             


Phe Gln Ala Ala Thr Asp Glu Gln Pro Ala Val Ile Lys Thr Leu Glu 
    530                 535                 540                 


Lys Leu Val Asn Ile Glu Thr Gly Thr Gly Asp Ala Glu Gly Ile Ala 
545                 550                 555                 560 


Ala Ala Gly Asn Phe Leu Glu Ala Glu Leu Lys Asn Leu Gly Phe Thr 
                565                 570                 575     


Val Thr Arg Ser Lys Ser Ala Gly Leu Val Val Gly Asp Asn Ile Val 
            580                 585                 590         


Gly Lys Ile Lys Gly Arg Gly Gly Lys Asn Leu Leu Leu Met Ser His 
        595                 600                 605             


Met Asp Thr Val Tyr Leu Lys Gly Ile Leu Ala Lys Ala Pro Phe Arg 
    610                 615                 620                 


Val Glu Gly Asp Lys Ala Tyr Gly Pro Gly Ile Ala Asp Asp Lys Gly 
625                 630                 635                 640 


Gly Asn Ala Val Ile Leu His Thr Leu Lys Leu Leu Lys Glu Tyr Gly 
                645                 650                 655     


Val Arg Asp Tyr Gly Thr Ile Thr Val Leu Phe Asn Thr Asp Glu Glu 
            660                 665                 670         


Lys Gly Ser Phe Gly Ser Arg Asp Leu Ile Gln Glu Glu Ala Lys Leu 
        675                 680                 685             


Ala Asp Tyr Val Leu Ser Phe Glu Pro Thr Ser Ala Gly Asp Glu Lys 
    690                 695                 700                 


Leu Ser Leu Gly Thr Ser Gly Ile Ala Tyr Val Gln Val Gln Ile Thr 
705                 710                 715                 720 


Gly Lys Ala Ser His Ala Gly Ala Ala Pro Glu Leu Gly Val Asn Ala 
                725                 730                 735     


Leu Val Glu Ala Ser Asp Leu Val Leu Arg Thr Met Asn Ile Asp Asp 
            740                 745                 750         


Lys Ala Lys Asn Leu Arg Phe Gln Trp Thr Ile Ala Lys Ala Gly Gln 
        755                 760                 765             


Val Ser Asn Ile Ile Pro Ala Ser Ala Thr Leu Asn Ala Asp Val Arg 
    770                 775                 780                 


Tyr Ala Arg Asn Glu Asp Phe Asp Ala Ala Met Lys Thr Leu Glu Glu 
785                 790                 795                 800 


Arg Ala Gln Gln Lys Lys Leu Pro Glu Ala Asp Val Lys Val Ile Val 
                805                 810                 815     


Thr Arg Gly Arg Pro Ala Phe Asn Ala Gly Glu Gly Gly Lys Lys Leu 
            820                 825                 830         


Val Asp Lys Ala Val Ala Tyr Tyr Lys Glu Ala Gly Gly Thr Leu Gly 
        835                 840                 845             


Val Glu Glu Arg Thr Gly Gly Gly Thr Asp Ala Ala Tyr Ala Ala Leu 
    850                 855                 860                 


Ser Gly Lys Pro Val Ile Glu Ser Leu Gly Leu Pro Gly Phe Gly Tyr 
865                 870                 875                 880 


His Ser Asp Lys Ala Glu Tyr Val Asp Ile Ser Ala Ile Pro Arg Arg 
                885                 890                 895     


Leu Tyr Met Ala Ala Arg Leu Ile Met Asp Leu Gly Ala Gly Lys 
            900                 905                 910     


<210>  50
<211>  880
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val Val Ala Asn Thr 
1               5                   10                  15      


Ile Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly Met Ala Val Ala 
            20                  25                  30          


Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe Gly Lys Ala Asp 
        35                  40                  45              


Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu Phe Glu Leu Gly 
    50                  55                  60                  


Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly Asp Ala Ile Ala 
65                  70                  75                  80  


Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg Tyr Trp Pro Gln 
                85                  90                  95      


Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu Asp Leu Ala Thr 
            100                 105                 110         


Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp Glu Val Thr Asp 
        115                 120                 125             


Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln Pro Gln Trp Lys 
    130                 135                 140                 


Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile Gly Leu Phe Gly 
145                 150                 155                 160 


Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu Gln Ala Met Thr 
                165                 170                 175     


Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr Trp Ile Asn Val 
            180                 185                 190         


Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr Arg Asp Gly Lys 
        195                 200                 205             


Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln Ala Tyr Gly Val 
    210                 215                 220                 


Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met Ala Asn Met Ala 
225                 230                 235                 240 


Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly Ile Ala Leu Ala 
                245                 250                 255     


Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln Gly Leu Gly Trp 
            260                 265                 270         


Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val Val Glu Gly Ser 
        275                 280                 285             


Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala Glu Val Asn Pro 
    290                 295                 300                 


Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys Thr Gly Ser Thr 
305                 310                 315                 320 


Gly Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu Lys Gln Ile Gly 
                325                 330                 335     


Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro Ala Arg Val Glu 
            340                 345                 350         


Ala Ala Tyr His Ile Leu Glu Ala Leu Gln Tyr Pro Tyr Asp Val Pro 
        355                 360                 365             


Asp Tyr Ala Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    370                 375                 380                 


Glu Glu Asn Pro Gly Pro Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Leu His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala 
                405                 410                 415     


Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
            420                 425                 430         


Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
        435                 440                 445             


Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp 
    450                 455                 460                 


Thr Asn Tyr Asn Gly Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp 
465                 470                 475                 480 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu 
                485                 490                 495     


Asp Ser Ala Val Tyr Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val 
            500                 505                 510         


Asp Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
545                 550                 555                 560 


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
                565                 570                 575     


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
            580                 585                 590         


Tyr Ser Ala Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly 
        595                 600                 605             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
    610                 615                 620                 


Lys Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr 
625                 630                 635                 640 


Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Pro 
                645                 650                 655     


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            660                 665                 670         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
        675                 680                 685             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
    690                 695                 700                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
705                 710                 715                 720 


Ile Thr Leu Tyr Cys Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                725                 730                 735     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            740                 745                 750         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        755                 760                 765             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    770                 775                 780                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
785                 790                 795                 800 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                805                 810                 815     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            820                 825                 830         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        835                 840                 845             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    850                 855                 860                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
865                 870                 875                 880 


<210>  51
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gln Pro Leu Glu Gly 
                485                 490                 495     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            500                 505                 510         


Glu Asn Pro Gly Pro Thr Pro Val Ser Glu Lys Gln Leu Ala Glu Val 
        515                 520                 525             


Val Ala Asn Thr Ile Thr Pro Leu Met Ala Ala Gln Ser Val Pro Gly 
    530                 535                 540                 


Met Ala Val Ala Val Ile Tyr Gln Gly Lys Pro His Tyr Tyr Thr Phe 
545                 550                 555                 560 


Gly Lys Ala Asp Ile Ala Ala Asn Lys Pro Val Thr Pro Gln Thr Leu 
                565                 570                 575     


Phe Glu Leu Gly Ser Ile Ser Lys Thr Phe Thr Gly Val Leu Gly Gly 
            580                 585                 590         


Asp Ala Ile Ala Arg Gly Glu Ile Ser Leu Asp Asp Ala Val Thr Arg 
        595                 600                 605             


Tyr Trp Pro Gln Leu Thr Gly Lys Gln Trp Gln Gly Ile Arg Met Leu 
    610                 615                 620                 


Asp Leu Ala Thr Tyr Thr Ala Gly Gly Leu Pro Leu Gln Val Pro Asp 
625                 630                 635                 640 


Glu Val Thr Asp Asn Ala Ser Leu Leu Arg Phe Tyr Gln Asn Trp Gln 
                645                 650                 655     


Pro Gln Trp Lys Pro Gly Thr Thr Arg Leu Tyr Ala Asn Ala Ser Ile 
            660                 665                 670         


Gly Leu Phe Gly Ala Leu Ala Val Lys Pro Ser Gly Met Pro Tyr Glu 
        675                 680                 685             


Gln Ala Met Thr Thr Arg Val Leu Lys Pro Leu Lys Leu Asp His Thr 
    690                 695                 700                 


Trp Ile Asn Val Pro Lys Ala Glu Glu Ala His Tyr Ala Trp Gly Tyr 
705                 710                 715                 720 


Arg Asp Gly Lys Ala Val Arg Val Ser Pro Gly Met Leu Asp Ala Gln 
                725                 730                 735     


Ala Tyr Gly Val Lys Thr Asn Val Gln Asp Met Ala Asn Trp Val Met 
            740                 745                 750         


Ala Asn Met Ala Pro Glu Asn Val Ala Asp Ala Ser Leu Lys Gln Gly 
        755                 760                 765             


Ile Ala Leu Ala Gln Ser Arg Tyr Trp Arg Ile Gly Ser Met Tyr Gln 
    770                 775                 780                 


Gly Leu Gly Trp Glu Met Leu Asn Trp Pro Val Glu Ala Asn Thr Val 
785                 790                 795                 800 


Val Glu Gly Ser Asp Ser Lys Val Ala Leu Ala Pro Leu Pro Val Ala 
                805                 810                 815     


Glu Val Asn Pro Pro Ala Pro Pro Val Lys Ala Ser Trp Val His Lys 
            820                 825                 830         


Thr Gly Ser Thr Gly Gly Phe Gly Ala Tyr Val Ala Phe Ile Pro Glu 
        835                 840                 845             


Lys Gln Ile Gly Ile Val Met Leu Ala Asn Thr Ser Tyr Pro Asn Pro 
    850                 855                 860                 


Ala Arg Val Glu Ala Ala Tyr His Ile Leu Glu Ala Leu Gln Tyr Pro 
865                 870                 875                 880 


Tyr Asp Val Pro Asp Tyr Ala 
                885         


<210>  52
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg 
            260             


<210>  53
<211>  789
<212>  DNA
<213>  Homo sapiens

<400>  53
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacgg                                                              789


