                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc
       THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR CD33 AND METHODS OF 
       THEIR USE

<130>  42449-0027WO1

<150>  US 62/527,165
<151>  2017-06-30

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-9 VH domain

<400>  1
caggtgcagc tggtgcaatc tggggcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggatt cagttttccc acctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagactagtt      300

ggagatggct acaatacggg ggcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-9 VH domain

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Pro Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Asp Gly Tyr Asn Thr Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-9 VL domain

<400>  3
gatattgtga tgacccacac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtaatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ctcctgatct atggagcttc caaccggttc      180

tctggagtgc cagacaggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acagcttcct      300

atcaccttcg gccaagggac acgactggag attaaa                                336


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-9 VH domain

<400>  4

Asp Ile Val Met Thr His Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-10 VH domain

<400>  5
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacactg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtccctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagaaacgt attactatgg ttcggggagt tattgggatg cttttgatat ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210>  6
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-10 VH domain

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Thr Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Pro Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Thr Tyr Tyr Tyr Gly Ser Gly Ser Tyr Trp 
            100                 105                 110         


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  7
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-10 VL domain

<400>  7
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggcacgg cccccaaact cttcatctat aaaaataatc agcggccctc agaggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgacgatg aggctgacta ctactgtgca gcatgggatg acaggctgaa tggatatgtc      300

ttcggaactg ggaccaaggt caccgtccta                                       330


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-10 VH domain

<400>  8

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Phe 
        35                  40                  45              


Ile Tyr Lys Asn Asn Gln Arg Pro Ser Glu Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-12 VH domain

<400>  9
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggagggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataattatca acgcagacac atcgaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgcg      300

aggggatatt actatgatag taccgactgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  10
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-12 VH domain

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Gly Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Ile Ile Asn Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Tyr Tyr Tyr Asp Ser Thr Asp Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-12 VL domain

<400>  11
tcttctgagc tgactcagga cccaactgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg ttcctcccgg gacggcagtg gtcatccata tctcttcgga      300

cctgggacca aggtcaccgt tctt                                             324


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-12 VH domain

<400>  12

Ser Ser Glu Leu Thr Gln Asp Pro Thr Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Gly Ser Gly His Pro 
                85                  90                  95      


Tyr Leu Phe Gly Pro Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  13
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-15 VH domain

<400>  13
gaggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagactgact      300

acggctgggg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210>  14
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-15 VH domain

<400>  14

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Thr Ala Gly Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  15
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m1033-15 VL domain

<400>  15
gaaattgtgc tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta cacagtgatg gaaacaccta cttgagttgg      120

cttcaccaga ggccaggcca gcctccaaga ctcctaatgt ataagatttc taaccggttc      180

tctggggtca cagacagatt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat acacctaccg      300

ctcactttcg gcggagggac caagctggag atcaaa                                336


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1033-15 VH domain

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu His Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Met Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Thr 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  single domain antibody m1033-2

<400>  17
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgagctgggt ccgccaggct      120

ccaaggaagg gcctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc cgaggacaca gccacgtatt actgtgcgag acccctcaac      300

tactactact actacatgga cgtctggggc aaagggacca cggtcaccgt ctcctca         357


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single domain antibody m1033-2

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Arg Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Pro Leu Asn Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  single domain antibody m1033-4

<400>  19
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgagctgggt ccgccaggct      120

ccaagacaag ggcttgagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gcggactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acagccacgt attactgtgc gaaagaaaat      300

gtggactggg gccagggcac cctggtcacc gtctcctca                             339


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single domain antibody m1033-4

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Arg Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asn Val Asp Trp Gly Gln Gly Thr Leu Val Ser Ser 
            100                 105                 110     


