                         SEQUENCE LISTING

<110>  Western University of Health Sciences
 
<120>  Factor IX-Transferrin Fusion Proteins

<130>  029.0050-WO00

<150>  US 62/527,347
<151>  2017-06-30

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  1424
<212>  DNA
<213>  Homo sapiens

<400>  1
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactct cgag                      1424


<210>  2
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  3
<211>  2052
<212>  DNA
<213>  Homo sapiens

<400>  3
ctcgaggtcc ctgataaaac tgtgagatgg tgtgcagtgt cggagcatga ggccactaag       60

tgccagagtt tccgcgacca tatgaaaagc gtcattccat ccgatggtcc cagtgttgct      120

tgtgtgaaga aagcctccta ccttgattgc atcagggcca ttgcggcaaa cgaagcggat      180

gctgtgacac tggatgcagg tttggtgtat gatgcttact tggctcccaa taacctgaag      240

cctgtggtgg cagagttcta tgggtcaaaa gaggatccac agactttcta ttatgctgtt      300

gctgtggtga agaaggatag tggcttccag atgaaccagc ttcgaggcaa gaagtcctgc      360

cacacgggtc taggcaggtc cgctgggtgg aacatcccca taggcttact ttactgtgac      420

ttacctgagc cacgtaaacc tcttgagaaa gcagtggcca atttcttctc gggcagctgt      480

gccccttgtg cggatgggac ggacttcccc cagctgtgtc aactgtgtcc agggtgtggc      540

tgctccaccc ttaaccaata cttcggctac tcgggagcct tcaagtgtct gaaggatggt      600

gctggggatg tggcctttgt caagcactcg actatatttg agaacttggc aaacaaggct      660

gacagggacc agtatgagct gctttgccta gacaacaccc ggaagccggt agatgaatac      720

aaggactgcc acttggccca ggtcccttct cataccgtcg tggcccgaag tatgggcggc      780

aaggaggact tgatctggga gcttctcaac caggcccagg aacattttgg caaagacaaa      840

tcaaaagaat tccaactatt cagctctcct catgggaagg acctgctgtt taaggactct      900

gcccacgggt ttttaaaagt ccccccaagg atggatgcca agatgtacct gggctatgag      960

tatgtcactg ccatccggaa tctacgggaa ggcacatgcc cagaagcccc aacagatgaa     1020

tgcaagcctg tgaagtggtg tgcgctgagc caccacgaga ggctcaagtg tgatgagtgg     1080

agtgttaaca gtgtagggaa aatagagtgt gtatcagcag agaccaccga agactgcatc     1140

gccaagatca tgaatggaga agctgatgcc atgagcttgg atggagggtt tgtctacata     1200

gcgggcaagt gtggtctggt gcctgtcttg gcagaaaact acaataagag cgataattgt     1260

gaggatacac cagaggcagg gtattttgct gtagcagtgg tgaagaaatc agcttctgac     1320

ctcacctggg acaatctgaa aggcaagaag tcctgccata cggcagttgg cagaaccgct     1380

ggctggaaca tccccatggg cctgctctac aataagatca accactgcag atttgatgaa     1440

tttttcagtg aaggttgtgc ccctgggtct aagaaagact ccagtctctg taagctgtgt     1500

atgggctcag gcctaaacct gtgtgaaccc aacaacaaag agggatacta cggctacaca     1560

ggcgctttca ggtgtctggt tgagaaggga gatgtggcct ttgtgaaaca ccagactgtc     1620

ccacagaaca ctgggggaaa aaaccctgat ccatgggcta agaatctgaa tgaaaaagac     1680

tatgagttgc tgtgccttga tggtaccagg aaacctgtgg aggagtatgc gaactgccac     1740

ctggccagag ccccgaatca cgctgtggtc acacggaaag ataaggaagc ttgcgtccac     1800

aagatattac gtcaacagca gcacctattt ggaagcaacg taactgactg ctcgggcaac     1860

ttttgtttgt tccggtcgga aaccaaggac cttctgttca gagatgacac agtatgtttg     1920

gccaaacttc atgacagaaa cacatatgaa aaatacttag gagaagaata tgtcaaggct     1980

gttggtaacc tgagaaaatg ctccacctca tcactcctgg aagcctgcac tttccgtaga     2040

ccttaatcta ga                                                         2052


<210>  4
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala 
1               5                   10                  15      


Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser 
            20                  25                  30          


Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys 
        35                  40                  45              


Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
    50                  55                  60                  


Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val 
65                  70                  75                  80  


Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr 
                85                  90                  95      


Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu 
            100                 105                 110         


Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
        115                 120                 125             


Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys 
    130                 135                 140                 


Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro 
145                 150                 155                 160 


Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly 
                165                 170                 175     


Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe 
            180                 185                 190         


Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser 
        195                 200                 205             


Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu 
    210                 215                 220                 


Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp 
225                 230                 235                 240 


Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Ile 
                245                 250                 255     


Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu 
            260                 265                 270         


His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro 
        275                 280                 285             


His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys 
    290                 295                 300                 


Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val 
305                 310                 315                 320 


Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr 
                325                 330                 335     


Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg 
            340                 345                 350         


Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys 
        355                 360                 365             


Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly 
    370                 375                 380                 


Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly 
385                 390                 395                 400 


Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp 
                405                 410                 415     


Asn Cys Glu Asp Thr Pro Gly Ala Gly Tyr Phe Ala Val Ala Val Val 
            420                 425                 430         


Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys 
        435                 440                 445             


Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met 
    450                 455                 460                 


Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe 
465                 470                 475                 480 


Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys 
                485                 490                 495     


Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu 
            500                 505                 510         


Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
        515                 520                 525             


Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
    530                 535                 540                 


Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
545                 550                 555                 560 


Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
                565                 570                 575     


Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
            580                 585                 590         


Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
        595                 600                 605             


Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
    610                 615                 620                 


Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
625                 630                 635                 640 


Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
                645                 650                 655     


Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
            660                 665                 670         


Ala Cys Thr Phe Arg Arg Pro 
        675                 


<210>  5
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  6
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  7

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  8
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  8

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210>  9
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  9

Ala Gly Cys Lys Asn Phe Phe Pro Arg Ser Phe Thr Ser Cys Gly Ser 
1               5                   10                  15      


<210>  10
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  10

Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro 
1               5                   10                  15      


Asp Val Asp Gly Ser 
            20      


<210>  11
<211>  3500
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  11
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactgg aggaggagga tccggaggag     1440

gaggatccct cgaggtccct gataaaactg tgagatggtg tgcagtgtcg gagcatgagg     1500

ccactaagtg ccagagtttc cgcgaccata tgaaaagcgt cattccatcc gatggtccca     1560

gtgttgcttg tgtgaagaaa gcctcctacc ttgattgcat cagggccatt gcggcaaacg     1620

aagcggatgc tgtgacactg gatgcaggtt tggtgtatga tgcttacttg gctcccaata     1680

acctgaagcc tgtggtggca gagttctatg ggtcaaaaga ggatccacag actttctatt     1740

atgctgttgc tgtggtgaag aaggatagtg gcttccagat gaaccagctt cgaggcaaga     1800

agtcctgcca cacgggtcta ggcaggtccg ctgggtggaa catccccata ggcttacttt     1860

actgtgactt acctgagcca cgtaaacctc ttgagaaagc agtggccaat ttcttctcgg     1920

gcagctgtgc cccttgtgcg gatgggacgg acttccccca gctgtgtcaa ctgtgtccag     1980

ggtgtggctg ctccaccctt aaccaatact tcggctactc gggagccttc aagtgtctga     2040

aggatggtgc tggggatgtg gcctttgtca agcactcgac tatatttgag aacttggcaa     2100

acaaggctga cagggaccag tatgagctgc tttgcctaga caacacccgg aagccggtag     2160

atgaatacaa ggactgccac ttggcccagg tcccttctca taccgtcgtg gcccgaagta     2220

tgggcggcaa ggaggacttg atctgggagc ttctcaacca ggcccaggaa cattttggca     2280

aagacaaatc aaaagaattc caactattca gctctcctca tgggaaggac ctgctgttta     2340

aggactctgc ccacgggttt ttaaaagtcc ccccaaggat ggatgccaag atgtacctgg     2400

gctatgagta tgtcactgcc atccggaatc tacgggaagg cacatgccca gaagccccaa     2460

cagatgaatg caagcctgtg aagtggtgtg cgctgagcca ccacgagagg ctcaagtgtg     2520

atgagtggag tgttaacagt gtagggaaaa tagagtgtgt atcagcagag accaccgaag     2580

actgcatcgc caagatcatg aatggagaag ctgatgccat gagcttggat ggagggtttg     2640

tctacatagc gggcaagtgt ggtctggtgc ctgtcttggc agaaaactac aataagagcg     2700

ataattgtga ggatacacca gaggcagggt attttgctgt agcagtggtg aagaaatcag     2760

cttctgacct cacctgggac aatctgaaag gcaagaagtc ctgccatacg gcagttggca     2820

gaaccgctgg ctggaacatc cccatgggcc tgctctacaa taagatcaac cactgcagat     2880

ttgatgaatt tttcagtgaa ggttgtgccc ctgggtctaa gaaagactcc agtctctgta     2940

agctgtgtat gggctcaggc ctaaacctgt gtgaacccaa caacaaagag ggatactacg     3000

gctacacagg cgctttcagg tgtctggttg agaagggaga tgtggccttt gtgaaacacc     3060

agactgtccc acagaacact gggggaaaaa accctgatcc atgggctaag aatctgaatg     3120

aaaaagacta tgagttgctg tgccttgatg gtaccaggaa acctgtggag gagtatgcga     3180

actgccacct ggccagagcc ccgaatcacg ctgtggtcac acggaaagat aaggaagctt     3240

gcgtccacaa gatattacgt caacagcagc acctatttgg aagcaacgta actgactgct     3300

cgggcaactt ttgtttgttc cggtcggaaa ccaaggacct tctgttcaga gatgacacag     3360

tatgtttggc caaacttcat gacagaaaca catatgaaaa atacttagga gaagaatatg     3420

tcaaggctgt tggtaacctg agaaaatgct ccacctcatc actcctggaa gcctgcactt     3480

tccgtagacc ttaatctaga                                                 3500


<210>  12
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  12

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Pro Asp Lys Thr Val Arg 
465                 470                 475                 480 


Trp Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser Phe Arg 
                485                 490                 495     


Asp His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val Ala Cys 
            500                 505                 510         


Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn 
        515                 520                 525             


Glu Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr 
    530                 535                 540                 


Leu Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr Gly Ser 
545                 550                 555                 560 


Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val Lys Lys 
                565                 570                 575     


Asp Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser Cys His 
            580                 585                 590         


Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu 
        595                 600                 605             


Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala Val Ala 
    610                 615                 620                 


Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe 
625                 630                 635                 640 


Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn 
                645                 650                 655     


Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala 
            660                 665                 670         


Gly Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn Leu Ala 
        675                 680                 685             


Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr 
    690                 695                 700                 


Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln Val Pro 
705                 710                 715                 720 


Ser His Thr Val Val Ala Arg Ser Ile Gly Gly Lys Glu Asp Leu Ile 
                725                 730                 735     


Trp Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp Lys Ser 
            740                 745                 750         


Lys Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu Leu Phe 
        755                 760                 765             


Lys Asp Ser Ala His Gly Phe Leu Lys Val Pro Pro Arg Met Asp Ala 
    770                 775                 780                 


Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg 
785                 790                 795                 800 


Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro Val Lys 
                805                 810                 815     


Trp Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu Trp Ser 
            820                 825                 830         


Val Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr Thr Glu 
        835                 840                 845             


Asp Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met Ser Leu 
    850                 855                 860                 


Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro Val 
865                 870                 875                 880 


Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr Pro Gly 
                885                 890                 895     


Ala Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser Asp Leu 
            900                 905                 910         


Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala Val Gly 
        915                 920                 925             


Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile 
    930                 935                 940                 


Asn His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly 
945                 950                 955                 960 


Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser Gly Leu 
                965                 970                 975     


Asn Leu Cys Glu Pro Asn Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly 
            980                 985                 990         


Ala Phe Arg Cys Leu Val Glu Lys  Gly Asp Val Ala Phe  Val Lys His 
        995                 1000                 1005             


Gln Thr  Val Pro Gln Asn Thr  Gly Gly Lys Asn Pro  Asp Pro Trp 
    1010                 1015                 1020             


Ala Lys  Asn Leu Asn Glu Lys  Asp Tyr Glu Leu Leu  Cys Leu Asp 
    1025                 1030                 1035             


Gly Thr  Arg Lys Pro Val Glu  Glu Tyr Ala Asn Cys  His Leu Ala 
    1040                 1045                 1050             


Arg Ala  Pro Asn His Ala Val  Val Thr Arg Lys Asp  Lys Glu Ala 
    1055                 1060                 1065             


Cys Val  His Lys Ile Leu Arg  Gln Gln Gln His Leu  Phe Gly Ser 
    1070                 1075                 1080             


Asn Val  Thr Asp Cys Ser Gly  Asn Phe Cys Leu Phe  Arg Ser Glu 
    1085                 1090                 1095             


Thr Lys  Asp Leu Leu Phe Arg  Asp Asp Thr Val Cys  Leu Ala Lys 
    1100                 1105                 1110             


Leu His  Asp Arg Asn Thr Tyr  Glu Lys Tyr Leu Gly  Glu Glu Tyr 
    1115                 1120                 1125             


Val Lys  Ala Val Gly Asn Leu  Arg Lys Cys Ser Thr  Ser Ser Leu 
    1130                 1135                 1140             


Leu Glu  Ala Cys Thr Phe Arg  Arg Pro 
    1145                 1150         


<210>  13
<211>  3533
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  13
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactag cgtcagccag actagcaagc     1440

tgacacgagc cgaaaccgtc ttccctgatg tcgacggaag cctcgaggtc cctgataaaa     1500

ctgtgagatg gtgtgcagtg tcggagcatg aggccactaa gtgccagagt ttccgcgacc     1560

atatgaaaag cgtcattcca tccgatggtc ccagtgttgc ttgtgtgaag aaagcctcct     1620

accttgattg catcagggcc attgcggcaa acgaagcgga tgctgtgaca ctggatgcag     1680

gtttggtgta tgatgcttac ttggctccca ataacctgaa gcctgtggtg gcagagttct     1740

atgggtcaaa agaggatcca cagactttct attatgctgt tgctgtggtg aagaaggata     1800

gtggcttcca gatgaaccag cttcgaggca agaagtcctg ccacacgggt ctaggcaggt     1860

ccgctgggtg gaacatcccc ataggcttac tttactgtga cttacctgag ccacgtaaac     1920

ctcttgagaa agcagtggcc aatttcttct cgggcagctg tgccccttgt gcggatggga     1980

cggacttccc ccagctgtgt caactgtgtc cagggtgtgg ctgctccacc cttaaccaat     2040

acttcggcta ctcgggagcc ttcaagtgtc tgaaggatgg tgctggggat gtggcctttg     2100

tcaagcactc gactatattt gagaacttgg caaacaaggc tgacagggac cagtatgagc     2160

tgctttgcct agacaacacc cggaagccgg tagatgaata caaggactgc cacttggccc     2220

aggtcccttc tcataccgtc gtggcccgaa gtatgggcgg caaggaggac ttgatctggg     2280

agcttctcaa ccaggcccag gaacattttg gcaaagacaa atcaaaagaa ttccaactat     2340

tcagctctcc tcatgggaag gacctgctgt ttaaggactc tgcccacggg tttttaaaag     2400

tccccccaag gatggatgcc aagatgtacc tgggctatga gtatgtcact gccatccgga     2460

atctacggga aggcacatgc ccagaagccc caacagatga atgcaagcct gtgaagtggt     2520

gtgcgctgag ccaccacgag aggctcaagt gtgatgagtg gagtgttaac agtgtaggga     2580

aaatagagtg tgtatcagca gagaccaccg aagactgcat cgccaagatc atgaatggag     2640

aagctgatgc catgagcttg gatggagggt ttgtctacat agcgggcaag tgtggtctgg     2700

tgcctgtctt ggcagaaaac tacaataaga gcgataattg tgaggataca ccagaggcag     2760

ggtattttgc tgtagcagtg gtgaagaaat cagcttctga cctcacctgg gacaatctga     2820

aaggcaagaa gtcctgccat acggcagttg gcagaaccgc tggctggaac atccccatgg     2880

gcctgctcta caataagatc aaccactgca gatttgatga atttttcagt gaaggttgtg     2940

cccctgggtc taagaaagac tccagtctct gtaagctgtg tatgggctca ggcctaaacc     3000

tgtgtgaacc caacaacaaa gagggatact acggctacac aggcgctttc aggtgtctgg     3060

ttgagaaggg agatgtggcc tttgtgaaac accagactgt cccacagaac actgggggaa     3120

aaaaccctga tccatgggct aagaatctga atgaaaaaga ctatgagttg ctgtgccttg     3180

atggtaccag gaaacctgtg gaggagtatg cgaactgcca cctggccaga gccccgaatc     3240

acgctgtggt cacacggaaa gataaggaag cttgcgtcca caagatatta cgtcaacagc     3300

agcacctatt tggaagcaac gtaactgact gctcgggcaa cttttgtttg ttccggtcgg     3360

aaaccaagga ccttctgttc agagatgaca cagtatgttt ggccaaactt catgacagaa     3420

acacatatga aaaatactta ggagaagaat atgtcaaggc tgttggtaac ctgagaaaat     3480

gctccacctc atcactcctg gaagcctgca ctttccgtag accttaatct aga            3533


<210>  14
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ser Val Ser 
    450                 455                 460                 


Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp 
465                 470                 475                 480 


Gly Ser Leu Glu Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser 
                485                 490                 495     


Glu His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser 
            500                 505                 510         


Val Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser 
        515                 520                 525             


Tyr Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val 
    530                 535                 540                 


Thr Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn 
545                 550                 555                 560 


Leu Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln 
                565                 570                 575     


Thr Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln 
            580                 585                 590         


Met Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg 
        595                 600                 605             


Ser Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro 
    610                 615                 620                 


Glu Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly 
625                 630                 635                 640 


Ser Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln 
                645                 650                 655     


Leu Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr 
            660                 665                 670         


Ser Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe 
        675                 680                 685             


Val Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg 
    690                 695                 700                 


Asp Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp 
705                 710                 715                 720 


Glu Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val 
                725                 730                 735     


Ala Arg Ser Ile Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn 
            740                 745                 750         


Gln Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu 
        755                 760                 765             


Phe Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His 
    770                 775                 780                 


Gly Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly 
785                 790                 795                 800 


Tyr Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro 
                805                 810                 815     


Glu Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser 
            820                 825                 830         


His His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly 
        835                 840                 845             


Lys Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys 
    850                 855                 860                 


Ile Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val 
865                 870                 875                 880 


Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr 
                885                 890                 895     


Asn Lys Ser Asp Asn Cys Glu Asp Thr Pro Gly Ala Gly Tyr Phe Ala 
            900                 905                 910         


Val Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu 
        915                 920                 925             


Lys Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp 
    930                 935                 940                 


Asn Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe 
945                 950                 955                 960 


Asp Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser 
                965                 970                 975     


Ser Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro 
            980                 985                 990         


Asn Asn Lys Glu Gly Tyr Tyr Gly  Tyr Thr Gly Ala Phe  Arg Cys Leu 
        995                 1000                 1005             


Val Glu  Lys Gly Asp Val Ala  Phe Val Lys His Gln  Thr Val Pro 
    1010                 1015                 1020             


Gln Asn  Thr Gly Gly Lys Asn  Pro Asp Pro Trp Ala  Lys Asn Leu 
    1025                 1030                 1035             


Asn Glu  Lys Asp Tyr Glu Leu  Leu Cys Leu Asp Gly  Thr Arg Lys 
    1040                 1045                 1050             


Pro Val  Glu Glu Tyr Ala Asn  Cys His Leu Ala Arg  Ala Pro Asn 
    1055                 1060                 1065             


His Ala  Val Val Thr Arg Lys  Asp Lys Glu Ala Cys  Val His Lys 
    1070                 1075                 1080             


Ile Leu  Arg Gln Gln Gln His  Leu Phe Gly Ser Asn  Val Thr Asp 
    1085                 1090                 1095             


Cys Ser  Gly Asn Phe Cys Leu  Phe Arg Ser Glu Thr  Lys Asp Leu 
    1100                 1105                 1110             


Leu Phe  Arg Asp Asp Thr Val  Cys Leu Ala Lys Leu  His Asp Arg 
    1115                 1120                 1125             


Asn Thr  Tyr Glu Lys Tyr Leu  Gly Glu Glu Tyr Val  Lys Ala Val 
    1130                 1135                 1140             


Gly Asn  Leu Arg Lys Cys Ser  Thr Ser Ser Leu Leu  Glu Ala Cys 
    1145                 1150                 1155             


Thr Phe  Arg Arg Pro 
    1160             


<210>  15
<211>  3470
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  15
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactct cgaggtccct gataaaactg     1440

tgagatggtg tgcagtgtcg gagcatgagg ccactaagtg ccagagtttc cgcgaccata     1500

tgaaaagcgt cattccatcc gatggtccca gtgttgcttg tgtgaagaaa gcctcctacc     1560

ttgattgcat cagggccatt gcggcaaacg aagcggatgc tgtgacactg gatgcaggtt     1620

tggtgtatga tgcttacttg gctcccaata acctgaagcc tgtggtggca gagttctatg     1680

ggtcaaaaga ggatccacag actttctatt atgctgttgc tgtggtgaag aaggatagtg     1740

gcttccagat gaaccagctt cgaggcaaga agtcctgcca cacgggtcta ggcaggtccg     1800

ctgggtggaa catccccata ggcttacttt actgtgactt acctgagcca cgtaaacctc     1860

ttgagaaagc agtggccaat ttcttctcgg gcagctgtgc cccttgtgcg gatgggacgg     1920

acttccccca gctgtgtcaa ctgtgtccag ggtgtggctg ctccaccctt aaccaatact     1980

tcggctactc gggagccttc aagtgtctga aggatggtgc tggggatgtg gcctttgtca     2040

agcactcgac tatatttgag aacttggcaa acaaggctga cagggaccag tatgagctgc     2100

tttgcctaga caacacccgg aagccggtag atgaatacaa ggactgccac ttggcccagg     2160

tcccttctca taccgtcgtg gcccgaagta tgggcggcaa ggaggacttg atctgggagc     2220

ttctcaacca ggcccaggaa cattttggca aagacaaatc aaaagaattc caactattca     2280

gctctcctca tgggaaggac ctgctgttta aggactctgc ccacgggttt ttaaaagtcc     2340

ccccaaggat ggatgccaag atgtacctgg gctatgagta tgtcactgcc atccggaatc     2400

tacgggaagg cacatgccca gaagccccaa cagatgaatg caagcctgtg aagtggtgtg     2460

cgctgagcca ccacgagagg ctcaagtgtg atgagtggag tgttaacagt gtagggaaaa     2520

tagagtgtgt atcagcagag accaccgaag actgcatcgc caagatcatg aatggagaag     2580

ctgatgccat gagcttggat ggagggtttg tctacatagc gggcaagtgt ggtctggtgc     2640

ctgtcttggc agaaaactac aataagagcg ataattgtga ggatacacca gaggcagggt     2700

attttgctgt agcagtggtg aagaaatcag cttctgacct cacctgggac aatctgaaag     2760

gcaagaagtc ctgccatacg gcagttggca gaaccgctgg ctggaacatc cccatgggcc     2820

tgctctacaa taagatcaac cactgcagat ttgatgaatt tttcagtgaa ggttgtgccc     2880

ctgggtctaa gaaagactcc agtctctgta agctgtgtat gggctcaggc ctaaacctgt     2940

gtgaacccaa caacaaagag ggatactacg gctacacagg cgctttcagg tgtctggttg     3000

agaagggaga tgtggccttt gtgaaacacc agactgtccc acagaacact gggggaaaaa     3060

accctgatcc atgggctaag aatctgaatg aaaaagacta tgagttgctg tgccttgatg     3120

gtaccaggaa acctgtggag gagtatgcga actgccacct ggccagagcc ccgaatcacg     3180

ctgtggtcac acggaaagat aaggaagctt gcgtccacaa gatattacgt caacagcagc     3240

acctatttgg aagcaacgta actgactgct cgggcaactt ttgtttgttc cggtcggaaa     3300

ccaaggacct tctgttcaga gatgacacag tatgtttggc caaacttcat gacagaaaca     3360

catatgaaaa atacttagga gaagaatatg tcaaggctgt tggtaacctg agaaaatgct     3420

ccacctcatc actcctggaa gcctgcactt tccgtagacc ttaatctaga                3470


<210>  16
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  16

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Leu Glu Val 
    450                 455                 460                 


Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr 
465                 470                 475                 480 


Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser Asp 
                485                 490                 495     


Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile 
            500                 505                 510         


Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly 
        515                 520                 525             


Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val 
    530                 535                 540                 


Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala 
545                 550                 555                 560 


Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg 
                565                 570                 575     


Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn 
            580                 585                 590         


Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro 
        595                 600                 605             


Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys 
    610                 615                 620                 


Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys 
625                 630                 635                 640 


Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys 
                645                 650                 655     


Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr 
            660                 665                 670         


Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu 
        675                 680                 685             


Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys 
    690                 695                 700                 


His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Ile Gly 
705                 710                 715                 720 


Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His 
                725                 730                 735     


Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His 
            740                 745                 750         


Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val 
        755                 760                 765             


Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr 
    770                 775                 780                 


Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp 
785                 790                 795                 800 


Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg Leu 
                805                 810                 815     


Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val 
            820                 825                 830         


Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu 
        835                 840                 845             


Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys 
    850                 855                 860                 


Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn 
865                 870                 875                 880 


Cys Glu Asp Thr Pro Gly Ala Gly Tyr Phe Ala Val Ala Val Val Lys 
                885                 890                 895     


Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser 
            900                 905                 910         


Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly 
        915                 920                 925             


Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser 
    930                 935                 940                 


Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu 
945                 950                 955                 960 


Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu Gly 
                965                 970                 975     


Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly Asp 
            980                 985                 990         


Val Ala Phe Val Lys His Gln Thr  Val Pro Gln Asn Thr  Gly Gly Lys 
        995                 1000                 1005             


Asn Pro  Asp Pro Trp Ala Lys  Asn Leu Asn Glu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Leu Leu  Cys Leu Asp Gly Thr  Arg Lys Pro Val Glu  Glu Tyr Ala 
    1025                 1030                 1035             


Asn Cys  His Leu Ala Arg Ala  Pro Asn His Ala Val  Val Thr Arg 
    1040                 1045                 1050             


Lys Asp  Lys Glu Ala Cys Val  His Lys Ile Leu Arg  Gln Gln Gln 
    1055                 1060                 1065             


His Leu  Phe Gly Ser Asn Val  Thr Asp Cys Ser Gly  Asn Phe Cys 
    1070                 1075                 1080             


Leu Phe  Arg Ser Glu Thr Lys  Asp Leu Leu Phe Arg  Asp Asp Thr 
    1085                 1090                 1095             


Val Cys  Leu Ala Lys Leu His  Asp Arg Asn Thr Tyr  Glu Lys Tyr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Tyr Val Lys  Ala Val Gly Asn Leu  Arg Lys Cys 
    1115                 1120                 1125             


Ser Thr  Ser Ser Leu Leu Glu  Ala Cys Thr Phe Arg  Arg Pro 
    1130                 1135                 1140         


<210>  17
<211>  3551
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  17
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactgc cgaggccgcc gccaaggagg     1440

ccgccgccaa ggaggccgcc gccaaggagg ccgccgccaa ggaggccgcc gccaaggccc     1500

tcgaggtccc tgataaaact gtgagatggt gtgcagtgtc ggagcatgag gccactaagt     1560

gccagagttt ccgcgaccat atgaaaagcg tcattccatc cgatggtccc agtgttgctt     1620

gtgtgaagaa agcctcctac cttgattgca tcagggccat tgcggcaaac gaagcggatg     1680

ctgtgacact ggatgcaggt ttggtgtatg atgcttactt ggctcccaat aacctgaagc     1740

ctgtggtggc agagttctat gggtcaaaag aggatccaca gactttctat tatgctgttg     1800

ctgtggtgaa gaaggatagt ggcttccaga tgaaccagct tcgaggcaag aagtcctgcc     1860

acacgggtct aggcaggtcc gctgggtgga acatccccat aggcttactt tactgtgact     1920

tacctgagcc acgtaaacct cttgagaaag cagtggccaa tttcttctcg ggcagctgtg     1980

ccccttgtgc ggatgggacg gacttccccc agctgtgtca actgtgtcca gggtgtggct     2040

gctccaccct taaccaatac ttcggctact cgggagcctt caagtgtctg aaggatggtg     2100

ctggggatgt ggcctttgtc aagcactcga ctatatttga gaacttggca aacaaggctg     2160

acagggacca gtatgagctg ctttgcctag acaacacccg gaagccggta gatgaataca     2220

aggactgcca cttggcccag gtcccttctc ataccgtcgt ggcccgaagt atgggcggca     2280

aggaggactt gatctgggag cttctcaacc aggcccagga acattttggc aaagacaaat     2340

caaaagaatt ccaactattc agctctcctc atgggaagga cctgctgttt aaggactctg     2400

cccacgggtt tttaaaagtc cccccaagga tggatgccaa gatgtacctg ggctatgagt     2460

atgtcactgc catccggaat ctacgggaag gcacatgccc agaagcccca acagatgaat     2520

gcaagcctgt gaagtggtgt gcgctgagcc accacgagag gctcaagtgt gatgagtgga     2580

gtgttaacag tgtagggaaa atagagtgtg tatcagcaga gaccaccgaa gactgcatcg     2640

ccaagatcat gaatggagaa gctgatgcca tgagcttgga tggagggttt gtctacatag     2700

cgggcaagtg tggtctggtg cctgtcttgg cagaaaacta caataagagc gataattgtg     2760

aggatacacc agaggcaggg tattttgctg tagcagtggt gaagaaatca gcttctgacc     2820

tcacctggga caatctgaaa ggcaagaagt cctgccatac ggcagttggc agaaccgctg     2880

gctggaacat ccccatgggc ctgctctaca ataagatcaa ccactgcaga tttgatgaat     2940

ttttcagtga aggttgtgcc cctgggtcta agaaagactc cagtctctgt aagctgtgta     3000

tgggctcagg cctaaacctg tgtgaaccca acaacaaaga gggatactac ggctacacag     3060

gcgctttcag gtgtctggtt gagaagggag atgtggcctt tgtgaaacac cagactgtcc     3120

cacagaacac tgggggaaaa aaccctgatc catgggctaa gaatctgaat gaaaaagact     3180

atgagttgct gtgccttgat ggtaccagga aacctgtgga ggagtatgcg aactgccacc     3240

tggccagagc cccgaatcac gctgtggtca cacggaaaga taaggaagct tgcgtccaca     3300

agatattacg tcaacagcag cacctatttg gaagcaacgt aactgactgc tcgggcaact     3360

tttgtttgtt ccggtcggaa accaaggacc ttctgttcag agatgacaca gtatgtttgg     3420

ccaaacttca tgacagaaac acatatgaaa aatacttagg agaagaatat gtcaaggctg     3480

ttggtaacct gagaaaatgc tccacctcat cactcctgga agcctgcact ttccgtagac     3540

cttaatctag a                                                          3551


<210>  18
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  18

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ala Glu Ala 
    450                 455                 460                 


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
465                 470                 475                 480 


Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu Val Pro Asp Lys Thr Val 
                485                 490                 495     


Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser Phe 
            500                 505                 510         


Arg Asp His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val Ala 
        515                 520                 525             


Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala Ala 
    530                 535                 540                 


Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp Ala 
545                 550                 555                 560 


Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr Gly 
                565                 570                 575     


Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val Lys 
            580                 585                 590         


Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser Cys 
        595                 600                 605             


His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly Leu 
    610                 615                 620                 


Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala Val 
625                 630                 635                 640 


Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr Asp 
                645                 650                 655     


Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr Leu 
            660                 665                 670         


Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp Gly 
        675                 680                 685             


Ala Gly Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn Leu 
    690                 695                 700                 


Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp Asn 
705                 710                 715                 720 


Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln Val 
                725                 730                 735     


Pro Ser His Thr Val Val Ala Arg Ser Ile Gly Gly Lys Glu Asp Leu 
            740                 745                 750         


Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp Lys 
        755                 760                 765             


Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu Leu 
    770                 775                 780                 


Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val Pro Pro Arg Met Asp 
785                 790                 795                 800 


Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn Leu 
                805                 810                 815     


Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro Val 
            820                 825                 830         


Lys Trp Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu Trp 
        835                 840                 845             


Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr Thr 
    850                 855                 860                 


Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met Ser 
865                 870                 875                 880 


Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro 
                885                 890                 895     


Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr Pro 
            900                 905                 910         


Gly Ala Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser Asp 
        915                 920                 925             


Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala Val 
    930                 935                 940                 


Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn Lys 
945                 950                 955                 960 


Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala Pro 
                965                 970                 975     


Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser Gly 
            980                 985                 990         


Leu Asn Leu Cys Glu Pro Asn Asn  Lys Glu Gly Tyr Tyr  Gly Tyr Thr 
        995                 1000                 1005             


Gly Ala  Phe Arg Cys Leu Val  Glu Lys Gly Asp Val  Ala Phe Val 
    1010                 1015                 1020             


Lys His  Gln Thr Val Pro Gln  Asn Thr Gly Gly Lys  Asn Pro Asp 
    1025                 1030                 1035             


Pro Trp  Ala Lys Asn Leu Asn  Glu Lys Asp Tyr Glu  Leu Leu Cys 
    1040                 1045                 1050             


Leu Asp  Gly Thr Arg Lys Pro  Val Glu Glu Tyr Ala  Asn Cys His 
    1055                 1060                 1065             


Leu Ala  Arg Ala Pro Asn His  Ala Val Val Thr Arg  Lys Asp Lys 
    1070                 1075                 1080             


Glu Ala  Cys Val His Lys Ile  Leu Arg Gln Gln Gln  His Leu Phe 
    1085                 1090                 1095             


Gly Ser  Asn Val Thr Asp Cys  Ser Gly Asn Phe Cys  Leu Phe Arg 
    1100                 1105                 1110             


Ser Glu  Thr Lys Asp Leu Leu  Phe Arg Asp Asp Thr  Val Cys Leu 
    1115                 1120                 1125             


Ala Lys  Leu His Asp Arg Asn  Thr Tyr Glu Lys Tyr  Leu Gly Glu 
    1130                 1135                 1140             


Glu Tyr  Val Lys Ala Val Gly  Asn Leu Arg Lys Cys  Ser Thr Ser 
    1145                 1150                 1155             


Ser Leu  Leu Glu Ala Cys Thr  Phe Arg Arg Pro 
    1160                 1165                 


<210>  19
<211>  3506
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  19
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactgc cgaggccgcc gccaaggagg     1440

ccgccgccaa ggccctcgag gtccctgata aaactgtgag atggtgtgca gtgtcggagc     1500

atgaggccac taagtgccag agtttccgcg accatatgaa aagcgtcatt ccatccgatg     1560

gtcccagtgt tgcttgtgtg aagaaagcct cctaccttga ttgcatcagg gccattgcgg     1620

caaacgaagc ggatgctgtg acactggatg caggtttggt gtatgatgct tacttggctc     1680

ccaataacct gaagcctgtg gtggcagagt tctatgggtc aaaagaggat ccacagactt     1740

tctattatgc tgttgctgtg gtgaagaagg atagtggctt ccagatgaac cagcttcgag     1800

gcaagaagtc ctgccacacg ggtctaggca ggtccgctgg gtggaacatc cccataggct     1860

tactttactg tgacttacct gagccacgta aacctcttga gaaagcagtg gccaatttct     1920

tctcgggcag ctgtgcccct tgtgcggatg ggacggactt cccccagctg tgtcaactgt     1980

gtccagggtg tggctgctcc acccttaacc aatacttcgg ctactcggga gccttcaagt     2040

gtctgaagga tggtgctggg gatgtggcct ttgtcaagca ctcgactata tttgagaact     2100

tggcaaacaa ggctgacagg gaccagtatg agctgctttg cctagacaac acccggaagc     2160

cggtagatga atacaaggac tgccacttgg cccaggtccc ttctcatacc gtcgtggccc     2220

gaagtatggg cggcaaggag gacttgatct gggagcttct caaccaggcc caggaacatt     2280

ttggcaaaga caaatcaaaa gaattccaac tattcagctc tcctcatggg aaggacctgc     2340

tgtttaagga ctctgcccac gggtttttaa aagtcccccc aaggatggat gccaagatgt     2400

acctgggcta tgagtatgtc actgccatcc ggaatctacg ggaaggcaca tgcccagaag     2460

ccccaacaga tgaatgcaag cctgtgaagt ggtgtgcgct gagccaccac gagaggctca     2520

agtgtgatga gtggagtgtt aacagtgtag ggaaaataga gtgtgtatca gcagagacca     2580

ccgaagactg catcgccaag atcatgaatg gagaagctga tgccatgagc ttggatggag     2640

ggtttgtcta catagcgggc aagtgtggtc tggtgcctgt cttggcagaa aactacaata     2700

agagcgataa ttgtgaggat acaccagagg cagggtattt tgctgtagca gtggtgaaga     2760

aatcagcttc tgacctcacc tgggacaatc tgaaaggcaa gaagtcctgc catacggcag     2820

ttggcagaac cgctggctgg aacatcccca tgggcctgct ctacaataag atcaaccact     2880

gcagatttga tgaatttttc agtgaaggtt gtgcccctgg gtctaagaaa gactccagtc     2940

tctgtaagct gtgtatgggc tcaggcctaa acctgtgtga acccaacaac aaagagggat     3000

actacggcta cacaggcgct ttcaggtgtc tggttgagaa gggagatgtg gcctttgtga     3060

aacaccagac tgtcccacag aacactgggg gaaaaaaccc tgatccatgg gctaagaatc     3120

tgaatgaaaa agactatgag ttgctgtgcc ttgatggtac caggaaacct gtggaggagt     3180

atgcgaactg ccacctggcc agagccccga atcacgctgt ggtcacacgg aaagataagg     3240

aagcttgcgt ccacaagata ttacgtcaac agcagcacct atttggaagc aacgtaactg     3300

actgctcggg caacttttgt ttgttccggt cggaaaccaa ggaccttctg ttcagagatg     3360

acacagtatg tttggccaaa cttcatgaca gaaacacata tgaaaaatac ttaggagaag     3420

aatatgtcaa ggctgttggt aacctgagaa aatgctccac ctcatcactc ctggaagcct     3480

gcactttccg tagaccttaa tctaga                                          3506


<210>  20
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  20

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ala Glu Ala 
    450                 455                 460                 


Ala Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu Val Pro Asp Lys Thr 
465                 470                 475                 480 


Val Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser 
                485                 490                 495     


Phe Arg Asp His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val 
            500                 505                 510         


Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala 
        515                 520                 525             


Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp 
    530                 535                 540                 


Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr 
545                 550                 555                 560 


Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val 
                565                 570                 575     


Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser 
            580                 585                 590         


Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly 
        595                 600                 605             


Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala 
    610                 615                 620                 


Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr 
625                 630                 635                 640 


Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr 
                645                 650                 655     


Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp 
            660                 665                 670         


Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn 
        675                 680                 685             


Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp 
    690                 695                 700                 


Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln 
705                 710                 715                 720 


Val Pro Ser His Thr Val Val Ala Arg Ser Ile Gly Gly Lys Glu Asp 
                725                 730                 735     


Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp 
            740                 745                 750         


Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu 
        755                 760                 765             


Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val Pro Pro Arg Met 
    770                 775                 780                 


Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn 
785                 790                 795                 800 


Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro 
                805                 810                 815     


Val Lys Trp Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu 
            820                 825                 830         


Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr 
        835                 840                 845             


Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met 
    850                 855                 860                 


Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val 
865                 870                 875                 880 


Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr 
                885                 890                 895     


Pro Gly Ala Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser 
            900                 905                 910         


Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala 
        915                 920                 925             


Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn 
    930                 935                 940                 


Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala 
945                 950                 955                 960 


Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser 
                965                 970                 975     


Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu Gly Tyr Tyr Gly Tyr 
            980                 985                 990         


Thr Gly Ala Phe Arg Cys Leu Val  Glu Lys Gly Asp Val  Ala Phe Val 
        995                 1000                 1005             


Lys His  Gln Thr Val Pro Gln  Asn Thr Gly Gly Lys  Asn Pro Asp 
    1010                 1015                 1020             


Pro Trp  Ala Lys Asn Leu Asn  Glu Lys Asp Tyr Glu  Leu Leu Cys 
    1025                 1030                 1035             


Leu Asp  Gly Thr Arg Lys Pro  Val Glu Glu Tyr Ala  Asn Cys His 
    1040                 1045                 1050             


Leu Ala  Arg Ala Pro Asn His  Ala Val Val Thr Arg  Lys Asp Lys 
    1055                 1060                 1065             


Glu Ala  Cys Val His Lys Ile  Leu Arg Gln Gln Gln  His Leu Phe 
    1070                 1075                 1080             


Gly Ser  Asn Val Thr Asp Cys  Ser Gly Asn Phe Cys  Leu Phe Arg 
    1085                 1090                 1095             


Ser Glu  Thr Lys Asp Leu Leu  Phe Arg Asp Asp Thr  Val Cys Leu 
    1100                 1105                 1110             


Ala Lys  Leu His Asp Arg Asn  Thr Tyr Glu Lys Tyr  Leu Gly Glu 
    1115                 1120                 1125             


Glu Tyr  Val Lys Ala Val Gly  Asn Leu Arg Lys Cys  Ser Thr Ser 
    1130                 1135                 1140             


Ser Leu  Leu Glu Ala Cys Thr  Phe Arg Arg Pro 
    1145                 1150                 


<210>  21
<211>  3545
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  21
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactgg aggaggagga tccggaggag     1440

gaggatccgg aggaggagga tccggaggag gaggatccgg aggaggagga tccctcgagg     1500

tccctgataa aactgtgaga tggtgtgcag tgtcggagca tgaggccact aagtgccaga     1560

gtttccgcga ccatatgaaa agcgtcattc catccgatgg tcccagtgtt gcttgtgtga     1620

agaaagcctc ctaccttgat tgcatcaggg ccattgcggc aaacgaagcg gatgctgtga     1680

cactggatgc aggtttggtg tatgatgctt acttggctcc caataacctg aagcctgtgg     1740

tggcagagtt ctatgggtca aaagaggatc cacagacttt ctattatgct gttgctgtgg     1800

tgaagaagga tagtggcttc cagatgaacc agcttcgagg caagaagtcc tgccacacgg     1860

gtctaggcag gtccgctggg tggaacatcc ccataggctt actttactgt gacttacctg     1920

agccacgtaa acctcttgag aaagcagtgg ccaatttctt ctcgggcagc tgtgcccctt     1980

gtgcggatgg gacggacttc ccccagctgt gtcaactgtg tccagggtgt ggctgctcca     2040

cccttaacca atacttcggc tactcgggag ccttcaagtg tctgaaggat ggtgctgggg     2100

atgtggcctt tgtcaagcac tcgactatat ttgagaactt ggcaaacaag gctgacaggg     2160

accagtatga gctgctttgc ctagacaaca cccggaagcc ggtagatgaa tacaaggact     2220

gccacttggc ccaggtccct tctcataccg tcgtggcccg aagtatgggc ggcaaggagg     2280

acttgatctg ggagcttctc aaccaggccc aggaacattt tggcaaagac aaatcaaaag     2340

aattccaact attcagctct cctcatggga aggacctgct gtttaaggac tctgcccacg     2400

ggtttttaaa agtcccccca aggatggatg ccaagatgta cctgggctat gagtatgtca     2460

ctgccatccg gaatctacgg gaaggcacat gcccagaagc cccaacagat gaatgcaagc     2520

ctgtgaagtg gtgtgcgctg agccaccacg agaggctcaa gtgtgatgag tggagtgtta     2580

acagtgtagg gaaaatagag tgtgtatcag cagagaccac cgaagactgc atcgccaaga     2640

tcatgaatgg agaagctgat gccatgagct tggatggagg gtttgtctac atagcgggca     2700

agtgtggtct ggtgcctgtc ttggcagaaa actacaataa gagcgataat tgtgaggata     2760

caccagaggc agggtatttt gctgtagcag tggtgaagaa atcagcttct gacctcacct     2820

gggacaatct gaaaggcaag aagtcctgcc atacggcagt tggcagaacc gctggctgga     2880

acatccccat gggcctgctc tacaataaga tcaaccactg cagatttgat gaatttttca     2940

gtgaaggttg tgcccctggg tctaagaaag actccagtct ctgtaagctg tgtatgggct     3000

caggcctaaa cctgtgtgaa cccaacaaca aagagggata ctacggctac acaggcgctt     3060

tcaggtgtct ggttgagaag ggagatgtgg cctttgtgaa acaccagact gtcccacaga     3120

acactggggg aaaaaaccct gatccatggg ctaagaatct gaatgaaaaa gactatgagt     3180

tgctgtgcct tgatggtacc aggaaacctg tggaggagta tgcgaactgc cacctggcca     3240

gagccccgaa tcacgctgtg gtcacacgga aagataagga agcttgcgtc cacaagatat     3300

tacgtcaaca gcagcaccta tttggaagca acgtaactga ctgctcgggc aacttttgtt     3360

tgttccggtc ggaaaccaag gaccttctgt tcagagatga cacagtatgt ttggccaaac     3420

ttcatgacag aaacacatat gaaaaatact taggagaaga atatgtcaag gctgttggta     3480

acctgagaaa atgctccacc tcatcactcc tggaagcctg cactttccgt agaccttaat     3540

ctaga                                                                 3545


<210>  22
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  22

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Leu Glu Val Pro Asp Lys Thr Val Arg Trp 
                485                 490                 495     


Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp 
            500                 505                 510         


His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val 
        515                 520                 525             


Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu 
    530                 535                 540                 


Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu 
545                 550                 555                 560 


Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys 
                565                 570                 575     


Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp 
            580                 585                 590         


Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr 
        595                 600                 605             


Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr 
    610                 615                 620                 


Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn 
625                 630                 635                 640 


Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro 
                645                 650                 655     


Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln 
            660                 665                 670         


Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly 
        675                 680                 685             


Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn 
    690                 695                 700                 


Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg 
705                 710                 715                 720 


Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser 
                725                 730                 735     


His Thr Val Val Ala Arg Ser Ile Gly Gly Lys Glu Asp Leu Ile Trp 
            740                 745                 750         


Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys 
        755                 760                 765             


Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys 
    770                 775                 780                 


Asp Ser Ala His Gly Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys 
785                 790                 795                 800 


Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu 
                805                 810                 815     


Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp 
            820                 825                 830         


Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val 
        835                 840                 845             


Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp 
    850                 855                 860                 


Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp 
865                 870                 875                 880 


Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu 
                885                 890                 895     


Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr Pro Gly Ala 
            900                 905                 910         


Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr 
        915                 920                 925             


Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg 
    930                 935                 940                 


Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn 
945                 950                 955                 960 


His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser 
                965                 970                 975     


Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn 
            980                 985                 990         


Leu Cys Glu Pro Asn Asn Lys Glu  Gly Tyr Tyr Gly Tyr  Thr Gly Ala 
        995                 1000                 1005             


Phe Arg  Cys Leu Val Glu Lys  Gly Asp Val Ala Phe  Val Lys His 
    1010                 1015                 1020             


Gln Thr  Val Pro Gln Asn Thr  Gly Gly Lys Asn Pro  Asp Pro Trp 
    1025                 1030                 1035             


Ala Lys  Asn Leu Asn Glu Lys  Asp Tyr Glu Leu Leu  Cys Leu Asp 
    1040                 1045                 1050             


Gly Thr  Arg Lys Pro Val Glu  Glu Tyr Ala Asn Cys  His Leu Ala 
    1055                 1060                 1065             


Arg Ala  Pro Asn His Ala Val  Val Thr Arg Lys Asp  Lys Glu Ala 
    1070                 1075                 1080             


Cys Val  His Lys Ile Leu Arg  Gln Gln Gln His Leu  Phe Gly Ser 
    1085                 1090                 1095             


Asn Val  Thr Asp Cys Ser Gly  Asn Phe Cys Leu Phe  Arg Ser Glu 
    1100                 1105                 1110             


Thr Lys  Asp Leu Leu Phe Arg  Asp Asp Thr Val Cys  Leu Ala Lys 
    1115                 1120                 1125             


Leu His  Asp Arg Asn Thr Tyr  Glu Lys Tyr Leu Gly  Glu Glu Tyr 
    1130                 1135                 1140             


Val Lys  Ala Val Gly Asn Leu  Arg Lys Cys Ser Thr  Ser Ser Leu 
    1145                 1150                 1155             


Leu Glu  Ala Cys Thr Phe Arg  Arg Pro 
    1160                 1165         


<210>  23
<211>  3518
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion

<400>  23
cttaagacca ctttcacaat ctgctagcaa aggttatgca gcgcgtgaac atgatcatgg       60

cagaatcacc aggcctcatc accatctgcc ttttaggata tctactcagt gctgaatgta      120

cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag aggtataatt      180

caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg gaagaaaagt      240

gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact gaattttgga      300

agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc ggcagttgca      360

aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga aagaactgtg      420

aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt aaaaatagtg      480

ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa aaccagaagt      540

cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa acttctaagc      600

tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact gaagctgaaa      660

ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact cgggttgttg      720

gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat ggtaaagttg      780

atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct gcccactgtg      840

ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag gagacagaac      900

atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac aatgcagcta      960

ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta gtgctaaaca     1020

gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc ctcaaatttg     1080

gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca gctttagttc     1140

ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct acaaagttca     1200

ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat tcatgtcaag     1260

gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta actggaatta     1320

ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc aaggtatccc     1380

ggtatgtcaa ctggattaag gaaaaaacaa agctcactgc aggatgtaag aacttcttcc     1440

cacgtagctt cacaagttgc ggtagcctcg aggtccctga taaaactgtg agatggtgtg     1500

cagtgtcgga gcatgaggcc actaagtgcc agagtttccg cgaccatatg aaaagcgtca     1560

ttccatccga tggtcccagt gttgcttgtg tgaagaaagc ctcctacctt gattgcatca     1620

gggccattgc ggcaaacgaa gcggatgctg tgacactgga tgcaggtttg gtgtatgatg     1680

cttacttggc tcccaataac ctgaagcctg tggtggcaga gttctatggg tcaaaagagg     1740

atccacagac tttctattat gctgttgctg tggtgaagaa ggatagtggc ttccagatga     1800

accagcttcg aggcaagaag tcctgccaca cgggtctagg caggtccgct gggtggaaca     1860

tccccatagg cttactttac tgtgacttac ctgagccacg taaacctctt gagaaagcag     1920

tggccaattt cttctcgggc agctgtgccc cttgtgcgga tgggacggac ttcccccagc     1980

tgtgtcaact gtgtccaggg tgtggctgct ccacccttaa ccaatacttc ggctactcgg     2040

gagccttcaa gtgtctgaag gatggtgctg gggatgtggc ctttgtcaag cactcgacta     2100

tatttgagaa cttggcaaac aaggctgaca gggaccagta tgagctgctt tgcctagaca     2160

acacccggaa gccggtagat gaatacaagg actgccactt ggcccaggtc ccttctcata     2220

ccgtcgtggc ccgaagtatg ggcggcaagg aggacttgat ctgggagctt ctcaaccagg     2280

cccaggaaca ttttggcaaa gacaaatcaa aagaattcca actattcagc tctcctcatg     2340

ggaaggacct gctgtttaag gactctgccc acgggttttt aaaagtcccc ccaaggatgg     2400

atgccaagat gtacctgggc tatgagtatg tcactgccat ccggaatcta cgggaaggca     2460

catgcccaga agccccaaca gatgaatgca agcctgtgaa gtggtgtgcg ctgagccacc     2520

acgagaggct caagtgtgat gagtggagtg ttaacagtgt agggaaaata gagtgtgtat     2580

cagcagagac caccgaagac tgcatcgcca agatcatgaa tggagaagct gatgccatga     2640

gcttggatgg agggtttgtc tacatagcgg gcaagtgtgg tctggtgcct gtcttggcag     2700

aaaactacaa taagagcgat aattgtgagg atacaccaga ggcagggtat tttgctgtag     2760

cagtggtgaa gaaatcagct tctgacctca cctgggacaa tctgaaaggc aagaagtcct     2820

gccatacggc agttggcaga accgctggct ggaacatccc catgggcctg ctctacaata     2880

agatcaacca ctgcagattt gatgaatttt tcagtgaagg ttgtgcccct gggtctaaga     2940

aagactccag tctctgtaag ctgtgtatgg gctcaggcct aaacctgtgt gaacccaaca     3000

acaaagaggg atactacggc tacacaggcg ctttcaggtg tctggttgag aagggagatg     3060

tggcctttgt gaaacaccag actgtcccac agaacactgg gggaaaaaac cctgatccat     3120

gggctaagaa tctgaatgaa aaagactatg agttgctgtg ccttgatggt accaggaaac     3180

ctgtggagga gtatgcgaac tgccacctgg ccagagcccc gaatcacgct gtggtcacac     3240

ggaaagataa ggaagcttgc gtccacaaga tattacgtca acagcagcac ctatttggaa     3300

gcaacgtaac tgactgctcg ggcaactttt gtttgttccg gtcggaaacc aaggaccttc     3360

tgttcagaga tgacacagta tgtttggcca aacttcatga cagaaacaca tatgaaaaat     3420

acttaggaga agaatatgtc aaggctgttg gtaacctgag aaaatgctcc acctcatcac     3480

tcctggaagc ctgcactttc cgtagacctt aatctaga                             3518


<210>  24
<211>  1158
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion

<400>  24

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ala Gly Cys 
    450                 455                 460                 


Lys Asn Phe Phe Pro Arg Ser Phe Thr Ser Cys Gly Ser Leu Glu Val 
465                 470                 475                 480 


Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr 
                485                 490                 495     


Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser Asp 
            500                 505                 510         


Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile 
        515                 520                 525             


Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly 
    530                 535                 540                 


Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val 
545                 550                 555                 560 


Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala 
                565                 570                 575     


Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg 
            580                 585                 590         


Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn 
        595                 600                 605             


Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro 
    610                 615                 620                 


Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys 
625                 630                 635                 640 


Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys 
                645                 650                 655     


Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys 
            660                 665                 670         


Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr 
        675                 680                 685             


Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu 
    690                 695                 700                 


Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys 
705                 710                 715                 720 


His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Ile Gly 
                725                 730                 735     


Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His 
            740                 745                 750         


Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His 
        755                 760                 765             


Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val 
    770                 775                 780                 


Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr 
785                 790                 795                 800 


Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp 
                805                 810                 815     


Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg Leu 
            820                 825                 830         


Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val 
        835                 840                 845             


Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu 
    850                 855                 860                 


Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys 
865                 870                 875                 880 


Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn 
                885                 890                 895     


Cys Glu Asp Thr Pro Gly Ala Gly Tyr Phe Ala Val Ala Val Val Lys 
            900                 905                 910         


Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser 
        915                 920                 925             


Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly 
    930                 935                 940                 


Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser 
945                 950                 955                 960 


Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu 
                965                 970                 975     


Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu Gly 
            980                 985                 990         


Tyr Tyr Gly Tyr Thr Gly Ala Phe  Arg Cys Leu Val Glu  Lys Gly Asp 
        995                 1000                 1005             


Val Ala  Phe Val Lys His Gln  Thr Val Pro Gln Asn  Thr Gly Gly 
    1010                 1015                 1020             


Lys Asn  Pro Asp Pro Trp Ala  Lys Asn Leu Asn Glu  Lys Asp Tyr 
    1025                 1030                 1035             


Glu Leu  Leu Cys Leu Asp Gly  Thr Arg Lys Pro Val  Glu Glu Tyr 
    1040                 1045                 1050             


Ala Asn  Cys His Leu Ala Arg  Ala Pro Asn His Ala  Val Val Thr 
    1055                 1060                 1065             


Arg Lys  Asp Lys Glu Ala Cys  Val His Lys Ile Leu  Arg Gln Gln 
    1070                 1075                 1080             


Gln His  Leu Phe Gly Ser Asn  Val Thr Asp Cys Ser  Gly Asn Phe 
    1085                 1090                 1095             


Cys Leu  Phe Arg Ser Glu Thr  Lys Asp Leu Leu Phe  Arg Asp Asp 
    1100                 1105                 1110             


Thr Val  Cys Leu Ala Lys Leu  His Asp Arg Asn Thr  Tyr Glu Lys 
    1115                 1120                 1125             


Tyr Leu  Gly Glu Glu Tyr Val  Lys Ala Val Gly Asn  Leu Arg Lys 
    1130                 1135                 1140             


Cys Ser  Thr Ser Ser Leu Leu  Glu Ala Cys Thr Phe  Arg Arg Pro 
    1145                 1150                 1155             


<210>  25
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  25
accgctcgag gtccctgata aaactgtgag at                                     32


<210>  26
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  26
gtagtctaga ttaaggtcta cggaaagtgc a                                      31


<210>  27
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  27
accgctcgag gtccctgata aaactgtgag at                                     32


<210>  28
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  28
gtagtctaga ttaaggtcta cggaaagtgc a                                      31


<210>  29
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  29
tggaagcagt atgttggtaa gc                                                22


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  30
aacagggata gtaagattgt tcc                                               23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  31
tcctgtcatc tcaccttgct c                                                 21


