                         SEQUENCE LISTING

<110>  Massachusetts Eye and Ear Infirmary
 
<120>  AAV-CRISPR/Cas9 Genome Editing of VEGFR2 for Treating Ocular 
       Diseases

<130>  00633-0232WO1

<150>  US 62/525,545
<151>  2017-06-27

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mK22 target sequence

<400>  1
gtcccggtac gagcacttgt                                                   20


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  control sgRNA sequence

<400>  2
tgcgaatacg cccacgcgat ggg                                               23


<210>  3
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer forward

<400>  3
cgtctagagt agaacgagct ggtgcacgtg gc                                     32


<210>  4
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer reverse

<400>  4
ggaccggtcc aagggctgcc tggagggag                                         29


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  top oligo

<400>  5
accgtcccgg tacgagcact tgt                                               23


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequencing primer

<400>  6
ggactatcat atgcttaccg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer forward

<400>  7
gctcctgtcg ggtcccaagg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse

<400>  8
acctggactg gctttggccc                                                   20


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  off target sequence

<400>  9
ctcacggttg gagcacttgt agg                                               23


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer P25F

<400>  10
agcttcattc agtgtctctg gg                                                22


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer P25R

<400>  11
gggtatttgt aaggtgctgt tga                                               23


<210>  12
<211>  47337
<212>  DNA
<213>  Homo sapiens

<400>  12
actgagtccc gggaccccgg gagagcggtc aatgtgtggt cgctgcgttt cctctgcctg       60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta      120

ccggcacccg cagacgcccc tgcagccgcg gtcggcgccc gggctcccta gccctgtgcg      180

ctcaactgtc ctgcgctgcg gggtgccgcg agttccacct ccgcgcctcc ttctctagac      240

aggcgctggg agaaagaacc ggctcccgag ttctgggcat ttcgcccggc tcgaggtgca      300

ggatgcagag caaggtgctg ctggccgtcg ccctgtggct ctgcgtggag acccgggccg      360

cctctgtggg taaggagccc actctggagg aggaaggcag acaggtcggg tgagggcgga      420

gaggacctga aagccagatc taactcggaa tcgtagagct ggagagttgg acaggacttg      480

acattttgcg atctttcatt taccagtggg gaaactgagg ctcagagact ggcccaagat      540

tacccagcga gtctgtggtc gcctgtgctc tagcccagtt ccttttctag gactctggtt      600

tgcgacaggg acctcggctg gagcatgtcc tgagatgccg acacaccctc aggctcttgg      660

gaggctgggg tgggaaggcg cctggggttg gcaggcagga ggtgcctccg caggcgagaa      720

caggcggtga aaagttgtct ggctgcgcgc aacatcctag tccgggcccg gggaagaaaa      780

ccttgccgga atctcaggcc gggtctcccg gatcggacgg tacactcggt tctgcctctt      840

tgcgggaccc ggcccgttgt tgtcttcatg ctcgaacaca cttgcacacc actgtgtgaa      900

gtggggtctg gagcggagag aaactttttt tccttccttg gtgcaggacg ccgctctcct      960

tgcagagcga agaagggggg gaatagggac ttgtcctggg ggctttgaca gcttccccaa     1020

gggtctccaa gtaacagcca actgtcctgc gtaaagcatt gcacatcttt caaagcgctg     1080

tggtccttgg tgtaagcgca tagtcagaag ttcaagctcc gaaaaccttt cctgtgggcc     1140

ttggtaccta gctttagtgc cattccttcc tctccctgcc gcctaaaatt tccgtctcct     1200

tcaattagga acacacacgt tcttcatgca atagctgtct gtcttttctt cctcactttc     1260

ctttctctct caacccctta gataatattt ctttcctgca gccagtttgc tgatatccag     1320

atttccaccc tttgcagggt gagaaagggg aaagggtcag agaaagaaaa aaaaaaagtc     1380

gaataattca gggaaaaaaa tttcttactc cctaagacaa gaatcacatg tcttagaaga     1440

cactcacacc cacatacagt accaggatca tctgtccatg gttactgaat tttctttata     1500

atgacttggt tcaacgggtc cagtccacca tggacactca tttgtcccag acaagccctc     1560

tctctccccc tttctgggca gagaatgaag gtctggaaca tgtggttgct ctgtattcca     1620

caaagaagtg agttgctttt aagcctgggg tgtttcctag cgtagtagta acggcaggcc     1680

ggtcgccctg aatataatgg tgaacttgcc cttttggagt gcattacttg cttaattgga     1740

ttgggctgta attggtgcca tcaaattcta gagacagagg cactgttgtt tttccttccc     1800

gtctttgagc tggaagggta acagtgcaca aattaattaa tattggttat gggatttgaa     1860

catagaaggg ctttttattg agtagtagca tgtgtacctc ttacagttat ttctttagaa     1920

ctttctgaag agtccagctc aagcttgcca atgaaaacga atgacattta atggagcaaa     1980

aacaaaaaac aaaaaactat gttggtctac aaatatgaat ttgaagttat tgagagcctt     2040

gttgaataga tttttgttgt aaacgtgtct ctagaatagt atggcatagt ctcagcttcc     2100

tatgaatgaa ggacatacct tttctttttt aaaatatttg ttacacagga aagtgtgtct     2160

agaatgtgat ctgtggcaat aaattatgag agaccttcaa gagtttctga ttttggtagc     2220

cgagtgggca cagtttattg agaatcattt ttactgccat ttgttttctc acaagaatgt     2280

gcccaaataa tggttttttt ctcatttgga tggcagtgtg aattgtacat catgttttca     2340

gcatctttct caacctagtg ttccccagtc aagtttgaaa tctgtgttat ccaaatgaat     2400

tgttttcatt ttccttttct tagacaaagt gggactccag gtttcatttt gcttttaaac     2460

attttggttt tttgtttgcc tgttttgggg gcagttattt ctttcatatt aaaaagtact     2520

gtgcaggctg ggtgcagtgg ctcattcctg taatcccagc acttagggaa gcagaggcag     2580

gaggatcgct tgagtccagg agttcaagaa gtgcctgggc aacatagcga gaccccattc     2640

tctatttaaa acataaatgt aacccccgtt ccacgcacaa agtactgtgc aaattaatta     2700

aacatgacca cccagaccag caactgtcca agagtggccc atagaccatc tgtggtagga     2760

taatttgaaa tgcttgttaa aatgcagatt tgtagaccca gggatattct gacagagtct     2820

aaagtcttaa gaacaaaact gttctaaaca taagtcagta ccaatgccag ttaatttctg     2880

agatatattg atataactta gtttccagtt ttttaaaaac catattattg acttaaaaac     2940

catgatattg accagttatg tcagtaactt attttgcaca tctgtgtggt gtgtgagaac     3000

atgtgcagtc acttattcat tttgcctgca tttgttcata ttgggatcct cagattcaat     3060

gcactggatg tttgcactgg gtatttactt atactctctc tatttattcc gtctcatact     3120

tcgtcctatt tgttcatact ctcttatttg cccagcaagg tcaatgccag tttaggccta     3180

gggagtcatt ttttcttagt tgatatgact tagaaagctt gggagcctgc ccaacatcaa     3240

ttactttttt aaagctggta ttttctaggt cttgatattt attaagaccc tagcatagtg     3300

gacaattttt ctttctctca tgctttttca acacctcata gctcttcaca tttagttgac     3360

agagaattca gttatcttgc tgtagagtga cccatggtga ggaatctatg ccatggtact     3420

tttctggttc ttatccctta taggtaaaga caagtttctt atgtctgaag cttgatgtca     3480

ggatgagttc agggctttga tgaataagtt cagatctccc aattgtaatt cattagcatt     3540

gcacttaaaa aaatttatat acgtttttaa aaaagggtaa tgctaatgaa ttacaataga     3600

gagaaaagta cattagtttg catgtatgtg tgaaactggg aaaatttttc acgaaaatat     3660

tcatatactt tttaaaaaaa gggtaatgct aatgaattac agtagacaga aaagtatatt     3720

aatttgcaca tatgtgtaaa attgggaaaa ttccacacat acataaaagt atattaatat     3780

gcatgtatgt gtggaattgg ggaatgtttt ctcttcctca gtttctctcc cttgctttta     3840

atgtacagtc tttatgagcc attatttcag ctgtggcagt ttggttacca ggggaagcgc     3900

actagaaaat tgataaagga aaatgagaca aggtcataga ttctctcact cccttcaggg     3960

tacgtagatg aactatataa aaatccgtct aagtgggatt cgttaatcag caatttagtc     4020

aaatgtgtac atcctatgtt ctataagaaa tgtcagtggg tcctttccca agggagtgag     4080

atcatcagat gaaggttcat ttggtttcaa tgtcccgtat ccttttgtaa gaccttgaag     4140

ttggcaatgc aggaaaacag gaactccacc ctagctccat gaattgcaga actgttgtgt     4200

tggtttatga ccatctgccc attcttcctg ttatgacaca gcttgtgaac ttttactgag     4260

aatggtgaaa agtaaattcc cagttttata caatgaattg ctgaagaggc cttttaaagt     4320

atagagtatg cattgtttat ggaaggtgtt tcctattagg tctaactcag tggcaactac     4380

attcatttat ttaatttgtt tctaggtttg cctagtgttt ctcttgatct gcccaggctc     4440

agcatacaaa aagacatact tacaattaag gctaatacaa ctcttcaaat tacttgcagg     4500

taaggattca ttctagatct agatttcttg tgttaagtaa ctgattgttt attgagtgga     4560

aataatttcc agtagagcag aattataata gagcttgtag taattgttca taagtggtga     4620

ggtttctaag aactgatgta ataatggaaa atgagaagaa ttttctctca aaaattctgt     4680

acaattttgc tggtgttttt atactattct ctgccaacat gcatacacac acacacacac     4740

acacgcacac aaatacacac ccacacccac attccaataa ccagtacagc cacctggcgt     4800

atagtagaca tacgctcaat aaatatgaat gaataaatga agttgagggc atacatttaa     4860

ggaatagagt tgaaaaaatt tgggactata tttattatgc ttggtatgat tcttgaacac     4920

ttattatccc tttccaaaaa ctttgcttta taagaaattt attactataa ttacttaggc     4980

agtaatattt aatagcaatt taatatttag tgggtaatat tactgagcgc atgatctaca     5040

taaataatgg acttcgggcc ctgccttgat attctggaat gcatctttcc ccacttgcta     5100

gcaagaagtc atgctattga tttttgataa ctggagaagt agacttcttt gtcaagaaga     5160

agaggccttt aaattttgcc tttcaaccct taccccagga cgaaagatag aagacccttg     5220

ggtttaacat agtgatcaca cacgaaaggc atggagcctt cttaggacct gtgtgttttt     5280

ggtagagact gtgacaagtg gaggtgatgt taccctcctg gaagagtgct gggggtccac     5340

aaaggacctt gggtaggtta ttgccattgc ttcatacttg ttgaatacta agcattaaac     5400

cgaatgacat acatctattt tagactgcag tataaagaat accctagccc cttaccaata     5460

cccagccctt gggaaaaaac acagtagcag gtgctgtttc tctagcttta cttgtttaag     5520

acacatttcc cattagattt tccttttacc gaccctcgat aacaaggtta tttgaaatcc     5580

ccaaggatcc catgctccct ttttaaaact ctgcataaac atttcttatg ttctgaaaaa     5640

aaccatggag tgtgttaaaa gtaacttcat tgatttagct gcaacttcct ggaaatttta     5700

agttctttga atgaagggcc aataatgtta cattcttctt gatgttgact atcttcttat     5760

cttccttggg gccttgtaga gaaatgctgc agtacaagcc atctatgttt taatgcgagg     5820

tccttacaag gtcctgaggg actcttactt gcacctcctt ccttcctaac ctcacttctt     5880

actccccttt gctcactctt acctggctgc tctggtttcc tggctgttcc cttaatactc     5940

cagatatgca cctgctccag ggcctttcca tgtgctgttt ttgctcctgt aatactgctc     6000

ttcatgatgt tcctatggct agctttatca agaccacctc ctgcaaaatt ctttactctt     6060

ttctttgtat cttctatatt tttctccata gtactaaaca ctatctttta tacaataaac     6120

tttccttact ttttaattgc ctgttttctc cagttagact gaggttccat aaaggcattg     6180

atttttgtct gatttgttca ctgctctttc tctagtcctt aacaagtttg gcacatagta     6240

gatgcttaat agatatttgt tgaaagaaag aatgcattaa ttaatggaaa actcaggaat     6300

ctttataagt gacttctgaa gctgagttta taacttttca tcatatgtca atctgacttg     6360

ttggtagaag actttgtttt tttttttttg aggcagggtt gccctcttgc ccaggctgaa     6420

gtgcagtggt gtgattttgg ctcactgcaa cctccacctc ccgggttcaa gcaattctca     6480

tgcctcagcc tcctgagtag ctgggattac aggcatgcgc caccacacct ggctcatttt     6540

tgtattttta gtagagacag ggttttacca tgttgcccag cctggtctcg aactcctggc     6600

ctcaggtgat ccatccgcct tggcctccca aagtgctggg attataggca tgagccacca     6660

tgcctggccg gtagaagact gactgtgtct gttgaagagt ttatttaagt ttcaaaacca     6720

aattttctct tttcttagaa atagcctcac agtctggcac ttcatattaa tacctccctg     6780

aaattaattt ttcaggggac agagggactt ggactggctt tggcccaata atcagagtgg     6840

cagtgagcaa agggtggagg tgactgagtg cagcgatggc ctcttctgta agacactcac     6900

aattccaaaa gtgatcggaa atgacactgg agcctacaag tgcttctacc gggaaactga     6960

cttggcctcg gtcatttatg tctatgttca aggtaagtgg tgaaataaaa ttcatttccc     7020

acgtctcttt accagttata aaagacaata ggctcaaaga agaattgagt acaacaaagg     7080

gcttgctcta aaggctgttt gccaagagga atacacacaa ttcttctctc ctgaggcttt     7140

ctctgagaaa taagactcat tgattctgga gcttgggccg tgttacctct tttttgccca     7200

gttagtttgg gtctgatctt tgtttccaag gtaaatctgt gttcactgtt ggccattgag     7260

acttataaaa agtcttccta tgtttgagaa gaaaacctaa aattcttgaa atcgaggaag     7320

atttgggggt gaattatgga gaaatttctg tggagagata agttatctac agcagagtag     7380

gagattttcc caagaatgca taggaaagca ttttttgcca agggctctgg agttttttgc     7440

acataggaac ctttttttct tactagtatt tcataaaaaa caattcccat actcatgtgc     7500

aaataaagac attgcttcag actcttttca ggacaatgtt tctttccttt gcttgtttgg     7560

tctgagatct tggatgatat gctgtatctt tctaggatgt gcagtttggg attgatatta     7620

tgaaggctga cttaacatcc atatagtata aaataaatgt cacacatatt ctgcatttat     7680

aatgagttat gcattctttt gtgtttcaaa aatcttacac tatcttatct tttctgtgaa     7740

aacctaactt aactaatgag atccctatga tataaattta aggaatgtaa gggctgcatc     7800

atagtttggt tggatgtacc aaatattttt cttttcagtg aagataaaca gacattttat     7860

gtatttacgt atatgccttt ttacatccca gagtatttga gacaggtgaa gatgacttag     7920

acttttttcc cagaagcagc ttttacaggg caagaatttc atcagctttg ggaaacacac     7980

ttgcatatct ctgcttacat ttcagtagtg taatatggtc agtgcaatga aaaagtggag     8040

accacatcaa aataacctat gccactggat tcacaatgtt tgagaaatat ctttgcccag     8100

agtaagcact gtcaaagata gaattctgtg ccctcctcct tccctccaca agatttgaaa     8160

gagacaaggc tcacatcttg gagaatttct ggctcctttt gacctggcag tcttgagaga     8220

tgcagctcgg tcagaagatt gcaaggattt cctgctttca gcctgtctag aaatactaca     8280

agatgaacat cccccatatc tcattattta cttcttccta agtcaggaaa cttggagaca     8340

tgtgaaaatt catttcatga gtttcagtaa atattttatt ttgagaggct gggtggtggt     8400

ttgggtttct tttgtttatt tccttttttt gagataccga aatagaattg atttactaaa     8460

taggtttagt cttacgtcaa agggttaatt tagcttccaa aggcttgctc tgtaagcaag     8520

ttatgtaata tttcataaca tgtggatgaa aggtaggcaa tattaagaag tggcaatccc     8580

tagcactgtt tattggtaca ctgcctgtct ttgggtatac cattaaattc tgcttcctgt     8640

ctaagcttaa agttctagga gttgggctgt ccaagatttt ggccatgaag ttaaacaatg     8700

ggaaaggaaa cactgaagta ttctctatgg ataggtgttt aatgtcccct ctggtcgcca     8760

ccttacttcc ctagtcttct gaccccattc tcttcagcaa tggatggagc caggaagtga     8820

gccctggcct cataagataa tggctatggc atgtggtggg ctagattggc tgcttttctg     8880

tgctttccag ctgggaagga aatcaaactt ctgctgttgc agggaattag ctgcctttgt     8940

cccctgtggt ttaattaact ctttcttcac tttgactgac tattatgaag cactctgaga     9000

atgcttgatg ggatgtgttg ggcatagcaa tgtgaaatgt tatctctctg agatttcaag     9060

catgactcca caccacatca tctctatctc tgaggaatgg actaggtttc cagcagcatg     9120

ttaacattgt atgagtaatg tttgattggc cttgaaatct tttttttttt ttttttttga     9180

gacggagttt tgctcttgtt gcccaggcta aagtgcagtg gtgctatctc agctcactgc     9240

aacttctgcc ccccggttca aatgattctc ctgcctcagc ctctgaaata gctgggacta     9300

caggtgcgtg ccatcatgcc tggctaattt tttgtatttt tcgtagagat ggggttttgc     9360

cacgttggtc aggctggtct caaactcctg acctcaagtg atccacctgc ctcagcctcc     9420

caaagtgctg ggattacagg cgtgagccaa gaacccagtc agaatctctt cagttttctt     9480

ctcagtcttt ggagtggtga cttttcaaat gtttgtcatt gaagatatca atgactgcta     9540

aatgttaaac taaatgcaaa aacaattaaa catggtttta gaaagaatca tatccctagt     9600

cttcagaatc ttaaaatgct cacatgaatg gtcctcttga ataaccaaat tcaaaagtgt     9660

tagctgtttc ctgttaatct aaagatcctt tgggatccat tcatttattt tcatggaatt     9720

tacattattt acctaaagag agagcacatg agtattttaa atattagtaa aacttgtcgg     9780

taaagtgtat agatttaact ttaaatttta aagtaaatat tatccttcat tttgaaaaaa     9840

ttataatgat taatctttta aaatgtgaaa tctataaaaa tatattctgc ttgtcaataa     9900

accttgtgaa aggagtcaat ctcaattggg agtttttttt caaaattttt atacacacag     9960

atatatacac atgcatgtgc atgcacaaac acacacacac acatacacac acaccctcat    10020

gtagcacaga tatctatcag cagaataatc tgtggatgcc tttggttgtg tgaggtgtcc    10080

cttccagtca ttcacttgtc tggttagagt ttaggaacct gaaaaatgac caacttttct    10140

agtaaatact attaactcat taataaaact aaattttctt ctagattaca gatctccatt    10200

tattgcttct gttagtgacc aacatggagt cgtgtacatt actgagaaca aaaacaaaac    10260

tgtggtgatt ccatgtctcg ggtccatttc aaatctcaac gtgtcacttt gtgcagtaag    10320

ttgcatctcc tccaatcgtc tcttaagttt ttataatttt aagctaatat taagatgggt    10380

aacctgttta taatattcac aatgagtttt aaggatcctt taggaagggt caaatgcaat    10440

gaataaaact aattagtatt cttaaaaata agatgaattc ttcagtgatc attgtacatg    10500

gctctcattt ttggtactgg attaaatatt tgatatgtct ttttattacc cagagatacc    10560

cagaaaagag atttgttcct gatggtaaca gaatttcctg ggacagcaag aagggcttta    10620

ctattcccag ctacatgatc agctatgctg gcatggtctt ctgtgaagca aaaattaatg    10680

atgaaagtta ccagtctatt atgtacatag ttgtcgttgt aggtaagagg acatttcctt    10740

tccatatcat taataacata tccttgtatt aagatcttgg agataacaac atagagtgaa    10800

gaaggatatt gaaaagtata ggaactcagg atatggtgtt gggcaattca tctgctcttc    10860

tctaccaaat aaacccatgt gcaattgagg ttgtctcttt tcttgccaag attaaggaag    10920

aaaaagaaaa ctttttaaaa aaaggatgaa agcgaatggt attactcgag cacattttat    10980

gaagaattca atgttcagag cattgcttgc tatcaattat ttcaattatg actattttat    11040

ggaaacttca gcaatttgct aaagctggcc ctactggcct agggctactg accactgaaa    11100

gtttactact tttctgtcca ctgggttaca acatctttga gatctgtgaa ggtagtgctt    11160

tgtaaacctc tgttggccat tttcctggga gctaccaagt attggtgagg cctgcaggga    11220

aaaacaatgt ggcatgtttt aaagttgcat tactttaaaa aataaatctg tgcaaagtta    11280

taggcttatt tgctctctca tgttctgttt tttcaattta cttgctctag ggtataggat    11340

ttatgatgtg gttctgagtc cgtctcatgg aattgaacta tctgttggag aaaagcttgt    11400

cttaaattgt acagcaagaa ctgaactaaa tgtggggatt gacttcaact gggaataccc    11460

ttcttcgaag gtaacgctaa tgattcaaag ccagacctcc aaatacttag ataataagcc    11520

ccagtgaagt ttgcttgaga gataggggcc tctttggcca gataaaatgt aagagcctta    11580

aacacacaca catacacacc cactcacaca cacatacaca cacacacaat ttaagggaat    11640

tgcagaacag atagcaccca ccaaaaggtg aaataccagg aattttgtcc tattctgcaa    11700

tagccaggct atgaatatta gttttctcta ggtgattaca tctttccaca ttatgtcatt    11760

tctctgttct ccaaagtttt tgatctacat tccttttaag ggaatttctc tttaagaggt    11820

ggcatgagat acactgctcc ttaaacagtg gtcacattta cttgtgtttc tgcagtttat    11880

atccatctca ctttcaccac gtgaggtttt aaaaatccta attcagttgg ttccatttat    11940

ttctcctgaa acaaaatata tttgttgtct gcatgaggtt aaaagttctg gtgtccctgt    12000

ttttagcatt aaataatgtt taccaaagcc cagatttaat tctgtgtgtt actagaagtt    12060

attgggtaat gttatatgct gtgctttgga agttcagtca actctttttt tcagcatcag    12120

cataagaaac ttgtaaaccg agacctaaaa acccagtctg ggagtgagat gaagaaattt    12180

ttgagcacct taactataga tggtgtaacc cggagtgacc aaggattgta cacctgtgca    12240

gcatccagtg ggctgatgac caagaagaac agcacatttg tcagggtcca tggtaagcta    12300

tggtcttgga aattattctg tgccttgaca agtgagataa tttaaataaa tttaggtcac    12360

ttagtgattc ctattttgtt cattcagaag atagtttcta gtttttcttg ttagggaggc    12420

cacatgacct agaggtcaag agcatagctt tgtagtcagg aacttgggtt caaacctcaa    12480

ctttaaagat gagatgtgct gatatacagt aagagttcat ttagtattac ttattatagt    12540

tattgctgct attaggattg ttactatgat aaatagtatt agctaaggta gtttttaaat    12600

tttcatttta ttgcaaggct gagaggccta cttgaataag catgagcttt gcaaactggg    12660

gaaacattta gcaatataca gttgacctgt gagcaactca gggattgggg gaactcaggg    12720

gagttcccct aactttccct cctctgcagt caaaaatcca tgtataggcc gggcgcggtg    12780

gctcacgcct gtaatcccaa cactttggga gtctgaggtg ggtggatcac ctgagatcag    12840

gagttcgaaa ccagcctggt caacatggtg gaaccccatc tctactaaaa atccaaaaaa    12900

ttagcctggt gtggtggtgg gagcttgtaa tcccagctac tcaggaggct gaggcaggag    12960

aattgcttga acccaggagg tggaggttgc agtgagccaa gatcgtgcca ttgtacccca    13020

gcctgggcaa caagagtgaa actccttctc aaaaaaaaaa aaaaaaaaaa aatcaaggta    13080

taacttttga cttccacaaa acataactaa tggcctactg ttgactggaa gccctactga    13140

taacataaac agtcaattaa cacatatttt atatgttata tgtattatat actgtattct    13200

tccaataaag ctagagaaaa gaaaatgtta ttaagaaaat tgtaaggaag agaaaatata    13260

tttactattc attaagtgta agtggatcat cataaaggtc ttcatccttg tcttcacgtt    13320

gagtaggctg aggaaaaggg ggaagaggag ggggtggttt tgctgtctca ggggtggcag    13380

aggtggaaga aaatctgctt ataagtggac tcatgtagtt caagtttgtg ttatttaagg    13440

gtcaactgta attgaactgg aattaaattg aactggcctt gagaaaatca ccttaatttt    13500

ttgtttattc tctttcattt acataaatgt ctgagtttac atggtaattt gtgtggcatc    13560

ctacttataa gccttggaaa ggattttgga gtttatatta tgagaatgca tcaatacagt    13620

gaaattttaa aaatacctta gataatgcta tttattagag ttgtaatcat aaaagtggca    13680

acaactataa caagtatgat ttagtgagca cttactttat tagctcatct catctttgaa    13740

gctgagattg gaactcaagt tcctgactac aaagctatgc tcttgacctc taggtcacgt    13800

ggcatcccta gcaagaactt gaaaatttct tctgaatgaa caaaatagaa atcactaagt    13860

gtcctaaatt tatttaaatt atttcacttg ccaagatgca cttgtcaaaa tacacagaga    13920

gagatgtgct ctggcttatg tttttataga attacttttg ttttccagaa tacttcaggg    13980

aaataggggc agaaataagg aggtcagttg ggaggctaat tgcagttatc caagtgagag    14040

ttgaggggtg gcttagacaa gggtagttga ggtggaggta gtgagaggtg atctgcttct    14100

ggatatattt tgaaggtaga gtcaacaggg tccgctgatc aattcattgg ttgtggagta    14160

taagagaaaa agagtggaag atgactcgag cgttagcatg agcaactgag taaatgatgg    14220

tgttatttac tgagatggca aagatcgaga aggcagtgag atttagggaa acagtgttag    14280

atatgtttat ctggagatgc ctgttaaaca tccaagtgga gatatttaac atatcaaccc    14340

ggaacccaga ggagtcaggg cagaagataa cacatttagg aggtacgtga atgatacttt    14400

aaacctgagg ctagaggaag gtgtaaataa agaggaggtc tgaggactga gtcctggggc    14460

ctcatggtgg aagaggtgtg tggaggctgt catgggagca gaggagaagg agcacccaag    14520

catccctggg ggacttagag aaagctgcac agaggagcaa gtgtttgagt tgagacttga    14580

gcaatcacta ggcttgtggg agtgcactag cggggagaga aaagcaaatg caaacacagg    14640

aggtgtggga gaaacacggg aggtgtggga gaagctgaaa agtgacccac tgaaagatag    14700

tacaggaaat cttggaactg cagctactca gaccctcaag gtctttgacg tttcacttga    14760

aatgaaaaac taaatcaaat gaccatttac agtaagttga cctttttttt tttttatttt    14820

cttccagaaa aaccttttgt tgcttttgga agtggcatgg aatctctggt ggaagccacg    14880

gtgggggagc gtgtcagaat ccctgcgaag taccttggtt acccaccccc agaaataaaa    14940

tggtaactac tggaaataaa tgcaaagcat catttcgtgt gagagcaaat cctttgacta    15000

tactaattcc tgagaatttt ttttcatagg tataaaaatg gaatacccct tgagtccaat    15060

cacacaatta aagcggggca tgtactgacg attatggaag tgagtgaaag agacacagga    15120

aattacactg tcatccttac caatcccatt tcaaaggaga agcagagcca tgtggtctct    15180

ctggttgtgt atggtgagtc cattcaattt tcctctctgc ccaagattta ttatgataca    15240

ttgtcttcca aatcagccaa accaccgttc ctctgcctcc tgctgcttca ctcatatcat    15300

ggctgggcct gcgtacaaaa gtcatctggc gtggtgaagc tgaagtgaaa cgtaggacca    15360

tgtgctctgg ccatgtttgt ttaagaggcc gtgtaaatga gctttgtggt ggacaaatgc    15420

aagattaaag tagtgatacc ctcgatagct aaatgttgtg aaataagaat gcccacaggg    15480

acagttgtca agctaagtta tactaccatg ttcccctctc atggaattgc ccacctggta    15540

cacagatgtg taagaccctt ctccttagat tttgtgcaaa gcttctagtt tgatgttgta    15600

gttgatgtat cagagatgtg caggcacgtt ccaactctga aggcttttga agttgacact    15660

gttggcttgg ttgggagctt ttcttttttc ctttttgaca ggagttcagg atctgatttt    15720

gagtctgtaa aggaaagata gtaagttttt gatgtaaaga taatttgaac tttgttttct    15780

gaaactgaaa ggtacaaata agtgtttgga atggagtggg gagaagggtg ccatggtcaa    15840

gtgagtgtga gaggtgctaa ggtgatgtgt agatgtgtaa caggtttctt tattgcagga    15900

cttcgcagaa ccttttatat gctaatgtat attggtattc tccaggagga gagacataga    15960

gtattcaagg tttaacaaac ctatttgacc agagcacctt ttttcccctg agcaaattca    16020

ttaatctctc actccaaaca gtttgagaaa tgcttctctg ttgtaattct ttgttccccc    16080

ttctggtacg gcatattaaa acttcaggat attttcccat gacattaagg tgcttcccta    16140

cgtgtcctga tactcttctg taggccgctg aacttggctt tattattttt tttcagggaa    16200

tattttaaag ataggctggg tgccgtggtt tgcatctgta atcccagcac tttgggaggc    16260

cgaggcggat ggatcacctg aggtcaggag ttcgagacca gcctggccaa catgatgaaa    16320

acccgtctct actaaaaata taaaaattag ccaggcatgg tggtgggcac ctgtaatccc    16380

agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggtgga ggttgcagat    16440

agccgagatc gcaccattgt actccagcct ggtgacaaga gcaaaactcc gtctcaaaaa    16500

aaaagttaac aggttccaaa aaggttgttt agaagcagca taggtgtagg ggactgggga    16560

gaggagaaac tggaaagtgt ataagtagga tgggaggagg aaatgaacag gaaataaaaa    16620

caaaacacgg acagcaaata gcccatttca tcagttcatg aagccactaa atattttatt    16680

cactttagca aattctctgc tatatgaaat aaacataaaa aagaagtcaa gtcttcaaag    16740

cataatctga ggctttaggt tgacagtaat aaggaaatag ttttgacttt ggagtcaaaa    16800

aagaaagaaa ggaaaaaggg agagaagaaa gaaggaagtg agagaaggga gaaggaagaa    16860

aggggaagag ggaaagggag tggagaggga gggagggagg aagagggaga gagaatgaaa    16920

aactcagatg atggtggcag gaatgcattc tctaaagatt tacaccttcc tttaacatga    16980

ggtggtttac gtgtttgggt tcagaagtca gagtgtctag gtttgttcca ggttttgccg    17040

ttcgttaact gagtgacctt gggcgagtca tttttttctg tttcattttt ttctcacgta    17100

taaagctgtg gacagtaata gtggttgtga ggattaagtg aatgaattca tgcaaagcac    17160

ttcaaacaat gcttggcaca taataaatgt atttactgtg ctatttcagc tgttttctgt    17220

agcctttccc tgatctccta aacttgagag gacagagaga actatctctg taatacagat    17280

gagaggcaca ggatttcaac acttccataa agtcattcag cttgttagtt tattattatt    17340

attagcttat tgtcattttt attttatttc gttactttat tccttttttt tttttttggt    17400

agagatgggg tctcaccatg tggcccaggc tggtcttgat ctcctgggct taagcgatcc    17460

acctaccttg gcgtcccaaa atactgagat tacaggcata agcccccatg cctggctagt    17520

tgttattttt atgagtatca ctagaactca ggtctcttgt ttccacatct aggtgttctt    17580

cgaaaaagaa agtggaagca aaatcatatg cttaaagaaa gtcagcttta gttgctaaaa    17640

tcctctattt cccattcttc aaagctgact gacaattcaa aagttgtttt tcccatcttc    17700

agtcccaccc cagattggtg agaaatctct aatctctcct gtggattcct accagtacgg    17760

caccactcaa acgctgacat gtacggtcta tgccattcct cccccgcatc acatccactg    17820

gtattggcag ttggaggaag agtgcgccaa cgagcccagg tgagtaaggc cacatgctct    17880

ttgctttcct gccatcttgc atttcttaca gctgagctat gatatgactc catcctaaat    17940

ggagaagcct aaaccaaaaa aagttttctc tcaagaggta gcctgaatct ccatccatct    18000

ttctctgtgt cttacatttt aggggatgtc tttgcttgga gtatcctcct ttggggttag    18060

ctaagctcag ccttgttagg ttagccgtga ggtacacttc tccaaacaca ggctatttgc    18120

tcagtttgct aattgccagt ctttggtttt tctcccgata ccaatcggct ggtgaatacc    18180

acatccctcc ttcttgtgtg tgtgaagatc catctctcag aggaaatgct gatagatgag    18240

aggcagtgat agacccagcc ccagtcctca gggtctcagg cccagcttat catgctctga    18300

cacaagtcca gacatcctta gggaaaaaca caacaacagc agccaaccca ccaccaccct    18360

aagcagtcca cttcctgttg ttgtttttga aatggccact atgagcttct tcctcagctg    18420

ctgatcattt ccttcacaga gaccatggtc ccagagaaat tactttaagg agcccagtgg    18480

cttctaagtt tccttgcctt cctttgaact aaattaactt gaattgtctt gtcgatccaa    18540

tttatgaatg aaggtttatt cccagaatag ctgcttccct cctgtatcct gaatgaatct    18600

acctagaacc ttttccttca ttgtcaatgc ctatttttaa ttggcgccaa gtcttgtacc    18660

atggtaggct gcgttggaag ttatttctaa gaacagaata accaaagtct gaatcttttc    18720

cttactcttg actctaatta aagaaaaatt aaatcataat atgcgctgtt atctctttct    18780

tatagccaag ctgtctcagt gacaaaccca tacccttgtg aagaatggag aagtgtggag    18840

gacttccagg gaggaaataa aattgaagtt aataaaaatc aatttgctct aattgaagga    18900

aaaaacaaag tgagtttgaa gttttaaaat ttgaaaatct ctctctcttt aatggaagga    18960

tggtacaata atatgtgagg catattggag attaataatc aaatagtctg gatgattaaa    19020

tagagcgtat taagtcactt tgaaaatacc attgactttt agcagtacca ttaacttatt    19080

aatagcttat cagagaaaaa taaaaacatc tatgacatta aatctatgca tctgtgtagg    19140

gtgattctga ttttataaac atgagaatga aaaaatgtgt atcatatcat attaaaacac    19200

atcattagtt tcatggcttc caaagccctt tttatataat gtgtgagctc cacagcagca    19260

taattataca aattgagtaa atatcccaaa cctaaaaacc ccaaatccaa aatgctccag    19320

attctgaacc tttttgagtg ccgacatggt gctcaaagga aacgctcgtt ggagcatttt    19380

ggattttcag attagggatg ctcaactggt aagtatacaa tgcaaatatt ccaaaatcca    19440

aaaaaaaaaa tccaaaatcc aaaccacttt tggtcccaag cgttttgagt aagggatact    19500

caacctgcaa ttgcataaat ttgagcgtgt ccaaccgctg cagaagtggg aatggcatag    19560

gcaggttgga gtgattgtgg agactgctgg actgagtgct tgtgcacaaa cagccgcgtt    19620

gtttatggcc tgggatttgt tttttccccg cacagactgt aagtaccctt gttatccaag    19680

cggcaaatgt gtcagctttg tacaaatgtg aagcggtcaa caaagtcggg agaggagaga    19740

gggtgatctc cttccacgtg accagtaagt actcttctct ggaggtttgg gttggatcac    19800

tcacacagtg ggtactaagc tatgtaattc cctgttgttt ttgccattca tgtgagtggc    19860

atggcattta ggaaagagga cttggattga tcattgatgc tttcattcat aaattacaac    19920

ttctcaggta tctcctgggc ttatgtgaag tcagtgcgtc taactacact ggagagagaa    19980

tggtttcaca gatgctttaa accacaagct ctgtgtggta tttacatctc agtcttcaga    20040

gtctggcaca gtgcctggct tattgagctt cagtacatat tggtgggctt gctgtggaac    20100

agttgatgag ggtgggcttt atggaggcaa tcagaaggac ataggagcag tgccctccca    20160

atgctgccga ttttgcctgt gcatcttagt tttatggata agctttagct gattgtgctg    20220

aatggaatat tatagccagg gctaattcat tggcataaat gtagctttca tatcattgag    20280

tgttagtgtt aatgaagacc taattttaaa attctgttag aattagagat tttgctttgg    20340

atttttaata tattaaacat tgcgtagagc tcatagtgga gatgtggtaa atatctgagg    20400

aattcgttta cattttcaag taatgtgttt ggccaaataa gatattttgg gacctgaatt    20460

gtctagtttg tttgtcaagt tgtagtacat cacctggaac ggatagagct tcatttcttt    20520

tggtactttg tagtagtctg aaagcagcaa gatgatagtg agctgtacca agttaaatca    20580

ccattcaata actatggcct cttcatttta gggggtcctg aaattacttt gcaacctgac    20640

atgcagccca ctgagcagga gagcgtgtct ttgtggtgca ctgcagacag atctacgttt    20700

gagaacctca catggtacaa gcttggccca cagcctctgc caatccatgt gggagagttg    20760

cccacacctg tttgcaagaa cttggatact ctttggaaat tgaatgccac catgttctct    20820

aatagcacaa atgacatttt gatcatggag cttaagaatg catccttgca ggaccaagga    20880

gactatgtct gccttgctca agacaggaag accaagaaaa gacattgcgt ggtcaggcag    20940

ctcacagtcc taggtaggga gacaattctg gatcattgtg cagaggcagt tggaatgcct    21000

taaatgtagt gcaattcagg tgctatgcaa agattactgt cctctaggag attatgttgt    21060

aaactggtgc acacttcttc accgaaagtc cttgaggaag aaagaagcta ataataatga    21120

aatgatatat cgaaaggaga aaataacaaa acctgatgat ggagtaattc actagtatat    21180

gcaagggata ttagcttgaa ccagggaaac ttctgcctta tcttgggcat ccatttattt    21240

aaatagacaa atatttgtgg aatgcctgct atgagctagg agagtgtcag aaattcacag    21300

tggtaaacat gaaggaaagg aggagaacat aggcaaccac tgggaagtca cagcacagtg    21360

aggtctctgt gtccatgaga acaggaattg ttctctgttt tgctccctgc tatagctcta    21420

gtcatagagc atagcagcat atactaactg ctcaataagg cacctgctgc atgaagagtg    21480

ggatgatggg ctgcgtttaa gacctagaag actccatggg aaggaagcta cattcactgt    21540

ctgtacctct gggtcatccc acatgatcca gcgtagccca aggtcaatgg gacgatcact    21600

tcagtgagca gatagctctg taaattcctc catagaggca ctgtctaccc cttgtctaac    21660

ctcatgcctt gtgcaaaagc tgggcagcca tggctttgtc tgtgggaaaa tcaggcaaat    21720

ttggggagcg tctctttgtg ccacttctct ccattttctc ctcttgtggt gtccctttcc    21780

aattcctagg atatatgtgc cctctgtttt ttttttactg ttaggaagga aattgcccaa    21840

gtaaattcat ctataccaca gttttagagg gtaacgtctt catcagaggc cttggcgtat    21900

ttgaagaggc accttctgac agacactagc ataaagttcg ctagttttaa gactcaggtg    21960

tcataataag agatactttg gggtcaagtc atccccagca tccttcaagt cacaccacat    22020

agatcacatg gattttctgt tggcttgtct ggcttcaagg ttatggcaga attgagaaag    22080

agatgtgaag taggctcctg gcctagctgt gcccagaaaa tatgtgctcg cagttagctg    22140

ctttgcttcc ctaaggactc ctaacttgtt ttcctaaaac ctattcttag aaataggcta    22200

gaatccagta catttgctta gacttcaatg tagtacgctg ttgaggtaat ctcattttgc    22260

taagtgttga cgtggatttt ttcagcatga ttccttttga tgttcagttg gttgggacaa    22320

gatatttcca cagcactttg atgatctgaa gaaagaataa atctaaagtg ttcttgtaca    22380

cttaaacaaa tactcatggg cttcattttc tttaaatcca agacttccct tagggtattg    22440

ttgttttgtt tgtgttttag tggaaatagc actgaactgg tcttttagcc tcaccagatt    22500

ctgtaaacag ttcaactgtt tacttagttg cagggacatg gacaagtggt ttaatgtcgc    22560

tgaacatcat ttatttcatc tgtgagataa cgctaacagt cctattctgc tcattacata    22620

agatcactag tgaggaacac aaattgtgta aacaagtttt ataagaattg ccaaataaat    22680

gtaaggcatt attggttgaa tgatactaaa atttggcact tccaagagaa atttgaaggg    22740

attctagggt attattgact agaatcttca tgggagggaa gttttcacct ggggaggctg    22800

tgtctaatta gaggaaaaat ccataaaggt gaccctgaac ctttcttttg tgatgggatt    22860

accagctagt atcactaata tgaatgttaa aagccattaa tctgtttgca gtgtcctgac    22920

tgacttgttt catttaactt tacccagtga ccagtgtatt ttcccagaag ttaatatatc    22980

aacaagttcc tttttactaa atttaaactg tttaaaagtt tgctgatacc agaaccattt    23040

caaaagttat aattccatgt tctgtgattt tctttttgtg tgtctagagc gtgtggcacc    23100

cacgatcaca ggaaacctgg agaatcagac gacaagtatt ggggaaagca tcgaagtctc    23160

atgcacggca tctgggaatc cccctccaca gatcatgtgg tttaaagata atgagaccct    23220

tgtagaagac tcaggtaaat agaatttggc tatcactctt gggttgcaga actttcccag    23280

ggatgttatc taaaaagcca tattatttct tgatgtaatg tagaaaaaaa gcagtattgg    23340

tgtccatgac ctggctcatt tcacagactt agaattggag tatggggccc tgttgaattt    23400

tcatgaaagc catataggag attagtcagc agtagatccc atgtgactct acagagttag    23460

ataatagaac aagatgaagg gcagcattta tattttctaa atttccctga aaaacttcac    23520

agactacatc atcataaatg agaatgatcg ttttcttcct ctgttaggca ttgtattgaa    23580

ggatgggaac cggaacctca ctatccgcag agtgaggaag gaggacgaag gcctctacac    23640

ctgccaggca tgcagtgttc ttggctgtgc aaaagtggag gcatttttca taatagaagg    23700

tcagtgggat aaaaaaaaat gtggtacata tacaccatgg aatgctatgc agccgtaaaa    23760

aggaatctga tcatgtcctt tgcagctgca tggatggagc tggaagccat tatcctcagc    23820

aaactaacac aggaacagaa aaccaaacgc cacacattct cacttataag tgggagctga    23880

acaatgtgaa cacatagaca cagggaaggg aacaacacac actggggcct actgtgggtt    23940

ggggagaagg agagcatcag gaaaaatagc taatgcatgc tgggcttaat acctaggaga    24000

tggattaata ggtgcagcaa atcaccatgg cacatgttta cctgtgtaac aaacctgagc    24060

attctgcaca tgtatcccgg aacttaaaag aaaaaaagaa ggtcagtggg aagtcataga    24120

tacatcctgt ggtttttgaa gattagtttg tatcttatag acacacattc actttgaata    24180

gggcaacgac agatgatttt taatattctt tgtactttgt aaattttctc agtgagtatg    24240

tattctttta accagcaaac ataattaatg ttgttataat tctgcttgca tcacatttcc    24300

tattcctgca gttcttattg tggaaaaatt cttaatcagg caggatgaat agcctcttct    24360

ccctgattct gtctttgttt gaatggcttg attaacttat agaaatgatg cctttatatt    24420

tatttggaaa aacattagaa ttgctgccta atcatggcag tcaatgctat ccagatagtc    24480

acaaggattc cgagttttaa ttggactaga gataattaag attcacttgt gaacaataga    24540

ccattgctct tctgacatgg aaaatttttg gtttttatct caatacgtgt gtatgcagaa    24600

gtgatgtgaa atctgtcatt ttcttagcta ggaaaagtaa tttgtggcag aatattttat    24660

cttaagaagt atattcctat ggcttttttt tttatagccc accagggaaa gaataaaact    24720

gtgttgtggg gtaaaagaat ggtatgcaag ggtaagaaag aagtatggtg atagaaggga    24780

tcgatggatt tctatgaact catcctaact tgtctctcaa agtctagatt ttggtccctt    24840

tactctgcca aatctatgat gccaagtatt gcatcgagat atgttgacat attttcaaat    24900

gtataagctt attagcattt cataaactac acttgcaaat aaagatttca aagaccatgg    24960

cggttttgtc atttccaaag tgattcatgt tttagggcaa atccgcagaa tgacgtctag    25020

attgtctctg atgctctgca ttacctcttg ttggtggcct gcagctggtt acagatgcct    25080

aactaggtaa cactggcaca gagattatag ttacttctta cctggagtga atgctaagaa    25140

aggcagagct agatatttaa tactcctgct gggttcccaa atgttatgcg agaatattaa    25200

tatacaaaca catagaaaac agactctttg aactttttat cctctatgtt caactggact    25260

tttaaatctg tgtgtataaa tagagaatta cttccctagg accaccagag aaacaaaatt    25320

tactccaagc ataattgtgc ttgtctctca atggttaagt taacttttat tttgcaaacc    25380

aatttgttac ttattttgca aaccagtttc ttacttgtct tcttctctct tgaggccgta    25440

gtgggccatc cgcacagctt gtggcccggt ttgattctcc ttgcactctt ctgatgggag    25500

gccccaagtg atgactgctt ccttatcatc tctttgctaa tcactcttag tggaaagcct    25560

gtttctgtat tttgtttctt ccactcagag ctgtcctctg aagccctgag catctgcagc    25620

tttgcttgct gacttctagt ttcctcttct ctttcctttc atgagtgatt tgaaactccc    25680

attaccaggc catgcgtgat gtgctcatct tggctcttcc tcttctcctc actcagactc    25740

ctgccacaag ggatggggta gtgtatgtaa tggttagttc atgttggaca ggcctcttta    25800

tctcttgact gaaccactga ctagctgtgt gccctcagtc aagtagctta agctctctgg    25860

tcttctgttt cttcatctga aaactgagag ttgttgagga gattaagtgg aatggcatat    25920

ttaaagtgat gagtgcatag tagatacatg gtcattagta actctcaggt caaaaaattt    25980

tgtttatttc cctacttggt ttcttatgtg atccttttgc aaactctgca cagatcaaaa    26040

tattgactat cagtttaaaa gaagactttt gttttcctca aatagaaata tttttttttc    26100

tctgtagaga atgatctgtt ttctttccat caaagactgc tcttcctcta aacactttct    26160

atgtttggct tttaagacat tactacttct atgcttaatt acttaagaat tttattgttg    26220

taagtttaca tgagcaatgt tttgcaagct ttaaattttc cattaacaat tctgtaggcc    26280

aggtgtggtg gcttatgcct gtaatccctg cactttggga ggccaaggca ggggggatgg    26340

ctagaggcca ggagttcgag actagcctgg gcaatgtagt gagaccctgt ctctacagaa    26400

aataaaagaa aaattagctg ggcttggtgg tatgcacctg tagtcccagc tactcgggag    26460

gctgaggggg gagaatcgct tgagcctagg aattggaggc tgcaataagc tatgattgtg    26520

tcatggtact ccagcctgga acatagaaag aaaccctgtc tctaaaaata aataaataaa    26580

taaataaata aataaataaa taaataaata aattaaattc aaaaaaagaa ttctgtagac    26640

tccattcaag ttacgggtgt gtaactgttg tcctctagga tttttccaag ttggtaagct    26700

tgggattttg ctttagtgct aaaatttgtc atcttacaaa caaaaagtat aagtttccaa    26760

ctgttgatac tcattcaatt gtgtctttcc aggtgcccag gaaaagacga acttggaaat    26820

cattattcta gtaggcacgg cggtgattgc catgttcttc tggctacttc ttgtcatcat    26880

cctacggacc gttaagcggg taaaaaaata atttcccttc tgcccatgca cattggtttt    26940

catgattaat gaaaactgac tggggttctt tgagttgttt cttcccattg ttattggctc    27000

aatgggcaca tttttatttc aatacaataa cgttcctgcc cactttcttt tggctggatc    27060

tcagggattt aattgataga agccactaga gaggaaaagg gcttggactg tctagtgtaa    27120

ttaagcttta aaaccttaat tctgagctcc tttgggggac aagggaaact agaagcaggg    27180

ttataatagg accactctca aactccatga gttttattgg aaaatgagac aggaatgagg    27240

ctccaataaa cagcaataac aagcacacaa aacaacagcc aaacaacagt gtgtttatga    27300

ctggaaggat tgatgctttc caggccaatg gaggggaact gaagacaggc tacttgtcca    27360

tcgtcatgga tccagatgaa ctcccattgg atgaacattg tgaacgactg ccttatgatg    27420

ccagcaaatg ggaattcccc agagaccggc tgaagctagg tgcattttca attgctatta    27480

atttgatatt gtgtttacca ggccatctct tcctccatta gaatgatgac aaatgtggtg    27540

tattcagatg ttggattctg gtttagaaat attaattcca tttcttgaat ttgtataatc    27600

attcatatag ccacttagag gtagggtccc tatgtaatca tccaaagcag gacatttgga    27660

gagtgaaggg ggagttatta aataattaag ccaggacaaa ggagtaaact ggactatcca    27720

tgttaaattg ggatgtatgg tcaccctatc tagttgatgt ctctgcgtat cactttggtt    27780

gtatagtaat ccaagtctgt tttcttgttg ctgttgttgt tgactctagg taagcctctt    27840

ggccgtggtg cctttggcca agtgattgaa gcagatgcct ttggaattga caagacagca    27900

acttgcagga cagtagcagt caaaatgttg aaaggtaaaa gcaaaattat gtggtgatct    27960

atctttctgt tttatctagt ctttaaatat gttgcaaggc ttgtatcagt agctttgtgc    28020

ttatgtgggc ctactagcca cacatgcagt cagcctaaat aatgcccttg tgcaaattgg    28080

aaaaaggatc ctcctttgta gctttatgcc aggatgcatg gtctggcaag caaagttggg    28140

aatggctttc accttcttgc ctggttaccc tcgtgcaggg ctcagccaac acagttgtac    28200

ttagtggttc tgggtacagg gaaaaaggac tgtggttata ttaaaattgt ttcttaatat    28260

attgtggaat cagataatta tagaccatct agagacatgg aaaggaagat agtgaaatac    28320

aaaaatagca tgttctccag aattggaata tgtaaaagat gttcatatgt aaaagataat    28380

ttgcaaaaca agaatggttg tgttagaaaa aaatataatg ggttatattt tttaaattaa    28440

aagctttata aataattgtt aattctaata gtaacggaat tctggtctgg ccattttcat    28500

tttaggaggt tagacagtaa agcttctttc ttcaattgtg atgttctttc attgatgaag    28560

gcagtgccaa tgaccctttg ccaataggtt ttgtgcattt caaagctatc tttctccatc    28620

tgcctttttt ctcttgtggc caagggagtg tgtaattttg aggtggctca tcagagcctt    28680

agatgtggac catgcctgtg aattagtggg aagtgtagca gtccatacag gatcaaacac    28740

atagtcttag tgccatcagc ctcatgtgcc aactggtctt tccagctggc cttaattcgc    28800

ctgcacagat cggcacagat tggctggaac attcggtata gcccctaaca cgtgaagata    28860

tttaatacat ggtgttgctt ccttatgagg aagtgctgaa atgatcagac cctcagaatc    28920

atagtgaacc tgaaatgcaa aaatccagtt ttgcagaaga agagaatctg ggcatgattc    28980

cactgcagat gtattctccg ctttgcaaaa ggtttcacaa tgggttcctt taaatatcaa    29040

actttctggc tcacttaaaa tatgaatttt atttcaaatt agaaaataga atttacactt    29100

cacttttgag gaaatgcatg tggtctgtaa actaggtcac agctgtgtta ccccggaggg    29160

taagttgtat agtggcatgc agggagggag ggaccccaat tattgaagga aatgtccata    29220

cctatgattt ccctctttgt actgtatttg tagaaggagc aacacacagt gagcatcgag    29280

ctctcatgtc tgaactcaag atcctcattc atattggtca ccatctcaat gtggtcaacc    29340

ttctaggtgc ctgtaccaag ccaggaggtg agtaactgtg ggtggttttg gtcacccaat    29400

tttaacatgc ctctctgata gtgtttgagg gaaagcagtc aactcctctg gccttgattt    29460

tcttagctta gaatactttg cggattccta ggaataaata tatttcatgg aggtttaatt    29520

ggcactagaa ttaaattatt gtaaaacttt ctctgaatta agaaatgtca tgctactatg    29580

atacagtttg ttacttgtgt aacagatgtc cagagaagag taaacttccc taaaacttga    29640

aagcttaagg gtagttaccc ccaaaatgga atcatatcag gagattgcac tgaaaagcaa    29700

gtagatgggt gggttttctt ctgaaatttt ggttaatctt gtgaaaatgt gttctggaaa    29760

aaagaaaagc tacaatataa ggggattggg accagctgat ttctacactc ctgtcccaat    29820

gaaaggttgt agccttcttc taaggtgttt ttgggttcat cactatatta aacgcttagt    29880

gaggaatatg agtgaaaacc cattttcctt cctggacatg ctgcctgcag ggccactcat    29940

ggtgattgtg gaattctgca aatttggaaa cctgtccact tacctgagga gcaagagaaa    30000

tgaatttgtc ccctacaagg tatgtcatct cctaatcctg ctctggccat gttataaaat    30060

gaagggaaac tcaaaatggt acaggttagt tttttagttg aaattttgtg aagaacttgt    30120

gaggaatctt ctcatattac ctcttggctg ttgtaacttc ctcttttacc ttctgggggc    30180

catatgtttc tgttttatgt atgtgatttt aatctactga cccattacag agtgtggaca    30240

tgggggagaa ggcaggtatg agcgaggaaa ggggagggca gagggtagga catctctggg    30300

ttattctgtc tctcccctag ccatatttgg ccccgtggag tgtaaatccc tctgtgaaga    30360

gcatcctaat gctgaaagtg tgtctgaatg caactcaaaa tgtggcattt gtcactttaa    30420

gctaaagaag gagctaggct ttgtggaaga aaccctatta tgcacaaaac ttgccccaag    30480

tttcagctca gagattgcat aatcctgaaa ttgatgtcct ccttgtctgc tttttagtag    30540

tttcaattat ctccatggtt tactacattt taaaggttgt aaacttttaa agactcattt    30600

tgtattcaag gagtttgttt gttcctttgc ttttttatag accaaagggg cacgattccg    30660

tcaagggaaa gactacgttg gagcaatccc tgtggatctg aaacggcgct tggacagcat    30720

caccagtagc cagagctcag ccagctctgg atttgtggag gagaagtccc tcagtgatgt    30780

agaagaagag gaaggtactg gctagtgctt cctgcatgct atggcatgct cttgtcagag    30840

cagacagggt gatagggtgt tacaaggaat ttgatcatgg gaaaagtcca atactacctc    30900

ataatttgaa agagacctga atttctataa tagactgcct ccattctgtc tccccaaaag    30960

tgaagtgtgg aagccctaga ctgggaagtg aagcagggct agcctgagaa atctgggtag    31020

tccaagtggg ctaagcagtc ggctacaacc acagcagtgt tcttaaaata ctggttcagc    31080

atttattagt gagagaggcc acaagttttc tggtagttga ctagcctctc cattgccttg    31140

gagagcccca gagtggtttg ccccacgttg catgctttac ctgtgcaaaa gtcttttcat    31200

tatacctaac cttctcaaag gcagtttagg agccatctgt tgtttctacc ctaccccaag    31260

cggcttatca agtcttcctt ccaaccatac ttcctcaggc gagtcttgat aaatatcctg    31320

gcctttatta agttatgttt ccagtgatat tttatttatt tgtttttatg tttattttta    31380

tttttttgag gtggagtctc atgctgttgc ccaggctgga gtgcaatggt gcgatctcgg    31440

ctcactgaaa ccttcgcctt ttgggttcaa gtgattcttg tgcctcagcc ttccgagtag    31500

ctgggattac aggtgccttc caccatgccc agctaatttt tttttttttt gtatttttag    31560

taaagatggg gtttcaccat gttggccagg ctggtctcga actcctgatc tcaggtgatc    31620

cgcctgcctc agcctcccaa agtgctggga ttataggcgt aagcctccgt gcctggcctg    31680

agtgatattt tagtgctctt tttgggtgga gctgtggtcc cagcctaact tccaggactt    31740

cagccggctc caggacacac tgtatttctg cctccttcag aaggagcaga gatagcgttg    31800

tggatgtaga gatgggtgac aggctggctc cccttgaggc ataagtctag aagaatagtg    31860

gaagaaaccc actctgtttc ccttgacatg aggctacaga gagaatttgc atttaactcc    31920

ttttccttag aagctgagaa ggtagtgtga ggctgggact tggtctagaa gcacatgggg    31980

aggtggtcta ggcttcattt agctgggccc acactgagtg gtgctgcctc taccctgctc    32040

tttgtctttc aaaaaacagt ggccagtgag ccagaaacct aagagattga gttgttgaga    32100

aaaaggctca cagcctttta aatacttacg aatttattac tacaactaag tttttgttta    32160

ctctggtatt tgtctccagg aaagaagcca taagtcttat ctgaccaaag agatgatttt    32220

gaaacaccca tttaatatct tagtgtttat ttgtaccagt tgcactgaag taaataccac    32280

caatttacgt aaatttatct ttccatgttt ctgttatctc tcaggaaaaa acaccctccc    32340

aggccagatt taatgtattt acagcacttt ttaagtttga aaatgaatta aatatatttc    32400

tagtattttt agttatctat tgcagattat agtttgactt ttggcctttg tcccaggaca    32460

aaacctggag agaagagatt caatgaccct gaatattgtt gttttatttt tagagttctt    32520

gatatgaaac tattgtttat ccctctgggt acatgacaaa aaacagtgta agtggcaaat    32580

ttggaaatgt cctctttatt tcccagatta tctaggtcag tgttacctta ttctacctcc    32640

tggatttact ggttcaattt ggctaaaatg gaaaaaccag tattgttcct aagggggtat    32700

gatgaaggct aatgatactg ggattcagga gatttacaga agatagaagc attgactctc    32760

tgcttctatt tcctaaaaac ttaactccca agtcttaaaa agattattac tctagcaaac    32820

ttagaaacat cacactaact catggaaata ctgatctcca tcctcctgcc tctttggaca    32880

gctcctgaag atctgtataa ggacttcctg accttggagc atctcatctg ttacagcttc    32940

caagtggcta agggcatgga gttcttggca tcgcgaaagg taagaaaggt tgaggggaaa    33000

tcagctatct tttcagatca caggtttgga aataagatgt ccagtgtcag ccattggtgc    33060

ttgtttggga ttgtaattca ttcaccactt ctacgtcttt tagaagagct ctactgggga    33120

ggctctgttt ctgctgagta agagtggtta aggagttcat gaaattaagc tgtataataa    33180

aggcttgtca agcatctact aagtgtgagg cagtcttctg agcactgagg atactgtggt    33240

gaacaatcag gcaaagctct tcaccttcat ggagtttaca gttctagtgg gtagagcaaa    33300

caataagcaa tataaacaag taaaacgtgt tgtaggttag atgagagtaa atgctatggg    33360

gaaataaagc aagaaagggt tatagaatac acaggagcaa tgcacttgtg tatgtttatg    33420

cttctctgtg tgtgtacatc tactttaaac aaggtagacg aggaaggctt tactaagaac    33480

ttgacatttg agcaatgacc tggaaagggg aggggctgag ccttacagat atcttggcat    33540

gagaatcatt tttaatttat tttacattca tcaacatcca tcaaaaagta tttgttagga    33600

gtataattag aaacgaggaa ggacaggctt cagatgagag cgattaaaag agctaaaatt    33660

agaaaagtag gccaaacaaa ggctgagatg gggacgtgac aagttacaac tattccaaag    33720

gttgtaaaca ccaagcgggg agcaaggctg gtggcagtga ttcccctgga aaggataaaa    33780

ggtgtaattt tatattaggt aacaatactt caaattaagg atcaggaaga actatcagtt    33840

gacagaatgt attcatgcag cttaatgaag aaagaaagac ttaagtcata tttttttttg    33900

tttttcctaa attagaatga aatcttcaac ccatgttttc cccttctcat agcattaaag    33960

gcctcaggct ctttgatgtt tctgctaggt agctcttatg ttctctctcc caaggggaag    34020

gaggagaact gggaccttat agggttttcc caaagagaaa ggccctttac acttcttgga    34080

gattatgact tattattacc atttttttat ggccggaatt cgccacttag tcagggttcc    34140

ttttggggac taggaagaga atggaaatga atgtgggaat gctttaactt tccttacatc    34200

taccagacta tttcttgaat ccacttggtt gtcgggttaa aaaaggaaac tttttgtttg    34260

gggggaaaag tcaaaaacac tgtctgtttt ttggaattgc cagtgttgct caattgtgct    34320

agataatgtg cttctgaata tgccttgttc agaggagagt gccatacaga tttgaggtgt    34380

gggaaggtca gcaatgcctg gcttacatga tcacttctcc aatgatttaa gaattctcct    34440

tttggccagg tgtgttggct catgcctgta attccagcac tttgggaggc caaggtgtgt    34500

ggatcacctg aggtcaggag tttgagacca gcctggccac catggtgaaa ccccgtctct    34560

actaaaaata taataattag ctgggcgtgg tggcacacct gtggtcccaa ctacttggga    34620

ggcagaggca ggagaatcac ttgaacctgg gaggtgaagg ttgcagtgaa ctgagattgc    34680

accactgcac tccagcctgg gcgagagtga gattccttct caaaaaaaaa aaaaaaaaaa    34740

aaaaaagttt tcttctaagc cattgattca tttcttgtgc tccccaagac tcattttctt    34800

acaaaatatc atgtggagct aaagctgccg agtagtagga agttagctga agtttggagg    34860

atacagagaa aggagaaact gagaagctaa aaggaagaga aagaagtcaa gatgaatctc    34920

attgtactat taatgcacta gaaaatcaac ctgacttgtg ataggctgaa attgccttaa    34980

tagaccttta taataaccca gcactttgaa atcaggggaa gccacattgg gaattgttta    35040

tcagagccag tctggcttca gcttcatacg gaagggggaa accaacaaag agcactaaac    35100

caatgagagc cccttgtttc tgatttccgt gcattcattc aaaaaacaaa tcccgttctc    35160

ggacctcctt agaataacac gttttaaacc aaatatgggg ccaggtaaaa ggaatgtgtg    35220

gatgtgacca gaaacacact cttttgtgtc ctagaggagc ctatttatga ttccatcatc    35280

atattataac ttaattattt aactccaaag gctggggctg tttatggaat aagcagatgt    35340

gtgtctcagc aaagctcaca gacttttttc ctgaagtgtt gataaaagat actaacccag    35400

tccttgttaa tcagttggct ttctgatgtg ggattttttt ttgatgcatg aggtcacaac    35460

agatgtgaaa gagatcagct gtgccgagac ctaatgcaca catgattctc tttgcagtgt    35520

atccacaggg acctggcggc acgaaatatc ctcttatcgg agaagaacgt ggttaaaatc    35580

tgtgactttg gcttggcccg ggatatttat aaagatccag attatgtcag aaaaggagat    35640

gtaagtttca aatatgaacc cagtgcttgg ttaagtaaca gaattaaaac tcctcgtaga    35700

gagcttcagg acctgtgttc aggaacagag gaagtttttt tcttcagata tttgctaatt    35760

tgggttctga atccttgtct tctacccctg taggctcgcc tccctttgaa atggatggcc    35820

ccagaaacaa tttttgacag agtgtacaca atccagagtg acgtctggtc ttttggtgtt    35880

ttgctgtggg aaatattttc cttaggtaag tcatttcttt ttgtccttcc atccagactc    35940

caaagaggaa gacaaaagtt gtcttttcct ctcctgtact tcatgtctat caggcaaaac    36000

ttctcggaag ctttgaaaaa aaaaatagat acataggtga tgaggatgtg caagattcag    36060

gctcagggtt ttctataaga gaaaatcaaa tcaaagaatg tctcctccct gttttattct    36120

aggtgcttct ccatatcctg gggtaaagat tgatgaagaa ttttgtaggc gattgaaaga    36180

aggaactaga atgagggccc ctgattatac tacaccagaa atgtaagact ttaagaagta    36240

ttcctgtgtt ctctttcttt gctcgcaaat tctccttgcc tggaagactt tccattatat    36300

agaccttctt cattgcccag ttagtgtcct gcttttactt tggggccttt cttgataatt    36360

tcaagcatgg agtcatcact tcttgaaaag atagtacttt attattcaaa gcaaccagtt    36420

agtttttatt agatgttgct ttaaatgttt tctatacaca ttgagcctct ggagtatggg    36480

actctgtgtc ttacacagtt ttgtatcctt atttagcatc tcacctcgtc agctctttac    36540

aaatgtgtac tcatttaagt gcttattttc agcattcagg aagaaagagg catttaatga    36600

aatcagtgtt ttgcttctct aggtaccaga ccatgctgga ctgctggcac ggggagccca    36660

gtcagagacc cacgttttca gagttggtgg aacatttggg aaatctcttg caagctaatg    36720

ctcagcaggt ttgtcacctc catccaagaa gcacctacaa agagtactta gatgtcaagg    36780

actttcctac tgcctgaact gtctcatggc taccatgcca tcctctcagc cattgaataa    36840

tctactgtat tcttctacat ctgagtaata atgcttttct aaaagctgta attacccttt    36900

tagacagata ggattctaat ttataacccg ggagcagacc actctgattt ctacctactt    36960

atctttttgt tatattttca aatcctcttc taaagttaaa acaaagaaaa aatctggttg    37020

atccacagaa gatcaacaat ggaagaaatt tcaagaaatt tttaataaat tctgcaggca    37080

aaaatacatc taagctatgc aaaagagatg gtttctgtct tggtatcatc ccaggttctt    37140

ataacttcca ctggaagatt ttagagttgt agtgtttact attagaatgt tatttaatct    37200

ctagtcaatg cctcttacta caatggaagt gaatttcctc tttcttttct tttgaacagc    37260

tgggggacga taggtcagct ctatttttat caataaacct tccaaacatt tacagatatc    37320

aaatagccct ttatttcttt ttcttgatgc aataatatta agttgtgcaa ccttttctca    37380

aaagacccat tttcctaccc atttgttgct tttctttaga ctgtcatcag tttttccatt    37440

gccttgaaat gtggtggcta aaactggatg ccatgccctt tgaagggctt ggctcgtgtg    37500

gttagggctt tgtgaatgag tgattttttg ttctatgtag ctccttgtgt tctgttgtta    37560

cctctctgac cacagcctgc tttctcttca ttgtaactgc acttccctgt gggctgctta    37620

cccatcttgt ttttagttct ctcctttaat ataccttcca tttcaacagc tttttgtttc    37680

tgacacatga tttgtattgt tgtcttaaag ttctatgttc agatatgaaa gccacacacc    37740

ctatgtagcc aagaagtccc tgtgcccttt gtttttaatg aaaaggcact tgaagaactg    37800

aagccataac aacagtcttc tgtgtttatt gtttcaggat ggcaaagact acattgttct    37860

tccgatatca gagactttga gcatggaaga ggattctgga ctctctctgc ctacctcacc    37920

tgtttcctgt atggaggagg aggaagtatg tgaccccaaa ttccattatg acaacacagc    37980

aggaatcagg tactgtatat ggcctaacat cccccggggg agggtgactt caaggccatc    38040

tcgggagggg gattggaagt ggaaggaaga ccttgtctaa ggctgttgca tcccacttcc    38100

acataacctt agccctgagg ttaacataat ggggaatgct cctggaagag ggcctgggta    38160

ggtgtgcttc ctcccatctg tagcccacgc tgctgccaca gcattgcctt taagaattcc    38220

aagccctgca gctgcaatag ctggaatgcc acagtttgct aatttccaga ataaagagac    38280

gagttttaca aagacatctg catttaaatt atccccgtgt atgcttttat taatgtgaat    38340

taaatggctt aggagagatt cagaaaggaa gagttctgtg cttgcatgag aacatgctta    38400

tggctctctg gcaaggatac agaaagccat gggtctgtgt ccggaattag actggacact    38460

gcatctcaga agcccctccc acgtctgatt ttcagcattt tatttgcata atgggatgtc    38520

tgggcttatt taaaacacat gcactgcagt cctttcctga tttgcagagg ggttctaaag    38580

gcagctttct tttttctctc tcccagcacc tgtgcataag gaaagagttg gtgtggtttt    38640

ctacaatatg atattaaaat tgccctttac taaggctggg actacttcat tttgctttgt    38700

ttctttccta acccgtttgg gtgttttcct gctttaatgg aacccctgac agcatgggtc    38760

cagcctgcca gcccgagtgt gcctgggctg cagggagggg cagggagctc tctcatgtcc    38820

agaacttggc caggttgcca catggcaggg gatgctaagg agaaactcgt ggacagtttg    38880

ccctctagag tcgtgtgggg cagcagaaac actgatggga aggaagaaag cttagaagcc    38940

agcaagacag ctgaccgttc cattgaagtc aaaagcatta ggcatatttt taaagaactt    39000

tgccgtatat tatcagatgt tgcccacatc atgacactca gagtcaggca aggtagaaac    39060

aatgatcttt ttttttgatg tattattgaa catgaggctc agttctatta cctgagggca    39120

gtacaaactt gtagttaaag atcaggtatt agagtcagat agaaatgagt aggaccccca    39180

agtctgtctt gtagcagctg tgcaacttgg ggcaaatcat ctaccctctg cctcagtttc    39240

tttatctgtg aaatgagaca aggtcagtgg tgctgtttga aaatggctgt tttgagagtt    39300

ataagatata atctatttct aagcacctgg cccttgaaag cactcagtaa aagataccta    39360

ttaagtgagc tgcttaaaat cacatccttg agatgaatcc agttcctctg acccctaagt    39420

ccatgttgtt tcctcccatg ccaaggaggg ccctcagaga gaaacagtaa tgagatgaga    39480

ctacaattcc actcctgtgt ttacacattt ccagttcaag ttgagctggc cttttagtgt    39540

gacagttgtt cccacacacc attattgcct ccccctttat cagaaagcca tttgatcatg    39600

aactacattc catgtgtttt ctgtgaccaa gtagagtgat gatccgagtc ggcagcctcc    39660

tggctcaccg ggtgctttgc atatggtgct gagcaggaga agaaatcatg tttgtgtaat    39720

ggaagcacca aatacgatgt tggatatata gaagggctgc taacgtttat ccccagaagc    39780

gtggacaaat gtgacaccac actcccagca caggcctggc tcctattttc tgtctgtgat    39840

ttttgaattg gtttttccag cccagtttct cttttatcca gccataattt gaaaaataaa    39900

atggaaattg gaatcttttg tctgcatctc ctctccacct cctccacctt ttttcctttc    39960

tataaaataa aactcacggt cacattttaa tcatctggtt ttgaagaaaa gcagatagag    40020

gcatttgcac acggcatgct tcattctgtt gctctcctgg ggttctgttt ctctggggag    40080

aatgagttga ggctggggta cttctcaggg agcttgttct atcctcttac gcatttctgg    40140

ccaagtacaa aagctgagca gtctttctcc ttctaatttt caattctatt gcattataaa    40200

tagagttgga cagagatatc actgtgggag ctagcttcat gatttgttgc ccctttaaac    40260

catttgaaaa atatttactt agcatttatt tagagaaaag gctgagaagt gtgtggggga    40320

gggaccactc atgtctagac ttagctttgc ctctaatttc ccctgtggac cagctctggc    40380

ctcaagtttg catgcttcct gcaagaaaac acatacttgc tgggctcatc tttctttgag    40440

ggcagtttgg ggaccatcgg caattgctct gtcattttcc ctgggagttt cacctcacac    40500

atcaagcagc ttatcaaaaa tttctttgca gttctctctt agagaaaggt tttggtacat    40560

accattttct tcattttgta attgttaggg atgattaaat ggcccttgta gattgatgct    40620

tggggcagcc tgctagctag gtattcctga gtttggctct accattagac tgtttgcagt    40680

gggactgtcc tttctgcact ttttgtctgt ttcatacccc gtacttacac ccctgaccct    40740

gctactgcat gatcagtgca tgcatgacaa gagaacagtg ctgtgcacat actgggtgct    40800

taataatggc ttgaacaatt gtgtctgctg ttttcttctt tcttttccct cctgatactc    40860

ttccaaggga gtctgtatgg agtagagtaa aacaaaacaa aaacttcaca tgggctttag    40920

tgtctgaagg cctaagtttg agtcccagtt ctacctttta ttagccattt tctccctaat    40980

ccttgactcc ctcatctcca aaggggaaat agttaaaaga cctgtttctc cgtcttagga    41040

gaaacagatg caccattgtc tgtgaaaatg ctttgtcaat catgagagga tcatgccatt    41100

taaaaaatta ctggattaag aatttaagga gctgtccttt ctaaggcagc tgaattattg    41160

tccaaactcg ccaaccctag ttgattctat cccctagata tctctagaat gagcccatgt    41220

ctccaaacct catgggcatt ccctttttct agccaagctg cctttctttc tcctgaagaa    41280

gtgcagtatt tgtctcttgg gtcttatgcc tctagtctta ttcttttcaa tccagagtca    41340

attctctaaa gggcatatct gatcttgtca atcccatgcc taaaatcctt cagtggctct    41400

tcattgccct caaaataata atccaaacat tccagttatg tgattttgga taagttcctc    41460

aaattttcta tgccttggtt tcctcatctg aagagttggg atagtaatac tcacccctag    41520

agaggtaccg tggtgaacac atcatgagat gctgcttaga cagcttctgg cacagtgtca    41580

ggcttgcggc agattatcag tgagggcttc ctgaacaagt gaatgcagga atgattgact    41640

acggtaccag tagtgtttga caactgttac ttttaggggt tggacttaga aagtaggctt    41700

tgcttgcacc ctgtgtatca tatcctctta acttgtggag tttcctgagt gaggatgtca    41760

ccggaaaatc tcattctctc ctctctctat agggaggaac cagcctcttg gggtagggga    41820

gagagaatta atttccattc ttctcctttg gcccaaggtc tatgcagcat gttccagaag    41880

tctgcttgta gtgggaagta ggctggtata ggaatgaaga atgtattttc tgtctcggtg    41940

ggcccttcca gtgaatagga cttcccttcc ctccacttgg gctgtaagtg attttgatag    42000

catcaactag actcacccaa agccacacgg ccgggaagga gcattctcaa gaaggagagg    42060

atctgttgtt caacaagtct tattctttgg actcctgaag gaagctttgg aagtcaaagg    42120

agaaaaatga gctttgtttg aagagggcat tattcttcct aagagcaata agcccaacat    42180

tctctatgtc attcatcttc ccaacatccc tgtgagctgg ggagggagtg ctactgccaa    42240

cacatcttat agatgggaca agagggtcac agaaatattc atgactttct caagtttctg    42300

cagtcagtgg tagactctga aataggcaaa atatcttgtt attctcaaac cactgctctt    42360

tcctgagaca gcaactctgg gggcgaaaac gaggggacag tgagactcag cccaccttct    42420

ctttgcacac caagcctctg ttacatggag gaggaagagg ttgtcttcaa atcactgctg    42480

ggttcagtat cctttaagga gaccttcaga tgtttcctct gcctatcttt cattgaatgg    42540

ttgctctgtg agcattatcc agaaaaactt tcccaggaga tggccagaca gatgtgaaac    42600

actcagtaat atatccagag ctcgatggag gaatcccatg caatcaggaa gccaagtaga    42660

aggcagttga tcactccatc tgctgttgtt gtctttagtc cagaactgga cctcagaagt    42720

aggattcaaa agaacaggct catcgagact cctcagttat attatacttt taaatgtact    42780

ttctcaggaa attaagcctt ccatgtgtgc tagcagagaa agatttttat tttgttttgt    42840

ttttctaaag gatgttttga aggttgctat taagtttgtg gttgaaagat aatgaactta    42900

ggtagccgat ctgcagtcaa atataccacc actaaaatat aaatatttgt tcttttgcag    42960

tcagtatctg cagaacagta agcgaaagag ccggcctgtg agtgtaaaaa catttgaaga    43020

tatcccgtta gaagaaccag aagtaaaagt aatcccagat gtaagtacgt cttttaaaaa    43080

tagtcttaga aataatacaa aggatgaaac actagctaga taaatattag cctaagcatt    43140

aaagttttgg agcctcatta gaaggctgcc ctcgagtgtg tgtatcatgg ggtcattatg    43200

gagatggaac tttgtttttt tcataagtaa agcccttggt ccaaggttca agacagtgta    43260

gctttctgac caatttcact aaagtgcaag tagtgtcata gtgaagacag cgatggtaac    43320

aggcattctc agctgctgat ttgtaaattt tctcttctcc ctggcctgtg tctactcata    43380

ggaagcagtt gcttcctttt gtagcttgga caatttgtgg ctatgatacc tttatgttct    43440

tccacaggac cttatttgat agacatgata gatgggttga gaaatcagct taattaaata    43500

gttggtcatt ttatatgctc aattaactgt gccatctcat tgtctcttaa aaaggacaac    43560

cagacggaca gtggtatggt tcttgcctca gaagagctga aaactttgga agacagaacc    43620

aaattatctc catcttttgg gtaagactca gccatattaa aaagacaaat ttcaatagga    43680

atttttggaa ggaacttagg actttcagtg taagtgcaga attttcccta tggggtcttt    43740

gttggttgga gaaattagca tcaatttaac aaataaagaa tggaaactaa ccacacaata    43800

aaattaagtg ataaatctaa aaataatctg aaataaatta gagaatttgg tcaattttta    43860

tgagaattca tgaatactag ggaatttctg tgtatattta ctgtggtcag taatggctaa    43920

atgaaaaagg tgattggatg tgatccgtaa agctgtcaat atgattacaa tctttgtgga    43980

ctctgaagaa tttttaagtc tgtatacaaa tgggtgcatc tgtgcttaag aagtatgata    44040

tataaataag ccaatatcta tttgtttgag acatttaaat attattgtct gaattcgaag    44100

tatttcattg tgagaaaagt attaaaatta gttttaaata taatctccct tctatggctc    44160

agtaggaatt tgtaggtgtc ttgaatacgt gtacgttctc ttaacataac aaatcaatga    44220

aaatctatat ttataagaat aatagaataa gtgtagttat gtatttgctg gagtttattt    44280

gctagagtat tcttacctaa aggtaagaat agaggaggtt ttgatctgct tataatcttt    44340

tatataaaat gggaatactc atgggttttt gaataatgct cataccaaaa agaaaacaaa    44400

caaaaaaaac cccaacatat taaaaggtgc cattgtgcta ttttattgtt ttctttaagg    44460

cccaaggtaa gaaattgtga aagtcaatga tatgtttcat tcattgattc aaaaaatgtt    44520

tattcggcaa gtatcatgtg cagagcacca tgccattgct tgagacacct acattagttt    44580

tgttggggtt gaattgaaag aaaaaattgt atttctcatt atttgaagta acttttaaac    44640

tatgtataaa cacgagttac taaaattccc ttttgcagtt ttaacatgaa gaagttgggg    44700

aaaacaccta ttaccgggaa aaaacacctt agaatggctt gtgaaagtgt aaatcctgaa    44760

gttttagatc aacacagcct gcatttctag gctttgacat gattaccgtc tgtcaggatt    44820

ccatgccatt gaaaacattt tctagttgct gctgagtgac aggggttctc agtccttcca    44880

aggaatgtgg ttttgatgag taaaaagcag cgtttgatat gtctggcttg actgcacaca    44940

tgcttcaagt tattaaagtt taaagttgct caagagcttt attacaacca tacacatgcc    45000

ccgtaattcc caaattgcca caataggaaa agcacaagtg aaatttaaga acatcccaat    45060

ttccttgaat atcatgcaag tggccctttg gcgcctgtca ctgtatacaa atttgtcaat    45120

ctgcgaggcc ataaacatgt tccatcagtt ggggcctttg cataactcga gagaactgcc    45180

tttcatctca tttgaggctt gaaagacttg gacctgagta agaggactta tctgcaacta    45240

ctaattcatg cgagtacctg aaaatagacc ttgtccctgt aaacctgcta tgctgattaa    45300

caactgggag agatacgggg ctgcggtctc cagggagatg gcagccatat ggagttggga    45360

atggggtgag ggtaaaaagc aaaagaattg tcttctctct gccaactcct ttgtttgcca    45420

tttcttctgc agtggaatgg tgcccagcaa aagcagggag tctgtggcat ctgaaggctc    45480

aaaccagaca agcggctacc agtccggata tcactccgat gacacagaca ccaccgtgta    45540

ctccagtgag gaagcagaac ttttaaagct gatagagatt ggagtgcaaa ccggtagcac    45600

agcccagatt ctccagcctg actcggggac cacactgagc tctcctcctg tttaaaagga    45660

agcatccaca cccccaactc ctggacatca catgagaggt gctgctcaga ttttcaagtg    45720

ttgttctttc caccagcagg aagtagccgc atttgatttt catttcgaca acagaaaaag    45780

gacctcggac tgcagggagc cagtcttcta ggcatatcct ggaagaggct tgtgacccaa    45840

gaatgtgtct gtgtcttctc ccagtgttga cctgatcctc tttttcattc atttaaaaag    45900

catttatcat gccccctgct gcgggtctca ccatgggttt agaacaaaga cgttcaagaa    45960

atggccccat cctcaaagaa gtagcagtac ctggggagct gacacttctg taaaactaga    46020

agataaacca ggcaatgtaa gtgttcgagg tgttgaagat gggaaggatt tgcagggctg    46080

agtctatcca agaggctttg tttaggacgt gggtcccaag ccaagcctta agtgtggaat    46140

tcggattgat agaaaggaag actaacgtta ccttgctttg gagagtactg gagcctgcaa    46200

atgcattgtg tttgctctgg tggaggtggg catggggtct gttctgaaat gtaaagggtt    46260

cagacggggt ttctggtttt agaaggttgc gtgttcttcg agttgggcta aagtagagtt    46320

cgttgtgctg tttctgactc ctaatgagag ttccttccag accgttacgt gtctcctggc    46380

caagccccag gaaggaaatg atgcagctct ggctccttgt ctcccaggct gatcctttat    46440

tcagaatacc acaaagaaag gacattcagc tcaaggctcc ctgccgtgtt gaagagttct    46500

gactgcacaa accagcttct ggtttcttct ggaatgaata ccctcatatc tgtcctgatg    46560

tgatatgtct gagactgaat gcgggaggtt caatgtgaag ctgtgtgtgg tgtcaaagtt    46620

tcaggaagga ttttaccctt ttgttcttcc ccctgtcccc aacccactct caccccgcaa    46680

cccatcagta ttttagttat ttggcctcta ctccagtaaa cctgattggg tttgttcact    46740

ctctgaatga ttattagcca gacttcaaaa ttattttata gcccaaatta taacatctat    46800

tgtattattt agacttttaa catatagagc tatttctact gatttttgcc cttgttctgt    46860

cctttttttc aaaaaagaaa atgtgttttt tgtttggtac catagtgtga aatgctggga    46920

acaatgacta taagacatgc tatggcacat atatttatag tctgtttatg tagaaacaaa    46980

tgtaatatat taaagcctta tatataatga actttgtact attcacattt tgtatcagta    47040

ttatgtagca taacaaaggt cataatgctt tcagcaattg atgtcatttt attaaagaac    47100

attgaaaaac ttgaaggaat ccctttgcaa ggttgcatta ctgtacccat catttctaaa    47160

atggaagagg gggtggctgg gcacagtggc cgacacctaa aaacccagca ctttgggggg    47220

ccaaggtggg aggatcgctt gagcccagga gttcaagacc agtctggcca acatggtcag    47280

attccatctc aaagaaaaaa ggtaaaaata aaataaaatg gagaagaagg aatcaga       47337


<210>  13
<211>  1033
<212>  DNA
<213>  Homo sapiens

<400>  13
agactgaccc cattctctgt ctgtgcctgg gttgctgggg actattatgg gatgcatttc       60

ctgaggctct gggcctcaag ttggccctga atcagctgag tcaagatcaa gtctaggttg      120

aaaactgagt gagggccagg tgcggtggct caggcctgta atcccagcac tttgggaggc      180

caaggcaggc agatcacctg aggtcaggag ttcaagacca gcctagacaa catggtgaaa      240

ccccatctct attaaaaata caaaattagc tgggtgtggt gacgcgatcc tgtaatgtca      300

gctactctgg aggctgaggc aggagaattg cttgaatctg ggaggcagag gttgcagtga      360

accaaaaatt gtgccacagc actccagcct gggcgacaag agtgagactc catctcaaaa      420

aaaaaaagaa aaagaaaaag aaaagaaaac tgagtgggat gtgaaggttt atgcagaatt      480

gcaccaggca tttagcagga gaagctcaaa ttgccctcca ggcttcctta gaaaagccca      540

agtcactgtc cccttttgct atggtaactg caagtcctgg acaggtcctg gcctttggat      600

gcttgtctcc caggcatgac tccaacaatg catcccatgg gatttggggt tccccagatc      660

tggggcttgt aggcctgact ctcccctgtg cacacgtctc atacacgcat gcgtgcaccc      720

attgcctgcc ccgccccttg cacagggagt cagcagggag gactgggtta tgccctgctt      780

atcagcagct tcccagcttc ctctgcctgg attcttagag gcctggggtc ctagaacgag      840

ctggtgcacg tggcttccca aagatctctc agataatgag aggaaatgca gtcatcagtt      900

tgcagaaggc tagggattct gggccatagc tcagacctgc gcccaccatc tccctccagg      960

cagcccttgg ctggtccctg cgagcccgtg gagactgcca gagatgtcct ctttcggtta     1020

caggaccctg act                                                        1033


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guide sequence

<400>  14
ttcccggtag aagcacttgt                                                   20


<210>  15
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  15

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  16
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  16

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


