                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
 
<120>  METHOD FOR REMOVING AND/OR DETECTING NUCLEIC ACIDS HAVING 
       MISMATCHED NUCLEOTIDES

<130>  NEB-401-PCT

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Methanobrevibacter

<400>  1

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Cys Glu Asp Ala Tyr Gly 
1               5                   10                  15      


Leu Ile Glu Glu Ala Leu Arg Lys Arg Ala Thr Ile Thr Ile Tyr Ala 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Gly Tyr Ile Gln Asp Asn Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Val Glu Ile Arg Lys Val Gln Tyr 
            100                 105                 110         


Ile Thr Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Cys Asp Asn Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asp Asp Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Leu Val Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Glu Asp Ala Lys Glu Leu Ile Glu Lys Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ala Val Asn Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  2
<211>  260
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  2

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Cys Glu Asp Ala Tyr Gly 
1               5                   10                  15      


Leu Ile Glu Glu Ala Leu Arg Lys Arg Ala Thr Ile Thr Ile Tyr Ala 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Gly Tyr Ile Gln Asp Asn Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Val Glu Ile Arg Lys Val Gln Tyr 
            100                 105                 110         


Ile Thr Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Cys Asp Asn Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asp Gly Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Leu Val Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Glu Asp Ala Lys Glu Leu Ile Glu Lys Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ala Val Asn Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  3
<211>  260
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  3

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Cys Glu Asp Ala Tyr Gly 
1               5                   10                  15      


Leu Val Glu Glu Ala Leu Arg Lys Lys Ala Thr Ile Thr Ile Tyr Ala 
            20                  25                  30          


Cys Cys Lys Val Thr Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Gly Tyr Ile Gln Asp Asp Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Ile Val Glu Ile Arg Lys Val Gln Tyr 
            100                 105                 110         


Ile Thr Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Arg Asp Asn Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asp Asp Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Arg Val Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Asn Asp Ala Glu Glu Leu Leu Glu Lys Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ala Val Glu Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  4
<211>  260
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  4

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Cys Glu Asp Ala Tyr Gly 
1               5                   10                  15      


Leu Val Glu Glu Ala Leu Arg Lys Lys Ala Thr Ile Thr Ile Tyr Ala 
            20                  25                  30          


Cys Cys Lys Val Thr Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Gly Tyr Ile Gln Asp Asp Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Ile Val Glu Ile Arg Lys Val Gln Tyr 
            100                 105                 110         


Ile Thr Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Lys Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Arg Asp Asn Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asp Asp Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Arg Val Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Asn Asp Ala Glu Glu Leu Leu Glu Lys Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ala Val Glu Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  5
<211>  260
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  5

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Cys Glu Asp Ala Tyr Gly 
1               5                   10                  15      


Leu Val Glu Glu Ala Leu Arg Lys Lys Ala Thr Ile Thr Ile Tyr Ala 
            20                  25                  30          


Cys Cys Lys Val Thr Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Gly Tyr Ile Gln Asp Asp Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Ile Val Glu Ile Arg Lys Val Gln Tyr 
            100                 105                 110         


Ile Thr Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Arg Asn Asn Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asp Asp Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Arg Val Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Asn Asp Ala Glu Glu Leu Leu Glu Lys Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ala Val Glu Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  6
<211>  260
<212>  PRT
<213>  Methanobrevibacter oralis

<400>  6

Met Lys Tyr Arg Ile Leu Glu Arg Pro Ser Cys Glu Glu Gly Tyr Asp 
1               5                   10                  15      


Leu Val Glu Glu Ala Leu Arg Lys Lys Ala Thr Ile Ile Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Ser Phe Ile Arg Asn Asp Lys Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Val Pro Lys Glu Leu Leu Ser Val Glu Ile Arg Lys Ile Gln Phe 
            100                 105                 110         


Ile Asn Tyr Ala Asn Val Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Asp Lys Pro His Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Asp Asp Asn Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Ser Asp Phe Glu Asn Thr Glu Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Lys Ala Ser Lys Lys Arg Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Glu Asp Ala Lys Glu Met Ile Glu Asp Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Ile Glu Pro Pro Lys Glu Leu Arg Arg Asp Lys Lys Thr Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  7
<211>  260
<212>  PRT
<213>  Methanobrevibacter gottschalkii

<400>  7

Met Lys Tyr Lys Ile Leu Glu Lys Pro Ser Cys Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Leu Val Gln Glu Ala Leu Arg Lys Lys Ala Thr Ile Leu Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Ser Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Met Ile Lys Pro Asp Gly Thr Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Ser Tyr Ile Lys Asn Asp Asn Leu Phe Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Val Glu Ile Arg Lys Ile Gln Phe 
            100                 105                 110         


Ile Asn Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Arg Asp Asn Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Ile Thr Ala Val Lys Gln Leu Arg 
            180                 185                 190         


Arg Tyr Leu Gln Asp Leu Glu Asn Thr Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Glu Ser Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Met Asp Asp Ala Leu Glu Leu Leu Glu Asn Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Ile Glu Pro Pro Arg Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  8
<211>  260
<212>  PRT
<213>  Methanobrevibacter

<400>  8

Met Lys Tyr Lys Ile Leu Glu Lys Pro Ser Cys Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Leu Val Gln Glu Ala Leu Arg Lys Lys Thr Thr Ile Leu Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Ser Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Met Ile Lys Pro Asp Gly Thr Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Ser Tyr Ile Lys Asn Asp Asn Leu Phe Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Val Glu Ile Arg Lys Ile Gln Phe 
            100                 105                 110         


Ile Asn Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Lys Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ser Asp Asn Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Ile Thr Ala Val Lys Gln Leu Arg 
            180                 185                 190         


Arg Tyr Leu Gln Asp Leu Glu Asn Thr Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Glu Ser Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Met Asp Asp Ala Leu Glu Leu Leu Glu Asn Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Ile Glu Pro Pro Arg Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  9
<211>  260
<212>  PRT
<213>  Methanobrevibacter millerae

<400>  9

Met Lys Tyr Lys Ile Leu Glu Lys Pro Asp Cys Glu Lys Ala Tyr Glu 
1               5                   10                  15      


Leu Val Glu Glu Ala Met Arg Lys Arg Ala Thr Ile Thr Leu Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Glu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Asp Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Ser Tyr Leu Ser Gly Glu Arg Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Val Glu Val Arg Gln Ile Gln Phe 
            100                 105                 110         


Ile Ser Tyr Ala Asn Met Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Ser Asp Met Ile Met Glu Arg Pro His Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Lys Thr Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Asn Asp Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Gln Asp Leu Glu Asn Thr Glu Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Lys Ala Gln Lys Lys Lys Ile Arg Gly Ile Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Met Glu Asp Ala Arg Glu Met Ile Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Val Glu Pro Pro Arg Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  10
<211>  260
<212>  PRT
<213>  Methanobrevibacter

<400>  10

Met Lys Tyr Lys Ile Leu Glu Lys Pro Asn Cys Glu Asp Ala Tyr Glu 
1               5                   10                  15      


Leu Val Gln Asp Ala Leu Arg Lys Lys Ala Thr Ile Ile Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Met Ile Lys Pro Asp Gly Ala Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Ser Tyr Ile Lys Asn Glu Asn Leu Phe Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Leu Leu Thr Ala Glu Ile Arg Gln Ile Gln Phe 
            100                 105                 110         


Ile Ser Tyr Ala Asn Ile Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Ser Asp Met Ile Met Glu Lys Pro His Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Thr Thr Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ser Asp Asn Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ala Ala Val Lys Gln Leu Arg 
            180                 185                 190         


Arg Tyr Leu Gln Asp Leu Glu Asn Thr Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Lys Ala Gln Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Met Asp Asp Ala Leu Glu Leu Ile Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Ile Glu Pro Pro Arg Glu Leu Lys Arg Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ala Phe 
            260 


<210>  11
<211>  254
<212>  PRT
<213>  Methanobrevibacter oralis

<400>  11

Met Lys Tyr Arg Ile Leu Glu Arg Pro Ser Cys Glu Glu Gly Tyr Asp 
1               5                   10                  15      


Leu Val Glu Glu Ala Leu Arg Lys Lys Ala Thr Ile Ile Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asn Trp 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Ser Phe Ile Arg Asn Asp Lys Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Val Pro Lys Glu Leu Leu Ser Val Glu Ile Arg Lys Ile Gln Phe 
            100                 105                 110         


Ile Asn Tyr Ala Asn Val Glu Asp Phe Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Asp Lys Pro His Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Thr Pro Thr Ala Arg Glu Tyr Ser Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Asp Asp Asn Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Ser Asp Phe Glu Asn Thr Glu Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Cys Lys Ala Ser Lys Lys Arg Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Leu Gly Glu Asp Ala Lys Glu Met Ile Glu Asp Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Ile Glu Pro Pro Lys Glu Leu Arg Arg Asp Lys Lys 
                245                 250                 


<210>  12
<211>  260
<212>  PRT
<213>  Methanobrevibacter cuticularis

<400>  12

Met Lys Tyr Lys Leu Leu Glu Asn Pro Asn Ile Glu Glu Met Tyr Asp 
1               5                   10                  15      


Leu Ile Glu Glu Gly Leu Arg Lys Lys Ala Met Ile Asn Val Phe Cys 
            20                  25                  30          


Cys Cys Lys Val Ile Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asp Phe 
        35                  40                  45              


Gly Glu Arg Met Ile Leu Leu Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Glu Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Arg Thr Phe Ile Lys Asp Asn Thr Leu Phe Leu Glu Ser His Arg 
                85                  90                  95      


Arg Ser Pro Lys Glu Arg Leu Glu Val Glu Ile Lys Lys Thr His Phe 
            100                 105                 110         


Val Asn Tyr Val Leu Val Glu Asp Tyr Gln Glu Leu Glu Ile Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Lys His Pro His Met Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Asp Arg Glu Tyr Ser Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Lys Glu Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Cys Arg Lys Ala Gly Ile Asn Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Lys Glu Glu Glu Asn Ser Asn Leu Glu Asn 
        195                 200                 205             


Thr Gly Asn Glu Lys Lys Lys Val Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Gly Glu Asp Ala Arg Glu Leu Leu Glu Glu Glu Asn Ile Glu Phe 
225                 230                 235                 240 


Lys Ser Ile Asp Pro Pro Lys Glu Leu Lys Asn Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ile Phe 
            260 


<210>  13
<211>  260
<212>  PRT
<213>  Methanobrevibacter curvatus

<400>  13

Met Lys Phe Lys Gly Lys Glu Asp Pro Asn Ile Asp Glu Ser Phe Asp 
1               5                   10                  15      


Leu Ile Asp Glu Gly Leu Arg Lys Lys Ala Thr Ile Val Ile Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Ile Tyr Glu Gly Arg Ala Ile Ser Gln Leu Asp Phe 
        35                  40                  45              


Gly Glu Arg Ile Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Asp Lys Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Ser Arg Val Leu Ile Arg Asn Glu Lys Leu Phe Leu Glu Ser Phe Arg 
                85                  90                  95      


Arg Thr Pro Arg Glu His Leu Glu Val Glu Ile Arg Lys Ile His Phe 
            100                 105                 110         


Leu Asn Tyr Ala Leu Ile Glu Asp Tyr Gln Glu Leu Glu Ile Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Leu Gly Asp Leu Ile Ile Asp Lys Pro His Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Asn Arg Glu Tyr Ser Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Asn Asp Lys Glu Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ile Gly Val Asn Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Ser Asp Phe Glu Asp Glu Lys Asn Ser Tyr Leu Lys Asp 
        195                 200                 205             


Leu Gly Val Glu Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Lys 
    210                 215                 220                 


Ile Asp Glu Asp Ala Lys Glu Met Ile Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Leu Glu Pro Pro Lys Glu Leu Lys Arg Asp Lys Leu Val Thr 
                245                 250                 255     


Leu Asp Ser Phe 
            260 


<210>  14
<211>  260
<212>  PRT
<213>  Methanobrevibacter olleyae

<400>  14

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Tyr Glu Glu Thr Tyr Asp 
1               5                   10                  15      


Leu Ile Glu Glu Gly Leu Lys Lys Lys Ala Thr Ile Leu Leu Phe Ala 
            20                  25                  30          


Cys Cys Arg Val Ser Tyr Glu Gly Arg Ser Leu Ser Glu Leu Asp Tyr 
        35                  40                  45              


Gly Glu Arg Ile Ile Met Met Lys Pro Asp Gly Cys Phe Leu Ile His 
    50                  55                  60                  


Gln Asp Asn Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Pro Arg Ala Tyr Ile Lys Asp Glu Ile Leu Phe Leu Glu Ser His Arg 
                85                  90                  95      


Arg Ser Pro Pro Glu Arg Ile Glu Val Glu Ile Lys Lys Val His Tyr 
            100                 105                 110         


Ala Asn Tyr Asn Leu Ile Glu Asp Tyr Glu Glu Leu Glu Arg Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Trp Asp Lys Pro His Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Arg Pro Thr Val Arg Glu Tyr Ala Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ser Lys Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Ile Thr Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asn Lys Glu Asn Ser Glu Ile Lys Ala 
        195                 200                 205             


Lys Asn Gly Gln Lys Gln Lys Ile Arg Gly Leu Leu Val Ala Pro Ser 
    210                 215                 220                 


Ile Gly Asp Asp Ala Leu Glu Leu Leu Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Val Ser Val Glu Pro Pro Arg Glu Leu Lys Lys Asp Lys Arg Val Thr 
                245                 250                 255     


Leu Asp Ser Phe 
            260 


<210>  15
<211>  259
<212>  PRT
<213>  Methanobrevibacter ruminantium

<400>  15

Met Lys Tyr Lys Ile Leu Glu Asn Pro Asn Tyr Lys Glu Ala Tyr Glu 
1               5                   10                  15      


Leu Ile Glu Glu Gly Leu Val Lys Lys Ala Thr Met Leu Leu Phe Ala 
            20                  25                  30          


Cys Cys Lys Val Ser Tyr Glu Gly Arg Ala Leu Ser Glu Leu Asp Tyr 
        35                  40                  45              


Gly Glu Arg Ile Ile Met Ile Lys Pro Asp Gly Cys Phe Leu Ile His 
    50                  55                  60                  


Gln Asp Asn Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Lys Ala Leu Ile Lys Asp Glu Thr Leu Tyr Leu Glu Ser His Arg 
                85                  90                  95      


Arg Lys Pro Pro Glu Leu Leu Glu Val Glu Val Lys Lys Ile His Tyr 
            100                 105                 110         


Ala Arg Tyr Asn Leu Ile Glu Asp Tyr Glu Glu Leu Glu Arg Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Trp Asp Asn Pro His Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Arg Pro Thr Val Arg Glu Tyr Ala Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ala Asp Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ala Arg Lys Ala Gly Ile Thr Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Thr Asp Phe Glu Asn Arg Glu Asn Lys Glu Ile Arg His 
        195                 200                 205             


Glu Glu Glu Lys Gln Lys Val Arg Gly Leu Leu Val Ala Pro Ser Ile 
    210                 215                 220                 


Gly Asp Asp Ala Leu Glu Leu Leu Glu Glu Glu Gly Ile Glu Phe Val 
225                 230                 235                 240 


Ser Val Glu Pro Pro Arg Glu Leu Lys Lys Asp Lys Lys Val Thr Leu 
                245                 250                 255     


Asp Ala Phe 
            


<210>  16
<211>  259
<212>  PRT
<213>  Methanobrevibacter

<400>  16

Met Asn Tyr Lys Thr Ile Glu Glu Pro Asn Thr Glu Glu Thr Tyr Asp 
1               5                   10                  15      


Leu Ile Glu Ala Gly Leu Arg Lys Lys Ala Met Ile Thr Leu Phe Thr 
            20                  25                  30          


Tyr Cys Lys Val Glu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Gly Tyr 
        35                  40                  45              


Gly Glu Arg Met Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Asp Arg Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Arg Val Phe Ile Arg Asp Gly Lys Val Ile Ile Glu Ser Asn Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Arg Leu Glu Val Leu Ile Glu Lys Thr Phe Ile 
            100                 105                 110         


Gly Thr Tyr Ala Val Val Glu Asp Tyr Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Glu Asn Pro His Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Thr Asp Arg Glu Tyr Asn Val Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ser Asp Gly Asn Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ile Gly Ile Ser Ala Val Lys Gln Ile Lys 
            180                 185                 190         


Arg Tyr Ile Asp Asp Leu Thr Asn Thr Glu Asn Arg Ser Leu Arg Leu 
        195                 200                 205             


Gly Val Glu Lys Lys Lys Ile Arg Gly Leu Leu Val Gly Pro Lys Ile 
    210                 215                 220                 


Asp Glu Asp Ala Lys Glu Met Ile Glu Glu Glu Gly Ile Glu Phe Val 
225                 230                 235                 240 


Glu Cys Glu Pro Pro Lys Glu Leu Lys Arg Asp Lys Lys Thr Thr Leu 
                245                 250                 255     


Asp Ser Phe 
            


<210>  17
<211>  260
<212>  PRT
<213>  Methanobrevibacter arboriphilus

<400>  17

Met Lys Tyr Lys Leu Leu Glu Asn Pro Asp Ile Glu Glu Ala Tyr Asp 
1               5                   10                  15      


Leu Ile Asp Ser Gly Ile Arg Lys Lys Ala Val Ile Asn Ile Phe Ala 
            20                  25                  30          


Tyr Cys Lys Val Leu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asp Trp 
        35                  40                  45              


Gly Glu Arg Phe Ile Met Leu Lys Pro Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Glu Arg Lys Ile Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


His Arg Ala Leu Ile Lys Glu Asn Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Lys Leu Glu Val Glu Ile Glu Lys Val His Phe 
            100                 105                 110         


Ala Ser Phe Ala Leu Ala Glu Asp Tyr Gln Glu Leu Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Ile Lys His Pro Asn Met Ile 
    130                 135                 140                 


Glu Gln Gly Phe Thr Pro Thr Ala Arg Glu Tyr Asn Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ile Glu Gly Asn Ile Val Val Val 
                165                 170                 175     


Glu Leu Lys Cys Arg Lys Ala Gly Thr Asn Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Lys Asp Phe Glu Glu Asn Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Ile Lys Ser Lys Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Asp 
    210                 215                 220                 


Ile Asn Glu Asp Ala Lys Glu Leu Leu Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Lys Ala Val Asp Pro Pro Lys Glu Leu Lys Ser Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ile Phe 
            260 


<210>  18
<211>  261
<212>  PRT
<213>  Methanobrevibacter arboriphilus

<400>  18

Met Lys Tyr Lys Leu Leu Glu Asn Pro Asp Ile Glu Glu Thr Tyr Asp 
1               5                   10                  15      


Leu Ile Asp Ser Gly Ile Arg Lys Lys Ala Val Ile Asn Ile Phe Ala 
            20                  25                  30          


Tyr Cys Lys Val Leu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asp Trp 
        35                  40                  45              


Gly Gly Glu Arg Phe Ile Met Leu Lys Pro Asp Gly Ser Phe Leu Val 
    50                  55                  60                  


His Gln Glu Arg Lys Ile Asp Pro Val Asn Trp Gln Pro Pro Lys Ser 
65                  70                  75                  80  


Arg His Arg Ala Leu Ile Lys Glu Asn Asn Leu Ile Leu Glu Ser His 
                85                  90                  95      


Arg Arg Thr Pro Lys Glu Lys Leu Glu Val Glu Ile Glu Lys Val His 
            100                 105                 110         


Phe Ala Ser Phe Ala Leu Ala Glu Asp Tyr Gln Glu Leu Glu Leu Ala 
        115                 120                 125             


Gly Tyr Glu Lys Asp Met Gly Asp Met Ile Ile Lys His Pro Asn Met 
    130                 135                 140                 


Ile Glu Gln Gly Phe Thr Pro Thr Ala Arg Glu Tyr Asn Thr Glu His 
145                 150                 155                 160 


Gly Phe Ile Asp Ile Leu Gly Lys Asp Ile Glu Gly Asn Ile Val Val 
                165                 170                 175     


Val Glu Leu Lys Cys Arg Lys Ala Gly Thr Asn Ala Val Lys Gln Ile 
            180                 185                 190         


Arg Arg Tyr Leu Lys Asp Phe Glu Glu Asn Asp Asn Asp Tyr Leu Lys 
        195                 200                 205             


Glu Ile Lys Ser Lys Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro 
    210                 215                 220                 


Asp Ile Asn Glu Asp Ala Lys Glu Leu Leu Glu Glu Glu Gly Ile Glu 
225                 230                 235                 240 


Phe Lys Ala Val Asp Pro Pro Lys Glu Leu Lys Ser Asp Lys Lys Val 
                245                 250                 255     


Thr Leu Asp Ile Phe 
            260     


<210>  19
<211>  260
<212>  PRT
<213>  Methanobrevibacter arboriphilus

<400>  19

Met Lys Tyr Lys Leu Leu Glu Asn Pro Asp Ile Glu Glu Thr Tyr Asp 
1               5                   10                  15      


Leu Ile Asp Ser Gly Ile Arg Lys Lys Ala Val Ile Asn Ile Phe Ala 
            20                  25                  30          


Tyr Cys Lys Val Leu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asp Trp 
        35                  40                  45              


Gly Glu Arg Phe Ile Met Leu Lys Pro Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Glu Arg Lys Ile Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


His Arg Ala Leu Ile Lys Glu Asn Asn Leu Ile Leu Glu Ser His Arg 
                85                  90                  95      


Arg Thr Pro Lys Glu Lys Leu Glu Val Glu Ile Glu Lys Val His Phe 
            100                 105                 110         


Ala Ser Phe Ala Leu Ala Glu Asp Tyr Gln Glu Leu Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Ile Lys His Pro Asn Met Ile 
    130                 135                 140                 


Glu Gln Gly Phe Thr Pro Thr Ala Arg Glu Tyr Asn Thr Glu His Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Ile Glu Gly Asn Ile Val Val Val 
                165                 170                 175     


Glu Leu Lys Cys Arg Lys Ala Gly Ile Asn Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Leu Lys Asp Phe Glu Glu Asn Asp Asn Asp Tyr Leu Lys Glu 
        195                 200                 205             


Val Lys Ser Lys Lys Lys Lys Ile Arg Gly Leu Leu Val Ala Pro Asp 
    210                 215                 220                 


Ile Asn Glu Asp Ala Lys Glu Leu Leu Glu Glu Glu Gly Ile Glu Phe 
225                 230                 235                 240 


Lys Ala Val Asp Pro Pro Lys Glu Leu Arg Ser Asp Lys Lys Val Thr 
                245                 250                 255     


Leu Asp Ile Phe 
            260 


<210>  20
<211>  259
<212>  PRT
<213>  Methanobrevibacter wolinii

<400>  20

Met Asn Tyr Lys Asn Ile Glu Lys Pro Asn Ile Asn Glu Ser Tyr Asn 
1               5                   10                  15      


Phe Ile Glu Glu Gly Leu Arg Lys Arg Ala Thr Ile Ser Leu Tyr Thr 
            20                  25                  30          


Tyr Cys Lys Val Glu Tyr Glu Gly Arg Ala Leu Ser Gln Leu Asn Tyr 
        35                  40                  45              


Gly Glu Arg Leu Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Asn Lys Lys Val Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Thr Lys Val Tyr Ile Lys Asn Asn Lys Leu Phe Leu Glu Ser Asn Arg 
                85                  90                  95      


Lys Thr Pro Arg Glu Arg Leu Glu Val Glu Ile Asn Asn Ile Glu Thr 
            100                 105                 110         


Gly Thr Tyr Ala Ile Leu Glu Asp Tyr Glu Glu Leu Glu Gln Ala Gly 
        115                 120                 125             


Tyr Glu Lys Asp Met Gly Asp Met Ile Met Lys Asn Pro His Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Ser Ser Arg Glu Tyr Ser Val Asn Ser Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ile Gly Val Ser Ala Val Lys Gln Ile Arg 
            180                 185                 190         


Arg Tyr Val Glu Asp Leu Lys Asn Thr Glu Asn Lys Glu Phe Glu Thr 
        195                 200                 205             


Asp Asn Asn Lys Lys Arg Ile Arg Gly Ile Leu Val Ala Pro Lys Ile 
    210                 215                 220                 


Asp Asn Asp Ala Lys Glu Met Ile Glu Glu Glu Asn Phe Glu Phe Val 
225                 230                 235                 240 


Ala Cys Glu Pro Pro Lys Glu Leu Lys Lys Asp Lys Lys Val Thr Leu 
                245                 250                 255     


Asp Leu Phe 
            


<210>  21
<211>  249
<212>  PRT
<213>  Methanothermobacter wolfeii

<400>  21

Met Lys Cys Gln Val Phe Glu Asn Pro Ser Pro Lys Lys Ala Tyr Arg 
1               5                   10                  15      


Val Ile Glu Glu Gly Ile Arg Lys Arg Val Leu Ile Val Ile Leu Ala 
            20                  25                  30          


Cys Cys Ser Ala Ser Tyr Glu Gly Arg Ala Arg Ser Arg Leu Glu Pro 
        35                  40                  45              


Gly Glu Arg Leu Ile Val Ile Lys Pro Asp Gly Thr Phe Met Ile His 
    50                  55                  60                  


Gln Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Arg Ser Arg 
65                  70                  75                  80  


Cys Arg Ser Tyr Met Lys Gly Gly Lys Leu Tyr Leu Glu Ser Ile Arg 
                85                  90                  95      


Arg Ser Pro Glu Glu Arg Leu Glu Val Glu Ile His Glu Ala His Leu 
            100                 105                 110         


Val Ser Cys Tyr Thr Ala Arg Asp Arg His Glu Leu Glu Val Ala Gly 
        115                 120                 125             


His Glu Arg Asp Met Gly Asp Met Ile Met Glu His Pro His Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Val Ala Arg Glu Tyr Ser Thr Asp Ala Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Val Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Asp Glu Phe Arg Asp Asp Arg Arg Gly Val Arg Gly Met 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Met Glu Met Leu Glu Asp 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Ser Leu Glu Pro Leu Arg Glu Leu Arg Ser 
225                 230                 235                 240 


Ala Arg Gly Val Thr Leu Asp Asn Phe 
                245                 


<210>  22
<211>  249
<212>  PRT
<213>  Methanobacteriaceae archaeon

<400>  22

Met Arg Phe Ile Ser Leu Glu Asn Pro Thr Ser Glu Glu Ser Cys Arg 
1               5                   10                  15      


Ile Ile Lys Glu Gly Leu Arg Lys Lys Ala Met Ile Ile Ile Phe Ser 
            20                  25                  30          


Cys Cys Lys Val Arg Tyr Tyr Gly Arg Ala Lys Ser Arg Leu Gly Pro 
        35                  40                  45              


Gly Glu Arg Leu Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Asp Arg Lys Val Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Lys 
65                  70                  75                  80  


Ala Lys Val Lys Ile Glu Asp Gly Lys Ile Leu Val Glu Ser Ile Arg 
                85                  90                  95      


Arg Lys Pro Ala Glu Lys Leu Met Val Glu Met Glu Lys Val His Thr 
            100                 105                 110         


Leu Ser Tyr Tyr Leu Val Lys Asp Val His Glu Leu Glu Val Ala Gly 
        115                 120                 125             


His Glu Glu Asp Met Arg Arg Leu Ile Leu Glu Ser Pro Asp Ile Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Ile Thr Arg Glu Tyr Gln Thr Ser Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Arg Ala Gly Val Ser Ala Val Arg Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Glu Asp Phe Lys Asp Asp Lys His Gly Val Arg Gly Val 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Arg Glu Leu Leu Glu Ala 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Ser Leu Glu Pro Pro Arg Glu Leu Lys Lys 
225                 230                 235                 240 


Gly Tyr Lys Met Thr Leu Asp Lys Phe 
                245                 


<210>  23
<211>  249
<212>  PRT
<213>  Methanothermobacter thermautotrophicus

<400>  23

Met Lys Cys Lys Val Ser Glu Asn Pro Ser Ile Lys Glu Ala Tyr Arg 
1               5                   10                  15      


Leu Ile Glu Asp Gly Ile Arg Lys Arg Ala Leu Val Val Ile Leu Ala 
            20                  25                  30          


Cys Cys Ser Ala Ser Tyr Glu Gly Arg Ala Arg Ser Arg Leu Asp Ala 
        35                  40                  45              


Gly Glu Arg Leu Ile Val Ile Lys Pro Asp Gly Thr Phe Met Val His 
    50                  55                  60                  


Gln Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Ser Arg Ala Tyr Ile Lys Arg Gly Ser Leu Tyr Leu Glu Ser Ile Arg 
                85                  90                  95      


Arg Asp Pro Glu Glu Arg Leu Glu Val Glu Ile His Glu Ala His Leu 
            100                 105                 110         


Val Ser Tyr Tyr Leu Ala Arg Asp Val His Asp Leu Met Val Ala Gly 
        115                 120                 125             


His Glu Asn Asp Met Gly Asp Met Ile Ile Met His Pro His Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Val Ala Arg Glu Tyr Ala Val Thr Ser Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Met Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Glu Phe Arg Glu Asp Arg Val Gly Val Arg Gly Val 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Met Glu Met Leu Glu Glu 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Glu Ile Glu Pro Pro Arg Glu Leu Arg Ser 
225                 230                 235                 240 


Asn Arg Gly Val Thr Leu Asp Asn Phe 
                245                 


<210>  24
<211>  249
<212>  PRT
<213>  Methanothermobacter thermautotrophicus str. Delta H

<400>  24

Met Lys Cys Lys Val Ser Glu Asn Pro Ser Ile Lys Glu Ala Tyr Arg 
1               5                   10                  15      


Leu Ile Glu Asp Gly Ile Arg Lys Arg Ala Leu Val Val Ile Leu Ala 
            20                  25                  30          


Cys Cys Ser Ala Ser Tyr Glu Gly Arg Ala Arg Ser Arg Leu Asp Ala 
        35                  40                  45              


Gly Glu Arg Leu Ile Val Ile Lys Pro Asp Gly Thr Phe Met Val His 
    50                  55                  60                  


Gln Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Lys Ser Arg 
65                  70                  75                  80  


Ser Arg Ala Tyr Ile Lys Arg Gly Ser Leu Tyr Leu Glu Ser Ile Arg 
                85                  90                  95      


Arg Asp Pro Glu Glu Arg Leu Glu Val Glu Ile His Glu Ala His Leu 
            100                 105                 110         


Val Ser Tyr Tyr Leu Ala Arg Asp Val His Asp Leu Met Val Ala Gly 
        115                 120                 125             


His Glu Asn Asp Met Gly Asp Met Ile Ile Met His Pro His Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Val Ala Arg Glu Tyr Ala Val Thr Ser Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Met Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Glu Phe Arg Glu Asp Arg Val Gly Val Arg Gly Val 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Met Glu Met Leu Glu Glu 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Glu Ile Glu Pro Pro Arg Glu Leu Arg Ser 
225                 230                 235                 240 


Asn Arg Gly Val Thr Leu Asp Asn Phe 
                245                 


<210>  25
<211>  249
<212>  PRT
<213>  Methanothermobacter

<400>  25

Met Lys Cys Arg Val Ser Glu Asn Pro Ser Arg Asn Glu Ala Tyr Gln 
1               5                   10                  15      


Leu Leu Glu Glu Gly Ile Arg Lys Arg Ser Leu Ile Val Ile Leu Ala 
            20                  25                  30          


Cys Cys Ser Ala Ser Tyr Glu Gly Arg Ala Arg Ser Ser Leu Gly Ala 
        35                  40                  45              


Gly Glu Arg Leu Ile Val Ile Lys Pro Asp Gly Thr Phe Met Val His 
    50                  55                  60                  


Gln Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Arg Ser Arg 
65                  70                  75                  80  


Cys Arg Val Tyr Met Lys Arg Gly Ser Leu Phe Leu Glu Ser Ile Arg 
                85                  90                  95      


Arg Ser Pro Glu Glu Arg Leu Glu Val Glu Leu His Glu Ile His Leu 
            100                 105                 110         


Ile Ser Ser Tyr Leu Pro Arg Asp Met His Glu Leu Thr Val Ser Gly 
        115                 120                 125             


His Glu Ser Asp Met Gly Asp Met Ile Ile Met His Pro His Leu Ile 
    130                 135                 140                 


Glu Pro Gly Phe Arg Pro Val Ala Arg Glu Tyr Ala Thr Ser Ser Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Met Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Arg 
            180                 185                 190         


Arg Tyr Val Asp Glu Phe Arg Asp Asp Arg Val Gly Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Leu Glu Met Leu Glu Asp 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Glu Ile Glu Pro Pro Arg Glu Leu Lys Ser 
225                 230                 235                 240 


Asn Arg Gly Val Thr Leu Asp Asn Phe 
                245                 


<210>  26
<211>  248
<212>  PRT
<213>  Methanothermobacter

<400>  26

Arg Phe Lys Thr Ile Glu Asn Pro Ser Pro Lys Glu Ser His Glu Leu 
1               5                   10                  15      


Ile Ser Glu Gly Leu Arg Lys Lys Ala Met Ile Ile Leu Phe Ala Cys 
            20                  25                  30          


Cys Lys Val Gln Tyr His Gly Arg Ala Lys Ser Arg Leu Gly Thr Gly 
        35                  40                  45              


Glu Arg Leu Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Thr 
65                  70                  75                  80  


Lys Ile Lys Ile Glu Asn Gly Lys Ile Leu Leu Glu Ser Arg Arg Arg 
                85                  90                  95      


Lys Pro Pro Glu Lys Leu Thr Ala Glu Ile Lys Arg Ile His Ser Leu 
            100                 105                 110         


Ser Tyr His Leu Ala Arg Asp Ala His Glu Leu Gln Val Thr Gly His 
        115                 120                 125             


Glu Glu Asp Met Arg Gln Leu Ile Leu Glu Ser Pro Asp Ile Ile Glu 
    130                 135                 140                 


Lys Gly Phe Arg Pro Thr Thr Ser Glu Tyr Pro Thr Ser Asn Gly Phe 
145                 150                 155                 160 


Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Ser Leu Met Ile Leu Glu 
                165                 170                 175     


Leu Lys Ser Arg Arg Ala Gly Leu Asn Ala Val Arg Gln Leu Lys Arg 
            180                 185                 190         


Tyr Leu Lys Asp Phe Lys Asp Asp Lys His Gly Val Arg Gly Val Leu 
        195                 200                 205             


Val Ala Pro Ser Ile Thr His Asp Ala Lys Glu Leu Leu Glu Lys Glu 
    210                 215                 220                 


Gly Leu Glu Phe Lys Ser Leu Lys Pro Pro Gln Glu Leu Lys Lys Asp 
225                 230                 235                 240 


His Lys Ile Thr Leu Asp Lys Phe 
                245             


<210>  27
<211>  249
<212>  PRT
<213>  Methanothermobacter marburgensis

<400>  27

Met Lys Cys Arg Val Ser Glu Asn Pro Ser Arg Ser Glu Ala Tyr Arg 
1               5                   10                  15      


Leu Leu Glu Glu Gly Ile Arg Lys Arg Ser Leu Ile Val Ile Leu Ala 
            20                  25                  30          


Cys Cys Ser Ala Ser Tyr Glu Gly Arg Ala Arg Ser Ser Leu Gly Ala 
        35                  40                  45              


Gly Glu Arg Leu Ile Val Ile Lys Pro Asp Gly Thr Phe Met Val His 
    50                  55                  60                  


Gln Asp Arg Lys Val Asp Pro Val Asn Trp Gln Pro Pro Arg Ser Arg 
65                  70                  75                  80  


Cys Arg Val Tyr Met Lys Gln Lys Ser Leu Phe Leu Glu Ser Ile Arg 
                85                  90                  95      


Arg Ser Pro Glu Glu Arg Leu Glu Val Glu Leu His Glu Val His Leu 
            100                 105                 110         


Ile Ser Phe Tyr Leu Pro Arg Asp Met His Glu Leu Thr Val Ser Gly 
        115                 120                 125             


His Glu Ser Asp Met Gly Asp Met Ile Ile Met His Pro His Leu Ile 
    130                 135                 140                 


Glu Pro Gly Phe Arg Pro Val Ala Arg Glu Tyr Ala Thr Ser Ser Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Glu Asn Gly Ser Leu Met Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Ser Ala Val Lys Gln Leu Arg 
            180                 185                 190         


Arg Tyr Val Asp Glu Phe Arg Asp Asp Gln Val Gly Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr His Asp Ala Leu Glu Met Leu Glu Asp 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Glu Ile Glu Pro Pro Arg Glu Leu Lys Ser 
225                 230                 235                 240 


Asn Arg Gly Val Thr Leu Asp Asn Phe 
                245                 


<210>  28
<211>  249
<212>  PRT
<213>  Methanobacterium

<400>  28

Met Ile Ile Lys Leu Asp Glu Asn Pro Gly Thr Glu Glu Val Phe Asp 
1               5                   10                  15      


Phe Ile Asn Glu Ala Ile Ser Lys Arg Ala Phe Ile Ile Ile Val Ala 
            20                  25                  30          


Cys Cys Arg Ile Lys Tyr Arg Gly Arg Ala Thr Ser Arg Leu Gly Ser 
        35                  40                  45              


Gly Asp Arg Thr Ile Ile Ile Lys Thr Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Asp Tyr Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Asn Cys Lys 
65                  70                  75                  80  


Phe Lys Thr Arg Met Glu Asn Gly Arg Val Tyr Leu Cys Gly Val Arg 
                85                  90                  95      


Arg Asn Pro Pro Glu Ser Leu Glu Val Glu Ile Cys Lys Thr His Met 
            100                 105                 110         


Ile Ser Tyr His Ile Gly Lys Asp Ile Lys Lys Leu Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Glu Asp Met Arg Ala Met Ile Met Glu Ser Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Ser Lys Glu Tyr Pro Val Ser Thr Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Ser Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Gln Ala Gly Ile Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Lys Tyr Phe Glu Asp Phe Thr Asp His Lys Asp Phe Val Arg Gly Leu 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Glu Asp Ala Gln Glu Leu Leu Glu Lys 
    210                 215                 220                 


Tyr Gln Leu Glu Phe Lys Ala Leu Glu Pro Pro Lys Glu Leu Lys Ser 
225                 230                 235                 240 


Ala Lys Ser Val Thr Leu Asp Phe Phe 
                245                 


<210>  29
<211>  249
<212>  PRT
<213>  Methanobacterium paludis

<400>  29

Met Lys Phe Leu Ser Glu Lys Asn Pro Asp Ile Lys Arg Thr Tyr Glu 
1               5                   10                  15      


Ile Ile Asn Glu Gly Ile Ser Lys Arg Ala Val Ile Val Ile Met Ala 
            20                  25                  30          


Cys Cys Ser Val Leu Tyr Glu Gly Arg Ala Arg Ser Arg Leu Ala Asp 
        35                  40                  45              


Gly Asp Arg Met Val Met Ile Lys Thr Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Asp Arg Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Gln 
65                  70                  75                  80  


Cys Lys Ala Ser Leu Lys Glu Gly Leu Leu His Ile Glu Gly Ala Arg 
                85                  90                  95      


Arg Asn Pro Pro Glu Arg Leu Glu Val Glu Ile His Ser Thr Tyr Met 
            100                 105                 110         


Ala Ser Tyr Phe Ile Gly Glu Asp Ser Lys Asp Leu Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Ala Asp Met Val Asp Met Ala Phe Glu Ser Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Ser Arg Glu Tyr Ser Thr Glu Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Gln Asp Gly Asn Leu Met Val Leu 
                165                 170                 175     


Glu Phe Lys Ser Arg Arg Ala Gly Ile Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Asp Cys Phe Ala Asp His Lys Gln Phe Val Arg Gly Leu 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Asp Asp Ala Ser Asp Leu Leu Lys Glu 
    210                 215                 220                 


Tyr Lys Leu Glu Phe Lys Glu Leu Glu Pro Pro Met Glu Phe Asp Gly 
225                 230                 235                 240 


Asp Lys Asn Leu Thr Leu Asp Phe Phe 
                245                 


<210>  30
<211>  249
<212>  PRT
<213>  Methanobacterium

<400>  30

Met Ile Ile Lys Leu Asp Glu Asn Pro Gly Thr Glu Glu Val Phe Asp 
1               5                   10                  15      


Phe Ile Asn Glu Ala Ile Ser Lys Arg Ala Phe Ile Ile Ile Val Ala 
            20                  25                  30          


Cys Cys Arg Ile Lys Tyr Arg Gly Arg Ala Thr Ser Arg Leu Gly Ser 
        35                  40                  45              


Gly Asp Arg Thr Ile Ile Ile Lys Thr Asp Gly Ser Phe Leu Val His 
    50                  55                  60                  


Gln Asp Tyr Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Asn Cys Lys 
65                  70                  75                  80  


Phe Lys Thr Arg Met Glu Asn Asp Arg Val Tyr Ile Cys Gly Val Arg 
                85                  90                  95      


Arg Asn Pro Pro Glu Ser Leu Glu Val Glu Ile Cys Lys Thr His Met 
            100                 105                 110         


Ile Ser Tyr His Ile Gly Lys Asp Ile Lys Lys Leu Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Glu Asp Leu Arg Thr Met Ile Met Glu Ser Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Ser Lys Glu Tyr Gln Val Ser Thr Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Ser Leu Met Ile Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Gln Ala Gly Val Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Lys Tyr Phe Glu Asp Phe Thr Asp His Lys Asp Phe Val Arg Gly Leu 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Glu Asp Ala Gln Glu Leu Leu Glu Lys 
    210                 215                 220                 


Tyr Gln Leu Glu Phe Lys Ala Leu Glu Pro Pro Lys Glu Leu Lys Ser 
225                 230                 235                 240 


Ala Lys Ser Val Thr Leu Asp Phe Phe 
                245                 


<210>  31
<211>  248
<212>  PRT
<213>  Palaeococcus ferrophilus

<400>  31

Met Lys Leu Arg Ala Leu Glu Asn Pro Ser Ala Glu Glu Leu Glu Ser 
1               5                   10                  15      


Ile Ile Ser Glu Gly Leu Ser Ser Glu Ala Ile Ile Thr Ile Phe Ala 
            20                  25                  30          


Arg Cys Arg Val Tyr Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Glu 
        35                  40                  45              


Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Arg Asn Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Val Phe Phe Glu Arg Glu Lys Leu Arg Leu Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Leu Lys Val Tyr Leu Ala Thr 
            100                 105                 110         


Tyr Phe Gln Ala Glu Asp Ser Glu Glu Leu Thr Leu Ile Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Arg Asp Tyr Ile Phe Asp His Pro Glu Val Ile Glu Glu 
    130                 135                 140                 


Gly Phe Lys Pro Leu Phe Arg Glu Lys Pro Ile Lys His Gly Ile Val 
145                 150                 155                 160 


Asp Ile Phe Gly Arg Asp Arg Asp Gly Asn Ile Val Ile Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Asp Met Arg Glu Glu Tyr Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Val Lys Pro Pro Lys Gly Glu Arg Lys Lys Gly 
225                 230                 235                 240 


Lys Gln Lys Thr Leu Asp Ser Phe 
                245             


<210>  32
<211>  243
<212>  PRT
<213>  Methanobacterium

<400>  32

Lys Asn Pro Asp Thr Gln Arg Val Leu Glu Ile Ile Asn Glu Gly Leu 
1               5                   10                  15      


Ser Lys Arg Ala Val Ile Thr Ile Met Ala Cys Cys Arg Val Asp Tyr 
            20                  25                  30          


Asn Gly Arg Ala Val Ser Arg Leu Gly Leu Gly Asp Arg Ile Ile Ile 
        35                  40                  45              


Ile Lys Ala Asp Gly Ser Phe Leu Ile His Gln Asp Arg Asn Leu Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Lys Thr Lys Val Ser Ala Asp Ile Tyr 
65                  70                  75                  80  


Gln Gly Met Val Lys Ile Lys Gly Val Arg Arg Asn Pro His Glu Ser 
                85                  90                  95      


Leu Glu Val Lys Ile Leu Gln Thr His Met Ile Ser Tyr Phe Ile Gly 
            100                 105                 110         


Glu Asp Ser Glu Asn Leu Glu Leu Ala Gly Tyr Glu Ala Asp Met Gly 
        115                 120                 125             


Asp Leu Ile Phe Lys Asp Pro Asp Val Phe Glu Lys Gly Phe Arg Pro 
    130                 135                 140                 


Thr Ser Arg Glu Tyr His Thr Pro Gln Gly Phe Ile Asp Ile Leu Gly 
145                 150                 155                 160 


Lys Asp Gln Asp Gly Asn Ile Thr Ile Leu Glu Leu Lys Ser Arg Lys 
                165                 170                 175     


Ala Gly Val Asn Ala Val Lys Gln Leu Arg Arg Tyr Leu Asp Cys Phe 
            180                 185                 190         


Ser Asp His Lys Glu Lys Val Arg Gly Val Leu Val Ala Pro Ser Ala 
        195                 200                 205             


Thr Asp Asp Ala Leu Glu Leu Leu Glu Lys Gln Gly Met Glu Phe Lys 
    210                 215                 220                 


Ala Leu Glu Pro Pro Arg Glu Leu Asn Asn Glu Lys Val Val Thr Leu 
225                 230                 235                 240 


Glu Asn Phe 
            


<210>  33
<211>  244
<212>  PRT
<213>  Pyrococcus abyssi

<400>  33

Ile Lys Glu Asn Pro Ser Glu Glu Glu Ile Lys Glu Leu Leu Asp Leu 
1               5                   10                  15      


Ala Glu Lys His Gly Gly Val Val Thr Ile Phe Ala Arg Cys Lys Val 
            20                  25                  30          


His Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile 
        35                  40                  45              


Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys 
    50                  55                  60                  


Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Thr Phe Lys 
65                  70                  75                  80  


Glu Asn Ser Ile Ile Ser Ile Arg Arg Arg Pro Tyr Glu Arg Leu Glu 
                85                  90                  95      


Val Glu Ile Ile Glu Pro Tyr Ser Leu Val Val Phe Leu Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Asn Leu 
        115                 120                 125             


Ile Phe Glu Asn Pro Arg Val Ile Glu Glu Gly Phe Lys Pro Ile Tyr 
    130                 135                 140                 


Arg Glu Lys Pro Ile Arg His Gly Ile Val Asp Val Met Gly Val Asp 
145                 150                 155                 160 


Lys Asp Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ser Leu Lys Glu 
            180                 185                 190         


Glu Tyr Gly Glu Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr 
        195                 200                 205             


Glu Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys 
    210                 215                 220                 


Leu Glu Pro Pro Lys Lys Gly Asn Glu Lys Arg Ser Lys Gln Lys Thr 
225                 230                 235                 240 


Leu Asp Phe Phe 
                


<210>  34
<211>  249
<212>  PRT
<213>  Methanobacterium congolense

<400>  34

Met Lys Phe Leu Ser Glu Lys Asn Pro Asp Ile His Arg Thr Tyr Glu 
1               5                   10                  15      


Ile Ile Asn Glu Gly Ile Ser Lys Arg Ala Phe Val Val Leu Met Ala 
            20                  25                  30          


Cys Cys Lys Val Leu Tyr Gln Gly Arg Ala Lys Ser Arg Leu Gly Ser 
        35                  40                  45              


Gly Asp Arg Phe Ile Ile Ile Lys Pro Asp Gly Ser Phe Met Val His 
    50                  55                  60                  


Gln Asp Arg Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Asn 
65                  70                  75                  80  


Cys Lys Ala Ser Leu Glu Asn Gly Ile Leu Gln Ile Thr Gly Ser Arg 
                85                  90                  95      


Arg Asn Pro Pro Glu Ser Leu Glu Val Glu Ile His Cys Thr Tyr Met 
            100                 105                 110         


Ala Ser Tyr Phe Ile Gly Glu Asp Ser Lys Glu Leu Glu Ile Ala Gly 
        115                 120                 125             


Tyr Glu Glu Asn Met Arg Glu Met Val Phe Glu Ser Pro Glu Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Arg Pro Thr Ser Arg Glu Tyr Gln Thr Glu Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Ala Leu Met Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Arg Ala Gly Val Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Lys Tyr Leu Asp Cys Phe Thr Asp His Lys Glu Phe Val Arg Gly Val 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Asp Asp Ala Met Glu Leu Leu Lys Glu 
    210                 215                 220                 


Tyr Gln Leu Glu Phe Lys Glu Leu His Pro Pro Met Glu Leu Gly Gly 
225                 230                 235                 240 


Gly Lys Asn Leu Thr Leu Asp Phe Phe 
                245                 


<210>  35
<211>  249
<212>  PRT
<213>  Methanobacterium

<400>  35

Met Lys Phe Leu Ser Glu Lys Asn Pro Asp Gln Gln Arg Thr Phe Glu 
1               5                   10                  15      


Ile Ile Asn Glu Gly Leu Ser Lys Lys Ala Val Ile Val Leu Met Val 
            20                  25                  30          


Cys Cys Arg Val Ile Tyr Glu Gly Arg Ala Arg Ser Lys Leu Ala Ser 
        35                  40                  45              


Gly Asp Arg Met Ile Ile Ile Lys Ser Asp Gly Ser Phe Met Ile His 
    50                  55                  60                  


Gln Asp Arg Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Gln 
65                  70                  75                  80  


Cys Lys Ala Ser Leu Lys Lys Gly Ile Met Tyr Ile Glu Gly Lys Arg 
                85                  90                  95      


Arg Asn Pro Pro Glu Arg Leu Glu Val Glu Ile His Asn Thr Tyr Ile 
            100                 105                 110         


Ala Ser Tyr Phe Asn Gly Glu Asp Ser Lys Asp Leu Glu Leu Thr Gly 
        115                 120                 125             


Tyr Glu Glu Asn Met Arg Glu Leu Val Phe Glu Asn Pro Glu Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Arg Pro Ser Asn Arg Glu Tyr Ser Thr Pro Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Val Leu Gly Lys Asp Lys Asn Gly Asn Leu Met Val Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Arg Ala Gly Ile Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Lys Tyr Leu Asp Cys Phe Ser Asp His Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Gly Asp Ala Glu Glu Leu Leu Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Glu Tyr Lys Ser Leu Glu Pro Pro Arg Glu Phe Gly Asn 
225                 230                 235                 240 


Asp Lys Asn Leu Thr Leu Asp Phe Phe 
                245                 


<210>  36
<211>  242
<212>  PRT
<213>  Methanobacterium

<400>  36

Asn Pro Asp Thr Glu Leu Val Leu Glu Ile Ile Thr Glu Gly Ile Ser 
1               5                   10                  15      


Lys Arg Ala Phe Ile Thr Ile Met Ala Ser Cys Arg Val Tyr Tyr Glu 
            20                  25                  30          


Gly Arg Ala Thr Ser Arg Leu Glu Leu Gly Asp Arg Ile Ile Leu Ile 
        35                  40                  45              


Lys Ser Asp Gly Ser Phe Ile Ile His Gln Asp Arg Asn Leu Glu Pro 
    50                  55                  60                  


Val Asn Trp Gln Pro Pro Lys Thr Lys Val Thr Val Asn Ile His Gln 
65                  70                  75                  80  


Gly Met Val Lys Leu Lys Gly Val Arg Arg Ser Pro Ser Glu Ser Leu 
                85                  90                  95      


Glu Val Glu Ile Leu Gln Thr His Leu Ala Ser Tyr Phe Ile Gly Glu 
            100                 105                 110         


Asp Ser Glu Ser Leu Glu Leu Ala Gly Tyr Glu Ala Asp Met Gly Asp 
        115                 120                 125             


Leu Ile Phe Lys Asp Pro Glu Val Ile Glu Lys Gly Phe Arg Pro Thr 
    130                 135                 140                 


Ser Arg Glu Tyr His Thr Pro Gln Gly Phe Ile Asp Ile Met Gly Lys 
145                 150                 155                 160 


Asp His Glu Gly Asn Ile Thr Ile Leu Glu Leu Lys Ser Arg Lys Ala 
                165                 170                 175     


Gly Thr Asn Ala Val Lys Gln Leu Arg Arg Tyr Val Asp Cys Phe Cys 
            180                 185                 190         


Asp His Lys Glu Lys Val Arg Gly Val Leu Val Ala Pro Ser Ala Thr 
        195                 200                 205             


Asp Asp Ala Leu Glu Met Leu Glu Glu Gln Gly Met Glu Phe Lys Ala 
    210                 215                 220                 


Leu Glu Ala Pro Arg Glu Leu Lys Asn Asn Lys Ile Val Thr Leu Glu 
225                 230                 235                 240 


Ser Phe 
        


<210>  37
<211>  244
<212>  PRT
<213>  Pyrococcus Abyssi


<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Ile Lys Glu Asn Pro Ser Glu Glu Glu Ile Lys Glu Leu Leu Asp Leu 
1               5                   10                  15      


Ala Glu Lys His Gly Gly Val Val Thr Ile Phe Ala Arg Cys Lys Val 
            20                  25                  30          


His Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile 
        35                  40                  45              


Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys 
    50                  55                  60                  


Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Thr Phe Lys 
65                  70                  75                  80  


Glu Asn Ser Xaa Ile Ser Ile Arg Arg Arg Pro Tyr Glu Arg Leu Glu 
                85                  90                  95      


Val Glu Ile Ile Glu Pro Tyr Ser Leu Val Val Phe Leu Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Xaa Ala Asn Leu 
        115                 120                 125             


Ile Phe Glu Asn Pro Arg Val Ile Glu Glu Gly Phe Lys Pro Ile Tyr 
    130                 135                 140                 


Arg Glu Lys Pro Ile Arg His Gly Ile Val Asp Val Xaa Gly Val Asp 
145                 150                 155                 160 


Lys Asp Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Xaa Lys Arg Tyr Val Asp Ser Leu Lys Glu 
            180                 185                 190         


Glu Tyr Gly Glu Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr 
        195                 200                 205             


Glu Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys 
    210                 215                 220                 


Leu Glu Pro Pro Lys Lys Gly Asn Glu Lys Arg Ser Lys Gln Lys Thr 
225                 230                 235                 240 


Leu Asp Phe Phe 
                


<210>  38
<211>  249
<212>  PRT
<213>  Methanosphaera

<400>  38

Met Lys Phe Lys Thr Ile Glu Asn Pro Glu Asn Asn Asp Ala Tyr Thr 
1               5                   10                  15      


Leu Leu Gln Glu Gly Phe Asp Lys Lys Ala Met Ile Ile Val Leu Ala 
            20                  25                  30          


Glu Cys His Val Glu Tyr Glu Gly Arg Ala Arg Ser Arg Leu Asp Ile 
        35                  40                  45              


Gly Asp Arg Leu Ile Leu Ile Lys Lys Asp Gly Thr Phe Val Ile His 
    50                  55                  60                  


Gln Glu Leu Asn Leu Asp Pro Val Asn Trp Gln Ala Pro Gly Cys Lys 
65                  70                  75                  80  


Asn Lys Val Lys Leu Glu Asp Asn His Val Met Leu Ile Ser Lys Lys 
                85                  90                  95      


Thr Lys Pro Thr Glu Glu Ile Lys Val Phe Leu Asp Thr Ile Tyr Asn 
            100                 105                 110         


Ile Thr Tyr Tyr Asn Cys Leu Asp Thr Lys Asn Leu Glu Ile Arg Gly 
        115                 120                 125             


Tyr Glu Lys His Met Val Asp Leu Ala Trp Glu Lys Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Arg Arg Glu Tyr Gln Thr Glu Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Leu Met Gly Thr Asp Ile Asp Glu Lys Leu Met Ile Leu 
                165                 170                 175     


Glu Phe Lys Ser Arg Lys Ala Gly Thr Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Gly Tyr Ile Asp Cys Phe Lys Asp Asn Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Ile Val Ala Pro Asp Ile Thr Asp Asn Ala Arg Glu Leu Leu Glu Ser 
    210                 215                 220                 


Leu Gln Met Glu Phe Ile Ser Met Asn Pro Pro Leu Asp Leu Leu Lys 
225                 230                 235                 240 


Gln Lys Ala Ser Thr Leu Asp Ser Phe 
                245                 


<210>  39
<211>  250
<212>  PRT
<213>  Methanobacterium

<400>  39

Val Lys Phe Lys Val Glu Glu Asn Pro Ser Ile Glu Lys Thr Asn Glu 
1               5                   10                  15      


Leu Leu Lys Asp Gly Leu Lys Asn Lys Ala Ile Ile Ile Ile Thr Ala 
            20                  25                  30          


Cys Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Asn Leu Glu Leu 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Lys Ser Glu Lys Arg Asn Pro Val Asn Trp Gln Pro Pro Gly Cys Thr 
65                  70                  75                  80  


Val Lys Phe Lys Val Lys Asp Asp Leu Met Leu Ile Arg Ser Ile Arg 
                85                  90                  95      


Lys Asn Pro Lys Glu Ile Leu Asp Val Glu Ile Ser Lys Thr Tyr Met 
            100                 105                 110         


Ala Thr Tyr Phe Val Ala Lys Asp Tyr Glu Glu Leu Asp Leu Ile Gly 
        115                 120                 125             


Ser Glu Glu Asp Met Ala Asn Leu Ile Phe Tyr Glu Asn Pro Glu Val 
    130                 135                 140                 


Ile Glu Glu Gly Phe Lys Pro Ile Ala Lys Glu Lys Ser Ile Ser Asn 
145                 150                 155                 160 


Gly Val Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Asn Ile Met Val 
                165                 170                 175     


Leu Glu Leu Lys Arg Val Arg Gly Ser Leu Gly Ala Val Ser Gln Leu 
            180                 185                 190         


Lys Arg Tyr Val Asp Asn Leu Lys Glu Glu Asn Glu Gly Leu Arg Gly 
        195                 200                 205             


Met Leu Val Ala Pro Ser Ile Thr Asp Ser Ala Met Lys Leu Leu Lys 
    210                 215                 220                 


Glu Tyr Gly Leu Glu Phe Lys Glu Leu His Pro Pro Lys Lys Leu Lys 
225                 230                 235                 240 


Lys Glu Asp Ile Ile Lys Leu Asp Phe Phe 
                245                 250 


<210>  40
<211>  250
<212>  PRT
<213>  Methanobacterium

<400>  40

Val Lys Phe Lys Val Glu Glu Asn Pro Asp Ile Glu Lys Thr Asn Glu 
1               5                   10                  15      


Ile Leu Lys Asp Gly Leu Lys Asn Lys Ala Ile Ile Ile Ile Thr Ala 
            20                  25                  30          


Cys Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Asn Leu Glu Leu 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Lys Ser Glu Lys Arg Asn Pro Val Asn Trp Gln Pro Pro Gly Cys Thr 
65                  70                  75                  80  


Val Lys Phe Lys Val Lys Asp Asp Leu Met Leu Ile Arg Ser Ile Arg 
                85                  90                  95      


Lys Asn Pro Lys Glu Ile Leu Asp Val Glu Ile Ser Lys Thr Tyr Met 
            100                 105                 110         


Ala Thr Tyr Phe Val Ala Lys Asp Tyr Glu Glu Leu Asp Leu Ile Gly 
        115                 120                 125             


Ser Glu Glu Asp Met Ala Asn Leu Ile Phe Tyr Glu Asn Pro Glu Val 
    130                 135                 140                 


Ile Glu Glu Gly Phe Lys Pro Ile Ala Lys Glu Lys Ser Ile Ser Asn 
145                 150                 155                 160 


Gly Val Ile Asp Ile Leu Gly Lys Asp Lys Asn Gly Asn Ile Met Val 
                165                 170                 175     


Leu Glu Leu Lys Arg Val Arg Gly Ser Leu Gly Ala Val Ser Gln Leu 
            180                 185                 190         


Lys Arg Tyr Val Asp Asn Leu Lys Glu Glu Asn Glu Gly Leu Arg Gly 
        195                 200                 205             


Met Leu Val Ala Pro Ser Ile Thr Asp Ser Ala Met Lys Leu Leu Lys 
    210                 215                 220                 


Glu Tyr Gly Leu Glu Phe Lys Glu Leu His Pro Pro Lys Lys Leu Lys 
225                 230                 235                 240 


Lys Glu Asp Ile Ile Lys Leu Asp Phe Phe 
                245                 250 


<210>  41
<211>  249
<212>  PRT
<213>  Methanosphaera

<400>  41

Met Lys Tyr Lys Thr Ile Glu Asn Pro Ser Thr Gln Glu Ala Tyr Glu 
1               5                   10                  15      


Leu Ile Lys Asp Gly Phe Asn Lys Lys Ser Met Ile Ile Ile Leu Ala 
            20                  25                  30          


Gln Cys His Val Glu Tyr Glu Gly Arg Ala Arg Ser Arg Leu Asp Lys 
        35                  40                  45              


Gly Asp Arg Leu Ile Leu Ile Lys Lys Asp Gly Thr Phe Thr Ile His 
    50                  55                  60                  


Gln Glu Leu Asn Leu Asp Pro Val Asn Trp Gln Ala Pro Gly Cys Lys 
65                  70                  75                  80  


Asn Lys Val Ser Leu Lys Glu Asn Gln Ile Ile Leu Gln Ser Ile Lys 
                85                  90                  95      


Thr Lys Pro Asp Glu Glu Ile Thr Val Tyr Leu Asp Thr Val Tyr Cys 
            100                 105                 110         


Ala Thr Tyr Tyr Asn Cys Val Asp Thr Lys Asn Leu Glu Ile Arg Gly 
        115                 120                 125             


Tyr Glu Lys His Met Val Asp Leu Ala Trp Glu Lys Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Arg Arg Glu Tyr Gln Thr Glu Asn Gly 
145                 150                 155                 160 


Phe Ile Asp Leu Met Gly Thr Asp Lys Asp Glu Lys Leu Met Ile Leu 
                165                 170                 175     


Glu Phe Lys Ser Arg Lys Ala Gly Thr Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Gly Tyr Val Glu Cys Phe Met Asp Asn Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Ile Val Ala Pro Asp Ile Thr Asp Asn Ala Leu Glu Leu Leu Lys Ser 
    210                 215                 220                 


Leu Gln Met Glu Phe Ile Pro Leu Asn Pro Pro Lys Asp Leu Leu Thr 
225                 230                 235                 240 


Lys Lys Ala Ser Thr Leu Asp Ser Phe 
                245                 


<210>  42
<211>  249
<212>  PRT
<213>  Methanobacterium lacus

<400>  42

Met Lys Phe Leu Ser Glu Glu Asn Pro Asp His Gln Arg Thr Phe Glu 
1               5                   10                  15      


Ile Ile Asn Glu Gly Leu Ser Lys Lys Ala Val Val Val Val Val Ala 
            20                  25                  30          


Cys Cys Thr Val Asn Tyr Asp Gly Arg Ala Arg Ser Lys Leu Gly Ala 
        35                  40                  45              


Gly Asp Arg Met Val Met Ile Lys Ser Asp Gly Ser Phe Met Val His 
    50                  55                  60                  


Gln Asn Ile Asn Leu Glu Pro Val Asn Trp Gln Pro Pro Lys Ser Asn 
65                  70                  75                  80  


Cys Ser Ala Val Leu Lys Asp Gly Asn Ile Ile Leu Glu Gly Ser Arg 
                85                  90                  95      


Arg Ser Pro Pro Glu Arg Leu Gln Val Val Ile His Lys Thr Tyr Val 
            100                 105                 110         


Ala Ser Tyr Tyr Asn Gly Lys Asp Asn Lys Asp Leu Glu Leu Thr Gly 
        115                 120                 125             


Tyr Glu Glu Asn Met Arg Glu Met Ile Phe Lys Thr Pro Asp Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Arg Pro Ser Thr Lys Glu Tyr Pro Thr Ser Thr Gly 
145                 150                 155                 160 


Phe Ile Asp Val Leu Gly Lys Asp Lys Asn Gly Asn Val Val Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Arg Ala Gly Ile Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Leu Asp Asp Phe Ser Asp His Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Asp Asp Ala Ala Glu Leu Leu Glu Gly 
    210                 215                 220                 


Phe Lys Leu Glu Phe Lys Pro Leu Asp Pro Pro Arg Glu Phe Gly Ala 
225                 230                 235                 240 


Asp Lys Asn Leu Thr Leu Asp Phe Phe 
                245                 


<210>  43
<211>  249
<212>  PRT
<213>  Methanobacterium

<400>  43

Met Leu Ile Glu Ile Lys His Asn Pro Ser Asn Leu Glu Ser Met Glu 
1               5                   10                  15      


Ile Ile Asn Glu Ala Leu Ser Lys Arg Ala Phe Leu Ile Leu Val Leu 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Arg Ser Lys Leu Gly Leu 
        35                  40                  45              


Gly Glu Arg Thr Val Leu Ile Lys Gly Asp Gly Ser Phe Ile Ile His 
    50                  55                  60                  


Gln Asp Arg Asn Leu Glu Pro Ile Asn Trp Gln Pro Pro Lys Thr Lys 
65                  70                  75                  80  


Leu Ser Val Lys Leu Glu Asn Asp Val Ile Lys Ile Val Gly Met Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Gln Leu Glu Leu Ile Ile Ser Thr Val His Leu 
            100                 105                 110         


Ile Ser Tyr Tyr Phe Gly Ser Asp Thr Lys Asp Ile Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Glu Asp Met Arg His Met Ile Met Asn Asn Pro Asp Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Ser Lys Glu Tyr Gln Thr Pro Gln Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Tyr Gly Lys Asp Ala Asn Gly Lys Ile Val Ile Ile 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Ile Asn Ala Val Lys Gln Leu Lys 
            180                 185                 190         


Arg Tyr Ile Asn Cys Phe Leu Asp Asn Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Asp Asp Ala Arg Glu Leu Leu Glu Asn 
    210                 215                 220                 


Asn Lys Met Glu Tyr Ile Ser Leu Asp Pro Pro Lys Glu Leu Lys Thr 
225                 230                 235                 240 


Lys Thr Thr Thr Thr Leu Asp Tyr Phe 
                245                 


<210>  44
<211>  249
<212>  PRT
<213>  Methanobacterium

<400>  44

Met Leu Leu Lys Ile Glu His Asn Pro Thr Asn Leu Glu Ala Thr Glu 
1               5                   10                  15      


Leu Ile Asn Glu Ala Ile Ser Lys Arg Ala Phe Met Ile Leu Val Val 
            20                  25                  30          


Cys Cys Lys Val Asn Tyr Glu Gly Arg Ala Thr Ser Lys Leu Gly Phe 
        35                  40                  45              


Gly Glu Arg Thr Val Leu Ile Lys Gly Asp Gly Ser Phe Ile Ile His 
    50                  55                  60                  


Gln Asp Arg Asn Leu Glu Pro Ile Asn Trp Gln Pro Pro Arg Thr Lys 
65                  70                  75                  80  


Ile Gly Val Lys Leu Glu Asp Asp Val Ile Lys Ile Met Gly Lys Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Gln Leu Glu Leu Val Ile Arg Asn Val His Leu 
            100                 105                 110         


Ile Ser Tyr His Leu Gly Ser Asp Thr Lys Asp Ile Glu Leu Ala Gly 
        115                 120                 125             


Tyr Glu Glu Asp Met Arg Gln Met Ile Met Asp Asn Pro Glu Leu Ile 
    130                 135                 140                 


Glu Lys Gly Phe Arg Pro Thr Ser Lys Glu Tyr Gln Thr Pro Gln Gly 
145                 150                 155                 160 


Phe Ile Asp Ile Leu Gly Lys Asp Asp Ala Gly Lys Leu Val Val Leu 
                165                 170                 175     


Glu Leu Lys Ser Arg Lys Ala Gly Val Asn Ala Val Lys Gln Leu Leu 
            180                 185                 190         


Arg Tyr Val Asp Cys Phe Ser Asp Asn Lys Glu Phe Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ser Pro Ser Ile Thr Glu Glu Ala Lys Glu Ile Leu Asn Glu 
    210                 215                 220                 


Tyr Gln Met Glu His Ile Ser Leu Ser Pro Pro Lys Glu Leu Lys Val 
225                 230                 235                 240 


Lys Ser Ser Thr Thr Leu Asp Tyr Phe 
                245                 


<210>  45
<211>  251
<212>  PRT
<213>  Palaeococcus pacificus

<400>  45

Met Lys Val Lys Ser Lys Glu Asn Pro Ser Val Glu Glu Val Val Glu 
1               5                   10                  15      


Ile Leu Ser Glu Gly Leu Ser Asn Glu Ala Ile Ile Thr Leu Phe Ala 
            20                  25                  30          


His Cys Ser Val Phe Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Ala 
        35                  40                  45              


Gly Asp Arg Val Ile Met Ile Lys Pro Asp Gly Thr Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Val Pro Val Asn Trp Gln Pro Pro Gly Ser Ile 
65                  70                  75                  80  


Val Ser Phe Gln Ile Glu Glu Gly Lys Ile Lys Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu Leu Lys Val Tyr Leu 
            100                 105                 110         


Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Ala Leu Asn Leu Met Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Leu Gln Asn Pro Ser Ile Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Ala Leu Gln Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Ile Asp Ile Tyr Gly Val Asp Arg Asp Gly Asn Ile Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Ala Leu Lys Glu Glu His Gly Ser Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Glu Lys Leu Leu Lys Asp 
    210                 215                 220                 


Leu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro Lys Arg Glu Lys Ala 
225                 230                 235                 240 


Arg Lys Gly Lys Gln Lys Thr Leu Asp Met Leu 
                245                 250     


<210>  46
<211>  242
<212>  PRT
<213>  Methanobacterium formicicum

<400>  46

Asn Pro Asp Thr Pro Arg Val Leu Glu Ile Ile Asn Glu Gly Leu Ser 
1               5                   10                  15      


Lys Arg Ala Val Ile Thr Ile Met Ala Cys Cys Arg Val Asp Tyr Asp 
            20                  25                  30          


Gly Arg Ala Val Ser Arg Leu Gly Leu Gly Asp Arg Ile Ile Leu Ile 
        35                  40                  45              


Lys Ser Asp Gly Ser Phe Ile Ile His Gln Asp Arg Asn Leu Asp Pro 
    50                  55                  60                  


Val Asn Trp Gln Pro Pro Lys Thr Lys Val Thr Ala Asp Ile Tyr Gln 
65                  70                  75                  80  


Gly Met Val Lys Ile Lys Gly Val Arg Arg Asn Pro Ser Glu Ser Leu 
                85                  90                  95      


Glu Val Lys Ile Leu Gln Thr His Met Ile Ser Tyr Phe Ile Gly Glu 
            100                 105                 110         


Asp Ser Glu Ser Leu Glu Leu Ala Gly Tyr Glu Ala Asn Met Gly Asp 
        115                 120                 125             


Leu Ile Phe Lys Asp Pro Glu Val Phe Glu Lys Gly Phe Arg Pro Thr 
    130                 135                 140                 


Ser Arg Glu Tyr His Thr Pro Gln Gly Phe Ile Asp Ile Leu Gly Lys 
145                 150                 155                 160 


Asp Gln Asp Gly Asn Ile Thr Ile Leu Glu Leu Lys Ser Arg Lys Ala 
                165                 170                 175     


Gly Thr Asn Ala Val Lys Gln Leu Arg Arg Tyr Val Asp Cys Phe Ser 
            180                 185                 190         


Asp His Lys Glu Lys Val Arg Gly Val Leu Val Ala Pro Ser Ala Thr 
        195                 200                 205             


Asp Asp Ala Leu Glu Leu Leu Glu Glu Gln Gly Met Glu Phe Lys Ala 
    210                 215                 220                 


Leu Glu Pro Pro Arg Glu Leu Gly Thr Asp Lys Val Val Thr Leu Glu 
225                 230                 235                 240 


Asn Phe 
        


<210>  47
<211>  247
<212>  PRT
<213>  Pyrococcus kukulkanii

<400>  47

Lys Ile Val Val Arg Glu Asn Pro Thr Val Glu Asp Val Lys Glu Leu 
1               5                   10                  15      


Leu Glu Phe Ala Glu Lys His Asn Gly Met Val Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val Tyr Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly 
        35                  40                  45              


Asp Arg Ile Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Asn Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Lys Ile Glu Gly Asn Lys Val Val Ser Ile Arg Arg Lys Pro Arg Glu 
                85                  90                  95      


Lys Leu Glu Val Glu Leu Ile Glu Ser Tyr Ala Ile Thr Val Phe Leu 
            100                 105                 110         


Ala Glu Asp Tyr Glu Glu Leu Ser Leu Thr Gly Ser Glu Ala Glu Met 
        115                 120                 125             


Ala Lys Leu Ile Phe Glu Lys Pro Glu Val Ile Glu Glu Gly Phe Lys 
    130                 135                 140                 


Pro Met Phe Lys Glu Lys Pro Ile Lys His Gly Ile Val Asp Ile Leu 
145                 150                 155                 160 


Gly Val Asp Arg Glu Gly Asn Val Val Val Leu Glu Leu Lys Arg Arg 
                165                 170                 175     


Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ser 
            180                 185                 190         


Leu Lys Glu Glu Tyr Gly Asp Lys Val Arg Gly Ile Leu Val Ala Pro 
        195                 200                 205             


Ser Leu Thr Glu Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly Leu Glu 
    210                 215                 220                 


Phe Arg Lys Leu Glu Pro Pro Lys Arg Glu Ser Arg Lys Lys Ser Lys 
225                 230                 235                 240 


Gln Lys Thr Leu Asp Phe Phe 
                245         


<210>  48
<211>  247
<212>  PRT
<213>  Thermococcus guaymasensis

<400>  48

Lys Val Glu Leu Arg Glu Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu 
1               5                   10                  15      


Val Asp Ser Ala Val Ser Ser Glu Gly Ile Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Lys Pro Val Leu Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ile Thr 
            100                 105                 110         


Val Phe His Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Phe 
    130                 135                 140                 


Gly Phe Lys Pro Leu Tyr Arg Glu Lys Pro Ile Lys His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Arg Glu Gly Asn Ile Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Thr Leu Arg Glu Glu His Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Asp Arg Lys Ser Arg 
225                 230                 235                 240 


Gly Lys Gln Leu Lys Leu Phe 
                245         


<210>  49
<211>  247
<212>  PRT
<213>  Thermococcus eurythermalis

<400>  49

Lys Val Glu Leu Arg Glu Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu 
1               5                   10                  15      


Val Asp Ser Ala Val Ser Ser Glu Gly Val Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Lys Pro Val Leu Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ile Thr 
            100                 105                 110         


Val Phe His Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Tyr Arg Glu Lys Pro Ile Lys His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Arg Asp Gly Asn Leu Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Thr Leu Arg Glu Glu His Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Asp Arg Lys Ser Arg 
225                 230                 235                 240 


Gly Lys Gln Leu Lys Leu Phe 
                245         


<210>  50
<211>  247
<212>  PRT
<213>  Thermococcus nautili

<400>  50

Lys Val Glu Leu Arg Glu Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu 
1               5                   10                  15      


Val Asp Ser Ala Val Ser Ser Glu Gly Val Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Lys Pro Val Leu Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ile Thr 
            100                 105                 110         


Val Phe His Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Tyr Arg Glu Lys Pro Ile Lys His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Lys Asp Gly Asn Leu Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Thr Leu Arg Glu Glu His Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Gly Arg Lys Ser Arg 
225                 230                 235                 240 


Gly Lys Gln Leu Lys Leu Phe 
                245         


<210>  51
<211>  247
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  51

Lys Val Glu Leu Arg Glu Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu 
1               5                   10                  15      


Val Asp Leu Ala Ile Ser Ser Glu Gly Val Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Lys Pro Val Leu Ile Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Asp Glu Val Tyr Leu Ile Thr 
            100                 105                 110         


Val Phe His Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Leu 
    130                 135                 140                 


Gly Phe Lys Pro Leu Tyr Arg Glu Lys Pro Ile Arg His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Arg Asp Gly Asn Leu Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Thr Leu Arg Glu Glu His Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Asp Gly Lys Ser Arg 
225                 230                 235                 240 


Gly Arg Gln Leu Arg Leu Phe 
                245         


<210>  52
<211>  247
<212>  PRT
<213>  Thermococcus

<400>  52

Lys Val Glu Leu Arg Glu Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu 
1               5                   10                  15      


Val Asp Ser Ala Val Ser Ser Glu Gly Val Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Lys Pro Val Leu Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ile Thr 
            100                 105                 110         


Val Phe His Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Tyr Arg Glu Lys Pro Ile Lys His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Lys Asp Gly Asn Leu Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Thr Leu Arg Glu Lys His Glu Asn Val Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Leu Thr Ser Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly 
    210                 215                 220                 


Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Gly Arg Lys Ser Lys 
225                 230                 235                 240 


Gly Arg Gln Leu Lys Leu Phe 
                245         


<210>  53
<211>  252
<212>  PRT
<213>  Methanotorris igneus

<400>  53

Lys Val Asn Tyr Leu Val Asn Pro Lys Ala Glu Asp Ile Val Glu Leu 
1               5                   10                  15      


Leu Ala Ser Gly Ile Val Asn Asp Ser Ile Leu Val Phe Phe Ala Phe 
            20                  25                  30          


Cys Arg Val Arg Tyr Asp Gly Arg Ala Lys Ser Glu Leu Glu Pro Gly 
        35                  40                  45              


Asp Arg Ile Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Val His Lys 
    50                  55                  60                  


Asn Thr Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val 
65                  70                  75                  80  


Ser Trp Glu Val His Asp Gly Lys Leu Val Leu Lys Ser Val Arg Lys 
                85                  90                  95      


Lys Pro Arg Glu Ile Leu Gln Val Glu Leu Ile Lys Val Tyr His Ala 
            100                 105                 110         


Cys Ser Phe Gln Cys Glu Asp Tyr Glu Glu Leu Ser Leu Thr Gly Ser 
        115                 120                 125             


Glu Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Ser Leu Ile Glu 
    130                 135                 140                 


Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys Gln Ile Asn His Gly Ile 
145                 150                 155                 160 


Ile Asp Ile Leu Gly Lys Asp Lys Ser Gly Arg Trp Val Val Ile Glu 
                165                 170                 175     


Leu Lys Arg Arg Arg Ala Asp Leu Gln Ala Val Ser Gln Leu Lys Arg 
            180                 185                 190         


Tyr Val Glu Cys Leu Lys Tyr Glu Tyr Gly Glu Gly Asn Ile Arg Gly 
        195                 200                 205             


Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu 
    210                 215                 220                 


Glu Glu Asn Leu Glu Phe Arg Glu Leu Lys Pro Pro Lys Lys Glu Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Lys Gln Thr Thr Leu Asp Phe Tyr 
                245                 250         


<210>  54
<211>  249
<212>  PRT
<213>  Thermococcus barophilus

<400>  54

Met Lys Val Glu Ala Lys Val Glu Pro Ser His Glu Glu Ile Ile Glu 
1               5                   10                  15      


Ile Leu Asp Lys Ala Leu Ser Val Glu Ala Ile Ile Thr Leu Phe Ala 
            20                  25                  30          


Tyr Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Asn Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val 
65                  70                  75                  80  


Val Ser Ile Val Leu Glu Asp Gly Arg Ile Met Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Lys Thr Tyr Leu 
            100                 105                 110         


Val Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Thr Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Lys Asp Lys His Gly Asn Leu Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Ser Leu Arg Glu Glu His Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ala Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro Lys Arg Glu Lys Arg 
225                 230                 235                 240 


Lys Lys Gly Lys Gln Lys Thr Leu Asp 
                245                 


<210>  55
<211>  249
<212>  PRT
<213>  Thermococcus barophilus

<400>  55

Met Lys Val Glu Ala Lys Val Gly Pro Ser His Glu Glu Ile Val Glu 
1               5                   10                  15      


Ile Leu Asn Lys Ala Leu Ser Val Glu Ala Ile Ile Thr Leu Phe Ala 
            20                  25                  30          


Tyr Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Asn Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val 
65                  70                  75                  80  


Val Ser Ile Val Leu Gly Asp Gly Arg Ile Met Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Lys Thr Tyr Leu 
            100                 105                 110         


Val Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Thr Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Lys Asp Lys His Gly Asn Leu Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Ser Leu Arg Glu Glu His Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ala Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro Lys Arg Glu Lys Arg 
225                 230                 235                 240 


Lys Lys Gly Lys Gln Lys Thr Leu Asp 
                245                 


<210>  56
<211>  242
<212>  PRT
<213>  Methanobacterium

<400>  56

Asn Pro Asp Thr Gln Arg Val Leu Asp Ile Ile Asn Glu Gly Leu Ser 
1               5                   10                  15      


Lys Arg Ala Val Ile Thr Ile Met Ala Ser Cys Arg Val Tyr Tyr Asp 
            20                  25                  30          


Gly Arg Ala Val Ser Arg Leu Glu Leu Gly Asp Arg Ile Ile Met Ile 
        35                  40                  45              


Lys Ser Asp Gly Ser Phe Ile Ile His Gln Asp Arg Asn Leu Glu Pro 
    50                  55                  60                  


Val Asn Trp Gln Pro Pro Lys Thr Lys Val Thr Val Asp Thr His Gln 
65                  70                  75                  80  


Gly Met Val Lys Ile Arg Gly Val Arg Arg Ser Pro Ser Glu Ser Leu 
                85                  90                  95      


Glu Val Glu Ile Leu Gln Thr His Leu Val Ser Tyr Phe Ile Gly Glu 
            100                 105                 110         


Asp Val Glu Ser Leu Glu Leu Ala Gly Tyr Glu Ala Asn Met Gly Asp 
        115                 120                 125             


Leu Ile Phe Lys Asp Pro Glu Val Ile Glu Lys Gly Phe Arg Pro Thr 
    130                 135                 140                 


Ser Arg Glu Tyr His Thr Pro Gln Gly Phe Ile Asp Val Leu Gly Lys 
145                 150                 155                 160 


Asp Gln Asn Gly Asn Ile Thr Ile Leu Glu Leu Lys Ser Arg Lys Ala 
                165                 170                 175     


Gly Val Asn Ala Val Lys Gln Leu Arg Arg Tyr Val Asp Cys Phe Ser 
            180                 185                 190         


Asp His Lys Asp Thr Val Arg Gly Val Leu Val Ala Pro Ser Ile Thr 
        195                 200                 205             


Asp Asp Ala Arg Glu Leu Leu Glu Glu Gln Lys Met Glu Phe Lys Glu 
    210                 215                 220                 


Leu Glu Pro Pro Arg Glu Leu Gly Thr Asp Lys Val Val Thr Leu Glu 
225                 230                 235                 240 


Lys Phe 
        


<210>  57
<211>  249
<212>  PRT
<213>  Pyrococcus yayanosii

<400>  57

Lys Ala Glu Val Arg Met Glu Pro Thr Pro Lys Glu Leu Ala Glu Leu 
1               5                   10                  15      


Phe Asp Leu Ala Arg Lys Leu Glu Gly Met Leu Ile Ile Phe Ala Arg 
            20                  25                  30          


Cys Arg Val His Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly 
        35                  40                  45              


Asp Arg Ile Ile Met Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Lys Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Asn Val Pro Thr Ile Val Ser Val Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Ile Leu Glu Val Glu Leu Leu Glu Thr Tyr Met Val Ser 
            100                 105                 110         


Ala Phe Phe Ala Glu Asp Tyr Glu Ala Leu Lys Leu Ser Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Ala Leu Ile Phe Ser Asn Pro Asp Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Phe Arg Glu Lys Pro Val Arg His Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Val Asp Lys Glu Gly Asn Leu Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Lys Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg Tyr 
            180                 185                 190         


Val Glu Ala Leu Arg Glu Glu Asn Pro Gly Lys Ile Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Ala Gly Ala Gln Arg Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Arg Met Glu Pro Pro Lys Arg Lys Glu Lys 
225                 230                 235                 240 


Arg Lys Ser Arg Gln Lys Thr Leu Asp 
                245                 


<210>  58
<211>  248
<212>  PRT
<213>  Thermococcus litoralis

<400>  58

Met Lys Val Glu Ala Lys Leu Asn Pro Thr Tyr Glu Glu Ile Val Asp 
1               5                   10                  15      


Ile Phe Asn Arg Ala Leu Ser Lys Glu Ala Ile Val Asn Ile Phe Ala 
            20                  25                  30          


His Cys Arg Val Phe Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Val Gly Leu Glu Val Lys Glu Asp Lys Ile Phe Leu Arg Ser Ile Arg 
                85                  90                  95      


Arg Lys Pro Arg Glu Ile Leu Glu Val Glu Leu Leu Asn Val Tyr Leu 
            100                 105                 110         


Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Leu Ile 
    130                 135                 140                 


Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Val Asp Lys Glu Gly Asn Ile Val Ile Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Glu Ala Met Arg Glu Glu His Glu Lys Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Lys Leu Thr Pro Pro Lys Arg Gly Lys Ser 
225                 230                 235                 240 


Lys Arg Gly Arg Gln Lys Thr Leu 
                245             


<210>  59
<211>  248
<212>  PRT
<213>  Thermococcus

<400>  59

Met Lys Val Glu Ala Lys Leu Asn Pro Thr Tyr Glu Glu Ile Val Asp 
1               5                   10                  15      


Ile Phe Asn Arg Ala Leu Ser Lys Glu Ala Ile Val Asn Ile Phe Ala 
            20                  25                  30          


His Cys Arg Val Phe Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Val Gly Leu Glu Val Lys Glu Gly Arg Ile Phe Leu Arg Ser Ile Arg 
                85                  90                  95      


Arg Lys Pro Arg Glu Ile Leu Glu Val Glu Leu Leu His Val Tyr Leu 
            100                 105                 110         


Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Val Ile 
    130                 135                 140                 


Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Val Asp Lys Glu Gly Asn Ile Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Glu Ala Met Lys Glu Glu His Glu Lys Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Arg Arg Leu Thr Pro Pro Lys Arg Gly Lys Ser 
225                 230                 235                 240 


Lys Arg Gly Arg Gln Lys Thr Leu 
                245             


<210>  60
<211>  243
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  60

Glu Asn Pro Thr Val Glu Glu Val Lys Glu Leu Leu Asp Ile Ala Glu 
1               5                   10                  15      


Lys His Gly Gly Val Val Thr Ile Phe Ala Arg Cys Arg Val Tyr Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Val Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Ser Met Arg Glu Asn 
65                  70                  75                  80  


Ser Ile Ile Ser Ile Arg Arg Lys Pro His Glu Arg Leu Glu Val Glu 
                85                  90                  95      


Leu Met Glu Val Tyr Ala Val Thr Val Phe Leu Ala Glu Asp Tyr Glu 
            100                 105                 110         


Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Lys Leu Ile Phe 
        115                 120                 125             


Glu Asn Pro Asn Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg Glu 
    130                 135                 140                 


Lys Gln Ile Lys His Gly Ile Val Asp Ile Met Gly Leu Asp Lys Asp 
145                 150                 155                 160 


Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu His 
                165                 170                 175     


Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ser Leu Lys Glu Glu Tyr 
            180                 185                 190         


Gly Glu Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu Glu 
    210                 215                 220                 


Pro Pro Lys Asn Asn Asp Asn Lys Arg Glu Val Lys Gln Lys Thr Leu 
225                 230                 235                 240 


Asp Phe Phe 
            


<210>  61
<211>  247
<212>  PRT
<213>  Thermococcus thioreducens

<400>  61

Lys Val Glu Ala Val Gln Asn Pro Ser Arg Asp Glu Leu Met Arg Met 
1               5                   10                  15      


Val Asp Ser Ala Leu Ser Ala Glu Ala Met Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Lys Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Ser Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ala Phe Leu Ile His Gln 
    50                  55                  60                  


Ser Arg Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Phe Val 
65                  70                  75                  80  


Met Met Glu Glu Arg Asp Gly Ile Leu Val Leu Arg Ser Val Arg Arg 
                85                  90                  95      


Lys Pro Lys Glu Ile Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ile 
            100                 105                 110         


Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser 
        115                 120                 125             


Glu Ala Glu Met Ala Glu Met Val Phe Arg Asn Pro Glu Leu Ile Glu 
    130                 135                 140                 


Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys Gln Ile Gly His Gly Ile 
145                 150                 155                 160 


Val Asp Ile Leu Gly Arg Asp Arg Asp Gly Asn Leu Val Val Leu Glu 
                165                 170                 175     


Leu Lys Arg Arg Lys Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg 
            180                 185                 190         


Tyr Val Glu Ala Leu Lys Arg Glu His Glu Thr Val Arg Gly Ile Leu 
        195                 200                 205             


Val Ala Pro Ser Leu Thr Ala Gly Ala Lys Lys Leu Leu Glu Lys Glu 
    210                 215                 220                 


Gly Leu Glu Phe Arg Arg Val Gln Pro Pro Lys Arg Glu Lys Phe Gly 
225                 230                 235                 240 


Arg Gly Arg Gln Lys Thr Leu 
                245         


<210>  62
<211>  244
<212>  PRT
<213>  Thermococcus chitonophagus

<400>  62

Val Arg Glu Lys Pro Thr Val Glu Asp Val Lys Glu Leu Leu Glu Phe 
1               5                   10                  15      


Ala Glu Lys His Asn Gly Met Val Thr Ile Phe Ala Arg Cys Arg Val 
            20                  25                  30          


Tyr Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile 
        35                  40                  45              


Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys 
    50                  55                  60                  


Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Val Val Arg Val Glu 
65                  70                  75                  80  


Gly Asn Lys Val Ile Ser Ile Arg Arg Lys Pro Arg Glu Lys Leu Glu 
                85                  90                  95      


Val Glu Leu Ile Glu Ser Tyr Ala Ile Thr Val Phe Leu Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ser Leu Thr Gly Ser Glu Ala Glu Met Ala Lys Leu 
        115                 120                 125             


Ile Phe Glu Lys Pro Glu Val Ile Glu Glu Gly Phe Lys Pro Met Phe 
    130                 135                 140                 


Lys Glu Lys Pro Ile Lys His Gly Ile Val Asp Ile Leu Gly Ile Asp 
145                 150                 155                 160 


Arg Glu Gly Asn Val Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu 
            180                 185                 190         


Glu Tyr Gly Glu Arg Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr 
        195                 200                 205             


Glu Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Lys 
    210                 215                 220                 


Leu Glu Pro Pro Lys Arg Glu Ser Arg Lys Lys Ser Lys Gln Arg Thr 
225                 230                 235                 240 


Leu Asp Phe Phe 
                


<210>  63
<211>  245
<212>  PRT
<213>  Pyrococcus

<400>  63

Ile Lys Glu Lys Pro Thr Ala Asp Glu Ile Lys Glu Leu Leu Asp Ile 
1               5                   10                  15      


Ala Glu Lys Tyr Gly Gly Val Ile Thr Ile Phe Ala Lys Cys Lys Val 
            20                  25                  30          


Tyr Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile 
        35                  40                  45              


Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys 
    50                  55                  60                  


Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser Val Arg Ile Glu 
65                  70                  75                  80  


Gly Asn Thr Ile Ile Ser Ile Arg Arg Lys Pro Arg Glu Lys Leu Glu 
                85                  90                  95      


Val Glu Val Leu Glu Ala Tyr Ser Gly Ile Val Phe Phe Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu 
        115                 120                 125             


Ile Phe Gln Asn Pro Asp Ile Ile Glu Lys Gly Phe Lys Pro Leu Phe 
    130                 135                 140                 


Arg Glu Lys Pro Ile Lys His Gly Ile Val Asp Ile Leu Gly Val Asp 
145                 150                 155                 160 


Lys Glu Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Glu Ser Leu Lys Glu 
            180                 185                 190         


Glu Tyr Lys Arg Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr 
        195                 200                 205             


Glu Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Arg 
    210                 215                 220                 


Leu Glu Pro Pro Lys Arg Lys Asp Lys Lys Ser Arg Gly Lys Gln Lys 
225                 230                 235                 240 


Thr Leu Asp Phe Phe 
                245 


<210>  64
<211>  245
<212>  PRT
<213>  Pyrococcus

<400>  64

Ile Lys Glu Lys Pro Thr Ala Asp Glu Ile Lys Glu Leu Leu Asp Ile 
1               5                   10                  15      


Ala Glu Lys Tyr Gly Gly Val Ile Thr Ile Phe Ala Lys Cys Lys Val 
            20                  25                  30          


Tyr Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile 
        35                  40                  45              


Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Asn Lys Lys 
    50                  55                  60                  


Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser Val Arg Ile Glu 
65                  70                  75                  80  


Gly Asn Thr Ile Ile Ser Ile Arg Arg Lys Pro Arg Glu Lys Leu Glu 
                85                  90                  95      


Val Glu Val Leu Glu Ala Tyr Ser Gly Ile Val Phe Phe Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu 
        115                 120                 125             


Ile Phe Gln Asn Pro Asp Ile Ile Glu Lys Gly Phe Lys Pro Leu Phe 
    130                 135                 140                 


Arg Glu Lys Pro Ile Lys His Gly Ile Val Asp Ile Leu Gly Val Asp 
145                 150                 155                 160 


Lys Glu Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Glu Ser Leu Lys Glu 
            180                 185                 190         


Glu Tyr Lys Arg Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr 
        195                 200                 205             


Glu Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Arg 
    210                 215                 220                 


Leu Glu Pro Pro Lys Arg Lys Asp Lys Lys Ser Arg Gly Lys Gln Lys 
225                 230                 235                 240 


Thr Leu Asp Phe Phe 
                245 


<210>  65
<211>  247
<212>  PRT
<213>  Thermococcus onnurineus

<400>  65

Lys Val Glu Ala Val Thr Asn Pro Ser Arg Glu Glu Leu Leu Gly Ile 
1               5                   10                  15      


Ile Asp Ser Ala Leu Ser Lys Glu Ala Met Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Lys Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Ser Gly 
        35                  40                  45              


Asp Arg Val Ile Leu Val Lys Pro Asp Gly Ala Phe Leu Ile His Gln 
    50                  55                  60                  


Ser Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Phe Val 
65                  70                  75                  80  


Thr Val Glu Glu Arg Asp Gly Ile Ile Val Leu Arg Ser Val Arg Arg 
                85                  90                  95      


Lys Pro Lys Glu Ile Leu Glu Val Glu Leu Glu Glu Val Tyr Leu Ala 
            100                 105                 110         


Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser 
        115                 120                 125             


Glu Ala Glu Met Ala Glu Met Ile Phe Lys Asn Pro Glu Leu Ile Glu 
    130                 135                 140                 


Pro Gly Phe Arg Pro Leu Phe Arg Glu Lys Ser Ile Gly His Gly Ile 
145                 150                 155                 160 


Val Asp Ile Leu Gly Arg Asp Arg Glu Gly Asn Leu Val Val Leu Glu 
                165                 170                 175     


Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys Arg 
            180                 185                 190         


Tyr Val Glu Ala Leu Arg Ala Glu His Pro Ala Val Arg Gly Ile Leu 
        195                 200                 205             


Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Lys Leu Leu Glu Lys Glu 
    210                 215                 220                 


Gly Leu Glu Phe Arg Arg Val Gln Pro Pro Lys Arg Glu Ser Val Thr 
225                 230                 235                 240 


Lys Gly Arg Gln Thr Thr Leu 
                245         


<210>  66
<211>  242
<212>  PRT
<213>  Methanobacterium formicicum

<400>  66

Asn Pro Glu Thr Gln Arg Val Leu Glu Ile Ile Asn Glu Gly Leu Ser 
1               5                   10                  15      


Lys Arg Ala Val Ile Thr Ile Met Ala Ser Cys Arg Val Asn Tyr Asp 
            20                  25                  30          


Gly Arg Ala Val Ser Arg Leu Gly Val Gly Asp Arg Ile Ile Leu Ile 
        35                  40                  45              


Lys Ser Asp Gly Ser Phe Ile Ile His Gln Asp Arg Asn Leu Glu Pro 
    50                  55                  60                  


Val Asn Trp Gln Pro Pro Lys Thr Lys Val Thr Val Glu Thr Tyr Gln 
65                  70                  75                  80  


Gly Met Val Lys Ile Arg Gly Val Arg Arg Asn Pro Ser Glu Ser Leu 
                85                  90                  95      


Glu Val Glu Ile Leu Gln Thr His Leu Ala Ser Tyr Phe Ile Gly Glu 
            100                 105                 110         


Asp Val Glu Ser Leu Glu Leu Ala Gly Tyr Glu Ala Asn Met Gly Asp 
        115                 120                 125             


Leu Ile Phe Lys Asp Pro Glu Val Val Glu Lys Gly Phe Arg Pro Thr 
    130                 135                 140                 


Ser Arg Glu Tyr His Thr Pro Gln Gly Phe Ile Asp Ile Leu Gly Lys 
145                 150                 155                 160 


Asp Gln Asn Gly Asn Ile Thr Ile Leu Glu Leu Lys Ser Arg Lys Ala 
                165                 170                 175     


Gly Ile Asn Ala Val Lys Gln Leu Arg Arg Tyr Val Asp Cys Phe Ser 
            180                 185                 190         


Asp His Lys Glu Ala Val Arg Gly Val Leu Val Ala Pro Ser Ile Thr 
        195                 200                 205             


Asp Asp Ala Arg Gln Leu Leu Glu Glu Gln Lys Met Glu Phe Lys Ala 
    210                 215                 220                 


Leu Glu Pro Pro Arg Glu Leu Gly Thr Asp Lys Val Val Thr Leu Glu 
225                 230                 235                 240 


Asn Phe 
        


<210>  67
<211>  242
<212>  PRT
<213>  Thermococcus

<400>  67

Met Lys Val Glu Ala Lys Leu Asn Pro Ser Lys Glu Glu Ile Ile Asp 
1               5                   10                  15      


Leu Phe Ser Lys Gly Leu Ser Lys Glu Ala Ile Leu Thr Ile Phe Ala 
            20                  25                  30          


His Cys Lys Val Ser Tyr Asn Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Pro Ser Leu Ser Ala Gly Glu Asp Lys Leu Ile Leu Lys Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Asp Val Tyr Leu 
            100                 105                 110         


Phe Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Thr Leu Ala Leu Met Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Glu Leu Ile 
    130                 135                 140                 


Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys Ser Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Ile Leu Gly Lys Asp Lys Asn Gly Asn Ile Val Val Leu 
                165                 170                 175     


Glu Phe Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Glu Thr Ile Lys Glu Glu Tyr Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Arg Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Thr Pro Pro Lys Lys Glu Lys Ser 
225                 230                 235                 240 


Lys Lys 
        


<210>  68
<211>  242
<212>  PRT
<213>  Thermococcus sibiricus

<400>  68

Met Lys Val Glu Ala Lys Leu Asn Pro Ser Lys Glu Glu Ile Ile Asp 
1               5                   10                  15      


Leu Phe Ser Lys Gly Leu Ser Lys Glu Ala Ile Val Thr Ile Phe Ala 
            20                  25                  30          


His Cys Lys Val Ser Tyr Asn Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Pro Ser Leu Ser Ala Gly Glu Asp Lys Leu Ile Leu Lys Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Asp Val Tyr Leu 
            100                 105                 110         


Phe Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Thr Leu Ala Leu Met Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Glu Leu Ile 
    130                 135                 140                 


Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys Ser Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Ile Leu Gly Lys Asp Lys Asn Gly Asn Ile Val Val Leu 
                165                 170                 175     


Glu Phe Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Glu Thr Ile Lys Glu Glu Tyr Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Arg Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Thr Pro Pro Lys Lys Glu Lys Ser 
225                 230                 235                 240 


Lys Lys 
        


<210>  69
<211>  242
<212>  PRT
<213>  Thermococcus sibiricus

<400>  69

Met Lys Val Glu Val Lys Leu Asn Pro Ser Lys Glu Glu Val Ile Asp 
1               5                   10                  15      


Leu Phe Ser Arg Gly Leu Ser Thr Glu Ala Ile Val Thr Ile Phe Ala 
            20                  25                  30          


Arg Cys Asn Val Ser Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Leu 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ser 
65                  70                  75                  80  


Val Ser Leu Lys Ile Gly Glu Asp Lys Leu Ile Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Ile Leu Glu Val Gly Leu Ile Asp Val Tyr Leu 
            100                 105                 110         


Leu Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Ser Leu Ala Leu Met Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Val Phe Glu Asn Pro Glu Leu Ile 
    130                 135                 140                 


Glu Pro Gly Phe Lys Pro Ile Phe Lys Glu Lys Ser Ile Arg His Gly 
145                 150                 155                 160 


Ile Ile Asp Ile Leu Gly Lys Asp Lys Asp Gly Asn Ile Val Val Leu 
                165                 170                 175     


Glu Phe Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Glu Thr Met Arg Glu Glu Tyr Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Arg Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Thr Pro Pro Lys Lys Glu Lys Ser 
225                 230                 235                 240 


Arg Lys 
        


<210>  70
<211>  241
<212>  PRT
<213>  Thermococcus zilligii

<400>  70

Asn Pro Ser Pro Glu Glu Ile Lys Leu Leu Val Asp Ser Ala Ile Ser 
1               5                   10                  15      


Ser Glu Ala Leu Leu Thr Ile Phe Ala His Cys Arg Val Tyr Tyr Asp 
            20                  25                  30          


Gly Arg Ala Lys Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Val 
        35                  40                  45              


Lys Pro Asp Gly Ser Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro 
    50                  55                  60                  


Val Asn Trp Gln Pro Pro Gly Ser Val Val His Val Glu Leu Arg Glu 
65                  70                  75                  80  


Lys Pro Val Leu Val Ser Val Arg Arg Lys Pro Pro Glu Thr Leu Glu 
                85                  90                  95      


Val Glu Leu Glu Glu Val Tyr Leu Ile Thr Val Phe His Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu 
        115                 120                 125             


Ile Phe Glu Gln Pro Glu Val Ile Glu Pro Gly Phe Lys Pro Leu Tyr 
    130                 135                 140                 


Arg Glu Lys Pro Val Lys His Gly Ile Val Asp Val Leu Gly Val Asp 
145                 150                 155                 160 


Arg Glu Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Glu Thr Leu Lys Glu 
            180                 185                 190         


Glu His Gly Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser 
        195                 200                 205             


Gly Ala Arg Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu 
    210                 215                 220                 


Gln Pro Pro Lys Gly Gly Lys Lys Ser Arg Gly Lys Gln Leu Arg Leu 
225                 230                 235                 240 


Phe 
    


<210>  71
<211>  239
<212>  PRT
<213>  Thermococcus kodakarensis KOD1

<400>  71

Lys Val Thr Val Ile Thr Ser Pro Ser Thr Glu Glu Leu Val Ser Leu 
1               5                   10                  15      


Val Asn Ser Ala Leu Leu Glu Glu Ala Met Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Lys Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Ser Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Ser Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Arg Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Asn Pro Val Leu Val Ser Ile Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Met Val Ser 
            100                 105                 110         


Val Phe Arg Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Phe Arg Glu Lys Ala Ile Gly Thr Gly Ile Val 
145                 150                 155                 160 


Asp Val Leu Gly Arg Asp Ser Asp Gly Asn Ile Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Glu Leu His Ala Val Arg Gln Leu Lys Ser Tyr 
            180                 185                 190         


Val Glu Ile Leu Arg Glu Glu Tyr Gly Asp Lys Val Arg Gly Ile Leu 
        195                 200                 205             


Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Arg Leu Leu Glu Lys Glu 
    210                 215                 220                 


Gly Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Asp Ser Lys 
225                 230                 235                 


<210>  72
<211>  239
<212>  PRT
<213>  Thermococcus kodakarensis KOD1

<400>  72

Lys Val Thr Val Ile Thr Ser Pro Ser Thr Glu Glu Leu Val Ser Leu 
1               5                   10                  15      


Val Asn Ser Ala Leu Leu Glu Glu Ala Met Leu Thr Ile Phe Ala Arg 
            20                  25                  30          


Cys Lys Val His Tyr Asp Gly Arg Ala Lys Ser Glu Leu Gly Ser Gly 
        35                  40                  45              


Asp Arg Val Ile Ile Val Lys Pro Asp Gly Ser Phe Leu Ile His Gln 
    50                  55                  60                  


Ser Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Arg Val 
65                  70                  75                  80  


Arg Leu Glu Leu Arg Glu Asn Pro Val Leu Val Ser Ile Arg Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Leu Glu Val Glu Leu Glu Glu Val Tyr Met Val Ser 
            100                 105                 110         


Val Phe Arg Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly Ser Glu 
        115                 120                 125             


Ala Glu Met Ala Glu Leu Ile Phe Glu Asn Pro Glu Val Ile Glu Pro 
    130                 135                 140                 


Gly Phe Lys Pro Leu Phe Arg Glu Lys Ala Ile Gly Thr Gly Ile Val 
145                 150                 155                 160 


Ala Val Leu Gly Arg Asp Ser Asp Gly Asn Ile Val Val Leu Glu Leu 
                165                 170                 175     


Lys Arg Arg Arg Ala Glu Leu His Ala Val Arg Gln Leu Lys Ser Tyr 
            180                 185                 190         


Val Glu Ile Leu Arg Glu Glu Tyr Gly Asp Lys Val Arg Gly Ile Leu 
        195                 200                 205             


Val Ala Pro Ser Leu Thr Ser Gly Ala Lys Arg Leu Leu Glu Lys Glu 
    210                 215                 220                 


Gly Leu Glu Phe Arg Lys Leu Glu Pro Pro Lys Arg Asp Ser Lys 
225                 230                 235                 


<210>  73
<211>  241
<212>  PRT
<213>  Thermococcus barophilus

<400>  73

Pro Ser His Glu Glu Ile Ile Glu Ile Leu Asp Lys Ala Leu Ser Val 
1               5                   10                  15      


Glu Ala Ile Ile Thr Leu Phe Ala Tyr Cys Arg Val Phe Tyr Glu Gly 
            20                  25                  30          


Arg Ala Lys Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Ile Ile Lys 
        35                  40                  45              


Pro Asp Gly Ser Phe Leu Ile His Gln Lys Asn Lys Arg Glu Pro Val 
    50                  55                  60                  


Asn Trp Gln Pro Pro Gly Ser Val Val Ser Ile Val Leu Glu Asp Gly 
65                  70                  75                  80  


Arg Ile Met Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Thr Leu Glu 
                85                  90                  95      


Val Glu Leu Ile Lys Thr Tyr Leu Val Ser Tyr Phe Gln Ala Glu Asp 
            100                 105                 110         


Tyr Glu Glu Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Asp Leu 
        115                 120                 125             


Ile Phe Glu Asn Pro Ser Leu Ile Glu Glu Gly Phe Lys Pro Leu Phe 
    130                 135                 140                 


Lys Glu Lys Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Lys Asp 
145                 150                 155                 160 


Lys His Gly Asn Leu Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp 
                165                 170                 175     


Leu His Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ser Leu Arg Glu 
            180                 185                 190         


Glu His Lys Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ala 
        195                 200                 205             


Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Lys Leu 
    210                 215                 220                 


Asn Pro Pro Lys Arg Glu Lys Arg Lys Lys Gly Lys Gln Lys Thr Leu 
225                 230                 235                 240 


Asp 
    


<210>  74
<211>  239
<212>  PRT
<213>  Methanocaldococcus jannaschii

<400>  74

Leu Thr Asn Pro Thr Thr Lys Asp Leu Glu Asn Phe Ile Asp Met Tyr 
1               5                   10                  15      


Val Phe Lys Tyr Ile Leu Ile Leu Leu Ala Arg Cys Lys Val Phe Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Gln Leu Glu Glu Gly Asp Arg Val Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ala Phe Leu Ile His Lys Asp Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Ser Gly Ser Ser Ile Ile Trp Glu Val Glu 
65                  70                  75                  80  


Asp Asn Phe Phe Ile Leu Lys Ser Ile Arg Arg Lys Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Val Val Ile Ser Glu Val Tyr His Ala Cys Ala Phe Asn Cys 
            100                 105                 110         


Glu Asp Tyr Glu Glu Ile Asn Leu Arg Gly Ser Glu Ser Glu Met Ala 
        115                 120                 125             


Glu Met Ile Phe Arg Asn Pro Asp Leu Ile Glu Glu Gly Phe Lys Pro 
    130                 135                 140                 


Ile Ser Arg Glu Tyr Gln Ile Pro Thr Gly Ile Val Asp Ile Leu Gly 
145                 150                 155                 160 


Lys Asp Lys Glu Asn Lys Trp Val Ile Leu Glu Leu Lys Arg Arg Arg 
                165                 170                 175     


Ala Asp Leu Gln Ala Val Ser Gln Leu Lys Arg Tyr Val Glu Tyr Phe 
            180                 185                 190         


Lys Asn Lys Tyr Gly Glu Asp Lys Val Arg Gly Ile Leu Val Ser Pro 
        195                 200                 205             


Ser Leu Thr Thr Gly Ala Glu Lys Leu Leu Lys Glu Glu Asn Leu Glu 
    210                 215                 220                 


Phe Lys Arg Leu Asn Pro Pro Lys Gly Ser Lys Arg Asp Leu Lys 
225                 230                 235                 


<210>  75
<211>  239
<212>  PRT
<213>  Methanococcus jannaschii

<400>  75

Leu Thr Asn Pro Thr Thr Lys Asp Leu Glu Asn Phe Ile Asp Met Tyr 
1               5                   10                  15      


Val Phe Lys Tyr Ile Leu Ile Leu Leu Ala Arg Cys Lys Val Phe Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Gln Leu Glu Glu Gly Asp Arg Val Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ala Phe Leu Ile His Lys Asp Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Ser Gly Ser Ser Ile Ile Trp Glu Val Glu 
65                  70                  75                  80  


Asp Asn Phe Phe Ile Leu Lys Ser Ile Arg Arg Lys Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Val Val Ile Ser Glu Val Tyr His Ala Cys Ala Phe Asn Cys 
            100                 105                 110         


Glu Asp Tyr Glu Glu Ile Asn Leu Arg Gly Ser Glu Ser Glu Met Ala 
        115                 120                 125             


Glu Met Ile Phe Arg Asn Pro Asp Leu Ile Glu Glu Gly Phe Lys Pro 
    130                 135                 140                 


Ile Ser Arg Glu Tyr Gln Ile Pro Thr Gly Ile Val Asp Ile Leu Gly 
145                 150                 155                 160 


Lys Asp Lys Glu Asn Lys Trp Val Ile Leu Glu Leu Lys Arg Arg Arg 
                165                 170                 175     


Ala Asp Leu Gln Ala Val Ser Gln Leu Lys Arg Tyr Val Glu Tyr Phe 
            180                 185                 190         


Lys Asn Lys Tyr Gly Glu Asp Lys Val Arg Gly Ile Leu Val Ser Pro 
        195                 200                 205             


Ser Leu Thr Thr Gly Ala Glu Lys Leu Leu Lys Glu Glu Asn Leu Glu 
    210                 215                 220                 


Phe Lys Arg Leu Asn Pro Pro Lys Gly Ser Lys Arg Asp Leu Lys 
225                 230                 235                 


<210>  76
<211>  238
<212>  PRT
<213>  Methanocaldococcus vulcanius

<400>  76

Met Lys Val His Phe Leu His Lys Pro Asp Ile Lys Asn Leu Val Asn 
1               5                   10                  15      


Phe Ile Lys Glu His Ile Tyr Asp Ser Val Ile Ile Leu Leu Ser Arg 
            20                  25                  30          


Cys Ser Val Ile Tyr Asp Gly Arg Ala Lys Ser Thr Leu Asn Glu Gly 
        35                  40                  45              


Asp Arg Ile Ile Met Ile Lys Pro Asp Gly Ser Leu Leu Ile His Lys 
    50                  55                  60                  


Asn Lys Lys Arg Glu Pro Val Asn Trp Gln Pro Ser Gly Ser Ser Ile 
65                  70                  75                  80  


Ser Tyr Lys Ile Glu Asn Lys Gln Phe Ile Ile Arg Ser Ile Arg Lys 
                85                  90                  95      


Lys Pro Arg Glu Val Leu Glu Ile Ile Val Tyr Glu Val Tyr His Ala 
            100                 105                 110         


Cys Ala Phe Lys Cys Glu Asp Tyr Glu Glu Leu Asn Leu Thr Gly Ser 
        115                 120                 125             


Glu Gly Asp Met Val Asp Met Ile Phe Lys Asn Pro Lys Leu Ile Glu 
    130                 135                 140                 


Glu Gly Phe Lys Pro Leu Ser Lys Glu Tyr Gln Ile Pro Thr Gly Ile 
145                 150                 155                 160 


Ile Asp Ile Leu Gly Lys Asp Glu Asn Asn Asn Trp Val Ile Leu Glu 
                165                 170                 175     


Leu Lys Arg Arg Arg Ala Asp Leu Gln Ser Val Ser Gln Leu Lys Arg 
            180                 185                 190         


Tyr Val Glu Tyr Phe Lys Ser Lys Tyr Gly Glu Lys Arg Val Arg Gly 
        195                 200                 205             


Ile Leu Val Ala Pro Ser Leu Thr Thr Gly Ala Leu Asn Leu Leu Lys 
    210                 215                 220                 


Ser Glu Asn Leu Glu Phe Lys Lys Leu Thr Pro Pro Lys Lys 
225                 230                 235             


<210>  77
<211>  235
<212>  PRT
<213>  Thermococcus paralvinellae

<400>  77

Met Lys Val Glu Ala Lys Val Asp Pro Ser His Glu Glu Met Val Glu 
1               5                   10                  15      


Ile Leu Asp Lys Ala Leu Ser Thr Asp Ala Ile Ile Thr Leu Phe Ala 
            20                  25                  30          


Tyr Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Asn Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ala 
65                  70                  75                  80  


Val Ser Ile Val Leu Glu Asp Gly Lys Ile Met Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Lys Thr Tyr Leu 
            100                 105                 110         


Val Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Arg Asp Lys His Gly Asn Leu Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Ala Leu Arg Glu Glu His Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Ala Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro 
225                 230                 235 


<210>  78
<211>  235
<212>  PRT
<213>  Thermococcus paralvinellae

<400>  78

Met Lys Val Glu Ala Lys Val Asp Pro Ser His Glu Glu Met Val Glu 
1               5                   10                  15      


Ile Leu Asp Lys Ala Leu Ser Thr Asp Ala Ile Ile Thr Leu Phe Ala 
            20                  25                  30          


Tyr Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Pro 
        35                  40                  45              


Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly Ser Phe Leu Ile His 
    50                  55                  60                  


Gln Lys Asn Lys Arg Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ala 
65                  70                  75                  80  


Val Ser Ile Val Leu Glu Asp Gly Lys Ile Met Leu Arg Ser Val Arg 
                85                  90                  95      


Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Ile Lys Thr Tyr Leu 
            100                 105                 110         


Val Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu Leu Ala Leu Thr Gly 
        115                 120                 125             


Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu Asn Pro Ser Leu Ile 
    130                 135                 140                 


Glu Glu Gly Phe Lys Pro Leu Phe Lys Glu Lys Pro Ile Lys His Gly 
145                 150                 155                 160 


Ile Val Asp Val Leu Gly Arg Asp Lys His Gly Asn Leu Val Val Leu 
                165                 170                 175     


Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala Val Ser Gln Leu Lys 
            180                 185                 190         


Arg Tyr Val Asp Ala Leu Arg Glu Glu His Lys Asn Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Ile Thr Ala Gly Ala Lys Lys Leu Leu Glu Lys 
    210                 215                 220                 


Glu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro 
225                 230                 235 


<210>  79
<211>  237
<212>  PRT
<213>  Halomicrobium mukohataei

<400>  79

Glu Thr Leu Ser Asp Pro Asp Phe Asp Ala Ala Gly Asp Leu Val Glu 
1               5                   10                  15      


Arg Gly Ile Asp Ala Gly Ala Leu Val Thr Leu Phe Gly Arg Cys Arg 
            20                  25                  30          


Val Asp Tyr Asp Gly Arg Ala Thr Ser Thr Leu Gly Pro Gly Asp Arg 
        35                  40                  45              


His Val Met Leu Lys Pro Asp Gly Ala Ala Leu Val His Thr Asp Glu 
    50                  55                  60                  


Gly Gln Gln Pro Val Asn Trp Gln Pro Pro Gly Cys Glu His Ala Val 
65                  70                  75                  80  


Arg Val Val Asp Gly Glu Phe Val Val Glu Ser Glu Arg Ser Ser Pro 
                85                  90                  95      


Asp Glu Leu Leu Ser Ile Ala Phe Glu Ser Leu Ser His Val Gly Val 
            100                 105                 110         


Phe Asp Val Thr Asp Ala Thr Asp Leu Ser Leu Thr Gly Thr Glu Glu 
        115                 120                 125             


Asp Leu Arg Glu Arg Ile Leu Asp Asp Pro Asp Leu Leu Glu Pro Ala 
    130                 135                 140                 


Phe Thr Pro Leu Ala Thr Glu Arg Ser Thr Pro Ala Gly Ala Ile Asp 
145                 150                 155                 160 


Ile Tyr Gly Glu Asp Ala Asp Gly Arg Thr Val Val Val Glu Leu Lys 
                165                 170                 175     


Arg Arg Arg Val Gly Pro Asp Ala Val Gly Gln Leu Asp Arg Tyr Val 
            180                 185                 190         


Gln Ala Leu Gly Arg Asp Leu His Asp Glu Ala Glu Ile Arg Gly Leu 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Asp Arg Ala Arg Glu Leu Leu Ala Gln 
    210                 215                 220                 


Lys Gly Leu Glu Phe Val Ser Leu Ala Pro Pro Glu Glu 
225                 230                 235         


<210>  80
<211>  235
<212>  PRT
<213>  Halomicrobium katesii

<400>  80

Leu Ser Asp Pro Asp Phe Asp Ala Ala Gly Asp Leu Val Glu Arg Gly 
1               5                   10                  15      


Ile Asp Ala Gly Ala Leu Val Thr Leu Phe Gly Arg Cys Arg Val Asp 
            20                  25                  30          


Tyr Asp Gly Arg Ala Thr Ser Thr Leu Gly Pro Gly Asp Arg His Val 
        35                  40                  45              


Met Leu Lys Pro Asp Gly Ala Ala Leu Val His Thr Asp Glu Gly Gln 
    50                  55                  60                  


Gln Pro Val Asn Trp Gln Pro Pro Gly Cys Glu His Ala Val Arg Val 
65                  70                  75                  80  


Val Asp Gly Glu Phe Val Val Glu Ser Glu Arg Ser Ser Pro Asp Glu 
                85                  90                  95      


Leu Leu Ser Ile Ala Phe Glu Ser Leu Ala His Val Gly Val Phe Asp 
            100                 105                 110         


Val Thr Asp Ala Thr Asp Leu Ser Leu Thr Gly Thr Glu Ala Asp Leu 
        115                 120                 125             


Arg Glu Arg Ile Leu Asp Asp Pro Asp Leu Leu Glu Pro Ala Phe Thr 
    130                 135                 140                 


Pro Leu Ala Thr Glu Arg Ser Thr Pro Ala Gly Ala Ile Asp Ile Tyr 
145                 150                 155                 160 


Gly Glu Asp Gly Asp Gly Arg Thr Val Val Val Glu Leu Lys Arg Arg 
                165                 170                 175     


Arg Val Gly Pro Asp Ala Val Gly Gln Leu Asp Arg Tyr Val Gln Ala 
            180                 185                 190         


Leu Gly Arg Asp Leu His Asp Glu Ala Glu Ile Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Val Thr Asp Arg Ala Arg Glu Leu Leu Ala Gln Lys Gly 
    210                 215                 220                 


Leu Glu Phe Val Ser Leu Ala Pro Pro Glu Glu 
225                 230                 235 


<210>  81
<211>  235
<212>  PRT
<213>  Haloarcula japonica

<400>  81

Glu Thr Leu Thr Tyr Pro Asp Pro Ala Asp Ala Leu Asp Leu Ala Ser 
1               5                   10                  15      


Arg Asn Ala Asp Arg Gly Ala Leu Val Thr Leu Val Gly Thr Cys Thr 
            20                  25                  30          


Val Glu Tyr Glu Gly Arg Ala Ala Ser Ser Leu Gly Leu Gly Asp Arg 
        35                  40                  45              


His Val Met Leu Lys Pro Asp Gly Ala Ala Leu Val His Thr Asp Glu 
    50                  55                  60                  


Gly Gln Gln Pro Val Asn Trp Gln Pro Pro Gly Cys Glu His Ser Ile 
65                  70                  75                  80  


Ser Val Asp Asp Gly Ser Leu Val Val Arg Ser Thr Arg Ser Thr Pro 
                85                  90                  95      


Glu Glu Leu Leu Glu Val Thr Phe Glu Thr Val Ala His Ala Ala Ala 
            100                 105                 110         


Phe Asp Val Thr Asp Ser Lys Asp Leu Ala Leu Thr Gly Thr Glu Ala 
        115                 120                 125             


Asp Leu Lys Asp Arg Ile Leu Asp Glu Pro Gly Leu Val Glu Ser Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Thr Glu Arg Glu Thr Pro Ala Gly Ala Val Asp 
145                 150                 155                 160 


Ile Tyr Gly Glu Asp Ala Asp Gly Arg Thr Thr Ile Leu Glu Leu Lys 
                165                 170                 175     


Arg Arg Arg Val Gly Pro Asp Ala Val Gly Gln Leu Gly Arg Tyr Val 
            180                 185                 190         


Asp Ala Leu Glu Arg Asp Leu His Ala Asp Thr Glu Val Arg Gly Ile 
        195                 200                 205             


Leu Val Ala Pro Ser Val Thr Asp Arg Ala Arg Gln Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gly Leu Glu Phe Val Ser Leu Glu Pro Pro 
225                 230                 235 


<210>  82
<211>  226
<212>  PRT
<213>  Pyrococcus furiosus

<400>  82

Glu Asn Pro Arg Ile Glu Glu Ile Lys Glu Leu Leu Glu Val Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Leu Leu Thr Ile Phe Ala Arg Cys Thr Val Tyr Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Lys Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Lys Met Glu Gly Asn 
65                  70                  75                  80  


Ser Leu Ile Ser Ile Arg Arg Asn Pro Lys Glu Thr Leu Lys Val Asp 
                85                  90                  95      


Ile Ile Glu Ala Tyr Ala Ala Val Leu Phe Met Ala Glu Asp Tyr Glu 
            100                 105                 110         


Glu Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe 
        115                 120                 125             


Gln Asn Pro Asn Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg Glu 
    130                 135                 140                 


Lys Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Arg Glu 
145                 150                 155                 160 


Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His 
                165                 170                 175     


Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu His 
            180                 185                 190         


Gly Asn Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Glu Lys Leu Gly Leu Glu Phe Arg Lys Leu Glu 
    210                 215                 220                 


Pro Pro 
225     


<210>  83
<211>  226
<212>  PRT
<213>  Pyrococcus furiosus

<400>  83

Glu Asn Pro Arg Ile Glu Glu Ile Lys Glu Leu Leu Glu Val Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Leu Leu Thr Ile Phe Ala Arg Cys Thr Val Tyr Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Lys Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Lys Met Glu Gly Asn 
65                  70                  75                  80  


Ser Leu Ile Ser Ile Arg Arg Asn Pro Lys Glu Thr Leu Lys Val Asp 
                85                  90                  95      


Ile Ile Glu Ala Tyr Ala Ala Val Leu Phe Met Ala Glu Asp Tyr Glu 
            100                 105                 110         


Glu Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe 
        115                 120                 125             


Gln Asn Pro Asn Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg Glu 
    130                 135                 140                 


Lys Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Arg Glu 
145                 150                 155                 160 


Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His 
                165                 170                 175     


Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu His 
            180                 185                 190         


Gly Asn Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Glu Lys Leu Gly Leu Glu Phe Arg Lys Leu Glu 
    210                 215                 220                 


Pro Pro 
225     


<210>  84
<211>  226
<212>  PRT
<213>  Pyrococcus furiosus DSM 3638

<400>  84

Glu Asn Pro Arg Ile Glu Glu Ile Lys Glu Leu Leu Glu Val Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Leu Leu Thr Ile Phe Ala Arg Cys Thr Val Tyr Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Lys Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Lys Met Glu Gly Asn 
65                  70                  75                  80  


Ser Leu Ile Ser Ile Arg Arg Asn Pro Lys Glu Thr Leu Lys Val Asp 
                85                  90                  95      


Ile Ile Glu Ala Tyr Ala Ala Val Leu Phe Met Ala Glu Asp Tyr Glu 
            100                 105                 110         


Glu Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe 
        115                 120                 125             


Gln Asn Pro Asn Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg Glu 
    130                 135                 140                 


Lys Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Arg Glu 
145                 150                 155                 160 


Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His 
                165                 170                 175     


Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu His 
            180                 185                 190         


Gly Asn Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Glu Lys Leu Gly Leu Glu Phe Arg Lys Leu Glu 
    210                 215                 220                 


Pro Pro 
225     


<210>  85
<211>  226
<212>  PRT
<213>  Pyrococcus furiosus

<400>  85

Glu Asn Pro Arg Ile Glu Glu Ile Lys Glu Leu Leu Glu Val Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Leu Leu Thr Ile Phe Ala Arg Cys Thr Val Tyr Tyr 
            20                  25                  30          


Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Ile Ile 
        35                  40                  45              


Ile Lys Pro Asp Gly Ser Phe Leu Ile His Gln Lys Lys Lys Arg Glu 
    50                  55                  60                  


Pro Val Asn Trp Gln Pro Pro Gly Ser Lys Val Lys Met Glu Gly Asn 
65                  70                  75                  80  


Ser Leu Ile Ser Ile Arg Arg Asn Pro Lys Glu Thr Leu Lys Val Asp 
                85                  90                  95      


Ile Ile Glu Ala Tyr Ala Ala Val Leu Phe Met Ala Glu Asp Tyr Glu 
            100                 105                 110         


Glu Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe 
        115                 120                 125             


Gln Asn Pro Asn Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg Glu 
    130                 135                 140                 


Lys Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Arg Glu 
145                 150                 155                 160 


Gly Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His 
                165                 170                 175     


Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu His 
            180                 185                 190         


Gly Asn Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Glu Lys Leu Gly Leu Glu Phe Arg Lys Leu Glu 
    210                 215                 220                 


Pro Pro 
225     


<210>  86
<211>  232
<212>  PRT
<213>  Halostagnicola larsenii

<400>  86

Leu Glu Arg Pro Ala Val Glu Thr Ala Cys Glu Thr Val Ala Asp Gly 
1               5                   10                  15      


Ile Asp Arg Asp Ala Leu Val Thr Val Phe Gly Arg Cys Ser Val Glu 
            20                  25                  30          


Tyr Asp Gly Arg Ala Ser Ser Gln Leu Asp Ala Gly Asp Arg His Val 
        35                  40                  45              


Met Cys Lys Pro Asp Gly Thr Thr Leu Val His Thr Asp Glu Gly Gln 
    50                  55                  60                  


Gln Pro Val Asn Trp Gln Pro Pro Gly Cys Thr His Glu Val Phe Cys 
65                  70                  75                  80  


Asp Asp Gly Ala Leu Phe Leu Glu Ser His Arg Ser Thr Pro Gln Glu 
                85                  90                  95      


Arg Leu Leu Ile Gly Phe Glu Arg Val Val His Val Ser Val Phe Pro 
            100                 105                 110         


Val Ser Asp Ser Ser Glu Leu Thr Leu Val Gly Thr Glu Glu Asp Leu 
        115                 120                 125             


Arg Gln Arg Ile Leu Glu Asp Pro Gly Leu Leu Glu Pro Gly Phe Arg 
    130                 135                 140                 


Pro Leu Ala Thr Glu Arg Asp Thr Pro Ala Gly Ala Ile Asp Ile Tyr 
145                 150                 155                 160 


Gly Glu Asp Ser Val Gly Arg Ala Val Val Val Glu Leu Lys Arg Arg 
                165                 170                 175     


Arg Val Gly Pro Asp Ala Val Ser Gln Leu Arg Arg Tyr Val Asp Ala 
            180                 185                 190         


Leu Glu Arg Asp Leu His Ala Asp Ala Ser Ile Arg Gly Ile Leu Val 
        195                 200                 205             


Ala Pro Ser Val Thr Asp Arg Ala Ser Gly Leu Leu Gly Glu His Gly 
    210                 215                 220                 


Leu Glu Phe Val Ser Leu Glu Pro 
225                 230         


<210>  87
<211>  222
<212>  PRT
<213>  Thermococcus barophilus

<400>  87

Ile Thr Leu Phe Ala Tyr Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Asn Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Val Val Ser Ile Val Leu Gly Asp Gly Arg Ile Met 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Tyr Leu Val Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu 
            100                 105                 110         


Asn Pro Ser Leu Ile Glu Glu Gly Phe Lys Pro Leu Phe Lys Glu Lys 
        115                 120                 125             


Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Lys Asp Lys His Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Asp Ser Leu Arg Glu Glu His Lys 
                165                 170                 175     


Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ala Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro 
        195                 200                 205             


Lys Arg Glu Lys Arg Lys Lys Gly Lys Gln Lys Thr Leu Asp 
    210                 215                 220         


<210>  88
<211>  221
<212>  PRT
<213>  Pyrococcus

<400>  88

Phe Glu Lys Pro Ser Ile Glu Glu Val Lys Glu Leu Phe Lys Met Ala 
1               5                   10                  15      


Glu Lys His Gly Gly Val Val Thr Val Phe Ala Arg Cys Lys Val Tyr 
            20                  25                  30          


Tyr Glu Gly Arg Ala Lys Ser Glu Leu Gly Glu Gly Asp Arg Ile Ile 
        35                  40                  45              


Ile Val Lys Pro Asp Gly Thr Phe Leu Val His Gln Asn Lys Lys Arg 
    50                  55                  60                  


Glu Pro Val Asn Trp Gln Pro Pro Gly Ser Ile Val Ser Ile Glu Gly 
65                  70                  75                  80  


Asn Ser Ile Ile Ser Ile Arg Arg Arg Pro Arg Glu Lys Leu Glu Val 
                85                  90                  95      


Glu Leu Ile Asp Val Tyr Ala Val Val Val Phe Leu Ala Glu Asp Tyr 
            100                 105                 110         


Lys Glu Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Lys Leu Ile 
        115                 120                 125             


Phe Glu Asn Pro Glu Val Ile Glu Glu Gly Phe Lys Pro Met Phe Arg 
    130                 135                 140                 


Glu Lys Pro Ile Lys His Gly Ile Val Asp Ile Met Gly Val Asp Lys 
145                 150                 155                 160 


Asn Gly Asn Ile Val Ile Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu 
                165                 170                 175     


His Ala Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu 
            180                 185                 190         


Tyr Gly Glu Arg Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Glu 
        195                 200                 205             


Gly Ala Lys Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe 
    210                 215                 220     


<210>  89
<211>  221
<212>  PRT
<213>  Thermococcus cleftensis

<400>  89

Leu Thr Ile Phe Ala Arg Cys Arg Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Leu Val Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Val His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Thr Val Glu Val Arg Glu Gly Leu Val Val 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Ala Ser Leu Phe Asn Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Ile Phe Arg 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Gln Ile Gly His Gly Ile Val Asp Ile Leu Gly Lys Asp Gly Arg Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Leu Glu Arg Glu His Gly 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Val Glu Pro Pro 
        195                 200                 205             


Lys Lys Glu Lys Leu Gly Arg Gly Arg Gln Lys Thr Leu 
    210                 215                 220     


<210>  90
<211>  224
<212>  PRT
<213>  Palaeococcus pacificus

<400>  90

Ile Thr Leu Phe Ala His Cys Ser Val Phe Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ala Gly Asp Arg Val Ile Met Ile Lys Pro Asp Gly 
            20                  25                  30          


Thr Phe Leu Ile His Gln Lys Glu Lys Arg Val Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ile Val Ser Phe Gln Ile Glu Glu Gly Lys Ile Lys 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Leu Lys Val Tyr Leu Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Ala 
                85                  90                  95      


Leu Asn Leu Met Gly Ser Glu Ala Glu Met Ala Asp Leu Ile Leu Gln 
            100                 105                 110         


Asn Pro Ser Ile Ile Glu Glu Gly Phe Lys Ala Leu Gln Lys Glu Lys 
        115                 120                 125             


Pro Ile Lys His Gly Ile Ile Asp Ile Tyr Gly Val Asp Arg Asp Gly 
    130                 135                 140                 


Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Asp Ala Leu Lys Glu Glu His Gly 
                165                 170                 175     


Ser Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Glu 
            180                 185                 190         


Lys Leu Leu Lys Asp Leu Gly Leu Glu Phe Lys Lys Leu Asn Pro Pro 
        195                 200                 205             


Lys Arg Glu Lys Ala Arg Lys Gly Lys Gln Lys Thr Leu Asp Met Leu 
    210                 215                 220                 


<210>  91
<211>  222
<212>  PRT
<213>  Methanosphaera stadtmanae

<400>  91

Ile Ile Ile Leu Ala Gln Cys His Val Glu Tyr Glu Gly Arg Ala Arg 
1               5                   10                  15      


Ser Arg Leu Asp Lys Gly Asp Arg Leu Ile Leu Ile Lys Lys Asp Gly 
            20                  25                  30          


Thr Phe Thr Ile His Gln Glu Leu Asn Leu Asp Pro Val Asn Trp Gln 
        35                  40                  45              


Ala Pro Gly Cys Lys Asn Lys Val Ser Leu Lys Glu Asn Gln Ile Ile 
    50                  55                  60                  


Leu Gln Ser Ile Lys Thr Lys Pro Asp Glu Glu Ile Thr Val Tyr Leu 
65                  70                  75                  80  


Asp Thr Val Tyr Cys Ala Thr Tyr Tyr Asn Cys Val Asp Thr Lys Asn 
                85                  90                  95      


Leu Glu Ile Arg Gly Tyr Glu Lys His Met Val Asp Leu Ala Trp Glu 
            100                 105                 110         


Lys Pro Glu Leu Ile Glu Lys Gly Phe Arg Pro Thr Arg Arg Glu Tyr 
        115                 120                 125             


Gln Thr Glu Asn Gly Phe Ile Asp Leu Met Gly Thr Asp Lys Asp Glu 
    130                 135                 140                 


Lys Leu Met Ile Leu Glu Phe Lys Ser Arg Lys Ala Gly Thr Asn Ala 
145                 150                 155                 160 


Val Lys Gln Leu Lys Gly Tyr Val Glu Cys Phe Met Asp Asn Lys Glu 
                165                 170                 175     


Phe Val Arg Gly Ile Ile Val Ala Pro Asp Ile Thr Asp Asn Ala Leu 
            180                 185                 190         


Glu Leu Leu Lys Ser Leu Gln Met Glu Phe Ile Pro Leu Asn Pro Pro 
        195                 200                 205             


Lys Asp Leu Leu Thr Lys Lys Ala Ser Thr Leu Asp Ser Phe 
    210                 215                 220         


<210>  92
<211>  223
<212>  PRT
<213>  Methanocaldococcus

<400>  92

Leu Ile Leu Leu Ala Arg Cys Arg Val Phe Tyr Glu Gly Arg Ala Lys 
1               5                   10                  15      


Ser Gln Leu Glu Glu Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Thr Phe Leu Ile His Lys Asp Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Asn Ile Ile Trp Lys Val Glu Asp Asn Tyr Phe Ile 
    50                  55                  60                  


Leu Lys Ser Ile Arg Arg Lys Pro Lys Glu Glu Leu Lys Val Val Ile 
65                  70                  75                  80  


Ser Glu Val Tyr His Thr Cys Ala Phe Asn Cys Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Asn Leu Thr Gly Ser Glu Ser Glu Met Ala Glu Met Ile Phe Arg 
            100                 105                 110         


Asn Pro Asn Leu Ile Glu Glu Gly Phe Lys Pro Leu Ser Arg Glu Tyr 
        115                 120                 125             


Gln Ile Pro Thr Gly Ile Ile Asp Ile Leu Gly Lys Asp Lys Asp Glu 
    130                 135                 140                 


Arg Trp Val Ile Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu Gln Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Tyr Phe Lys Ser Lys Tyr Gly 
                165                 170                 175     


Arg Asp Arg Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Val Gly 
            180                 185                 190         


Ala Glu Arg Leu Leu Lys Glu Glu Asn Leu Glu Phe Lys Lys Leu Asn 
        195                 200                 205             


Pro Pro Lys Gly Ser Lys Lys Asp Leu Lys Gln Asn Met Lys Ser 
    210                 215                 220             


<210>  93
<211>  221
<212>  PRT
<213>  Thermococcus

<400>  93

Val Asn Ile Phe Ala His Cys Arg Val Phe Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ser Val Gly Leu Glu Ile Asn Asp Gly Lys Leu Phe 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Arg Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Leu Asn Val Tyr Leu Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu 
            100                 105                 110         


Asp Pro Ser Leu Ile Glu Ala Gly Phe Lys Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Lys Glu Gly 
    130                 135                 140                 


Asn Ile Val Ile Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Met Arg Glu Glu His Glu 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu Thr Pro Pro 
        195                 200                 205             


Lys Arg Gly Lys Ser Lys Arg Gly Arg Gln Lys Thr Leu 
    210                 215                 220     


<210>  94
<211>  215
<212>  PRT
<213>  Thermococcus sibiricus

<400>  94

Val Thr Ile Phe Ala Arg Cys Asn Val Ser Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Leu Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ser Val Ser Leu Lys Ile Gly Glu Asp Lys Leu Ile 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Gly Leu 
65                  70                  75                  80  


Ile Asp Val Tyr Leu Leu Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Ser 
                85                  90                  95      


Leu Ala Leu Met Gly Ser Glu Ala Glu Met Ala Asp Leu Val Phe Glu 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Lys Pro Ile Phe Lys Glu Lys 
        115                 120                 125             


Ser Ile Arg His Gly Ile Ile Asp Ile Leu Gly Lys Asp Lys Asp Gly 
    130                 135                 140                 


Asn Ile Val Val Leu Glu Phe Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Thr Met Arg Glu Glu Tyr Lys 
                165                 170                 175     


Asn Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Arg Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Lys Leu Thr Pro Pro 
        195                 200                 205             


Lys Lys Glu Lys Ser Arg Lys 
    210                 215 


<210>  95
<211>  221
<212>  PRT
<213>  Thermococcus piezophilus

<400>  95

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Leu Val Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Thr Val Glu Glu Arg Asp Gly Ile Ile Val 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Ala Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Ile Phe Lys 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Arg Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Ser Ile Gly His Gly Ile Val Asp Ile Leu Gly Arg Asp Arg Glu Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Leu Arg Ala Glu His Pro 
                165                 170                 175     


Ala Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Arg Val Gln Pro Pro 
        195                 200                 205             


Lys Arg Glu Ser Val Ala Lys Gly Arg Gln Thr Thr Leu 
    210                 215                 220     


<210>  96
<211>  221
<212>  PRT
<213>  Thermococcus

<400>  96

Val Asn Ile Phe Ala His Cys Arg Val Phe Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ser Val Gly Leu Glu Val Lys Glu Gly Arg Ile Phe 
    50                  55                  60                  


Leu Arg Ser Ile Arg Arg Lys Pro Arg Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Leu His Val Tyr Leu Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu 
            100                 105                 110         


Asn Pro Ser Val Ile Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys 
        115                 120                 125             


Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Lys Glu Gly 
    130                 135                 140                 


Asn Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Met Lys Glu Glu His Glu 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Arg Leu Thr Pro Pro 
        195                 200                 205             


Lys Arg Gly Lys Ser Lys Arg Gly Arg Gln Lys Thr Leu 
    210                 215                 220     


<210>  97
<211>  221
<212>  PRT
<213>  Thermococcus thioreducens

<400>  97

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Ile His Gln Ser Arg Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Met Met Glu Glu Arg Asp Gly Ile Leu Val 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Ile Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Val Phe Arg 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Gln Ile Gly His Gly Ile Val Asp Ile Leu Gly Arg Asp Arg Asp Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Leu Lys Arg Glu His Glu 
                165                 170                 175     


Thr Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ala Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Arg Val Gln Pro Pro 
        195                 200                 205             


Lys Arg Glu Lys Phe Gly Arg Gly Arg Gln Lys Thr Leu 
    210                 215                 220     


<210>  98
<211>  221
<212>  PRT
<213>  Thermococcus litoralis

<400>  98

Val Asn Ile Phe Ala His Cys Arg Val Phe Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Leu Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ser Val Gly Leu Glu Val Lys Glu Asp Lys Ile Phe 
    50                  55                  60                  


Leu Arg Ser Ile Arg Arg Lys Pro Arg Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Leu Asn Val Tyr Leu Ile Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Asp Leu Ile Phe Glu 
            100                 105                 110         


Asn Pro Ser Leu Ile Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys 
        115                 120                 125             


Pro Ile Lys His Gly Ile Val Asp Val Leu Gly Val Asp Lys Glu Gly 
    130                 135                 140                 


Asn Ile Val Ile Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Met Arg Glu Glu His Glu 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu Thr Pro Pro 
        195                 200                 205             


Lys Arg Gly Lys Ser Lys Arg Gly Arg Gln Lys Thr Leu 
    210                 215                 220     


<210>  99
<211>  221
<212>  PRT
<213>  Thermococcus onnurineus

<400>  99

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Leu Val Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Thr Val Glu Glu Arg Asp Gly Ile Ile Val 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Ala Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Ile Phe Lys 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Arg Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Ser Ile Gly His Gly Ile Val Asp Ile Leu Gly Arg Asp Arg Glu Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Leu Arg Ala Glu His Pro 
                165                 170                 175     


Ala Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Arg Val Gln Pro Pro 
        195                 200                 205             


Lys Arg Glu Ser Val Thr Lys Gly Arg Gln Thr Thr Leu 
    210                 215                 220     


<210>  100
<211>  215
<212>  PRT
<213>  Thermococcus celericrescens

<400>  100

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Thr Val Glu Glu Arg Asp Gly Ile Ile Ile 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Val Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Ile Phe Gly 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Gln Ile Gly His Gly Ile Val Asp Ile Leu Gly Arg Asp Lys Asn Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Gly Leu Ser Lys Glu His Glu 
                165                 170                 175     


Gly Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Arg Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Val Gln Pro Pro 
        195                 200                 205             


Lys Arg Glu Lys Leu Gly Lys 
    210                 215 


<210>  101
<211>  215
<212>  PRT
<213>  Thermococcus

<400>  101

Val Thr Ile Phe Ala His Cys Lys Val Phe Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Pro Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Lys Glu Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Ser Val Ser Leu Asp Val Lys Glu Asp Lys Leu Ile 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Ile Asp Val Tyr Leu Phe Ser Tyr Phe Gln Ala Glu Asp Tyr Glu Ala 
                85                  90                  95      


Leu Ala Leu Val Gly Ser Glu Ala Glu Met Ala Asp Leu Val Phe Glu 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Asp Gly Phe Lys Pro Leu Phe Lys Glu Lys 
        115                 120                 125             


Ser Ile Arg His Gly Ile Val Asp Leu Leu Gly Lys Asp Lys Asp Gly 
    130                 135                 140                 


Asn Ile Val Ile Leu Glu Phe Lys Arg Arg Arg Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Thr Met Arg Glu Glu Tyr Glu 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Arg 
            180                 185                 190         


Arg Leu Leu Glu Lys Glu Gly Leu Glu Phe Lys Lys Leu Lys Pro Pro 
        195                 200                 205             


Lys Gln Glu Lys Ser Arg Lys 
    210                 215 


<210>  102
<211>  215
<212>  PRT
<213>  Thermococcus

<400>  102

Leu Thr Ile Phe Ala Arg Cys Arg Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Ile Lys Pro Asp Gly 
            20                  25                  30          


Ala Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Phe Val Thr Ile Glu Glu Arg Asp Gly Ile Ile Ile 
    50                  55                  60                  


Leu Arg Ser Val Arg Arg Lys Pro Lys Glu Ile Leu Glu Val Glu Leu 
65                  70                  75                  80  


Glu Glu Val Tyr Leu Val Ser Leu Phe Lys Ala Glu Asp Tyr Glu Glu 
                85                  90                  95      


Leu Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Met Ile Phe Arg 
            100                 105                 110         


Asn Pro Glu Leu Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys 
        115                 120                 125             


Gln Ile Gly His Gly Ile Val Asp Ile Leu Gly Arg Asp Gly Asp Gly 
    130                 135                 140                 


Asn Leu Val Val Leu Glu Leu Lys Arg Arg Lys Ala Asp Leu His Ala 
145                 150                 155                 160 


Val Ser Gln Leu Lys Arg Tyr Val Glu Ala Leu Ser Arg Glu His Glu 
                165                 170                 175     


Ser Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Lys Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Val Gln Pro Pro 
        195                 200                 205             


Lys Arg Glu Lys Leu Gly Lys 
    210                 215 


<210>  103
<211>  213
<212>  PRT
<213>  Thermococcus kodakarensis

<400>  103

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Val Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Arg Val Arg Leu Glu Leu Arg Glu Asn Pro Val Leu 
    50                  55                  60                  


Val Ser Ile Arg Arg Lys Pro Arg Glu Thr Leu Glu Val Glu Leu Glu 
65                  70                  75                  80  


Glu Val Tyr Met Val Ser Val Phe Arg Ala Glu Asp Tyr Glu Glu Leu 
                85                  90                  95      


Ala Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe Glu Asn 
            100                 105                 110         


Pro Glu Val Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys Ala 
        115                 120                 125             


Ile Gly Thr Gly Ile Val Asp Val Leu Gly Arg Asp Ser Asp Gly Asn 
    130                 135                 140                 


Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Glu Leu His Ala Val 
145                 150                 155                 160 


Arg Gln Leu Lys Ser Tyr Val Glu Ile Leu Arg Glu Glu Tyr Gly Asp 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Arg Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu Glu Pro Pro 
        195                 200                 205             


Lys Arg Asp Ser Lys 
    210             


<210>  104
<211>  208
<212>  PRT
<213>  Thermococcus peptonophilus

<400>  104

Leu Thr Ile Phe Ala Arg Cys Lys Val His Tyr Asp Gly Arg Ala Lys 
1               5                   10                  15      


Ser Glu Leu Gly Ser Gly Asp Arg Val Ile Ile Val Lys Pro Asp Gly 
            20                  25                  30          


Ser Phe Leu Ile His Gln Ser Lys Lys Arg Glu Pro Val Asn Trp Gln 
        35                  40                  45              


Pro Pro Gly Ser Arg Val Arg Leu Glu Leu Arg Glu Asn Pro Val Leu 
    50                  55                  60                  


Val Ser Ile Arg Arg Lys Pro Lys Glu Thr Leu Glu Val Glu Leu Glu 
65                  70                  75                  80  


Glu Val Tyr Met Val Ser Val Phe Arg Ala Glu Asp Tyr Glu Glu Leu 
                85                  90                  95      


Thr Leu Thr Gly Ser Glu Ala Glu Met Ala Glu Leu Ile Phe Glu Asn 
            100                 105                 110         


Pro Glu Val Ile Glu Pro Gly Phe Lys Pro Leu Phe Arg Glu Lys Thr 
        115                 120                 125             


Ile Lys Ser Gly Ile Val Asp Ile Leu Gly Arg Asp Ser Asn Gly Asn 
    130                 135                 140                 


Ile Val Val Leu Glu Leu Lys Arg Arg Arg Ala Glu Leu His Ala Val 
145                 150                 155                 160 


Arg Gln Leu Lys Ser Tyr Val Glu Ile Leu Lys Glu Glu Tyr Gly Asp 
                165                 170                 175     


Lys Val Arg Gly Ile Leu Val Ala Pro Ser Leu Thr Ser Gly Ala Lys 
            180                 185                 190         


Arg Leu Leu Glu Lys Glu Gly Leu Glu Phe Arg Lys Leu Glu Pro Pro 
        195                 200                 205             


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic consstruct

<400>  105
cgccagggtt ttcccagtca cgac                                              24


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  106
gtcgtgactg ggaaaaccct ggcg                                              24


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  107
gtcgtgactg ggtaaaccct ggcg                                              24


<210>  108
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic constuct

<400>  108
atctgatcgg aagagcacac gtctgaactc cagtctacac tctttcccta cacgacgctc       60

ttccgatctg atcgga                                                       76


<210>  109
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  109
agagcacacg tctgaactcc agtctacact ctttccctac acgacgctct tccg             54


