                         SEQUENCE LISTING

<110>  The Rockefeller University
 
<120>  ANTI-MERTK AGONISTIC ANTIBODY-DRUG CONJUGATES AND USES THEREOF

<130>  070413.20336/13256-007-888

<140>  New Application
<141>  2018-06-26

<150>  62/525,993
<151>  2017-06-28

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR1 according to Kabat

<400>  1

Asn Tyr Gly Met Asn 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR1 according to Chothia

<400>  2

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR1 according to AbM

<400>  3

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR1 according to Contact

<400>  4

Thr Asn Tyr Gly Met Asn 
1               5       


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR1 according to IMGT

<400>  5

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR2 according to Kabat

<400>  6

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR2 according to Chothia

<400>  7

Thr Tyr Thr Gly 
1               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR2 according to AbM

<400>  8

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR2 according to Contact

<400>  9

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10              


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR2 according to IMGT

<400>  10

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR3 according to Kabat

<400>  11

Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val 
1               5                   10      


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR3 according to Chothia

<400>  12

Ser Thr Val Val Ser Arg Tyr Phe Asp 
1               5                   


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR3 according to Contact

<400>  13

Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp 
1               5                   10          


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH CDR3 according to IMGT

<400>  14

Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val 
1               5                   10              


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR1 according to Kabat

<400>  15

Lys Ala Ser Gln Asp Val Gly Asp Ala Val Thr 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR1 according to Chothia

<400>  16

Ser Gln Asp Val Gly Asp Ala 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR1 according to Contact

<400>  17

Gly Asp Ala Val Thr Trp Cys 
1               5           


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR1 according to IMPT

<400>  18

Gln Asp Val Gly Asp Ala 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR2 according to Kabat

<400>  19

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR2 according to Chothia

<400>  20

Trp Ala Ser 
1           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR2 according to Contact

<400>  21

Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR3 according to Kabat

<400>  22

Gln Gln Tyr Arg Ser Tyr Pro Leu Thr 
1               5                   


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR3 according to Chothia

<400>  23

Tyr Arg Ser Tyr Pro Leu 
1               5       


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL CDR3 according to Contact

<400>  24

Gln Gln Tyr Arg Ser Tyr Pro Leu 
1               5               


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR1 according to Kabat

<400>  25

Asp Tyr Ser Met His 
1               5   


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR1 according to Chothia

<400>  26

Asn Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR1 according to AbM

<400>  27

Asn Tyr Thr Phe Thr Asp Tyr Ser Met His 
1               5                   10  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR1 according to Contact

<400>  28

Thr Asp Tyr Ser Met His 
1               5       


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR1 according to IMGT

<400>  29

Asn Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR2 according to Kabat

<400>  30

Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR2 according to Chothia

<400>  31

Thr Asp Thr Gly 
1               


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR2 according to AbM

<400>  32

Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr 
1               5                   10  


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR2 according to Contact

<400>  33

Trp Val Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr 
1               5                   10              


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR2 according to IMGT

<400>  34

Ile Asn Thr Asp Thr Gly Glu Pro 
1               5               


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR3 according to Kabat

<400>  35

Trp Phe Gly Ala Met Asp Tyr 
1               5           


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR3 according to Chothia

<400>  36

Phe Gly Ala Met Asp 
1               5   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR3 according to Contact

<400>  37

Ala Arg Trp Phe Gly Ala Met Asp 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH CDR3 according to IMGT

<400>  38

Ala Arg Trp Phe Gly Ala Met Asp Tyr 
1               5                   


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR1 according to Kabat

<400>  39

Lys Ala Ser Gln Asp Val Thr Asn Val Val Ala 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR1 according to Chothia

<400>  40

Ser Gln Asp Val Thr Asn Val 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR1 according to Contact

<400>  41

Thr Asn Val Val Ala Trp Tyr 
1               5           


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR1 according to IMGT

<400>  42

Gln Asp Val Thr Asn Val 
1               5       


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR2 according to Kabat

<400>  43

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  44
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR2 according to Chothia

<400>  44

Ser Ala Ser 
1           


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR2 according to Contact

<400>  45

Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
1               5                   10  


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR3 according to Kabat

<400>  46

Gln Gln Tyr Tyr Arg Thr Pro Arg Thr 
1               5                   


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR3 according to Chothia

<400>  47

Tyr Tyr Arg Thr Pro Arg 
1               5       


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL CDR3 according to Contact

<400>  48

Gln Gln Tyr Tyr Arg Thr Pro Arg 
1               5               


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH Variable Region

<400>  49

Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Ser Thr Val Val Ser Arg Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL Variable Region

<400>  50

Asp Ile Val Leu Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Thr Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  51
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH Variable Region

<400>  51

Glu Val Gln Leu Glu Glu Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Asn Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Phe Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  52
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL Variable Region

<400>  52

Asp Ile Val Ile Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Asn Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Arg Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  53
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VH Variable Region

<400>  53
caggttaagc tggaggagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgtcttc tctttggaaa cctctgccag cactgcctac      240

ttgcagatca acaacctcaa aaatgaggac atggccacat atttctgtgc aagaaaaagt      300

acggtagtaa gtaggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  54
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody M6 VL Variable Region

<400>  54
gggatattgt gctgacacag actcacaaat tcatgtccac atcagtagga gacagggtca       60

gcatcacctg caaggccagt caggatgtgg gtgatgctgt aacctggtgt caacagaaac      120

caggtcaacc tcctaaacta ctgatttact gggcatccac ccggcacact ggagtccctg      180

atcgcttcac aggcagtggg tctgggacag atttcactct caccattaac aatgtgcagt      240

ctgaagactt ggcagattat ttctgtcagc aatatcgcag ctatcctctc acgttcggtg      300

ctgggaccaa gctggagctg                                                  320


<210>  55
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VH Variable Region

<400>  55
gaggtccagc tggaggagtc tggacctgac ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctaatta taccttcaca gactattcaa tgcactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg ggtgggctgg ataaacactg acactggtga gccaacatat      180

gcagatgact tcaagggacg ctttgccttc tctttggaaa cctctgccag cactgcctat      240

ttacagatca acaacctcaa aaatgaggac acggctacat atttctgtgc tagatggttt      300

ggtgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagc caaaacgaca      360

cccccatctg tctattcc                                                    378


<210>  56
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody M19 VL Variable Region

<400>  56
gggatattgt gatcacacag tctcacaaat tcatgtccac atcagtagga gacagggtca       60

gcatcacctg caaggccagt caggatgtga ctaatgttgt agcctggtat caacagaaac      120

caggacaatc tcctaaacta ctgatttatt cggcatccta ccggtacact ggagtccctg      180

atcgcttcac tggcagtgga tctgggacgg atttcacttt caccatcagc agtgtgcagg      240

ctgaagacct ggcagtttat tactgtcagc aatattatcg tactcctcgg acgttcggtg      300

gaggcaccaa gctggaaatc aaacgg                                           326


<210>  57
<211>  999
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-Length Human MERTK (Swuss-Prot ID Q12866.2)

<400>  57

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  58
<211>  474
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Extracellular Doman of MERTK Used for Immunization

<400>  58

Arg Glu Glu Ala Lys Pro Tyr Pro Leu Phe Pro Gly Pro Phe Pro Gly 
1               5                   10                  15      


Ser Leu Gln Thr Asp His Thr Pro Leu Leu Ser Leu Pro His Ala Ser 
            20                  25                  30          


Gly Tyr Gln Pro Ala Leu Met Phe Ser Pro Thr Gln Pro Gly Arg Pro 
        35                  40                  45              


His Thr Gly Asn Val Ala Ile Pro Gln Val Thr Ser Val Glu Ser Lys 
    50                  55                  60                  


Pro Leu Pro Pro Leu Ala Phe Lys His Thr Val Gly His Ile Ile Leu 
65                  70                  75                  80  


Ser Glu His Lys Gly Val Lys Phe Asn Cys Ser Ile Ser Val Pro Asn 
                85                  90                  95      


Ile Tyr Gln Asp Thr Thr Ile Ser Trp Trp Lys Asp Gly Lys Glu Leu 
            100                 105                 110         


Leu Gly Ala His His Ala Ile Thr Gln Phe Tyr Pro Asp Asp Glu Val 
        115                 120                 125             


Thr Ala Ile Ile Ala Ser Phe Ser Ile Thr Ser Val Gln Arg Ser Asp 
    130                 135                 140                 


Asn Gly Ser Tyr Ile Cys Lys Met Lys Ile Asn Asn Glu Glu Ile Val 
145                 150                 155                 160 


Ser Asp Pro Ile Tyr Ile Glu Val Gln Gly Leu Pro His Phe Thr Lys 
                165                 170                 175     


Gln Pro Glu Ser Met Asn Val Thr Arg Asn Thr Ala Phe Asn Leu Thr 
            180                 185                 190         


Cys Gln Ala Val Gly Pro Pro Glu Pro Val Asn Ile Phe Trp Val Gln 
        195                 200                 205             


Asn Ser Ser Arg Val Asn Glu Gln Pro Glu Lys Ser Pro Ser Val Leu 
    210                 215                 220                 


Thr Val Pro Gly Leu Thr Glu Met Ala Val Phe Ser Cys Glu Ala His 
225                 230                 235                 240 


Asn Asp Lys Gly Leu Thr Val Ser Lys Gly Val Gln Ile Asn Ile Lys 
                245                 250                 255     


Ala Ile Pro Ser Pro Pro Thr Glu Val Ser Ile Arg Asn Ser Thr Ala 
            260                 265                 270         


His Ser Ile Leu Ile Ser Trp Val Pro Gly Phe Asp Gly Tyr Ser Pro 
        275                 280                 285             


Phe Arg Asn Cys Ser Ile Gln Val Lys Glu Ala Asp Pro Leu Ser Asn 
    290                 295                 300                 


Gly Ser Val Met Ile Phe Asn Thr Ser Ala Leu Pro His Leu Tyr Gln 
305                 310                 315                 320 


Ile Lys Gln Leu Gln Ala Leu Ala Asn Tyr Ser Ile Gly Val Ser Cys 
                325                 330                 335     


Met Asn Glu Ile Gly Trp Ser Ala Val Ser Pro Trp Ile Leu Ala Ser 
            340                 345                 350         


Thr Thr Glu Gly Ala Pro Ser Val Ala Pro Leu Asn Val Thr Val Phe 
        355                 360                 365             


Leu Asn Glu Ser Ser Asp Asn Val Asp Ile Arg Trp Met Lys Pro Pro 
    370                 375                 380                 


Thr Lys Gln Gln Asp Gly Glu Leu Val Gly Tyr Arg Ile Ser His Val 
385                 390                 395                 400 


Trp Gln Ser Ala Gly Ile Ser Lys Glu Leu Leu Glu Glu Val Gly Gln 
                405                 410                 415     


Asn Gly Ser Arg Ala Arg Ile Ser Val Gln Val His Asn Ala Thr Cys 
            420                 425                 430         


Thr Val Arg Ile Ala Ala Val Thr Arg Gly Gly Val Gly Pro Phe Ser 
        435                 440                 445             


Asp Pro Val Lys Ile Phe Ile Pro Ala His Gly Trp Val Asp Tyr Ala 
    450                 455                 460                 


Pro Ser Ser Thr Pro Ala Pro Gly Asn Ala 
465                 470                 