                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Mujica, Alejo
       Gusarova, Viktoria
       Wang, Cheng
       Kyratsous, Christos
       Potocky, Terra
       Cygnar, Katherine
       Martin, Joel
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED ASGR1 LOCUS

<130>  009108.362WO1

<150>  62/525,524
<151>  2017-06-27

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  291
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  Cytoplasmic Domain

<220>
<221>  MISC_FEATURE
<222>  (41)..(61)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (61)..(123)
<223>  Coiled-Coil Domain

<220>
<221>  MISC_FEATURE
<222>  (161)..(278)
<223>  C-Type Lectin Domain

<400>  1

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu Asp Asn Glu Glu Ser 
1               5                   10                  15      


Asp His His Gln Leu Arg Lys Gly Pro Pro Pro Pro Gln Pro Leu Leu 
            20                  25                  30          


Gln Arg Leu Cys Ser Gly Pro Arg Leu Leu Leu Leu Ser Leu Gly Leu 
        35                  40                  45              


Ser Leu Leu Leu Leu Val Val Val Cys Val Ile Gly Ser Gln Asn Ser 
    50                  55                  60                  


Gln Leu Gln Glu Glu Leu Arg Gly Leu Arg Glu Thr Phe Ser Asn Phe 
65                  70                  75                  80  


Thr Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser Thr Gln Gly Gly 
                85                  90                  95      


Asn Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln Leu Glu Lys Gln 
            100                 105                 110         


Gln Lys Asp Leu Ser Glu Asp His Ser Ser Leu Leu Leu His Val Lys 
        115                 120                 125             


Gln Phe Val Ser Asp Leu Arg Ser Leu Ser Cys Gln Met Ala Ala Leu 
    130                 135                 140                 


Gln Gly Asn Gly Ser Glu Arg Thr Cys Cys Pro Val Asn Trp Val Glu 
145                 150                 155                 160 


His Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala Trp Ala 
                165                 170                 175     


Asp Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val Val Val 
            180                 185                 190         


Thr Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly Pro Val 
        195                 200                 205             


Asn Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys Trp Val 
    210                 215                 220                 


Asp Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Glu Gln 
225                 230                 235                 240 


Pro Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala 
                245                 250                 255     


His Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro 
            260                 265                 270         


Tyr Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala Ser Gln Glu Pro 
        275                 280                 285             


Pro Leu Leu 
    290     


<210>  2
<211>  284
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  Cytoplasmic Domain

<220>
<221>  MISC_FEATURE
<222>  (40)..(60)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (60)..(122)
<223>  Coiled-Coil Domain

<220>
<221>  MISC_FEATURE
<222>  (160)..(277)
<223>  C-Type Lectin Domain

<400>  2

Met Thr Lys Asp Tyr Gln Asp Phe Gln His Leu Asp Asn Asp Asn Asp 
1               5                   10                  15      


His His Gln Leu Arg Arg Gly Pro Pro Pro Thr Pro Arg Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Ser Arg Leu Leu Leu Leu Ser Ser Ser Leu Ser 
        35                  40                  45              


Ile Leu Leu Leu Val Val Val Cys Val Ile Thr Ser Gln Asn Ser Gln 
    50                  55                  60                  


Leu Arg Glu Asp Leu Leu Ala Leu Arg Gln Asn Phe Ser Asn Leu Thr 
65                  70                  75                  80  


Val Ser Thr Glu Asp Gln Val Lys Ala Leu Ser Thr Gln Gly Ser Ser 
                85                  90                  95      


Val Gly Arg Lys Met Lys Leu Val Glu Ser Lys Leu Glu Lys Gln Gln 
            100                 105                 110         


Lys Asp Leu Thr Glu Asp His Ser Ser Leu Leu Leu His Val Lys Gln 
        115                 120                 125             


Leu Val Ser Asp Val Arg Ser Leu Ser Cys Gln Met Ala Ala Phe Arg 
    130                 135                 140                 


Gly Asn Gly Ser Glu Arg Thr Cys Cys Pro Ile Asn Trp Val Glu Tyr 
145                 150                 155                 160 


Glu Gly Ser Cys Tyr Trp Phe Ser Ser Ser Val Arg Pro Trp Thr Glu 
                165                 170                 175     


Ala Asp Lys Tyr Cys Gln Leu Glu Asn Ala His Leu Val Val Val Thr 
            180                 185                 190         


Ser Arg Asp Glu Gln Asn Phe Leu Gln Arg His Met Gly Pro Leu Asn 
        195                 200                 205             


Thr Trp Ile Gly Leu Thr Asp Gln Asn Gly Pro Trp Lys Trp Val Asp 
    210                 215                 220                 


Gly Thr Asp Tyr Glu Thr Gly Phe Gln Asn Trp Arg Pro Glu Gln Pro 
225                 230                 235                 240 


Asp Asn Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His 
                245                 250                 255     


Phe Thr Thr Asp Gly Arg Trp Asn Asp Asp Val Cys Arg Arg Pro Tyr 
            260                 265                 270         


Arg Trp Val Cys Glu Thr Lys Leu Asp Lys Ala Asn 
        275                 280                 


<210>  3
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  Cytoplasmic Domain

<220>
<221>  MISC_FEATURE
<222>  (40)..(60)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (60)..(122)
<223>  Coiled-Coil Domain

<220>
<221>  MISC_FEATURE
<222>  (62)..(290)
<223>  Residues Encoded by Introduced Human Exons

<220>
<221>  MISC_FEATURE
<222>  (160)..(277)
<223>  C-Type Lectin Domain

<400>  3

Met Thr Lys Asp Tyr Gln Asp Phe Gln His Leu Asp Asn Asp Asn Asp 
1               5                   10                  15      


His His Gln Leu Arg Arg Gly Pro Pro Pro Thr Pro Arg Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Ser Arg Leu Leu Leu Leu Ser Ser Ser Leu Ser 
        35                  40                  45              


Ile Leu Leu Leu Val Val Val Cys Val Ile Thr Ser Gln Asn Ser Gln 
    50                  55                  60                  


Leu Gln Glu Glu Leu Arg Gly Leu Arg Glu Thr Phe Ser Asn Phe Thr 
65                  70                  75                  80  


Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser Thr Gln Gly Gly Asn 
                85                  90                  95      


Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln Leu Glu Lys Gln Gln 
            100                 105                 110         


Lys Asp Leu Ser Glu Asp His Ser Ser Leu Leu Leu His Val Lys Gln 
        115                 120                 125             


Phe Val Ser Asp Leu Arg Ser Leu Ser Cys Gln Met Ala Ala Leu Gln 
    130                 135                 140                 


Gly Asn Gly Ser Glu Arg Thr Cys Cys Pro Val Asn Trp Val Glu His 
145                 150                 155                 160 


Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala Trp Ala Asp 
                165                 170                 175     


Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val Val Val Thr 
            180                 185                 190         


Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly Pro Val Asn 
        195                 200                 205             


Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys Trp Val Asp 
    210                 215                 220                 


Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Glu Gln Pro 
225                 230                 235                 240 


Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His 
                245                 250                 255     


Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro Tyr 
            260                 265                 270         


Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala Ser Gln Glu Pro Pro 
        275                 280                 285             


Leu Leu 
    290 


<210>  4
<211>  855
<212>  DNA
<213>  Mus musculus

<400>  4
atgacaaagg attatcaaga tttccagcac ctggacaatg ataatgacca tcatcaactc       60

cggagagggc cgcctcccac tccacggctc ttgcagcgac tctgctctgg atcccgcctc      120

ctcctgctct cctcgagcct cagcattctg ttgctggtgg ttgtctgtgt gatcacatcc      180

caaaattccc aactccggga agatctgctg gctctaaggc agaatttcag caacctcact      240

gtgagcactg aggaccaggt caaggccctg agcacccagg gaagtagtgt gggaagaaag      300

atgaagttag tggagtcgaa gctggaaaaa cagcagaagg atctgactga agatcactcc      360

agtttgctac tgcacgtgaa gcagttagtg tctgacgtgc gaagcttgag ctgccagatg      420

gctgcatttc ggggcaatgg ctctgaaagg acctgctgcc ccatcaactg ggtggagtat      480

gaaggcagct gctactggtt ctccagctct gtgaggcctt ggactgaagc tgacaagtac      540

tgccagctgg aaaatgccca tctggtggtg gtgacctcca gggatgagca gaacttcctc      600

cagcgccaca tgggcccctt aaacacttgg attggcctaa ctgaccagaa cgggccctgg      660

aaatgggtgg atggaacaga ctacgagaca ggcttccaga attggagacc agagcagcca      720

gataactggt acggacatgg gcttggagga ggcgaggact gtgcccactt cacgacggat      780

ggccgctgga atgacgacgt ctgcaggagg ccctaccgct gggtctgtga gacaaagttg      840

gataaggcta attag                                                       855


<210>  5
<211>  876
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaccaagg agtatcaaga ccttcagcat ctggacaatg aggagagtga ccaccatcag       60

ctcagaaaag ggccacctcc tccccagccc ctcctgcagc gtctctgctc cggacctcgc      120

ctcctcctgc tctccctggg cctcagcctc ctgctgcttg tggttgtctg tgtgatcgga      180

tcccaaaact cccagctgca ggaggagctg cggggcctga gagagacgtt cagcaacttc      240

acagcgagca cggaggccca ggtcaagggc ttgagcaccc agggaggcaa tgtgggaaga      300

aagatgaagt cgctagagtc ccagctggag aaacagcaga aggacctgag tgaagatcac      360

tccagcctgc tgctccacgt gaagcagttc gtgtctgacc tgcggagcct gagctgtcag      420

atggcggcgc tccagggcaa tggctcagaa aggacctgct gcccggtcaa ctgggtggag      480

cacgagcgca gctgctactg gttctctcgc tccgggaagg cctgggctga cgccgacaac      540

tactgccggc tggaggacgc gcacctggtg gtggtcacgt cctgggagga gcagaaattt      600

gtccagcacc acataggccc tgtgaacacc tggatgggcc tccacgacca aaacgggccc      660

tggaagtggg tggacgggac ggactacgag acgggcttca agaactggag gccggagcag      720

ccggacgact ggtacggcca cgggctcgga ggaggcgagg actgtgccca cttcaccgac      780

gacggccgct ggaacgacga cgtctgccag aggccctacc gctgggtctg cgagacagag      840

ctggacaagg ccagccagga gccacctctc ctttaa                                876


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
tcccaactcc gggaagatc                                                    19


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
tgctggctct aaggcagaat ttca                                              24


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
tcagtgctca cagtgaggtt                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gggttggctc atgttaggaa gg                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
tcagcagccg agctgtgaaa                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
caggctgtgc tacccaaagt tc                                                22


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ggaggcaatg tgggaagaaa g                                                 21


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
tgaagtcgct agagtcccag ctgg                                              24


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
tcaggtcctt ctgctgtttc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gattgggaat ccgcccatct                                                   20


<210>  16
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
cctcttctgc tttctcggga attttcatc                                         29


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
aaagcgccac gggtttcaag                                                   20


<210>  18
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (61)..(120)
<223>  Human Sequence

<400>  18
catcccaaag tgggtggcca gggctgggca gagaaagggg gcaacttcgg gtgtgtgtga       60

caagggagtg gtgggtgcag tggtggcgga cacagcgatc ccgttttctt ctctctgcac      120


<210>  19
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (67)..(100)
<223>  loxP

<220>
<221>  misc_feature
<222>  (101)..(160)
<223>  Cassette

<400>  19
tgttatttac agatacgtga gtttgggcaa attattgttc tctgtgtccc agctgtaaac       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat atgcatggcc tccgcgccgg      120

gttttggcgc ctcccgcggg cgcccccctc ctcacggcga                            160


<210>  20
<211>  191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Cassette

<220>
<221>  misc_feature
<222>  (61)..(94)
<223>  loxP

<220>
<221>  misc_feature
<222>  (100)..(125)
<223>  I-CeuI

<220>
<221>  misc_feature
<222>  (126)..(131)
<223>  NheI

<220>
<221>  misc_feature
<222>  (132)..(191)
<223>  Mouse Sequence

<400>  20
tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagt aactataacg gtcctaaggt      120

agcgagctag ccgtggacag atacagcaac gtgagctagt tattctgtcc taaagtctca      180

gttggaagat g                                                           191


<210>  21
<211>  9692
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(69)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (70)..(3976)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (3977)..(3982)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (3983)..(4016)
<223>  loxP

<220>
<221>  misc_feature
<222>  (4023)..(5235)
<223>  Human Ubiquitin Promoter

<220>
<221>  misc_feature
<222>  (5236)..(5302)
<223>  EM7 Promoter

<220>
<221>  misc_feature
<222>  (5303)..(6328)
<223>  Hygromycin Resistance Gene

<220>
<221>  misc_feature
<222>  (6329)..(6813)
<223>  PGK polyA

<220>
<221>  misc_feature
<222>  (6825)..(7506)
<223>  Prm Promoter

<220>
<221>  misc_feature
<222>  (7507)..(8646)
<223>  Crei

<220>
<221>  misc_feature
<222>  (8909)..(9119)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (9124)..(9157)
<223>  loxP

<220>
<221>  misc_feature
<222>  (9163)..(9188)
<223>  I-CeuI

<220>
<221>  misc_feature
<222>  (9189)..(9194)
<223>  NheI

<220>
<221>  misc_feature
<222>  (9195)..(9692)
<223>  Mouse Sequence

<400>  21
gtgtgatcac atcccaaagt gggtggccag ggctgggcag agaaaggggg caacttcggg       60

tgtgtgtgac aagggagtgg tgggtgcagt ggtggcggac acagcgatcc cgttttcttc      120

tctctgcacg ctgtcctggc cagactccca gctgcaggag gagctgcggg gcctgagaga      180

gacgttcagc aacttcacag cgagcacgga ggcccaggtc aagggcttga gcacccaggg      240

tgagggcgct ggggcggggc tggggctggg gctggggctg gggggctgtc gggaacgctg      300

agcgagcctc tcccgcagga ggcaatgtgg gaagaaagat gaagtcgcta gagtcccagc      360

tggagaaaca gcagaaggac ctgagtgaag gtcagagagg gagtgtgtgt gtgtgtgtgt      420

gtgtgtgaaa gagagtgaga atgtgtggat gtgtgtgaga aagtgtgagt gtgtgtggat      480

gtgtgtgaga atgagaggga gtgtgtgtgt gtgtgagtct gtgtgtgaga atgaggggga      540

gtgtgttttg ggtgtgtgta tgagagcctt gtgtggatgt gagaatgaga gggagtgtgt      600

atgtctgtga gtgtgagaat gagatggagt gtgtgtgagt ctgtgtgtga gaatgaggtg      660

tgtgtgtgtg agaatgagat ggtgtgtgtg tgggaatgag agggggtgtg tgtctgagtg      720

tgagaatgag atagagtgtg tgtgagacag tctgtgggaa tgagagggag tgtgtgtgag      780

agtgtgagaa tgacggagtg tgtctgtgag tgtgataatg aggtgtgtgt gagtctgagt      840

gtaagaatga gatggggtgt gtgtgtctgt gagtgtgaga gtgtgagaat gaggggtgtt      900

tgtgtctgag tgtgagtctg tgagtgtgag aatgagatgg ggtgtgtgag tgagtgtgag      960

aatgagatgg ggtgtgtgtg tctgtgagtg tgtgtgtgtt tgtgagtgtg agaatgagat     1020

ggggtgtgtg tgagtgtgag aatgagatgg ggtgtgtgtc tgtgtgtgag aatgagatgg     1080

gtgtgtgtgt gacagagtct gagtgtgaga atgagaggga gtgtgtgtga gtgtgagaat     1140

gagaaggagt ggatgggtgt gtgagtctgt gtgaatgagg gagtgggtgt gtgtacgagt     1200

gtgagtctgt gtttatgtgt gagaatgtgt cagtgtatgt gtgtgagaac gtgtgtatgt     1260

gtgttagtgt gtgttgcgtg tgtgggggaa tgagagggat tgtgtctgtg agtgtgagaa     1320

tgagatggag tgtctgtgag actgtgtgtg aggagtggga gtgtgtgtga gaatgagatg     1380

ggtgtgtgtg tctgagtgtg tgtctgtgag aatgagaggg agtgtgtgtg tgtgtgagag     1440

cctgtgtgaa aatgagaagg agtgtggatg ggtgtttgtg agtgggagag tctgtgtgtt     1500

tatgtgtgtg agaatgaggg agtgtgggtg tgtgtgcgaa tgtgagtctg tgtttatgtg     1560

tgtgagaatg tgtcagtgta tgtgagaacg tgtgtgttag tgtgttgcgt gtgtgagaat     1620

gtaagtatat gtgtaagtgc atgtgagtgt gtgtatgtgc gtgttgtgtg aatgtgcatt     1680

gtgtgtgcat gtgtgaaaga gtatatgtgt gttgtgggtg agtgtgtgtg gtgtgtgtag     1740

tgggtgaggg tgtgttgtat gtgtgggtgt gcgttgtgtg aatgtgtgta tgtgggtgag     1800

ggtgtgtgtg cctgtgtgag ggtgtgttgt ggtttttgtg tgtgtttggg tgagggtgtg     1860

ttgtgtgtgt gtgtgggtga aggtgtgttg tgtgtgtcgt gggtgaaggt gtgttgtgtg     1920

tgtagtgact gtagattagg gtgtgttccg tgtgtgtgtg tgagggtgta tgttgtgggt     1980

gttttgtgtg tgagtgggtg tgtaagggtg tgttgtgtgt atgtgggtta aggtgtgtta     2040

tgcgtgaggg tgtattgtgt gtgtgttttg tgtgtgttgt gtgtatgtgg gttagggtgt     2100

gttgtgtgtt tgtgtgtttt gtgtgttgtc tgtgtatgtg ggttacggtg tgttgtgcgt     2160

gtgagggtgt gttgtgtatg gtgtgttgtg tgtgttgtgt gagtgtgtat gtgagttagg     2220

gtgtgttgtg tctatgtatg tgtgtgtaag ggtgtgttgt gtgtctgtgg gtgtgttttg     2280

tgtatgtggg ttagggtgtg ttgtgtgttc tgtattgtgt gttttatgtg ttgtctgtat     2340

gtgggttatg tgtgttgtgt gtgttgtgga tgtatgtggg ttagggtgtg ttgtgtgtct     2400

ctgtgtgttg tctgcgtttg tgtctgtggg ttagggtgtg ttgtatgtgt tgtgttttgt     2460

gtgttgtccg tgtgtgtgta tgtgggttag gttgtgtgtg tgtgtgttgt atattgtctg     2520

tgtgtgtgtg ttaggatgtg ttgtgtgtct gtgtgagtgt gtgtgtaagg gtgtgttgtg     2580

tgtgtaggag tgtgtgtgtg tgtgtgtatg ggggtctctc aggccaactc cgctgctgtt     2640

tgtggcaatg cgacgggtgt tcgggtccca gcaggaggat gtagggctga cctcgtttcc     2700

cgtttccctc cccgtggttt ccgcatctcc tcccgctccc ctccgcccgg tctccccaga     2760

tcactccagc ctgctgctcc acgtgaagca gttcgtgtct gacctgcgga gcctgagctg     2820

tcagatggcg gcgctccagg gcaatggtaa ggaggccagc ccggcccgct ctctgcctcc     2880

ccccttctct gggcagcgct tagcccctgc gccccgtttc tcccgctcag gctcagaaag     2940

gacctgctgc ccggtcaact gggtggagca cgagcgcagc tgctactggt tctctcgctc     3000

cgggaaggcc tgggctgacg ccgacaacta ctgccggctg gaggacgcgc acctggtggt     3060

ggtcacgtcc tgggaggagc aggtgaggac ccggagggtc tgggaggctg gctggcctcg     3120

gagagatcac cacccgcctt ctctctcctc agaaatttgt ccagcaccac ataggccctg     3180

tgaacacctg gatgggcctc cacgaccaaa acgggccctg gaagtgggtg gacgggacgg     3240

actacgagac gggcttcaag tgagtgcgcg ccctccctcg gcctgggtcc ggccgccttc     3300

gcgccctggg gccctgggct gaggagtctg gagcgacccg cctgcggatc cgacctcctg     3360

gggcccacag ctggctctgt ccccaggaac tggaggccgg agcagccgga cgactggtac     3420

ggccacgggc tcggaggagg cgaggactgt gcccacttca ccgacgacgg ccgctggaac     3480

gacgacgtct gccagaggcc ctaccgctgg gtctgcgaga cagagctgga caaggccagc     3540

caggagccac ctctccttta atttatttct tcaatgcctc gacctgccgc aggggtccgg     3600

gattgggaat ccgcccatct gggggcctct tctgctttct cgggaatttt catctaggat     3660

tttaagggaa ggggaaggat agggtgatgt tccgaaggtg aggagcttga aacccgtggc     3720

gctttctgca gtttgcaggt tatcattgtg aacttttttt ttttaagagt aaaaagaaat     3780

atacctaaac cttctgttag ttgtctggtt attggggatt cggaagcagg agtgggctgg     3840

ttggcattac gaagccttag cgggtgctgt ggcatcatga gaactgtgtg ggctttgggc     3900

cagaatggcc agactttgtt atttacagat acgtgagttt gggcaaatta ttgttctctg     3960

tgtcccagct gtaaacctcg agataacttc gtataatgta tgctatacga agttatatgc     4020

atggcctccg cgccgggttt tggcgcctcc cgcgggcgcc cccctcctca cggcgagcgc     4080

tgccacgtca gacgaagggc gcagcgagcg tcctgatcct tccgcccgga cgctcaggac     4140

agcggcccgc tgctcataag actcggcctt agaaccccag tatcagcaga aggacatttt     4200

aggacgggac ttgggtgact ctagggcact ggttttcttt ccagagagcg gaacaggcga     4260

ggaaaagtag tcccttctcg gcgattctgc ggagggatct ccgtggggcg gtgaacgccg     4320

atgattatat aaggacgcgc cgggtgtggc acagctagtt ccgtcgcagc cgggatttgg     4380

gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg gtgagtagcg ggctgctggg     4440

ctggccgggg ctttcgtggc cgccgggccg ctcggtggga cggaagcgtg tggagagacc     4500

gccaagggct gtagtctggg tccgcgagca aggttgccct gaactggggg ttggggggag     4560

cgcagcaaaa tggcggctgt tcccgagtct tgaatggaag acgcttgtga ggcgggctgt     4620

gaggtcgttg aaacaaggtg gggggcatgg tgggcggcaa gaacccaagg tcttgaggcc     4680

ttcgctaatg cgggaaagct cttattcggg tgagatgggc tggggcacca tctggggacc     4740

ctgacgtgaa gtttgtcact gactggagaa ctcggtttgt cgtctgttgc gggggcggca     4800

gttatggcgg tgccgttggg cagtgcaccc gtacctttgg gagcgcgcgc cctcgtcgtg     4860

tcgtgacgtc acccgttctg ttggcttata atgcagggtg gggccacctg ccggtaggtg     4920

tgcggtaggc ttttctccgt cgcaggacgc agggttcggg cctagggtag gctctcctga     4980

atcgacaggc gccggacctc tggtgagggg agggataagt gaggcgtcag tttctttggt     5040

cggttttatg tacctatctt cttaagtagc tgaagctccg gttttgaact atgcgctcgg     5100

ggttggcgag tgtgttttgt gaagtttttt aggcaccttt tgaaatgtaa tcatttgggt     5160

caatatgtaa ttttcagtgt tagactagta aattgtccgc taaattctgg ccgtttttgg     5220

cttttttgtt agacgtgttg acaattaatc atcggcatag tatatcggca tagtataata     5280

cgacaaggtg aggaactaaa ccatgaaaaa gcctgaactc accgcgacgt ctgtcgagaa     5340

gtttctgatc gaaaagttcg acagcgtgtc cgacctgatg cagctctcgg agggcgaaga     5400

atctcgtgct ttcagcttcg atgtaggagg gcgtggatat gtcctgcggg taaatagctg     5460

cgccgatggt ttctacaaag atcgttatgt ttatcggcac tttgcatcgg ccgcgctccc     5520

gattccggaa gtgcttgaca ttggggaatt cagcgagagc ctgacctatt gcatctcccg     5580

ccgtgcacag ggtgtcacgt tgcaagacct gcctgaaacc gaactgcccg ctgttctgca     5640

gccggtcgcg gaggccatgg atgcgattgc tgcggccgat cttagccaga cgagcgggtt     5700

cggcccattc ggaccgcaag gaatcggtca atacactaca tggcgtgatt tcatatgcgc     5760

gattgctgat ccccatgtgt atcactggca aactgtgatg gacgacaccg tcagtgcgtc     5820

cgtcgcgcag gctctcgatg agctgatgct ttgggccgag gactgccccg aagtccggca     5880

cctcgtgcac gcggatttcg gctccaacaa tgtcctgacg gacaatggcc gcataacagc     5940

ggtcattgac tggagcgagg cgatgttcgg ggattcccaa tacgaggtcg ccaacatctt     6000

cttctggagg ccgtggttgg cttgtatgga gcagcagacg cgctacttcg agcggaggca     6060

tccggagctt gcaggatcgc cgcggctccg ggcgtatatg ctccgcattg gtcttgacca     6120

actctatcag agcttggttg acggcaattt cgatgatgca gcttgggcgc agggtcgatg     6180

cgacgcaatc gtccgatccg gagccgggac tgtcgggcgt acacaaatcg cccgcagaag     6240

cgcggccgtc tggaccgatg gctgtgtaga agtactcgcc gatagtggaa accgacgccc     6300

cagcactcgt ccgagggcaa aggaataggg ggatccgctg taagtctgca gaaattgatg     6360

atctattaaa caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa     6420

gaagggtgag aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg     6480

gtggggtggg attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg     6540

ataatgtttc atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct     6600

cattcctccc actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc     6660

ttgattccca ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct     6720

gaagaacgag atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca     6780

agttctaatt ccatcagacc tcgacctgca gcccctagcc cgggcgccag tagcagcacc     6840

cacgtccacc ttctgtctag taatgtccaa cacctccctc agtccaaaca ctgctctgca     6900

tccatgtggc tcccatttat acctgaagca cttgatgggg cctcaatgtt ttactagagc     6960

ccacccccct gcaactctga gaccctctgg atttgtctgt cagtgcctca ctggggcgtt     7020

ggataatttc ttaaaaggtc aagttccctc agcagcattc tctgagcagt ctgaagatgt     7080

gtgcttttca cagttcaaat ccatgtggct gtttcaccca cctgcctggc cttgggttat     7140

ctatcaggac ctagcctaga agcaggtgtg tggcacttaa cacctaagct gagtgactaa     7200

ctgaacactc aagtggatgc catctttgtc acttcttgac tgtgacacaa gcaactcctg     7260

atgccaaagc cctgcccacc cctctcatgc ccatatttgg acatggtaca ggtcctcact     7320

ggccatggtc tgtgaggtcc tggtcctctt tgacttcata attcctaggg gccactagta     7380

tctataagag gaagagggtg ctggctccca ggccacagcc cacaaaattc cacctgctca     7440

caggttggct ggctcgaccc aggtggtgtc ccctgctctg agccagctcc cggccaagcc     7500

agcaccatgg gtacccccaa gaagaagagg aaggtgcgta ccgatttaaa ttccaattta     7560

ctgaccgtac accaaaattt gcctgcatta ccggtcgatg caacgagtga tgaggttcgc     7620

aagaacctga tggacatgtt cagggatcgc caggcgtttt ctgagcatac ctggaaaatg     7680

cttctgtccg tttgccggtc gtgggcggca tggtgcaagt tgaataaccg gaaatggttt     7740

cccgcagaac ctgaagatgt tcgcgattat cttctatatc ttcaggcgcg cggtctggca     7800

gtaaaaacta tccagcaaca tttgggccag ctaaacatgc ttcatcgtcg gtccgggctg     7860

ccacgaccaa gtgacagcaa tgctgtttca ctggttatgc ggcggatccg aaaagaaaac     7920

gttgatgccg gtgaacgtgc aaaacaggct ctagcgttcg aacgcactga tttcgaccag     7980

gttcgttcac tcatggaaaa tagtgatcgc tgccaggata tacgtaatct ggcatttctg     8040

gggattgctt ataacaccct gttacgtata gccgaaattg ccaggatcag ggttaaagat     8100

atctcacgta ctgacggtgg gagaatgtta atccatattg gcagaacgaa aacgctggtt     8160

agcaccgcag gtgtagagaa ggcacttagc ctgggggtaa ctaaactggt cgagcgatgg     8220

atttccgtct ctggtgtagc tgatgatccg aataactacc tgttttgccg ggtcagaaaa     8280

aatggtgttg ccgcgccatc tgccaccagc cagctatcaa ctcgcgccct ggaagggatt     8340

tttgaagcaa ctcatcgatt gatttacggc gctaaggtaa atataaaatt tttaagtgta     8400

taatgtgtta aactactgat tctaattgtt tgtgtatttt aggatgactc tggtcagaga     8460

tacctggcct ggtctggaca cagtgcccgt gtcggagccg cgcgagatat ggcccgcgct     8520

ggagtttcaa taccggagat catgcaagct ggtggctgga ccaatgtaaa tattgtcatg     8580

aactatatcc gtaacctgga tagtgaaaca ggggcaatgg tgcgcctgct ggaagatggc     8640

gattgatcta gataagtaat gatcataatc agccatatca catctgtaga ggttttactt     8700

gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt     8760

gttgttaaac ctgccctagt tgcggccaat tccagctgag cgtgcctccg caccattacc     8820

agttggtctg gtgtcaaaaa taataataac cgggcagggg ggatctaagc tctagataag     8880

taatgatcat aatcagccat atcacatctg tagaggtttt acttgcttta aaaaacctcc     8940

cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta     9000

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat     9060

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     9120

ggaataactt cgtataatgt atgctatacg aagttatgct agtaactata acggtcctaa     9180

ggtagcgagc tagccgtgga cagatacagc aacgtgagct agttattctg tcctaaagtc     9240

tcagttggaa gatgggagga tttttgacct ctgtctgctg ggggcaggac caaccaccag     9300

ggaactgcag cccccctgtg ctgagtgcat cagagacttg gaatggaaca cactggcctg     9360

cgacactcat cacaacgaac agaaactgct ttgtacactg aataaacgca gtgaataccc     9420

agctcaggat cacagacaca tgaatgcaaa gttatattag tataaccaag ggtgggaatg     9480

agggcaatta cagataactt atagacatga attactaaca aaacagggca aaatgtttgc     9540

tcataaataa catgaaaata caatatatag tcatatgtat atatacatgt atatatataa     9600

atgacataat atgtatatat ttttacaaat acactgcagg aaaataatat ttttcctcta     9660

cagaagagat tggcaaatct gacatctaaa at                                   9692


<210>  22
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(90)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (91)..(160)
<223>  Human Sequence

<400>  22
catgatgttt ctttcttagg aaagccaggg catttctcta ttctccaatc tcttggctca       60

atgcccttgg cctctctttt gttccactag tgaagcctct ccagccaggg gctgaggtcc      120

cggtggtgtg ggcccaggag ggggctcctg cccagctccc                            160


<210>  23
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (67)..(100)
<223>  loxP

<220>
<221>  misc_feature
<222>  (106)..(131)
<223>  I-CeuI

<220>
<221>  misc_feature
<222>  (132)..(137)
<223>  NheI

<220>
<221>  misc_feature
<222>  (138)..(197)
<223>  Mouse Sequence

<400>  23
tgttatttac agatacgtga gtttgggcaa attattgttc tctgtgtccc agctgtaaac       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc      120

taaggtagcg agctagccgt ggacagatac agcaacgtga gctagttatt ctgtcctaaa      180

gtctcagttg gaagatg                                                     197


<210>  24
<211>  4551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(69)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (70)..(3976)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (3977)..(3982)
<223>  XhoI

<220>
<221>  misc_feature
<222>  (3983)..(4016)
<223>  LoxP

<220>
<221>  misc_feature
<222>  (4022)..(4047)
<223>  I-CeuI

<220>
<221>  misc_feature
<222>  (4048)..(4053)
<223>  NheI

<220>
<221>  misc_feature
<222>  (4054)..(4551)
<223>  Mouse Sequence

<400>  24
gtgtgatcac atcccaaagt gggtggccag ggctgggcag agaaaggggg caacttcggg       60

tgtgtgtgac aagggagtgg tgggtgcagt ggtggcggac acagcgatcc cgttttcttc      120

tctctgcacg ctgtcctggc cagactccca gctgcaggag gagctgcggg gcctgagaga      180

gacgttcagc aacttcacag cgagcacgga ggcccaggtc aagggcttga gcacccaggg      240

tgagggcgct ggggcggggc tggggctggg gctggggctg gggggctgtc gggaacgctg      300

agcgagcctc tcccgcagga ggcaatgtgg gaagaaagat gaagtcgcta gagtcccagc      360

tggagaaaca gcagaaggac ctgagtgaag gtcagagagg gagtgtgtgt gtgtgtgtgt      420

gtgtgtgaaa gagagtgaga atgtgtggat gtgtgtgaga aagtgtgagt gtgtgtggat      480

gtgtgtgaga atgagaggga gtgtgtgtgt gtgtgagtct gtgtgtgaga atgaggggga      540

gtgtgttttg ggtgtgtgta tgagagcctt gtgtggatgt gagaatgaga gggagtgtgt      600

atgtctgtga gtgtgagaat gagatggagt gtgtgtgagt ctgtgtgtga gaatgaggtg      660

tgtgtgtgtg agaatgagat ggtgtgtgtg tgggaatgag agggggtgtg tgtctgagtg      720

tgagaatgag atagagtgtg tgtgagacag tctgtgggaa tgagagggag tgtgtgtgag      780

agtgtgagaa tgacggagtg tgtctgtgag tgtgataatg aggtgtgtgt gagtctgagt      840

gtaagaatga gatggggtgt gtgtgtctgt gagtgtgaga gtgtgagaat gaggggtgtt      900

tgtgtctgag tgtgagtctg tgagtgtgag aatgagatgg ggtgtgtgag tgagtgtgag      960

aatgagatgg ggtgtgtgtg tctgtgagtg tgtgtgtgtt tgtgagtgtg agaatgagat     1020

ggggtgtgtg tgagtgtgag aatgagatgg ggtgtgtgtc tgtgtgtgag aatgagatgg     1080

gtgtgtgtgt gacagagtct gagtgtgaga atgagaggga gtgtgtgtga gtgtgagaat     1140

gagaaggagt ggatgggtgt gtgagtctgt gtgaatgagg gagtgggtgt gtgtacgagt     1200

gtgagtctgt gtttatgtgt gagaatgtgt cagtgtatgt gtgtgagaac gtgtgtatgt     1260

gtgttagtgt gtgttgcgtg tgtgggggaa tgagagggat tgtgtctgtg agtgtgagaa     1320

tgagatggag tgtctgtgag actgtgtgtg aggagtggga gtgtgtgtga gaatgagatg     1380

ggtgtgtgtg tctgagtgtg tgtctgtgag aatgagaggg agtgtgtgtg tgtgtgagag     1440

cctgtgtgaa aatgagaagg agtgtggatg ggtgtttgtg agtgggagag tctgtgtgtt     1500

tatgtgtgtg agaatgaggg agtgtgggtg tgtgtgcgaa tgtgagtctg tgtttatgtg     1560

tgtgagaatg tgtcagtgta tgtgagaacg tgtgtgttag tgtgttgcgt gtgtgagaat     1620

gtaagtatat gtgtaagtgc atgtgagtgt gtgtatgtgc gtgttgtgtg aatgtgcatt     1680

gtgtgtgcat gtgtgaaaga gtatatgtgt gttgtgggtg agtgtgtgtg gtgtgtgtag     1740

tgggtgaggg tgtgttgtat gtgtgggtgt gcgttgtgtg aatgtgtgta tgtgggtgag     1800

ggtgtgtgtg cctgtgtgag ggtgtgttgt ggtttttgtg tgtgtttggg tgagggtgtg     1860

ttgtgtgtgt gtgtgggtga aggtgtgttg tgtgtgtcgt gggtgaaggt gtgttgtgtg     1920

tgtagtgact gtagattagg gtgtgttccg tgtgtgtgtg tgagggtgta tgttgtgggt     1980

gttttgtgtg tgagtgggtg tgtaagggtg tgttgtgtgt atgtgggtta aggtgtgtta     2040

tgcgtgaggg tgtattgtgt gtgtgttttg tgtgtgttgt gtgtatgtgg gttagggtgt     2100

gttgtgtgtt tgtgtgtttt gtgtgttgtc tgtgtatgtg ggttacggtg tgttgtgcgt     2160

gtgagggtgt gttgtgtatg gtgtgttgtg tgtgttgtgt gagtgtgtat gtgagttagg     2220

gtgtgttgtg tctatgtatg tgtgtgtaag ggtgtgttgt gtgtctgtgg gtgtgttttg     2280

tgtatgtggg ttagggtgtg ttgtgtgttc tgtattgtgt gttttatgtg ttgtctgtat     2340

gtgggttatg tgtgttgtgt gtgttgtgga tgtatgtggg ttagggtgtg ttgtgtgtct     2400

ctgtgtgttg tctgcgtttg tgtctgtggg ttagggtgtg ttgtatgtgt tgtgttttgt     2460

gtgttgtccg tgtgtgtgta tgtgggttag gttgtgtgtg tgtgtgttgt atattgtctg     2520

tgtgtgtgtg ttaggatgtg ttgtgtgtct gtgtgagtgt gtgtgtaagg gtgtgttgtg     2580

tgtgtaggag tgtgtgtgtg tgtgtgtatg ggggtctctc aggccaactc cgctgctgtt     2640

tgtggcaatg cgacgggtgt tcgggtccca gcaggaggat gtagggctga cctcgtttcc     2700

cgtttccctc cccgtggttt ccgcatctcc tcccgctccc ctccgcccgg tctccccaga     2760

tcactccagc ctgctgctcc acgtgaagca gttcgtgtct gacctgcgga gcctgagctg     2820

tcagatggcg gcgctccagg gcaatggtaa ggaggccagc ccggcccgct ctctgcctcc     2880

ccccttctct gggcagcgct tagcccctgc gccccgtttc tcccgctcag gctcagaaag     2940

gacctgctgc ccggtcaact gggtggagca cgagcgcagc tgctactggt tctctcgctc     3000

cgggaaggcc tgggctgacg ccgacaacta ctgccggctg gaggacgcgc acctggtggt     3060

ggtcacgtcc tgggaggagc aggtgaggac ccggagggtc tgggaggctg gctggcctcg     3120

gagagatcac cacccgcctt ctctctcctc agaaatttgt ccagcaccac ataggccctg     3180

tgaacacctg gatgggcctc cacgaccaaa acgggccctg gaagtgggtg gacgggacgg     3240

actacgagac gggcttcaag tgagtgcgcg ccctccctcg gcctgggtcc ggccgccttc     3300

gcgccctggg gccctgggct gaggagtctg gagcgacccg cctgcggatc cgacctcctg     3360

gggcccacag ctggctctgt ccccaggaac tggaggccgg agcagccgga cgactggtac     3420

ggccacgggc tcggaggagg cgaggactgt gcccacttca ccgacgacgg ccgctggaac     3480

gacgacgtct gccagaggcc ctaccgctgg gtctgcgaga cagagctgga caaggccagc     3540

caggagccac ctctccttta atttatttct tcaatgcctc gacctgccgc aggggtccgg     3600

gattgggaat ccgcccatct gggggcctct tctgctttct cgggaatttt catctaggat     3660

tttaagggaa ggggaaggat agggtgatgt tccgaaggtg aggagcttga aacccgtggc     3720

gctttctgca gtttgcaggt tatcattgtg aacttttttt ttttaagagt aaaaagaaat     3780

atacctaaac cttctgttag ttgtctggtt attggggatt cggaagcagg agtgggctgg     3840

ttggcattac gaagccttag cgggtgctgt ggcatcatga gaactgtgtg ggctttgggc     3900

cagaatggcc agactttgtt atttacagat acgtgagttt gggcaaatta ttgttctctg     3960

tgtcccagct gtaaacctcg agataacttc gtataatgta tgctatacga agttatgcta     4020

gtaactataa cggtcctaag gtagcgagct agccgtggac agatacagca acgtgagcta     4080

gttattctgt cctaaagtct cagttggaag atgggaggat ttttgacctc tgtctgctgg     4140

gggcaggacc aaccaccagg gaactgcagc ccccctgtgc tgagtgcatc agagacttgg     4200

aatggaacac actggcctgc gacactcatc acaacgaaca gaaactgctt tgtacactga     4260

ataaacgcag tgaataccca gctcaggatc acagacacat gaatgcaaag ttatattagt     4320

ataaccaagg gtgggaatga gggcaattac agataactta tagacatgaa ttactaacaa     4380

aacagggcaa aatgtttgct cataaataac atgaaaatac aatatatagt catatgtata     4440

tatacatgta tatatataaa tgacataata tgtatatatt tttacaaata cactgcagga     4500

aaataatatt tttcctctac agaagagatt ggcaaatctg acatctaaaa t              4551


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gaacaaaaac tcatctcaga agaggatctg                                        30


<210>  27
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Gln Asn Ser Gln Leu Gln Glu Glu Leu Arg Gly Leu Arg Glu Thr 
1               5                   10                  15      


Phe Ser Asn Phe Thr Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser 
            20                  25                  30          


Thr Gln Gly Gly Asn Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln 
        35                  40                  45              


Leu Glu Lys Gln Gln Lys Asp Leu Ser Glu Asp His Ser Ser Leu 
    50                  55                  60              


<210>  28
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  28

His Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala Trp Ala 
1               5                   10                  15      


Asp Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val Val Val 
            20                  25                  30          


Thr Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly Pro Val 
        35                  40                  45              


Asn Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys Trp Val 
    50                  55                  60                  


Asp Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Glu Gln 
65                  70                  75                  80  


Pro Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala 
                85                  90                  95      


His Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro 
            100                 105                 110         


Tyr Arg Trp Val Cys Glu 
        115             


<210>  29
<211>  39
<212>  PRT
<213>  Mus musculus

<400>  29

Met Thr Lys Asp Tyr Gln Asp Phe Gln His Leu Asp Asn Asp Asn Asp 
1               5                   10                  15      


His His Gln Leu Arg Arg Gly Pro Pro Pro Thr Pro Arg Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Ser Arg 
        35                  


<210>  30
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  30

Leu Leu Leu Leu Ser Ser Ser Leu Ser Ile Leu Leu Leu Val Val Val 
1               5                   10                  15      


Cys Val Ile Thr Ser 
            20      


<210>  31
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  31

Asn Ser Gln Leu Gln Glu Glu Leu Arg Gly Leu Arg Glu Thr Phe Ser 
1               5                   10                  15      


Asn Phe Thr Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser Thr Gln 
            20                  25                  30          


Gly Gly Asn Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln Leu Glu 
        35                  40                  45              


Lys Gln Gln Lys Asp Leu Ser Glu Asp His Ser Ser Leu Leu Leu His 
    50                  55                  60                  


Val Lys Gln Phe Val Ser Asp Leu Arg Ser Leu Ser Cys Gln Met Ala 
65                  70                  75                  80  


Ala Leu Gln Gly Asn Gly Ser Glu Arg Thr Cys Cys Pro Val Asn Trp 
                85                  90                  95      


Val Glu His Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala 
            100                 105                 110         


Trp Ala Asp Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val 
        115                 120                 125             


Val Val Thr Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly 
    130                 135                 140                 


Pro Val Asn Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys 
145                 150                 155                 160 


Trp Val Asp Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro 
                165                 170                 175     


Glu Gln Pro Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp 
            180                 185                 190         


Cys Ala His Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln 
        195                 200                 205             


Arg Pro Tyr Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala Ser Gln 
    210                 215                 220                 


Glu Pro Pro Leu Leu 
225                 


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
ggagtaccag ctcccgtacg                                                   20


<210>  33
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ctcttctgag atgagttttt gttcgttgcc tctctggagg ttg                         43


<210>  34
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
aaactcatct cagaagagga tctgagacaa gcagctaccg cag                         43


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
tccgcccgct gtttaaac                                                     18


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ggaaccccta gtgatggagt t                                                 21


<210>  37
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cggcctcagt gagcga                                                       16


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
cactccctct ctgcgcgctc g                                                 21


<210>  39
<211>  291
<212>  PRT
<213>  Macaca fascicularis

<400>  39

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu Asp Asn Glu Glu Ser 
1               5                   10                  15      


Asp His His Gln Leu Gly Lys Gly Pro Pro Pro Pro Gln Ser Leu Leu 
            20                  25                  30          


Arg Arg Leu Cys Ser Gly Pro Arg Leu Leu Leu Leu Ser Leu Gly Leu 
        35                  40                  45              


Ser Leu Leu Leu Leu Val Val Val Cys Val Ile Gly Ser Gln Asn Ala 
    50                  55                  60                  


Gln Leu Gln Arg Glu Leu Arg Gly Leu Arg Glu Thr Leu Ser Asn Phe 
65                  70                  75                  80  


Thr Ala Ser Thr Glu Ala Gln Val Lys Gly Leu Ser Thr Gln Gly Gly 
                85                  90                  95      


Asn Val Gly Arg Lys Met Lys Ser Leu Glu Ser Gln Leu Glu Lys Gln 
            100                 105                 110         


Gln Lys Asp Leu Ser Glu Asp His Ser Ser Leu Leu Leu His Val Lys 
        115                 120                 125             


Gln Phe Val Ser Asp Leu Arg Ser Leu Ser Cys Gln Met Ala Ala Leu 
    130                 135                 140                 


Gln Gly Asn Gly Ser Glu Arg Ala Cys Cys Pro Val Asn Trp Val Glu 
145                 150                 155                 160 


His Glu Arg Ser Cys Tyr Trp Phe Ser Arg Ser Gly Lys Ala Trp Ala 
                165                 170                 175     


Asp Ala Asp Asn Tyr Cys Arg Leu Glu Asp Ala His Leu Val Val Val 
            180                 185                 190         


Thr Ser Trp Glu Glu Gln Lys Phe Val Gln His His Ile Gly Pro Val 
        195                 200                 205             


Asn Thr Trp Met Gly Leu His Asp Gln Asn Gly Pro Trp Lys Trp Val 
    210                 215                 220                 


Asp Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Glu Gln 
225                 230                 235                 240 


Pro Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala 
                245                 250                 255     


His Phe Thr Asp Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro 
            260                 265                 270         


Tyr Arg Trp Val Cys Glu Thr Glu Leu Asp Lys Ala Ser Gln Glu Pro 
        275                 280                 285             


Pro Leu Leu 
    290     


<210>  40
<211>  876
<212>  DNA
<213>  Macaca fascicularis

<400>  40
atgaccaagg agtatcagga cctgcagcat ctggacaatg aggagagtga ccaccatcag       60

ctcggaaaag ggccacctcc tccgcagtcc ctcctgcggc gtctctgctc cggccctcgc      120

ctcctcctgc tctccctggg cctcagcctc ctgctgctgg tggttgtctg tgtgatcgga      180

tcccaaaacg cccagctgca gcgggagctg cggggcctga gagagacgct cagcaacttc      240

acagcgagca ccgaggccca ggtcaagggc ttgagcaccc agggaggcaa tgtgggaaga      300

aagatgaagt cgctggagtc ccagctggag aaacagcaga aggacttgag tgaagatcac      360

tccagcctgc tgctccacgt gaagcagttc gtgtctgacc tgcggagcct gagctgtcag      420

atggcggcgc tccagggcaa tggctcggaa agggcctgct gcccagtcaa ctgggtggag      480

cacgagcgca gctgctactg gttctctcgc tccgggaagg cctgggccga cgccgacaac      540

tactgccggc tggaggacgc gcacctggtg gtggtcacgt cctgggagga gcagaaattt      600

gtccagcacc acataggtcc tgtgaacacc tggatgggcc tccacgacca aaacgggccc      660

tggaagtggg tggacgggac ggactacgag acgggcttca agaactggag accggagcag      720

ccggacgact ggtacggcca cgggctcggg ggaggggagg actgtgccca cttcaccgac      780

gacggccgct ggaacgacga cgtctgccag aggccctacc gctgggtctg cgagacagag      840

ctggacaagg ccagtcagga gccacctctc ctttaa                                876


<210>  41
<211>  284
<212>  PRT
<213>  Rattus norvegicus

<400>  41

Met Thr Lys Asp Tyr Gln Asp Phe Gln His Leu Asp Asn Glu Asn Asp 
1               5                   10                  15      


His His Gln Leu Gln Arg Gly Pro Pro Pro Ala Pro Arg Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Phe Arg Leu Phe Leu Leu Ser Leu Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Leu Val Val Val Cys Val Ile Thr Ser Gln Asn Ser Gln 
    50                  55                  60                  


Leu Arg Glu Asp Leu Arg Val Leu Arg Gln Asn Phe Ser Asn Phe Thr 
65                  70                  75                  80  


Val Ser Thr Glu Asp Gln Val Lys Ala Leu Thr Thr Gln Gly Glu Arg 
                85                  90                  95      


Val Gly Arg Lys Met Lys Leu Val Glu Ser Gln Leu Glu Lys His Gln 
            100                 105                 110         


Glu Asp Leu Arg Glu Asp His Ser Arg Leu Leu Leu His Val Lys Gln 
        115                 120                 125             


Leu Val Ser Asp Val Arg Ser Leu Ser Cys Gln Met Ala Ala Leu Arg 
    130                 135                 140                 


Gly Asn Gly Ser Glu Arg Ile Cys Cys Pro Ile Asn Trp Val Glu Tyr 
145                 150                 155                 160 


Glu Gly Ser Cys Tyr Trp Phe Ser Ser Ser Val Lys Pro Trp Thr Glu 
                165                 170                 175     


Ala Asp Lys Tyr Cys Gln Leu Glu Asn Ala His Leu Val Val Val Thr 
            180                 185                 190         


Ser Trp Glu Glu Gln Arg Phe Val Gln Gln His Met Gly Pro Leu Asn 
        195                 200                 205             


Thr Trp Ile Gly Leu Thr Asp Gln Asn Gly Pro Trp Lys Trp Val Asp 
    210                 215                 220                 


Gly Thr Asp Tyr Glu Thr Gly Phe Lys Asn Trp Arg Pro Gly Gln Pro 
225                 230                 235                 240 


Asp Asp Trp Tyr Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His 
                245                 250                 255     


Phe Thr Thr Asp Gly His Trp Asn Asp Asp Val Cys Arg Arg Pro Tyr 
            260                 265                 270         


Arg Trp Val Cys Glu Thr Glu Leu Gly Lys Ala Asn 
        275                 280                 


<210>  42
<211>  855
<212>  DNA
<213>  Rattus norvegicus

<400>  42
atgacaaagg attatcaaga tttccagcac ttggacaatg agaacgacca ccatcaactc       60

cagagagggc cacctcccgc tccaaggctc ttgcagcgac tctgctctgg attccgtctc      120

ttcctgcttt ccctgggcct cagcatcctg ctgctggtgg ttgtctgtgt gatcacatcc      180

caaaattccc aactccggga agatctgcgg gttctaaggc agaatttcag caactttacc      240

gtgagcactg aggaccaggt caaggccctg accacccagg gagagagagt gggaagaaag      300

atgaagttag tcgagtcaca gctggaaaaa catcaggagg atctgaggga agaccactct      360

agattgctac tgcatgtaaa gcagttagtg tctgacgtgc gaagcttgag ctgccagatg      420

gccgcacttc ggggcaatgg ctctgaaagg atctgctgcc ccatcaactg ggtggagtat      480

gaaggcagct gctactggtt ctccagctct gtgaagcctt ggacggaagc tgacaagtac      540

tgccagctgg agaacgccca cctggtggtg gtgacttcct gggaggagca gagattcgtc      600

cagcaacaca tgggcccctt aaatacttgg attggcctaa ctgaccagaa cggaccctgg      660

aaatgggtgg atgggacaga ctatgagaca ggcttcaaga actggagacc agggcagcca      720

gatgactggt acggacatgg gcttggaggg ggtgaagact gtgcccactt caccaccgat      780

ggccactgga atgatgacgt ctgcaggagg ccctaccgct gggtctgtga gacagagttg      840

ggcaaggcca attag                                                       855


