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<110>  The University of North Carolina at Chapel Hill
       Hathaway, Nate
       Jian, Jin
       MacDonald, Ian
       Butler, Kyle
 
<120>  HETEROCHROMATIN GENE REPRESSION INHIBITORS

<130>  37571.0009P1

<150>  62/527,560
<151>  2017-06-30

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  134
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  1

Cys Ala Ala Cys Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly Ala Gly 
1               5                   10                  15      


Ala Ala Gly Gly Thr Ala Thr Ala Thr Thr Gly Cys Thr Gly Thr Thr 
            20                  25                  30          


Gly Ala Cys Ala Gly Thr Gly Ala Gly Cys Gly Gly Gly Ala Gly Ala 
        35                  40                  45              


Ala Cys Thr Cys Thr Gly Ala Thr Thr Gly Ala Gly Ala Ala Ala Gly 
    50                  55                  60                  


Thr Ala Gly Thr Gly Ala Ala Gly Cys Cys Ala Cys Ala Gly Ala Thr 
65                  70                  75                  80  


Gly Thr Ala Cys Thr Thr Thr Cys Thr Cys Ala Ala Thr Cys Ala Gly 
                85                  90                  95      


Ala Gly Thr Thr Cys Thr Cys Cys Thr Gly Cys Cys Thr Ala Cys Thr 
            100                 105                 110         


Gly Cys Cys Thr Cys Gly Gly Ala Ala Thr Thr Cys Ala Ala Gly Gly 
        115                 120                 125             


Gly Gly Cys Thr Ala Cys 
    130                 


<210>  2
<211>  134
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  2

Gly Thr Ala Gly Cys Cys Cys Cys Thr Thr Gly Ala Ala Thr Thr Cys 
1               5                   10                  15      


Cys Gly Ala Gly Gly Cys Ala Gly Thr Ala Gly Gly Cys Ala Gly Gly 
            20                  25                  30          


Ala Gly Ala Ala Cys Thr Cys Thr Gly Ala Thr Thr Gly Ala Gly Ala 
        35                  40                  45              


Ala Ala Gly Thr Ala Cys Ala Thr Cys Thr Gly Thr Gly Gly Cys Thr 
    50                  55                  60                  


Thr Cys Ala Cys Thr Ala Cys Thr Thr Thr Cys Thr Cys Ala Ala Thr 
65                  70                  75                  80  


Cys Ala Gly Ala Gly Thr Thr Cys Thr Cys Cys Cys Gly Cys Thr Cys 
                85                  90                  95      


Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Gly Cys Ala Ala Thr Ala 
            100                 105                 110         


Thr Ala Cys Cys Thr Thr Cys Thr Cys Gly Ala Gly Cys Cys Thr Thr 
        115                 120                 125             


Cys Thr Gly Thr Thr Gly 
    130                 


<210>  3
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  3

Cys Ala Ala Cys Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly Ala Gly 
1               5                   10                  15      


Ala Ala Gly Gly Thr Ala Thr Ala Thr Thr Gly Cys Thr Gly Thr Thr 
            20                  25                  30          


Gly Ala Cys Ala Gly Thr Gly Ala Gly Cys Gly Cys Ala Gly Cys Ala 
        35                  40                  45              


Cys Thr Gly Ala Cys Thr Cys Ala Thr Ala Cys Ala Thr Thr Gly Ala 
    50                  55                  60                  


Ala Gly Thr Thr Cys Thr Thr Gly Thr Ala Gly Thr Gly Ala Ala Gly 
65                  70                  75                  80  


Cys Cys Ala Cys Ala Gly Ala Thr Gly Thr Ala Cys Ala Ala Gly Ala 
                85                  90                  95      


Ala Cys Thr Thr Cys Ala Ala Thr Gly Thr Ala Thr Gly Ala Gly Thr 
            100                 105                 110         


Cys Ala Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Thr Ala Cys Thr 
        115                 120                 125             


Gly Cys Cys Thr Cys Gly Gly Ala Ala Thr Thr Cys Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Cys Thr Ala Cys 
145                 150 


<210>  4
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  4

Gly Thr Ala Gly Cys Cys Cys Cys Thr Thr Gly Ala Ala Thr Thr Cys 
1               5                   10                  15      


Cys Gly Ala Gly Gly Cys Ala Gly Thr Ala Gly Gly Cys Ala Cys Ala 
            20                  25                  30          


Gly Cys Ala Cys Thr Gly Ala Cys Thr Cys Ala Thr Ala Cys Ala Thr 
        35                  40                  45              


Thr Gly Ala Ala Gly Thr Thr Cys Thr Thr Gly Thr Ala Cys Ala Thr 
    50                  55                  60                  


Cys Thr Gly Thr Gly Gly Cys Thr Thr Cys Ala Cys Thr Ala Cys Ala 
65                  70                  75                  80  


Ala Gly Ala Ala Cys Thr Thr Cys Ala Ala Thr Gly Thr Ala Thr Gly 
                85                  90                  95      


Ala Gly Thr Cys Ala Gly Thr Gly Cys Thr Gly Cys Gly Cys Thr Cys 
            100                 105                 110         


Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Gly Cys Ala Ala Thr Ala 
        115                 120                 125             


Thr Ala Cys Cys Thr Thr Cys Thr Cys Gly Ala Gly Cys Cys Thr Thr 
    130                 135                 140                 


Cys Thr Gly Thr Thr Gly 
145                 150 


<210>  5
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  5

Cys Ala Ala Cys Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly Ala Gly 
1               5                   10                  15      


Ala Ala Gly Gly Thr Ala Thr Ala Thr Thr Gly Cys Thr Gly Thr Thr 
            20                  25                  30          


Gly Ala Cys Ala Gly Thr Gly Ala Gly Cys Gly Cys Cys Thr Thr Cys 
        35                  40                  45              


Gly Gly Thr Cys Cys Thr Gly Ala Cys Cys Ala Ala Ala Gly Ala Cys 
    50                  55                  60                  


Ala Ala Gly Thr Thr Gly Ala Ala Thr Ala Gly Thr Gly Ala Ala Gly 
65                  70                  75                  80  


Cys Cys Ala Cys Ala Gly Ala Thr Gly Thr Ala Thr Thr Cys Ala Ala 
                85                  90                  95      


Cys Thr Thr Gly Thr Cys Thr Thr Thr Gly Gly Thr Cys Ala Gly Gly 
            100                 105                 110         


Ala Cys Cys Gly Ala Ala Gly Gly Thr Gly Cys Cys Thr Ala Cys Thr 
        115                 120                 125             


Gly Cys Cys Thr Cys Gly Gly Ala Ala Thr Thr Cys Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Cys Thr Ala Cys 
145                 150 


<210>  6
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  6

Gly Thr Ala Gly Cys Cys Cys Cys Thr Thr Gly Ala Ala Thr Thr Cys 
1               5                   10                  15      


Cys Gly Ala Gly Gly Cys Ala Gly Thr Ala Gly Gly Cys Ala Cys Cys 
            20                  25                  30          


Thr Thr Cys Gly Gly Thr Cys Cys Thr Gly Ala Cys Cys Ala Ala Ala 
        35                  40                  45              


Gly Ala Cys Ala Ala Gly Thr Thr Gly Ala Ala Thr Ala Cys Ala Thr 
    50                  55                  60                  


Cys Thr Gly Thr Gly Gly Cys Thr Thr Cys Ala Cys Thr Ala Thr Thr 
65                  70                  75                  80  


Cys Ala Ala Cys Thr Thr Gly Thr Cys Thr Thr Thr Gly Gly Thr Cys 
                85                  90                  95      


Ala Gly Gly Ala Cys Cys Gly Ala Ala Gly Gly Cys Gly Cys Thr Cys 
            100                 105                 110         


Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Gly Cys Ala Ala Thr Ala 
        115                 120                 125             


Thr Ala Cys Cys Thr Thr Cys Thr Cys Gly Ala Gly Cys Cys Thr Thr 
    130                 135                 140                 


Cys Thr Gly Thr Thr Gly 
145                 150 


<210>  7
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  7

Cys Ala Ala Cys Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly Ala Gly 
1               5                   10                  15      


Ala Ala Gly Gly Thr Ala Thr Ala Thr Thr Gly Cys Thr Gly Thr Thr 
            20                  25                  30          


Gly Ala Cys Ala Gly Thr Gly Ala Gly Cys Gly Ala Ala Gly Thr Ala 
        35                  40                  45              


Gly Ala Cys Cys Gly Cys Ala Thr Cys Ala Gly Thr Gly Ala Ala Thr 
    50                  55                  60                  


Gly Gly Ala Ala Gly Ala Gly Ala Thr Ala Gly Thr Gly Ala Ala Gly 
65                  70                  75                  80  


Cys Cys Ala Cys Ala Gly Ala Thr Gly Thr Ala Thr Cys Thr Cys Thr 
                85                  90                  95      


Thr Cys Cys Ala Thr Thr Cys Ala Cys Thr Gly Ala Thr Gly Cys Gly 
            100                 105                 110         


Gly Thr Cys Thr Ala Cys Thr Thr Thr Gly Cys Cys Thr Ala Cys Thr 
        115                 120                 125             


Gly Cys Cys Thr Cys Gly Gly Ala Ala Thr Thr Cys Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Cys Thr Ala Cys 
145                 150 


<210>  8
<211>  150
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  8

Gly Thr Ala Gly Cys Cys Cys Cys Thr Thr Gly Ala Ala Thr Thr Cys 
1               5                   10                  15      


Cys Gly Ala Gly Gly Cys Ala Gly Thr Ala Gly Gly Cys Ala Ala Ala 
            20                  25                  30          


Gly Thr Ala Gly Ala Cys Cys Gly Cys Ala Thr Cys Ala Gly Thr Gly 
        35                  40                  45              


Ala Ala Thr Gly Gly Ala Ala Gly Ala Gly Ala Thr Ala Cys Ala Thr 
    50                  55                  60                  


Cys Thr Gly Thr Gly Gly Cys Thr Thr Cys Ala Cys Thr Ala Thr Cys 
65                  70                  75                  80  


Thr Cys Thr Thr Cys Cys Ala Thr Thr Cys Ala Cys Thr Gly Ala Thr 
                85                  90                  95      


Gly Cys Gly Gly Thr Cys Thr Ala Cys Thr Thr Cys Gly Cys Thr Cys 
            100                 105                 110         


Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Gly Cys Ala Ala Thr Ala 
        115                 120                 125             


Thr Ala Cys Cys Thr Thr Cys Thr Cys Gly Ala Gly Cys Cys Thr Thr 
    130                 135                 140                 


Cys Thr Gly Thr Thr Gly 
145                 150 


<210>  9
<211>  19
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  9

Cys Thr Cys Cys Thr Ala Thr Gly Thr Gly Gly Gly Thr Gly Ala Cys 
1               5                   10                  15      


Gly Ala Gly 
            


<210>  10
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  10

Thr Cys Thr Cys Ala Ala Ala Cys Ala Thr Gly Ala Thr Cys Thr Gly 
1               5                   10                  15      


Gly Gly Thr Cys 
            20  


<210>  11
<211>  22
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  11

Cys Ala Ala Gly Cys Thr Gly Gly Ala Gly Thr Ala Cys Ala Ala Cys 
1               5                   10                  15      


Thr Ala Cys Ala Ala Cys 
            20          


<210>  12
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  12

Ala Gly Thr Thr Cys Ala Cys Cys Thr Thr Gly Ala Thr Gly Cys Cys 
1               5                   10                  15      


Gly Thr Thr Cys 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  13

Ala Thr Gly Cys Cys Cys Cys Thr Cys Ala Gly Cys Thr Ala Thr Cys 
1               5                   10                  15      


Ala Cys Ala Cys 
            20  


<210>  14
<211>  21
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  14

Thr Thr Gly Thr Cys Cys Ala Thr Thr Cys Thr Cys Thr Cys Cys Thr 
1               5                   10                  15      


Thr Thr Thr Cys Cys 
            20      


<210>  15
<211>  19
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  15

Cys Cys Ala Thr Thr Gly Thr Gly Gly Gly Ala Ala Cys Ala Ala Cys 
1               5                   10                  15      


Cys Ala Gly 
            


<210>  16
<211>  22
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  16

Thr Ala Gly Ala Gly Gly Ala Thr Cys Thr Cys Gly Ala Thr Thr Cys 
1               5                   10                  15      


Ala Gly Thr Thr Cys Cys 
            20          


<210>  17
<211>  21
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  17

Gly Gly Ala Cys Cys Gly Ala Ala Ala Gly Ala Ala Ala Thr Thr Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala 
            20      


<210>  18
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  18

Cys Ala Gly Gly Cys Ala Cys Ala Gly Ala Thr Gly Ala Ala Gly Thr 
1               5                   10                  15      


Ala Ala Gly Gly 
            20  


<210>  19
<211>  19
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  19

Cys Cys Cys Ala Ala Cys Thr Ala Cys Thr Cys Ala Cys Cys Gly Thr 
1               5                   10                  15      


Cys Thr Cys 
            


<210>  20
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  20

Cys Ala Gly Gly Gly Ala Ala Gly Ala Thr Gly Gly Ala Cys Thr Thr 
1               5                   10                  15      


Cys Cys Thr Gly 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  artificial construct

<220>
<223>  synthetic construct

<400>  21

Ala Gly Ala Gly Cys Gly Ala Thr Thr Cys Thr Gly Ala Cys Thr Cys 
1               5                   10                  15      


Thr Gly Ala Cys 
            20  


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Construct

<220>
<223>  synthetic construct

<400>  22

Thr Ala Gly Ala Gly Ala Cys Thr Gly Ala Cys Ala Cys Cys Thr Thr 
1               5                   10                  15      


Cys Ala Ala Gly Ala Cys 
            20          


