                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, A Body Corporate
 
<120>  BIOMARKERS FOR THE DIAGNOSIS AND TREATMENT OF FIBROTIC LUNG 
       DISEASE

<130>  UNCO-018_001WO

<150>  62/525,087
<151>  2017-06-26

<150>  62/525,088
<151>  2017-06-26

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  1
agaaagaagt catgaaagta ggaaccacat ttttactcat ctttctgtct ccagcaagca       60

gcttactgct tttcatacac attttgcttt tattactcat gatttcaaag gtgtaatggt      120

tcagccacat caatgtaaca aacagttcac actgggctct tatagtctgg cctttaaaac      180

cttcactatt tatgctttca tcttaactac tttgaccctc acaggtttac tcactaagaa      240

cttgagtttc aagagaaaag atgacatgtt tgctgcttaa acaagcaata tctaaaagca      300

tatttagtta taaacgtctt accaagaatt gatataattt tcatttaaac atttttataa      360

atagtagttt acaagatata gtaagtacat ctctaaaaat acagtgtatt catgtacctt      420

gacataaact tgtagtagta ccttagtttt attcatgttg ttatattaac taccatcact      480

ttgaatacat acctgttcac bgtacagtat aggtcggttt aggtttattg ccttaattgc      540

ttggttttga gttagtactg tagcaaatgc tatcacactt tgcattccct aaaaacaggt      600

aaattcatta aggaaacaga caaagtatat aataatctcg ctacataaat atttcaagat      660

cagctatctg cattctgata aaattgtttt taaaatttaa gcattccttg gactttgaat      720

tgtaagttga tcaaattcaa aaatgaattg ttactgtatt cttctctcct ggccctaaaa      780

tctatctaaa acatggcatg gggagtttct taatgtttca gtgtccattt cctgggtgtt      840

tccctctagg ttttttttcc tcacccctca agcttctatg tggatcccag ctagagctca      900

tactacttat ccaacacaca tcattgtgca agcactcttt tatattcata ctagtacttt      960

taagtgtgtg tgcggtggga aaaggttacc aatcacattt t                         1001


<210>  2
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  2
gtattcatca actcctattt cattccctct tcctgtgctc actggaagat gacatttccc       60

agacttccaa gaatgttact gagttctgga atgtaagtag aagggataag tatcacttct      120

gtgctgtggc ggttatggac ctgtgaactt tgcacacgcc ttctatcttc tttttcagtg      180

tccatttcag agggcatgtt ttcagatgaa accagtagaa gatggaagca gcctgtgact      240

agaatcactg cttagggtct tgctgcctag gaatcccact ctacctgcaa cagactgtga      300

aagaaccgag aaatacactg attttgaaca tagcccatac tataatgggg atgtttgtta      360

cagcagttag cattaaaaac cttggctagg cattggtcat aattgtagaa cacagcaaat      420

gaagggaaac tggaacatag aggccagtga gaactttagg gttaatgaaa aatgagggca      480

accaggataa tttggttctt kgccaaatag gaaggtgaaa ccaaaggtag actggaggtc      540

agaaaatcag tccagcacat gtgatgtttt catttagttg cctgtatgtc tgtctggtct      600

ccagctcagc ctggctcctt gaggtaagag gcagtggctg ttcacctttg catcccagca      660

cctggcatac aatagatggg atgaaatgtt caaactgagc ctaagcttca gggtgcttat      720

caaagcaggg aagatacaca agaggagatg attcaggtcc agggcaggtc aggtatctaa      780

acccagtctc ttaggaagct ggatcctccg aaccagggag aacaagctgg atatgcactg      840

gatttcccag cagtactgat ctagagactc tcatagagtc ccttttattc cttggcctag      900

ggttacaact gcttatagca tctggaaaga ctcaacacct caaaagagac tttcagtaga      960

tacagcaaat acactcatgg aattgataat taagcttcaa t                         1001


<210>  3
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  3
attgtcgttg tttgcttttg tttattgaga cagtctcact ctgtcaccca ggctggagtg       60

taatggcaca atctcggctc actgcaacct ctgcctcctc ggttcaagca gttctcattc      120

ctcaacctca tgagtagctg ggattacagg cgcccaccac cacgcctggc taatttttgt      180

atttttagta gagataggct ttcaccatgt tggccaggct ggtctcaaac tcctgacctc      240

aagtgatctg cccgccttgg cctcccacag tgctgggatt acaggtgcaa gccaccgtgc      300

ccggcatacc ttgatctttt aaaatgaagt ctgaaacatt gctacccttg tcctgagcaa      360

taagaccctt agtgtatttt agctctggcc accccccagc ctgtgtgctg ttttccctgc      420

tgacttagtt ctatctcagg catcttgaca cccccacaag ctaagcatta ttaatattgt      480

tttccgtgtt gagtgtttct ktagctttgc ccccgccctg cttttcctcc tttgttcccc      540

gtctgtcttc tgtctcaggc ccgccgtctg gggtcccctt ccttgtcctt tgcgtggttc      600

ttctgtcttg ttattgctgg taaaccccag ctttacctgt gctggcctcc atggcatcta      660

gcgacgtccg gggacctctg cttatgatgc acagatgaag atgtggagac tcacgaggag      720

ggcggtcatc ttggcccgtg agtgtctgga gcaccacgtg gccagcgttc cttagccagt      780

gagtgacagc aacgtccgct cggcctgggt tcagcctgga aaaccccagg catgtcgggg      840

tctggtggct ccgcggtgtc gagtttgaaa tcgcgcaaac ctgcggtgtg gcgccagctc      900

tgacggtgct gcctggcggg ggagtgtctg cttcctccct tctgcttggg aaccaggaca      960

aaggatgagg ctccgagccg ttgtcgccca acaggagcat g                         1001


<210>  4
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  4
atttgggaac ctttaaaaaa tattctggct tcaaaaatac tccatattta catctttggt       60

tctatctgaa gtaaagccgt gatggtgtgc gtaagtgaaa caggtgcaaa ggggcaacaa      120

caaagggcgc ctctctttgt ctttgtgtcg caggcggaga tggacatggt ggcctggggt      180

gtggacctgg cctcagtgga gcagcacatt aacagccacc ggggcatcca caactccatc      240

ggcgactatc gctggcagct ggacaaaatc aaagccgacc tggtacttgt ctgtgtttca      300

ttttagagtc ttcaaaatat ctaccgaagg atcgtgtaat tactcaatcc cagggagttt      360

cttctgaaac attgctatta tttctttccc agaagactgg aaatgtttag aaatcccact      420

tcttaaatgg ggaagtggaa tcagtagccc tattagagat tatgttaaca cttgaagagg      480

agttaaacca gaggctgagg ktgtgcaaac actcatttgc agtttgtgaa taagtctctt      540

taggggtggc agtttgtttc tgcggtaagc agaacatctt tttgaatagg ggaaatgcaa      600

cagtcttata cagtagtttg tgtcattggt gaatcctttc ctaggtggta attaaaacat      660

tatttctact gagcaaagcc atatgtcatc ccgacacccg ctcccatgct gaaaaaagtc      720

agacttgaaa ctgggttgag aattacagca taaaatcata actgatctta agtgcttagt      780

ttcccgcagg tctctacact tgtaaatcac taaacttttt tttttttttt ttacctgaga      840

ccatagcttc tcatcctcat ttcttcttct ggctttttgg ggcttacttt tgtccacctg      900

agcccctgac caactttctc cttcatttct ctaagaccta gggaatccta aatgatgtct      960

ttaaacttta agacaatttt ctaacacgtg agtctttaag t                         1001


<210>  5
<211>  941
<212>  DNA
<213>  Homo sapiens

<400>  5
ttctctgtga gtctttagga aatgaggagc atgatcttct agcagtaaaa cacctgtaga       60

gaattgcctt atgttttttg tttgtttatt tgtttgtgtg ctttggtttg gtttgctttt      120

tttttttttt tttttttttt tttgagatgg agtctcgccc tgttgcccag gctggagtgt      180

agtggcgaaa tctcggctca ctgcaacctc cacctccctg gttcaagcaa ttcccctgtc      240

tcagcctccc gagtagctga gattacaggt gcacaccacc acgcccggct aatttttttg      300

tatttttagt agagatgggg tttcaccatg ttggccagac tggtctcgaa cttctgacct      360

caggcaatcc gcctgcctca gcctcccaaa gcgctgggat tacaggcatg agccactgcg      420

ccccgcctcc atgttaatca mtctttctga tttcaaataa ctcattatcc ccatgacctt      480

atggatttgt ttttcctctt catccacaaa attctccaga gaagtctccc ttgttatctc      540

ttggctgtgc tttctatctc accagttatc tttctccaaa gagcttcctc tgcaaagaag      600

ctttgtatat gaagaccatg tgggggctga atcaagacca agtttcacaa cctaaaagta      660

gttcacaaag cttccttgcc tctattctct gcaaatctgt aaactcttca gctgacccaa      720

tttctctctt tagccttcag agattatttt attttatttt atttcatttc atttcatttc      780

attttgacag aatctagctc tgtcgcccag gctggagtgc agtggcacca tctttgctca      840

ctgcaacctc cccctcacag gttcaagcaa ctgtcctgcc tcagcctccc gagtagctgg      900

gattacaggc gtgagccacc acgcccagct gatttttttt t                          941


<210>  6
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  6
cctctactgc cgtacacccc accactcagc cttggagtgc ctgtgtgcag agcagggctg       60

aggcatggtg ctgctttggt ggtctaggtt tgctgcaggg ccaggtggcc tgagctccag      120

gcaggatctc tggctgcact cagccctttc tgcctcccca aatgctctat atcactattt      180

gtacactgag cagagtaaag ttagagagaa ctgttttata gaatagggct ggcccccgct      240

cccctggcct acgtgatggt ccttcctggc tgccaggtac ttgtttgtat tagagacaga      300

cactccacag ggtctgttgt ggcccacagc acataggcaa tcagaggcag aaagcagagc      360

tgtttggacc cacagagggc cggctgtctg ccactgaaat gtctttccag ttggttgaga      420

agcagcagga tgctctgctg gtgatgtctg aaagtcccag gattctttgg gtctccaagg      480

agatcctagc atataccact rtcgtggttt taataaagag caaaaacact ttcagatggg      540

gagaagagtg gaacaaaagg tattcttcct gggttgaagt ctgggggaaa ggcattgaga      600

agactgggct aatggcacaa accaatgaag tactcaagtc acctgtgatg gaggccagtc      660

atccaatggt atcaactttg tatgtggcaa cacttaataa aaatctgaac aggtcttcac      720

ttgtggacac agtagacttt cttgaaaaag gacagaaaag tgagccctgt gaattttcat      780

ctcacggact gacaacaatg acttgccttt aaggacagtc actcaagatg aagatgcaac      840

aaaacccttc cagttccaag tggctgatga aaaaaaaaaa atcttaaaag catcacagaa      900

caacggagaa agagatcaga agactataac agatagtttg aattttaaaa ctcagagaaa      960

agcaactgag gaggaaatac actgcttaga aagaagaaac t                         1001


<210>  7
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  7
tggacggcct ctgaaggggt ctgtggggtc ctggacgggt ccccattcat ggcaggatta       60

acccccctcg ggttctgtgt ggtccaggcc gcccctttgt ctccactgcc ccctggccag      120

aatgagggac agtgacccac ccagggctgg gcctggctca gactccgtca gagccgcagg      180

gcaagttcct ggcacgtccg aggtgggagg ctcctctgcg ctccaggagg ctgtgcctgg      240

ccccccttcc cggcaggaac cggctgtgtc cctttccttc ctttatcttc tgttttcagc      300

dccttcaact gtgaagaggt gaactcttca aacacgctga gcaaacaggc ccgactccca      360

gggccgcatc cgggatgtct caatagctgt ggccttgacg tccacctcgg acccctgccc      420

cggacccagc ccagttccca atgggccctc tgcccgggga ggtgcctagt gggagggacg      480

agggcaaagt cggggccccc acttgtttgg tgtcactgtg tgccagcggc cactggcggg      540

cgaggctgtt ccagggtgga ggcggggagg gttggaccac aggcactgag cggggacaga      600

g                                                                      601


<210>  8
<211>  732
<212>  DNA
<213>  Homo sapiens

<400>  8
gtcattggtc aaatgtggcc tgtatctaaa ttccaactgt tagaatcata gacatctaga       60

gcttacgtca gttttagata tttcttatga attctcagaa ttcatagatt ctcattttta      120

ttcttagact tctcagatat tccgtttttg atagtatacc cttctgagtc taatatgtcc      180

taaagtgcga acttgtacaa tttttttttt tttttttttt tttttttttt tktgataagg      240

agttttactc tgtcacccag gctggagtgc agtgacccga tctcggctca ctgcaacctc      300

tgcctcccgg gttcaagtga ttgtgatgtc tcagtctccc aagtagctgg gattacaggc      360

tcctgccacc acatgcctag ctaattgtta tactttagta gaaatggggc ttcgccgtgt      420

tagtcaggct ggtcttgtac tcctgacctc agttgatctg cctaccttgg cccccaaggt      480

gctgggatta caggcatgag ccaccgcgcc tgacccagct tcttaaatta ttctgggcca      540

ccagtaatgt gaatcatgta aattaaaata tataattaaa caaaatcata tagcgattag      600

agataatagt tgtgaaatgc ttgaaaaatc ataggcattt aataaataga agccattcca      660

attaggattc ttcttgattt tttttcaaga ccaaaaaaat actcttttaa atatttatta      720

taatactcca tg                                                          732


<210>  9
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  9
aggctgcagt tagtcatgac tgcgcgctgc actccagcct gggtgacaaa gtgaggccct       60

gtctcaaaaa caataaaaaa tttaaaagag ctgagcatgg aggccacttt gggaggctga      120

ggcaggcaga tctcttaagc ccaggagtct gagaccagcc tgggcgacat gatgaagccc      180

catctctaca aaaaatacaa aaaaattagc tgagctttat ggcaaatccc tgtaatccca      240

gttacctagg aggcccaggc aggaagatgg cttgagccca aaaggttgag gctgtagtga      300

gctgtgatca tgaacagagt gagaccctgt ttcaaaacaa aatgaaaaac aaacaaacaa      360

aaaaaccaag aaaacaagaa aacaaaaact atacaatgat gagccaaaaa gcaagatatg      420

gaagaatata tatatatata tatatatata tatagtatga gtccagctat agaaagtttg      480

aaatcaggca acctaaacaa tattgttcag ggatctatac agaggcagga agccattgag      540

aaaggtaagg ggaggattat caccaaattc aggatggtgg ctcccctggg gagaatatgt      600

caaggagggg cacatgggct tggaatactg tcttcattga cctgcgtgtt gggtacacag      660

gagtttgtta tttttcacac tgcatatgtg catgtatata ctctcccata tataccatgc      720

atttcacaca agaacacaaa ggctgtgtgg ctctgctctg cccctttccc cttccagctc      780

ccattctcgt cytcagctag cagaggaggg tcagggtctt ttagcacagc ttccttctgt      840

ctctgagtgg gtcagaggag tacggggatg agggcctccc ttctgcggct gggctctggc      900

cactccaggg tgggaaggcc tggagaaaac agggccaggc aaagccggct ggccctgctg      960

tttctgccaa tgctgggatt aggccagggc tctggcccac ctgtcatttc actcattcag     1020

catgaacata gccactgagc acttactgtg agccccgggt gctattggga gagttcagat     1080

aagtgagaga gggtctttga cctcaaagat cttacagaga ggaccgtata cacaaataac     1140

agtataccag caaaatgtga gctaagtgtc atgtgactac tcatctactc tttcaataaa     1200

tatttgttgt gcacctatta catgccagga actgtgctgg atggtgatca tgtaaagaca     1260

gtcaaatcac agtcctagct ctcagattca cagcctgcct aatgctgggg aaactggaat     1320


<210>  10
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  10
ccagccagaa ggggcgcagt ttgttagttc agctcctcct gagacagaaa taaagacacg       60

aaccaaagga catcagcact tacagggctc tcaggtcaca cacaggatgt ccgcgcccac      120

tgcagagctg caggtcccct ccagggcagt ggggagccac aagcagcgtt aggcagcggc      180

tgggaccagg accgcctgag cactcaagaa cccccactgc cccaagcact gctggcagca      240

agcccagaaa actgagcccg gggagctcct ctgagcggcc taagcacccc tctaagctgt      300

gctgccccaa ttcaagcctg gctcacggca gcaaagaaaa aatgtgacct tcggagctcc      360

caaaggggcc acccataagc tgagagcctg cccggaagca cttatagacc cgcgtggctt      420

gttttcattg caaagaacaa taaaaattat cttgcctctg atcaccactg atagcccaag      480

aagcaaaaat tcgatcccgg dgatgagaaa tgaaatgaaa catcgcgaga aacttccagg      540

aatcttctgg atgtggctag actctttagc ttgagcttcc agacaggccg aggcttggtg      600

ctggagcctg gccctccgct gacctctctt ctacccgggg gcacagcccg gattgcagag      660

aggctggcgc aagagtgagg gagcgagggc tagcctgtga tgggctttct ccacctagca      720

ccaccctatg ctgtggctca ggggagtcaa gagtttacac agctgcagag atggattcca      780

ggccacttac tcaagtctac ctactccttc cttcggccaa tcagctgggt gcctctgcgg      840

cctgtgacac caccagcaaa cagctccaga cctcctagca tggtctctgt caaggctggg      900

tggcagatct gtgatctcct ttttaaattt ttcatttttt ttaagagatg gggtcttgct      960

atattgccca ggctggtctc aaactcctgg gctccagcga t                         1001


<210>  11
<211>  17916
<212>  DNA
<213>  Homo sapiens

<400>  11
cacccggccc ggctccctcc ctgcccgtcc ccgtcccccc acccgtgcca gcccccagga       60

tgggtgcccc gagcgcgtgc cggacgctgg tgttggctct ggcggccatg ctcgtggtgc      120

cgcaggcaga gacccagggc cctgtggagc cgagctggga gaatgcaggg cacaccatgg      180

atggcggtgc cccgacgtcc tcgcccaccc ggcgcgtgag ctttgttcca cccgtcactg      240

tcttccccag cctgagcccc ctgaacccgg cgcacaatgg gcgggtgtgc agcacctggg      300

gtgacttcca ctacaagacc ttcgacggcg acgtcttccg cttccctggc ctttgcaact      360

acgtgttctc tgagcactgc cgcgccgcct acgaggactt caacgtccag ctacgccgag      420

gcctagtggg ctccaggcct gtggtcaccc gtgttgtcat caaggcccag gggctggtgc      480

tggaggcgtc caacggctcc gtcctcatca atgggcagcg ggaggagctg ccttacagcc      540

gcactggcct cctggtggag cagagcgggg actacatcaa ggtcagcatc cggctggtgc      600

tgacattcct gtggaacgga gaggacagtg ccctgctgga gctggatccc aaatacgcca      660

accagacctg tggcctgtgt ggggacttca acggcctccc ggccttcaac gagttctatg      720

cccacaacgc caggctgacc ccgctccagt ttgggaacct gcagaagttg gatgggccca      780

cggagcagtg cccggacccg ctgcccttgc cggccggcaa ctgcacggac gaggagggca      840

tctgccaccg caccctgctg gggccggcct ttgcggagtg ccacgcactg gtggacagca      900

ctgcgtacct ggccgcctgc gcccaggacc tgtgccgctg ccccacctgc ccgtgtgcca      960

cctttgtgga atactcacgc cagtgcgccc acgcgggggg ccagccgcgg aactggaggt     1020

gccctgagct ctgcccccgg acctgccccc tcaacatgca gcaccaggag tgtggctcac     1080

cctgcacgga cacctgctcc aacccccagc gcgcgcagct ctgcgaggac cactgtgtgg     1140

acggctgctt ctgcccccca ggcacggtgc tggatgacat cacgcactct ggctgcctgc     1200

ccctcgggca gtgcccctgc acccacggcg gccgcaccta cagcccgggc acctccttca     1260

acaccacctg cagctcctgc acctgctccg gggggctatg gcagtgccag gacctgccgt     1320

gccctggcac ctgctctgtg cagggcgggg cccacatctc cacctatgat gagaaactct     1380

acgacctgca tggtgactgc agctacgttc tgtccaagaa atgtgccgac agcagcttca     1440

ccgtgctggc tgagctgcgg aagtgcggcc tgacggacaa cgagaactgc ctgaaagcgg     1500

tgacgctcag cctggacggc ggggacacgg ccatccgggt ccaagcggac ggcggcgtgt     1560

tcctcaactc catctacacg cagctgcccc tgtcggcagc caacatcacc ctgttcacac     1620

cctcgagctt cttcatcgtg gtgcagacag gcctggggct gcagctgctg gtgcagctgg     1680

tgccactcat gcaggtgttt gtcaggctgg accccgccca ccagggccag atgtgcggcc     1740

tgtgtgggaa cttcaaccag aaccaggctg acgacttcac ggccctcagc ggggtggtgg     1800

aggccacggg cgcagccttc gccaacacct ggaaggccca ggctgcctgt gccaatgcca     1860

ggaacagctt tgaggacccc tgctccctca gtgtggagaa tgagaactac gcccggcact     1920

ggtgctcgcg cctgaccgat cccaacagtg ccttctcgcg ctgccactcc atcatcaacc     1980

ccaagccctt ccactcgaac tgcatgtttg acacctgcaa ctgtgagcgg agcgaggact     2040

gcctgtgcgc cgcgctgtcc tcctatgtgc acgcctgtgc cgccaagggc gtacagctca     2100

gcgactggag ggacggcgtc tgcaccaagt acatgcagaa ctgccccaag tcccagcgct     2160

acgcctacgt ggtggatgcc tgccagccca cttgccgcgg cctgagtgag gccgacgtca     2220

cctgcagcgt ttccttcgtg cctgtggacg gctgcacctg ccccgcgggc accttcctca     2280

atgacgcggg cgcctgtgtg cccgcccagg agtgcccctg ctacgctcac ggcaccgtgc     2340

tggctcctgg agaggtggtg cacgacgagg gcgccgtgtg ttcatgtacg ggtgggaagc     2400

taagctgcct gggagcctct ctgcagaaaa gcacagggtg tgcagccccc atggtgtacc     2460

tggactgcag caacagctcg gcgggcaccc ctggggccga gtgcctccgg agctgccaca     2520

cgctggacgt gggctgtttc agcacacact gcgtgtccgg ctgtgtctgt cccccggggc     2580

tggtgtcgga tgggagtggg ggctgcattg ccgaggagga ctgcccctgt gtgcacaacg     2640

aggccaccta caagcctgga gagaccatca gggtcgactg caacacctgc acctgcagga     2700

accggaggtg ggagtgcagc caccggctct gcctgggcac ctgcgtggcc tacggggatg     2760

gccacttcat cacctttgat ggcgatcgct acagctttga aggcagctgc gagtacatct     2820

tggcccagga ctactgtggg gacaacacca cccacgggac cttccgcatc gtcaccgaga     2880

acatcccctg tgggaccacc ggcaccacct gctccaaggc catcaagctc ttcgtggaga     2940

gctacgagct gatcctccaa gaggggacct ttaaggcggt ggcgagaggg ccgggtgggg     3000

acccacccta caagatacgc tacatgggga tcttcctggt catcgagacc cacgggatgg     3060

ccgtgtcctg ggaccggaag accagcgtgt tcatccgact gcaccaggac tacaagggca     3120

gggtctgcgg cctgtgcggg aacttcgacg acaatgccat caatgacttt gccacgcgta     3180

gccggtccgt ggtgggggac gcactggagt ttgggaacag ctggaagctc tccccctcct     3240

gcccggacgc cctggcaccc aaggacccct gcacggccaa ccccttccgc aagtcctggg     3300

cccagaagca gtgcagcatc ctccacggcc ccaccttcgc cgcctgccgc tcccaggttg     3360

actccaccaa gtactacgag gcctgcgtga acgacgcgtg tgcctgcgac tcgggtggcg     3420

actgcgagtg tttctgcacg gctgtggctg cctacgccca ggcctgccac gacgcgggcc     3480

tgtgtgtgtc ctggcggact ccggacacct gccccttgtt ctgtgacttc tacaacccac     3540

atgggggctg tgagtggcac taccagccct gcggggcacc ctgcctaaaa acctgccgga     3600

accccagtgg gcactgcctg gtggacctgc ctggcctgga aggctgctac ccgaagtgcc     3660

cacccagcca gcccttcttc aatgaggacc agatgaagtg cgtggcccag tgtggctgct     3720

acgacaagga cggaaactac tatgacgtcg gtgcaagggt ccccacagcg gagaactgcc     3780

agagctgtaa ctgcacaccc agtggcatcc agtgcgctca cagccttgag gcctgcacct     3840

gcacctatga ggacaggacc tacagctacc aggacgtcat ctacaacacc accgatgggc     3900

ttggcgcctg cttgatcgcc atctgcggaa gcaacggcac catcatcagg aaggctgtgg     3960

catgtcctgg aactccagcc acaacgccat tcaccttcac caccgcctgg gtcccccact     4020

ccacgacaag cccggccctc ccggtctcca ccgtgtgtgt ccgcgaggtc tgccgctggt     4080

ccagctggta caatgggcac cgcccagagc ccggcctggg aggcggagac tttgagacgt     4140

ttgaaaacct gaggcagaga gggtaccagg tatgccctgt gctggctgac atcgagtgcc     4200

gggcggcgca gcttcccgac atgccgctgg aggagctggg ccagcaggtg gactgtgacc     4260

gcatgcgggg gctgatgtgc gccaacagcc aacagagtcc cccgctctgt cacgactacg     4320

agctgcgggt tctctgctgc gaatacgtgc cctgtggccc ctccccggcc ccaggcacca     4380

gccctcagcc ctccctcagt gccagcacgg agcctgctgt gcctacccca acccagacca     4440

cagcaaccga aaagaccacc ctatgggtga ccccgagcat ccggtcgacg gcggccctca     4500

cctcgcagac tgggtccagc tcaggccccg tgacggtcac cccctcggcc ccaggtacca     4560

ccacctgcca gccccggtgt cagtggacag agtggtttga tgaggactac cccaagtctg     4620

aacaacttgg aggggacgtt gagtcctacg ataagatcag ggccgctgga gggcacttat     4680

gccagcagcc taaggacata gagtgccagg ccgagagctt ccccaactgg accctggcac     4740

aggtggggca gaaggtgcac tgtgacgtcc acttcggcct ggtgtgcagg aactgggagc     4800

aggagggcgt cttcaagatg tgctacaact acaggatccg ggtcctctgc tgcagtgacg     4860

accactgcag gggacgtgcc acaaccccgc caccgaccac agagctggag acggccacca     4920

ccaccaccac ccaggccctg ttctcaacgc cgcagcctac gagtagcccg gggctgacca     4980

gggctccccc ggccagcacc acagcagtcc ccaccctctc agaaggactg acatccccca     5040

gatacacaag cacccttggt acagccacca cgggaggccc cacgacgcct gcaggctcca     5100

cagaacccac tgtcccaggg gtggccacat ccacccttcc aacacgctca gcccttccag     5160

ggacgacggg gagcttgggc acatggcgcc cctcacagcc acccacgctg gccccaacaa     5220

caatggcaac ctccagagct cgcccgacag gcacagccag caccgcttcc aaagagccgc     5280

tgaccacgag cctggcgcca acactcacga gcgagctgtc cacctctcag gccgagacca     5340

gcacgcccag gacagagacg acaatgagcc ccttgactaa caccaccacc agccagggca     5400

cgacccgctg tcaaccgaag tgtgagtgga cagagtggtt tgacgtggac ttcccaacct     5460

caggggttgc aggcggggac atggaaactt ttgaaaacat cagggctgct gggggcaaga     5520

tgtgctgggc accaaagagc atagagtgcc gggcggagaa ctaccccgag gtaagcatcg     5580

accaggtcgg gcaggtgctg acctgcagcc tggagacggg gctgacctgc aagaacgaag     5640

accagacagg caggttcaac atgtgcttca actacaacgt gcgtgtgctt tgctgtgacg     5700

actacagcca ctgccccagt accccagcca ccagctccac ggccacgccc tcctcaactc     5760

cggggacgac ctggatcctc acaaagccga ccacaacagc cactacgact gcgtccactg     5820

gatccacggc caccccgacc tccaccctga gaacagctcc ccctcccaaa gtgctgacca     5880

ccacggccac cacacccaca gtcaccagct ccaaagccac tccctcctcc agtccaggga     5940

ctgcaaccgc ccttccagca ctgagaagca cagccaccac acccacagct accagcgtta     6000

cacccatccc ctcttcctcc ctgggcacca cctggacccg cctatcacag accaccacac     6060

ccacggccac catgtccaca gccacaccct cctccactcc agagactgcc cacacctcca     6120

cagtgcttac cgccacggcc accacaactg gggccaccgg ctctgtggcc accccctcct     6180

ccaccccagg aacagctcac actaccaaag tgccaactac cacaaccacg ggcttcacag     6240

ccaccccctc ctccagccca gggacggcac tcacgcctcc agtgtggatc agcacaacca     6300

ccacacccac aaccagaggc tccacggtga ccccctcctc catcccgggg accacccaca     6360

ccgccacagt gctgaccacc accaccacaa ctgtggccac tggttctatg gcaacaccct     6420

cctctagcac acagaccagt ggtactcccc catcactgac caccacggcc actacgatca     6480

cggccaccgg ctccaccacc aacccctcct caactcctgg gacaactccc atccccccag     6540

tgctgaccac caccgccacc acacctgcag ccaccagcaa cacagtgact ccctcctctg     6600

ccctagggac cacccacaca cccccagtgc cgaacaccat ggccaccaca cacgggcgat     6660

ccctgccccc cagcagtccc cacacggtgc gcacagcctg gacttcggcc acctcgggca     6720

tcttgggcac cacccacatc acagagcctt ccacggtgac ttcccacacc ctagcagcaa     6780

ccaccggtac cacccagcac tcgactccag ccctttccag ccctcaccct agcagcagaa     6840

ccaccgagtc acccccttct ccagggacga ccaccccggg ccacaccacg gccacctcca     6900

ggaccacagc cacggccaca cccagcaaga cccgcacctc gaccctgctg cccagcagcc     6960

ccacatcggc ccccataacc acggtggtga ccatgggctg tgagccccag tgtgcctggt     7020

cagagtggct ggactacagc taccccatgc cggggccctc tggcggggac tttgacacct     7080

actccaacat ccgtgcggcc ggaggggccg tctgtgagca gcccctgggc ctcgagtgcc     7140

gtgcccaggc ccagcctggt gtccccctgc gggagttggg ccaggtcgtg gaatgcagcc     7200

tggactttgg cctggtctgc aggaaccgtg agcaggtggg gaagttcaag atgtgcttca     7260

actatgaaat ccgtgtgttc tgctgcaact acggccactg ccccagcacc ccggccacca     7320

gctctacggc catgccctcc tccactccgg ggacgacctg gatcctcaca gagctgacca     7380

caacagccac tacgactgag tccactggat ccacggccac cccgtcctcc accccaggga     7440

ccacctggat cctcacagag ccgagcacta cagccaccgt gacggtgccc accggatcca     7500

cggccaccgc ctcctccacc caggcaactg ctggcacccc acatgtgagc accacggcca     7560

cgacacccac agtcaccagc tccaaagcca ctcccttctc cagtccaggg actgcaaccg     7620

cccttccagc actgagaagc acagccacca cacccacagc taccagcttt acagccatcc     7680

cctcctcctc cctgggcacc acctggaccc gcctatcaca gaccaccaca cccacggcca     7740

ccatgtccac agccacaccc tcctccactc cagagactgt ccacacctcc acagtgctta     7800

ccaccacggc caccacaacc ggggccaccg gctctgtggc caccccctcc tccaccccag     7860

gaacagctca cactaccaaa gtgctgacta ccacaaccac gggcttcaca gccaccccct     7920

cctccagccc agggacggca cgcacgcttc cagtgtggat cagcacaacc accacaccca     7980

caaccagagg ttccacggtg accccctcct ccatcccggg gaccacccac acccccacag     8040

tgctgaccac caccaccaca actgtggcca ctggttctat ggcaacaccc tcctctagca     8100

cacagaccag tggtactccc ccatcactga ccaccacggc cactacgatc acggccaccg     8160

gctccaccac caacccctcc tcaactccag ggacaacacc tatcccccca gtgctgacca     8220

ccaccgccac cacacctgca gccaccagca gcacagtgac tccctcctct gccctaggga     8280

ccacccacac acccccagtg ccgaacacca cggccaccac acacgggcga tccctgtccc     8340

ccagcagtcc ccacacggtg cgcacagcct ggacttcggc cacctcaggc accttgggca     8400

ccacccacat cacagagcct tccacgggga cttcccacac cccagcagca accaccggta     8460

ccacccagca ctcgactcca gccctgtcca gccctcaccc tagcagcagg accaccgagt     8520

cacccccttc tccagggacg accaccccgg gccacaccag ggccacctcc aggaccacgg     8580

ccacggccac acccagcaag acccgcacct cgaccctgct gcccagcagc cccacatcgg     8640

ccccaataac cacggtggtg accatgggct gtgagcccca gtgtgcctgg tcagagtggc     8700

tggactacag ctaccccatg ccggggccct ctggcgggga ctttgacacc tactccaaca     8760

tccgtgcggc cggaggggcc gtctgtgagc agcccctggg cctcgagtgc cgtgcccagg     8820

cccagcctgg tgtccccctg cgggagttgg gccaggtcgt ggaatgcagc ctggactttg     8880

gcctggtctg caggaaccgt gagcaggtgg ggaagttcaa gatgtgcttc aactatgaaa     8940

tccgtgtgtt ctgctgcaac tacggccact gccccagcac cccggccacc agctctacgg     9000

ccacgccctc ctccactcca gggacgacct ggatcctcac agagcagacc acagcagcca     9060

ctacgaccgc aaccactgga tccacggcca tcccgtcctc caccccggga acagctcccc     9120

ctcccaaagt gctgaccagc acggccacca cacccacagc caccagttcc aaagccactt     9180

cctcctccag tccaaggact gcaaccaccc ttccagtgct gacaagcaca gccaccaaat     9240

ccacagctac cagctttaca cccatcccct ccttcaccct tgggaccacc gggaccctcc     9300

cagaacagac caccacaccc atggccacca tgtccacaat ccacccctcc tccactccgg     9360

agaccaccca cacctccaca gtgctgacca cgaaggccac cacgacaagg gccaccagtt     9420

ccatgtccac cccctcctcc actccgggga cgacctggat cctcacagag ctgaccacag     9480

cagccactac aactgcagcc actggcccca cggccacccc gtcctccacc ccagggacca     9540

cctggatcct cacagagccc agcactacag ccaccgtgac ggtgcccacc ggatccacgg     9600

ccaccgcctc ctccacccgg gcaactgctg gcaccctcaa agtgctgacc agcacggcca     9660

ccacacccac agtcatcagc tccagagcca ctccctcctc cagtccaggg actgcaaccg     9720

cccttccagc actgagaagc acagccacca cacccacagc taccagcgtt acagccatcc     9780

cctcttcctc cctgggcacc gcctggaccc gcctatcaca gaccaccaca cccacggcca     9840

ccatgtccac agccacaccc tcctctactc cagagactgt ccacacctcc acagtgctta     9900

ccaccacgac caccacaacc agggccaccg gctctgtggc caccccctcc tccaccccag     9960

gaacagctca cactaccaaa gtgccgacta ccacaaccac gggcttcaca gccaccccct    10020

cctccagccc agggacggca ctcacgcctc cagtgtggat cagcacaacc accacaccca    10080

caaccagagg ctccacggtg accccctcct ccatcccggg gaccacccac accgccacag    10140

tgctgaccac caccaccaca actgtggcca ctggttctat ggcaacaccc tcctctagca    10200

cacagaccag tggtactccc ccatcactga ccaccacggc cactacgatc acagccaccg    10260

gctccaccac caacccctcc tcaactccag ggacaactcc catcccccca gtgctgacca    10320

ccaccgccac cacacctgca gccaccagca gcacagtgac tccctcctct gccctaggga    10380

ccacccacac acccccagtg ccgaacacca cggccaccac acacgggcgg tccctgcccc    10440

ccagcagtcc ccacacggtg cgcacagcct ggacttcggc cacctcgggc atcttgggca    10500

ccacccacat cacagagcct tccacggtga cttcccacac cccagcagca accaccagta    10560

ccacccagca ctcgactcca gccctgtcca gccctcaccc tagcagcagg accaccgagt    10620

cacccccttc tccagggacg accaccccgg gccacaccag gggcacctcc aggaccacag    10680

ccacagccac acccagcaag acccgcacct cgaccctgct gcccagcagc cccacatcgg    10740

cccccataac cacggtggtg accacgggct gtgagcccca gtgtgcctgg tcagagtggc    10800

tggactacag ctaccccatg ccggggccct ctggcgggga ctttgacacc tactccaaca    10860

tccgtgcggc cggaggggca gtctgtgagc agcccctggg cctcgagtgc cgtgcccagg    10920

cccagcctgg tgtccccctg cgggagttgg gccaggtcgt ggaatgcagc ctggactttg    10980

gcctggtctg caggaaccgt gagcaggtgg ggaagttcaa gatgtgcttc aactatgaaa    11040

tccgtgtgtt ctgctgcaac tacggccact gccccagcac cccggccacc agctctacgg    11100

ccacgccctc ctcaactccg gggacgacct ggatcctcac aaagctgacc acaacagcca    11160

ctacgactga gtccactgga tccacggcca ccccgtcctc caccccaggg accacctgga    11220

tcctcacaga gccgagcact acagccaccg tgacggtgcc caccggatcc acggccaccg    11280

cctcctccac ccaggcaact gctggcaccc cacatgtgag caccacggcc acgacaccca    11340

cagtcaccag ctccaaagcc actcccttct ccagtccagg gactgcaacc gcccttccag    11400

cactgagaag cacagccacc acacccacag ctaccagctt tacagccatc ccctcctcct    11460

ccctgggcac cacctggacc cgcctatcac agaccaccac acccacggcc accatgtcca    11520

cagccacacc ctcctccact ccagagactg cccacacctc cacagtgctt accaccacgg    11580

ccaccacaac cagggccacc ggctctgtgg ccaccccctc ttccacccca ggaacagctc    11640

acactaccaa agtgccgact accacaacca cgggcttcac agtcaccccc tcctccagcc    11700

cagggacggc acgcacgcct ccagtgtgga tcagcacaac caccacaccc acaaccagtg    11760

gctccacggt gaccccctcc tccgtcccgg ggaccaccca cacccccaca gtgctgacca    11820

ccaccaccac aactgtggcc actggttcta tggcaacacc ctcctctagc acacagacca    11880

gtggtactcc cccatcactg atcaccacgg ccactacgat cacggccacc ggctccacca    11940

ccaacccctc ctcaactcca gggacaacac ctatcccccc agtgctgacc accaccgcca    12000

ccacacctgc agccaccagc agcacagtga ctccctcctc tgccctaggg accacccaca    12060

cacccccagt gccgaacacc acggccacca cacacgggcg atccctgtcc cccagcagtc    12120

cccacacggt gcgcacagcc tggacttcgg ccacctcagg caccttgggc accacccaca    12180

tcacagagcc ttccacgggg acttcccaca ccccagcagc aaccaccggt accacccagc    12240

actcgactcc agccctgtcc agccctcacc ctagcagcag gaccaccgag tcaccccctt    12300

ccccagggac gaccaccccg ggccacacca cggccacctc caggaccacg gccacggcca    12360

cacccagcaa gacccgcacc tcgaccctgc tgcccagcag ccccacatcg gcccccataa    12420

ccacggtggt gaccacgggc tgtgagcccc agtgtgcctg gtcagagtgg ctggactaca    12480

gctaccccat gccggggccc tctggcgggg actttgacac ctactccaac atccgtgcgg    12540

ccggaggggc cgtctgtgag cagcccctgg gcctcgagtg ccgtgcccag gcccagcctg    12600

gtgtccccct gggggagttg ggccaggtcg tggaatgcag cctggacttt ggcctggtct    12660

gcaggaaccg tgagcaggtg gggaagttca agatgtgctt caactatgaa atccgtgtgt    12720

tctgctgcaa ctacggccac tgccccagca ccccggccac cagctctacg gccatgccct    12780

cctccactcc ggggacgacc tggatcctca cagagctgac cacaacagcc actacgactg    12840

catccactgg atccacggcc accccgtcct ccaccccggg aacagctccc cctcccaaag    12900

tgctgaccag cccggccacc acacccacag ccaccagttc caaagccact tcctcctcca    12960

gtccaaggac tgcaaccacc cttccagtgc tgacaagcac agccaccaaa tccacagcta    13020

ccagcgttac acccatcccc tcctccaccc ttgggaccac cgggaccctc ccagaacaga    13080

ccaccacacc cgtggccacc atgtccacaa tccacccctc ctccactccg gagaccaccc    13140

acacctccac agtgctgacc acgaaggcca ccacgacaag ggccaccagt tccacgtcca    13200

ccccctcctc cactccgggg acgacctgga tcctcacaga gctgaccaca gcagccacta    13260

caactgcagc cactggcccc acggccaccc cgtcctccac cccagggacc acctggatcc    13320

tcacagagct gaccacaaca gccactacga ctgcgtccac tggatccacg gccaccccgt    13380

cctccacccc agggaccacc tggatcctca cagagccgag cactacagcc accgtgacgg    13440

tgcccaccgg atccacggcc accgcctcct ccacccaggc aactgctggc accccacatg    13500

tgagcaccac ggccacgaca cccacagtca ccagctccaa agccactccc tcctccagtc    13560

cagggactgc aactgccctt ccagcactga gaagcacagc caccacaccc acagctacca    13620

gctttacagc catcccctcc tcctccctgg gcaccacctg gacccgccta tcacagacca    13680

ccacacccac ggccaccatg tccacagcca caccctcctc cactccagag actgtccaca    13740

cctccacagt gcttaccgcc acggccacca caaccggggc caccggctct gtggccaccc    13800

cctcctccac cccaggaaca gctcacacta ccaaagtgcc gactaccaca accacgggct    13860

tcacagccac cccctcctcc agcccaggga cggcactcac gcctccagtg tggatcagca    13920

caaccaccac acccacaacc accacaccca caaccagtgg ctccacggtg accccctcct    13980

ccatcccggg gaccacccac accgccagag tgctgaccac caccaccaca actgtggcca    14040

ctggttctat ggcaacaccc tcctctagca cacagaccag tggtactccc ccatcactga    14100

ccaccacggc cactacgatc acggccaccg gctccaccac caacccctcc tcaactccag    14160

ggacaacacc catcacccca gtgctgacca gcacggccac cacacccgca gccaccagct    14220

ccaaagccac ttcctcctcc agtccaagga ctgcaaccac ccttccagtg ctgacaagca    14280

cagccacaaa atccacagct accagcttta cacccatccc ctcctccacc ctgtggacca    14340

cgtggaccgt cccagcacag accaccacac ccatgtccac catgtccaca atccacacct    14400

cctctactcc agagaccacc cacacctcca cagtgctgac caccacagcc accatgacaa    14460

gggccaccaa ttccacggcc acaccctcct ccactctggg gacgacccgg atcctcactg    14520

agctgaccac aacagccact acaactgcag ccactggatc cacggccacc ctgtcctcca    14580

ccccagggac cacctggatc ctcacagagc cgagcactat agccaccgtg atggtgccca    14640

ccggttccac ggccaccgcc tcctccactc tgggaacagc tcacaccccc aaagtggtga    14700

ccaccatggc cactatgccc acagccactg cctccacggt tcccagctcg tccaccgtgg    14760

ggaccacccg cacccctgca gtgctcccca gcagcctgcc aaccttcagc gtgtccactg    14820

tgtcctcctc agtcctcacc accctgagac ccactggctt ccccagctcc cacttctcta    14880

ctccctgctt ctgcagggca tttggacagt ttttctcgcc cggggaagtc atctacaata    14940

agaccgaccg agccggctgc catttctacg cagtgtgcaa tcagcactgt gacattgacc    15000

gcttccaggg cgcctgtccc acctccccac cgccagtgtc ctccgccccg ctgtcctcgc    15060

cctcccctgc ccctggctgt gacaatgcca tccctctccg gcaggtgaat gagacctgga    15120

ccctggagaa ctgcacggtg gccaggtgcg tgggtgacaa ccgtgtcgtc ctgctggacc    15180

caaagcctgt ggccaacgtc acctgcgtga acaagcacct gcccatcaaa gtgtcggacc    15240

cgagccagcc ctgtgacttc cactatgagt gcgagtgcat ctgcagcatg tggggcggct    15300

cccactattc cacctttgac ggcacctctt acaccttccg gggcaactgc acctatgtcc    15360

tcatgagaga gatccatgca cgctttggga atctcagcct ctacctggac aaccactact    15420

gcacggcctc tgccactgcc gctgccgccc gctgcccccg cgccctcagc atccactaca    15480

agtccatgga tatcgtcctc actgtcacca tggtgcatgg gaaggaggag ggcctgatcc    15540

tgtttgacca aattccggtg agcagcggtt tcagcaagaa cggcgtgctt gtgtctgtgc    15600

tggggaccac caccatgcgt gtggacattc ctgccctggg cgtgagcgtc accttcaatg    15660

gccaagtctt ccaggcccgg ctgccctaca gcctcttcca caacaacacc gagggccagt    15720

gcggcacctg caccaacaac cagagggacg actgtctcca gcgggacgga accactgccg    15780

ccagttgcaa ggacatggcc aagacgtggc tggtccccga cagcagaaag gatggctgct    15840

gggccccgac tggcacaccc cccactgcca gccccgcagc cccggtgtct agcacaccca    15900

cccccacccc atgcccacca cagccgctct gtgatctgat gctgagccag gtctttgctg    15960

agtgccacaa ccttgtgccc ccgggcccat tcttcaacgc ctgcatcagc gaccactgca    16020

ggggccgcct tgaggtgccc tgccagagcc tggaggctta cgcagagctc tgccgcgccc    16080

ggggagtgtg cagtgactgg cgaggtgcaa ccggtggcct gtgcgacctc acctgcccac    16140

ccaccaaagt gtacaagcca tgcggcccca tacagcctgc cacctgcaac tctaggaacc    16200

agagcccaca gctggagggg atggcggagg gctgcttctg ccctgaggac cagatcctct    16260

tcaacgcaca catgggcatc tgcgtgcagg cctgcccctg cgtgggaccc gatgggtttc    16320

ctaaatttcc cggggagcgg tgggtcagca actgccagtc ctgcgtgtgt gacgagggtt    16380

cagtgtcggt gcagtgcaag cccctgccct gtgacgccca gggtcagccc ccgccgtgca    16440

accgtcccgg cttcgtaacc gtgaccaggc cccgggccga gaacccctgc tgccccgaga    16500

cggtgtgcgt gtgcaacaca accacctgcc cccagagcct gcctgtgtgc ccgccagggc    16560

aggagtccat ctgcacccag gaggagggcg actgctgtcc caccttccgc tgcagacctc    16620

agctgtgttc gtacaatggc accttctacg gggttggtgc aaccttccca ggcgcccttc    16680

cctgccacat gtgtacctgc ctctctgggg acacccagga cccaacggtg caatgtcagg    16740

aggatgcctg caacaatact acctgtcccc agggctttga gtacaagaga gtggccgggc    16800

agtgctgtgg ggagtgcgtc cagaccgcct gcctcacgcc cgatggccag ccagtccagc    16860

tgaatgaaac ctgggtcaac agccatgtgg acaactgcac cgtgtacctc tgtgaggctg    16920

agggtggagt ccatttgctg accccacagc ctgcatcctg cccagatgtg tccagctgca    16980

gggggagcct caggaaaacc ggctgctgct actcctgtga ggaggactcc tgtcaagtcc    17040

gcatcaacac gaccatcctg tggcaccagg gctgcgagac cgaggtcaac atcaccttct    17100

gcgagggctc ctgccccgga gcgtccaagt actcagcaga ggcccaggcc atgcagcacc    17160

agtgcacctg ctgccaggag aggcgggtcc acgaggagac ggtgcccttg cactgtccta    17220

acggctcagc catcctgcac acctacaccc acgtggatga gtgtggctgc acgcccttct    17280

gtgtccctgc gcccatggct cccccacaca cccgtggctt cccggcccag gaggccactg    17340

ctgtctgaga acgttctgcc tccatcccca tgctctgtcc acctggagcc aggatgtgca    17400

ttgtctgatc atgaaaacct tgggcctcct ctgcggagcc ccccggcctg tgtgtggcac    17460

cccgcgctcc gtgctcctgc tgcccacccc gtgggtgaaa ccggccccag aagggtgagg    17520

ggccagcagg acccctttcg ggagggcgcc actcaggagt cctaccctgg gagagcctgt    17580

ggcccacctt ggccttgccc ctccctgatg tcactgggac gccctggaac aaactaagca    17640

tgtgcgggcc tatgtgtccc tgccacggcc ggagcgcccg cgcagcacgg attccagctg    17700

gccacgtccg gccgctgggg cagacaggct ggtccaggca aggccagctg ctgccaggaa    17760

gctgcgacag gcaaggcggc cgcctgtcca tgcctgctgc agggtaactc agggctgagg    17820

tcgcaacggc caggtcagag aggggtcagc atcccaaagc cccctctgct caacccagcc    17880

cagttttgca aataaaccct gagcattgag tacgtt                              17916


<210>  12
<211>  5762
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 
1               5                   10                  15      


Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser 
            20                  25                  30          


Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser 
        35                  40                  45              


Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser 
    50                  55                  60                  


Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp 
65                  70                  75                  80  


Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro 
                85                  90                  95      


Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu 
            100                 105                 110         


Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val 
        115                 120                 125             


Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser 
    130                 135                 140                 


Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser 
145                 150                 155                 160 


Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser 
                165                 170                 175     


Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu 
            180                 185                 190         


Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly 
        195                 200                 205             


Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala 
    210                 215                 220                 


Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro 
225                 230                 235                 240 


Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr 
                245                 250                 255     


Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala 
            260                 265                 270         


Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala 
        275                 280                 285             


Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu 
    290                 295                 300                 


Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg 
305                 310                 315                 320 


Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln 
                325                 330                 335     


Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala 
            340                 345                 350         


Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly 
        355                 360                 365             


Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln 
    370                 375                 380                 


Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe 
385                 390                 395                 400 


Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys 
                405                 410                 415     


Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His 
            420                 425                 430         


Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser 
        435                 440                 445             


Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala 
    450                 455                 460                 


Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala 
465                 470                 475                 480 


Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala 
                485                 490                 495     


Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser 
            500                 505                 510         


Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val 
        515                 520                 525             


Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met 
    530                 535                 540                 


Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly 
545                 550                 555                 560 


Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu 
                565                 570                 575     


Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys 
            580                 585                 590         


Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys 
        595                 600                 605             


Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg 
    610                 615                 620                 


Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn 
625                 630                 635                 640 


Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu 
                645                 650                 655     


Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala 
            660                 665                 670         


Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys 
        675                 680                 685             


Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val 
    690                 695                 700                 


Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val 
705                 710                 715                 720 


Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala 
                725                 730                 735     


Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys 
            740                 745                 750         


Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His 
        755                 760                 765             


Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu 
    770                 775                 780                 


Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val Tyr 
785                 790                 795                 800 


Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu 
                805                 810                 815     


Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys Val 
            820                 825                 830         


Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly Gly 
        835                 840                 845             


Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr Tyr 
    850                 855                 860                 


Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys Arg 
865                 870                 875                 880 


Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys Val 
                885                 890                 895     


Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser 
            900                 905                 910         


Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp 
        915                 920                 925             


Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro Cys 
    930                 935                 940                 


Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val Glu 
945                 950                 955                 960 


Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala Arg 
                965                 970                 975     


Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe 
            980                 985                 990         


Leu Val Ile Glu Thr His Gly Met  Ala Val Ser Trp Asp  Arg Lys Thr 
        995                 1000                 1005             


Ser Val  Phe Ile Arg Leu His  Gln Asp Tyr Lys Gly  Arg Val Cys 
    1010                 1015                 1020             


Gly Leu  Cys Gly Asn Phe Asp  Asp Asn Ala Ile Asn  Asp Phe Ala 
    1025                 1030                 1035             


Thr Arg  Ser Arg Ser Val Val  Gly Asp Ala Leu Glu  Phe Gly Asn 
    1040                 1045                 1050             


Ser Trp  Lys Leu Ser Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys 
    1055                 1060                 1065             


Asp Pro  Cys Thr Ala Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys 
    1070                 1075                 1080             


Gln Cys  Ser Ile Leu His Gly  Pro Thr Phe Ala Ala  Cys Arg Ser 
    1085                 1090                 1095             


Gln Val  Asp Ser Thr Lys Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala 
    1100                 1105                 1110             


Cys Ala  Cys Asp Ser Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala 
    1115                 1120                 1125             


Val Ala  Ala Tyr Ala Gln Ala  Cys His Asp Ala Gly  Leu Cys Val 
    1130                 1135                 1140             


Ser Trp  Arg Thr Pro Asp Thr  Cys Pro Leu Phe Cys  Asp Phe Tyr 
    1145                 1150                 1155             


Asn Pro  His Gly Gly Cys Glu  Trp His Tyr Gln Pro  Cys Gly Ala 
    1160                 1165                 1170             


Pro Cys  Leu Lys Thr Cys Arg  Asn Pro Ser Gly His  Cys Leu Val 
    1175                 1180                 1185             


Asp Leu  Pro Gly Leu Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Ser 
    1190                 1195                 1200             


Gln Pro  Phe Phe Asn Glu Asp  Gln Met Lys Cys Val  Ala Gln Cys 
    1205                 1210                 1215             


Gly Cys  Tyr Asp Lys Asp Gly  Asn Tyr Tyr Asp Val  Gly Ala Arg 
    1220                 1225                 1230             


Val Pro  Thr Ala Glu Asn Cys  Gln Ser Cys Asn Cys  Thr Pro Ser 
    1235                 1240                 1245             


Gly Ile  Gln Cys Ala His Ser  Leu Glu Ala Cys Thr  Cys Thr Tyr 
    1250                 1255                 1260             


Glu Asp  Arg Thr Tyr Ser Tyr  Gln Asp Val Ile Tyr  Asn Thr Thr 
    1265                 1270                 1275             


Asp Gly  Leu Gly Ala Cys Leu  Ile Ala Ile Cys Gly  Ser Asn Gly 
    1280                 1285                 1290             


Thr Ile  Ile Arg Lys Ala Val  Ala Cys Pro Gly Thr  Pro Ala Thr 
    1295                 1300                 1305             


Thr Pro  Phe Thr Phe Thr Thr  Ala Trp Val Pro His  Ser Thr Thr 
    1310                 1315                 1320             


Ser Pro  Ala Leu Pro Val Ser  Thr Val Cys Val Arg  Glu Val Cys 
    1325                 1330                 1335             


Arg Trp  Ser Ser Trp Tyr Asn  Gly His Arg Pro Glu  Pro Gly Leu 
    1340                 1345                 1350             


Gly Gly  Gly Asp Phe Glu Thr  Phe Glu Asn Leu Arg  Gln Arg Gly 
    1355                 1360                 1365             


Tyr Gln  Val Cys Pro Val Leu  Ala Asp Ile Glu Cys  Arg Ala Ala 
    1370                 1375                 1380             


Gln Leu  Pro Asp Met Pro Leu  Glu Glu Leu Gly Gln  Gln Val Asp 
    1385                 1390                 1395             


Cys Asp  Arg Met Arg Gly Leu  Met Cys Ala Asn Ser  Gln Gln Ser 
    1400                 1405                 1410             


Pro Pro  Leu Cys His Asp Tyr  Glu Leu Arg Val Leu  Cys Cys Glu 
    1415                 1420                 1425             


Tyr Val  Pro Cys Gly Pro Ser  Pro Ala Pro Gly Thr  Ser Pro Gln 
    1430                 1435                 1440             


Pro Ser  Leu Ser Ala Ser Thr  Glu Pro Ala Val Pro  Thr Pro Thr 
    1445                 1450                 1455             


Gln Thr  Thr Ala Thr Glu Lys  Thr Thr Leu Trp Val  Thr Pro Ser 
    1460                 1465                 1470             


Ile Arg  Ser Thr Ala Ala Leu  Thr Ser Gln Thr Gly  Ser Ser Ser 
    1475                 1480                 1485             


Gly Pro  Val Thr Val Thr Pro  Ser Ala Pro Gly Thr  Thr Thr Cys 
    1490                 1495                 1500             


Gln Pro  Arg Cys Gln Trp Thr  Glu Trp Phe Asp Glu  Asp Tyr Pro 
    1505                 1510                 1515             


Lys Ser  Glu Gln Leu Gly Gly  Asp Val Glu Ser Tyr  Asp Lys Ile 
    1520                 1525                 1530             


Arg Ala  Ala Gly Gly His Leu  Cys Gln Gln Pro Lys  Asp Ile Glu 
    1535                 1540                 1545             


Cys Gln  Ala Glu Ser Phe Pro  Asn Trp Thr Leu Ala  Gln Val Gly 
    1550                 1555                 1560             


Gln Lys  Val His Cys Asp Val  His Phe Gly Leu Val  Cys Arg Asn 
    1565                 1570                 1575             


Trp Glu  Gln Glu Gly Val Phe  Lys Met Cys Tyr Asn  Tyr Arg Ile 
    1580                 1585                 1590             


Arg Val  Leu Cys Cys Ser Asp  Asp His Cys Arg Gly  Arg Ala Thr 
    1595                 1600                 1605             


Thr Pro  Pro Pro Thr Thr Glu  Leu Glu Thr Ala Thr  Thr Thr Thr 
    1610                 1615                 1620             


Thr Gln  Ala Leu Phe Ser Thr  Pro Gln Pro Thr Ser  Ser Pro Gly 
    1625                 1630                 1635             


Leu Thr  Arg Ala Pro Pro Ala  Ser Thr Thr Ala Val  Pro Thr Leu 
    1640                 1645                 1650             


Ser Glu  Gly Leu Thr Ser Pro  Arg Tyr Thr Ser Thr  Leu Gly Thr 
    1655                 1660                 1665             


Ala Thr  Thr Gly Gly Pro Thr  Thr Pro Ala Gly Ser  Thr Glu Pro 
    1670                 1675                 1680             


Thr Val  Pro Gly Val Ala Thr  Ser Thr Leu Pro Thr  Arg Ser Ala 
    1685                 1690                 1695             


Leu Pro  Gly Thr Thr Gly Ser  Leu Gly Thr Trp Arg  Pro Ser Gln 
    1700                 1705                 1710             


Pro Pro  Thr Leu Ala Pro Thr  Thr Met Ala Thr Ser  Arg Ala Arg 
    1715                 1720                 1725             


Pro Thr  Gly Thr Ala Ser Thr  Ala Ser Lys Glu Pro  Leu Thr Thr 
    1730                 1735                 1740             


Ser Leu  Ala Pro Thr Leu Thr  Ser Glu Leu Ser Thr  Ser Gln Ala 
    1745                 1750                 1755             


Glu Thr  Ser Thr Pro Arg Thr  Glu Thr Thr Met Ser  Pro Leu Thr 
    1760                 1765                 1770             


Asn Thr  Thr Thr Ser Gln Gly  Thr Thr Arg Cys Gln  Pro Lys Cys 
    1775                 1780                 1785             


Glu Trp  Thr Glu Trp Phe Asp  Val Asp Phe Pro Thr  Ser Gly Val 
    1790                 1795                 1800             


Ala Gly  Gly Asp Met Glu Thr  Phe Glu Asn Ile Arg  Ala Ala Gly 
    1805                 1810                 1815             


Gly Lys  Met Cys Trp Ala Pro  Lys Ser Ile Glu Cys  Arg Ala Glu 
    1820                 1825                 1830             


Asn Tyr  Pro Glu Val Ser Ile  Asp Gln Val Gly Gln  Val Leu Thr 
    1835                 1840                 1845             


Cys Ser  Leu Glu Thr Gly Leu  Thr Cys Lys Asn Glu  Asp Gln Thr 
    1850                 1855                 1860             


Gly Arg  Phe Asn Met Cys Phe  Asn Tyr Asn Val Arg  Val Leu Cys 
    1865                 1870                 1875             


Cys Asp  Asp Tyr Ser His Cys  Pro Ser Thr Pro Ala  Thr Ser Ser 
    1880                 1885                 1890             


Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 
    1895                 1900                 1905             


Lys Pro  Thr Thr Thr Ala Thr  Thr Thr Ala Ser Thr  Gly Ser Thr 
    1910                 1915                 1920             


Ala Thr  Pro Thr Ser Thr Leu  Arg Thr Ala Pro Pro  Pro Lys Val 
    1925                 1930                 1935             


Leu Thr  Thr Thr Ala Thr Thr  Pro Thr Val Thr Ser  Ser Lys Ala 
    1940                 1945                 1950             


Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Thr Ala Leu  Pro Ala Leu 
    1955                 1960                 1965             


Arg Ser  Thr Ala Thr Thr Pro  Thr Ala Thr Ser Val  Thr Pro Ile 
    1970                 1975                 1980             


Pro Ser  Ser Ser Leu Gly Thr  Thr Trp Thr Arg Leu  Ser Gln Thr 
    1985                 1990                 1995             


Thr Thr  Pro Thr Ala Thr Met  Ser Thr Ala Thr Pro  Ser Ser Thr 
    2000                 2005                 2010             


Pro Glu  Thr Ala His Thr Ser  Thr Val Leu Thr Ala  Thr Ala Thr 
    2015                 2020                 2025             


Thr Thr  Gly Ala Thr Gly Ser  Val Ala Thr Pro Ser  Ser Thr Pro 
    2030                 2035                 2040             


Gly Thr  Ala His Thr Thr Lys  Val Pro Thr Thr Thr  Thr Thr Gly 
    2045                 2050                 2055             


Phe Thr  Ala Thr Pro Ser Ser  Ser Pro Gly Thr Ala  Leu Thr Pro 
    2060                 2065                 2070             


Pro Val  Trp Ile Ser Thr Thr  Thr Thr Pro Thr Thr  Arg Gly Ser 
    2075                 2080                 2085             


Thr Val  Thr Pro Ser Ser Ile  Pro Gly Thr Thr His  Thr Ala Thr 
    2090                 2095                 2100             


Val Leu  Thr Thr Thr Thr Thr  Thr Val Ala Thr Gly  Ser Met Ala 
    2105                 2110                 2115             


Thr Pro  Ser Ser Ser Thr Gln  Thr Ser Gly Thr Pro  Pro Ser Leu 
    2120                 2125                 2130             


Thr Thr  Thr Ala Thr Thr Ile  Thr Ala Thr Gly Ser  Thr Thr Asn 
    2135                 2140                 2145             


Pro Ser  Ser Thr Pro Gly Thr  Thr Pro Ile Pro Pro  Val Leu Thr 
    2150                 2155                 2160             


Thr Thr  Ala Thr Thr Pro Ala  Ala Thr Ser Asn Thr  Val Thr Pro 
    2165                 2170                 2175             


Ser Ser  Ala Leu Gly Thr Thr  His Thr Pro Pro Val  Pro Asn Thr 
    2180                 2185                 2190             


Met Ala  Thr Thr His Gly Arg  Ser Leu Pro Pro Ser  Ser Pro His 
    2195                 2200                 2205             


Thr Val  Arg Thr Ala Trp Thr  Ser Ala Thr Ser Gly  Ile Leu Gly 
    2210                 2215                 2220             


Thr Thr  His Ile Thr Glu Pro  Ser Thr Val Thr Ser  His Thr Leu 
    2225                 2230                 2235             


Ala Ala  Thr Thr Gly Thr Thr  Gln His Ser Thr Pro  Ala Leu Ser 
    2240                 2245                 2250             


Ser Pro  His Pro Ser Ser Arg  Thr Thr Glu Ser Pro  Pro Ser Pro 
    2255                 2260                 2265             


Gly Thr  Thr Thr Pro Gly His  Thr Thr Ala Thr Ser  Arg Thr Thr 
    2270                 2275                 2280             


Ala Thr  Ala Thr Pro Ser Lys  Thr Arg Thr Ser Thr  Leu Leu Pro 
    2285                 2290                 2295             


Ser Ser  Pro Thr Ser Ala Pro  Ile Thr Thr Val Val  Thr Met Gly 
    2300                 2305                 2310             


Cys Glu  Pro Gln Cys Ala Trp  Ser Glu Trp Leu Asp  Tyr Ser Tyr 
    2315                 2320                 2325             


Pro Met  Pro Gly Pro Ser Gly  Gly Asp Phe Asp Thr  Tyr Ser Asn 
    2330                 2335                 2340             


Ile Arg  Ala Ala Gly Gly Ala  Val Cys Glu Gln Pro  Leu Gly Leu 
    2345                 2350                 2355             


Glu Cys  Arg Ala Gln Ala Gln  Pro Gly Val Pro Leu  Arg Glu Leu 
    2360                 2365                 2370             


Gly Gln  Val Val Glu Cys Ser  Leu Asp Phe Gly Leu  Val Cys Arg 
    2375                 2380                 2385             


Asn Arg  Glu Gln Val Gly Lys  Phe Lys Met Cys Phe  Asn Tyr Glu 
    2390                 2395                 2400             


Ile Arg  Val Phe Cys Cys Asn  Tyr Gly His Cys Pro  Ser Thr Pro 
    2405                 2410                 2415             


Ala Thr  Ser Ser Thr Ala Met  Pro Ser Ser Thr Pro  Gly Thr Thr 
    2420                 2425                 2430             


Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala Thr Thr  Thr Glu Ser 
    2435                 2440                 2445             


Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 
    2450                 2455                 2460             


Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr Val Thr  Val Pro Thr 
    2465                 2470                 2475             


Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln Ala Thr  Ala Gly Thr 
    2480                 2485                 2490             


Pro His  Val Ser Thr Thr Ala  Thr Thr Pro Thr Val  Thr Ser Ser 
    2495                 2500                 2505             


Lys Ala  Thr Pro Phe Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro 
    2510                 2515                 2520             


Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr Ala Thr  Ser Phe Thr 
    2525                 2530                 2535             


Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr Trp Thr  Arg Leu Ser 
    2540                 2545                 2550             


Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser 
    2555                 2560                 2565             


Ser Thr  Pro Glu Thr Val His  Thr Ser Thr Val Leu  Thr Thr Thr 
    2570                 2575                 2580             


Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser 
    2585                 2590                 2595             


Thr Pro  Gly Thr Ala His Thr  Thr Lys Val Leu Thr  Thr Thr Thr 
    2600                 2605                 2610             


Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Arg 
    2615                 2620                 2625             


Thr Leu  Pro Val Trp Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg 
    2630                 2635                 2640             


Gly Ser  Thr Val Thr Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr 
    2645                 2650                 2655             


Pro Thr  Val Leu Thr Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser 
    2660                 2665                 2670             


Met Ala  Thr Pro Ser Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro 
    2675                 2680                 2685             


Ser Leu  Thr Thr Thr Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr 
    2690                 2695                 2700             


Thr Asn  Pro Ser Ser Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val 
    2705                 2710                 2715             


Leu Thr  Thr Thr Ala Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val 
    2720                 2725                 2730             


Thr Pro  Ser Ser Ala Leu Gly  Thr Thr His Thr Pro  Pro Val Pro 
    2735                 2740                 2745             


Asn Thr  Thr Ala Thr Thr His  Gly Arg Ser Leu Ser  Pro Ser Ser 
    2750                 2755                 2760             


Pro His  Thr Val Arg Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Thr 
    2765                 2770                 2775             


Leu Gly  Thr Thr His Ile Thr  Glu Pro Ser Thr Gly  Thr Ser His 
    2780                 2785                 2790             


Thr Pro  Ala Ala Thr Thr Gly  Thr Thr Gln His Ser  Thr Pro Ala 
    2795                 2800                 2805             


Leu Ser  Ser Pro His Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro 
    2810                 2815                 2820             


Ser Pro  Gly Thr Thr Thr Pro  Gly His Thr Arg Ala  Thr Ser Arg 
    2825                 2830                 2835             


Thr Thr  Ala Thr Ala Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu 
    2840                 2845                 2850             


Leu Pro  Ser Ser Pro Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr 
    2855                 2860                 2865             


Met Gly  Cys Glu Pro Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr 
    2870                 2875                 2880             


Ser Tyr  Pro Met Pro Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr 
    2885                 2890                 2895             


Ser Asn  Ile Arg Ala Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu 
    2900                 2905                 2910             


Gly Leu  Glu Cys Arg Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg 
    2915                 2920                 2925             


Glu Leu  Gly Gln Val Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val 
    2930                 2935                 2940             


Cys Arg  Asn Arg Glu Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn 
    2945                 2950                 2955             


Tyr Glu  Ile Arg Val Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser 
    2960                 2965                 2970             


Thr Pro  Ala Thr Ser Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly 
    2975                 2980                 2985             


Thr Thr  Trp Ile Leu Thr Glu  Gln Thr Thr Ala Ala  Thr Thr Thr 
    2990                 2995                 3000             


Ala Thr  Thr Gly Ser Thr Ala  Ile Pro Ser Ser Thr  Pro Gly Thr 
    3005                 3010                 3015             


Ala Pro  Pro Pro Lys Val Leu  Thr Ser Thr Ala Thr  Thr Pro Thr 
    3020                 3025                 3030             


Ala Thr  Ser Ser Lys Ala Thr  Ser Ser Ser Ser Pro  Arg Thr Ala 
    3035                 3040                 3045             


Thr Thr  Leu Pro Val Leu Thr  Ser Thr Ala Thr Lys  Ser Thr Ala 
    3050                 3055                 3060             


Thr Ser  Phe Thr Pro Ile Pro  Ser Phe Thr Leu Gly  Thr Thr Gly 
    3065                 3070                 3075             


Thr Leu  Pro Glu Gln Thr Thr  Thr Pro Met Ala Thr  Met Ser Thr 
    3080                 3085                 3090             


Ile His  Pro Ser Ser Thr Pro  Glu Thr Thr His Thr  Ser Thr Val 
    3095                 3100                 3105             


Leu Thr  Thr Lys Ala Thr Thr  Thr Arg Ala Thr Ser  Ser Met Ser 
    3110                 3115                 3120             


Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Leu 
    3125                 3130                 3135             


Thr Thr  Ala Ala Thr Thr Thr  Ala Ala Thr Gly Pro  Thr Ala Thr 
    3140                 3145                 3150             


Pro Ser  Ser Thr Pro Gly Thr  Thr Trp Ile Leu Thr  Glu Pro Ser 
    3155                 3160                 3165             


Thr Thr  Ala Thr Val Thr Val  Pro Thr Gly Ser Thr  Ala Thr Ala 
    3170                 3175                 3180             


Ser Ser  Thr Arg Ala Thr Ala  Gly Thr Leu Lys Val  Leu Thr Ser 
    3185                 3190                 3195             


Thr Ala  Thr Thr Pro Thr Val  Ile Ser Ser Arg Ala  Thr Pro Ser 
    3200                 3205                 3210             


Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr 
    3215                 3220                 3225             


Ala Thr  Thr Pro Thr Ala Thr  Ser Val Thr Ala Ile  Pro Ser Ser 
    3230                 3235                 3240             


Ser Leu  Gly Thr Ala Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro 
    3245                 3250                 3255             


Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr 
    3260                 3265                 3270             


Val His  Thr Ser Thr Val Leu  Thr Thr Thr Thr Thr  Thr Thr Arg 
    3275                 3280                 3285             


Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala 
    3290                 3295                 3300             


His Thr  Thr Lys Val Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala 
    3305                 3310                 3315             


Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp 
    3320                 3325                 3330             


Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg Gly Ser  Thr Val Thr 
    3335                 3340                 3345             


Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Thr  Val Leu Thr 
    3350                 3355                 3360             


Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 
    3365                 3370                 3375             


Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 
    3380                 3385                 3390             


Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 
    3395                 3400                 3405             


Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val Leu Thr  Thr Thr Ala 
    3410                 3415                 3420             


Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val Thr Pro  Ser Ser Ala 
    3425                 3430                 3435             


Leu Gly  Thr Thr His Thr Pro  Pro Val Pro Asn Thr  Thr Ala Thr 
    3440                 3445                 3450             


Thr His  Gly Arg Ser Leu Pro  Pro Ser Ser Pro His  Thr Val Arg 
    3455                 3460                 3465             


Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Ile Leu Gly  Thr Thr His 
    3470                 3475                 3480             


Ile Thr  Glu Pro Ser Thr Val  Thr Ser His Thr Pro  Ala Ala Thr 
    3485                 3490                 3495             


Thr Ser  Thr Thr Gln His Ser  Thr Pro Ala Leu Ser  Ser Pro His 
    3500                 3505                 3510             


Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro Ser Pro  Gly Thr Thr 
    3515                 3520                 3525             


Thr Pro  Gly His Thr Arg Gly  Thr Ser Arg Thr Thr  Ala Thr Ala 
    3530                 3535                 3540             


Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu Leu Pro  Ser Ser Pro 
    3545                 3550                 3555             


Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr Thr Gly  Cys Glu Pro 
    3560                 3565                 3570             


Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr Ser Tyr  Pro Met Pro 
    3575                 3580                 3585             


Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr Ser Asn  Ile Arg Ala 
    3590                 3595                 3600             


Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu Gly Leu  Glu Cys Arg 
    3605                 3610                 3615             


Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg Glu Leu  Gly Gln Val 
    3620                 3625                 3630             


Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val Cys Arg  Asn Arg Glu 
    3635                 3640                 3645             


Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn Tyr Glu  Ile Arg Val 
    3650                 3655                 3660             


Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser Thr Pro  Ala Thr Ser 
    3665                 3670                 3675             


Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 
    3680                 3685                 3690             


Thr Lys  Leu Thr Thr Thr Ala  Thr Thr Thr Glu Ser  Thr Gly Ser 
    3695                 3700                 3705             


Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 
    3710                 3715                 3720             


Glu Pro  Ser Thr Thr Ala Thr  Val Thr Val Pro Thr  Gly Ser Thr 
    3725                 3730                 3735             


Ala Thr  Ala Ser Ser Thr Gln  Ala Thr Ala Gly Thr  Pro His Val 
    3740                 3745                 3750             


Ser Thr  Thr Ala Thr Thr Pro  Thr Val Thr Ser Ser  Lys Ala Thr 
    3755                 3760                 3765             


Pro Phe  Ser Ser Pro Gly Thr  Ala Thr Ala Leu Pro  Ala Leu Arg 
    3770                 3775                 3780             


Ser Thr  Ala Thr Thr Pro Thr  Ala Thr Ser Phe Thr  Ala Ile Pro 
    3785                 3790                 3795             


Ser Ser  Ser Leu Gly Thr Thr  Trp Thr Arg Leu Ser  Gln Thr Thr 
    3800                 3805                 3810             


Thr Pro  Thr Ala Thr Met Ser  Thr Ala Thr Pro Ser  Ser Thr Pro 
    3815                 3820                 3825             


Glu Thr  Ala His Thr Ser Thr  Val Leu Thr Thr Thr  Ala Thr Thr 
    3830                 3835                 3840             


Thr Arg  Ala Thr Gly Ser Val  Ala Thr Pro Ser Ser  Thr Pro Gly 
    3845                 3850                 3855             


Thr Ala  His Thr Thr Lys Val  Pro Thr Thr Thr Thr  Thr Gly Phe 
    3860                 3865                 3870             


Thr Val  Thr Pro Ser Ser Ser  Pro Gly Thr Ala Arg  Thr Pro Pro 
    3875                 3880                 3885             


Val Trp  Ile Ser Thr Thr Thr  Thr Pro Thr Thr Ser  Gly Ser Thr 
    3890                 3895                 3900             


Val Thr  Pro Ser Ser Val Pro  Gly Thr Thr His Thr  Pro Thr Val 
    3905                 3910                 3915             


Leu Thr  Thr Thr Thr Thr Thr  Val Ala Thr Gly Ser  Met Ala Thr 
    3920                 3925                 3930             


Pro Ser  Ser Ser Thr Gln Thr  Ser Gly Thr Pro Pro  Ser Leu Ile 
    3935                 3940                 3945             


Thr Thr  Ala Thr Thr Ile Thr  Ala Thr Gly Ser Thr  Thr Asn Pro 
    3950                 3955                 3960             


Ser Ser  Thr Pro Gly Thr Thr  Pro Ile Pro Pro Val  Leu Thr Thr 
    3965                 3970                 3975             


Thr Ala  Thr Thr Pro Ala Ala  Thr Ser Ser Thr Val  Thr Pro Ser 
    3980                 3985                 3990             


Ser Ala  Leu Gly Thr Thr His  Thr Pro Pro Val Pro  Asn Thr Thr 
    3995                 4000                 4005             


Ala Thr  Thr His Gly Arg Ser  Leu Ser Pro Ser Ser  Pro His Thr 
    4010                 4015                 4020             


Val Arg  Thr Ala Trp Thr Ser  Ala Thr Ser Gly Thr  Leu Gly Thr 
    4025                 4030                 4035             


Thr His  Ile Thr Glu Pro Ser  Thr Gly Thr Ser His  Thr Pro Ala 
    4040                 4045                 4050             


Ala Thr  Thr Gly Thr Thr Gln  His Ser Thr Pro Ala  Leu Ser Ser 
    4055                 4060                 4065             


Pro His  Pro Ser Ser Arg Thr  Thr Glu Ser Pro Pro  Ser Pro Gly 
    4070                 4075                 4080             


Thr Thr  Thr Pro Gly His Thr  Thr Ala Thr Ser Arg  Thr Thr Ala 
    4085                 4090                 4095             


Thr Ala  Thr Pro Ser Lys Thr  Arg Thr Ser Thr Leu  Leu Pro Ser 
    4100                 4105                 4110             


Ser Pro  Thr Ser Ala Pro Ile  Thr Thr Val Val Thr  Thr Gly Cys 
    4115                 4120                 4125             


Glu Pro  Gln Cys Ala Trp Ser  Glu Trp Leu Asp Tyr  Ser Tyr Pro 
    4130                 4135                 4140             


Met Pro  Gly Pro Ser Gly Gly  Asp Phe Asp Thr Tyr  Ser Asn Ile 
    4145                 4150                 4155             


Arg Ala  Ala Gly Gly Ala Val  Cys Glu Gln Pro Leu  Gly Leu Glu 
    4160                 4165                 4170             


Cys Arg  Ala Gln Ala Gln Pro  Gly Val Pro Leu Gly  Glu Leu Gly 
    4175                 4180                 4185             


Gln Val  Val Glu Cys Ser Leu  Asp Phe Gly Leu Val  Cys Arg Asn 
    4190                 4195                 4200             


Arg Glu  Gln Val Gly Lys Phe  Lys Met Cys Phe Asn  Tyr Glu Ile 
    4205                 4210                 4215             


Arg Val  Phe Cys Cys Asn Tyr  Gly His Cys Pro Ser  Thr Pro Ala 
    4220                 4225                 4230             


Thr Ser  Ser Thr Ala Met Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 
    4235                 4240                 4245             


Ile Leu  Thr Glu Leu Thr Thr  Thr Ala Thr Thr Thr  Ala Ser Thr 
    4250                 4255                 4260             


Gly Ser  Thr Ala Thr Pro Ser  Ser Thr Pro Gly Thr  Ala Pro Pro 
    4265                 4270                 4275             


Pro Lys  Val Leu Thr Ser Pro  Ala Thr Thr Pro Thr  Ala Thr Ser 
    4280                 4285                 4290             


Ser Lys  Ala Thr Ser Ser Ser  Ser Pro Arg Thr Ala  Thr Thr Leu 
    4295                 4300                 4305             


Pro Val  Leu Thr Ser Thr Ala  Thr Lys Ser Thr Ala  Thr Ser Val 
    4310                 4315                 4320             


Thr Pro  Ile Pro Ser Ser Thr  Leu Gly Thr Thr Gly  Thr Leu Pro 
    4325                 4330                 4335             


Glu Gln  Thr Thr Thr Pro Val  Ala Thr Met Ser Thr  Ile His Pro 
    4340                 4345                 4350             


Ser Ser  Thr Pro Glu Thr Thr  His Thr Ser Thr Val  Leu Thr Thr 
    4355                 4360                 4365             


Lys Ala  Thr Thr Thr Arg Ala  Thr Ser Ser Thr Ser  Thr Pro Ser 
    4370                 4375                 4380             


Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr Glu Leu  Thr Thr Ala 
    4385                 4390                 4395             


Ala Thr  Thr Thr Ala Ala Thr  Gly Pro Thr Ala Thr  Pro Ser Ser 
    4400                 4405                 4410             


Thr Pro  Gly Thr Thr Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala 
    4415                 4420                 4425             


Thr Thr  Thr Ala Ser Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr 
    4430                 4435                 4440             


Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr 
    4445                 4450                 4455             


Val Thr  Val Pro Thr Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln 
    4460                 4465                 4470             


Ala Thr  Ala Gly Thr Pro His  Val Ser Thr Thr Ala  Thr Thr Pro 
    4475                 4480                 4485             


Thr Val  Thr Ser Ser Lys Ala  Thr Pro Ser Ser Ser  Pro Gly Thr 
    4490                 4495                 4500             


Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr 
    4505                 4510                 4515             


Ala Thr  Ser Phe Thr Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr 
    4520                 4525                 4530             


Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser 
    4535                 4540                 4545             


Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr Val His  Thr Ser Thr 
    4550                 4555                 4560             


Val Leu  Thr Ala Thr Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val 
    4565                 4570                 4575             


Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala His Thr  Thr Lys Val 
    4580                 4585                 4590             


Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser 
    4595                 4600                 4605             


Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp Ile Ser  Thr Thr Thr 
    4610                 4615                 4620             


Thr Pro  Thr Thr Thr Thr Pro  Thr Thr Ser Gly Ser  Thr Val Thr 
    4625                 4630                 4635             


Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Arg  Val Leu Thr 
    4640                 4645                 4650             


Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 
    4655                 4660                 4665             


Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 
    4670                 4675                 4680             


Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 
    4685                 4690                 4695             


Thr Pro  Gly Thr Thr Pro Ile  Thr Pro Val Leu Thr  Ser Thr Ala 
    4700                 4705                 4710             


Thr Thr  Pro Ala Ala Thr Ser  Ser Lys Ala Thr Ser  Ser Ser Ser 
    4715                 4720                 4725             


Pro Arg  Thr Ala Thr Thr Leu  Pro Val Leu Thr Ser  Thr Ala Thr 
    4730                 4735                 4740             


Lys Ser  Thr Ala Thr Ser Phe  Thr Pro Ile Pro Ser  Ser Thr Leu 
    4745                 4750                 4755             


Trp Thr  Thr Trp Thr Val Pro  Ala Gln Thr Thr Thr  Pro Met Ser 
    4760                 4765                 4770             


Thr Met  Ser Thr Ile His Thr  Ser Ser Thr Pro Glu  Thr Thr His 
    4775                 4780                 4785             


Thr Ser  Thr Val Leu Thr Thr  Thr Ala Thr Met Thr  Arg Ala Thr 
    4790                 4795                 4800             


Asn Ser  Thr Ala Thr Pro Ser  Ser Thr Leu Gly Thr  Thr Arg Ile 
    4805                 4810                 4815             


Leu Thr  Glu Leu Thr Thr Thr  Ala Thr Thr Thr Ala  Ala Thr Gly 
    4820                 4825                 4830             


Ser Thr  Ala Thr Leu Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 
    4835                 4840                 4845             


Thr Glu  Pro Ser Thr Ile Ala  Thr Val Met Val Pro  Thr Gly Ser 
    4850                 4855                 4860             


Thr Ala  Thr Ala Ser Ser Thr  Leu Gly Thr Ala His  Thr Pro Lys 
    4865                 4870                 4875             


Val Val  Thr Thr Met Ala Thr  Met Pro Thr Ala Thr  Ala Ser Thr 
    4880                 4885                 4890             


Val Pro  Ser Ser Ser Thr Val  Gly Thr Thr Arg Thr  Pro Ala Val 
    4895                 4900                 4905             


Leu Pro  Ser Ser Leu Pro Thr  Phe Ser Val Ser Thr  Val Ser Ser 
    4910                 4915                 4920             


Ser Val  Leu Thr Thr Leu Arg  Pro Thr Gly Phe Pro  Ser Ser His 
    4925                 4930                 4935             


Phe Ser  Thr Pro Cys Phe Cys  Arg Ala Phe Gly Gln  Phe Phe Ser 
    4940                 4945                 4950             


Pro Gly  Glu Val Ile Tyr Asn  Lys Thr Asp Arg Ala  Gly Cys His 
    4955                 4960                 4965             


Phe Tyr  Ala Val Cys Asn Gln  His Cys Asp Ile Asp  Arg Phe Gln 
    4970                 4975                 4980             


Gly Ala  Cys Pro Thr Ser Pro  Pro Pro Val Ser Ser  Ala Pro Leu 
    4985                 4990                 4995             


Ser Ser  Pro Ser Pro Ala Pro  Gly Cys Asp Asn Ala  Ile Pro Leu 
    5000                 5005                 5010             


Arg Gln  Val Asn Glu Thr Trp  Thr Leu Glu Asn Cys  Thr Val Ala 
    5015                 5020                 5025             


Arg Cys  Val Gly Asp Asn Arg  Val Val Leu Leu Asp  Pro Lys Pro 
    5030                 5035                 5040             


Val Ala  Asn Val Thr Cys Val  Asn Lys His Leu Pro  Ile Lys Val 
    5045                 5050                 5055             


Ser Asp  Pro Ser Gln Pro Cys  Asp Phe His Tyr Glu  Cys Glu Cys 
    5060                 5065                 5070             


Ile Cys  Ser Met Trp Gly Gly  Ser His Tyr Ser Thr  Phe Asp Gly 
    5075                 5080                 5085             


Thr Ser  Tyr Thr Phe Arg Gly  Asn Cys Thr Tyr Val  Leu Met Arg 
    5090                 5095                 5100             


Glu Ile  His Ala Arg Phe Gly  Asn Leu Ser Leu Tyr  Leu Asp Asn 
    5105                 5110                 5115             


His Tyr  Cys Thr Ala Ser Ala  Thr Ala Ala Ala Ala  Arg Cys Pro 
    5120                 5125                 5130             


Arg Ala  Leu Ser Ile His Tyr  Lys Ser Met Asp Ile  Val Leu Thr 
    5135                 5140                 5145             


Val Thr  Met Val His Gly Lys  Glu Glu Gly Leu Ile  Leu Phe Asp 
    5150                 5155                 5160             


Gln Ile  Pro Val Ser Ser Gly  Phe Ser Lys Asn Gly  Val Leu Val 
    5165                 5170                 5175             


Ser Val  Leu Gly Thr Thr Thr  Met Arg Val Asp Ile  Pro Ala Leu 
    5180                 5185                 5190             


Gly Val  Ser Val Thr Phe Asn  Gly Gln Val Phe Gln  Ala Arg Leu 
    5195                 5200                 5205             


Pro Tyr  Ser Leu Phe His Asn  Asn Thr Glu Gly Gln  Cys Gly Thr 
    5210                 5215                 5220             


Cys Thr  Asn Asn Gln Arg Asp  Asp Cys Leu Gln Arg  Asp Gly Thr 
    5225                 5230                 5235             


Thr Ala  Ala Ser Cys Lys Asp  Met Ala Lys Thr Trp  Leu Val Pro 
    5240                 5245                 5250             


Asp Ser  Arg Lys Asp Gly Cys  Trp Ala Pro Thr Gly  Thr Pro Pro 
    5255                 5260                 5265             


Thr Ala  Ser Pro Ala Ala Pro  Val Ser Ser Thr Pro  Thr Pro Thr 
    5270                 5275                 5280             


Pro Cys  Pro Pro Gln Pro Leu  Cys Asp Leu Met Leu  Ser Gln Val 
    5285                 5290                 5295             


Phe Ala  Glu Cys His Asn Leu  Val Pro Pro Gly Pro  Phe Phe Asn 
    5300                 5305                 5310             


Ala Cys  Ile Ser Asp His Cys  Arg Gly Arg Leu Glu  Val Pro Cys 
    5315                 5320                 5325             


Gln Ser  Leu Glu Ala Tyr Ala  Glu Leu Cys Arg Ala  Arg Gly Val 
    5330                 5335                 5340             


Cys Ser  Asp Trp Arg Gly Ala  Thr Gly Gly Leu Cys  Asp Leu Thr 
    5345                 5350                 5355             


Cys Pro  Pro Thr Lys Val Tyr  Lys Pro Cys Gly Pro  Ile Gln Pro 
    5360                 5365                 5370             


Ala Thr  Cys Asn Ser Arg Asn  Gln Ser Pro Gln Leu  Glu Gly Met 
    5375                 5380                 5385             


Ala Glu  Gly Cys Phe Cys Pro  Glu Asp Gln Ile Leu  Phe Asn Ala 
    5390                 5395                 5400             


His Met  Gly Ile Cys Val Gln  Ala Cys Pro Cys Val  Gly Pro Asp 
    5405                 5410                 5415             


Gly Phe  Pro Lys Phe Pro Gly  Glu Arg Trp Val Ser  Asn Cys Gln 
    5420                 5425                 5430             


Ser Cys  Val Cys Asp Glu Gly  Ser Val Ser Val Gln  Cys Lys Pro 
    5435                 5440                 5445             


Leu Pro  Cys Asp Ala Gln Gly  Gln Pro Pro Pro Cys  Asn Arg Pro 
    5450                 5455                 5460             


Gly Phe  Val Thr Val Thr Arg  Pro Arg Ala Glu Asn  Pro Cys Cys 
    5465                 5470                 5475             


Pro Glu  Thr Val Cys Val Cys  Asn Thr Thr Thr Cys  Pro Gln Ser 
    5480                 5485                 5490             


Leu Pro  Val Cys Pro Pro Gly  Gln Glu Ser Ile Cys  Thr Gln Glu 
    5495                 5500                 5505             


Glu Gly  Asp Cys Cys Pro Thr  Phe Arg Cys Arg Pro  Gln Leu Cys 
    5510                 5515                 5520             


Ser Tyr  Asn Gly Thr Phe Tyr  Gly Val Gly Ala Thr  Phe Pro Gly 
    5525                 5530                 5535             


Ala Leu  Pro Cys His Met Cys  Thr Cys Leu Ser Gly  Asp Thr Gln 
    5540                 5545                 5550             


Asp Pro  Thr Val Gln Cys Gln  Glu Asp Ala Cys Asn  Asn Thr Thr 
    5555                 5560                 5565             


Cys Pro  Gln Gly Phe Glu Tyr  Lys Arg Val Ala Gly  Gln Cys Cys 
    5570                 5575                 5580             


Gly Glu  Cys Val Gln Thr Ala  Cys Leu Thr Pro Asp  Gly Gln Pro 
    5585                 5590                 5595             


Val Gln  Leu Asn Glu Thr Trp  Val Asn Ser His Val  Asp Asn Cys 
    5600                 5605                 5610             


Thr Val  Tyr Leu Cys Glu Ala  Glu Gly Gly Val His  Leu Leu Thr 
    5615                 5620                 5625             


Pro Gln  Pro Ala Ser Cys Pro  Asp Val Ser Ser Cys  Arg Gly Ser 
    5630                 5635                 5640             


Leu Arg  Lys Thr Gly Cys Cys  Tyr Ser Cys Glu Glu  Asp Ser Cys 
    5645                 5650                 5655             


Gln Val  Arg Ile Asn Thr Thr  Ile Leu Trp His Gln  Gly Cys Glu 
    5660                 5665                 5670             


Thr Glu  Val Asn Ile Thr Phe  Cys Glu Gly Ser Cys  Pro Gly Ala 
    5675                 5680                 5685             


Ser Lys  Tyr Ser Ala Glu Ala  Gln Ala Met Gln His  Gln Cys Thr 
    5690                 5695                 5700             


Cys Cys  Gln Glu Arg Arg Val  His Glu Glu Thr Val  Pro Leu His 
    5705                 5710                 5715             


Cys Pro  Asn Gly Ser Ala Ile  Leu His Thr Tyr Thr  His Val Asp 
    5720                 5725                 5730             


Glu Cys  Gly Cys Thr Pro Phe  Cys Val Pro Ala Pro  Met Ala Pro 
    5735                 5740                 5745             


Pro His  Thr Arg Gly Phe Pro  Ala Gln Glu Ala Thr  Ala Val 
    5750                 5755                 5760         


<210>  13
<211>  4018
<212>  DNA
<213>  Homo sapiens

<400>  13
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc     2220

ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt     2280

gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag     2340

ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca     2400

ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc     2460

cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag     2520

gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct     2580

ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg     2640

gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa     2700

aaccttcctc aggaccctgg tccgaggtgt ccctgagtat ggctgcgtgg tgaacttgcg     2760

gaagacagtg gtgaacttcc ctgtagaaga cgaggccctg ggtggcacgg cttttgttca     2820

gatgccggcc cacggcctat tcccctggtg cggcctgctg ctggataccc ggaccctgga     2880

ggtgcagagc gactactcca gctatgcccg gacctccatc agagccagtc tcaccttcaa     2940

ccgcggcttc aaggctggga ggaacatgcg tcgcaaactc tttggggtct tgcggctgaa     3000

gtgtcacagc ctgtttctgg atttgcaggt gaacagcctc cagacggtgt gcaccaacat     3060

ctacaagatc ctcctgctgc aggcgtacag gtttcacgca tgtgtgctgc agctcccatt     3120

tcatcagcaa gtttggaaga accccacatt tttcctgcgc gtcatctctg acacggcctc     3180

cctctgctac tccatcctga aagccaagaa cgcagggatg tcgctggggg ccaagggcgc     3240

cgccggccct ctgccctccg aggccgtgca gtggctgtgc caccaagcat tcctgctcaa     3300

gctgactcga caccgtgtca cctacgtgcc actcctgggg tcactcagga cagcccagac     3360

gcagctgagt cggaagctcc cggggacgac gctgactgcc ctggaggccg cagccaaccc     3420

ggcactgccc tcagacttca agaccatcct ggactgatgg ccacccgccc acagccaggc     3480

cgagagcaga caccagcagc cctgtcacgc cgggctctac gtcccaggga gggaggggcg     3540

gcccacaccc aggcccgcac cgctgggagt ctgaggcctg agtgagtgtt tggccgaggc     3600

ctgcatgtcc ggctgaaggc tgagtgtccg gctgaggcct gagcgagtgt ccagccaagg     3660

gctgagtgtc cagcacacct gccgtcttca cttccccaca ggctggcgct cggctccacc     3720

ccagggccag cttttcctca ccaggagccc ggcttccact ccccacatag gaatagtcca     3780

tccccagatt cgccattgtt cacccctcgc cctgccctcc tttgccttcc acccccacca     3840

tccaggtgga gaccctgaga aggaccctgg gagctctggg aatttggagt gaccaaaggt     3900

gtgccctgta cacaggcgag gaccctgcac ctggatgggg gtccctgtgg gtcaaattgg     3960

ggggaggtgc tgtgggagta aaatactgaa tatatgagtt tttcagtttt gaaaaaaa       4018


<210>  14
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  15
<211>  3829
<212>  DNA
<213>  Homo sapiens

<400>  15
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc     2220

ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt     2280

gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag     2340

ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca     2400

ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc     2460

cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag     2520

gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct     2580

ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg     2640

gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa     2700

aaccttcctc agctatgccc ggacctccat cagagccagt ctcaccttca accgcggctt     2760

caaggctggg aggaacatgc gtcgcaaact ctttggggtc ttgcggctga agtgtcacag     2820

cctgtttctg gatttgcagg tgaacagcct ccagacggtg tgcaccaaca tctacaagat     2880

cctcctgctg caggcgtaca ggtttcacgc atgtgtgctg cagctcccat ttcatcagca     2940

agtttggaag aaccccacat ttttcctgcg cgtcatctct gacacggcct ccctctgcta     3000

ctccatcctg aaagccaaga acgcagggat gtcgctgggg gccaagggcg ccgccggccc     3060

tctgccctcc gaggccgtgc agtggctgtg ccaccaagca ttcctgctca agctgactcg     3120

acaccgtgtc acctacgtgc cactcctggg gtcactcagg acagcccaga cgcagctgag     3180

tcggaagctc ccggggacga cgctgactgc cctggaggcc gcagccaacc cggcactgcc     3240

ctcagacttc aagaccatcc tggactgatg gccacccgcc cacagccagg ccgagagcag     3300

acaccagcag ccctgtcacg ccgggctcta cgtcccaggg agggaggggc ggcccacacc     3360

caggcccgca ccgctgggag tctgaggcct gagtgagtgt ttggccgagg cctgcatgtc     3420

cggctgaagg ctgagtgtcc ggctgaggcc tgagcgagtg tccagccaag ggctgagtgt     3480

ccagcacacc tgccgtcttc acttccccac aggctggcgc tcggctccac cccagggcca     3540

gcttttcctc accaggagcc cggcttccac tccccacata ggaatagtcc atccccagat     3600

tcgccattgt tcacccctcg ccctgccctc ctttgccttc cacccccacc atccaggtgg     3660

agaccctgag aaggaccctg ggagctctgg gaatttggag tgaccaaagg tgtgccctgt     3720

acacaggcga ggaccctgca cctggatggg ggtccctgtg ggtcaaattg gggggaggtg     3780

ctgtgggagt aaaatactga atatatgagt ttttcagttt tgaaaaaaa                 3829


<210>  16
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


<210>  17
<211>  5030
<212>  DNA
<213>  Homo sapiens

<400>  17
attgaggagc agaaggagta gggtgcgggg gaggaggagg agcgccttta gtgctgcagc       60

agctgctgct ctgattggcc cggtggttca gctgcttccc tggaacaaaa ggtcaaagtg      120

gactgcagtg taaatgtaga gaagcagccg ataaaatagc attgcctgaa gaagtttgga      180

ggctgagagc agcagtagac tggccaactg cagagcaagt tgtttctcca gccgtgcggt      240

gcagcctcat gcccccaacc cagcttagcc actgtaagaa gacgttcact gtacagacga      300

ccaaacttgc cgtggaagag acagttgtga gattcccttg caaatttaca tacgagaatg      360

gcttgtgaaa tcatgcctct gcaaagttca caggaagatg aaagacctct gtcacctttc      420

tatttgagtg ctcatgtacc ccaagtcagc aatgtgtctg caaccggaga actcttagaa      480

agaaccatcc gatcagctgt agaacaacat ctttttgatg ttaataactc tggaggtcaa      540

agttcagagg actcagaatc tggaacacta tcagcatctt ctgccacatc tgccagacag      600

cgccgccgcc agtccaagga gcaggatgaa gttcgacatg ggagagacaa gggacttatc      660

aacaaagaaa atactccttc tgggttcaac caccttgatg attgtatttt gaatactcag      720

gaagtcgaaa aggtacacaa aaatactttt ggttgtgctg gagaaaggag caagcctaaa      780

cgtcagaaat ccagtactaa actttctgag cttcatgaca atcaggacgg tcttgtgaat      840

atggaaagtc tcaattccac acgatctcat gagagaactg gacctgatga ttttgaatgg      900

atgtctgatg aaaggaaagg aaatgaaaaa gatggtggac acactcagca ttttgagagc      960

cccacaatga agatccagga gcatcccagc ctatctgaca ccaaacagca gagaaatcaa     1020

gatgccggtg accaggagga gagctttgtc tccgaagtgc cccagtcgga cctgactgca     1080

ttgtgtgatg aaaagaactg ggaagagcct atccctgctt tctcctcctg gcagcgggag     1140

aacagtgact ctgatgaagc ccacctctcg ccgcaggctg ggcgcctgat ccgtcagctg     1200

ctggacgaag acagcgaccc catgctctct cctcggttct acgcttatgg gcagagcagg     1260

caatacctgg atgacacaga agtgcctcct tccccaccaa actcccattc tttcatgagg     1320

cggcgaagct cctctctggg gtcctatgat gatgagcaag aggacctgac acctgcccag     1380

ctcacacgaa ggattcagag ccttaaaaag aagatccgga agtttgaaga tagattcgaa     1440

gaagagaaga agtacagacc ttcccacagt gacaaagcag ccaatccgga ggttctgaaa     1500

tggacaaatg accttgccaa attccggaga caacttaaag aatcaaaact aaagatatct     1560

gaagaggacc taactcccag gatgcggcag cgaagcaaca cactccccaa gagttttggt     1620

tcccaacttg agaaagaaga tgagaagaag caagagctgg tggataaagc aataaagccc     1680

agtgttgaag ccacattgga atctattcag aggaagctcc aggagaagcg agcggaaagc     1740

agccgccctg aggacattaa ggatatgacc aaagaccaga ttgctaatga gaaagtggct     1800

ctgcagaaag ctctgttata ttatgaaagc attcatggac ggccggtaac aaagaacgaa     1860

cggcaggtga tgaagccact atacgacagg taccggctgg tcaaacagat cctctcccga     1920

gctaacacca tacccatcat tggttccccc tccagcaagc ggagaagccc tttgctgcag     1980

ccaattatcg agggcgaaac tgcttccttc ttcaaggaga taaaggaaga agaggagggg     2040

tcagaagacg atagcaatgt gaagccagac ttcatggtca ctctgaaaac cgatttcagt     2100

gcacgatgct ttctggacca attcgaagat gacgctgatg gatttatttc cccaatggat     2160

gataaaatac catcaaaatg cagccaggac acagggcttt caaatctcca tgctgcctca     2220

atacctgaac tcctggaaca cctccaggaa atgagagaag aaaagaaaag gattcgaaag     2280

aaacttcggg attttgaaga caactttttc agacagaatg gaagaaatgt ccagaaggaa     2340

gaccgcactc ctatggctga agaatacagt gaatataagc acataaaggc gaaactgagg     2400

ctcctggagg tgctcatcag caagagagac actgattcca agtccatgtg aggggcatgg     2460

ccaagcacag ggggctggca gctgcggtga gagtttactg tccccagaga aagtgcagct     2520

ctggaaggca gccttggggc tggccctgca aagcatgcag cccttctgcc tctagaccat     2580

ttggcatcgg ctcctgtttc cattgcctgc cttagaaact ggctggaaga agacaatgtg     2640

acctgactta ggcattttgt aattggaaag tcaagactgc agtatgtgca catgcgcacg     2700

cgcatgcacg cacacacaca cacagtagtg gagctttcct aacactagca gagattaatc     2760

actacattag acaacactca tctacagaga atatacactg ttcttccctg gataactgag     2820

aaacaagaga ccattctctg tctaactgtg ataaaaacaa gctcaggact ttattctata     2880

gagcaaactt gctgtggagg gccatgctct ccttggaccc agttaactgc aaacgtgcat     2940

tggagcccta tttgctgccg ctgccattct agtgaccttt ccacagagct gcgccttcct     3000

cacgtgtgtg aaaggttttc cccttcagcc ctcaggtaga tggaagctgc atctgcccac     3060

gatggcagtg cagtcatcat cttcaggatg tttcttcagg acttcctcag ctgacaagga     3120

attttggtcc ctgcctagga ccgggtcatc tgcagaggac agagagatgg taagcagctg     3180

tatgaatgct gattttaaaa ccaggtcatg ggagaagagc ctggagattc tttcctgaac     3240

actgactgca cttaccagtc tgattttatc gtcaaacacc aagccaggct agcatgctca     3300

tggcaatctg tttggggctg ttttgttgtg gcactagcca aacataaagg ggcttaagtc     3360

agcctgcata cagaggatcg gggagagaag gggcctgtgt tctcagcctc ctgagtactt     3420

accagagttt aattttttta aaaaaaatct gcactaaaat ccccaaactg acaggtaaat     3480

gtagccctca gagctcagcc caaggcagaa tctaaatcac actattttcg agatcatgta     3540

taaaaagaaa aaaaagaagt catgctgtgt ggccaattat aatttttttc aaagactttg     3600

tcacaaaact gtctatatta gacattttgg agggaccagg aaatgtaaga caccaaatcc     3660

tccatctctt cagtgtgcct gatgtcacct catgatttgc tgttactttt ttaactcctg     3720

cgccaaggac agtgggttct gtgtccacct ttgtgctttg cgaggccgag cccaggcatc     3780

tgctcgcctg ccacggctga ccagagaagg tgcttcagga gctctgcctt agacgacgtg     3840

ttacagtatg aacacacagc agaggcaccc tcgtatgttt tgaaagttgc cttctgaaag     3900

ggcacagttt taaggaaaag aaaaagaatg taaaactata ctgacccgtt ttcagtttta     3960

aagggtcgtg agaaactggc tggtccaatg ggatttacag caacattttc cattgctgaa     4020

gtgaggtagc agctctcttc tgtcagctga atgttaagga tggggaaaaa gaatgccttt     4080

aagtttgctc ttaatcgtat ggaagcttga gctatgtgtt ggaagtgccc tggttttaat     4140

ccatacacaa agacggtaca taatcctaca ggtttaaatg tacataaaaa tatagtttgg     4200

aattctttgc tctactgttt acattgcaga ttgctataat ttcaaggagt gagattataa     4260

ataaaatgat gcactttagg atgtttccta tttttgaaat ctgaacatga atcattcaca     4320

tgaccaaaaa ttgtgttttt ttaaaaatac atgtctagtc tgtcctttaa tagctctctt     4380

aaataagcta tgatattaat cagatcatta ccagttagct tttaaagcac atttgtttaa     4440

gactatgttt ttggaaaaat acgctacaga attttttttt aagctacaaa taaatgagat     4500

gctactaatt gttttggaat ctgttgtttc tgccaaaggt aaattaacta aagatttatt     4560

caggaatccc catttgaatt tgtatgattc aataaaagaa aacaccaagt aagttatata     4620

aaataaattg tgtatgagat gttgtgtttt cctttgtaat ttccactaac taactaacta     4680

acttatattc ttcatggaat ggagcccaga agaaatgaga ggaagccctt ttcacactag     4740

atcttatttg aagaaatgtt tgttagtcag tcagtcagtg gtttctggct ctgccgaggg     4800

agatgtgttc cccagcaacc atttctgcag cccagaatct caaggcacta gaggcggtgt     4860

cttaattaat tggcttcaca aagacaaaat gctctggact gggatttttc ctttgctgtg     4920

ttgggaatat gtgtttatta attagcacat gccaacaaaa taaatgtcaa gagttatttc     4980

ataagtgtaa gtaaacttaa gaattaaaga gtgcagactt ataattttca                5030


<210>  18
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ser Gln Glu Asp Glu Arg 
1               5                   10                  15      


Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gln Val Ser Asn 
            20                  25                  30          


Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser Ala Val 
        35                  40                  45              


Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser Ser Glu 
    50                  55                  60                  


Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg 
65                  70                  75                  80  


Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His Gly Arg 
                85                  90                  95      


Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His 
            100                 105                 110         


Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val His Lys 
        115                 120                 125             


Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gln Lys 
    130                 135                 140                 


Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val 
145                 150                 155                 160 


Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro 
                165                 170                 175     


Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp 
            180                 185                 190         


Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile Gln Glu 
        195                 200                 205             


His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp Ala Gly 
    210                 215                 220                 


Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp Leu Thr 
225                 230                 235                 240 


Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala Phe Ser 
                245                 250                 255     


Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro 
            260                 265                 270         


Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser Asp Pro 
        275                 280                 285             


Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln Tyr Leu 
    290                 295                 300                 


Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met 
305                 310                 315                 320 


Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln Glu Asp 
                325                 330                 335     


Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys Lys Lys 
            340                 345                 350         


Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro 
        355                 360                 365             


Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn 
    370                 375                 380                 


Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu Lys Ile 
385                 390                 395                 400 


Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn Thr Leu 
                405                 410                 415     


Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys Lys Gln 
            420                 425                 430         


Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr Leu Glu 
        435                 440                 445             


Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser Arg Pro 
    450                 455                 460                 


Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu Lys Val 
465                 470                 475                 480 


Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly Arg Pro 
                485                 490                 495     


Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp Arg Tyr 
            500                 505                 510         


Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro Ile Ile 
        515                 520                 525             


Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu Gln Pro Ile Ile 
    530                 535                 540                 


Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu Ile Lys Glu Glu Glu Glu 
545                 550                 555                 560 


Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe Met Val Thr Leu 
                565                 570                 575     


Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln Phe Glu Asp Asp 
            580                 585                 590         


Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile Pro Ser Lys Cys 
        595                 600                 605             


Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala Ser Ile Pro Glu 
    610                 615                 620                 


Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys Lys Arg Ile Arg 
625                 630                 635                 640 


Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg Gln Asn Gly Arg 
                645                 650                 655     


Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu Glu Tyr Ser Glu 
            660                 665                 670         


Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu Val Leu Ile Ser 
        675                 680                 685             


Lys Arg Asp Thr Asp Ser Lys Ser Met 
    690                 695         


<210>  19
<211>  8005
<212>  DNA
<213>  Homo sapiens

<400>  19
aagaaaccgg ccaggtgtgg cctaggcgcc cagtgccagc ggggaggaga ctcgctccgc       60

cgccgaccaa caccaacacc cagctccgac gcagctcctc tgcgcccttg ccgccctccg      120

agccacagct ttcctcccgc tcctgccccc ggcccgtcgc cgtctccgcg ctcgcagcgg      180

cctcgggagg gcccaggtag cgagcagcga cctcgcgagc cttccgcact cccgcccggt      240

tccccggccg tccgcctatc cttggccccc tccgctttct ccgcgccggc ccgcctcgct      300

tatgcctcgg cgctgagccg ctctcccgat tgcccgccga catgagctgc aacggaggct      360

cccacccgcg gatcaacact ctgggccgca tgatccgcgc cgagtctggc ccggacctgc      420

gctacgaggt gaccagcggc ggcgggggca ccagcaggat gtactattct cggcgcggcg      480

tgatcaccga ccagaactcg gacggctact gtcaaaccgg cacgatgtcc aggcaccaga      540

accagaacac catccaggag ctgctgcaga actgctccga ctgcttgatg cgagcagagc      600

tcatcgtgca gcctgaattg aagtatggag atggaataca actgactcgg agtcgagaat      660

tggatgagtg ttttgcccag gccaatgacc aaatggaaat cctcgacagc ttgatcagag      720

agatgcggca gatgggccag ccctgtgatg cttaccagaa aaggcttctt cagctccaag      780

agcaaatgcg agccctttat aaagccatca gtgtccctcg agtccgcagg gccagctcca      840

agggtggtgg aggctacact tgtcagagtg gctctggctg ggatgagttc accaaacatg      900

tcaccagtga atgtttgggg tggatgaggc agcaaagggc ggagatggac atggtggcct      960

ggggtgtgga cctggcctca gtggagcagc acattaacag ccaccggggc atccacaact     1020

ccatcggcga ctatcgctgg cagctggaca aaatcaaagc cgacctgcgc gagaaatctg     1080

cgatctacca gttggaggag gagtatgaaa acctgctgaa agcgtccttt gagaggatgg     1140

atcacctgcg acagctgcag aacatcattc aggccacgtc cagggagatc atgtggatca     1200

atgactgcga ggaggaggag ctgctgtacg actggagcga caagaacacc aacatcgctc     1260

agaaacagga ggccttctcc atacgcatga gtcaactgga agttaaagaa aaagagctca     1320

ataagctgaa acaagaaagt gaccaacttg tcctcaatca gcatccagct tcagacaaaa     1380

ttgaggccta tatggacact ctgcagacgc agtggagttg gattcttcag atcaccaagt     1440

gcattgatgt tcatctgaaa gaaaatgctg cctactttca gttttttgaa gaggcgcagt     1500

ctactgaagc atacctgaag gggctccagg actccatcag gaagaagtac ccctgcgaca     1560

agaacatgcc cctgcagcac ctgctggaac agatcaagga gctggagaaa gaacgagaga     1620

aaatccttga atacaagcgt caggtgcaga acttggtaaa caagtctaag aagattgtac     1680

agctgaagcc tcgtaaccca gactacagaa gcaataaacc cattattctc agagctctct     1740

gtgactacaa acaagatcag aaaatcgtgc ataaggggga tgagtgtatc ctgaaggaca     1800

acaacgagcg cagcaagtgg tacgtgacgg gcccgggagg cgttgacatg cttgttccct     1860

ctgtggggct gatcatccct cctccgaacc cactggccgt ggacctctct tgcaagattg     1920

agcagtacta cgaagccatc ttggctctgt ggaaccagct ctacatcaac atgaagagcc     1980

tggtgtcctg gcactactgc atgattgaca tagagaagat cagggccatg acaatcgcca     2040

agctgaaaac aatgcggcag gaagattaca tgaagacgat agccgacctt gagttacatt     2100

accaagagtt catcagaaat agccaaggct cagagatgtt tggagatgat gacaagcgga     2160

aaatacagtc tcagttcacc gatgcccaga agcattacca gaccctggtc attcagctcc     2220

ctggctatcc ccagcaccag acagtgacca caactgaaat cactcatcat ggaacctgcc     2280

aagatgtcaa ccataataaa gtaattgaaa ccaacagaga aaatgacaag caagaaacat     2340

ggatgctgat ggagctgcag aagattcgca ggcagataga gcactgcgag ggcaggatga     2400

ctctcaaaaa cctccctcta gcagaccagg gatcttctca ccacatcaca gtgaaaatta     2460

acgagcttaa gagtgtgcag aatgattcac aagcaattgc tgaggttctc aaccagctta     2520

aagatatgct tgccaacttc agaggttctg aaaagtactg ctatttacag aatgaagtat     2580

ttggactatt tcagaaactg gaaaatatca atggtgttac agatggctac ttaaatagct     2640

tatgcacagt aagggcactg ctccaggcta ttctccaaac agaagacatg ttaaaggttt     2700

atgaagccag gctcactgag gaggaaactg tctgcctgga cctggataaa gtggaagctt     2760

accgctgtgg actgaagaaa ataaaaaatg acttgaactt gaagaagtcg ttgttggcca     2820

ctatgaagac agaactacag aaagcccagc agatccactc tcagacttca cagcagtatc     2880

cactttatga tctggacttg ggcaagttcg gtgaaaaagt cacacagctg acagaccgct     2940

ggcaaaggat agataaacag atcgacttta ggttatggga cctggagaaa caaatcaagc     3000

aattgaggaa ttatcgtgat aactatcagg ctttctgcaa gtggctctat gatgctaaac     3060

gccgccagga ttccttagaa tccatgaaat ttggagattc caacacagtc atgcggtttt     3120

tgaatgagca gaagaacttg cacagtgaaa tatctggcaa acgagacaaa tcagaggaag     3180

tacaaaaaat tgctgaactt tgcgccaatt caattaagga ttatgagctc cagctggcct     3240

catacacctc aggactggaa actctgctga acatacctat caagaggacc atgattcagt     3300

ccccttctgg ggtgattctg caagaggctg cagatgttca tgctcggtac attgaactac     3360

ttacaagatc tggagactat tacaggttct taagtgagat gctgaagagt ttggaagatc     3420

tgaagctgaa aaataccaag atcgaagttt tggaagagga gctcagactg gcccgagatg     3480

ccaactcgga aaactgtaat aagaacaaat tcctggatca gaacctgcag aaataccagg     3540

cagagtgttc ccagttcaaa gcgaagcttg cgagcctgga ggagctgaag agacaggctg     3600

agctggatgg gaagtcggct aagcaaaatc tagacaagtg ctacggccaa ataaaagaac     3660

tcaatgagaa gatcacccga ctgacttatg agattgaaga tgaaaagaga agaagaaaat     3720

ctgtggaaga cagatttgac caacagaaga atgactatga ccaactgcag aaagcaaggc     3780

aatgtgaaaa ggagaacctt ggttggcaga aattagagtc tgagaaagcc atcaaggaga     3840

aggagtacga gattgaaagg ttgagggttc tactgcagga agaaggcacc cggaagagag     3900

aatatgaaaa tgagctggca aaggcatcta ataggattca ggaatcaaag aatcagtgta     3960

ctcaggtggt acaggaaaga gagagccttc tggtgaaaat caaagtcctg gagcaagaca     4020

aggcaaggct gcagaggctg gaggatgagc tgaatcgtgc aaaatcaact ctagaggcag     4080

aaaccagggt gaaacagcgc ctggagtgtg agaaacagca aattcagaat gacctgaatc     4140

agtggaagac tcaatattcc cgcaaggagg aggctattag gaagatagaa tcggaaagag     4200

aaaagagtga gagagagaag aacagtctta ggagtgagat cgaaagactc caagcagaga     4260

tcaagagaat tgaagagagg tgcaggcgta agctggagga ttctaccagg gagacacagt     4320

cacagttaga aacagaacgc tcccgatatc agagggagat tgataaactc agacagcgcc     4380

catatgggtc ccatcgagag acccagactg agtgtgagtg gaccgttgac acctccaagc     4440

tggtgtttga tgggctgagg aagaaggtga cagcaatgca gctctatgag tgtcagctga     4500

tcgacaaaac aaccttggac aaactattga aggggaagaa gtcagtggaa gaagttgctt     4560

ctgaaatcca gccattcctt cggggtgcag gatctatcgc tggagcatct gcttctccta     4620

aggaaaaata ctctttggta gaggccaaga gaaagaaatt aatcagccca gaatccacag     4680

tcatgcttct ggaggcccag gcagctacag gtggtataat tgatccccat cggaatgaga     4740

agctgactgt cgacagtgcc atagctcggg acctcattga cttcgatgac cgtcagcaga     4800

tatatgcagc agaaaaagct atcactggtt ttgatgatcc attttcaggc aagacagtat     4860

ctgtttcaga agccatcaag aaaaatttga ttgatagaga aaccggaatg cgcctgctgg     4920

aagcccagat tgcttcaggg ggtgtagtag accctgtgaa cagtgtcttt ttgccaaaag     4980

atgtcgcctt ggcccggggg ctgattgata gagatttgta tcgatccctg aatgatcccc     5040

gagatagtca gaaaaacttt gtggatccag tcaccaaaaa gaaggtcagt tacgtgcagc     5100

tgaaggaacg gtgcagaatc gaaccacata ctggtctgct cttgctttca gtacagaaga     5160

gaagcatgtc cttccaagga atcagacaac ctgtgaccgt cactgagcta gtagattctg     5220

gtatattgag accgtccact gtcaatgaac tggaatctgg tcagatttct tatgacgagg     5280

ttggtgagag aattaaggac ttcctccagg gttcaagctg catagcaggc atatacaatg     5340

agaccacaaa acagaagctt ggcatttatg aggccatgaa aattggctta gtccgacctg     5400

gtactgctct ggagttgctg gaagcccaag cagctactgg ctttatagtg gatcctgtta     5460

gcaacttgag gttaccagtg gaggaagcct acaagagagg tctggtgggc attgagttca     5520

aagagaagct cctgtctgca gaacgagctg tcactgggta taatgatcct gaaacaggaa     5580

acatcatctc tttgttccaa gccatgaata aggaactcat cgaaaagggc cacggtattc     5640

gcttattaga agcacagatc gcaaccgggg ggatcattga cccaaaggag agccatcgtt     5700

taccagttga catagcatat aagaggggct atttcaatga ggaactcagt gagattctct     5760

cagatccaag tgatgatacc aaaggatttt ttgaccccaa cactgaagaa aatcttacct     5820

atctgcaact aaaagaaaga tgcattaagg atgaggaaac agggctctgt cttctgcctc     5880

tgaaagaaaa gaagaaacag gtgcagacat cacaaaagaa taccctcagg aagcgtagag     5940

tggtcatagt tgacccagaa accaataaag aaatgtctgt tcaggaggcc tacaagaagg     6000

gcctaattga ttatgaaacc ttcaaagaac tgtgtgagca ggaatgtgaa tgggaagaaa     6060

taaccatcac gggatcagat ggctccacca gggtggtcct ggtagataga aagacaggca     6120

gtcagtatga tattcaagat gctattgaca agggccttgt tgacaggaag ttctttgatc     6180

agtaccgatc cggcagcctc agcctcactc aatttgctga catgatctcc ttgaaaaatg     6240

gtgtcggcac cagcagcagc atgggcagtg gtgtcagcga tgatgttttt agcagctccc     6300

gacatgaatc agtaagtaag atttccacca tatccagcgt caggaattta accataagga     6360

gcagctcttt ttcagacacc ctggaagaat cgagccccat tgcagccatc tttgacacag     6420

aaaacctgga gaaaatctcc attacagaag gtatagagcg gggcatcgtt gacagcatca     6480

cgggtcagag gcttctggag gctcaggcct gcacaggtgg catcatccac ccaaccacgg     6540

gccagaagct gtcacttcag gacgcagtct cccagggtgt gattgaccaa gacatggcca     6600

ccaggctgaa gcctgctcag aaagccttca taggcttcga gggtgtgaag ggaaagaaga     6660

agatgtcagc agcagaggca gtgaaagaaa aatggctccc gtatgaggct ggccagcgct     6720

tcctggagtt ccagtacctc acgggaggtc ttgttgaccc ggaagtgcat gggaggataa     6780

gcaccgaaga agccatccgg aaggggttca tagatggccg cgccgcacag aggctgcaag     6840

acaccagcag ctatgccaaa atcctgacct gccccaaaac caaattaaaa atatcctata     6900

aggatgccat aaatcgctcc atggtagaag atatcactgg gctgcgcctt ctggaagccg     6960

cctccgtgtc gtccaagggc ttacccagcc cttacaacat gtcttcggct ccggggtccc     7020

gctccggctc ccgctcggga tctcgctccg gatctcgctc cgggtcccgc agtgggtccc     7080

ggagaggaag ctttgacgcc acagggaatt cttcctactc ttattcctac tcatttagca     7140

gtagttctat tgggcactag tagtcagttg ggagtggttg ctataccttg acttcattta     7200

tatgaatttc cactttatta aataatagaa aagaaaatcc cggtgcttgc agtagagtga     7260

taggacattc tatgcttaca gaaaatatag ccatgattga aatcaaatag taaaggctgt     7320

tctggctttt tatcttctta gctcatctta aataagcagt acacttggat gcagtgcgtc     7380

tgaagtgcta atcagttgta acaatagcac aaatcgaact taggatttgt ttcttctctt     7440

ctgtgtttcg atttttgatc aattctttaa ttttggaagc ctataataca gttttctatt     7500

cttggagata aaaattaaat ggatcactga tattttagtc attctgcttc tcatctaaat     7560

atttccatat tctgtattag gagaaaatta ccctcccagc accagccccc ctctcaaacc     7620

cccaacccaa aaccaagcat tttggaatga gtctccttta gtttcagagt gtggattgta     7680

taacccatat actcttcgat gtacttgttt ggtttggtat taatttgact gtgcatgaca     7740

gcggcaatct tttctttggt caaagttttc tgtttatttt gcttgtcata ttcgatgtac     7800

tttaaggtgt ctttatgaag tttgctattc tggcaataaa cttttagact tttgaagtgt     7860

ttgtgtttta atttaatatg tttataagca tgtataaaca tttagcatat ttttatcata     7920

ggtctaaaaa tatttgttta ctaaatacct gtgaagaaat accattaaaa aactatttgg     7980

ttctgaattc ttactagaaa aaaaa                                           8005


<210>  20
<211>  2272
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Ala  Ser Asn Arg Ile Gln  Glu Ser Lys 
    1190                 1195                 1200             


Asn Gln  Cys Thr Gln Val Val  Gln Glu Arg Glu Ser  Leu Leu Val 
    1205                 1210                 1215             


Lys Ile  Lys Val Leu Glu Gln  Asp Lys Ala Arg Leu  Gln Arg Leu 
    1220                 1225                 1230             


Glu Asp  Glu Leu Asn Arg Ala  Lys Ser Thr Leu Glu  Ala Glu Thr 
    1235                 1240                 1245             


Arg Val  Lys Gln Arg Leu Glu  Cys Glu Lys Gln Gln  Ile Gln Asn 
    1250                 1255                 1260             


Asp Leu  Asn Gln Trp Lys Thr  Gln Tyr Ser Arg Lys  Glu Glu Ala 
    1265                 1270                 1275             


Ile Arg  Lys Ile Glu Ser Glu  Arg Glu Lys Ser Glu  Arg Glu Lys 
    1280                 1285                 1290             


Asn Ser  Leu Arg Ser Glu Ile  Glu Arg Leu Gln Ala  Glu Ile Lys 
    1295                 1300                 1305             


Arg Ile  Glu Glu Arg Cys Arg  Arg Lys Leu Glu Asp  Ser Thr Arg 
    1310                 1315                 1320             


Glu Thr  Gln Ser Gln Leu Glu  Thr Glu Arg Ser Arg  Tyr Gln Arg 
    1325                 1330                 1335             


Glu Ile  Asp Lys Leu Arg Gln  Arg Pro Tyr Gly Ser  His Arg Glu 
    1340                 1345                 1350             


Thr Gln  Thr Glu Cys Glu Trp  Thr Val Asp Thr Ser  Lys Leu Val 
    1355                 1360                 1365             


Phe Asp  Gly Leu Arg Lys Lys  Val Thr Ala Met Gln  Leu Tyr Glu 
    1370                 1375                 1380             


Cys Gln  Leu Ile Asp Lys Thr  Thr Leu Asp Lys Leu  Leu Lys Gly 
    1385                 1390                 1395             


Lys Lys  Ser Val Glu Glu Val  Ala Ser Glu Ile Gln  Pro Phe Leu 
    1400                 1405                 1410             


Arg Gly  Ala Gly Ser Ile Ala  Gly Ala Ser Ala Ser  Pro Lys Glu 
    1415                 1420                 1425             


Lys Tyr  Ser Leu Val Glu Ala  Lys Arg Lys Lys Leu  Ile Ser Pro 
    1430                 1435                 1440             


Glu Ser  Thr Val Met Leu Leu  Glu Ala Gln Ala Ala  Thr Gly Gly 
    1445                 1450                 1455             


Ile Ile  Asp Pro His Arg Asn  Glu Lys Leu Thr Val  Asp Ser Ala 
    1460                 1465                 1470             


Ile Ala  Arg Asp Leu Ile Asp  Phe Asp Asp Arg Gln  Gln Ile Tyr 
    1475                 1480                 1485             


Ala Ala  Glu Lys Ala Ile Thr  Gly Phe Asp Asp Pro  Phe Ser Gly 
    1490                 1495                 1500             


Lys Thr  Val Ser Val Ser Glu  Ala Ile Lys Lys Asn  Leu Ile Asp 
    1505                 1510                 1515             


Arg Glu  Thr Gly Met Arg Leu  Leu Glu Ala Gln Ile  Ala Ser Gly 
    1520                 1525                 1530             


Gly Val  Val Asp Pro Val Asn  Ser Val Phe Leu Pro  Lys Asp Val 
    1535                 1540                 1545             


Ala Leu  Ala Arg Gly Leu Ile  Asp Arg Asp Leu Tyr  Arg Ser Leu 
    1550                 1555                 1560             


Asn Asp  Pro Arg Asp Ser Gln  Lys Asn Phe Val Asp  Pro Val Thr 
    1565                 1570                 1575             


Lys Lys  Lys Val Ser Tyr Val  Gln Leu Lys Glu Arg  Cys Arg Ile 
    1580                 1585                 1590             


Glu Pro  His Thr Gly Leu Leu  Leu Leu Ser Val Gln  Lys Arg Ser 
    1595                 1600                 1605             


Met Ser  Phe Gln Gly Ile Arg  Gln Pro Val Thr Val  Thr Glu Leu 
    1610                 1615                 1620             


Val Asp  Ser Gly Ile Leu Arg  Pro Ser Thr Val Asn  Glu Leu Glu 
    1625                 1630                 1635             


Ser Gly  Gln Ile Ser Tyr Asp  Glu Val Gly Glu Arg  Ile Lys Asp 
    1640                 1645                 1650             


Phe Leu  Gln Gly Ser Ser Cys  Ile Ala Gly Ile Tyr  Asn Glu Thr 
    1655                 1660                 1665             


Thr Lys  Gln Lys Leu Gly Ile  Tyr Glu Ala Met Lys  Ile Gly Leu 
    1670                 1675                 1680             


Val Arg  Pro Gly Thr Ala Leu  Glu Leu Leu Glu Ala  Gln Ala Ala 
    1685                 1690                 1695             


Thr Gly  Phe Ile Val Asp Pro  Val Ser Asn Leu Arg  Leu Pro Val 
    1700                 1705                 1710             


Glu Glu  Ala Tyr Lys Arg Gly  Leu Val Gly Ile Glu  Phe Lys Glu 
    1715                 1720                 1725             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Glu Thr  Gly Asn Ile Ile Ser  Leu Phe Gln Ala Met  Asn Lys Glu 
    1745                 1750                 1755             


Leu Ile  Glu Lys Gly His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    1760                 1765                 1770             


Ala Thr  Gly Gly Ile Ile Asp  Pro Lys Glu Ser His  Arg Leu Pro 
    1775                 1780                 1785             


Val Asp  Ile Ala Tyr Lys Arg  Gly Tyr Phe Asn Glu  Glu Leu Ser 
    1790                 1795                 1800             


Glu Ile  Leu Ser Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    1805                 1810                 1815             


Pro Asn  Thr Glu Glu Asn Leu  Thr Tyr Leu Gln Leu  Lys Glu Arg 
    1820                 1825                 1830             


Cys Ile  Lys Asp Glu Glu Thr  Gly Leu Cys Leu Leu  Pro Leu Lys 
    1835                 1840                 1845             


Glu Lys  Lys Lys Gln Val Gln  Thr Ser Gln Lys Asn  Thr Leu Arg 
    1850                 1855                 1860             


Lys Arg  Arg Val Val Ile Val  Asp Pro Glu Thr Asn  Lys Glu Met 
    1865                 1870                 1875             


Ser Val  Gln Glu Ala Tyr Lys  Lys Gly Leu Ile Asp  Tyr Glu Thr 
    1880                 1885                 1890             


Phe Lys  Glu Leu Cys Glu Gln  Glu Cys Glu Trp Glu  Glu Ile Thr 
    1895                 1900                 1905             


Ile Thr  Gly Ser Asp Gly Ser  Thr Arg Val Val Leu  Val Asp Arg 
    1910                 1915                 1920             


Lys Thr  Gly Ser Gln Tyr Asp  Ile Gln Asp Ala Ile  Asp Lys Gly 
    1925                 1930                 1935             


Leu Val  Asp Arg Lys Phe Phe  Asp Gln Tyr Arg Ser  Gly Ser Leu 
    1940                 1945                 1950             


Ser Leu  Thr Gln Phe Ala Asp  Met Ile Ser Leu Lys  Asn Gly Val 
    1955                 1960                 1965             


Gly Thr  Ser Ser Ser Met Gly  Ser Gly Val Ser Asp  Asp Val Phe 
    1970                 1975                 1980             


Ser Ser  Ser Arg His Glu Ser  Val Ser Lys Ile Ser  Thr Ile Ser 
    1985                 1990                 1995             


Ser Val  Arg Asn Leu Thr Ile  Arg Ser Ser Ser Phe  Ser Asp Thr 
    2000                 2005                 2010             


Leu Glu  Glu Ser Ser Pro Ile  Ala Ala Ile Phe Asp  Thr Glu Asn 
    2015                 2020                 2025             


Leu Glu  Lys Ile Ser Ile Thr  Glu Gly Ile Glu Arg  Gly Ile Val 
    2030                 2035                 2040             


Asp Ser  Ile Thr Gly Gln Arg  Leu Leu Glu Ala Gln  Ala Cys Thr 
    2045                 2050                 2055             


Gly Gly  Ile Ile His Pro Thr  Thr Gly Gln Lys Leu  Ser Leu Gln 
    2060                 2065                 2070             


Asp Ala  Val Ser Gln Gly Val  Ile Asp Gln Asp Met  Ala Thr Arg 
    2075                 2080                 2085             


Leu Lys  Pro Ala Gln Lys Ala  Phe Ile Gly Phe Glu  Gly Val Lys 
    2090                 2095                 2100             


Gly Lys  Lys Lys Met Ser Ala  Ala Glu Ala Val Lys  Glu Lys Trp 
    2105                 2110                 2115             


Leu Pro  Tyr Glu Ala Gly Gln  Arg Phe Leu Glu Phe  Gln Tyr Leu 
    2120                 2125                 2130             


Thr Gly  Gly Leu Val Asp Pro  Glu Val His Gly Arg  Ile Ser Thr 
    2135                 2140                 2145             


Glu Glu  Ala Ile Arg Lys Gly  Phe Ile Asp Gly Arg  Ala Ala Gln 
    2150                 2155                 2160             


Arg Leu  Gln Asp Thr Ser Ser  Tyr Ala Lys Ile Leu  Thr Cys Pro 
    2165                 2170                 2175             


Lys Thr  Lys Leu Lys Ile Ser  Tyr Lys Asp Ala Ile  Asn Arg Ser 
    2180                 2185                 2190             


Met Val  Glu Asp Ile Thr Gly  Leu Arg Leu Leu Glu  Ala Ala Ser 
    2195                 2200                 2205             


Val Ser  Ser Lys Gly Leu Pro  Ser Pro Tyr Asn Met  Ser Ser Ala 
    2210                 2215                 2220             


Pro Gly  Ser Arg Ser Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser 
    2225                 2230                 2235             


Arg Ser  Gly Ser Arg Ser Gly  Ser Arg Arg Gly Ser  Phe Asp Ala 
    2240                 2245                 2250             


Thr Gly  Asn Ser Ser Tyr Ser  Tyr Ser Tyr Ser Phe  Ser Ser Ser 
    2255                 2260                 2265             


Ser Ile  Gly His 
    2270         


<210>  21
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  21
ccattggcct gtagattcac ctcccctggg cagggcccca ggacccagga taatatctgt       60

gcctcctgcc cagaaccctc caagcagaca caatggtaag aatggtgcct gtcctgctgt      120

ctctgctgct gcttctgggt cctgctgtcc cccaggagaa ccaagatggt cgttactctc      180

tgacctatat ctacactggg ctgtccaagc atgttgaaga cgtccccgcg tttcaggccc      240

ttggctcact caatgacctc cagttcttta gatacaacag taaagacagg aagtctcagc      300

ccatgggact ctggagacag gtggaaggaa tggaggattg gaagcaggac agccaacttc      360

agaaggccag ggaggacatc tttatggaga ccctgaaaga catcgtggag tattacaacg      420

acagtaacgg gtctcacgta ttgcagggaa ggtttggttg tgagatcgag aataacagaa      480

gcagcggagc attctggaaa tattactatg atggaaagga ctacattgaa ttcaacaaag      540

aaatcccagc ctgggtcccc ttcgacccag cagcccagat aaccaagcag aagtgggagg      600

cagaaccagt ctacgtgcag cgggccaagg cttacctgga ggaggagtgc cctgcgactc      660

tgcggaaata cctgaaatac agcaaaaata tcctggaccg gcaagatcct ccctctgtgg      720

tggtcaccag ccaccaggcc ccaggagaaa agaagaaact gaagtgcctg gcctacgact      780

tctacccagg gaaaattgat gtgcactgga ctcgggccgg cgaggtgcag gagcctgagt      840

tacggggaga tgttcttcac aatggaaatg gcacttacca gtcctgggtg gtggtggcag      900

tgcccccgca ggacacagcc ccctactcct gccacgtgca gcacagcagc ctggcccagc      960

ccctcgtggt gccctgggag gccagctagg aagcaagggt tggaggcaat gtgggatctc     1020

agacccagta gctgcccttc ctgcctgatg tgggagctga accacagaaa tcacagtcaa     1080

tggatccaca aggcctgagg agcagtgtgg ggggacagac aggaggtgga tttggagacc     1140

gaagactggg atgcctgtct tgagtagact tggacccaaa aaatcatctc accttgagcc     1200

cacccccacc ccattgtcta atctgtagaa gctaataaat aatcatccct ccttgcctag     1260

cataaaaaaa aaaaaaaa                                                   1278


<210>  22
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  23
<211>  6483
<212>  DNA
<213>  Homo sapiens

<400>  23
aaatgcgctg gcggggagac cggggttggt ccctggcggg gcagggggcg ggctcaggcc       60

ggaactccag agacgacctc agccaactgc tcctgcgccg ggcggggtcg tcgccgccag      120

cggctccgag cgccggaagg gccaggtctc agggctcctg gagctgcagg cggcgggagg      180

ggctacaaat gcttgactca gtgatgcaga acctttcaga gttagctgga agccacagcc      240

ctgcctcttg atgcagcctg gatccagccg gtgtgaagag gagacccctt ccctcttgtg      300

gggtttggat cctgtgtttc tagcctttgc aaaactctac atcagggata tcctggacat      360

gaaggagtcc cgccaggtgc caggtgtatt tttgtacaat ggacatccaa taaaacaggt      420

agatgtcttg ggaactgtca ttggagtgag agaaagagat gctttctaca gttatggagt      480

ggatgacagc actggagtta taaactgcat ctgctggaaa aagttgaata ctgagtctgt      540

atcagctgct ccaagtgcag caagagagct cagcttaacc tcacaactta agaagctaca      600

agagaccatt gagcagaaaa caaagataga gatcggggac acgatccgag tcagaggcag      660

tatccgcaca tacagagaag agcgagagat tcatgccacc acttactata aagtggacga      720

cccagtgtgg aacattcaaa ttgcaaggat gcttgagctg cccactatct acaggaaagt      780

ttatgaccag ccttttcaca gctcagccct agagaaagaa gaggcactaa gcaatccagg      840

cgccctggac ctccccagtc tcacgagttt gctgagtgaa aaagccaaag aattcctcat      900

ggagaacaga gtgcagagct tttaccagca ggagctggaa atggtggagt ctttgctgtc      960

ccttgccaat cagcctgtga ttcacagtgc ctcctccgac caagtgaatt ttaagaagga     1020

caccacttcc aaggcaattc atagtatatt taagaatgct atacaactgc tgcaggaaaa     1080

aggacttgtt ttccagaaag atgatggttt tgataaccta tactatgtaa ccagagaaga     1140

caaagacctg cacagaaaga tccaccggat cattcagcag gactgccaga aaccaaatca     1200

catggagaag ggctgtcact tcctgcacat cttggcctgt gctcgcctga gcatccgccc     1260

gggcctgagc gaggctgtgc tgcagcaagt tctggagctc ctggaggacc agagtgacat     1320

tgtcagcaca atggagcact actacacagc gttctgagca gagacacgca gaccagctga     1380

ggaggacaaa gataaggtgg cattcacccc caggctctga ctttcagcat catgcagggg     1440

cttatctgtc tggaggcagt tacctcataa taaactataa aatatagtca tcttgggaat     1500

gggatttggc ataaatgttg ttggctccct tctgtccact atgtccttgg tgtacaatga     1560

ctttgatctc agccatgaca caacaagaaa accctccctg ttgagctcct ggctggactg     1620

tgcgttgttc gcagagcaga atggggagga aacagtgttg gcagcttaac tgatgtgtgt     1680

ggttggagtc tcttccatgg caaagggaca ccacagggta gtgaacattc aggaactgag     1740

gggcatatgg cctgatcaca cagttctaag cttttcaaaa cttcaggtta tcagagacct     1800

tcctgtgggc ctctcttgct ggctaagaac cggtttaggg gagtagttct ccctggatga     1860

gtgcttacag tttctgtggc tcagttacca gcagtggggt tgagacctgg gtcgatgctc     1920

tttacaggcc tgcccagaga tgggaataaa cagggatcca cagcgtgact atgtgtttgt     1980

cattttcctt ttatttcctt gggaatcgaa aggtgtccca gtacatttcc ctgcacttac     2040

agaggtgcat gactaaatac attgtccctc gatgcccctg aagatcacgg aggcagtcag     2100

ccaattgcct ggcaggtggt agatgttatt ttcagggttg ccgctgagtg tgcaggatgt     2160

gctgacacca tccagacaaa gactcggtat gtgcccagac aggtgatgga gtcatgcttt     2220

tgctcagaat gacaaggtaa aggaaaaaca tctgaggtat gttgtaggcc tgttctgaca     2280

gcaaaatgac aaatccagcc agcaaaaata aagtgtggag aaagatttgg agttaattac     2340

agtcatttca cagaaggcac tgccttcgtc tgctgcattt gctcttgatg tgataagctc     2400

ttcgtggctc agctggagat cctttaggcc tggagagttg ctcctctctc cgtggaaaca     2460

ggacagtctt tatacgcaga agtccgctgc agctcgatac gtcaggctga gagctagaac     2520

cagtagattg cctcctgtca tagacttttg taatgatgca aacctttgct gatttctaac     2580

agtgattatg tagtggctgc cctgcatctt ctctgtgtac agaagggtcc ctagcataga     2640

gtctgcctgg aatgatgtcc tgggcagttc ttccttgagg tcagcagctg ttccacgttg     2700

aatgcatctg attagtgggg ctgcccagga aggagttcag aatcagaagg taaaaagggc     2760

atacccttgc ctatagcaac tctgctctta ggggtttatc tcaaggagat ggctacacaa     2820

gtgtgaaagg atggttgcac aaggtgttca ttgctgtata atctagaatt ctatattggg     2880

gaaaatacct atagggaaaa agttaattac ggttcttggg cacaatgaaa tactatgcag     2940

ctatgaaaaa aatgatgaaa gcagacagac agtgttgcca tggcacactg tccctagtag     3000

atttagtggg aagtagatag agttatagat ctgtttctat agtataacac cattatctac     3060

agctccctgt gtgtatgtat atatccgtag agagagtgta tatttctgca tggaggtctt     3120

tataaatgta gcacatgtac atatatatat atatacacac acacagtcga ccactccctt     3180

ctcctggaag tactttccgc gtttggcttt caggacacca agctctctgg ttgctccttc     3240

tcaggttcct ttgttcagtg ctctgcctcc ctgaggactc agtcccagac ctcttttcta     3300

tctggcttgc tcactggggt gtctccagca gccacatgga ttataccatc tacatgctgt     3360

ctaacacctc agtttaaacc cagaatgggc ctcttccctg aactgcagac ccctatattc     3420

agtttgctac tgacatctcc acttaggtct ctaatggaca tctcagattt cacaggccca     3480

aagccaggct cccaattact cctgacccca ggcttgctcc tgatagtgac atgaggcagc     3540

caaatgccta ggcagagagg ggagggtccc aaatgaaacc ccacgttcaa gcaaagatca     3600

gcctgaaggc taaaagacca gattgctggt cctggatgaa acccaccacg cagagtggga     3660

acttctgttc ctgtttgccc accctttccc aattgttctt tctgaataac gccttaacca     3720

atcgaatgtt gccttttcca gtaataccta cagcctgccc ctccccccat tctgagccca     3780

taaaaagacc cagactcccc catattaagg ggactttcct gcctttgggt agggggacca     3840

cccccacgtc tcctctctgt tgaaaactgt ttcatcactc aataaaactc ccagctttgc     3900

tcactcttcc actgtcagca cattctcatt cttctttggt gctgggcaag aactcaacca     3960

gtgtggaagc catacttggc ccaggcgggt gaagtgggcg ggccgtctcc tgcagcaggt     4020

agcatggtca agcgaggccc aggtgggccg tcaccagcca gaggtccctg gcttgcaaag     4080

tgaccgagaa aaaaatcctg tgccactcct ttggaaaatg tccctgattc aggaagaggt     4140

agctccatcc agttgctcaa accaaatcca ttggcttctt tctttctatc atacctcaca     4200

tccaatctgt ctgcaagtct tttggctcta ccttcagaat atctccagaa tcttaactgc     4260

ttcaccctcc tccccggcct cctcagtcct ctctgcttcc gccctggccc ctcttgggct     4320

gttcacagca cagcagctgt tgccaccctg ttaatgctcc cactctccta cagccttcgg     4380

tcttgcccca ggtaggagcc tgaggctgca cagaggtcag cacggccccg cttaccctgc     4440

cctcccagcc cagccgcacg ggccttgcac acatgcctcg gcatattcct gccttagggc     4500

tggtgctcct gctatttcct cttcccaggt aaccatgtga agtgcctccc tctgccctct     4560

ttccagcctt tacttgagtg tcaccttctc agtgaggcct gccctcattc ctctttcgct     4620

gtttgcaacc catctcctgt cccccttccc agaactccct ttcctacttc gtttttcttc     4680

acagtacttg atactgccta acacactcca tggtttctta cttgccctgt ttattatttt     4740

cccccaatag acagaatgtt ccatgatggc agaattctct gttttgtttc cttccatgtc     4800

cccagcacct agaacagtgc ctgacgcatc tcctaagcaa tacgaccaat aagtatgtgt     4860

ctggctgcct tccggctgcc agtgtctgcc tctttcctag gggcagtggt tgcgggggtg     4920

ctttctcaca tgtcttagta ggctgtgcag gctggaagtg ctcagaagtc acacccccag     4980

ggagcagcct cagccaacag caccttggct gtaaatgccc cagctccctc gccctcaggt     5040

aagcattgct gaggcacacg ttccatactc ttttccacag ttcctccgtg ggactgagca     5100

ccacccagcc acccacagga gcagctaacc tgataaccac cagcctcacc ctccctgcct     5160

tacttccccg ctccccttta ccacatgctg acctcccaga tgcatttctt gctttccggt     5220

ctctgtctca ggattggctc ctggatgaac acaaactaac actatgttca caaatatatt     5280

tgggaaatgc tggatgaata attatacaca tcagacagat tactagaaat tctcaccaaa     5340

gggatgcaca tgttacctct gcatggtgag atctcaggtg ctttttaccc cacatagcta     5400

tcctttggca tttttataat tagcaagtgc tcactcttcc actgtcagta cattctcatt     5460

cttcttgggc gctggacaag aattcaaccg gtgtgtaagc cagactcggc ccgggcagtc     5520

tcaaactcct gactccttat ataatttcta caaaaattat aaagctattt cccactcccc     5580

accccacatt catgtaacct gaagcatgag taaaccaaga atgaggtagg cctctgtctt     5640

ctaagcaaca tcagaactct aagaacatga gggactctta gaaaactctc tggagctaac     5700

cacagctggg tcactgctca tgtactgaag accagccaga gggttcccct gaaaaggagg     5760

gaaactgagc aaacattctc cagttctctt agtgtgcaca tgtttcagga ggtgtgaacc     5820

ccacatgtag cttgtgtagg caagaagaca aatagtgcta ctgtctggtc aaggatttgt     5880

ttgaagagcc atgattatgc ccatatggta agccaccagt gctccccatc cctgtaagac     5940

acttctttct cattattttc tcctctgatg gtgtgccagg atgctggcca agagaagcca     6000

agtggaaaga aggctgttca gtgacaagga acctaagact tagtgccaag gactgaaacc     6060

aagtaaactt gtaattttcc atgatggaaa catctacact ttctcattag tggcctctac     6120

agcagttgcc ccaaagaagc gtctcattgt ttttttacta catttatgtg aagcatacag     6180

gcaaactcag aaagactgtg ataaggctcg ccagagatgc ctgcacaggt gctgggggaa     6240

aagcaggacc atcctgaagg gagatggtgt ctgtggacaa agaactctgc agtggttctt     6300

atttgcatga tttctgctgg tggaggctgt aaatgtgagc tcaaactccc acataagtga     6360

gttttcattg taatccagaa tgtttttaaa tcaccctact tctattgaac ttgcactatc     6420

atctgttaac ctctactgta tttattaaat aaacctgaat aggtaaatca cagtacagca     6480

aaa                                                                   6483


<210>  24
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Pro Gly Ser Ser Arg Cys Glu Glu Glu Thr Pro Ser Leu Leu 
1               5                   10                  15      


Trp Gly Leu Asp Pro Val Phe Leu Ala Phe Ala Lys Leu Tyr Ile Arg 
            20                  25                  30          


Asp Ile Leu Asp Met Lys Glu Ser Arg Gln Val Pro Gly Val Phe Leu 
        35                  40                  45              


Tyr Asn Gly His Pro Ile Lys Gln Val Asp Val Leu Gly Thr Val Ile 
    50                  55                  60                  


Gly Val Arg Glu Arg Asp Ala Phe Tyr Ser Tyr Gly Val Asp Asp Ser 
65                  70                  75                  80  


Thr Gly Val Ile Asn Cys Ile Cys Trp Lys Lys Leu Asn Thr Glu Ser 
                85                  90                  95      


Val Ser Ala Ala Pro Ser Ala Ala Arg Glu Leu Ser Leu Thr Ser Gln 
            100                 105                 110         


Leu Lys Lys Leu Gln Glu Thr Ile Glu Gln Lys Thr Lys Ile Glu Ile 
        115                 120                 125             


Gly Asp Thr Ile Arg Val Arg Gly Ser Ile Arg Thr Tyr Arg Glu Glu 
    130                 135                 140                 


Arg Glu Ile His Ala Thr Thr Tyr Tyr Lys Val Asp Asp Pro Val Trp 
145                 150                 155                 160 


Asn Ile Gln Ile Ala Arg Met Leu Glu Leu Pro Thr Ile Tyr Arg Lys 
                165                 170                 175     


Val Tyr Asp Gln Pro Phe His Ser Ser Ala Leu Glu Lys Glu Glu Ala 
            180                 185                 190         


Leu Ser Asn Pro Gly Ala Leu Asp Leu Pro Ser Leu Thr Ser Leu Leu 
        195                 200                 205             


Ser Glu Lys Ala Lys Glu Phe Leu Met Glu Asn Arg Val Gln Ser Phe 
    210                 215                 220                 


Tyr Gln Gln Glu Leu Glu Met Val Glu Ser Leu Leu Ser Leu Ala Asn 
225                 230                 235                 240 


Gln Pro Val Ile His Ser Ala Ser Ser Asp Gln Val Asn Phe Lys Lys 
                245                 250                 255     


Asp Thr Thr Ser Lys Ala Ile His Ser Ile Phe Lys Asn Ala Ile Gln 
            260                 265                 270         


Leu Leu Gln Glu Lys Gly Leu Val Phe Gln Lys Asp Asp Gly Phe Asp 
        275                 280                 285             


Asn Leu Tyr Tyr Val Thr Arg Glu Asp Lys Asp Leu His Arg Lys Ile 
    290                 295                 300                 


His Arg Ile Ile Gln Gln Asp Cys Gln Lys Pro Asn His Met Glu Lys 
305                 310                 315                 320 


Gly Cys His Phe Leu His Ile Leu Ala Cys Ala Arg Leu Ser Ile Arg 
                325                 330                 335     


Pro Gly Leu Ser Glu Ala Val Leu Gln Gln Val Leu Glu Leu Leu Glu 
            340                 345                 350         


Asp Gln Ser Asp Ile Val Ser Thr Met Glu His Tyr Tyr Thr Ala Phe 
        355                 360                 365             


<210>  25
<211>  8795
<212>  DNA
<213>  Homo sapiens

<400>  25
gcggccgcac tagtaccccg gagcccatgg gcgcgccgag ccgggcgcgg gggcgctgaa       60

cggcggagcg ggagcggccg gaggagccat ggactgcagc ctcgtgcgga cgctcgtgca      120

cagatactgt gcaggagaag agaattgggt ggacagcagg accatctacg tgggacacag      180

ggagccacct ccgggcgcag aggcctacat cccacagaga tacccagaca acaggatcgt      240

ctcgtccaag tacacatttt ggaactttat acccaagaat ttatttgaac aattcagaag      300

agtagccaac ttttatttcc ttatcatatt tctggtgcag ttgattattg atacacccac      360

aagtccagtg acaagcggac ttccactctt ctttgtcatt actgtgacgg ctatcaaaca      420

gggttatgaa gactggcttc gacataaagc agacaatgcc atgaaccagt gtcctgttca      480

tttcattcag cacggcaagc tcgttcggaa acaaagtcga aagctgcgag ttggggacat      540

tgtcatggtt aaggaggacg agacctttcc ctgcgacttg atcttccttt ccagcaaccg      600

gggagatggg acgtgccacg tcaccaccgc cagcttggat ggagaatcca gccataaaac      660

gcattacgcg gtccaggaca ccaaaggctt ccacacagag gaggatatcg gcggacttca      720

cgccaccatc gagtgtgagc agccccagcc cgacctctac aagttcgtgg gtcgcatcaa      780

cgtttacagt gacctgaatg accccgtggt gaggccctta ggatcggaaa acctgctgct      840

tagaggagct acactgaaga acactgagaa aatctttggt gtggctattt acacgggaat      900

ggaaaccaag atggcattaa attatcaatc aaaatctcag aagcgatctg ccgtggaaaa      960

atcgatgaat gcgttcctca ttgtgtatct ctgcattctg atcagcaaag ccctgataaa     1020

cactgtgctg aaatacatgt ggcagagtga gccctttcgg gatgagccgt ggtataatca     1080

gaaaacggag tcggaaaggc agaggaatct gttcctcaag gcattcacgg acttcctggc     1140

cttcatggtc ctctttaact acatcatccc tgtgtccatg tacgtcacgg tcgagatgca     1200

gaagttcctc ggctcttact tcatcacctg ggacgaagac atgtttgacg aggagactgg     1260

cgaggggcct ctggtgaaca cgtcggacct caatgaagag ctgggacagg tggagtacat     1320

cttcacagac aagaccggca ccctcacgga aaacaacatg gagttcaagg agtgctgcat     1380

cgaaggccat gtctacgtgc cccacgtcat ctgcaacggg caggtcctcc cagagtcgtc     1440

aggaatcgac atgattgact cgtcccccag cgtcaacggg agggagcgcg aggagctgtt     1500

tttccgggcc ctctgtctct gccacaccgt ccaggtgaaa gacgatgaca gcgtagacgg     1560

ccccaggaaa tcgccggacg gggggaaatc ctgtgtgtac atctcatcct cgcccgacga     1620

ggtggcgctg gtcgaaggtg tccagagact tggctttacc tacctaaggc tgaaggacaa     1680

ttacatggag atattaaaca gggagaacca catcgaaagg tttgaattgc tggaaatttt     1740

gagttttgac tcagtcagaa ggagaatgag tgtaattgta aaatctgcta caggagaaat     1800

ttatctgttt tgcaaaggag cagattcttc gatattcccc cgagtgatag aaggcaaagt     1860

tgaccagatc cgagccagag tggagcgtaa cgcagtggag gggctccgaa ctttgtgtgt     1920

tgcttataaa aggctgatcc aagaagaata tgaaggcatt tgtaagctgc tgcaggctgc     1980

caaagtggcc cttcaagatc gagagaaaaa gttagcagaa gcctatgagc aaatagagaa     2040

agatcttact ctgcttggtg ctacagctgt tgaggaccgg ctgcaggaga aagctgcaga     2100

caccatcgag gccctgcaga aggccgggat caaagtctgg gttctcacgg gagacaagat     2160

ggagacggcc gcggccacgt gctacgcctg caagctcttc cgcaggaaca cgcagctgct     2220

ggagctgacc accaagagga tcgaggagca gagcctgcac gacgtcctgt tcgagctgag     2280

caagacggtc ctgcgccaca gcgggagcct gaccagagac aacctgtccg gactttcagc     2340

agatatgcag gactacggtt taattatcga cggagctgca ctgtctctga taatgaagcc     2400

tcgagaagac gggagttccg gcaactacag ggagctcttc ctggaaatct gccggagctg     2460

cagcgcggtg ctctgctgcc gcatggcgcc cttgcagaag gctcagattg ttaaattaat     2520

caaattttca aaagagcacc caatcacgtt agcaattggc gatggtgcaa atgatgtcag     2580

catgattctg gaagcgcacg tgggcatagg tgtcatcggc aaggaaggcc gccaggctgc     2640

caggaacagc gactatgcaa tcccaaagtt taagcatttg aagaagatgc tgcttgttca     2700

cgggcatttt tattacatta ggatctctga gctcgtgcag tacttcttct ataagaacgt     2760

ctgcttcatc ttccctcagt ttttatacca gttcttctgt gggttttcac aacagacttt     2820

gtacgacacc gcgtatctga ccctctacaa catcagcttc acctccctcc ccatcctcct     2880

gtacagcctc atggagcagc atgttggcat tgacgtgctc aagagagacc cgaccctgta     2940

cagggacgtc gccaagaatg ccctgctgcg ctggcgcgtg ttcatctact ggacgctcct     3000

gggactgttt gacgcactgg tgttcttctt tggtgcttat ttcgtgtttg aaaatacaac     3060

tgtgacaagc aacgggcaga tatttggaaa ctggacgttt ggaacgctgg tattcaccgt     3120

gatggtgttc acagttacac taaagcttgc attggacaca cactactgga cttggatcaa     3180

ccattttgtc atctgggggt cgctgctgtt ctacgttgtc ttttcgcttc tctggggagg     3240

agtgatctgg ccgttcctca actaccagag gatgtactac gtgttcatcc agatgctgtc     3300

cagcgggccc gcctggctgg ccatcgtgct gctggtgacc atcagcctcc ttcccgacgt     3360

cctcaagaaa gtcctgtgcc ggcagctgtg gccaacagca acagagagag tccagactaa     3420

gagccagtgc ctttctgtcg agcagtcaac catctttatg ctttctcaga cttccagcag     3480

cctgagtttc tgatggaaca agagcccagg ctaccagagc acctgtccct cggccgcctg     3540

gtacagctcc cactctcagc aggtgacact cgcggcctgg aaggagaagg tgtccacgga     3600

gcccccaccc atcctcggcg gttcccatca ccactgcagt tccatcccaa gtcacagctg     3660

ccctaggtcc cgtgtgggaa tgctcgtgtg atggatggtc ctaagcctgt ggagactgtg     3720

cacgtgcctc ttcctggccc ccagcaggca aggagggggg tcacaggcct tgccctcgag     3780

catggcaccc tggccgcctg gacccagcac tgtggttgtt gagccacacc agtggcctct     3840

gggcattcgg ctcaacgcag gagggacatt ctgctggccc accctgcgcg ctgtcatgca     3900

gaggccattc ccccaggcct gtgtcttcac ccacctgcca tcattggcct ttgctgtcac     3960

tgggagagaa gagccgtcca gggacccatg gtggcccaca tgtggatgcc acatgctgct     4020

gtttcctgct tgcccggcca ccacccatgc cctccatagg gtgaggtgga gccatggtgg     4080

tgcgtccttt actcaacaac cctccaatcc ggatgctgtg ggaagggccg ggtcactcgg     4140

ataccatcat ccctgcggat gcaccgccgt accctgctca tctgggagtg gtttccctgc     4200

ggttacgtcc aagcccgcct gccctgtgtg ttggggctgg ctgagtttcg gtctccccat     4260

caccggccgc ctcgtggaga aggcagtgcc acgtgggagg acaaggccac gccggcagct     4320

tccagccctg ccgcagaagt gccaggatgt ccatcagcca ctcgccaggg cacggagccg     4380

tcagtccact gttacgggag aatgttgatt tcgcgggtgc gagggccggg agacagatac     4440

ttggctgtga tgagcagaca tcctctgtcc ccgtggaggg gtcaacacca aggtggtgtt     4500

cgtgcaccag aacctgtctc gggctgacgg gggtggcaca caggacacgg gtggatccca     4560

acaggcagca ccgcacctct gcccgcctcc cgcactgcag ctccgcccgc cgggctctgc     4620

gtccccacgt cccctcgtcc catccccacg tcccctcatc ccgtcacctc gtccccacat     4680

ccccttgccc cgtcacctcg tcctcatgtc cccttgtcct gtcacctcgt ccccacgtcc     4740

cctcgtctcc tcatccccac gtcctctcgt ccccttgtcc cgtccccaca taccctcgtc     4800

cccatgtccc cacgcagggc tctccttcgt cttaggatct gtccagcgct gctctgggtg     4860

ggttagcaac cccagggctg ctgtgatagg aagtccctgt tgttctccgt actggcattt     4920

ctatttctag aaataatatt tgacatagcc ttaatggtcc ttaaagaaga catttcagtg     4980

tgagattcag acttcagacg ctgaaactgc tgcctttcag gaaagcacca ccaacgctgg     5040

aggaggagcc ggccctcacg cccgccccgc gccacgctgt ggaacggggc tccggcaagt     5100

gaaacccaga gggtgtttcc gaggtgctcg acagtaggta tttttggaag ctcagatttc     5160

accatttgat tgtataatct tttacctata aaatatttat ttgaagtaga gggtaaatca     5220

gcggtaagaa cagtgaacac agtggttggg ataaaataag gtgacaaaca tcacaccaaa     5280

gatgagggta gcgagcaact ggcttgagca gacagaacgg ggaagactcc actctgtccc     5340

gaggggccag ccgcaggcgt ccccagggcc accctgccct gaggtccttg tgtggccgcc     5400

ctggcttggc agccctgccc acgctgcccc cgcaaacaat ggtgtgtgcg tttttacagc     5460

cctttttagg aacccaatat gggcataaat gtaacacctg tagcgggggc agattctctg     5520

tatgttcagt taacaaatta tttgtaatgt atttttttag aaatcttaaa attgcctttg     5580

cactgaagta ttttcatagc tgtttatatc tcttttattc atttatttaa catactgtct     5640

aattttaaaa ataggttttt aaagctttca tttttaagtt tatgaaattt tggccacttt     5700

acatttagat tctggtgaga gttttgactg aatgttccaa tctctgatga atgcgaattt     5760

tcagatttga ttttattctc tacacacacc tcttcttttc ttggtatttc tggtggcagt     5820

gattagttga acagcacatt taaggcacga taatttgcta cactttttct ttacaatttg     5880

ttgcaatttc atctgctttc tatgtttcat tgttaattgc catccttcag ccttaaaaat     5940

agaagattct cacgtgaagg tttagtaagt tgggtcccag ctctgcctgt gtggagatag     6000

tcaccatgta cctctgacaa caagttttag tgtgaaagtc actaaacttt tacacactcc     6060

caaacgtctt tttaaaaatt gcttgggaaa ttattaaatg aatgtgcctg atgatttgaa     6120

atagacaagg ggcacgagat aaaaaagaaa aggatgagaa gatcctcagt gaatgacgtt     6180

gcagggtctt catgcaattt tccacctcgc agtagttagt atttacttgc cttaaactaa     6240

ctttgaagca agtaatgtca actttgagca ctttgttgag ttttgaaaaa tcttatttgt     6300

tgctgcacag gttaataaat tatcaatttg taattcagca tgttggtcag agacacggtc     6360

actgattcac acccagtccc tgccacagac cgtctcagac acgcacagtg ggcctgctgc     6420

atgattcaca cccagtccct gccacagacc gtctcagaca cgcacagtgg gcctgctgca     6480

tgattcacac ccagtccctg ccacagaccg tctcagacac gcacagtggg cctgctgcat     6540

gcgtgttacc tggcttttgg ctccacgctc actcatagcc atgtccacat gggggcttgc     6600

acacaggatc actcacatat gtacatgtac ccaccacaaa cgtgcaagct cctgcacaca     6660

tgcatgcaca caaacgtgta cacaagtgtg agctcctaca cgcatacaca cacacacgtg     6720

tacatgcacc aaagcatgtg tgacctacag acatgcagaa catgcacgtg tacacatacc     6780

acagacacgc gtgtgcatgc tcctacacaa tacatatgca catatcatga acagcgtaag     6840

ttcctacaca cggacgtgtg atacacacat gcatgtacag gtaagcacac atgtacaagc     6900

tcctacaggc ttgctctcac acacgtgtat gcacagcaga gagacgtatg agcttctact     6960

gcacacatgc acacacacac gcacacgtac attcactaca aacgtgcagc ctcctgcaca     7020

cgtgcacatt catgtgtaca ccacaaatga gttcccagac gtgtaaacac acgtgcacac     7080

atcgtacaca tgtgagctcc cacacgtaca cacagatgca catggacaca ccccaaacac     7140

gcacaggctc ctacacacat gcacacacgt gtacaccaca aacgagctcc cagacatgta     7200

aacacacgtc tcccacacgt gagctcccac acgtacacat gcacatgtac gcaccacaaa     7260

cacatgcgca ggctcctgca ggcgtgaata cacacatgca cacacatata cacacatgtg     7320

ccacaaacaa gtgcacactg tcctggtgtc ctgcactgca tcctgcctcc ttgctgaggg     7380

gcccctgtga gaggcctctg gatgggcatg ggaagatggg ctccctggcc cccagcccat     7440

gcctccctgg gatgaagagt ccccctcctg gcagaatgtc tgggctttgc agagcaggcc     7500

ccgggggtga agtcgcagct tcacttacac cagctgctct gtgagcaagg cttggtgccc     7560

tggacaaggc ccttcccctt tagggaggtc cagcctcgca agctgaaacc tcccctcggc     7620

tcagccctat accaggcggc cacagcagga ctggccacac ccacgccgca cctcatccgt     7680

gcacgcgtcg gagcacggcc agccttccgc cacgagccag ctgggaaggg ccgcggccgc     7740

ctaaagcccc agtcaaccca gcctgtgtct gagcagacag ggcgaacaag caggccacac     7800

cgtctcgagg gaggaggcca gatgcggcca gcgtctccaa cagggtgacc atccgctcgg     7860

cttgctgagc gtttaaacaa atgtttagac aggctgtggg gactcccctg agttgagcct     7920

tggccagggg tccggtgctg tcgcgggaaa cctccagcct tgttcttcaa accactcagc     7980

tcatgtgttt tgcactgact agtactgaat aatacaacca ctcttattta atgttagtat     8040

tatttatttg acaactcagt gtctaacagc ttgatatgca ggtccttgca tcctacattt     8100

ctttaggaag ttacccattt gtaactttaa aaacaggaaa aatatcagtt ggcaaatgca     8160

atcttttttt tttttaagct aaaggtgggt gaactggaat gaaaatcttt ctgatgttgt     8220

gtctataagc agccttgatg ggatatgtta gaagtgtcat gaaagtgtga ttctactttt     8280

gcagaaaaat ctaaagatca atttatatag ctttattttt tactttatca aagtatacag     8340

aattttaata tgcatatatt gtgtctgact taaaattata atgtctgcgt caccatttaa     8400

aatgtctgtt cattatgtaa tgtaataaaa gaaggtcttc aaaaatgtat ttaacatgaa     8460

tggtatccat agttgtcatc atcataaata ctggagttta tttttaaatt attaaacata     8520

gtaggtgcat taacataaat cagtctccac acagtaacat ttaactgata attcattaat     8580

cagctttgaa aaattaaatt gttaattaaa ccaatctaac atttcagtaa agtttatttt     8640

gtatgcttct gtttttaact tttatttctg tagataaact gactggataa tattatattg     8700

gacttttctc tagattatct aagcaggaga cctgaatctg cttgcaataa agaataaaag     8760

tctgcttcag tttctttata aagaaactca cacaa                                8795


<210>  26
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Cys Ser Leu Val Arg Thr Leu Val His Arg Tyr Cys Ala Gly 
1               5                   10                  15      


Glu Glu Asn Trp Val Asp Ser Arg Thr Ile Tyr Val Gly His Arg Glu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Ala Tyr Ile Pro Gln Arg Tyr Pro Asp Asn 
        35                  40                  45              


Arg Ile Val Ser Ser Lys Tyr Thr Phe Trp Asn Phe Ile Pro Lys Asn 
    50                  55                  60                  


Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile 
65                  70                  75                  80  


Phe Leu Val Gln Leu Ile Ile Asp Thr Pro Thr Ser Pro Val Thr Ser 
                85                  90                  95      


Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly 
            100                 105                 110         


Tyr Glu Asp Trp Leu Arg His Lys Ala Asp Asn Ala Met Asn Gln Cys 
        115                 120                 125             


Pro Val His Phe Ile Gln His Gly Lys Leu Val Arg Lys Gln Ser Arg 
    130                 135                 140                 


Lys Leu Arg Val Gly Asp Ile Val Met Val Lys Glu Asp Glu Thr Phe 
145                 150                 155                 160 


Pro Cys Asp Leu Ile Phe Leu Ser Ser Asn Arg Gly Asp Gly Thr Cys 
                165                 170                 175     


His Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Ser His Lys Thr His 
            180                 185                 190         


Tyr Ala Val Gln Asp Thr Lys Gly Phe His Thr Glu Glu Asp Ile Gly 
        195                 200                 205             


Gly Leu His Ala Thr Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr 
    210                 215                 220                 


Lys Phe Val Gly Arg Ile Asn Val Tyr Ser Asp Leu Asn Asp Pro Val 
225                 230                 235                 240 


Val Arg Pro Leu Gly Ser Glu Asn Leu Leu Leu Arg Gly Ala Thr Leu 
                245                 250                 255     


Lys Asn Thr Glu Lys Ile Phe Gly Val Ala Ile Tyr Thr Gly Met Glu 
            260                 265                 270         


Thr Lys Met Ala Leu Asn Tyr Gln Ser Lys Ser Gln Lys Arg Ser Ala 
        275                 280                 285             


Val Glu Lys Ser Met Asn Ala Phe Leu Ile Val Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Ile Ser Lys Ala Leu Ile Asn Thr Val Leu Lys Tyr Met Trp Gln Ser 
305                 310                 315                 320 


Glu Pro Phe Arg Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu Ser Glu 
                325                 330                 335     


Arg Gln Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe 
            340                 345                 350         


Met Val Leu Phe Asn Tyr Ile Ile Pro Val Ser Met Tyr Val Thr Val 
        355                 360                 365             


Glu Met Gln Lys Phe Leu Gly Ser Tyr Phe Ile Thr Trp Asp Glu Asp 
    370                 375                 380                 


Met Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp 
385                 390                 395                 400 


Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Ile Phe Thr Asp Lys Thr 
                405                 410                 415     


Gly Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys Ile Glu 
            420                 425                 430         


Gly His Val Tyr Val Pro His Val Ile Cys Asn Gly Gln Val Leu Pro 
        435                 440                 445             


Glu Ser Ser Gly Ile Asp Met Ile Asp Ser Ser Pro Ser Val Asn Gly 
    450                 455                 460                 


Arg Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr 
465                 470                 475                 480 


Val Gln Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro 
                485                 490                 495     


Asp Gly Gly Lys Ser Cys Val Tyr Ile Ser Ser Ser Pro Asp Glu Val 
            500                 505                 510         


Ala Leu Val Glu Gly Val Gln Arg Leu Gly Phe Thr Tyr Leu Arg Leu 
        515                 520                 525             


Lys Asp Asn Tyr Met Glu Ile Leu Asn Arg Glu Asn His Ile Glu Arg 
    530                 535                 540                 


Phe Glu Leu Leu Glu Ile Leu Ser Phe Asp Ser Val Arg Arg Arg Met 
545                 550                 555                 560 


Ser Val Ile Val Lys Ser Ala Thr Gly Glu Ile Tyr Leu Phe Cys Lys 
                565                 570                 575     


Gly Ala Asp Ser Ser Ile Phe Pro Arg Val Ile Glu Gly Lys Val Asp 
            580                 585                 590         


Gln Ile Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr 
        595                 600                 605             


Leu Cys Val Ala Tyr Lys Arg Leu Ile Gln Glu Glu Tyr Glu Gly Ile 
    610                 615                 620                 


Cys Lys Leu Leu Gln Ala Ala Lys Val Ala Leu Gln Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Leu Ala Glu Ala Tyr Glu Gln Ile Glu Lys Asp Leu Thr Leu Leu 
                645                 650                 655     


Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Glu Lys Ala Ala Asp Thr 
            660                 665                 670         


Ile Glu Ala Leu Gln Lys Ala Gly Ile Lys Val Trp Val Leu Thr Gly 
        675                 680                 685             


Asp Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe 
    690                 695                 700                 


Arg Arg Asn Thr Gln Leu Leu Glu Leu Thr Thr Lys Arg Ile Glu Glu 
705                 710                 715                 720 


Gln Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg 
                725                 730                 735     


His Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp 
            740                 745                 750         


Met Gln Asp Tyr Gly Leu Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile 
        755                 760                 765             


Met Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe 
    770                 775                 780                 


Leu Glu Ile Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala 
785                 790                 795                 800 


Pro Leu Gln Lys Ala Gln Ile Val Lys Leu Ile Lys Phe Ser Lys Glu 
                805                 810                 815     


His Pro Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met 
            820                 825                 830         


Ile Leu Glu Ala His Val Gly Ile Gly Val Ile Gly Lys Glu Gly Arg 
        835                 840                 845             


Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Pro Lys Phe Lys His Leu 
    850                 855                 860                 


Lys Lys Met Leu Leu Val His Gly His Phe Tyr Tyr Ile Arg Ile Ser 
865                 870                 875                 880 


Glu Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Phe Pro 
                885                 890                 895     


Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Thr Leu Tyr 
            900                 905                 910         


Asp Thr Ala Tyr Leu Thr Leu Tyr Asn Ile Ser Phe Thr Ser Leu Pro 
        915                 920                 925             


Ile Leu Leu Tyr Ser Leu Met Glu Gln His Val Gly Ile Asp Val Leu 
    930                 935                 940                 


Lys Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu 
945                 950                 955                 960 


Arg Trp Arg Val Phe Ile Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala 
                965                 970                 975     


Leu Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val 
            980                 985                 990         


Thr Ser Asn Gly Gln Ile Phe Gly  Asn Trp Thr Phe Gly  Thr Leu Val 
        995                 1000                 1005             


Phe Thr  Val Met Val Phe Thr  Val Thr Leu Lys Leu  Ala Leu Asp 
    1010                 1015                 1020             


Thr His  Tyr Trp Thr Trp Ile  Asn His Phe Val Ile  Trp Gly Ser 
    1025                 1030                 1035             


Leu Leu  Phe Tyr Val Val Phe  Ser Leu Leu Trp Gly  Gly Val Ile 
    1040                 1045                 1050             


Trp Pro  Phe Leu Asn Tyr Gln  Arg Met Tyr Tyr Val  Phe Ile Gln 
    1055                 1060                 1065             


Met Leu  Ser Ser Gly Pro Ala  Trp Leu Ala Ile Val  Leu Leu Val 
    1070                 1075                 1080             


Thr Ile  Ser Leu Leu Pro Asp  Val Leu Lys Lys Val  Leu Cys Arg 
    1085                 1090                 1095             


Gln Leu  Trp Pro Thr Ala Thr  Glu Arg Val Gln Thr  Lys Ser Gln 
    1100                 1105                 1110             


Cys Leu  Ser Val Glu Gln Ser  Thr Ile Phe Met Leu  Ser Gln Thr 
    1115                 1120                 1125             


Ser Ser  Ser Leu Ser Phe 
    1130                 


<210>  27
<211>  4575
<212>  DNA
<213>  Homo sapiens

<400>  27
tttccgcagt taggggctgc tatttcaacg cagggagata aaaagaaaaa aacacttgct       60

cttctacccc gctaaaaaca ctcatcctag ggagcacgcc agcatttgca gcgttcgggg      120

cagggccact cggcctgcgg ccgttgcact ggctggaagc tggcaggcga tcacggttga      180

ttggctcggg tgcggtccaa gggcagcaac gccttcggcg ggccgcctag ggtgattggc      240

tgctgcagcc caccccctag ccggtttggt gggcggcgaa gcctggattg gtggagctaa      300

gagctggctc agtttcagcg ctggctcttc gtgcatggca gagatggcga ctgcgactcg      360

gctgctgggg tggcgtgtgg cgagctggag gctgcggccg ccgcttgccg gcttcgtttc      420

ccagcgggcc cactcgcttt tgcccgtgga cgatgcaatc aatgggctaa gcgaggagca      480

gaggcaggaa ttttggaagc agctggggaa cctgggcgta ttgggcatca cagcccctgt      540

tcagtatggc ggctccggcc tgggctacct ggagcatgtg ctggtgatgg aggagatatc      600

ccgagcttcc ggagcagtgg ggctcagtta cggtgcccac tccaacctct gcatcaacca      660

gcttgtacgc aatgggaatg aggcccagaa agagaagtat ctcccgaagc tgatcagtgg      720

tgagtacatc ggagccctgg ccatgagtga gcccaatgca ggctctgatg ttgtctctat      780

gaagctcaaa gcggaaaaga aaggaaatca ctacatcctg aatggcaaca agttctggat      840

cactaatggc cctgatgctg acgtcctgat tgtctatgcc aagacagatc tggctgctgt      900

gccagcttct cggggcatca cagccttcat tgtggagaag ggtatgcctg gctttagcac      960

ctctaagaag ctggacaagc tggggatgag gggctctaac acctgtgagc taatctttga     1020

agactgcaag attcctgctg ccaacatcct gggccatgag aataagggtg tctacgtgct     1080

gatgagtggg ctggacctgg agcggctggt gctggccggg gggcctcttg ggctcatgca     1140

agcggtcctg gaccacacca ttccctacct gcacgtgagg gaagcctttg gccagaagat     1200

cggccacttc cagttgatgc aggggaagat ggctgacatg tacacccgcc tcatggcgtg     1260

tcggcagtat gtctacaatg tcgccaaggc ctgcgatgag ggccattgca ctgctaagga     1320

ctgtgcaggt gtgattcttt actcagctga gtgtgccaca caggtagccc tggacggcat     1380

tcagtgtttt ggtggcaatg gctacatcaa tgactttccc atgggccgct ttcttcgaga     1440

tgccaagctg tatgagatag gggctgggac cagcgaggtg aggcggctgg tcatcggcag     1500

agccttcaat gcagactttc actagtcctg agacccttcg cccccttttc ctgcacctag     1560

tggcctttct tgggaagtag agatgtggcg gctttcccac cctgcccaca gcaggccctc     1620

ctgcccagct gctcttgtca gccctctggc ctctggatga ggttgagttc tccacaacag     1680

ctcccaagca tcatgggcct cgcagccggg cctgtgccac ggctagtgtt gtgtgattta     1740

aaatggactc agcaggaagc atattgtctg gggattgttg ggacaggttt tggtgactct     1800

gtgcccttgc tctctaactt ctgagcccac ctcccagggt aggcacctgg gggcatgcag     1860

gtgcccacct cccagggtag gcacctgggg gcatgcaggt acccacctct ttctcttggg     1920

tgaggctctg gcaaggagat ctctctgctc aagcacagca gaatcatggc ccctctccat     1980

gaattggaac ttggtacagg ttaagtatcc ctaatcctga aatctgaaac acttgtggtt     2040

ccaagcattt tggataaggc aaattcaact ttcagtctct tttctggggg aaaaaaataa     2100

taaacctagc ctagccaggc gtggtggctc atgcttgtaa tcccagcact tcaggaggct     2160

gagatgggtg gatcacctga ggtcaggagt tcaagaccag cctggccaac atgtggaaac     2220

ctcgcctcaa ctaaaaatag aaaaaaatta gttgggcatg gtggtgggca cctgtaatcc     2280

cagctacttc aggaggctga ggcaggagaa ttacttgaac ccaggaggcg gacgttgcag     2340

tgagccgagc ttgtgccatt gcactccagc ctgggcgaca agagcaaaac tcttcaaaaa     2400

acaaaacaaa acaaaaaaac cctggccctt gtttcttcca gtttctagag gtatcagctc     2460

ctagcagctt atgaacacat atgcttgctt ggccaggcaa ggtggtgtgt gcctgtaatc     2520

ccagcacttt gggaggccaa ggcaggtgga tcacttgcag tcaggagttc aagaccagcc     2580

tgtccaacgt ggtgaaaccc catctctact aaaaatacaa aaattagcca ggggtggtgg     2640

tgcacgtctg taatcccagc tactcaggag gctgaggcag gagaatcact tgaacccggg     2700

aggtggaggt tgcaatgagc caatatgaca ccgctgcagt ccagcctggg ccatagagtg     2760

agactctgtc tcaaaaaagg aaagaaaaat aggctgggca cagtgactca tgcctgtaat     2820

cccaacactt tgggaggccg aggcaggtgg atcacgaggt caggagttca agaccagcct     2880

ggccaagatg gtaaaacctc gtctctacta aaaatacaaa aattagccag gtgtggtggc     2940

aggctcctgt aatcccagct actcaggagg ctgaggcaga gaattgcttg aacccgggag     3000

gcagagtttg cagtgagcca agatcacacc actgcactcc agcttggacg acagagcgag     3060

actctgtctc aaaaaataat aggccaggca tggtggctca acgtctgtaa tcccagcact     3120

ttgggaggcc gaggcgggca gatcacaagg tcaggagttc gagaccagcc tgacgaccaa     3180

catggtgaaa cctcgtctct actaaaaata caaaaattag ccaggcctgg tggcacgcgc     3240

ctgtaatccc agttacacag aagactgagg caggagaatc gcttgaacgc aggaggcaga     3300

ggttgcagga gctgagatcg cgccattgca ctccagcctg ggcaacagag tgagactctg     3360

tctcaaaaaa taataataaa ataaatgaac acacatgctg ctgagtccgc agggggggca     3420

gagcagagga cagcgtgctt ttgtgtactg ttggaagact ggctcctcct gtacagcacc     3480

tctgagccct tgtgcaccgc cctgccacgg gcaccatcca gtcctggccg tgtgaccacc     3540

cacagctgac tgggcagcag gcacaggccc tacccgagca ggccggagtt ggctcgcatg     3600

actccagctg aggctgcctg tgtacatttc tccagatacc ctatggctaa ttttgttata     3660

actgcacagt ggctgctgcc attttgtatt aaatatattg tgaaacaaac ctatctgggg     3720

agaagcaatc tacttgccgc tgcttcctgt ctggatccag cttgtgtcct tggagagtgg     3780

ctggcccagg tcctattcct gtcctccagc ccgttctttc atgagggaca ggaaggtaaa     3840

atcagccctt aggagagagg tctcagcctc cctttcccag atctcccagt gagttttaaa     3900

ggaagcaggg agcccagagt gctaagttct tacagccaga aggaagctta tagatttctg     3960

aaaaccgccc ctttgttttt aaaaagatca acacaatttg actttctcaa ggtcaaaacg     4020

aactagaatc cagatctgct catggcaaaa atgggggtgt tctgagaatt ccagctttgg     4080

gccgcactgt acagcagtct ggatagagtg tgatctgaga agggaatggg tctgggttgt     4140

tccacccctt ccgagttcca aaaagaggga actggttttc ttggttctca gcccagcagc     4200

acctatcctg gctcttggtc ctggcctgca gccaagtgct gttcctagcc tgaggcttga     4260

gacaggtggg gttggctcct caccaacccc agttccgtcc catcctgagg gcaagatcct     4320

gggctcatag gcagtccctt tcacttcctt gtcttgctcc ctgctatgtt ggagatgaat     4380

gtgactaaaa gggccatctt gctggcttaa tgtgtggctg gagagaccag cctggagaca     4440

atgtggcaaa atggggcgct tcatccagtc tgtctaagcc ctgtcgactt ggggaggtga     4500

tttctttcct ggttctatat gtgaagcaaa ataaatgttt taaaattaaa agcaaaaaaa     4560

acaaaatgaa ccatg                                                      4575


<210>  28
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Glu Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala 
1               5                   10                  15      


Ser Trp Arg Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala 
            20                  25                  30          


His Ser Leu Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu 
        35                  40                  45              


Gln Arg Gln Glu Phe Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly 
    50                  55                  60                  


Ile Thr Ala Pro Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu 
65                  70                  75                  80  


His Val Leu Val Met Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly 
                85                  90                  95      


Leu Ser Tyr Gly Ala His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg 
            100                 105                 110         


Asn Gly Asn Glu Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser 
        115                 120                 125             


Gly Glu Tyr Ile Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser 
    130                 135                 140                 


Asp Val Val Ser Met Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr 
145                 150                 155                 160 


Ile Leu Asn Gly Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp 
                165                 170                 175     


Val Leu Ile Val Tyr Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser 
            180                 185                 190         


Arg Gly Ile Thr Ala Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser 
        195                 200                 205             


Thr Ser Lys Lys Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys 
    210                 215                 220                 


Glu Leu Ile Phe Glu Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly 
225                 230                 235                 240 


His Glu Asn Lys Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu 
                245                 250                 255     


Arg Leu Val Leu Ala Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu 
            260                 265                 270         


Asp His Thr Ile Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys 
        275                 280                 285             


Ile Gly His Phe Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr 
    290                 295                 300                 


Arg Leu Met Ala Cys Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys 
305                 310                 315                 320 


Asp Glu Gly His Cys Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr 
                325                 330                 335     


Ser Ala Glu Cys Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe 
            340                 345                 350         


Gly Gly Asn Gly Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg 
        355                 360                 365             


Asp Ala Lys Leu Tyr Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg 
    370                 375                 380                 


Leu Val Ile Gly Arg Ala Phe Asn Ala Asp Phe His 
385                 390                 395     


<210>  29
<211>  4286
<212>  DNA
<213>  Homo sapiens

<400>  29
caacttccgg gtcaaaggtg cctgagccgg cgggtcccct gtgtccgccg cggctgtcgt       60

cccccgctcc cgccacttcc ggggtcgcag tcccgggcat ggagccgcga ccgtgaggcg      120

ccgctggacc cgggacgacc tgcccagtcc ggccgccgcc ccacgtcccg gtctgtgtcc      180

cacgcctgca gctggaatgg aggctctctg gaccctttag aaggcacccc tgccctcctg      240

aggtcagctg agcggttaat gcggaaggtt aagaaactgc gcctggacaa ggagaacacc      300

ggaagttgga gaagcttctc gctgaattcc gagggggctg agaggatggc caccaccggg      360

accccaacgg ccgaccgagg cgacgcagcc gccacagatg acccggccgc ccgcttccag      420

gtgcagaagc actcgtggga cgggctccgg agcatcatcc acggcagccg caagtactcg      480

ggcctcattg tcaacaaggc gccccacgac ttccagtttg tgcagaagac ggatgagtct      540

gggccccact cccaccgcct ctactacctg ggaatgccat atggcagccg agagaactcc      600

ctcctctact ctgagattcc caagaaggtc cggaaagagg ctctgctgct cctgtcctgg      660

aagcagatgc tggatcattt ccaggccacg ccccaccatg gggtctactc tcgggaggag      720

gagctgctga gggagcggaa acgcctgggg gtcttcggca tcacctccta cgacttccac      780

agcgagagtg gcctcttcct cttccaggcc agcaacagcc tcttccactg ccgcgacggc      840

ggcaagaacg gcttcatggt gtcccctatg aaaccgctgg aaatcaagac ccagtgctca      900

gggccccgga tggaccccaa aatctgccct gccgaccctg ccttcttctc cttcatcaat      960

aacagcgacc tgtgggtggc caacatcgag acaggcgagg agcggcggct gaccttctgc     1020

caccaaggtt tatccaatgt cctggatgac cccaagtctg cgggtgtggc caccttcgtc     1080

atacaggaag agttcgaccg cttcactggg tactggtggt gccccacagc ctcctgggaa     1140

ggttcagagg gcctcaagac gctgcgaatc ctgtatgagg aagtcgatga gtccgaggtg     1200

gaggtcattc acgtcccctc tcctgcgcta gaagaaagga agacggactc gtatcggtac     1260

cccaggacag gcagcaagaa tcccaagatt gccttgaaac tggctgagtt ccagactgac     1320

agccagggca agatcgtctc gacccaggag aaggagctgg tgcagccctt cagctcgctg     1380

ttcccgaagg tggagtacat cgccagggcc gggtggaccc gggatggcaa atacgcctgg     1440

gccatgttcc tggaccggcc ccagcagtgg ctccagctcg tcctcctccc cccggccctg     1500

ttcatcccga gcacagagaa tgaggagcag cggctagcct ctgccagagc tgtccccagg     1560

aatgtccagc cgtatgtggt gtacgaggag gtcaccaacg tctggatcaa tgttcatgac     1620

atcttctatc ccttccccca atcagaggga gaggacgagc tctgctttct ccgcgccaat     1680

gaatgcaaga ccggcttctg ccatttgtac aaagtcaccg ccgttttaaa atcccagggc     1740

tacgattgga gtgagccctt cagccccggg gaagatgaat ttaagtgccc cattaaggaa     1800

gagattgctc tgaccagcgg tgaatgggag gttttggcga ggcacggctc caagatctgg     1860

gtcaatgagg agaccaagct ggtgtacttc cagggcacca aggacacgcc gctggagcac     1920

cacctctacg tggtcagcta tgaggcggcc ggcgagatcg tacgcctcac cacgcccggc     1980

ttctcccata gctgctccat gagccagaac ttcgacatgt tcgtcagcca ctacagcagc     2040

gtgagcacgc cgccctgcgt gcacgtctac aagctgagcg gccccgacga cgaccccctg     2100

cacaagcagc cccgcttctg ggctagcatg atggaggcag ccagctgccc cccggattat     2160

gttcctccag agatcttcca tttccacacg cgctcggatg tgcggctcta cggcatgatc     2220

tacaagcccc acgccttgca gccagggaag aagcacccca ccgtcctctt tgtatatgga     2280

ggcccccagg tgcagctggt gaataactcc ttcaaaggca tcaagtactt gcggctcaac     2340

acactggcct ccctgggcta cgccgtggtt gtgattgacg gcaggggctc ctgtcagcga     2400

gggcttcggt tcgaaggggc cctgaaaaac caaatgggcc aggtggagat cgaggaccag     2460

gtggagggcc tgcagttcgt ggccgagaag tatggcttca tcgacctgag ccgagttgcc     2520

atccatggct ggtcctacgg gggcttcctc tcgctcatgg ggctaatcca caagccccag     2580

gtgttcaagg tggccatcgc gggtgccccg gtcaccgtct ggatggccta cgacacaggg     2640

tacactgagc gctacatgga cgtccctgag aacaaccagc acggctatga ggcgggttcc     2700

gtggccctgc acgtggagaa gctgcccaat gagcccaacc gcttgcttat cctccacggc     2760

ttcctggacg aaaacgtgca ctttttccac acaaacttcc tcgtctccca actgatccga     2820

gcagggaaac cttaccagct ccagatctac cccaacgaga gacacagtat tcgctgcccc     2880

gagtcgggcg agcactatga agtcacgttg ctgcactttc tacaggaata cctctgagcc     2940

tgcccaccgg gagccgccac atcacagcac aagtggctgc agcctccgcg gggaaccagg     3000

cgggagggac tgagtggccc gcgggcccca gtgaggcact ttgtcccgcc cagcgctggc     3060

cagccccgag gagccgctgc cttcaccgcc ccgacgcctt ttatcctttt ttaaacgctc     3120

ttgggtttta tgtccgctgc ttcttggttg ccgagacaga gagatggtgg tctcgggcca     3180

gcccctcctc tccccgcctt ctgggaggag gaggtcacac gctgatgggc actggagagg     3240

ccagaagaga ctcagaggag cgggctgcct tccgcctggg gctccctgtg acctctcagt     3300

cccctggccc ggccagccac cgtccccagc acccaagcat gcaattgcct gtcccccccg     3360

gccagcctcc ccaacttgat gtttgtgttt tgtttggggg gatatttttc ataattattt     3420

aaaagacagg ccgggcgcgg tggctcacgt ctgtaatccc agcactttgg gaggctgagg     3480

cgggcggatc acctgaggtt gggagttcaa gaccagcctg gccaacatgg ggaaaccccg     3540

tctctactaa aaatacaaaa aattagccgg gtgtggtggc gcgtgcctat aatcccagct     3600

actcgggagg ctgaggcagg agaatcgctt gaacccggga ggtggaggtt gcggtgagcc     3660

aagatcgcac cattgcactc cagcctgggc aacaagagcg aaactctgtc tcaaaataaa     3720

taaaaaataa aagacagaaa gcaaggggtg cctaaatcta gacttggggt ccacaccggg     3780

cagcggggtt gcaacccagc acctggtagg ctccatttct tcccaagccc gagcagaggg     3840

tcatgcgggc cccacaggag aagcggccag ggcccgcggg gggcaccacc tgtggacagc     3900

cctcctgtcc ccaagctttc aggcaggcac tgaaacgcac cgaacttcca cgctctgctg     3960

gtcagtggcg gctgtcccct ccccagccca gccgcccagc cacatgtgtc tgcctgaccc     4020

gtacacacca ggggttccgg ggttgggagc tgaaccatcc ccacctcagg gttatatttc     4080

cctctcccct tccctccccg ccaagagctc tgccaggggc gggcaaaaaa aaaagtaaaa     4140

agaaaagaaa aaaaaaaaaa agaaacaaac cacctctaca tattatggaa agaaaatatt     4200

tttgtcgatt cttattcttt tataattatg cgtggaagaa gtagacacat taaacgattc     4260

cagttggaaa aaaaaaaaaa aaaaaa                                          4286


<210>  30
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser 
1               5                   10                  15      


Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr 
            20                  25                  30          


Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp 
        35                  40                  45              


Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg 
    50                  55                  60                  


Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys 
65                  70                  75                  80  


Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro 
                85                  90                  95      


His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu 
            100                 105                 110         


Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala 
        115                 120                 125             


Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr 
    130                 135                 140                 


Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg 
145                 150                 155                 160 


Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu 
                165                 170                 175     


Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg 
            180                 185                 190         


Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu 
        195                 200                 205             


Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro 
    210                 215                 220                 


Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val 
225                 230                 235                 240 


Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln 
                245                 250                 255     


Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr 
            260                 265                 270         


Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys 
        275                 280                 285             


Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile 
    290                 295                 300                 


Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro 
305                 310                 315                 320 


Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg 
                325                 330                 335     


Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln 
            340                 345                 350         


Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val 
        355                 360                 365             


Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala 
    370                 375                 380                 


Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg 
385                 390                 395                 400 


Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile 
                405                 410                 415     


Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val 
            420                 425                 430         


Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val 
        435                 440                 445             


Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly 
    450                 455                 460                 


Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe 
465                 470                 475                 480 


Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp 
                485                 490                 495     


Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile 
            500                 505                 510         


Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg 
        515                 520                 525             


His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe 
    530                 535                 540                 


Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser 
545                 550                 555                 560 


Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser 
                565                 570                 575     


His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr 
            580                 585                 590         


Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly 
        595                 600                 605             


Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met 
    610                 615                 620                 


Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe 
625                 630                 635                 640 


His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys 
                645                 650                 655     


Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val 
            660                 665                 670         


Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile 
        675                 680                 685             


Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val 
    690                 695                 700                 


Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly 
705                 710                 715                 720 


Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu 
                725                 730                 735     


Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg 
            740                 745                 750         


Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly 
        755                 760                 765             


Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro 
    770                 775                 780                 


Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met 
785                 790                 795                 800 


Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala 
                805                 810                 815     


Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu 
            820                 825                 830         


His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu 
        835                 840                 845             


Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr 
    850                 855                 860                 


Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr 
865                 870                 875                 880 


Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
                885                 890         


<210>  31
<211>  2113
<212>  DNA
<213>  Homo sapiens

<400>  31
actcaccctc cggcttcctg tcggggcttt ctcagcccca ccccacgttt ggacatttgg       60

agcatttcct tccctgacag ccggacctgg gactgggctg gggccctggc ggatggagac      120

atgctgcccc tgctgctgct gcccctgctg tggggggggt ccctgcagga gaagccagtg      180

tacgagctgc aagtgcagaa gtcggtgacg gtgcaggagg gcctgtgcgt ccttgtgccc      240

tgctccttct cttacccctg gagatcctgg tattcctctc ccccactcta cgtctactgg      300

ttccgggacg gggagatccc atactacgct gaggttgtgg ccacaaacaa cccagacaga      360

agagtgaagc cagagaccca gggccgattc cgcctccttg gggatgtcca gaagaagaac      420

tgctccctga gcatcggaga tgccagaatg gaggacacgg gaagctattt cttccgcgtg      480

gagagaggaa gggatgtaaa atatagctac caacagaata agctgaactt ggaggtgaca      540

gccctgatag agaaacccga catccacttt ctggagcctc tggagtccgg ccgccccaca      600

aggctgagct gcagccttcc aggatcctgt gaagcgggac cacctctcac attctcctgg      660

acggggaatg ccctcagccc cctggacccc gagaccaccc gctcctcgga gctcaccctc      720

acccccaggc ccgaggacca tggcaccaac ctcacctgtc aggtgaaacg ccaaggagct      780

caggtgacca cggagagaac tgtccagctc aatgtctcct atgctccaca gaacctcgcc      840

atcagcatct tcttcagaaa tggcacaggc acagccctgc ggatcctgag caatggcatg      900

tcggtgccca tccaggaggg ccagtccctg ttcctcgcct gcacagttga cagcaacccc      960

cctgcctcac tgagctggtt ccgggaggga aaagccctca atccttccca gacctcaatg     1020

tctgggaccc tggagctgcc taacatagga gctagagagg gaggggaatt cacctgccgg     1080

gttcagcatc cgctgggctc ccagcacctg tccttcatcc tttctgtgca gagaagctcc     1140

tcttcctgca tatgtgtaac tgagaaacag cagggctcct ggcccctcgt cctcaccctg     1200

atcagggggg ctctcatggg ggctggcttc ctcctcacct atggcctcac ctggatctac     1260

tataccaggt gtggaggccc ccagcagagc agggctgaga ggcctggctg agcccctccc     1320

gctcaagaca gaactgaggt gtggacactt agccctgtgg gacacatgca ggacatcact     1380

gtcagcttct ttctggaagc tcacatccca ctgactaccc ctcttttcct tcctgcccca     1440

taccccttct acttattccc ctctgcttgt gagtcttgcc ccaccacacc tgcatcccca     1500

tctgcacccc atcccctctc cacctgccct tctcttccct ctccatccac catctccagc     1560

cctgtgaagg gaatgtactt tcggtcttat acccccatta cccattaccc aaaagttacc     1620

tttttttttt tttttttttt ttgagacaga gtctcactct gttgcacagg ctggagttca     1680

gtggcacaat ctccgttcac tgcaacctcc acctctgggg ttcaagcaat tctcctgcct     1740

cagcctccct agtagctggg attacaggtg cctgccacca catccagtta attttttttt     1800

tttgtatgtt agtagagatg gggttttacc atgttggcca ggtctcgaac tcctgacctc     1860

aagcaatcca ctgcattggc ctcccaaagt gctggcatta caggtatgag ccaccgtgcc     1920

tggctgccaa aagttacctt cttaacactt gaatttctgg tctcctcagc ttccctatcc     1980

atataggcac agagaggcag catttgtttt ccagttaaaa ctctacctca ttgtgattat     2040

tatccaatac aattgttaca aaataagtaa aacttttatg aaacaataca acataactga     2100

ttttactctt taa                                                        2113


<210>  32
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln 
1               5                   10                  15      


Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
        35                  40                  45              


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
    50                  55                  60                  


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
65                  70                  75                  80  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
                85                  90                  95      


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
            100                 105                 110         


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
        115                 120                 125             


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
    130                 135                 140                 


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
145                 150                 155                 160 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
                165                 170                 175     


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
            180                 185                 190         


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
        195                 200                 205             


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
    210                 215                 220                 


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
225                 230                 235                 240 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
                245                 250                 255     


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
            260                 265                 270         


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
        275                 280                 285             


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
    290                 295                 300                 


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
305                 310                 315                 320 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
                325                 330                 335     


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
            340                 345                 350         


Ser Trp Pro Leu Val Leu Thr Leu Ile Arg Gly Ala Leu Met Gly Ala 
        355                 360                 365             


Gly Phe Leu Leu Thr Tyr Gly Leu Thr Trp Ile Tyr Tyr Thr Arg Cys 
    370                 375                 380                 


Gly Gly Pro Gln Gln Ser Arg Ala Glu Arg Pro Gly 
385                 390                 395     


<210>  33
<211>  4045
<212>  DNA
<213>  Homo sapiens

<400>  33
cgcccacgcc cggcgccccg accgcggagg actccccgag ccccgcccgc catggcccgg       60

atcccgacgg ccgccctggg ttgcatcagc ctcctctgcc tgcagctccc tggctcgctg      120

tcccgcagcc tgggcgggga cccgcgaccc gtcaaaccca gggagccccc agcccggagc      180

ccttccagca gcctgcagcc caggcacccc gcaccccgac ctgtggtctg gaagcttcac      240

cgggccctcc aggcacagag gggtgccggc ctggcccctg ttatgggtca gcctctccgg      300

gatggtggcc gccaacactc gggcccccga agacactcgg gcccccgcag gacccaagcc      360

cagctcctgc gagtgggctg tgtgctgggc acctgccagg tgcagaatct cagccaccgc      420

ctgtggcaac tcatgggacc ggccggccgg caggactcag ctcctgtgga ccccagcagc      480

ccccacagct atggctgagg tggggccggg ccacacccct gcccatccca gccagggtgc      540

tgtgcccccg tccagagctg cagctgagcc ccatctgaag cccagtccct cggagctgca      600

gacagcaggt cctgcagcaa caatacctgc acggctttgc acacgtaaac ctaggctggt      660

ctacacgcag tgctggtacg tcaaggagcc taaacaccct gaaattgtga ccccctgggg      720

gacagctgcc agacacagct ggcggcagca ccagatgcta agcgcttcag agaggaggtg      780

tctgcccaga gatgtggagc agaagctggg ccctgaacac acggggccat gtctggacga      840

gcaggggaga gaggctgaac tggccagaag tggcccctcc gctgctggtc cagtcagact      900

gaagcccggc cttgtgcctg ggctgttcct gctctcatgc acaaccagcc cttccacgtg      960

cctgcctgtg ggacaggagg gggagcgtgg gatgctgtag cccccggggt tgggcaaggg     1020

aaggatggtg gccctccaga ggtcatgaag ggacctctgt ggctccagct gccaaccctg     1080

gagcccagac cgaggtggcc atggagactc cacctggatc ccctgtagga ggccagggag     1140

gggaactcag cagttcagga gccaccccaa accattctgg gacagggaca cccctttcta     1200

ccccagggca gggcagggct gggtggggca agatccccca gcccgactag acccacctca     1260

cctgaagggg gtgagaccct tgttggcagc cagacaaggg tggggctcca caggcagcac     1320

aggcgcccca ccaccaccca gtttggggac ccagtgggac caggtgcggg ggcagagggt     1380

gacttaccaa gagccaggga gggcagccca ggcccaagtg acagcaagaa caagaaccac     1440

tgccggcgtg cacagacttg gtgtgtgtcc ttccctgggg ggacggggga ctcacatgtg     1500

cctgccactg gagcctctca accgtccagc agaacacggg gttcagaaag ggctccttct     1560

gctatttagc gaacactgag catttaattt acaaatgttt gctagggtca ccctctcggc     1620

catcccacga gggtcgccat gatcacccca actctagagg ccgcagcaga gctcaggaca     1680

ttcccccaca gagcttgccc ctcagttcct acctccaagg gggagggtcc tggaagcgcc     1740

cacccaggcg ccgcccctgt gcttgctccc cgagctcagg gattgccgag tccacgtaac     1800

tgacctgtac tccacgaggc cctgtgggaa cggtccaggc tggtcctgcc ctgtggaggc     1860

ctccgtgcac tgagagatgt actaggattg cagcaaaggt ggtcagggtg atgggccgca     1920

cagcgaggca gtcaaggcca gctccctggg agaagcactg ggtcaggtga ggtctgagga     1980

cagcaggcct tccctagggg aaggagctgg gagtgccaag gccccaggtg cacaggaggc     2040

gtggctgctg agaggctgca gggtggaggg gcctcggcct cagagtcatg tgccctgtga     2100

ccactgaagg gtgtcagcag agcacacggc atgaggacag agggaggggc acggggagtg     2160

aaggaggggg ccctggggca aggctcgggg gtcaggagct cagcgtccgc tactcagccc     2220

agccaaaacc ctcccagacg tctcctctcc tgcctgggca aagtccagct tggcaccccg     2280

tctggggcct gcctgtggtc agggccaagt gttccctcct ccaggaaagc ctttaccctc     2340

ctcatgccct gtagtcagga ggccgcctgc tgtaaccctc cgtgtcgcct cgggtgcgaa     2400

atcagaccca cctgacacca tcacgcggag gcccagcagc acctgcaccc acttccagct     2460

gctctggcca aaatctccgc tcggccaggc cccgtggctc acacctgtaa tcctagcaca     2520

ttgggaggcc aaggcaggca catcacctga gttcaggagt tcaagaccag cctggccaac     2580

atggtgaaat cccgtctcta ctaaaaacag aaaattatcc gggcgtggtg gcacatgact     2640

gtaatcccag ctactcagga ggctgaggca ggaggatcac ttgaacctgg gaggcggagg     2700

ttgcagtgag ctgagattgc gccattgcac tccagcctgg gcaacaagag caaaattctg     2760

cctcaaaaaa aaaaatagta ataatacaaa aattagctgg gcgtggtggc acatgccagt     2820

aattccatct actcgggagg ctgaggcagg agaatcgtct aagcccggga ggtggaggtt     2880

gcagtgagcc cagatggcgc tgctgcactc aagcttggat gacagagcaa gactccgttt     2940

caaaaaaaaa aaacctcctc tcttccttca caccttcctc tgaatcccac ccggtcccac     3000

ctcctgaacc tatccagaca ccttctcctg acccaggcac cacctgcttt cggggcgatg     3060

gccgtagcct cctcccaggc acctgtctgc atccctctgg ccagtgcatg ctgagcacgt     3120

gacctacccg tgttgggaca cgtgaggata cagccttgac ccccaggggc tgacattcta     3180

gggggagata gaaggagaca aacgtagaag gtagaataag tgggtggtgg agtggcaggg     3240

agtgctgagt gccacaggaa gtcagacaag gaaggagagt gtggggcagg tgccgtttaa     3300

atggggggcg ctggggtctc ctcacagttg cttctcagct cagctgtgcc aggatcttgt     3360

tgagtcaggt cagctgccca cagccctctt gcctgacccc tgaagcccag aactctgatc     3420

ttcacagccc taggtatggc cccagcaccc cactgccctc tctcctgccc cagccgactg     3480

ctgttcccag acttccctgg ccacgctcca agacgccagc tctgccgcgg gcactttgtt     3540

ctcacggtgt cctccatgcc tgcagggccc atgcatggga agttgcgttg gcggcctggg     3600

tgttggcggt tccgtgcctg ctccaactct ccgtgaggcc cctctcccag agcctgacac     3660

actctgtggc cgaactctag gcaggtgccc ctgagtcctt tcctcgacga ggcctgaccc     3720

catccccatc ctcgctgggc ccgccgaccc cggtgttagc aagaatcctc taaatcagtt     3780

tatggagaat tacccaccct cgatatctga tcccattcct catctcccac ccttgatctc     3840

atcaccctgc cggcctcctg caagatcctc attgagccac tccagtgaga atccccctac     3900

cctcgaaggc cgccctaaca acttcccatc cgctgacccc tccaacgcca tcaatctcca     3960

gctgtggttg ttgaactcgg aggtgagctc ctctcaccac tctcttgaat aaagcttttc     4020

tcaccatttt aaaaaaaaaa aaaaa                                           4045


<210>  34
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Arg Ile Pro Thr Ala Ala Leu Gly Cys Ile Ser Leu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Pro Gly Ser Leu Ser Arg Ser Leu Gly Gly Asp Pro Arg 
            20                  25                  30          


Pro Val Lys Pro Arg Glu Pro Pro Ala Arg Ser Pro Ser Ser Ser Leu 
        35                  40                  45              


Gln Pro Arg His Pro Ala Pro Arg Pro Val Val Trp Lys Leu His Arg 
    50                  55                  60                  


Ala Leu Gln Ala Gln Arg Gly Ala Gly Leu Ala Pro Val Met Gly Gln 
65                  70                  75                  80  


Pro Leu Arg Asp Gly Gly Arg Gln His Ser Gly Pro Arg Arg His Ser 
                85                  90                  95      


Gly Pro Arg Arg Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu 
            100                 105                 110         


Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met 
        115                 120                 125             


Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro 
    130                 135                 140                 


His Ser Tyr Gly 
145             


<210>  35
<211>  3406
<212>  DNA
<213>  Homo sapiens

<400>  35
aggcgggcgg agcgaggggt gggagggcgc gcgcgaacgg gcgggcgagc aagcgagcgg       60

cgtctccacc agcatctgcc gcggccgcct ttgcccgaag cccggggacg aaccgacgga      120

ccgaccgcct ggcgcacgga cgcgggcgct cgctttgtgt tcggggctag cgtcggcgag      180

gcttgagctt gcagcgcgcg gcttccctgc tttctcgcgg ccaccccggc tccggcggcc      240

tcggcgcgcg aggggctgga ggtgcgggag ccgctctccg ccggtcggtc cccgcgcggc      300

tgagcccagg ccgccagcgc cgcggccccg tgcggtgtcc ctgagctcct gctccccgcc      360

gggctgctcc gagcaacggt gcttcggagc tccaaactcg ggctgccggg gcaagtgtct      420

tcatgaaccc agaggatgtc cgggaagcac tacaagggtc ctgaagtcag ttgttgcatc      480

aaatacttca tatttggctt caatgtcata ttttggtttt tgggaataac atttcttgga      540

attggactgt gggcatggaa tgaaaaagga gttctgtcca acatctcttc catcaccgat      600

ctcggcggct ttgacccagt ttggctcttc cttgtggtgg gaggagtgat gttcattttg      660

ggatttgcag ggtgcattgg agcgctacgg gaaaacactt tccttctcaa gtttttttct      720

gtgttcctgg gaattatttt cttcctggag ctcactgccg gagttctagc atttgttttc      780

aaagactgga tcaaagacca gctgtatttc tttataaaca acaacatcag agcatatcgg      840

gatgacattg atttgcaaaa cctcatagac ttcacccagg aatattggca gtgctgtggg      900

gcttttggag ctgatgattg gaacctaaat atttacttca attgcacaga ttccaatgca      960

agtcgagagc gatgtggcgt tccattctcc tgctgcacta aagatcccgc agaagatgtc     1020

atcaacactc agtgtggcta tgatgccagg caaaaaccag aagttgacca gcagattgta     1080

atctacacga aaggctgtgt gccccagttt gagaagtggt tgcaggacaa tttaaccatc     1140

gttgctggta ttttcatagg cattgcattg ctgcagatat ttgggatatg cctggcccag     1200

aatttggtta gcgatatcga agctgtcagg gcgagctggt agaccccctg caaccgctgc     1260

tgcaagacac tggacagacc cagctttcgg gaccctcccg cgtgccgaac tgatcttcga     1320

gctgcatgga cctaatcaca gatgcagcct gcagtctcgc ctaatggagc tgccattagg     1380

ggagtgtaaa actgggaaat gctgctcact gacagaatta aaaaaaaaaa taaccagtat     1440

gaaagtcgtt gcgccgtgaa tctctactgt agccatgaat ttatggacag ttagatgctt     1500

accaaaaaag aaaaaaaggg agggtagggg acccagatgt acttgaatgt gcagaaaata     1560

cattcttgtc ctcatcttcc gtaattggag ggctgggaga ggcagctttg ctcttcacca     1620

caccttggac ggaccacctt ctttctgttc catggcctga aggagtgcat ctcctcaaag     1680

actcagcccc tcacctggga gggcagtggt ttgtgggcat ccctccatgt acattttagg     1740

aaacacttgc aactctcatc tgaagaagaa aacaactcat ctttgggttc agattttgtg     1800

atggtattca gcaagtcact tgggcgagca cacttggtct atcctggaaa gtctccttat     1860

aagagaagtt gtgtatttca tgtgcaccga gcaagggcat tggaagacgt catgaggctg     1920

tattttagca ggactgatcg tttttctaag tagacctgag ctttgtttat cagtgaaatt     1980

caaggagaaa atgaggttaa tgaagaggta tcagttaaat atccccttct tctcaccctg     2040

ccaaaattag cagttggatt tttggaaact ctggaatatt ctgggtcatt ttgttttgta     2100

tgtttgttgt ttttcgtctt ccaaaggtga aagctatgat acagttccac ttaaatttta     2160

gtgttttctt actcagctca agcattaatt tttgattaag tcttaatctg catgacctgt     2220

gaatctgaat ccatcatctc cctttcctgc cagcttttct acaaacattg aaatatgtta     2280

tttggtcagc acttatttcc taggttcaca gccttgggag gttgtggcat gtcctcccag     2340

tctggctggg aagagaccag ctgtaccatc caaatgcttc cctggtcttg atgatctctt     2400

ccagagtcga tctgagtggc cttttctgca ccctcccctt ctttctcttt gaatggaatt     2460

aaacccaatt tggaaacaac attgacccag tcaaaagctt ctaatggttt ctttttcttc     2520

ctccagtttt agtttgcttt tattaaaaaa agaaaatagt gcatggccat agctccttca     2580

gttctcttat tgcagactaa ccatcaggat ggtatcaaag cacaaatact ttggagggga     2640

atgcgttgaa ctggggcaag tactctgtaa cacaaagtgg gaaaccactt cctggtgctg     2700

ccgctcctgc ccccacttta ggtgggaggg acgagttttg ccctctagat tttaatccag     2760

ctggtgtcca ccggatgttg ccctcctggg gagcagatat cagtctgtgg aactctggga     2820

aaaccacagg cacatttttc ggtgcggaca gatttgccag cacataactg ggcagccagc     2880

tagaatactt tgtggaaatt aagcgaggtt ttccatttca gccccatggt gcatggtggt     2940

ggccgatgaa tgtgtcagtc tgctcagaga aaggacaaaa aggaaattat tttcaaaact     3000

gtgttcactg tttgggtgtg tgtatggctc tgcatgtgtg tgtttttgtc tctgtatagg     3060

tagaggtatt cacatcttac tccgactgta aggttgtctt acttcatctc tgcccccacc     3120

acagttgcca ttttgtaatg tccttccaac atggagaaga cacgagctct ctccagttgg     3180

catcatttgt cttttttgtt gattgcctca ttctccagtg aactccatct ggccaattga     3240

ttcagaatca ggcaagatcc ctgccctttg gcacatccac tgaaaggcca aacagcaagt     3300

ccgagtgagt tttaaatatt aattaatcac cctttatttt ttacacttga gagtgattgt     3360

aataaaggct gtcattaata aacttggttc taccttaaaa aaaaaa                    3406


<210>  36
<211>  5882
<212>  DNA
<213>  Homo sapiens

<400>  36
atcaaatttc aactccaggc agtccttcca gccatgtggg ttcagcggaa agagaagcaa       60

aaccactctt cctaaaatgt tagaagctgc tcttcgctta ccttggggcc tttgcattgg      120

gagctgtttt tcacatcaaa gaatatgtgc tgaatggaat tttagtattt tgctgtcgtt      180

ttaatatttt cgtctggtct tcctcagttc ttccagacgc tttctgagag aatgggggca      240

ggagctctag ccatctgtca aagtaaagca gcggttcggc tgaaagaaga catgaaaaag      300

atagtggcag tgccattaaa tgaacagaag gattttacct atcagaagtt atttggagtc      360

agtctccaag aacttgaacg gcaggggctc accgagaatg gcattccagc agtagtgtgg      420

aatatagtgg aatatttgac gcagcatgga cttacccaag aaggtctttt tagggtgaat      480

ggtaacgtga aggtggtgga acaacttcga ctgaagttcg agagtggagt gcccgtggag      540

ctcgggaagg acggtgatgt ctgctcagca gccagtctgt tgaagctgtt tctgagggag      600

ctgcctgaca gtctgatcac ctcagcgttg cagcctcgat tcattcaact ctttcaggat      660

ggcagaaatg atgttcagga gagtagctta agagacttaa taaaagagct gccagacacc      720

cactactgcc tcctcaagta cctttgccag ttcttgacaa aagtagccaa gcatcatgtg      780

cagaatcgca tgaatgttca caatctcgcc actgtatttg ggccaaattg ctttcatgtg      840

ccacctgggc ttgaaggcat gaaggaacag gacctgtgca acaagataat ggctaaaatt      900

ctagaaaatt acaataccct gtttgaagta gagtatacag aaaatgatca tctgagatgt      960

gaaaacctgg ctaggcttat catagtaaaa gaggtctatt ataagaactc cctgcccatc     1020

cttttaacaa gaggcttaga aagagacatg ccaaaaccac ctccaaaaac caagatccca     1080

aaatccagga gtgagggatc tattcaggcc cacagagtac tgcaaccaga gctatctgat     1140

ggcattcctc agctcagctt gcggctaagt tatagaaaag cctgcttgga agacatgaat     1200

tcagcagagg gtgctattag tgccaagttg gtacccagtt cacaggaaga tgaaagacct     1260

ctgtcacctt tctatttgag tgctcatgta ccccaagtca gcaatgtgtc tgcaaccgga     1320

gaactcttag aaagaaccat ccgatcagct gtagaacaac atctttttga tgttaataac     1380

tctggaggtc aaagttcaga ggactcagaa tctggaacac tatcagcatc ttctgccaca     1440

tctgccagac agcgccgccg ccagtccaag gagcaggatg aagttcgaca tgggagagac     1500

aagggactta tcaacaaaga aaatactcct tctgggttca accaccttga tgattgtatt     1560

ttgaatactc aggaagtcga aaaggtacac aaaaatactt ttggttgtgc tggagaaagg     1620

agcaagccta aacgtcagaa atccagtact aaactttctg agcttcatga caatcaggac     1680

ggtcttgtga atatggaaag tctcaattcc acacgatctc atgagagaac tggacctgat     1740

gattttgaat ggatgtctga tgaaaggaaa ggaaatgaaa aagatggtgg acacactcag     1800

cattttgaga gccccacaat gaagatccag gagcatccca gcctatctga caccaaacag     1860

cagagaaatc aagatgccgg tgaccaggag gagagctttg tctccgaagt gccccagtcg     1920

gacctgactg cattgtgtga tgaaaagaac tgggaagagc ctatccctgc tttctcctcc     1980

tggcagcggg agaacagtga ctctgatgaa gcccacctct cgccgcaggc tgggcgcctg     2040

atccgtcagc tgctggacga agacagcgac cccatgctct ctcctcggtt ctacgcttat     2100

gggcagagca ggcaatacct ggatgacaca gaagtgcctc cttccccacc aaactcccat     2160

tctttcatga ggcggcgaag ctcctctctg gggtcctatg atgatgagca agaggacctg     2220

acacctgccc agctcacacg aaggattcag agccttaaaa agaagatccg gaagtttgaa     2280

gatagattcg aagaagagaa gaagtacaga ccttcccaca gtgacaaagc agccaatccg     2340

gaggttctga aatggacaaa tgaccttgcc aaattccgga gacaacttaa agaatcaaaa     2400

ctaaagatat ctgaagagga cctaactccc aggatgcggc agcgaagcaa cacactcccc     2460

aagagttttg gttcccaact tgagaaagaa gatgagaaga agcaagagct ggtggataaa     2520

gcaataaagc ccagtgttga agccacattg gaatctattc agaggaagct ccaggagaag     2580

cgagcggaaa gcagccgccc tgaggacatt aaggatatga ccaaagacca gattgctaat     2640

gagaaagtgg ctctgcagaa agctctgtta tattatgaaa gcattcatgg acggccggta     2700

acaaagaacg aacggcaggt gatgaagcca ctatacgaca ggtaccggct ggtcaaacag     2760

atcctctccc gagctaacac catacccatc attggttccc cctccagcaa gcggagaagc     2820

cctttgctgc agccaattat cgagggcgaa actgcttcct tcttcaagga gataaaggaa     2880

gaagaggagg ggtcagaaga cgatagcaat gtgaagccag acttcatggt cactctgaaa     2940

accgatttca gtgcacgatg ctttctggac caattcgaag atgacgctga tggatttatt     3000

tccccaatgg atgataaaat accatcaaaa tgcagccagg acacagggct ttcaaatctc     3060

catgctgcct caatacctga actcctggaa cacctccagg aaatgagaga agaaaagaaa     3120

aggattcgaa agaaacttcg ggattttgaa gacaactttt tcagacagaa tggaagaaat     3180

gtccagaagg aagaccgcac tcctatggct gaagaataca gtgaatataa gcacataaag     3240

gcgaaactga ggctcctgga ggtgctcatc agcaagagag acactgattc caagtccatg     3300

tgaggggcat ggccaagcac agggggctgg cagctgcggt gagagtttac tgtccccaga     3360

gaaagtgcag ctctggaagg cagccttggg gctggccctg caaagcatgc agcccttctg     3420

cctctagacc atttggcatc ggctcctgtt tccattgcct gccttagaaa ctggctggaa     3480

gaagacaatg tgacctgact taggcatttt gtaattggaa agtcaagact gcagtatgtg     3540

cacatgcgca cgcgcatgca cgcacacaca cacacagtag tggagctttc ctaacactag     3600

cagagattaa tcactacatt agacaacact catctacaga gaatatacac tgttcttccc     3660

tggataactg agaaacaaga gaccattctc tgtctaactg tgataaaaac aagctcagga     3720

ctttattcta tagagcaaac ttgctgtgga gggccatgct ctccttggac ccagttaact     3780

gcaaacgtgc attggagccc tatttgctgc cgctgccatt ctagtgacct ttccacagag     3840

ctgcgccttc ctcacgtgtg tgaaaggttt tccccttcag ccctcaggta gatggaagct     3900

gcatctgccc acgatggcag tgcagtcatc atcttcagga tgtttcttca ggacttcctc     3960

agctgacaag gaattttggt ccctgcctag gaccgggtca tctgcagagg acagagagat     4020

ggtaagcagc tgtatgaatg ctgattttaa aaccaggtca tgggagaaga gcctggagat     4080

tctttcctga acactgactg cacttaccag tctgatttta tcgtcaaaca ccaagccagg     4140

ctagcatgct catggcaatc tgtttggggc tgttttgttg tggcactagc caaacataaa     4200

ggggcttaag tcagcctgca tacagaggat cggggagaga aggggcctgt gttctcagcc     4260

tcctgagtac ttaccagagt ttaatttttt taaaaaaaat ctgcactaaa atccccaaac     4320

tgacaggtaa atgtagccct cagagctcag cccaaggcag aatctaaatc acactatttt     4380

cgagatcatg tataaaaaga aaaaaaagaa gtcatgctgt gtggccaatt ataatttttt     4440

tcaaagactt tgtcacaaaa ctgtctatat tagacatttt ggagggacca ggaaatgtaa     4500

gacaccaaat cctccatctc ttcagtgtgc ctgatgtcac ctcatgattt gctgttactt     4560

ttttaactcc tgcgccaagg acagtgggtt ctgtgtccac ctttgtgctt tgcgaggccg     4620

agcccaggca tctgctcgcc tgccacggct gaccagagaa ggtgcttcag gagctctgcc     4680

ttagacgacg tgttacagta tgaacacaca gcagaggcac cctcgtatgt tttgaaagtt     4740

gccttctgaa agggcacagt tttaaggaaa agaaaaagaa tgtaaaacta tactgacccg     4800

ttttcagttt taaagggtcg tgagaaactg gctggtccaa tgggatttac agcaacattt     4860

tccattgctg aagtgaggta gcagctctct tctgtcagct gaatgttaag gatggggaaa     4920

aagaatgcct ttaagtttgc tcttaatcgt atggaagctt gagctatgtg ttggaagtgc     4980

cctggtttta atccatacac aaagacggta cataatccta caggtttaaa tgtacataaa     5040

aatatagttt ggaattcttt gctctactgt ttacattgca gattgctata atttcaagga     5100

gtgagattat aaataaaatg atgcacttta ggatgtttcc tatttttgaa atctgaacat     5160

gaatcattca catgaccaaa aattgtgttt ttttaaaaat acatgtctag tctgtccttt     5220

aatagctctc ttaaataagc tatgatatta atcagatcat taccagttag cttttaaagc     5280

acatttgttt aagactatgt ttttggaaaa atacgctaca gaattttttt ttaagctaca     5340

aataaatgag atgctactaa ttgttttgga atctgttgtt tctgccaaag gtaaattaac     5400

taaagattta ttcaggaatc cccatttgaa tttgtatgat tcaataaaag aaaacaccaa     5460

gtaagttata taaaataaat tgtgtatgag atgttgtgtt ttcctttgta atttccacta     5520

actaactaac taacttatat tcttcatgga atggagccca gaagaaatga gaggaagccc     5580

ttttcacact agatcttatt tgaagaaatg tttgttagtc agtcagtcag tggtttctgg     5640

ctctgccgag ggagatgtgt tccccagcaa ccatttctgc agcccagaat ctcaaggcac     5700

tagaggcggt gtcttaatta attggcttca caaagacaaa atgctctgga ctgggatttt     5760

tcctttgctg tgttgggaat atgtgtttat taattagcac atgccaacaa aataaatgtc     5820

aagagttatt tcataagtgt aagtaaactt aagaattaaa gagtgcagac ttataatttt     5880

ca                                                                    5882


<210>  37
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ala Gly Ala Leu Ala Ile Cys Gln Ser Lys Ala Ala Val Arg 
1               5                   10                  15      


Leu Lys Glu Asp Met Lys Lys Ile Val Ala Val Pro Leu Asn Glu Gln 
            20                  25                  30          


Lys Asp Phe Thr Tyr Gln Lys Leu Phe Gly Val Ser Leu Gln Glu Leu 
        35                  40                  45              


Glu Arg Gln Gly Leu Thr Glu Asn Gly Ile Pro Ala Val Val Trp Asn 
    50                  55                  60                  


Ile Val Glu Tyr Leu Thr Gln His Gly Leu Thr Gln Glu Gly Leu Phe 
65                  70                  75                  80  


Arg Val Asn Gly Asn Val Lys Val Val Glu Gln Leu Arg Leu Lys Phe 
                85                  90                  95      


Glu Ser Gly Val Pro Val Glu Leu Gly Lys Asp Gly Asp Val Cys Ser 
            100                 105                 110         


Ala Ala Ser Leu Leu Lys Leu Phe Leu Arg Glu Leu Pro Asp Ser Leu 
        115                 120                 125             


Ile Thr Ser Ala Leu Gln Pro Arg Phe Ile Gln Leu Phe Gln Asp Gly 
    130                 135                 140                 


Arg Asn Asp Val Gln Glu Ser Ser Leu Arg Asp Leu Ile Lys Glu Leu 
145                 150                 155                 160 


Pro Asp Thr His Tyr Cys Leu Leu Lys Tyr Leu Cys Gln Phe Leu Thr 
                165                 170                 175     


Lys Val Ala Lys His His Val Gln Asn Arg Met Asn Val His Asn Leu 
            180                 185                 190         


Ala Thr Val Phe Gly Pro Asn Cys Phe His Val Pro Pro Gly Leu Glu 
        195                 200                 205             


Gly Met Lys Glu Gln Asp Leu Cys Asn Lys Ile Met Ala Lys Ile Leu 
    210                 215                 220                 


Glu Asn Tyr Asn Thr Leu Phe Glu Val Glu Tyr Thr Glu Asn Asp His 
225                 230                 235                 240 


Leu Arg Cys Glu Asn Leu Ala Arg Leu Ile Ile Val Lys Glu Val Tyr 
                245                 250                 255     


Tyr Lys Asn Ser Leu Pro Ile Leu Leu Thr Arg Gly Leu Glu Arg Asp 
            260                 265                 270         


Met Pro Lys Pro Pro Pro Lys Thr Lys Ile Pro Lys Ser Arg Ser Glu 
        275                 280                 285             


Gly Ser Ile Gln Ala His Arg Val Leu Gln Pro Glu Leu Ser Asp Gly 
    290                 295                 300                 


Ile Pro Gln Leu Ser Leu Arg Leu Ser Tyr Arg Lys Ala Cys Leu Glu 
305                 310                 315                 320 


Asp Met Asn Ser Ala Glu Gly Ala Ile Ser Ala Lys Leu Val Pro Ser 
                325                 330                 335     


Ser Gln Glu Asp Glu Arg Pro Leu Ser Pro Phe Tyr Leu Ser Ala His 
            340                 345                 350         


Val Pro Gln Val Ser Asn Val Ser Ala Thr Gly Glu Leu Leu Glu Arg 
        355                 360                 365             


Thr Ile Arg Ser Ala Val Glu Gln His Leu Phe Asp Val Asn Asn Ser 
    370                 375                 380                 


Gly Gly Gln Ser Ser Glu Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser 
385                 390                 395                 400 


Ser Ala Thr Ser Ala Arg Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp 
                405                 410                 415     


Glu Val Arg His Gly Arg Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr 
            420                 425                 430         


Pro Ser Gly Phe Asn His Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu 
        435                 440                 445             


Val Glu Lys Val His Lys Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser 
    450                 455                 460                 


Lys Pro Lys Arg Gln Lys Ser Ser Thr Lys Leu Ser Glu Leu His Asp 
465                 470                 475                 480 


Asn Gln Asp Gly Leu Val Asn Met Glu Ser Leu Asn Ser Thr Arg Ser 
                485                 490                 495     


His Glu Arg Thr Gly Pro Asp Asp Phe Glu Trp Met Ser Asp Glu Arg 
            500                 505                 510         


Lys Gly Asn Glu Lys Asp Gly Gly His Thr Gln His Phe Glu Ser Pro 
        515                 520                 525             


Thr Met Lys Ile Gln Glu His Pro Ser Leu Ser Asp Thr Lys Gln Gln 
    530                 535                 540                 


Arg Asn Gln Asp Ala Gly Asp Gln Glu Glu Ser Phe Val Ser Glu Val 
545                 550                 555                 560 


Pro Gln Ser Asp Leu Thr Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu 
                565                 570                 575     


Pro Ile Pro Ala Phe Ser Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp 
            580                 585                 590         


Glu Ala His Leu Ser Pro Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu 
        595                 600                 605             


Asp Glu Asp Ser Asp Pro Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly 
    610                 615                 620                 


Gln Ser Arg Gln Tyr Leu Asp Asp Thr Glu Val Pro Pro Ser Pro Pro 
625                 630                 635                 640 


Asn Ser His Ser Phe Met Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr 
                645                 650                 655     


Asp Asp Glu Gln Glu Asp Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile 
            660                 665                 670         


Gln Ser Leu Lys Lys Lys Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu 
        675                 680                 685             


Glu Lys Lys Tyr Arg Pro Ser His Ser Asp Lys Ala Ala Asn Pro Glu 
    690                 695                 700                 


Val Leu Lys Trp Thr Asn Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys 
705                 710                 715                 720 


Glu Ser Lys Leu Lys Ile Ser Glu Glu Asp Leu Thr Pro Arg Met Arg 
                725                 730                 735     


Gln Arg Ser Asn Thr Leu Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys 
            740                 745                 750         


Glu Asp Glu Lys Lys Gln Glu Leu Val Asp Lys Ala Ile Lys Pro Ser 
        755                 760                 765             


Val Glu Ala Thr Leu Glu Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg 
    770                 775                 780                 


Ala Glu Ser Ser Arg Pro Glu Asp Ile Lys Asp Met Thr Lys Asp Gln 
785                 790                 795                 800 


Ile Ala Asn Glu Lys Val Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu 
                805                 810                 815     


Ser Ile His Gly Arg Pro Val Thr Lys Asn Glu Arg Gln Val Met Lys 
            820                 825                 830         


Pro Leu Tyr Asp Arg Tyr Arg Leu Val Lys Gln Ile Leu Ser Arg Ala 
        835                 840                 845             


Asn Thr Ile Pro Ile Ile Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro 
    850                 855                 860                 


Leu Leu Gln Pro Ile Ile Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu 
865                 870                 875                 880 


Ile Lys Glu Glu Glu Glu Gly Ser Glu Asp Asp Ser Asn Val Lys Pro 
                885                 890                 895     


Asp Phe Met Val Thr Leu Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu 
            900                 905                 910         


Asp Gln Phe Glu Asp Asp Ala Asp Gly Phe Ile Ser Pro Met Asp Asp 
        915                 920                 925             


Lys Ile Pro Ser Lys Cys Ser Gln Asp Thr Gly Leu Ser Asn Leu His 
    930                 935                 940                 


Ala Ala Ser Ile Pro Glu Leu Leu Glu His Leu Gln Glu Met Arg Glu 
945                 950                 955                 960 


Glu Lys Lys Arg Ile Arg Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe 
                965                 970                 975     


Phe Arg Gln Asn Gly Arg Asn Val Gln Lys Glu Asp Arg Thr Pro Met 
            980                 985                 990         


Ala Glu Glu Tyr Ser Glu Tyr Lys  His Ile Lys Ala Lys  Leu Arg Leu 
        995                 1000                 1005             


Leu Glu  Val Leu Ile Ser Lys  Arg Asp Thr Asp Ser  Lys Ser Met 
    1010                 1015                 1020             


<210>  38
<211>  4988
<212>  DNA
<213>  Homo sapiens

<400>  38
attgaggagc agaaggagta gggtgcgggg gaggaggagg agcgccttta gtgctgcagc       60

agctgctgct ctgattggcc cggtggttca gctgcttccc tggaacaaaa ggtcaaagtg      120

gactgcagtg taaatgtaga gaagcagccg ataaaatagc attgcctgaa gaagtttgga      180

ggctgagagc agcagtagac tggccaactg cagagcaagt tgtttctcca gccgtgcggt      240

gcagcctcat gcccccaacc cagcttagcc actgtaagaa gacgttcact gtacagacga      300

ccaaacttgc cgtggaagag acagttgtga gattcccttg caaatttaca tacgagaatg      360

gcttgtgaaa tcatgcctct gcaaagtgct catgtacccc aagtcagcaa tgtgtctgca      420

accggagaac tcttagaaag aaccatccga tcagctgtag aacaacatct ttttgatgtt      480

aataactctg gaggtcaaag ttcagaggac tcagaatctg gaacactatc agcatcttct      540

gccacatctg ccagacagcg ccgccgccag tccaaggagc aggatgaagt tcgacatggg      600

agagacaagg gacttatcaa caaagaaaat actccttctg ggttcaacca ccttgatgat      660

tgtattttga atactcagga agtcgaaaag gtacacaaaa atacttttgg ttgtgctgga      720

gaaaggagca agcctaaacg tcagaaatcc agtactaaac tttctgagct tcatgacaat      780

caggacggtc ttgtgaatat ggaaagtctc aattccacac gatctcatga gagaactgga      840

cctgatgatt ttgaatggat gtctgatgaa aggaaaggaa atgaaaaaga tggtggacac      900

actcagcatt ttgagagccc cacaatgaag atccaggagc atcccagcct atctgacacc      960

aaacagcaga gaaatcaaga tgccggtgac caggaggaga gctttgtctc cgaagtgccc     1020

cagtcggacc tgactgcatt gtgtgatgaa aagaactggg aagagcctat ccctgctttc     1080

tcctcctggc agcgggagaa cagtgactct gatgaagccc acctctcgcc gcaggctggg     1140

cgcctgatcc gtcagctgct ggacgaagac agcgacccca tgctctctcc tcggttctac     1200

gcttatgggc agagcaggca atacctggat gacacagaag tgcctccttc cccaccaaac     1260

tcccattctt tcatgaggcg gcgaagctcc tctctggggt cctatgatga tgagcaagag     1320

gacctgacac ctgcccagct cacacgaagg attcagagcc ttaaaaagaa gatccggaag     1380

tttgaagata gattcgaaga agagaagaag tacagacctt cccacagtga caaagcagcc     1440

aatccggagg ttctgaaatg gacaaatgac cttgccaaat tccggagaca acttaaagaa     1500

tcaaaactaa agatatctga agaggaccta actcccagga tgcggcagcg aagcaacaca     1560

ctccccaaga gttttggttc ccaacttgag aaagaagatg agaagaagca agagctggtg     1620

gataaagcaa taaagcccag tgttgaagcc acattggaat ctattcagag gaagctccag     1680

gagaagcgag cggaaagcag ccgccctgag gacattaagg atatgaccaa agaccagatt     1740

gctaatgaga aagtggctct gcagaaagct ctgttatatt atgaaagcat tcatggacgg     1800

ccggtaacaa agaacgaacg gcaggtgatg aagccactat acgacaggta ccggctggtc     1860

aaacagatcc tctcccgagc taacaccata cccatcattg gttccccctc cagcaagcgg     1920

agaagccctt tgctgcagcc aattatcgag ggcgaaactg cttccttctt caaggagata     1980

aaggaagaag aggaggggtc agaagacgat agcaatgtga agccagactt catggtcact     2040

ctgaaaaccg atttcagtgc acgatgcttt ctggaccaat tcgaagatga cgctgatgga     2100

tttatttccc caatggatga taaaatacca tcaaaatgca gccaggacac agggctttca     2160

aatctccatg ctgcctcaat acctgaactc ctggaacacc tccaggaaat gagagaagaa     2220

aagaaaagga ttcgaaagaa acttcgggat tttgaagaca actttttcag acagaatgga     2280

agaaatgtcc agaaggaaga ccgcactcct atggctgaag aatacagtga atataagcac     2340

ataaaggcga aactgaggct cctggaggtg ctcatcagca agagagacac tgattccaag     2400

tccatgtgag gggcatggcc aagcacaggg ggctggcagc tgcggtgaga gtttactgtc     2460

cccagagaaa gtgcagctct ggaaggcagc cttggggctg gccctgcaaa gcatgcagcc     2520

cttctgcctc tagaccattt ggcatcggct cctgtttcca ttgcctgcct tagaaactgg     2580

ctggaagaag acaatgtgac ctgacttagg cattttgtaa ttggaaagtc aagactgcag     2640

tatgtgcaca tgcgcacgcg catgcacgca cacacacaca cagtagtgga gctttcctaa     2700

cactagcaga gattaatcac tacattagac aacactcatc tacagagaat atacactgtt     2760

cttccctgga taactgagaa acaagagacc attctctgtc taactgtgat aaaaacaagc     2820

tcaggacttt attctataga gcaaacttgc tgtggagggc catgctctcc ttggacccag     2880

ttaactgcaa acgtgcattg gagccctatt tgctgccgct gccattctag tgacctttcc     2940

acagagctgc gccttcctca cgtgtgtgaa aggttttccc cttcagccct caggtagatg     3000

gaagctgcat ctgcccacga tggcagtgca gtcatcatct tcaggatgtt tcttcaggac     3060

ttcctcagct gacaaggaat tttggtccct gcctaggacc gggtcatctg cagaggacag     3120

agagatggta agcagctgta tgaatgctga ttttaaaacc aggtcatggg agaagagcct     3180

ggagattctt tcctgaacac tgactgcact taccagtctg attttatcgt caaacaccaa     3240

gccaggctag catgctcatg gcaatctgtt tggggctgtt ttgttgtggc actagccaaa     3300

cataaagggg cttaagtcag cctgcataca gaggatcggg gagagaaggg gcctgtgttc     3360

tcagcctcct gagtacttac cagagtttaa tttttttaaa aaaaatctgc actaaaatcc     3420

ccaaactgac aggtaaatgt agccctcaga gctcagccca aggcagaatc taaatcacac     3480

tattttcgag atcatgtata aaaagaaaaa aaagaagtca tgctgtgtgg ccaattataa     3540

tttttttcaa agactttgtc acaaaactgt ctatattaga cattttggag ggaccaggaa     3600

atgtaagaca ccaaatcctc catctcttca gtgtgcctga tgtcacctca tgatttgctg     3660

ttactttttt aactcctgcg ccaaggacag tgggttctgt gtccaccttt gtgctttgcg     3720

aggccgagcc caggcatctg ctcgcctgcc acggctgacc agagaaggtg cttcaggagc     3780

tctgccttag acgacgtgtt acagtatgaa cacacagcag aggcaccctc gtatgttttg     3840

aaagttgcct tctgaaaggg cacagtttta aggaaaagaa aaagaatgta aaactatact     3900

gacccgtttt cagttttaaa gggtcgtgag aaactggctg gtccaatggg atttacagca     3960

acattttcca ttgctgaagt gaggtagcag ctctcttctg tcagctgaat gttaaggatg     4020

gggaaaaaga atgcctttaa gtttgctctt aatcgtatgg aagcttgagc tatgtgttgg     4080

aagtgccctg gttttaatcc atacacaaag acggtacata atcctacagg tttaaatgta     4140

cataaaaata tagtttggaa ttctttgctc tactgtttac attgcagatt gctataattt     4200

caaggagtga gattataaat aaaatgatgc actttaggat gtttcctatt tttgaaatct     4260

gaacatgaat cattcacatg accaaaaatt gtgttttttt aaaaatacat gtctagtctg     4320

tcctttaata gctctcttaa ataagctatg atattaatca gatcattacc agttagcttt     4380

taaagcacat ttgtttaaga ctatgttttt ggaaaaatac gctacagaat ttttttttaa     4440

gctacaaata aatgagatgc tactaattgt tttggaatct gttgtttctg ccaaaggtaa     4500

attaactaaa gatttattca ggaatcccca tttgaatttg tatgattcaa taaaagaaaa     4560

caccaagtaa gttatataaa ataaattgtg tatgagatgt tgtgttttcc tttgtaattt     4620

ccactaacta actaactaac ttatattctt catggaatgg agcccagaag aaatgagagg     4680

aagccctttt cacactagat cttatttgaa gaaatgtttg ttagtcagtc agtcagtggt     4740

ttctggctct gccgagggag atgtgttccc cagcaaccat ttctgcagcc cagaatctca     4800

aggcactaga ggcggtgtct taattaattg gcttcacaaa gacaaaatgc tctggactgg     4860

gatttttcct ttgctgtgtt gggaatatgt gtttattaat tagcacatgc caacaaaata     4920

aatgtcaaga gttatttcat aagtgtaagt aaacttaaga attaaagagt gcagacttat     4980

aattttca                                                              4988


<210>  39
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ala His Val Pro Gln Val 
1               5                   10                  15      


Ser Asn Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser 
            20                  25                  30          


Ala Val Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser 
        35                  40                  45              


Ser Glu Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser 
    50                  55                  60                  


Ala Arg Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His 
65                  70                  75                  80  


Gly Arg Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe 
                85                  90                  95      


Asn His Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val 
            100                 105                 110         


His Lys Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg 
        115                 120                 125             


Gln Lys Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly 
    130                 135                 140                 


Leu Val Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr 
145                 150                 155                 160 


Gly Pro Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu 
                165                 170                 175     


Lys Asp Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile 
            180                 185                 190         


Gln Glu His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp 
        195                 200                 205             


Ala Gly Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp 
    210                 215                 220                 


Leu Thr Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala 
225                 230                 235                 240 


Phe Ser Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu 
                245                 250                 255     


Ser Pro Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser 
            260                 265                 270         


Asp Pro Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln 
        275                 280                 285             


Tyr Leu Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser 
    290                 295                 300                 


Phe Met Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln 
305                 310                 315                 320 


Glu Asp Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys 
                325                 330                 335     


Lys Lys Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr 
            340                 345                 350         


Arg Pro Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp 
        355                 360                 365             


Thr Asn Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu 
    370                 375                 380                 


Lys Ile Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn 
385                 390                 395                 400 


Thr Leu Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys 
                405                 410                 415     


Lys Gln Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr 
            420                 425                 430         


Leu Glu Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser 
        435                 440                 445             


Arg Pro Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu 
    450                 455                 460                 


Lys Val Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly 
465                 470                 475                 480 


Arg Pro Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp 
                485                 490                 495     


Arg Tyr Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro 
            500                 505                 510         


Ile Ile Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu Gln Pro 
        515                 520                 525             


Ile Ile Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu Ile Lys Glu Glu 
    530                 535                 540                 


Glu Glu Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe Met Val 
545                 550                 555                 560 


Thr Leu Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln Phe Glu 
                565                 570                 575     


Asp Asp Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile Pro Ser 
            580                 585                 590         


Lys Cys Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala Ser Ile 
        595                 600                 605             


Pro Glu Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys Lys Arg 
    610                 615                 620                 


Ile Arg Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg Gln Asn 
625                 630                 635                 640 


Gly Arg Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu Glu Tyr 
                645                 650                 655     


Ser Glu Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu Val Leu 
            660                 665                 670         


Ile Ser Lys Arg Asp Thr Asp Ser Lys Ser Met 
        675                 680             


<210>  40
<211>  4946
<212>  DNA
<213>  Homo sapiens

<400>  40
attgaggagc agaaggagta gggtgcgggg gaggaggagg agcgccttta gtgctgcagc       60

agctgctgct ctgattggcc cggtggttca gctgcttccc tggaacaaaa ggtcaaagtg      120

gactgcagtg taaatgtaga gaagcagccg ataaaatagc attgcctgaa gaagtttgga      180

ggctgagagc agcagtagac tggccaactg cagagcaagt tgtttctcca gccgtgcggt      240

gcagcctcat gcccccaacc cagcttagcc actgtaagaa gacgttcact gtacagacga      300

ccaaacttgc cgtggaagag acagttgtga gattcccttg caaatttaca tacgagaatg      360

gcttgtgaaa tcatgcctct gcaaagttca caggaagatg aaagacctct gtcacctttc      420

tatttgagtg ctcatgtacc ccaagtcagc aatgtgtctg caaccggaga actcttagaa      480

agaaccatcc gatcagctgt agaacaacat ctttttgatg ttaataactc tggaggtcaa      540

agttcagagg actcagaatc tggaacacta tcagcatctt ctgccacatc tgccagacag      600

cgccgccgcc agtccaagga gcaggatgaa gttcgacatg ggagagacaa gggacttatc      660

aacaaagaaa atactccttc tgggttcaac caccttgatg attgtatttt gaatactcag      720

gaagtcgaaa aggtacacaa aaatactttt ggttgtgctg gagaaaggag caagcctaaa      780

cgtcagaaat ccagtactaa actttctgag cttcatgaca atcaggacgg tcttgtgaat      840

atggaaagtc tcaattccac acgatctcat gagagaactg gacctgatga ttttgaatgg      900

atgtctgatg aaaggaaagg aaatgaaaaa gatggtggac acactcagca ttttgagagc      960

cccacaatga agatccagga gcatcccagc ctatctgaca ccaaacagca gagaaatcaa     1020

gatgccggtg accaggagga gagctttgtc tccgaagtgc cccagtcgga cctgactgca     1080

ttgtgtgatg aaaagaactg ggaagagcct atccctgctt tctcctcctg gcagcgggag     1140

aacagtgact ctgatgaagc ccacctctcg ccgcaggctg ggcgcctgat ccgtcagctg     1200

ctggacgaag acagcgaccc catgctctct cctcggttct acgcttatgg gcagagcagg     1260

caatacctgg atgacacaga agtgcctcct tccccaccaa actcccattc tttcatgagg     1320

cggcgaagct cctctctggg gtcctatgat gatgagcaag aggacctgac acctgcccag     1380

ctcacacgaa ggattcagag ccttaaaaag aagatccgga agtttgaaga tagattcgaa     1440

gaagagaaga agtacagacc ttcccacagt gacaaagcag ccaatccgga ggttctgaaa     1500

tggacaaatg accttgccaa attccggaga caacttaaag aatcaaaact aaagatatct     1560

gaagaggacc taactcccag gatgcggcag cgaagcaaca cactccccaa gagttttggt     1620

tcccaacttg agaaagaaga tgagaagaag caagagctgg tggataaagc aataaagccc     1680

agtgttgaag ccacattgga atctattcag aggaagctcc aggagaagcg agcggaaagc     1740

agccgccctg aggacattaa ggatatgacc aaagaccaga ttgctaatga gaaagtggct     1800

ctgcagaaag ctctgttata ttatgaaagc attcatggac ggccggtaac aaagaacgaa     1860

cggcaggtga tgaagccact atacgacagg taccggctgg tcaaacagat cctctcccga     1920

gctaacacca tacccatcat tgaagaagag gaggggtcag aagacgatag caatgtgaag     1980

ccagacttca tggtcactct gaaaaccgat ttcagtgcac gatgctttct ggaccaattc     2040

gaagatgacg ctgatggatt tatttcccca atggatgata aaataccatc aaaatgcagc     2100

caggacacag ggctttcaaa tctccatgct gcctcaatac ctgaactcct ggaacacctc     2160

caggaaatga gagaagaaaa gaaaaggatt cgaaagaaac ttcgggattt tgaagacaac     2220

tttttcagac agaatggaag aaatgtccag aaggaagacc gcactcctat ggctgaagaa     2280

tacagtgaat ataagcacat aaaggcgaaa ctgaggctcc tggaggtgct catcagcaag     2340

agagacactg attccaagtc catgtgaggg gcatggccaa gcacaggggg ctggcagctg     2400

cggtgagagt ttactgtccc cagagaaagt gcagctctgg aaggcagcct tggggctggc     2460

cctgcaaagc atgcagccct tctgcctcta gaccatttgg catcggctcc tgtttccatt     2520

gcctgcctta gaaactggct ggaagaagac aatgtgacct gacttaggca ttttgtaatt     2580

ggaaagtcaa gactgcagta tgtgcacatg cgcacgcgca tgcacgcaca cacacacaca     2640

gtagtggagc tttcctaaca ctagcagaga ttaatcacta cattagacaa cactcatcta     2700

cagagaatat acactgttct tccctggata actgagaaac aagagaccat tctctgtcta     2760

actgtgataa aaacaagctc aggactttat tctatagagc aaacttgctg tggagggcca     2820

tgctctcctt ggacccagtt aactgcaaac gtgcattgga gccctatttg ctgccgctgc     2880

cattctagtg acctttccac agagctgcgc cttcctcacg tgtgtgaaag gttttcccct     2940

tcagccctca ggtagatgga agctgcatct gcccacgatg gcagtgcagt catcatcttc     3000

aggatgtttc ttcaggactt cctcagctga caaggaattt tggtccctgc ctaggaccgg     3060

gtcatctgca gaggacagag agatggtaag cagctgtatg aatgctgatt ttaaaaccag     3120

gtcatgggag aagagcctgg agattctttc ctgaacactg actgcactta ccagtctgat     3180

tttatcgtca aacaccaagc caggctagca tgctcatggc aatctgtttg gggctgtttt     3240

gttgtggcac tagccaaaca taaaggggct taagtcagcc tgcatacaga ggatcgggga     3300

gagaaggggc ctgtgttctc agcctcctga gtacttacca gagtttaatt tttttaaaaa     3360

aaatctgcac taaaatcccc aaactgacag gtaaatgtag ccctcagagc tcagcccaag     3420

gcagaatcta aatcacacta ttttcgagat catgtataaa aagaaaaaaa agaagtcatg     3480

ctgtgtggcc aattataatt tttttcaaag actttgtcac aaaactgtct atattagaca     3540

ttttggaggg accaggaaat gtaagacacc aaatcctcca tctcttcagt gtgcctgatg     3600

tcacctcatg atttgctgtt acttttttaa ctcctgcgcc aaggacagtg ggttctgtgt     3660

ccacctttgt gctttgcgag gccgagccca ggcatctgct cgcctgccac ggctgaccag     3720

agaaggtgct tcaggagctc tgccttagac gacgtgttac agtatgaaca cacagcagag     3780

gcaccctcgt atgttttgaa agttgccttc tgaaagggca cagttttaag gaaaagaaaa     3840

agaatgtaaa actatactga cccgttttca gttttaaagg gtcgtgagaa actggctggt     3900

ccaatgggat ttacagcaac attttccatt gctgaagtga ggtagcagct ctcttctgtc     3960

agctgaatgt taaggatggg gaaaaagaat gcctttaagt ttgctcttaa tcgtatggaa     4020

gcttgagcta tgtgttggaa gtgccctggt tttaatccat acacaaagac ggtacataat     4080

cctacaggtt taaatgtaca taaaaatata gtttggaatt ctttgctcta ctgtttacat     4140

tgcagattgc tataatttca aggagtgaga ttataaataa aatgatgcac tttaggatgt     4200

ttcctatttt tgaaatctga acatgaatca ttcacatgac caaaaattgt gtttttttaa     4260

aaatacatgt ctagtctgtc ctttaatagc tctcttaaat aagctatgat attaatcaga     4320

tcattaccag ttagctttta aagcacattt gtttaagact atgtttttgg aaaaatacgc     4380

tacagaattt ttttttaagc tacaaataaa tgagatgcta ctaattgttt tggaatctgt     4440

tgtttctgcc aaaggtaaat taactaaaga tttattcagg aatccccatt tgaatttgta     4500

tgattcaata aaagaaaaca ccaagtaagt tatataaaat aaattgtgta tgagatgttg     4560

tgttttcctt tgtaatttcc actaactaac taactaactt atattcttca tggaatggag     4620

cccagaagaa atgagaggaa gcccttttca cactagatct tatttgaaga aatgtttgtt     4680

agtcagtcag tcagtggttt ctggctctgc cgagggagat gtgttcccca gcaaccattt     4740

ctgcagccca gaatctcaag gcactagagg cggtgtctta attaattggc ttcacaaaga     4800

caaaatgctc tggactggga tttttccttt gctgtgttgg gaatatgtgt ttattaatta     4860

gcacatgcca acaaaataaa tgtcaagagt tatttcataa gtgtaagtaa acttaagaat     4920

taaagagtgc agacttataa ttttca                                          4946


<210>  41
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ser Gln Glu Asp Glu Arg 
1               5                   10                  15      


Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gln Val Ser Asn 
            20                  25                  30          


Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser Ala Val 
        35                  40                  45              


Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser Ser Glu 
    50                  55                  60                  


Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg 
65                  70                  75                  80  


Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His Gly Arg 
                85                  90                  95      


Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His 
            100                 105                 110         


Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val His Lys 
        115                 120                 125             


Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gln Lys 
    130                 135                 140                 


Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val 
145                 150                 155                 160 


Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro 
                165                 170                 175     


Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp 
            180                 185                 190         


Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile Gln Glu 
        195                 200                 205             


His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp Ala Gly 
    210                 215                 220                 


Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp Leu Thr 
225                 230                 235                 240 


Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala Phe Ser 
                245                 250                 255     


Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro 
            260                 265                 270         


Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser Asp Pro 
        275                 280                 285             


Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln Tyr Leu 
    290                 295                 300                 


Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met 
305                 310                 315                 320 


Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln Glu Asp 
                325                 330                 335     


Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys Lys Lys 
            340                 345                 350         


Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro 
        355                 360                 365             


Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn 
    370                 375                 380                 


Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu Lys Ile 
385                 390                 395                 400 


Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn Thr Leu 
                405                 410                 415     


Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys Lys Gln 
            420                 425                 430         


Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr Leu Glu 
        435                 440                 445             


Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser Arg Pro 
    450                 455                 460                 


Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu Lys Val 
465                 470                 475                 480 


Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly Arg Pro 
                485                 490                 495     


Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp Arg Tyr 
            500                 505                 510         


Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro Ile Ile 
        515                 520                 525             


Glu Glu Glu Glu Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe 
    530                 535                 540                 


Met Val Thr Leu Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln 
545                 550                 555                 560 


Phe Glu Asp Asp Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile 
                565                 570                 575     


Pro Ser Lys Cys Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala 
            580                 585                 590         


Ser Ile Pro Glu Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys 
        595                 600                 605             


Lys Arg Ile Arg Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg 
    610                 615                 620                 


Gln Asn Gly Arg Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu 
625                 630                 635                 640 


Glu Tyr Ser Glu Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu 
                645                 650                 655     


Val Leu Ile Ser Lys Arg Asp Thr Asp Ser Lys Ser Met 
            660                 665                 


<210>  42
<211>  4946
<212>  DNA
<213>  Homo sapiens

<400>  42
attgaggagc agaaggagta gggtgcgggg gaggaggagg agcgccttta gtgctgcagc       60

agctgctgct ctgattggcc cggtggttca gctgcttccc tggaacaaaa ggtcaaagtg      120

gactgcagtg taaatgtaga gaagcagccg ataaaatagc attgcctgaa gaagtttgga      180

ggctgagagc agcagtagac tggccaactg cagagcaagt tgtttctcca gccgtgcggt      240

gcagcctcat gcccccaacc cagcttagcc actgtaagaa gacgttcact gtacagacga      300

ccaaacttgc cgtggaagag acagttgtga gattcccttg caaatttaca tacgagaatg      360

gcttgtgaaa tcatgcctct gcaaagactc ttagaaagaa ccatccgatc agctgtagaa      420

caacatcttt ttgatgttaa taactctgga ggtcaaagtt cagaggactc agaatctgga      480

acactatcag catcttctgc cacatctgcc agacagcgcc gccgccagtc caaggagcag      540

gatgaagttc gacatgggag agacaaggga cttatcaaca aagaaaatac tccttctggg      600

ttcaaccacc ttgatgattg tattttgaat actcaggaag tcgaaaaggt acacaaaaat      660

acttttggtt gtgctggaga aaggagcaag cctaaacgtc agaaatccag tactaaactt      720

tctgagcttc atgacaatca ggacggtctt gtgaatatgg aaagtctcaa ttccacacga      780

tctcatgaga gaactggacc tgatgatttt gaatggatgt ctgatgaaag gaaaggaaat      840

gaaaaagatg gtggacacac tcagcatttt gagagcccca caatgaagat ccaggagcat      900

cccagcctat ctgacaccaa acagcagaga aatcaagatg ccggtgacca ggaggagagc      960

tttgtctccg aagtgcccca gtcggacctg actgcattgt gtgatgaaaa gaactgggaa     1020

gagcctatcc ctgctttctc ctcctggcag cgggagaaca gtgactctga tgaagcccac     1080

ctctcgccgc aggctgggcg cctgatccgt cagctgctgg acgaagacag cgaccccatg     1140

ctctctcctc ggttctacgc ttatgggcag agcaggcaat acctggatga cacagaagtg     1200

cctccttccc caccaaactc ccattctttc atgaggcggc gaagctcctc tctggggtcc     1260

tatgatgatg agcaagagga cctgacacct gcccagctca cacgaaggat tcagagcctt     1320

aaaaagaaga tccggaagtt tgaagataga ttcgaagaag agaagaagta cagaccttcc     1380

cacagtgaca aagcagccaa tccggaggtt ctgaaatgga caaatgacct tgccaaattc     1440

cggagacaac ttaaagaatc aaaactaaag atatctgaag aggacctaac tcccaggatg     1500

cggcagcgaa gcaacacact ccccaagagt tttggttccc aacttgagaa agaagatgag     1560

aagaagcaag agctggtgga taaagcaata aagcccagtg ttgaagccac attggaatct     1620

attcagagga agctccagga gaagcgagcg gaaagcagcc gccctgagga cattaaggat     1680

atgaccaaag accagattgc taatgagaaa gtggctctgc agaaagctct gttatattat     1740

gaaagcattc atggacggcc ggtaacaaag aacgaacggc aggtgatgaa gccactatac     1800

gacaggtacc ggctggtcaa acagatcctc tcccgagcta acaccatacc catcattggt     1860

tccccctcca gcaagcggag aagccctttg ctgcagccaa ttatcgaggg cgaaactgct     1920

tccttcttca aggagataaa ggaagaagag gaggggtcag aagacgatag caatgtgaag     1980

ccagacttca tggtcactct gaaaaccgat ttcagtgcac gatgctttct ggaccaattc     2040

gaagatgacg ctgatggatt tatttcccca atggatgata aaataccatc aaaatgcagc     2100

caggacacag ggctttcaaa tctccatgct gcctcaatac ctgaactcct ggaacacctc     2160

caggaaatga gagaagaaaa gaaaaggatt cgaaagaaac ttcgggattt tgaagacaac     2220

tttttcagac agaatggaag aaatgtccag aaggaagacc gcactcctat ggctgaagaa     2280

tacagtgaat ataagcacat aaaggcgaaa ctgaggctcc tggaggtgct catcagcaag     2340

agagacactg attccaagtc catgtgaggg gcatggccaa gcacaggggg ctggcagctg     2400

cggtgagagt ttactgtccc cagagaaagt gcagctctgg aaggcagcct tggggctggc     2460

cctgcaaagc atgcagccct tctgcctcta gaccatttgg catcggctcc tgtttccatt     2520

gcctgcctta gaaactggct ggaagaagac aatgtgacct gacttaggca ttttgtaatt     2580

ggaaagtcaa gactgcagta tgtgcacatg cgcacgcgca tgcacgcaca cacacacaca     2640

gtagtggagc tttcctaaca ctagcagaga ttaatcacta cattagacaa cactcatcta     2700

cagagaatat acactgttct tccctggata actgagaaac aagagaccat tctctgtcta     2760

actgtgataa aaacaagctc aggactttat tctatagagc aaacttgctg tggagggcca     2820

tgctctcctt ggacccagtt aactgcaaac gtgcattgga gccctatttg ctgccgctgc     2880

cattctagtg acctttccac agagctgcgc cttcctcacg tgtgtgaaag gttttcccct     2940

tcagccctca ggtagatgga agctgcatct gcccacgatg gcagtgcagt catcatcttc     3000

aggatgtttc ttcaggactt cctcagctga caaggaattt tggtccctgc ctaggaccgg     3060

gtcatctgca gaggacagag agatggtaag cagctgtatg aatgctgatt ttaaaaccag     3120

gtcatgggag aagagcctgg agattctttc ctgaacactg actgcactta ccagtctgat     3180

tttatcgtca aacaccaagc caggctagca tgctcatggc aatctgtttg gggctgtttt     3240

gttgtggcac tagccaaaca taaaggggct taagtcagcc tgcatacaga ggatcgggga     3300

gagaaggggc ctgtgttctc agcctcctga gtacttacca gagtttaatt tttttaaaaa     3360

aaatctgcac taaaatcccc aaactgacag gtaaatgtag ccctcagagc tcagcccaag     3420

gcagaatcta aatcacacta ttttcgagat catgtataaa aagaaaaaaa agaagtcatg     3480

ctgtgtggcc aattataatt tttttcaaag actttgtcac aaaactgtct atattagaca     3540

ttttggaggg accaggaaat gtaagacacc aaatcctcca tctcttcagt gtgcctgatg     3600

tcacctcatg atttgctgtt acttttttaa ctcctgcgcc aaggacagtg ggttctgtgt     3660

ccacctttgt gctttgcgag gccgagccca ggcatctgct cgcctgccac ggctgaccag     3720

agaaggtgct tcaggagctc tgccttagac gacgtgttac agtatgaaca cacagcagag     3780

gcaccctcgt atgttttgaa agttgccttc tgaaagggca cagttttaag gaaaagaaaa     3840

agaatgtaaa actatactga cccgttttca gttttaaagg gtcgtgagaa actggctggt     3900

ccaatgggat ttacagcaac attttccatt gctgaagtga ggtagcagct ctcttctgtc     3960

agctgaatgt taaggatggg gaaaaagaat gcctttaagt ttgctcttaa tcgtatggaa     4020

gcttgagcta tgtgttggaa gtgccctggt tttaatccat acacaaagac ggtacataat     4080

cctacaggtt taaatgtaca taaaaatata gtttggaatt ctttgctcta ctgtttacat     4140

tgcagattgc tataatttca aggagtgaga ttataaataa aatgatgcac tttaggatgt     4200

ttcctatttt tgaaatctga acatgaatca ttcacatgac caaaaattgt gtttttttaa     4260

aaatacatgt ctagtctgtc ctttaatagc tctcttaaat aagctatgat attaatcaga     4320

tcattaccag ttagctttta aagcacattt gtttaagact atgtttttgg aaaaatacgc     4380

tacagaattt ttttttaagc tacaaataaa tgagatgcta ctaattgttt tggaatctgt     4440

tgtttctgcc aaaggtaaat taactaaaga tttattcagg aatccccatt tgaatttgta     4500

tgattcaata aaagaaaaca ccaagtaagt tatataaaat aaattgtgta tgagatgttg     4560

tgttttcctt tgtaatttcc actaactaac taactaactt atattcttca tggaatggag     4620

cccagaagaa atgagaggaa gcccttttca cactagatct tatttgaaga aatgtttgtt     4680

agtcagtcag tcagtggttt ctggctctgc cgagggagat gtgttcccca gcaaccattt     4740

ctgcagccca gaatctcaag gcactagagg cggtgtctta attaattggc ttcacaaaga     4800

caaaatgctc tggactggga tttttccttt gctgtgttgg gaatatgtgt ttattaatta     4860

gcacatgcca acaaaataaa tgtcaagagt tatttcataa gtgtaagtaa acttaagaat     4920

taaagagtgc agacttataa ttttca                                          4946


<210>  43
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Cys Glu Ile Met Pro Leu Gln Arg Leu Leu Glu Arg Thr Ile 
1               5                   10                  15      


Arg Ser Ala Val Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly 
            20                  25                  30          


Gln Ser Ser Glu Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala 
        35                  40                  45              


Thr Ser Ala Arg Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val 
    50                  55                  60                  


Arg His Gly Arg Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser 
65                  70                  75                  80  


Gly Phe Asn His Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu 
                85                  90                  95      


Lys Val His Lys Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro 
            100                 105                 110         


Lys Arg Gln Lys Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln 
        115                 120                 125             


Asp Gly Leu Val Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu 
    130                 135                 140                 


Arg Thr Gly Pro Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly 
145                 150                 155                 160 


Asn Glu Lys Asp Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met 
                165                 170                 175     


Lys Ile Gln Glu His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn 
            180                 185                 190         


Gln Asp Ala Gly Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln 
        195                 200                 205             


Ser Asp Leu Thr Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile 
    210                 215                 220                 


Pro Ala Phe Ser Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala 
225                 230                 235                 240 


His Leu Ser Pro Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu 
                245                 250                 255     


Asp Ser Asp Pro Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser 
            260                 265                 270         


Arg Gln Tyr Leu Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser 
        275                 280                 285             


His Ser Phe Met Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp 
    290                 295                 300                 


Glu Gln Glu Asp Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser 
305                 310                 315                 320 


Leu Lys Lys Lys Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys 
                325                 330                 335     


Lys Tyr Arg Pro Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu 
            340                 345                 350         


Lys Trp Thr Asn Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser 
        355                 360                 365             


Lys Leu Lys Ile Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg 
    370                 375                 380                 


Ser Asn Thr Leu Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp 
385                 390                 395                 400 


Glu Lys Lys Gln Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu 
                405                 410                 415     


Ala Thr Leu Glu Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu 
            420                 425                 430         


Ser Ser Arg Pro Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala 
        435                 440                 445             


Asn Glu Lys Val Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile 
    450                 455                 460                 


His Gly Arg Pro Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu 
465                 470                 475                 480 


Tyr Asp Arg Tyr Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr 
                485                 490                 495     


Ile Pro Ile Ile Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu 
            500                 505                 510         


Gln Pro Ile Ile Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu Ile Lys 
        515                 520                 525             


Glu Glu Glu Glu Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe 
    530                 535                 540                 


Met Val Thr Leu Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln 
545                 550                 555                 560 


Phe Glu Asp Asp Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile 
                565                 570                 575     


Pro Ser Lys Cys Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala 
            580                 585                 590         


Ser Ile Pro Glu Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys 
        595                 600                 605             


Lys Arg Ile Arg Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg 
    610                 615                 620                 


Gln Asn Gly Arg Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu 
625                 630                 635                 640 


Glu Tyr Ser Glu Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu 
                645                 650                 655     


Val Leu Ile Ser Lys Arg Asp Thr Asp Ser Lys Ser Met 
            660                 665                 


<210>  44
<211>  9802
<212>  DNA
<213>  Homo sapiens

<400>  44
aagaaaccgg ccaggtgtgg cctaggcgcc cagtgccagc ggggaggaga ctcgctccgc       60

cgccgaccaa caccaacacc cagctccgac gcagctcctc tgcgcccttg ccgccctccg      120

agccacagct ttcctcccgc tcctgccccc ggcccgtcgc cgtctccgcg ctcgcagcgg      180

cctcgggagg gcccaggtag cgagcagcga cctcgcgagc cttccgcact cccgcccggt      240

tccccggccg tccgcctatc cttggccccc tccgctttct ccgcgccggc ccgcctcgct      300

tatgcctcgg cgctgagccg ctctcccgat tgcccgccga catgagctgc aacggaggct      360

cccacccgcg gatcaacact ctgggccgca tgatccgcgc cgagtctggc ccggacctgc      420

gctacgaggt gaccagcggc ggcgggggca ccagcaggat gtactattct cggcgcggcg      480

tgatcaccga ccagaactcg gacggctact gtcaaaccgg cacgatgtcc aggcaccaga      540

accagaacac catccaggag ctgctgcaga actgctccga ctgcttgatg cgagcagagc      600

tcatcgtgca gcctgaattg aagtatggag atggaataca actgactcgg agtcgagaat      660

tggatgagtg ttttgcccag gccaatgacc aaatggaaat cctcgacagc ttgatcagag      720

agatgcggca gatgggccag ccctgtgatg cttaccagaa aaggcttctt cagctccaag      780

agcaaatgcg agccctttat aaagccatca gtgtccctcg agtccgcagg gccagctcca      840

agggtggtgg aggctacact tgtcagagtg gctctggctg ggatgagttc accaaacatg      900

tcaccagtga atgtttgggg tggatgaggc agcaaagggc ggagatggac atggtggcct      960

ggggtgtgga cctggcctca gtggagcagc acattaacag ccaccggggc atccacaact     1020

ccatcggcga ctatcgctgg cagctggaca aaatcaaagc cgacctgcgc gagaaatctg     1080

cgatctacca gttggaggag gagtatgaaa acctgctgaa agcgtccttt gagaggatgg     1140

atcacctgcg acagctgcag aacatcattc aggccacgtc cagggagatc atgtggatca     1200

atgactgcga ggaggaggag ctgctgtacg actggagcga caagaacacc aacatcgctc     1260

agaaacagga ggccttctcc atacgcatga gtcaactgga agttaaagaa aaagagctca     1320

ataagctgaa acaagaaagt gaccaacttg tcctcaatca gcatccagct tcagacaaaa     1380

ttgaggccta tatggacact ctgcagacgc agtggagttg gattcttcag atcaccaagt     1440

gcattgatgt tcatctgaaa gaaaatgctg cctactttca gttttttgaa gaggcgcagt     1500

ctactgaagc atacctgaag gggctccagg actccatcag gaagaagtac ccctgcgaca     1560

agaacatgcc cctgcagcac ctgctggaac agatcaagga gctggagaaa gaacgagaga     1620

aaatccttga atacaagcgt caggtgcaga acttggtaaa caagtctaag aagattgtac     1680

agctgaagcc tcgtaaccca gactacagaa gcaataaacc cattattctc agagctctct     1740

gtgactacaa acaagatcag aaaatcgtgc ataaggggga tgagtgtatc ctgaaggaca     1800

acaacgagcg cagcaagtgg tacgtgacgg gcccgggagg cgttgacatg cttgttccct     1860

ctgtggggct gatcatccct cctccgaacc cactggccgt ggacctctct tgcaagattg     1920

agcagtacta cgaagccatc ttggctctgt ggaaccagct ctacatcaac atgaagagcc     1980

tggtgtcctg gcactactgc atgattgaca tagagaagat cagggccatg acaatcgcca     2040

agctgaaaac aatgcggcag gaagattaca tgaagacgat agccgacctt gagttacatt     2100

accaagagtt catcagaaat agccaaggct cagagatgtt tggagatgat gacaagcgga     2160

aaatacagtc tcagttcacc gatgcccaga agcattacca gaccctggtc attcagctcc     2220

ctggctatcc ccagcaccag acagtgacca caactgaaat cactcatcat ggaacctgcc     2280

aagatgtcaa ccataataaa gtaattgaaa ccaacagaga aaatgacaag caagaaacat     2340

ggatgctgat ggagctgcag aagattcgca ggcagataga gcactgcgag ggcaggatga     2400

ctctcaaaaa cctccctcta gcagaccagg gatcttctca ccacatcaca gtgaaaatta     2460

acgagcttaa gagtgtgcag aatgattcac aagcaattgc tgaggttctc aaccagctta     2520

aagatatgct tgccaacttc agaggttctg aaaagtactg ctatttacag aatgaagtat     2580

ttggactatt tcagaaactg gaaaatatca atggtgttac agatggctac ttaaatagct     2640

tatgcacagt aagggcactg ctccaggcta ttctccaaac agaagacatg ttaaaggttt     2700

atgaagccag gctcactgag gaggaaactg tctgcctgga cctggataaa gtggaagctt     2760

accgctgtgg actgaagaaa ataaaaaatg acttgaactt gaagaagtcg ttgttggcca     2820

ctatgaagac agaactacag aaagcccagc agatccactc tcagacttca cagcagtatc     2880

cactttatga tctggacttg ggcaagttcg gtgaaaaagt cacacagctg acagaccgct     2940

ggcaaaggat agataaacag atcgacttta ggttatggga cctggagaaa caaatcaagc     3000

aattgaggaa ttatcgtgat aactatcagg ctttctgcaa gtggctctat gatgctaaac     3060

gccgccagga ttccttagaa tccatgaaat ttggagattc caacacagtc atgcggtttt     3120

tgaatgagca gaagaacttg cacagtgaaa tatctggcaa acgagacaaa tcagaggaag     3180

tacaaaaaat tgctgaactt tgcgccaatt caattaagga ttatgagctc cagctggcct     3240

catacacctc aggactggaa actctgctga acatacctat caagaggacc atgattcagt     3300

ccccttctgg ggtgattctg caagaggctg cagatgttca tgctcggtac attgaactac     3360

ttacaagatc tggagactat tacaggttct taagtgagat gctgaagagt ttggaagatc     3420

tgaagctgaa aaataccaag atcgaagttt tggaagagga gctcagactg gcccgagatg     3480

ccaactcgga aaactgtaat aagaacaaat tcctggatca gaacctgcag aaataccagg     3540

cagagtgttc ccagttcaaa gcgaagcttg cgagcctgga ggagctgaag agacaggctg     3600

agctggatgg gaagtcggct aagcaaaatc tagacaagtg ctacggccaa ataaaagaac     3660

tcaatgagaa gatcacccga ctgacttatg agattgaaga tgaaaagaga agaagaaaat     3720

ctgtggaaga cagatttgac caacagaaga atgactatga ccaactgcag aaagcaaggc     3780

aatgtgaaaa ggagaacctt ggttggcaga aattagagtc tgagaaagcc atcaaggaga     3840

aggagtacga gattgaaagg ttgagggttc tactgcagga agaaggcacc cggaagagag     3900

aatatgaaaa tgagctggca aaggtaagaa accactataa tgaggagatg agtaatttaa     3960

ggaacaagta tgaaacagag attaacatta cgaagaccac catcaaggag atatccatgc     4020

aaaaagagga tgattccaaa aatcttagaa accagcttga tagactttca agggaaaatc     4080

gagatctgaa ggatgaaatt gtcaggctca atgacagcat cttgcaggcc actgagcagc     4140

gaaggcgagc tgaagaaaac gcccttcagc aaaaggcctg tggctctgag ataatgcaga     4200

agaagcagca tctggagata gaactgaagc aggtcatgca gcagcgctct gaggacaatg     4260

cccggcacaa gcagtccctg gaggaggctg ccaagaccat tcaggacaaa aataaggaga     4320

tcgagagact caaagctgag tttcaggagg aggccaagcg ccgctgggaa tatgaaaatg     4380

aactgagtaa ggtaagaaac aattatgatg aggagatcat tagcttaaaa aatcagtttg     4440

agaccgagat caacatcacc aagaccacca tccaccagct caccatgcag aaggaagagg     4500

ataccagtgg ctaccgggct cagatagaca atctcacccg agaaaacagg agcttatctg     4560

aagaaataaa gaggctgaag aacactctaa cccagaccac agagaatctc aggagggtgg     4620

aagaagacat ccaacagcaa aaggccactg gctctgaggt gtctcagagg aaacagcagc     4680

tggaggttga gctgagacaa gtcactcaga tgcgaacaga ggagagcgta agatataagc     4740

aatctcttga tgatgctgcc aaaaccatcc aggataaaaa caaggagata gaaaggttaa     4800

aacaactgat cgacaaagaa acaaatgacc ggaaatgcct ggaagatgaa aacgcgagat     4860

tacaaagggt ccagtatgac ctgcagaaag caaacagtag tgcgacggag acaataaaca     4920

aactgaaggt tcaggagcaa gaactgacac gcctgaggat cgactatgaa agggtttccc     4980

aggagaggac tgtgaaggac caggatatca cgcggttcca gaactctctg aaagagctgc     5040

agctgcagaa gcagaaggtg gaagaggagc tgaatcggct gaagaggacc gcgtcagaag     5100

actcctgcaa gaggaagaag ctggaggaag agctggaagg catgaggagg tcgctgaagg     5160

agcaagccat caaaatcacc aacctgaccc agcagctgga gcaggcatcc attgttaaga     5220

agaggagtga ggatgacctc cggcagcaga gggacgtgct ggatggccac ctgagggaaa     5280

agcagaggac ccaggaagag ctgaggaggc tctcttctga ggtcgaggcc ctgaggcggc     5340

agttactcca ggaacaggaa agtgtcaaac aagctcactt gaggaatgag catttccaga     5400

aggcgataga agataaaagc agaagcttaa atgaaagcaa aatagaaatt gagaggctgc     5460

agtctctcac agagaacctg accaaggagc acttgatgtt agaagaagaa ctgcggaacc     5520

tgaggctgga gtacgatgac ctgaggagag gacgaagcga agcggacagt gataaaaatg     5580

caaccatctt ggaactaagg agccagctgc agatcagcaa caaccggacc ctggaactgc     5640

aggggctgat taatgattta cagagagaga gggaaaattt gagacaggaa attgagaaat     5700

tccaaaagca ggctttagag gcatctaata ggattcagga atcaaagaat cagtgtactc     5760

aggtggtaca ggaaagagag agccttctgg tgaaaatcaa agtcctggag caagacaagg     5820

caaggctgca gaggctggag gatgagctga atcgtgcaaa atcaactcta gaggcagaaa     5880

ccagggtgaa acagcgcctg gagtgtgaga aacagcaaat tcagaatgac ctgaatcagt     5940

ggaagactca atattcccgc aaggaggagg ctattaggaa gatagaatcg gaaagagaaa     6000

agagtgagag agagaagaac agtcttagga gtgagatcga aagactccaa gcagagatca     6060

agagaattga agagaggtgc aggcgtaagc tggaggattc taccagggag acacagtcac     6120

agttagaaac agaacgctcc cgatatcaga gggagattga taaactcaga cagcgcccat     6180

atgggtccca tcgagagacc cagactgagt gtgagtggac cgttgacacc tccaagctgg     6240

tgtttgatgg gctgaggaag aaggtgacag caatgcagct ctatgagtgt cagctgatcg     6300

acaaaacaac cttggacaaa ctattgaagg ggaagaagtc agtggaagaa gttgcttctg     6360

aaatccagcc attccttcgg ggtgcaggat ctatcgctgg agcatctgct tctcctaagg     6420

aaaaatactc tttggtagag gccaagagaa agaaattaat cagcccagaa tccacagtca     6480

tgcttctgga ggcccaggca gctacaggtg gtataattga tccccatcgg aatgagaagc     6540

tgactgtcga cagtgccata gctcgggacc tcattgactt cgatgaccgt cagcagatat     6600

atgcagcaga aaaagctatc actggttttg atgatccatt ttcaggcaag acagtatctg     6660

tttcagaagc catcaagaaa aatttgattg atagagaaac cggaatgcgc ctgctggaag     6720

cccagattgc ttcagggggt gtagtagacc ctgtgaacag tgtctttttg ccaaaagatg     6780

tcgccttggc ccgggggctg attgatagag atttgtatcg atccctgaat gatccccgag     6840

atagtcagaa aaactttgtg gatccagtca ccaaaaagaa ggtcagttac gtgcagctga     6900

aggaacggtg cagaatcgaa ccacatactg gtctgctctt gctttcagta cagaagagaa     6960

gcatgtcctt ccaaggaatc agacaacctg tgaccgtcac tgagctagta gattctggta     7020

tattgagacc gtccactgtc aatgaactgg aatctggtca gatttcttat gacgaggttg     7080

gtgagagaat taaggacttc ctccagggtt caagctgcat agcaggcata tacaatgaga     7140

ccacaaaaca gaagcttggc atttatgagg ccatgaaaat tggcttagtc cgacctggta     7200

ctgctctgga gttgctggaa gcccaagcag ctactggctt tatagtggat cctgttagca     7260

acttgaggtt accagtggag gaagcctaca agagaggtct ggtgggcatt gagttcaaag     7320

agaagctcct gtctgcagaa cgagctgtca ctgggtataa tgatcctgaa acaggaaaca     7380

tcatctcttt gttccaagcc atgaataagg aactcatcga aaagggccac ggtattcgct     7440

tattagaagc acagatcgca accgggggga tcattgaccc aaaggagagc catcgtttac     7500

cagttgacat agcatataag aggggctatt tcaatgagga actcagtgag attctctcag     7560

atccaagtga tgataccaaa ggattttttg accccaacac tgaagaaaat cttacctatc     7620

tgcaactaaa agaaagatgc attaaggatg aggaaacagg gctctgtctt ctgcctctga     7680

aagaaaagaa gaaacaggtg cagacatcac aaaagaatac cctcaggaag cgtagagtgg     7740

tcatagttga cccagaaacc aataaagaaa tgtctgttca ggaggcctac aagaagggcc     7800

taattgatta tgaaaccttc aaagaactgt gtgagcagga atgtgaatgg gaagaaataa     7860

ccatcacggg atcagatggc tccaccaggg tggtcctggt agatagaaag acaggcagtc     7920

agtatgatat tcaagatgct attgacaagg gccttgttga caggaagttc tttgatcagt     7980

accgatccgg cagcctcagc ctcactcaat ttgctgacat gatctccttg aaaaatggtg     8040

tcggcaccag cagcagcatg ggcagtggtg tcagcgatga tgtttttagc agctcccgac     8100

atgaatcagt aagtaagatt tccaccatat ccagcgtcag gaatttaacc ataaggagca     8160

gctctttttc agacaccctg gaagaatcga gccccattgc agccatcttt gacacagaaa     8220

acctggagaa aatctccatt acagaaggta tagagcgggg catcgttgac agcatcacgg     8280

gtcagaggct tctggaggct caggcctgca caggtggcat catccaccca accacgggcc     8340

agaagctgtc acttcaggac gcagtctccc agggtgtgat tgaccaagac atggccacca     8400

ggctgaagcc tgctcagaaa gccttcatag gcttcgaggg tgtgaaggga aagaagaaga     8460

tgtcagcagc agaggcagtg aaagaaaaat ggctcccgta tgaggctggc cagcgcttcc     8520

tggagttcca gtacctcacg ggaggtcttg ttgacccgga agtgcatggg aggataagca     8580

ccgaagaagc catccggaag gggttcatag atggccgcgc cgcacagagg ctgcaagaca     8640

ccagcagcta tgccaaaatc ctgacctgcc ccaaaaccaa attaaaaata tcctataagg     8700

atgccataaa tcgctccatg gtagaagata tcactgggct gcgccttctg gaagccgcct     8760

ccgtgtcgtc caagggctta cccagccctt acaacatgtc ttcggctccg gggtcccgct     8820

ccggctcccg ctcgggatct cgctccggat ctcgctccgg gtcccgcagt gggtcccgga     8880

gaggaagctt tgacgccaca gggaattctt cctactctta ttcctactca tttagcagta     8940

gttctattgg gcactagtag tcagttggga gtggttgcta taccttgact tcatttatat     9000

gaatttccac tttattaaat aatagaaaag aaaatcccgg tgcttgcagt agagtgatag     9060

gacattctat gcttacagaa aatatagcca tgattgaaat caaatagtaa aggctgttct     9120

ggctttttat cttcttagct catcttaaat aagcagtaca cttggatgca gtgcgtctga     9180

agtgctaatc agttgtaaca atagcacaaa tcgaacttag gatttgtttc ttctcttctg     9240

tgtttcgatt tttgatcaat tctttaattt tggaagccta taatacagtt ttctattctt     9300

ggagataaaa attaaatgga tcactgatat tttagtcatt ctgcttctca tctaaatatt     9360

tccatattct gtattaggag aaaattaccc tcccagcacc agcccccctc tcaaaccccc     9420

aacccaaaac caagcatttt ggaatgagtc tcctttagtt tcagagtgtg gattgtataa     9480

cccatatact cttcgatgta cttgtttggt ttggtattaa tttgactgtg catgacagcg     9540

gcaatctttt ctttggtcaa agttttctgt ttattttgct tgtcatattc gatgtacttt     9600

aaggtgtctt tatgaagttt gctattctgg caataaactt ttagactttt gaagtgtttg     9660

tgttttaatt taatatgttt ataagcatgt ataaacattt agcatatttt tatcataggt     9720

ctaaaaatat ttgtttacta aatacctgtg aagaaatacc attaaaaaac tatttggttc     9780

tgaattctta ctagaaaaaa aa                                              9802


<210>  45
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Val Arg Asn 
    1340                 1345                 1350             


Asn Tyr  Asp Glu Glu Ile Ile  Ser Leu Lys Asn Gln  Phe Glu Thr 
    1355                 1360                 1365             


Glu Ile  Asn Ile Thr Lys Thr  Thr Ile His Gln Leu  Thr Met Gln 
    1370                 1375                 1380             


Lys Glu  Glu Asp Thr Ser Gly  Tyr Arg Ala Gln Ile  Asp Asn Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asn Arg Ser Leu  Ser Glu Glu Ile Lys  Arg Leu Lys 
    1400                 1405                 1410             


Asn Thr  Leu Thr Gln Thr Thr  Glu Asn Leu Arg Arg  Val Glu Glu 
    1415                 1420                 1425             


Asp Ile  Gln Gln Gln Lys Ala  Thr Gly Ser Glu Val  Ser Gln Arg 
    1430                 1435                 1440             


Lys Gln  Gln Leu Glu Val Glu  Leu Arg Gln Val Thr  Gln Met Arg 
    1445                 1450                 1455             


Thr Glu  Glu Ser Val Arg Tyr  Lys Gln Ser Leu Asp  Asp Ala Ala 
    1460                 1465                 1470             


Lys Thr  Ile Gln Asp Lys Asn  Lys Glu Ile Glu Arg  Leu Lys Gln 
    1475                 1480                 1485             


Leu Ile  Asp Lys Glu Thr Asn  Asp Arg Lys Cys Leu  Glu Asp Glu 
    1490                 1495                 1500             


Asn Ala  Arg Leu Gln Arg Val  Gln Tyr Asp Leu Gln  Lys Ala Asn 
    1505                 1510                 1515             


Ser Ser  Ala Thr Glu Thr Ile  Asn Lys Leu Lys Val  Gln Glu Gln 
    1520                 1525                 1530             


Glu Leu  Thr Arg Leu Arg Ile  Asp Tyr Glu Arg Val  Ser Gln Glu 
    1535                 1540                 1545             


Arg Thr  Val Lys Asp Gln Asp  Ile Thr Arg Phe Gln  Asn Ser Leu 
    1550                 1555                 1560             


Lys Glu  Leu Gln Leu Gln Lys  Gln Lys Val Glu Glu  Glu Leu Asn 
    1565                 1570                 1575             


Arg Leu  Lys Arg Thr Ala Ser  Glu Asp Ser Cys Lys  Arg Lys Lys 
    1580                 1585                 1590             


Leu Glu  Glu Glu Leu Glu Gly  Met Arg Arg Ser Leu  Lys Glu Gln 
    1595                 1600                 1605             


Ala Ile  Lys Ile Thr Asn Leu  Thr Gln Gln Leu Glu  Gln Ala Ser 
    1610                 1615                 1620             


Ile Val  Lys Lys Arg Ser Glu  Asp Asp Leu Arg Gln  Gln Arg Asp 
    1625                 1630                 1635             


Val Leu  Asp Gly His Leu Arg  Glu Lys Gln Arg Thr  Gln Glu Glu 
    1640                 1645                 1650             


Leu Arg  Arg Leu Ser Ser Glu  Val Glu Ala Leu Arg  Arg Gln Leu 
    1655                 1660                 1665             


Leu Gln  Glu Gln Glu Ser Val  Lys Gln Ala His Leu  Arg Asn Glu 
    1670                 1675                 1680             


His Phe  Gln Lys Ala Ile Glu  Asp Lys Ser Arg Ser  Leu Asn Glu 
    1685                 1690                 1695             


Ser Lys  Ile Glu Ile Glu Arg  Leu Gln Ser Leu Thr  Glu Asn Leu 
    1700                 1705                 1710             


Thr Lys  Glu His Leu Met Leu  Glu Glu Glu Leu Arg  Asn Leu Arg 
    1715                 1720                 1725             


Leu Glu  Tyr Asp Asp Leu Arg  Arg Gly Arg Ser Glu  Ala Asp Ser 
    1730                 1735                 1740             


Asp Lys  Asn Ala Thr Ile Leu  Glu Leu Arg Ser Gln  Leu Gln Ile 
    1745                 1750                 1755             


Ser Asn  Asn Arg Thr Leu Glu  Leu Gln Gly Leu Ile  Asn Asp Leu 
    1760                 1765                 1770             


Gln Arg  Glu Arg Glu Asn Leu  Arg Gln Glu Ile Glu  Lys Phe Gln 
    1775                 1780                 1785             


Lys Gln  Ala Leu Glu Ala Ser  Asn Arg Ile Gln Glu  Ser Lys Asn 
    1790                 1795                 1800             


Gln Cys  Thr Gln Val Val Gln  Glu Arg Glu Ser Leu  Leu Val Lys 
    1805                 1810                 1815             


Ile Lys  Val Leu Glu Gln Asp  Lys Ala Arg Leu Gln  Arg Leu Glu 
    1820                 1825                 1830             


Asp Glu  Leu Asn Arg Ala Lys  Ser Thr Leu Glu Ala  Glu Thr Arg 
    1835                 1840                 1845             


Val Lys  Gln Arg Leu Glu Cys  Glu Lys Gln Gln Ile  Gln Asn Asp 
    1850                 1855                 1860             


Leu Asn  Gln Trp Lys Thr Gln  Tyr Ser Arg Lys Glu  Glu Ala Ile 
    1865                 1870                 1875             


Arg Lys  Ile Glu Ser Glu Arg  Glu Lys Ser Glu Arg  Glu Lys Asn 
    1880                 1885                 1890             


Ser Leu  Arg Ser Glu Ile Glu  Arg Leu Gln Ala Glu  Ile Lys Arg 
    1895                 1900                 1905             


Ile Glu  Glu Arg Cys Arg Arg  Lys Leu Glu Asp Ser  Thr Arg Glu 
    1910                 1915                 1920             


Thr Gln  Ser Gln Leu Glu Thr  Glu Arg Ser Arg Tyr  Gln Arg Glu 
    1925                 1930                 1935             


Ile Asp  Lys Leu Arg Gln Arg  Pro Tyr Gly Ser His  Arg Glu Thr 
    1940                 1945                 1950             


Gln Thr  Glu Cys Glu Trp Thr  Val Asp Thr Ser Lys  Leu Val Phe 
    1955                 1960                 1965             


Asp Gly  Leu Arg Lys Lys Val  Thr Ala Met Gln Leu  Tyr Glu Cys 
    1970                 1975                 1980             


Gln Leu  Ile Asp Lys Thr Thr  Leu Asp Lys Leu Leu  Lys Gly Lys 
    1985                 1990                 1995             


Lys Ser  Val Glu Glu Val Ala  Ser Glu Ile Gln Pro  Phe Leu Arg 
    2000                 2005                 2010             


Gly Ala  Gly Ser Ile Ala Gly  Ala Ser Ala Ser Pro  Lys Glu Lys 
    2015                 2020                 2025             


Tyr Ser  Leu Val Glu Ala Lys  Arg Lys Lys Leu Ile  Ser Pro Glu 
    2030                 2035                 2040             


Ser Thr  Val Met Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Gly Ile 
    2045                 2050                 2055             


Ile Asp  Pro His Arg Asn Glu  Lys Leu Thr Val Asp  Ser Ala Ile 
    2060                 2065                 2070             


Ala Arg  Asp Leu Ile Asp Phe  Asp Asp Arg Gln Gln  Ile Tyr Ala 
    2075                 2080                 2085             


Ala Glu  Lys Ala Ile Thr Gly  Phe Asp Asp Pro Phe  Ser Gly Lys 
    2090                 2095                 2100             


Thr Val  Ser Val Ser Glu Ala  Ile Lys Lys Asn Leu  Ile Asp Arg 
    2105                 2110                 2115             


Glu Thr  Gly Met Arg Leu Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2120                 2125                 2130             


Val Val  Asp Pro Val Asn Ser  Val Phe Leu Pro Lys  Asp Val Ala 
    2135                 2140                 2145             


Leu Ala  Arg Gly Leu Ile Asp  Arg Asp Leu Tyr Arg  Ser Leu Asn 
    2150                 2155                 2160             


Asp Pro  Arg Asp Ser Gln Lys  Asn Phe Val Asp Pro  Val Thr Lys 
    2165                 2170                 2175             


Lys Lys  Val Ser Tyr Val Gln  Leu Lys Glu Arg Cys  Arg Ile Glu 
    2180                 2185                 2190             


Pro His  Thr Gly Leu Leu Leu  Leu Ser Val Gln Lys  Arg Ser Met 
    2195                 2200                 2205             


Ser Phe  Gln Gly Ile Arg Gln  Pro Val Thr Val Thr  Glu Leu Val 
    2210                 2215                 2220             


Asp Ser  Gly Ile Leu Arg Pro  Ser Thr Val Asn Glu  Leu Glu Ser 
    2225                 2230                 2235             


Gly Gln  Ile Ser Tyr Asp Glu  Val Gly Glu Arg Ile  Lys Asp Phe 
    2240                 2245                 2250             


Leu Gln  Gly Ser Ser Cys Ile  Ala Gly Ile Tyr Asn  Glu Thr Thr 
    2255                 2260                 2265             


Lys Gln  Lys Leu Gly Ile Tyr  Glu Ala Met Lys Ile  Gly Leu Val 
    2270                 2275                 2280             


Arg Pro  Gly Thr Ala Leu Glu  Leu Leu Glu Ala Gln  Ala Ala Thr 
    2285                 2290                 2295             


Gly Phe  Ile Val Asp Pro Val  Ser Asn Leu Arg Leu  Pro Val Glu 
    2300                 2305                 2310             


Glu Ala  Tyr Lys Arg Gly Leu  Val Gly Ile Glu Phe  Lys Glu Lys 
    2315                 2320                 2325             


Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly Tyr Asn  Asp Pro Glu 
    2330                 2335                 2340             


Thr Gly  Asn Ile Ile Ser Leu  Phe Gln Ala Met Asn  Lys Glu Leu 
    2345                 2350                 2355             


Ile Glu  Lys Gly His Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala 
    2360                 2365                 2370             


Thr Gly  Gly Ile Ile Asp Pro  Lys Glu Ser His Arg  Leu Pro Val 
    2375                 2380                 2385             


Asp Ile  Ala Tyr Lys Arg Gly  Tyr Phe Asn Glu Glu  Leu Ser Glu 
    2390                 2395                 2400             


Ile Leu  Ser Asp Pro Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro 
    2405                 2410                 2415             


Asn Thr  Glu Glu Asn Leu Thr  Tyr Leu Gln Leu Lys  Glu Arg Cys 
    2420                 2425                 2430             


Ile Lys  Asp Glu Glu Thr Gly  Leu Cys Leu Leu Pro  Leu Lys Glu 
    2435                 2440                 2445             


Lys Lys  Lys Gln Val Gln Thr  Ser Gln Lys Asn Thr  Leu Arg Lys 
    2450                 2455                 2460             


Arg Arg  Val Val Ile Val Asp  Pro Glu Thr Asn Lys  Glu Met Ser 
    2465                 2470                 2475             


Val Gln  Glu Ala Tyr Lys Lys  Gly Leu Ile Asp Tyr  Glu Thr Phe 
    2480                 2485                 2490             


Lys Glu  Leu Cys Glu Gln Glu  Cys Glu Trp Glu Glu  Ile Thr Ile 
    2495                 2500                 2505             


Thr Gly  Ser Asp Gly Ser Thr  Arg Val Val Leu Val  Asp Arg Lys 
    2510                 2515                 2520             


Thr Gly  Ser Gln Tyr Asp Ile  Gln Asp Ala Ile Asp  Lys Gly Leu 
    2525                 2530                 2535             


Val Asp  Arg Lys Phe Phe Asp  Gln Tyr Arg Ser Gly  Ser Leu Ser 
    2540                 2545                 2550             


Leu Thr  Gln Phe Ala Asp Met  Ile Ser Leu Lys Asn  Gly Val Gly 
    2555                 2560                 2565             


Thr Ser  Ser Ser Met Gly Ser  Gly Val Ser Asp Asp  Val Phe Ser 
    2570                 2575                 2580             


Ser Ser  Arg His Glu Ser Val  Ser Lys Ile Ser Thr  Ile Ser Ser 
    2585                 2590                 2595             


Val Arg  Asn Leu Thr Ile Arg  Ser Ser Ser Phe Ser  Asp Thr Leu 
    2600                 2605                 2610             


Glu Glu  Ser Ser Pro Ile Ala  Ala Ile Phe Asp Thr  Glu Asn Leu 
    2615                 2620                 2625             


Glu Lys  Ile Ser Ile Thr Glu  Gly Ile Glu Arg Gly  Ile Val Asp 
    2630                 2635                 2640             


Ser Ile  Thr Gly Gln Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly 
    2645                 2650                 2655             


Gly Ile  Ile His Pro Thr Thr  Gly Gln Lys Leu Ser  Leu Gln Asp 
    2660                 2665                 2670             


Ala Val  Ser Gln Gly Val Ile  Asp Gln Asp Met Ala  Thr Arg Leu 
    2675                 2680                 2685             


Lys Pro  Ala Gln Lys Ala Phe  Ile Gly Phe Glu Gly  Val Lys Gly 
    2690                 2695                 2700             


Lys Lys  Lys Met Ser Ala Ala  Glu Ala Val Lys Glu  Lys Trp Leu 
    2705                 2710                 2715             


Pro Tyr  Glu Ala Gly Gln Arg  Phe Leu Glu Phe Gln  Tyr Leu Thr 
    2720                 2725                 2730             


Gly Gly  Leu Val Asp Pro Glu  Val His Gly Arg Ile  Ser Thr Glu 
    2735                 2740                 2745             


Glu Ala  Ile Arg Lys Gly Phe  Ile Asp Gly Arg Ala  Ala Gln Arg 
    2750                 2755                 2760             


Leu Gln  Asp Thr Ser Ser Tyr  Ala Lys Ile Leu Thr  Cys Pro Lys 
    2765                 2770                 2775             


Thr Lys  Leu Lys Ile Ser Tyr  Lys Asp Ala Ile Asn  Arg Ser Met 
    2780                 2785                 2790             


Val Glu  Asp Ile Thr Gly Leu  Arg Leu Leu Glu Ala  Ala Ser Val 
    2795                 2800                 2805             


Ser Ser  Lys Gly Leu Pro Ser  Pro Tyr Asn Met Ser  Ser Ala Pro 
    2810                 2815                 2820             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2825                 2830                 2835             


Ser Gly  Ser Arg Ser Gly Ser  Arg Arg Gly Ser Phe  Asp Ala Thr 
    2840                 2845                 2850             


Gly Asn  Ser Ser Tyr Ser Tyr  Ser Tyr Ser Phe Ser  Ser Ser Ser 
    2855                 2860                 2865             


Ile Gly  His 
    2870     


<210>  46
<211>  8473
<212>  DNA
<213>  Homo sapiens

<400>  46
aagaaaccgg ccaggtgtgg cctaggcgcc cagtgccagc ggggaggaga ctcgctccgc       60

cgccgaccaa caccaacacc cagctccgac gcagctcctc tgcgcccttg ccgccctccg      120

agccacagct ttcctcccgc tcctgccccc ggcccgtcgc cgtctccgcg ctcgcagcgg      180

cctcgggagg gcccaggtag cgagcagcga cctcgcgagc cttccgcact cccgcccggt      240

tccccggccg tccgcctatc cttggccccc tccgctttct ccgcgccggc ccgcctcgct      300

tatgcctcgg cgctgagccg ctctcccgat tgcccgccga catgagctgc aacggaggct      360

cccacccgcg gatcaacact ctgggccgca tgatccgcgc cgagtctggc ccggacctgc      420

gctacgaggt gaccagcggc ggcgggggca ccagcaggat gtactattct cggcgcggcg      480

tgatcaccga ccagaactcg gacggctact gtcaaaccgg cacgatgtcc aggcaccaga      540

accagaacac catccaggag ctgctgcaga actgctccga ctgcttgatg cgagcagagc      600

tcatcgtgca gcctgaattg aagtatggag atggaataca actgactcgg agtcgagaat      660

tggatgagtg ttttgcccag gccaatgacc aaatggaaat cctcgacagc ttgatcagag      720

agatgcggca gatgggccag ccctgtgatg cttaccagaa aaggcttctt cagctccaag      780

agcaaatgcg agccctttat aaagccatca gtgtccctcg agtccgcagg gccagctcca      840

agggtggtgg aggctacact tgtcagagtg gctctggctg ggatgagttc accaaacatg      900

tcaccagtga atgtttgggg tggatgaggc agcaaagggc ggagatggac atggtggcct      960

ggggtgtgga cctggcctca gtggagcagc acattaacag ccaccggggc atccacaact     1020

ccatcggcga ctatcgctgg cagctggaca aaatcaaagc cgacctgcgc gagaaatctg     1080

cgatctacca gttggaggag gagtatgaaa acctgctgaa agcgtccttt gagaggatgg     1140

atcacctgcg acagctgcag aacatcattc aggccacgtc cagggagatc atgtggatca     1200

atgactgcga ggaggaggag ctgctgtacg actggagcga caagaacacc aacatcgctc     1260

agaaacagga ggccttctcc atacgcatga gtcaactgga agttaaagaa aaagagctca     1320

ataagctgaa acaagaaagt gaccaacttg tcctcaatca gcatccagct tcagacaaaa     1380

ttgaggccta tatggacact ctgcagacgc agtggagttg gattcttcag atcaccaagt     1440

gcattgatgt tcatctgaaa gaaaatgctg cctactttca gttttttgaa gaggcgcagt     1500

ctactgaagc atacctgaag gggctccagg actccatcag gaagaagtac ccctgcgaca     1560

agaacatgcc cctgcagcac ctgctggaac agatcaagga gctggagaaa gaacgagaga     1620

aaatccttga atacaagcgt caggtgcaga acttggtaaa caagtctaag aagattgtac     1680

agctgaagcc tcgtaaccca gactacagaa gcaataaacc cattattctc agagctctct     1740

gtgactacaa acaagatcag aaaatcgtgc ataaggggga tgagtgtatc ctgaaggaca     1800

acaacgagcg cagcaagtgg tacgtgacgg gcccgggagg cgttgacatg cttgttccct     1860

ctgtggggct gatcatccct cctccgaacc cactggccgt ggacctctct tgcaagattg     1920

agcagtacta cgaagccatc ttggctctgt ggaaccagct ctacatcaac atgaagagcc     1980

tggtgtcctg gcactactgc atgattgaca tagagaagat cagggccatg acaatcgcca     2040

agctgaaaac aatgcggcag gaagattaca tgaagacgat agccgacctt gagttacatt     2100

accaagagtt catcagaaat agccaaggct cagagatgtt tggagatgat gacaagcgga     2160

aaatacagtc tcagttcacc gatgcccaga agcattacca gaccctggtc attcagctcc     2220

ctggctatcc ccagcaccag acagtgacca caactgaaat cactcatcat ggaacctgcc     2280

aagatgtcaa ccataataaa gtaattgaaa ccaacagaga aaatgacaag caagaaacat     2340

ggatgctgat ggagctgcag aagattcgca ggcagataga gcactgcgag ggcaggatga     2400

ctctcaaaaa cctccctcta gcagaccagg gatcttctca ccacatcaca gtgaaaatta     2460

acgagcttaa gagtgtgcag aatgattcac aagcaattgc tgaggttctc aaccagctta     2520

aagatatgct tgccaacttc agaggttctg aaaagtactg ctatttacag aatgaagtat     2580

ttggactatt tcagaaactg gaaaatatca atggtgttac agatggctac ttaaatagct     2640

tatgcacagt aagggcactg ctccaggcta ttctccaaac agaagacatg ttaaaggttt     2700

atgaagccag gctcactgag gaggaaactg tctgcctgga cctggataaa gtggaagctt     2760

accgctgtgg actgaagaaa ataaaaaatg acttgaactt gaagaagtcg ttgttggcca     2820

ctatgaagac agaactacag aaagcccagc agatccactc tcagacttca cagcagtatc     2880

cactttatga tctggacttg ggcaagttcg gtgaaaaagt cacacagctg acagaccgct     2940

ggcaaaggat agataaacag atcgacttta ggttatggga cctggagaaa caaatcaagc     3000

aattgaggaa ttatcgtgat aactatcagg ctttctgcaa gtggctctat gatgctaaac     3060

gccgccagga ttccttagaa tccatgaaat ttggagattc caacacagtc atgcggtttt     3120

tgaatgagca gaagaacttg cacagtgaaa tatctggcaa acgagacaaa tcagaggaag     3180

tacaaaaaat tgctgaactt tgcgccaatt caattaagga ttatgagctc cagctggcct     3240

catacacctc aggactggaa actctgctga acatacctat caagaggacc atgattcagt     3300

ccccttctgg ggtgattctg caagaggctg cagatgttca tgctcggtac attgaactac     3360

ttacaagatc tggagactat tacaggttct taagtgagat gctgaagagt ttggaagatc     3420

tgaagctgaa aaataccaag atcgaagttt tggaagagga gctcagactg gcccgagatg     3480

ccaactcgga aaactgtaat aagaacaaat tcctggatca gaacctgcag aaataccagg     3540

cagagtgttc ccagttcaaa gcgaagcttg cgagcctgga ggagctgaag agacaggctg     3600

agctggatgg gaagtcggct aagcaaaatc tagacaagtg ctacggccaa ataaaagaac     3660

tcaatgagaa gatcacccga ctgacttatg agattgaaga tgaaaagaga agaagaaaat     3720

ctgtggaaga cagatttgac caacagaaga atgactatga ccaactgcag aaagcaaggc     3780

aatgtgaaaa ggagaacctt ggttggcaga aattagagtc tgagaaagcc atcaaggaga     3840

aggagtacga gattgaaagg ttgagggttc tactgcagga agaaggcacc cggaagagag     3900

aatatgaaaa tgagctggca aaggtaagaa accactataa tgaggagatg agtaatttaa     3960

ggaacaagta tgaaacagag attaacatta cgaagaccac catcaaggag atatccatgc     4020

aaaaagagga tgattccaaa aatcttagaa accagcttga tagactttca agggaaaatc     4080

gagatctgaa ggatgaaatt gtcaggctca atgacagcat cttgcaggcc actgagcagc     4140

gaaggcgagc tgaagaaaac gcccttcagc aaaaggcctg tggctctgag ataatgcaga     4200

agaagcagca tctggagata gaactgaagc aggtcatgca gcagcgctct gaggacaatg     4260

cccggcacaa gcagtccctg gaggaggctg ccaagaccat tcaggacaaa aataaggaga     4320

tcgagagact caaagctgag tttcaggagg aggccaagcg ccgctgggaa tatgaaaatg     4380

aactgagtaa ggcatctaat aggattcagg aatcaaagaa tcagtgtact caggtggtac     4440

aggaaagaga gagccttctg gtgaaaatca aagtcctgga gcaagacaag gcaaggctgc     4500

agaggctgga ggatgagctg aatcgtgcaa aatcaactct agaggcagaa accagggtga     4560

aacagcgcct ggagtgtgag aaacagcaaa ttcagaatga cctgaatcag tggaagactc     4620

aatattcccg caaggaggag gctattagga agatagaatc ggaaagagaa aagagtgaga     4680

gagagaagaa cagtcttagg agtgagatcg aaagactcca agcagagatc aagagaattg     4740

aagagaggtg caggcgtaag ctggaggatt ctaccaggga gacacagtca cagttagaaa     4800

cagaacgctc ccgatatcag agggagattg ataaactcag acagcgccca tatgggtccc     4860

atcgagagac ccagactgag tgtgagtgga ccgttgacac ctccaagctg gtgtttgatg     4920

ggctgaggaa gaaggtgaca gcaatgcagc tctatgagtg tcagctgatc gacaaaacaa     4980

ccttggacaa actattgaag gggaagaagt cagtggaaga agttgcttct gaaatccagc     5040

cattccttcg gggtgcagga tctatcgctg gagcatctgc ttctcctaag gaaaaatact     5100

ctttggtaga ggccaagaga aagaaattaa tcagcccaga atccacagtc atgcttctgg     5160

aggcccaggc agctacaggt ggtataattg atccccatcg gaatgagaag ctgactgtcg     5220

acagtgccat agctcgggac ctcattgact tcgatgaccg tcagcagata tatgcagcag     5280

aaaaagctat cactggtttt gatgatccat tttcaggcaa gacagtatct gtttcagaag     5340

ccatcaagaa aaatttgatt gatagagaaa ccggaatgcg cctgctggaa gcccagattg     5400

cttcaggggg tgtagtagac cctgtgaaca gtgtcttttt gccaaaagat gtcgccttgg     5460

cccgggggct gattgataga gatttgtatc gatccctgaa tgatccccga gatagtcaga     5520

aaaactttgt ggatccagtc accaaaaaga aggtcagtta cgtgcagctg aaggaacggt     5580

gcagaatcga accacatact ggtctgctct tgctttcagt acagaagaga agcatgtcct     5640

tccaaggaat cagacaacct gtgaccgtca ctgagctagt agattctggt atattgagac     5700

cgtccactgt caatgaactg gaatctggtc agatttctta tgacgaggtt ggtgagagaa     5760

ttaaggactt cctccagggt tcaagctgca tagcaggcat atacaatgag accacaaaac     5820

agaagcttgg catttatgag gccatgaaaa ttggcttagt ccgacctggt actgctctgg     5880

agttgctgga agcccaagca gctactggct ttatagtgga tcctgttagc aacttgaggt     5940

taccagtgga ggaagcctac aagagaggtc tggtgggcat tgagttcaaa gagaagctcc     6000

tgtctgcaga acgagctgtc actgggtata atgatcctga aacaggaaac atcatctctt     6060

tgttccaagc catgaataag gaactcatcg aaaagggcca cggtattcgc ttattagaag     6120

cacagatcgc aaccgggggg atcattgacc caaaggagag ccatcgttta ccagttgaca     6180

tagcatataa gaggggctat ttcaatgagg aactcagtga gattctctca gatccaagtg     6240

atgataccaa aggatttttt gaccccaaca ctgaagaaaa tcttacctat ctgcaactaa     6300

aagaaagatg cattaaggat gaggaaacag ggctctgtct tctgcctctg aaagaaaaga     6360

agaaacaggt gcagacatca caaaagaata ccctcaggaa gcgtagagtg gtcatagttg     6420

acccagaaac caataaagaa atgtctgttc aggaggccta caagaagggc ctaattgatt     6480

atgaaacctt caaagaactg tgtgagcagg aatgtgaatg ggaagaaata accatcacgg     6540

gatcagatgg ctccaccagg gtggtcctgg tagatagaaa gacaggcagt cagtatgata     6600

ttcaagatgc tattgacaag ggccttgttg acaggaagtt ctttgatcag taccgatccg     6660

gcagcctcag cctcactcaa tttgctgaca tgatctcctt gaaaaatggt gtcggcacca     6720

gcagcagcat gggcagtggt gtcagcgatg atgtttttag cagctcccga catgaatcag     6780

taagtaagat ttccaccata tccagcgtca ggaatttaac cataaggagc agctcttttt     6840

cagacaccct ggaagaatcg agccccattg cagccatctt tgacacagaa aacctggaga     6900

aaatctccat tacagaaggt atagagcggg gcatcgttga cagcatcacg ggtcagaggc     6960

ttctggaggc tcaggcctgc acaggtggca tcatccaccc aaccacgggc cagaagctgt     7020

cacttcagga cgcagtctcc cagggtgtga ttgaccaaga catggccacc aggctgaagc     7080

ctgctcagaa agccttcata ggcttcgagg gtgtgaaggg aaagaagaag atgtcagcag     7140

cagaggcagt gaaagaaaaa tggctcccgt atgaggctgg ccagcgcttc ctggagttcc     7200

agtacctcac gggaggtctt gttgacccgg aagtgcatgg gaggataagc accgaagaag     7260

ccatccggaa ggggttcata gatggccgcg ccgcacagag gctgcaagac accagcagct     7320

atgccaaaat cctgacctgc cccaaaacca aattaaaaat atcctataag gatgccataa     7380

atcgctccat ggtagaagat atcactgggc tgcgccttct ggaagccgcc tccgtgtcgt     7440

ccaagggctt acccagccct tacaacatgt cttcggctcc ggggtcccgc tccggctccc     7500

gctcgggatc tcgctccgga tctcgctccg ggtcccgcag tgggtcccgg agaggaagct     7560

ttgacgccac agggaattct tcctactctt attcctactc atttagcagt agttctattg     7620

ggcactagta gtcagttggg agtggttgct ataccttgac ttcatttata tgaatttcca     7680

ctttattaaa taatagaaaa gaaaatcccg gtgcttgcag tagagtgata ggacattcta     7740

tgcttacaga aaatatagcc atgattgaaa tcaaatagta aaggctgttc tggcttttta     7800

tcttcttagc tcatcttaaa taagcagtac acttggatgc agtgcgtctg aagtgctaat     7860

cagttgtaac aatagcacaa atcgaactta ggatttgttt cttctcttct gtgtttcgat     7920

ttttgatcaa ttctttaatt ttggaagcct ataatacagt tttctattct tggagataaa     7980

aattaaatgg atcactgata ttttagtcat tctgcttctc atctaaatat ttccatattc     8040

tgtattagga gaaaattacc ctcccagcac cagcccccct ctcaaacccc caacccaaaa     8100

ccaagcattt tggaatgagt ctcctttagt ttcagagtgt ggattgtata acccatatac     8160

tcttcgatgt acttgtttgg tttggtatta atttgactgt gcatgacagc ggcaatcttt     8220

tctttggtca aagttttctg tttattttgc ttgtcatatt cgatgtactt taaggtgtct     8280

ttatgaagtt tgctattctg gcaataaact tttagacttt tgaagtgttt gtgttttaat     8340

ttaatatgtt tataagcatg tataaacatt tagcatattt ttatcatagg tctaaaaata     8400

tttgtttact aaatacctgt gaagaaatac cattaaaaaa ctatttggtt ctgaattctt     8460

actagaaaaa aaa                                                        8473


<210>  47
<211>  2428
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Ala Ser Asn 
    1340                 1345                 1350             


Arg Ile  Gln Glu Ser Lys Asn  Gln Cys Thr Gln Val  Val Gln Glu 
    1355                 1360                 1365             


Arg Glu  Ser Leu Leu Val Lys  Ile Lys Val Leu Glu  Gln Asp Lys 
    1370                 1375                 1380             


Ala Arg  Leu Gln Arg Leu Glu  Asp Glu Leu Asn Arg  Ala Lys Ser 
    1385                 1390                 1395             


Thr Leu  Glu Ala Glu Thr Arg  Val Lys Gln Arg Leu  Glu Cys Glu 
    1400                 1405                 1410             


Lys Gln  Gln Ile Gln Asn Asp  Leu Asn Gln Trp Lys  Thr Gln Tyr 
    1415                 1420                 1425             


Ser Arg  Lys Glu Glu Ala Ile  Arg Lys Ile Glu Ser  Glu Arg Glu 
    1430                 1435                 1440             


Lys Ser  Glu Arg Glu Lys Asn  Ser Leu Arg Ser Glu  Ile Glu Arg 
    1445                 1450                 1455             


Leu Gln  Ala Glu Ile Lys Arg  Ile Glu Glu Arg Cys  Arg Arg Lys 
    1460                 1465                 1470             


Leu Glu  Asp Ser Thr Arg Glu  Thr Gln Ser Gln Leu  Glu Thr Glu 
    1475                 1480                 1485             


Arg Ser  Arg Tyr Gln Arg Glu  Ile Asp Lys Leu Arg  Gln Arg Pro 
    1490                 1495                 1500             


Tyr Gly  Ser His Arg Glu Thr  Gln Thr Glu Cys Glu  Trp Thr Val 
    1505                 1510                 1515             


Asp Thr  Ser Lys Leu Val Phe  Asp Gly Leu Arg Lys  Lys Val Thr 
    1520                 1525                 1530             


Ala Met  Gln Leu Tyr Glu Cys  Gln Leu Ile Asp Lys  Thr Thr Leu 
    1535                 1540                 1545             


Asp Lys  Leu Leu Lys Gly Lys  Lys Ser Val Glu Glu  Val Ala Ser 
    1550                 1555                 1560             


Glu Ile  Gln Pro Phe Leu Arg  Gly Ala Gly Ser Ile  Ala Gly Ala 
    1565                 1570                 1575             


Ser Ala  Ser Pro Lys Glu Lys  Tyr Ser Leu Val Glu  Ala Lys Arg 
    1580                 1585                 1590             


Lys Lys  Leu Ile Ser Pro Glu  Ser Thr Val Met Leu  Leu Glu Ala 
    1595                 1600                 1605             


Gln Ala  Ala Thr Gly Gly Ile  Ile Asp Pro His Arg  Asn Glu Lys 
    1610                 1615                 1620             


Leu Thr  Val Asp Ser Ala Ile  Ala Arg Asp Leu Ile  Asp Phe Asp 
    1625                 1630                 1635             


Asp Arg  Gln Gln Ile Tyr Ala  Ala Glu Lys Ala Ile  Thr Gly Phe 
    1640                 1645                 1650             


Asp Asp  Pro Phe Ser Gly Lys  Thr Val Ser Val Ser  Glu Ala Ile 
    1655                 1660                 1665             


Lys Lys  Asn Leu Ile Asp Arg  Glu Thr Gly Met Arg  Leu Leu Glu 
    1670                 1675                 1680             


Ala Gln  Ile Ala Ser Gly Gly  Val Val Asp Pro Val  Asn Ser Val 
    1685                 1690                 1695             


Phe Leu  Pro Lys Asp Val Ala  Leu Ala Arg Gly Leu  Ile Asp Arg 
    1700                 1705                 1710             


Asp Leu  Tyr Arg Ser Leu Asn  Asp Pro Arg Asp Ser  Gln Lys Asn 
    1715                 1720                 1725             


Phe Val  Asp Pro Val Thr Lys  Lys Lys Val Ser Tyr  Val Gln Leu 
    1730                 1735                 1740             


Lys Glu  Arg Cys Arg Ile Glu  Pro His Thr Gly Leu  Leu Leu Leu 
    1745                 1750                 1755             


Ser Val  Gln Lys Arg Ser Met  Ser Phe Gln Gly Ile  Arg Gln Pro 
    1760                 1765                 1770             


Val Thr  Val Thr Glu Leu Val  Asp Ser Gly Ile Leu  Arg Pro Ser 
    1775                 1780                 1785             


Thr Val  Asn Glu Leu Glu Ser  Gly Gln Ile Ser Tyr  Asp Glu Val 
    1790                 1795                 1800             


Gly Glu  Arg Ile Lys Asp Phe  Leu Gln Gly Ser Ser  Cys Ile Ala 
    1805                 1810                 1815             


Gly Ile  Tyr Asn Glu Thr Thr  Lys Gln Lys Leu Gly  Ile Tyr Glu 
    1820                 1825                 1830             


Ala Met  Lys Ile Gly Leu Val  Arg Pro Gly Thr Ala  Leu Glu Leu 
    1835                 1840                 1845             


Leu Glu  Ala Gln Ala Ala Thr  Gly Phe Ile Val Asp  Pro Val Ser 
    1850                 1855                 1860             


Asn Leu  Arg Leu Pro Val Glu  Glu Ala Tyr Lys Arg  Gly Leu Val 
    1865                 1870                 1875             


Gly Ile  Glu Phe Lys Glu Lys  Leu Leu Ser Ala Glu  Arg Ala Val 
    1880                 1885                 1890             


Thr Gly  Tyr Asn Asp Pro Glu  Thr Gly Asn Ile Ile  Ser Leu Phe 
    1895                 1900                 1905             


Gln Ala  Met Asn Lys Glu Leu  Ile Glu Lys Gly His  Gly Ile Arg 
    1910                 1915                 1920             


Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly Ile Ile  Asp Pro Lys 
    1925                 1930                 1935             


Glu Ser  His Arg Leu Pro Val  Asp Ile Ala Tyr Lys  Arg Gly Tyr 
    1940                 1945                 1950             


Phe Asn  Glu Glu Leu Ser Glu  Ile Leu Ser Asp Pro  Ser Asp Asp 
    1955                 1960                 1965             


Thr Lys  Gly Phe Phe Asp Pro  Asn Thr Glu Glu Asn  Leu Thr Tyr 
    1970                 1975                 1980             


Leu Gln  Leu Lys Glu Arg Cys  Ile Lys Asp Glu Glu  Thr Gly Leu 
    1985                 1990                 1995             


Cys Leu  Leu Pro Leu Lys Glu  Lys Lys Lys Gln Val  Gln Thr Ser 
    2000                 2005                 2010             


Gln Lys  Asn Thr Leu Arg Lys  Arg Arg Val Val Ile  Val Asp Pro 
    2015                 2020                 2025             


Glu Thr  Asn Lys Glu Met Ser  Val Gln Glu Ala Tyr  Lys Lys Gly 
    2030                 2035                 2040             


Leu Ile  Asp Tyr Glu Thr Phe  Lys Glu Leu Cys Glu  Gln Glu Cys 
    2045                 2050                 2055             


Glu Trp  Glu Glu Ile Thr Ile  Thr Gly Ser Asp Gly  Ser Thr Arg 
    2060                 2065                 2070             


Val Val  Leu Val Asp Arg Lys  Thr Gly Ser Gln Tyr  Asp Ile Gln 
    2075                 2080                 2085             


Asp Ala  Ile Asp Lys Gly Leu  Val Asp Arg Lys Phe  Phe Asp Gln 
    2090                 2095                 2100             


Tyr Arg  Ser Gly Ser Leu Ser  Leu Thr Gln Phe Ala  Asp Met Ile 
    2105                 2110                 2115             


Ser Leu  Lys Asn Gly Val Gly  Thr Ser Ser Ser Met  Gly Ser Gly 
    2120                 2125                 2130             


Val Ser  Asp Asp Val Phe Ser  Ser Ser Arg His Glu  Ser Val Ser 
    2135                 2140                 2145             


Lys Ile  Ser Thr Ile Ser Ser  Val Arg Asn Leu Thr  Ile Arg Ser 
    2150                 2155                 2160             


Ser Ser  Phe Ser Asp Thr Leu  Glu Glu Ser Ser Pro  Ile Ala Ala 
    2165                 2170                 2175             


Ile Phe  Asp Thr Glu Asn Leu  Glu Lys Ile Ser Ile  Thr Glu Gly 
    2180                 2185                 2190             


Ile Glu  Arg Gly Ile Val Asp  Ser Ile Thr Gly Gln  Arg Leu Leu 
    2195                 2200                 2205             


Glu Ala  Gln Ala Cys Thr Gly  Gly Ile Ile His Pro  Thr Thr Gly 
    2210                 2215                 2220             


Gln Lys  Leu Ser Leu Gln Asp  Ala Val Ser Gln Gly  Val Ile Asp 
    2225                 2230                 2235             


Gln Asp  Met Ala Thr Arg Leu  Lys Pro Ala Gln Lys  Ala Phe Ile 
    2240                 2245                 2250             


Gly Phe  Glu Gly Val Lys Gly  Lys Lys Lys Met Ser  Ala Ala Glu 
    2255                 2260                 2265             


Ala Val  Lys Glu Lys Trp Leu  Pro Tyr Glu Ala Gly  Gln Arg Phe 
    2270                 2275                 2280             


Leu Glu  Phe Gln Tyr Leu Thr  Gly Gly Leu Val Asp  Pro Glu Val 
    2285                 2290                 2295             


His Gly  Arg Ile Ser Thr Glu  Glu Ala Ile Arg Lys  Gly Phe Ile 
    2300                 2305                 2310             


Asp Gly  Arg Ala Ala Gln Arg  Leu Gln Asp Thr Ser  Ser Tyr Ala 
    2315                 2320                 2325             


Lys Ile  Leu Thr Cys Pro Lys  Thr Lys Leu Lys Ile  Ser Tyr Lys 
    2330                 2335                 2340             


Asp Ala  Ile Asn Arg Ser Met  Val Glu Asp Ile Thr  Gly Leu Arg 
    2345                 2350                 2355             


Leu Leu  Glu Ala Ala Ser Val  Ser Ser Lys Gly Leu  Pro Ser Pro 
    2360                 2365                 2370             


Tyr Asn  Met Ser Ser Ala Pro  Gly Ser Arg Ser Gly  Ser Arg Ser 
    2375                 2380                 2385             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2390                 2395                 2400             


Arg Gly  Ser Phe Asp Ala Thr  Gly Asn Ser Ser Tyr  Ser Tyr Ser 
    2405                 2410                 2415             


Tyr Ser  Phe Ser Ser Ser Ser  Ile Gly His 
    2420                 2425             


<210>  48
<211>  8768
<212>  DNA
<213>  Homo sapiens

<400>  48
gcggccgcac tagtaccccg gagcccatgg gcgcgccgag ccgggcgcgg gggcgctgaa       60

cggcggagcg ggagcggccg gaggagccat ggactgcagc ctcgtgcgga cgctcgtgca      120

cagatactgt gcaggagaag agaattgggt ggacagcagg accatctacg tgggacacag      180

ggagccacct ccgggcgcag aggcctacat cccacagaga tacccagaca acaggatcgt      240

ctcgtccaag tacacatttt ggaactttat acccaagaat ttatttgaac aattcagaag      300

agtagccaac ttttatttcc ttatcatatt tctggtgcag ttgattattg atacacccac      360

aagtccagtg acaagcggac ttccactctt ctttgtcatt actgtgacgg ctatcaaaca      420

gggttatgaa gactggcttc gacataaagc agacaatgcc atgaaccagt gtcctgttca      480

tttcattcag cacggcaagc tcgttcggaa acaaagtcga aagctgcgag ttggggacat      540

tgtcatggtt aaggaggacg agacctttcc ctgcgacttg atcttccttt ccagcaaccg      600

gggagatggg acgtgccacg tcaccaccgc cagcttggat ggagaatcca gccataaaac      660

gcattacgcg gtccaggaca ccaaaggctt ccacacagag gaggatatcg gcggacttca      720

cgccaccatc gagtgtgagc agccccagcc cgacctctac aagttcgtgg gtcgcatcaa      780

cgtttacagt gacctgaatg accccgtggt gaggccctta ggatcggaaa acctgctgct      840

tagaggagct acactgaaga acactgagaa aatctttggt gtggctattt acacgggaat      900

ggaaaccaag atggcattaa attatcaatc aaaatctcag aagcgatctg ccgtggaaaa      960

atcgatgaat gcgttcctca ttgtgtatct ctgcattctg atcagcaaag ccctgataaa     1020

cactgtgctg aaatacatgt ggcagagtga gccctttcgg gatgagccgt ggtataatca     1080

gaaaacggag tcggaaaggc agaggaatct gttcctcaag gcattcacgg acttcctggc     1140

cttcatggtc ctctttaact acatcatccc tgtgtccatg tacgtcacgg tcgagatgca     1200

gaagttcctc ggctcttact tcatcacctg ggacgaagac atgtttgacg aggagactgg     1260

cgaggggcct ctggtgaaca cgtcggacct caatgaagag ctgggacagg tggagtacat     1320

cttcacagac aagaccggca ccctcacgga aaacaacatg gagttcaagg agtgctgcat     1380

cgaaggccat gtctacgtgc cccacgtcat ctgcaacggg caggtcctcc cagagtcgtc     1440

aggaatcgac atgattgact cgtcccccag cgtcaacggg agggagcgcg aggagctgtt     1500

tttccgggcc ctctgtctct gccacaccgt ccaggtgaaa gacgatgaca gcgtagacgg     1560

ccccaggaaa tcgccggacg gggggaaatc ctgtgtgtac atctcatcct cgcccgacga     1620

ggtggcgctg gtcgaaggtg tccagagact tggctttacc tacctaaggc tgaaggacaa     1680

ttacatggag atattaaaca gggagaacca catcgaaagg tttgaattgc tggaaatttt     1740

gagttttgac tcagtcagaa ggagaatgag tgtaattgta aaatctgcta caggagaaat     1800

ttatctgttt tgcaaaggag cagattcttc gatattcccc cgagtgatag aaggcaaagt     1860

tgaccagatc cgagccagag tggagcgtaa cgcagtggag gggctccgaa ctttgtgtgt     1920

tgcttataaa aggctgatcc aagaagaata tgaaggcatt tgtaagctgc tgcaggctgc     1980

caaagtggcc cttcaagatc gagagaaaaa gttagcagaa gcctatgagc aaatagagaa     2040

agatcttact ctgcttggtg ctacagctgt tgaggaccgg ctgcaggaga aagctgcaga     2100

caccatcgag gccctgcaga aggccgggat caaagtctgg gttctcacgg gagacaagat     2160

ggagacggcc gcggccacgt gctacgcctg caagctcttc cgcaggaaca cgcagctgct     2220

ggagctgacc accaagagga tcgaggagca gagcctgcac gacgtcctgt tcgagctgag     2280

caagacggtc ctgcgccaca gcgggagcct gaccagagac aacctgtccg gactttcagc     2340

agatatgcag gactacggtt taattatcga cggagctgca ctgtctctga taatgaagcc     2400

tcgagaagac gggagttccg gcaactacag ggagctcttc ctggaaatct gccggagctg     2460

cagcgcggtg ctctgctgcc gcatggcgcc cttgcagaag gctcagattg ttaaattaat     2520

caaattttca aaagagcacc caatcacgtt agcaattggc gatggtgcaa atgatgtcag     2580

catgattctg gaagcgcacg tgggcatagg tgtcatcggc aaggaaggcc gccaggctgc     2640

caggaacagc gactatgcaa tcccaaagtt taagcatttg aagaagatgc tgcttgttca     2700

cgggcatttt tattacatta ggatctctga gctcgtgcag tacttcttct ataagaacgt     2760

ctgcttcatc ttccctcagt ttttatacca gttcttctgt gggttttcac aacagacttt     2820

gtacgacacc gcgtatctga ccctctacaa catcagcttc acctccctcc ccatcctcct     2880

gtacagcctc atggagcagc atgttggcat tgacgtgctc aagagagacc cgaccctgta     2940

cagggacgtc gccaagaatg ccctgctgcg ctggcgcgtg ttcatctact ggacgctcct     3000

gggactgttt gacgcactgg tgttcttctt tggtgcttat ttcgtgtttg aaaatacaac     3060

tgtgacaagc aacgggcaga tatttggaaa ctggacgttt ggaacgctgg tattcaccgt     3120

gatggtgttc acagttacac taaagcttgc attggacaca cactactgga cttggatcaa     3180

ccattttgtc atctgggggt cgctgctgtt ctacgttgtc ttttcgcttc tctggggagg     3240

agtgatctgg ccgttcctca actaccagag gatgtactac gtgttcatcc agatgctgtc     3300

cagcgggccc gcctggctgg ccatcgtgct gctggtgacc atcagcctcc ttcccgacgt     3360

cctcaagaaa gtcctgtgcc ggcagctgtg gccaacagca acagagagag tccagaatgg     3420

gtgcgcacag cctcgggacc gcgactcaga attcacccct cttgcctctc tgcagagccc     3480

aggctaccag agcacctgtc cctcggccgc ctggtacagc tcccactctc agcaggtgac     3540

actcgcggcc tggaaggaga aggtgtccac ggagccccca cccatcctcg gcggttccca     3600

tcaccactgc agttccatcc caagtcacag ctgccctagg tcccgtgtgg gaatgctcgt     3660

gtgatggatg gtcctaagcc tgtggagact gtgcacgtgc ctcttcctgg cccccagcag     3720

gcaaggaggg gggtcacagg ccttgccctc gagcatggca ccctggccgc ctggacccag     3780

cactgtggtt gttgagccac accagtggcc tctgggcatt cggctcaacg caggagggac     3840

attctgctgg cccaccctgc gcgctgtcat gcagaggcca ttcccccagg cctgtgtctt     3900

cacccacctg ccatcattgg cctttgctgt cactgggaga gaagagccgt ccagggaccc     3960

atggtggccc acatgtggat gccacatgct gctgtttcct gcttgcccgg ccaccaccca     4020

tgccctccat agggtgaggt ggagccatgg tggtgcgtcc tttactcaac aaccctccaa     4080

tccggatgct gtgggaaggg ccgggtcact cggataccat catccctgcg gatgcaccgc     4140

cgtaccctgc tcatctggga gtggtttccc tgcggttacg tccaagcccg cctgccctgt     4200

gtgttggggc tggctgagtt tcggtctccc catcaccggc cgcctcgtgg agaaggcagt     4260

gccacgtggg aggacaaggc cacgccggca gcttccagcc ctgccgcaga agtgccagga     4320

tgtccatcag ccactcgcca gggcacggag ccgtcagtcc actgttacgg gagaatgttg     4380

atttcgcggg tgcgagggcc gggagacaga tacttggctg tgatgagcag acatcctctg     4440

tccccgtgga ggggtcaaca ccaaggtggt gttcgtgcac cagaacctgt ctcgggctga     4500

cgggggtggc acacaggaca cgggtggatc ccaacaggca gcaccgcacc tctgcccgcc     4560

tcccgcactg cagctccgcc cgccgggctc tgcgtcccca cgtcccctcg tcccatcccc     4620

acgtcccctc atcccgtcac ctcgtcccca catccccttg ccccgtcacc tcgtcctcat     4680

gtccccttgt cctgtcacct cgtccccacg tcccctcgtc tcctcatccc cacgtcctct     4740

cgtccccttg tcccgtcccc acataccctc gtccccatgt ccccacgcag ggctctcctt     4800

cgtcttagga tctgtccagc gctgctctgg gtgggttagc aaccccaggg ctgctgtgat     4860

aggaagtccc tgttgttctc cgtactggca tttctatttc tagaaataat atttgacata     4920

gccttaatgg tccttaaaga agacatttca gtgtgagatt cagacttcag acgctgaaac     4980

tgctgccttt caggaaagca ccaccaacgc tggaggagga gccggccctc acgcccgccc     5040

cgcgccacgc tgtggaacgg ggctccggca agtgaaaccc agagggtgtt tccgaggtgc     5100

tcgacagtag gtatttttgg aagctcagat ttcaccattt gattgtataa tcttttacct     5160

ataaaatatt tatttgaagt agagggtaaa tcagcggtaa gaacagtgaa cacagtggtt     5220

gggataaaat aaggtgacaa acatcacacc aaagatgagg gtagcgagca actggcttga     5280

gcagacagaa cggggaagac tccactctgt cccgaggggc cagccgcagg cgtccccagg     5340

gccaccctgc cctgaggtcc ttgtgtggcc gccctggctt ggcagccctg cccacgctgc     5400

ccccgcaaac aatggtgtgt gcgtttttac agcccttttt aggaacccaa tatgggcata     5460

aatgtaacac ctgtagcggg ggcagattct ctgtatgttc agttaacaaa ttatttgtaa     5520

tgtatttttt tagaaatctt aaaattgcct ttgcactgaa gtattttcat agctgtttat     5580

atctctttta ttcatttatt taacatactg tctaatttta aaaataggtt tttaaagctt     5640

tcatttttaa gtttatgaaa ttttggccac tttacattta gattctggtg agagttttga     5700

ctgaatgttc caatctctga tgaatgcgaa ttttcagatt tgattttatt ctctacacac     5760

acctcttctt ttcttggtat ttctggtggc agtgattagt tgaacagcac atttaaggca     5820

cgataatttg ctacactttt tctttacaat ttgttgcaat ttcatctgct ttctatgttt     5880

cattgttaat tgccatcctt cagccttaaa aatagaagat tctcacgtga aggtttagta     5940

agttgggtcc cagctctgcc tgtgtggaga tagtcaccat gtacctctga caacaagttt     6000

tagtgtgaaa gtcactaaac ttttacacac tcccaaacgt ctttttaaaa attgcttggg     6060

aaattattaa atgaatgtgc ctgatgattt gaaatagaca aggggcacga gataaaaaag     6120

aaaaggatga gaagatcctc agtgaatgac gttgcagggt cttcatgcaa ttttccacct     6180

cgcagtagtt agtatttact tgccttaaac taactttgaa gcaagtaatg tcaactttga     6240

gcactttgtt gagttttgaa aaatcttatt tgttgctgca caggttaata aattatcaat     6300

ttgtaattca gcatgttggt cagagacacg gtcactgatt cacacccagt ccctgccaca     6360

gaccgtctca gacacgcaca gtgggcctgc tgcatgattc acacccagtc cctgccacag     6420

accgtctcag acacgcacag tgggcctgct gcatgattca cacccagtcc ctgccacaga     6480

ccgtctcaga cacgcacagt gggcctgctg catgcgtgtt acctggcttt tggctccacg     6540

ctcactcata gccatgtcca catgggggct tgcacacagg atcactcaca tatgtacatg     6600

tacccaccac aaacgtgcaa gctcctgcac acatgcatgc acacaaacgt gtacacaagt     6660

gtgagctcct acacgcatac acacacacac gtgtacatgc accaaagcat gtgtgaccta     6720

cagacatgca gaacatgcac gtgtacacat accacagaca cgcgtgtgca tgctcctaca     6780

caatacatat gcacatatca tgaacagcgt aagttcctac acacggacgt gtgatacaca     6840

catgcatgta caggtaagca cacatgtaca agctcctaca ggcttgctct cacacacgtg     6900

tatgcacagc agagagacgt atgagcttct actgcacaca tgcacacaca cacgcacacg     6960

tacattcact acaaacgtgc agcctcctgc acacgtgcac attcatgtgt acaccacaaa     7020

tgagttccca gacgtgtaaa cacacgtgca cacatcgtac acatgtgagc tcccacacgt     7080

acacacagat gcacatggac acaccccaaa cacgcacagg ctcctacaca catgcacaca     7140

cgtgtacacc acaaacgagc tcccagacat gtaaacacac gtctcccaca cgtgagctcc     7200

cacacgtaca catgcacatg tacgcaccac aaacacatgc gcaggctcct gcaggcgtga     7260

atacacacat gcacacacat atacacacat gtgccacaaa caagtgcaca ctgtcctggt     7320

gtcctgcact gcatcctgcc tccttgctga ggggcccctg tgagaggcct ctggatgggc     7380

atgggaagat gggctccctg gcccccagcc catgcctccc tgggatgaag agtccccctc     7440

ctggcagaat gtctgggctt tgcagagcag gccccggggg tgaagtcgca gcttcactta     7500

caccagctgc tctgtgagca aggcttggtg ccctggacaa ggcccttccc ctttagggag     7560

gtccagcctc gcaagctgaa acctcccctc ggctcagccc tataccaggc ggccacagca     7620

ggactggcca cacccacgcc gcacctcatc cgtgcacgcg tcggagcacg gccagccttc     7680

cgccacgagc cagctgggaa gggccgcggc cgcctaaagc cccagtcaac ccagcctgtg     7740

tctgagcaga cagggcgaac aagcaggcca caccgtctcg agggaggagg ccagatgcgg     7800

ccagcgtctc caacagggtg accatccgct cggcttgctg agcgtttaaa caaatgttta     7860

gacaggctgt ggggactccc ctgagttgag ccttggccag gggtccggtg ctgtcgcggg     7920

aaacctccag ccttgttctt caaaccactc agctcatgtg ttttgcactg actagtactg     7980

aataatacaa ccactcttat ttaatgttag tattatttat ttgacaactc agtgtctaac     8040

agcttgatat gcaggtcctt gcatcctaca tttctttagg aagttaccca tttgtaactt     8100

taaaaacagg aaaaatatca gttggcaaat gcaatctttt ttttttttaa gctaaaggtg     8160

ggtgaactgg aatgaaaatc tttctgatgt tgtgtctata agcagccttg atgggatatg     8220

ttagaagtgt catgaaagtg tgattctact tttgcagaaa aatctaaaga tcaatttata     8280

tagctttatt ttttacttta tcaaagtata cagaatttta atatgcatat attgtgtctg     8340

acttaaaatt ataatgtctg cgtcaccatt taaaatgtct gttcattatg taatgtaata     8400

aaagaaggtc ttcaaaaatg tatttaacat gaatggtatc catagttgtc atcatcataa     8460

atactggagt ttatttttaa attattaaac atagtaggtg cattaacata aatcagtctc     8520

cacacagtaa catttaactg ataattcatt aatcagcttt gaaaaattaa attgttaatt     8580

aaaccaatct aacatttcag taaagtttat tttgtatgct tctgttttta acttttattt     8640

ctgtagataa actgactgga taatattata ttggactttt ctctagatta tctaagcagg     8700

agacctgaat ctgcttgcaa taaagaataa aagtctgctt cagtttcttt ataaagaaac     8760

tcacacaa                                                              8768


<210>  49
<211>  1191
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asp Cys Ser Leu Val Arg Thr Leu Val His Arg Tyr Cys Ala Gly 
1               5                   10                  15      


Glu Glu Asn Trp Val Asp Ser Arg Thr Ile Tyr Val Gly His Arg Glu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Ala Tyr Ile Pro Gln Arg Tyr Pro Asp Asn 
        35                  40                  45              


Arg Ile Val Ser Ser Lys Tyr Thr Phe Trp Asn Phe Ile Pro Lys Asn 
    50                  55                  60                  


Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile 
65                  70                  75                  80  


Phe Leu Val Gln Leu Ile Ile Asp Thr Pro Thr Ser Pro Val Thr Ser 
                85                  90                  95      


Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly 
            100                 105                 110         


Tyr Glu Asp Trp Leu Arg His Lys Ala Asp Asn Ala Met Asn Gln Cys 
        115                 120                 125             


Pro Val His Phe Ile Gln His Gly Lys Leu Val Arg Lys Gln Ser Arg 
    130                 135                 140                 


Lys Leu Arg Val Gly Asp Ile Val Met Val Lys Glu Asp Glu Thr Phe 
145                 150                 155                 160 


Pro Cys Asp Leu Ile Phe Leu Ser Ser Asn Arg Gly Asp Gly Thr Cys 
                165                 170                 175     


His Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Ser His Lys Thr His 
            180                 185                 190         


Tyr Ala Val Gln Asp Thr Lys Gly Phe His Thr Glu Glu Asp Ile Gly 
        195                 200                 205             


Gly Leu His Ala Thr Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr 
    210                 215                 220                 


Lys Phe Val Gly Arg Ile Asn Val Tyr Ser Asp Leu Asn Asp Pro Val 
225                 230                 235                 240 


Val Arg Pro Leu Gly Ser Glu Asn Leu Leu Leu Arg Gly Ala Thr Leu 
                245                 250                 255     


Lys Asn Thr Glu Lys Ile Phe Gly Val Ala Ile Tyr Thr Gly Met Glu 
            260                 265                 270         


Thr Lys Met Ala Leu Asn Tyr Gln Ser Lys Ser Gln Lys Arg Ser Ala 
        275                 280                 285             


Val Glu Lys Ser Met Asn Ala Phe Leu Ile Val Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Ile Ser Lys Ala Leu Ile Asn Thr Val Leu Lys Tyr Met Trp Gln Ser 
305                 310                 315                 320 


Glu Pro Phe Arg Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu Ser Glu 
                325                 330                 335     


Arg Gln Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe 
            340                 345                 350         


Met Val Leu Phe Asn Tyr Ile Ile Pro Val Ser Met Tyr Val Thr Val 
        355                 360                 365             


Glu Met Gln Lys Phe Leu Gly Ser Tyr Phe Ile Thr Trp Asp Glu Asp 
    370                 375                 380                 


Met Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp 
385                 390                 395                 400 


Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Ile Phe Thr Asp Lys Thr 
                405                 410                 415     


Gly Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys Ile Glu 
            420                 425                 430         


Gly His Val Tyr Val Pro His Val Ile Cys Asn Gly Gln Val Leu Pro 
        435                 440                 445             


Glu Ser Ser Gly Ile Asp Met Ile Asp Ser Ser Pro Ser Val Asn Gly 
    450                 455                 460                 


Arg Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr 
465                 470                 475                 480 


Val Gln Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro 
                485                 490                 495     


Asp Gly Gly Lys Ser Cys Val Tyr Ile Ser Ser Ser Pro Asp Glu Val 
            500                 505                 510         


Ala Leu Val Glu Gly Val Gln Arg Leu Gly Phe Thr Tyr Leu Arg Leu 
        515                 520                 525             


Lys Asp Asn Tyr Met Glu Ile Leu Asn Arg Glu Asn His Ile Glu Arg 
    530                 535                 540                 


Phe Glu Leu Leu Glu Ile Leu Ser Phe Asp Ser Val Arg Arg Arg Met 
545                 550                 555                 560 


Ser Val Ile Val Lys Ser Ala Thr Gly Glu Ile Tyr Leu Phe Cys Lys 
                565                 570                 575     


Gly Ala Asp Ser Ser Ile Phe Pro Arg Val Ile Glu Gly Lys Val Asp 
            580                 585                 590         


Gln Ile Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr 
        595                 600                 605             


Leu Cys Val Ala Tyr Lys Arg Leu Ile Gln Glu Glu Tyr Glu Gly Ile 
    610                 615                 620                 


Cys Lys Leu Leu Gln Ala Ala Lys Val Ala Leu Gln Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Leu Ala Glu Ala Tyr Glu Gln Ile Glu Lys Asp Leu Thr Leu Leu 
                645                 650                 655     


Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Glu Lys Ala Ala Asp Thr 
            660                 665                 670         


Ile Glu Ala Leu Gln Lys Ala Gly Ile Lys Val Trp Val Leu Thr Gly 
        675                 680                 685             


Asp Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe 
    690                 695                 700                 


Arg Arg Asn Thr Gln Leu Leu Glu Leu Thr Thr Lys Arg Ile Glu Glu 
705                 710                 715                 720 


Gln Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg 
                725                 730                 735     


His Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp 
            740                 745                 750         


Met Gln Asp Tyr Gly Leu Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile 
        755                 760                 765             


Met Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe 
    770                 775                 780                 


Leu Glu Ile Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala 
785                 790                 795                 800 


Pro Leu Gln Lys Ala Gln Ile Val Lys Leu Ile Lys Phe Ser Lys Glu 
                805                 810                 815     


His Pro Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met 
            820                 825                 830         


Ile Leu Glu Ala His Val Gly Ile Gly Val Ile Gly Lys Glu Gly Arg 
        835                 840                 845             


Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Pro Lys Phe Lys His Leu 
    850                 855                 860                 


Lys Lys Met Leu Leu Val His Gly His Phe Tyr Tyr Ile Arg Ile Ser 
865                 870                 875                 880 


Glu Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Phe Pro 
                885                 890                 895     


Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Thr Leu Tyr 
            900                 905                 910         


Asp Thr Ala Tyr Leu Thr Leu Tyr Asn Ile Ser Phe Thr Ser Leu Pro 
        915                 920                 925             


Ile Leu Leu Tyr Ser Leu Met Glu Gln His Val Gly Ile Asp Val Leu 
    930                 935                 940                 


Lys Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu 
945                 950                 955                 960 


Arg Trp Arg Val Phe Ile Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala 
                965                 970                 975     


Leu Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val 
            980                 985                 990         


Thr Ser Asn Gly Gln Ile Phe Gly  Asn Trp Thr Phe Gly  Thr Leu Val 
        995                 1000                 1005             


Phe Thr  Val Met Val Phe Thr  Val Thr Leu Lys Leu  Ala Leu Asp 
    1010                 1015                 1020             


Thr His  Tyr Trp Thr Trp Ile  Asn His Phe Val Ile  Trp Gly Ser 
    1025                 1030                 1035             


Leu Leu  Phe Tyr Val Val Phe  Ser Leu Leu Trp Gly  Gly Val Ile 
    1040                 1045                 1050             


Trp Pro  Phe Leu Asn Tyr Gln  Arg Met Tyr Tyr Val  Phe Ile Gln 
    1055                 1060                 1065             


Met Leu  Ser Ser Gly Pro Ala  Trp Leu Ala Ile Val  Leu Leu Val 
    1070                 1075                 1080             


Thr Ile  Ser Leu Leu Pro Asp  Val Leu Lys Lys Val  Leu Cys Arg 
    1085                 1090                 1095             


Gln Leu  Trp Pro Thr Ala Thr  Glu Arg Val Gln Asn  Gly Cys Ala 
    1100                 1105                 1110             


Gln Pro  Arg Asp Arg Asp Ser  Glu Phe Thr Pro Leu  Ala Ser Leu 
    1115                 1120                 1125             


Gln Ser  Pro Gly Tyr Gln Ser  Thr Cys Pro Ser Ala  Ala Trp Tyr 
    1130                 1135                 1140             


Ser Ser  His Ser Gln Gln Val  Thr Leu Ala Ala Trp  Lys Glu Lys 
    1145                 1150                 1155             


Val Ser  Thr Glu Pro Pro Pro  Ile Leu Gly Gly Ser  His His His 
    1160                 1165                 1170             


Cys Ser  Ser Ile Pro Ser His  Ser Cys Pro Arg Ser  Arg Val Gly 
    1175                 1180                 1185             


Met Leu  Val 
    1190     


<210>  50
<211>  4673
<212>  DNA
<213>  Homo sapiens

<400>  50
tttccgcagt taggggctgc tatttcaacg cagggagata aaaagaaaaa aacacttgct       60

cttctacccc gctaaaaaca ctcatcctag ggagcacgcc agcatttgca gcgttcgggg      120

cagggccact cggcctgcgg ccgttgcact ggctggaagc tggcaggcga tcacggttga      180

ttggctcggg tgcggtccaa gggcagcaac gccttcggcg ggccgcctag ggtgattggc      240

tgctgcagcc caccccctag ccggtttggt gggcggcgaa gcctggattg gtggagctaa      300

gagctggctc agtttcagcg ctggctcttc gtgcatggca gagatggcga ctgcgactcg      360

gctgctgggg tggcgtgtgg cgagctggag gctgcggccg ccgcttgccg gcttcgtttc      420

ccagcgggcc cactcgcttt tgcccgtgga cgatgcaatc aatgggctaa gcgaggagca      480

gaggcagctt cgtcagacca tggctaagtt ccttcaggag cacctggccc ccaaggccca      540

ggagatcgat cgcagcaatg agttcaagaa cctgcgagaa ttttggaagc agctggggaa      600

cctgggcgta ttgggcatca cagcccctgt tcagtatggc ggctccggcc tgggctacct      660

ggagcatgtg ctggtgatgg aggagatatc ccgagcttcc ggagcagtgg ggctcagtta      720

cggtgcccac tccaacctct gcatcaacca gcttgtacgc aatgggaatg aggcccagaa      780

agagaagtat ctcccgaagc tgatcagtgg tgagtacatc ggagccctgg ccatgagtga      840

gcccaatgca ggctctgatg ttgtctctat gaagctcaaa gcggaaaaga aaggaaatca      900

ctacatcctg aatggcaaca agttctggat cactaatggc cctgatgctg acgtcctgat      960

tgtctatgcc aagacagatc tggctgctgt gccagcttct cggggcatca cagccttcat     1020

tgtggagaag ggtatgcctg gctttagcac ctctaagaag ctggacaagc tggggatgag     1080

gggctctaac acctgtgagc taatctttga agactgcaag attcctgctg ccaacatcct     1140

gggccatgag aataagggtg tctacgtgct gatgagtggg ctggacctgg agcggctggt     1200

gctggccggg gggcctcttg ggctcatgca agcggtcctg gaccacacca ttccctacct     1260

gcacgtgagg gaagcctttg gccagaagat cggccacttc cagttgatgc aggggaagat     1320

ggctgacatg tacacccgcc tcatggcgtg tcggcagtat gtctacaatg tcgccaaggc     1380

ctgcgatgag ggccattgca ctgctaagga ctgtgcaggt gtgattcttt actcagctga     1440

gtgtgccaca caggtagccc tggacggcat tcagtgtttt ggtggcaatg gctacatcaa     1500

tgactttccc atgggccgct ttcttcgaga tgccaagctg tatgagatag gggctgggac     1560

cagcgaggtg aggcggctgg tcatcggcag agccttcaat gcagactttc actagtcctg     1620

agacccttcg cccccttttc ctgcacctag tggcctttct tgggaagtag agatgtggcg     1680

gctttcccac cctgcccaca gcaggccctc ctgcccagct gctcttgtca gccctctggc     1740

ctctggatga ggttgagttc tccacaacag ctcccaagca tcatgggcct cgcagccggg     1800

cctgtgccac ggctagtgtt gtgtgattta aaatggactc agcaggaagc atattgtctg     1860

gggattgttg ggacaggttt tggtgactct gtgcccttgc tctctaactt ctgagcccac     1920

ctcccagggt aggcacctgg gggcatgcag gtgcccacct cccagggtag gcacctgggg     1980

gcatgcaggt acccacctct ttctcttggg tgaggctctg gcaaggagat ctctctgctc     2040

aagcacagca gaatcatggc ccctctccat gaattggaac ttggtacagg ttaagtatcc     2100

ctaatcctga aatctgaaac acttgtggtt ccaagcattt tggataaggc aaattcaact     2160

ttcagtctct tttctggggg aaaaaaataa taaacctagc ctagccaggc gtggtggctc     2220

atgcttgtaa tcccagcact tcaggaggct gagatgggtg gatcacctga ggtcaggagt     2280

tcaagaccag cctggccaac atgtggaaac ctcgcctcaa ctaaaaatag aaaaaaatta     2340

gttgggcatg gtggtgggca cctgtaatcc cagctacttc aggaggctga ggcaggagaa     2400

ttacttgaac ccaggaggcg gacgttgcag tgagccgagc ttgtgccatt gcactccagc     2460

ctgggcgaca agagcaaaac tcttcaaaaa acaaaacaaa acaaaaaaac cctggccctt     2520

gtttcttcca gtttctagag gtatcagctc ctagcagctt atgaacacat atgcttgctt     2580

ggccaggcaa ggtggtgtgt gcctgtaatc ccagcacttt gggaggccaa ggcaggtgga     2640

tcacttgcag tcaggagttc aagaccagcc tgtccaacgt ggtgaaaccc catctctact     2700

aaaaatacaa aaattagcca ggggtggtgg tgcacgtctg taatcccagc tactcaggag     2760

gctgaggcag gagaatcact tgaacccggg aggtggaggt tgcaatgagc caatatgaca     2820

ccgctgcagt ccagcctggg ccatagagtg agactctgtc tcaaaaaagg aaagaaaaat     2880

aggctgggca cagtgactca tgcctgtaat cccaacactt tgggaggccg aggcaggtgg     2940

atcacgaggt caggagttca agaccagcct ggccaagatg gtaaaacctc gtctctacta     3000

aaaatacaaa aattagccag gtgtggtggc aggctcctgt aatcccagct actcaggagg     3060

ctgaggcaga gaattgcttg aacccgggag gcagagtttg cagtgagcca agatcacacc     3120

actgcactcc agcttggacg acagagcgag actctgtctc aaaaaataat aggccaggca     3180

tggtggctca acgtctgtaa tcccagcact ttgggaggcc gaggcgggca gatcacaagg     3240

tcaggagttc gagaccagcc tgacgaccaa catggtgaaa cctcgtctct actaaaaata     3300

caaaaattag ccaggcctgg tggcacgcgc ctgtaatccc agttacacag aagactgagg     3360

caggagaatc gcttgaacgc aggaggcaga ggttgcagga gctgagatcg cgccattgca     3420

ctccagcctg ggcaacagag tgagactctg tctcaaaaaa taataataaa ataaatgaac     3480

acacatgctg ctgagtccgc agggggggca gagcagagga cagcgtgctt ttgtgtactg     3540

ttggaagact ggctcctcct gtacagcacc tctgagccct tgtgcaccgc cctgccacgg     3600

gcaccatcca gtcctggccg tgtgaccacc cacagctgac tgggcagcag gcacaggccc     3660

tacccgagca ggccggagtt ggctcgcatg actccagctg aggctgcctg tgtacatttc     3720

tccagatacc ctatggctaa ttttgttata actgcacagt ggctgctgcc attttgtatt     3780

aaatatattg tgaaacaaac ctatctgggg agaagcaatc tacttgccgc tgcttcctgt     3840

ctggatccag cttgtgtcct tggagagtgg ctggcccagg tcctattcct gtcctccagc     3900

ccgttctttc atgagggaca ggaaggtaaa atcagccctt aggagagagg tctcagcctc     3960

cctttcccag atctcccagt gagttttaaa ggaagcaggg agcccagagt gctaagttct     4020

tacagccaga aggaagctta tagatttctg aaaaccgccc ctttgttttt aaaaagatca     4080

acacaatttg actttctcaa ggtcaaaacg aactagaatc cagatctgct catggcaaaa     4140

atgggggtgt tctgagaatt ccagctttgg gccgcactgt acagcagtct ggatagagtg     4200

tgatctgaga agggaatggg tctgggttgt tccacccctt ccgagttcca aaaagaggga     4260

actggttttc ttggttctca gcccagcagc acctatcctg gctcttggtc ctggcctgca     4320

gccaagtgct gttcctagcc tgaggcttga gacaggtggg gttggctcct caccaacccc     4380

agttccgtcc catcctgagg gcaagatcct gggctcatag gcagtccctt tcacttcctt     4440

gtcttgctcc ctgctatgtt ggagatgaat gtgactaaaa gggccatctt gctggcttaa     4500

tgtgtggctg gagagaccag cctggagaca atgtggcaaa atggggcgct tcatccagtc     4560

tgtctaagcc ctgtcgactt ggggaggtga tttctttcct ggttctatat gtgaagcaaa     4620

ataaatgttt taaaattaaa agcaaaaaaa acaaaatgaa ccatgaaaaa aaa            4673


<210>  51
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Glu Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala 
1               5                   10                  15      


Ser Trp Arg Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala 
            20                  25                  30          


His Ser Leu Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu 
        35                  40                  45              


Gln Arg Gln Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu 
    50                  55                  60                  


Ala Pro Lys Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu 
65                  70                  75                  80  


Arg Glu Phe Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr 
                85                  90                  95      


Ala Pro Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val 
            100                 105                 110         


Leu Val Met Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser 
        115                 120                 125             


Tyr Gly Ala His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly 
    130                 135                 140                 


Asn Glu Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu 
145                 150                 155                 160 


Tyr Ile Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val 
                165                 170                 175     


Val Ser Met Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu 
            180                 185                 190         


Asn Gly Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu 
        195                 200                 205             


Ile Val Tyr Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly 
    210                 215                 220                 


Ile Thr Ala Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser 
225                 230                 235                 240 


Lys Lys Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu 
                245                 250                 255     


Ile Phe Glu Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu 
            260                 265                 270         


Asn Lys Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu 
        275                 280                 285             


Val Leu Ala Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His 
    290                 295                 300                 


Thr Ile Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly 
305                 310                 315                 320 


His Phe Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu 
                325                 330                 335     


Met Ala Cys Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu 
            340                 345                 350         


Gly His Cys Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala 
        355                 360                 365             


Glu Cys Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly 
    370                 375                 380                 


Asn Gly Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala 
385                 390                 395                 400 


Lys Leu Tyr Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val 
                405                 410                 415     


Ile Gly Arg Ala Phe Asn Ala Asp Phe His 
            420                 425     


<210>  52
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Gly Lys His Tyr Lys Gly Pro Glu Val Ser Cys Cys Ile Lys 
1               5                   10                  15      


Tyr Phe Ile Phe Gly Phe Asn Val Ile Phe Trp Phe Leu Gly Ile Thr 
            20                  25                  30          


Phe Leu Gly Ile Gly Leu Trp Ala Trp Asn Glu Lys Gly Val Leu Ser 
        35                  40                  45              


Asn Ile Ser Ser Ile Thr Asp Leu Gly Gly Phe Asp Pro Val Trp Leu 
    50                  55                  60                  


Phe Leu Val Val Gly Gly Val Met Phe Ile Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80  


Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe Ser Val 
                85                  90                  95      


Phe Leu Gly Ile Ile Phe Phe Leu Glu Leu Thr Ala Gly Val Leu Ala 
            100                 105                 110         


Phe Val Phe Lys Asp Trp Ile Lys Asp Gln Leu Tyr Phe Phe Ile Asn 
        115                 120                 125             


Asn Asn Ile Arg Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
    130                 135                 140                 


Asp Phe Thr Gln Glu Tyr Trp Gln Cys Cys Gly Ala Phe Gly Ala Asp 
145                 150                 155                 160 


Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Ser Asn Ala Ser 
                165                 170                 175     


Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Thr Lys Asp Pro Ala 
            180                 185                 190         


Glu Asp Val Ile Asn Thr Gln Cys Gly Tyr Asp Ala Arg Gln Lys Pro 
        195                 200                 205             


Glu Val Asp Gln Gln Ile Val Ile Tyr Thr Lys Gly Cys Val Pro Gln 
    210                 215                 220                 


Phe Glu Lys Trp Leu Gln Asp Asn Leu Thr Ile Val Ala Gly Ile Phe 
225                 230                 235                 240 


Ile Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn 
                245                 250                 255     


Leu Val Ser Asp Ile Glu Ala Val Arg Ala Ser Trp 
            260                 265             


<210>  53
<211>  3583
<212>  DNA
<213>  Homo sapiens

<400>  53
ctgggcccca gcgaggcggt ggggcggggc ggggcggggc ggggcgcgca gcaggagcga       60

gtggggccgc ccgccgggcc gcggacactg tcgcccggcg cccaggttcc caacaaggct      120

acgcagaaga acccccttga ctgaagcaat ggaggggggt ccagctgtct gctgccagga      180

tcctcgggca gagctggtag aacgggtggc agccatcgat gtgactcact tggaggaggc      240

agatggtggc ccagagccta ctagaaacgg tgtggacccc ccaccacggg ccagagctgc      300

ctctgtgatc cctggcagta cttcaagact gctcccagcc cggcctagcc tctcagccag      360

gaagctttcc ctacaggagc ggccagcagg aagctatctg gaggcgcagg ctgggcctta      420

tgccacgggg cctgccagcc acatctcccc ccgggcctgg cggaggccca ccatcgagtc      480

ccaccacgtg gccatctcag atgcagagga ctgcgtgcag ctgaaccagt acaagctgca      540

gagtgagatt ggcaagggtg cctacggtgt ggtgaggctg gcctacaacg aaagtgaaga      600

cagacactat gcaatgaaag tcctttccaa aaagaagtta ctgaagcagt atggctttcc      660

acgtcgccct cccccgagag ggtcccaggc tgcccaggga ggaccagcca agcagctgct      720

gcccctggag cgggtgtacc aggagattgc catcctgaag aagctggacc acgtgaatgt      780

ggtcaaactg atcgaggtcc tggatgaccc agctgaggac aacctctatt tggtgtttga      840

cctcctgaga aaggggcccg tcatggaagt gccctgtgac aagcccttct cggaggagca      900

agctcgcctc tacctgcggg acgtcatcct gggcctcgag tacttgcact gccagaagat      960

cgtccacagg gacatcaagc catccaacct gctcctgggg gatgatgggc acgtgaagat     1020

cgccgacttt ggcgtcagca accagtttga ggggaacgac gctcagctgt ccagcacggc     1080

gggaacccca gcattcatgg cccccgaggc catttctgat tccggccaga gcttcagtgg     1140

gaaggccttg gatgtatggg ccactggcgt cacgttgtac tgctttgtct atgggaagtg     1200

cccattcatc gacgatttca tcctggccct ccacaggaag atcaagaatg agcccgtggt     1260

gtttcctgag gagccagaaa tcagcgagga gctcaaggac ctgatcctga agatgttaga     1320

caagaatccc gagacgagaa ttggggtgcc agacatcaag ttgcaccctt gggtgaccaa     1380

gaacggggag gagccccttc cttcggagga ggagcactgc agcgtggtgg aggtgacaga     1440

ggaggaggtt aagaactcag tcaggctcat ccccagctgg accacggtga tcctggtgaa     1500

gtccatgctg aggaagcgtt cctttgggaa cccgtttgag ccccaagcac ggagggaaga     1560

gcgatccatg tctgctccag gaaacctact ggtgaaagaa gggtttggtg aagggggcaa     1620

gagcccagag ctccccggcg tccaggaaga cgaggctgca tcctgagccc ctgcatgcac     1680

ccagggccac ccggcagcac actcatcccg cgcctccaga ggcccacccc tcatgcaaca     1740

gccgcccccg caggcagggg gctggggact gcagccccac tcccgcccct cccccatcgt     1800

gctgcatgac ctccacgcac gcacgtccag ggacagactg gaatgtatgt catttggggt     1860

cttgggggca gggctcccac gaggccatcc tcctcttctt ggacctcctt ggcctgaccc     1920

attctgtggg gaaaccgggt gcccatggag cctcagaaat gccacccggc tggttggcat     1980

ggcctggggc aggaggcaga ggcaggagac caagatggca ggtggaggcc aggcttacca     2040

caacggaaga gacctcccgc tggggccggg caggcctggc tcagctgcca caggcatatg     2100

gtggagaggg gggtaccctg cccaccttgg ggtggtggca ccagagctct tgtctattca     2160

gacgctggta tgggggctcg gacccctcac tggggacagg gccagtgttg gagaattctg     2220

attccttttt tgttgtcttt tacttttgtt tttaacctgg gggttcgggg agaggccctg     2280

cttgggaaca tctcacgagc tttcctacat cttccgtggt tcccagcaca gcccaagatt     2340

atttggcagc caagtggatg gaactaactt tcctggactg tgtttcgcat tcggcgttat     2400

ctggaaagtg gactgaacgg aatcaagctc tgagcagagg cctgaagcgg aagcaccaca     2460

tcgtccctgc ccatctcact ctctcccttg atgatgcccc tagagctgag gctggagaag     2520

acaccagggc tgactttgac cgagggccat ggacgcgaca ggcctgtggc cctgcgcatg     2580

ctgaaataac tggaacccag cctctcctcc tacaccggcc tacccatctg ggcccaagag     2640

ctgcactcac actcctacaa cgaaggacaa actgtccagg tcggagggat cacgagacac     2700

agaacctgga ggggtgtgca cgctggcagg tggcctctgc ggcaattgcc tcaccctgag     2760

gacatcagca gtcagcctgc tcagagcggg ggtgctggag cgcgtgcaga cacagctctt     2820

ccggagcagc cttcaccttc tctctgggat cagtgtccgg ctggccgacg tggcatttgc     2880

tgaccgaatg ctcatagagg ttgaccccca cagggtcacg caggactcgg acactgccct     2940

ggaaacatgg atggacaagg gcttttggcc acaggtgtgg gtgtcctgtt ggaggagggc     3000

ttgtttggag aagggaggct ggctggggga gaaacccgga tcccgctgca tctccgcgcc     3060

tgtgggtgca tgtcgcgtgc tcatctgttg cacacagctc actcgtatgt cctgcactgg     3120

tacatgcatc tgtaatacag tttctacgtc tatttaaggc taggagccga atgtgcccca     3180

ttgtcagtgg gtccacgttt ctccccggct cctctgggct aaggcagtgt ggcccgaagc     3240

ttaaaaagtt actcggtact gtttttaaga acacttttat agagttagtg gaaggcaagt     3300

taagagccaa tcactgatcc ccaagtgttt cttgagcatc tggtctgggg ggaccacttt     3360

gatcggaccc acccttggaa agctcagggg taggcccagg tgggatgctc accctgtcac     3420

tgagggtttt ggttggcatc gttgtttttg aatgtagcac aagcgatgag caaactctat     3480

aagagtgttt taaaaattaa cttcccagga agtgagttaa aaacaataaa agccctttct     3540

tgagttaaaa agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       3583


<210>  54
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210>  55
<211>  3529
<212>  DNA
<213>  Homo sapiens

<400>  55
agcagaacag agtatgcaat ttgggaagct gtggtgtggc tgcagtggag agttcccaac       60

aaggctacgc agaagaaccc ccttgactga agcaatggag gggggtccag ctgtctgctg      120

ccaggatcct cgggcagagc tggtagaacg ggtggcagcc atcgatgtga ctcacttgga      180

ggaggcagat ggtggcccag agcctactag aaacggtgtg gaccccccac cacgggccag      240

agctgcctct gtgatccctg gcagtacttc aagactgctc ccagcccggc ctagcctctc      300

agccaggaag ctttccctac aggagcggcc agcaggaagc tatctggagg cgcaggctgg      360

gccttatgcc acggggcctg ccagccacat ctccccccgg gcctggcgga ggcccaccat      420

cgagtcccac cacgtggcca tctcagatgc agaggactgc gtgcagctga accagtacaa      480

gctgcagagt gagattggca agggtgccta cggtgtggtg aggctggcct acaacgaaag      540

tgaagacaga cactatgcaa tgaaagtcct ttccaaaaag aagttactga agcagtatgg      600

ctttccacgt cgccctcccc cgagagggtc ccaggctgcc cagggaggac cagccaagca      660

gctgctgccc ctggagcggg tgtaccagga gattgccatc ctgaagaagc tggaccacgt      720

gaatgtggtc aaactgatcg aggtcctgga tgacccagct gaggacaacc tctatttggt      780

gtttgacctc ctgagaaagg ggcccgtcat ggaagtgccc tgtgacaagc ccttctcgga      840

ggagcaagct cgcctctacc tgcgggacgt catcctgggc ctcgagtact tgcactgcca      900

gaagatcgtc cacagggaca tcaagccatc caacctgctc ctgggggatg atgggcacgt      960

gaagatcgcc gactttggcg tcagcaacca gtttgagggg aacgacgctc agctgtccag     1020

cacggcggga accccagcat tcatggcccc cgaggccatt tctgattccg gccagagctt     1080

cagtgggaag gccttggatg tatgggccac tggcgtcacg ttgtactgct ttgtctatgg     1140

gaagtgccca ttcatcgacg atttcatcct ggccctccac aggaagatca agaatgagcc     1200

cgtggtgttt cctgaggagc cagaaatcag cgaggagctc aaggacctga tcctgaagat     1260

gttagacaag aatcccgaga cgagaattgg ggtgccagac atcaagttgc acccttgggt     1320

gaccaagaac ggggaggagc cccttccttc ggaggaggag cactgcagcg tggtggaggt     1380

gacagaggag gaggttaaga actcagtcag gctcatcccc agctggacca cggtgatcct     1440

ggtgaagtcc atgctgagga agcgttcctt tgggaacccg tttgagcccc aagcacggag     1500

ggaagagcga tccatgtctg ctccaggaaa cctactggtg aaagaagggt ttggtgaagg     1560

gggcaagagc ccagagctcc ccggcgtcca ggaagacgag gctgcatcct gagcccctgc     1620

atgcacccag ggccacccgg cagcacactc atcccgcgcc tccagaggcc cacccctcat     1680

gcaacagccg cccccgcagg cagggggctg gggactgcag ccccactccc gcccctcccc     1740

catcgtgctg catgacctcc acgcacgcac gtccagggac agactggaat gtatgtcatt     1800

tggggtcttg ggggcagggc tcccacgagg ccatcctcct cttcttggac ctccttggcc     1860

tgacccattc tgtggggaaa ccgggtgccc atggagcctc agaaatgcca cccggctggt     1920

tggcatggcc tggggcagga ggcagaggca ggagaccaag atggcaggtg gaggccaggc     1980

ttaccacaac ggaagagacc tcccgctggg gccgggcagg cctggctcag ctgccacagg     2040

catatggtgg agaggggggt accctgccca ccttggggtg gtggcaccag agctcttgtc     2100

tattcagacg ctggtatggg ggctcggacc cctcactggg gacagggcca gtgttggaga     2160

attctgattc cttttttgtt gtcttttact tttgttttta acctgggggt tcggggagag     2220

gccctgcttg ggaacatctc acgagctttc ctacatcttc cgtggttccc agcacagccc     2280

aagattattt ggcagccaag tggatggaac taactttcct ggactgtgtt tcgcattcgg     2340

cgttatctgg aaagtggact gaacggaatc aagctctgag cagaggcctg aagcggaagc     2400

accacatcgt ccctgcccat ctcactctct cccttgatga tgcccctaga gctgaggctg     2460

gagaagacac cagggctgac tttgaccgag ggccatggac gcgacaggcc tgtggccctg     2520

cgcatgctga aataactgga acccagcctc tcctcctaca ccggcctacc catctgggcc     2580

caagagctgc actcacactc ctacaacgaa ggacaaactg tccaggtcgg agggatcacg     2640

agacacagaa cctggagggg tgtgcacgct ggcaggtggc ctctgcggca attgcctcac     2700

cctgaggaca tcagcagtca gcctgctcag agcgggggtg ctggagcgcg tgcagacaca     2760

gctcttccgg agcagccttc accttctctc tgggatcagt gtccggctgg ccgacgtggc     2820

atttgctgac cgaatgctca tagaggttga cccccacagg gtcacgcagg actcggacac     2880

tgccctggaa acatggatgg acaagggctt ttggccacag gtgtgggtgt cctgttggag     2940

gagggcttgt ttggagaagg gaggctggct gggggagaaa cccggatccc gctgcatctc     3000

cgcgcctgtg ggtgcatgtc gcgtgctcat ctgttgcaca cagctcactc gtatgtcctg     3060

cactggtaca tgcatctgta atacagtttc tacgtctatt taaggctagg agccgaatgt     3120

gccccattgt cagtgggtcc acgtttctcc ccggctcctc tgggctaagg cagtgtggcc     3180

cgaagcttaa aaagttactc ggtactgttt ttaagaacac ttttatagag ttagtggaag     3240

gcaagttaag agccaatcac tgatccccaa gtgtttcttg agcatctggt ctggggggac     3300

cactttgatc ggacccaccc ttggaaagct caggggtagg cccaggtggg atgctcaccc     3360

tgtcactgag ggttttggtt ggcatcgttg tttttgaatg tagcacaagc gatgagcaaa     3420

ctctataaga gtgttttaaa aattaacttc ccaggaagtg agttaaaaac aataaaagcc     3480

ctttcttgag ttaaaaagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 3529


<210>  56
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gln Phe Gly Lys Leu Trp Cys Gly Cys Ser Gly Glu Phe Pro Thr 
1               5                   10                  15      


Arg Leu Arg Arg Arg Thr Pro Leu Thr Glu Ala Met Glu Gly Gly Pro 
            20                  25                  30          


Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu Val Glu Arg Val Ala 
        35                  40                  45              


Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp Gly Gly Pro Glu Pro 
    50                  55                  60                  


Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala Arg Ala Ala Ser Val 
65                  70                  75                  80  


Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala Arg Pro Ser Leu Ser 
                85                  90                  95      


Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala Gly Ser Tyr Leu Glu 
            100                 105                 110         


Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala Ser His Ile Ser Pro 
        115                 120                 125             


Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His His Val Ala Ile Ser 
    130                 135                 140                 


Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr Lys Leu Gln Ser Glu 
145                 150                 155                 160 


Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu Ala Tyr Asn Glu Ser 
                165                 170                 175     


Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser Lys Lys Lys Leu Leu 
            180                 185                 190         


Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro Arg Gly Ser Gln Ala 
        195                 200                 205             


Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro Leu Glu Arg Val Tyr 
    210                 215                 220                 


Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His Val Asn Val Val Lys 
225                 230                 235                 240 


Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp Asn Leu Tyr Leu Val 
                245                 250                 255     


Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu Val Pro Cys Asp Lys 
            260                 265                 270         


Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu Arg Asp Val Ile Leu 
        275                 280                 285             


Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val His Arg Asp Ile Lys 
    290                 295                 300                 


Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His Val Lys Ile Ala Asp 
305                 310                 315                 320 


Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp Ala Gln Leu Ser Ser 
                325                 330                 335     


Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu Ala Ile Ser Asp Ser 
            340                 345                 350         


Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val Trp Ala Thr Gly Val 
        355                 360                 365             


Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro Phe Ile Asp Asp Phe 
    370                 375                 380                 


Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu Pro Val Val Phe Pro 
385                 390                 395                 400 


Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp Leu Ile Leu Lys Met 
                405                 410                 415     


Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val Pro Asp Ile Lys Leu 
            420                 425                 430         


His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro Leu Pro Ser Glu Glu 
        435                 440                 445             


Glu His Cys Ser Val Val Glu Val Thr Glu Glu Glu Val Lys Asn Ser 
    450                 455                 460                 


Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile Leu Val Lys Ser Met 
465                 470                 475                 480 


Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Pro Gln Ala Arg Arg 
                485                 490                 495     


Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu Leu Val Lys Glu Gly 
            500                 505                 510         


Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro Gly Val Gln Glu Asp 
        515                 520                 525             


Glu Ala Ala Ser 
    530         


<210>  57
<211>  2535
<212>  DNA
<213>  Homo sapiens

<400>  57
ctgggcccca gcgaggcggt ggggcggggc ggggcggggc ggggcgcgca gcaggagcga       60

gtggggccgc ccgccgggcc gcggacactg tcgcccggcg cccaggttcc caacaaggct      120

acgcagaaga acccccttga ctgaagcaat ggaggggggt ccagctgtct gctgccagga      180

tcctcgggca gagctggtag aacgggtggc agccatcgat gtgactcact tggaggaggc      240

agatggtggc ccagagccta ctagaaacgg tgtggacccc ccaccacggg ccagagctgc      300

ctctgtgatc cctggcagta cttcaagact gctcccagcc cggcctagcc tctcagccag      360

gaagctttcc ctacaggagc ggccagcagg aagctatctg gaggcgcagg ctgggcctta      420

tgccacgggg cctgccagcc acatctcccc ccgggcctgg cggaggccca ccatcgagtc      480

ccaccacgtg gccatctcag atgcagagga ctgcgtgcag ctgaaccagt acaagctgca      540

gagtgagatt ggcaagggtg cctacggtgt ggtgaggctg gcctacaacg aaagtgaaga      600

cagacactat gcaatgaaag tcctttccaa aaagaagtta ctgaagcagt atggctttcc      660

acgtcgccct cccccgagag ggtcccaggc tgcccaggga ggaccagcca agcagctgct      720

gcccctggag cgggtgtacc aggagattgc catcctgaag aagctggacc acgtgaatgt      780

ggtcaaactg atcgaggtcc tggatgaccc agctgaggac aacctctatt tggccctgca      840

gaaccaggcc cagaatatcc agttagattc aacaaatatc gccaagcccc actccctgct      900

tccctctgag cagcaagaca gtggatccac gtgggctgcg cgctcagtgt ttgacctcct      960

gagaaagggg cccgtcatgg aagtgccctg tgacaagccc ttctcggagg agcaagctcg     1020

cctctacctg cgggacgtca tcctgggcct cgagtacttg cactgccaga agatcgtcca     1080

cagggacatc aagccatcca acctgctcct gggggatgat gggcacgtga agatcgccga     1140

ctttggcgtc agcaaccagt ttgaggggaa cgacgctcag ctgtccagca cggcgggaac     1200

cccagcattc atggcccccg aggccatttc tgattccggc cagagcttca gtgggaaggc     1260

cttggatgta tgggccactg gcgtcacgtt gtactgcttt gtctatggga agtgcccatt     1320

catcgacgat ttcatcctgg ccctccacag gaagatcaag aatgagcccg tggtgtttcc     1380

tgaggagcca gaaatcagcg aggagctcaa ggacctgatc ctgaagatgt tagacaagaa     1440

tcccgagacg agaattgggg tgccagacat caagttgcac ccttgggtga ccaagaacgg     1500

ggaggagccc cttccttcgg aggaggagca ctgcagcgtg gtggaggtga cagaggagga     1560

ggttaagaac tcagtcaggc tcatccccag ctggaccacg gtgatcctgg tgaagtccat     1620

gctgaggaag cgttcctttg ggaacccgtt tgagccccaa gcacggaggg aagagcgatc     1680

catgtctgct ccaggaaacc tactggtgta agtactggtg ggccagggac tgccgggcac     1740

tccctggagt tgggtgggga ggtctgaggc ccatcctccc actctcactg tcgttgggcc     1800

aaggccagag cctggggact tggccaggtc tcggtgttgg ccccatttgc atctctgtcc     1860

ccaaggttag tcggggctag aagggacctt ttgggcccag ctcttgcttc attcctgggg     1920

ccagcatccc tcacacacac acttccaggg atgaggagct cacgcagccc ctccatggga     1980

caggaagacc cttcttccat gcagcttgat gtcactctct cactgggtcc agcccctctg     2040

gggcttcaaa tctgtggccc cctcagccct tggcagcctg gcagaggttt gcagacaggc     2100

tgatgttggc ttcctgtagg aggctggcgg gctgtagagg aggggtgctg gcccctctgc     2160

ctggccctgg ggactgttgg ctgctctccc aagtggccca ggctgcctgc agccattgct     2220

ggggctctgt gcccagtcag cactttgtga gtgcttgttc agtgagtaag cagggacagg     2280

ctggccggtg gaccacggga gaggaacccg cattggccga gggctcccta tggtgagcca     2340

cgcctgtggg ttcaccacct cctaggaggg tccagaaaag cagctcccca agcctgtgcg     2400

cctcgtcctc agcagatcca ccttcttcac tataataaaa gccagtctgg gatgctaaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2520

aaaaaaaaaa aaaaa                                                      2535


<210>  58
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Ala Leu Gln Asn Gln Ala Gln Asn Ile Gln Leu Asp 
225                 230                 235                 240 


Ser Thr Asn Ile Ala Lys Pro His Ser Leu Leu Pro Ser Glu Gln Gln 
                245                 250                 255     


Asp Ser Gly Ser Thr Trp Ala Ala Arg Ser Val Phe Asp Leu Leu Arg 
            260                 265                 270         


Lys Gly Pro Val Met Glu Val Pro Cys Asp Lys Pro Phe Ser Glu Glu 
        275                 280                 285             


Gln Ala Arg Leu Tyr Leu Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu 
    290                 295                 300                 


His Cys Gln Lys Ile Val His Arg Asp Ile Lys Pro Ser Asn Leu Leu 
305                 310                 315                 320 


Leu Gly Asp Asp Gly His Val Lys Ile Ala Asp Phe Gly Val Ser Asn 
                325                 330                 335     


Gln Phe Glu Gly Asn Asp Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro 
            340                 345                 350         


Ala Phe Met Ala Pro Glu Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser 
        355                 360                 365             


Gly Lys Ala Leu Asp Val Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe 
    370                 375                 380                 


Val Tyr Gly Lys Cys Pro Phe Ile Asp Asp Phe Ile Leu Ala Leu His 
385                 390                 395                 400 


Arg Lys Ile Lys Asn Glu Pro Val Val Phe Pro Glu Glu Pro Glu Ile 
                405                 410                 415     


Ser Glu Glu Leu Lys Asp Leu Ile Leu Lys Met Leu Asp Lys Asn Pro 
            420                 425                 430         


Glu Thr Arg Ile Gly Val Pro Asp Ile Lys Leu His Pro Trp Val Thr 
        435                 440                 445             


Lys Asn Gly Glu Glu Pro Leu Pro Ser Glu Glu Glu His Cys Ser Val 
    450                 455                 460                 


Val Glu Val Thr Glu Glu Glu Val Lys Asn Ser Val Arg Leu Ile Pro 
465                 470                 475                 480 


Ser Trp Thr Thr Val Ile Leu Val Lys Ser Met Leu Arg Lys Arg Ser 
                485                 490                 495     


Phe Gly Asn Pro Phe Glu Pro Gln Ala Arg Arg Glu Glu Arg Ser Met 
            500                 505                 510         


Ser Ala Pro Gly Asn Leu Leu Val 
        515                 520 


<210>  59
<211>  1153
<212>  DNA
<213>  Homo sapiens

<400>  59
gaaaacacca aatcaaccat aggtccaaga acaattgtct ctggacggca gctatgcgac       60

tcaccgtgct gtgtgctgtg tgcctgctgc ctggcagcct ggccctgccg ctgcctcagg      120

aggcgggagg catgagtgag ctacagtggg aacaggctca ggactatctc aagagatttt      180

atctctatga ctcagaaaca aaaaatgcca acagtttaga agccaaactc aaggagatgc      240

aaaaattctt tggcctacct ataactggaa tgttaaactc ccgcgtcata gaaataatgc      300

agaagcccag atgtggagtg ccagatgttg cagaatactc actatttcca aatagcccaa      360

aatggacttc caaagtggtc acctacagga tcgtatcata tactcgagac ttaccgcata      420

ttacagtgga tcgattagtg tcaaaggctt taaacatgtg gggcaaagag atccccctgc      480

atttcaggaa agttgtatgg ggaactgctg acatcatgat tggctttgcg cgaggagctc      540

atggggactc ctacccattt gatgggccag gaaacacgct ggctcatgcc tttgcgcctg      600

ggacaggtct cggaggagat gctcacttcg atgaggatga acgctggacg gatggtagca      660

gtctagggat taacttcctg tatgctgcaa ctcatgaact tggccattct ttgggtatgg      720

gacattcctc tgatcctaat gcagtgatgt atccaaccta tggaaatgga gatccccaaa      780

attttaaact ttcccaggat gatattaaag gcattcagaa actatatgga aagagaagta      840

attcaagaaa gaaatagaaa cttcaggcag aacatccatt cattcattca ttggattgta      900

tatcattgtt gcacaatcag aattgataag cactgttcct ccactccatt tagcaattat      960

gtcacccttt tttattgcag ttggtttttg aatgtctttc actcctttta aggataaact     1020

cctttatggt gtgactgtgt cttattcatc tatacttgca gtgggtagat gtcaataaat     1080

gttacataca caaataaata aaatgtttat tccatggtaa atttaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaa                                                        1153


<210>  60
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 
            20                  25                  30          


Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 
        35                  40                  45              


Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 
                85                  90                  95      


Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 
            100                 105                 110         


Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 
        115                 120                 125             


Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 
    130                 135                 140                 


Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 
        195                 200                 205             


Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 


Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            260                 265         


<210>  61
<211>  451
<212>  DNA
<213>  Homo sapiens

<400>  61
gggttgcgga gggtgggcct gggaggggtg gtggccattt tttgtctaac cctaactgag       60

aagggcgtag gcgccgtgct tttgctcccc gcgcgctgtt tttctcgctg actttcagcg      120

ggcggaaaag cctcggcctg ccgccttcca ccgttcattc tagagcaaac aaaaaatgtc      180

agctgctggc ccgttcgccc ctcccgggga cctgcggcgg gtcgcctgcc cagcccccga      240

accccgcctg gaggccgcgg tcggcccggg gcttctccgg aggcacccac tgccaccgcg      300

aagagttggg ctctgtcagc cgcgggtctc tcgggggcga gggcgaggtt caggcctttc      360

aggccgcagg aagaggaacg gagcgagtcc ccgcgcgcgg cgcgattccc tgagctgtgg      420

gacgtgcacc caggactcgg ctcacacatg c                                     451


