                         SEQUENCE LISTING

<110>  UREkA
       Zimmer, Robert
       Goudreau, Sebastien
 
<120>  PRO-DRUG PEPTIDE WITH IMPROVED PHARMACEUTICAL PROPERTIES

<130>  1513195.131WO2

<140>  TBD
<141>  2018-06-28

<150>  US 62/526,678
<151>  2017-06-29

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
1               5                   10                  15      


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn 
            20                  25                  30          


Thr 
    


<210>  5
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Lys Pro Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
1               5                   10                  15      


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
            20                  25                  30          


Leu Asn Thr 
        35  


<210>  6
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 12-aminododecanoic acid - 12-aminododecanoic 
       acid

<400>  6

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 12-aminododecanoic acid - 12-aminododecanoic 
       acid - Lys - Lys - Lys - Lys - Lys - Lys

<400>  7

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Lys Lys Lys Lys Lys Lys

<400>  8

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 8-amino-3,6-dioxaoctanoic acid - 
       8-amino-3,6-dioxaoctanoic acid

<400>  9

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 8-amino-3,6-dioxaoctanoic acid - 
       8-amino-3,6-dioxaoctanoic acid - Lys - Lys - Lys - Lys - Lys - 
       Lys

<400>  10

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Lys Pro Lys Pro 
1               


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Lys Pro Lys Pro Lys Pro 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Lys Lys Lys Lys Lys Lys 
1               5       


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminus is amine modified

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  15

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  16
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  C-terminus is amine modified
<222>  (33)..(33)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  C-terminus is amind modified

<400>  16

Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
1               5                   10                  15      


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn 
            20                  25                  30          


Thr 
    


<210>  17
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminus us amind modified

<400>  17

Lys Pro Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
1               5                   10                  15      


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
            20                  25                  30          


Leu Asn Thr 
        35  


<210>  18
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  18

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  C-terminus is amine modified

<400>  19

Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
1               5                   10                  15      


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
            20                  25                  30          


Thr 
    


<210>  20
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminus is amine modified

<400>  20

Lys Pro Lys Pro Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
1               5                   10                  15      


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
            20                  25                  30          


Met Asn Thr 
        35  


<210>  21
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  21

Glu Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  22
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Lys Lys Lys Lys Lys Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  22

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  23
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Lys Lys Lys Lys Lys Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  23

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  24
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Lys Lys Lys Lys Lys Lys

<400>  24

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  25
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 8-amino-3,6-dioxaoctanoic acid - 
       8-amino-3,6-dioxaoctanoic acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  25

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  26
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with 8-amino-3,6-dioxaoctanoic acid - 
       8-amino-3,6-dioxaoctanoic acid - Lys - Lys - Lys - Lys - Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  26

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr 
            20                  25                  30      


<210>  27
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Pro Lys Pro Lys Pro Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminus is amine modified

<400>  27

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  28
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Functionalized with Pro Lys Pro Lys Pro Lys

<400>  28

Lys Pro His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Pro Lys Pro Lys Pro Lys 
1               5       


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Glu Pro Glu Pro 
1               


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Glu Pro Glu Pro Glu Pro 
1               5       


