                         SEQUENCE LISTING

<110>  COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN
 
<120>  Utilisation des polyktide synthases de type III de bactries 
       comme phloroglucinol synthases

<130>  B374763PCTD37152

<150>  FR1756106
<151>  2017-06-30

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Tsukamurella paurometabola

<400>  1

Met Ile Ala Pro Gln Ile Arg Leu Gly Glu Pro Asp Thr Thr Pro Leu 
1               5                   10                  15      


Pro Asp Pro Leu Trp His Gly Ala Pro Pro Ala Pro Pro Thr Thr Val 
            20                  25                  30          


Ala Val Ile Glu Ser Leu Ala Thr Gly Ser Pro Ala Gln Ala His Gly 
        35                  40                  45              


Gln Ser Val Ser Ala Glu Arg Val Ala Ala Arg Phe Ala Asp Pro Ile 
    50                  55                  60                  


Gln Ala Glu Arg Ile Arg Arg Val Tyr Ala Asn Thr Ala Val Ala Thr 
65                  70                  75                  80  


Arg His Leu Ala Ile Asp Pro Leu Ser Asp Asp Phe Ala Asp Phe Ser 
                85                  90                  95      


Ala Arg Pro Asp Thr Ile Arg Gln Arg Met Asp Leu Tyr Phe Glu His 
            100                 105                 110         


Ala Ala Pro Leu Ala Ile Glu Thr Ala Arg Arg Ala Leu Gly Ala Val 
        115                 120                 125             


Asp Ala Thr Glu Val Gly Gln Leu Ile Phe Val Thr Ser Thr Gly Phe 
    130                 135                 140                 


Leu Ala Pro Gly Val Asp Val Ala Val Thr Arg Ser Leu Gly Leu Pro 
145                 150                 155                 160 


Ala Ser Thr Ser Arg Val Val Ile Asn Phe Met Gly Cys Ala Ala Ala 
                165                 170                 175     


Met Asn Ala Leu Arg Val Ala Ser Asp Phe Val Arg Ala His Pro Asp 
            180                 185                 190         


Arg Lys Ser Leu Leu Val Cys Leu Glu Leu Ser Ser Val Asn Ala Val 
        195                 200                 205             


Phe Ala Gly Asp Pro Asn Asp Val Val Ile Ser Ser Leu Phe Ala Asp 
    210                 215                 220                 


Gly Cys Gly Ala Ala Leu Ile Gly Ala Ser Glu Val Gly His Pro Leu 
225                 230                 235                 240 


Pro Ala Gly His Ile Val Val Arg Asp Thr Phe Ala His Leu Leu Asp 
                245                 250                 255     


Asp Ala Glu Asp Gly Ile Val Leu Gly Val Asn Ala Asn Gly Ile Thr 
            260                 265                 270         


Cys Glu Leu Ala His Ser Leu Pro Arg Tyr Ile Leu Asp Gly Val Ser 
        275                 280                 285             


Pro Val Ile Asp Gly Val Leu Ala Arg Asn Gly Leu Gly Arg Glu Asp 
    290                 295                 300                 


Val Ala His Trp Ala Ile His Pro Gly Gly Pro Lys Ile Ile Glu Ser 
305                 310                 315                 320 


Ala Ser Ala Ala Leu Gly Leu Pro Arg Ser Ala Ser Gln Thr Ser Trp 
                325                 330                 335     


Ala Val Leu Ala Glu His Gly Asn Met Leu Ser Val Ser Leu Leu Phe 
            340                 345                 350         


Val Leu Glu Arg Leu Leu Gly Ala Arg Ala Ala Gly Gly Thr Gln Glu 
        355                 360                 365             


Thr Gly Leu Ala Phe Ser Phe Ala Pro Gly Val Thr Val Glu Gly Phe 
    370                 375                 380                 


Leu Phe Asp Val Val Gly Gly Pro Ser 
385                 390             


<210>  2
<211>  412
<212>  PRT
<213>  Tsukamurella tyrosinosolvens

<400>  2

Met Thr Met Asn Ala Gly Ser Gln Gly Ala Pro Ala Leu Asp Val Pro 
1               5                   10                  15      


Ala Pro Val Leu Pro Ala Pro Gly Thr Trp Leu Gly Ala Pro Pro Ala 
            20                  25                  30          


Pro Pro Thr Ser Val Ala Val Ile Glu Ser Leu Ala Thr Gly Ser Pro 
        35                  40                  45              


Ala Gln Thr Tyr Gly Gln Ala Glu Ser Ala Asp Arg Val Ala Ala Arg 
    50                  55                  60                  


Phe Asp Asp Pro Arg Gln Ala Glu Arg Ile Arg Arg Val Tyr Ala Lys 
65                  70                  75                  80  


Thr Arg Val Asp Glu Arg His Leu Ala Ile Asp Pro Leu Thr Pro Glu 
                85                  90                  95      


Phe Ala Glu Phe Ser Thr Arg Pro Asp Thr Val Arg Glu Arg Met Asp 
            100                 105                 110         


Leu Phe Tyr Glu His Ala Ala Pro Leu Ala Val Asp Thr Ala Arg Arg 
        115                 120                 125             


Ala Leu Gly Val Gly Thr Glu His Glu Phe Asp Pro Ala Asp Val Gly 
    130                 135                 140                 


Gln Leu Val Phe Val Thr Ser Thr Gly Phe Leu Ala Pro Gly Val Asp 
145                 150                 155                 160 


Val Ala Val Ile Arg Ala Leu Gly Leu Ala Pro Gln Thr Ser Arg Val 
                165                 170                 175     


Val Ile Asn Phe Met Gly Cys Ala Ala Ala Met Asn Ala Leu Arg Val 
            180                 185                 190         


Ser Thr Asp Tyr Val Arg Ala His Pro Asp Arg Lys Ser Leu Met Ile 
        195                 200                 205             


Cys Leu Glu Leu Ser Ser Val Asn Ala Val Phe Ser Gly Asp Pro Asn 
    210                 215                 220                 


Asp Val Val Ile Ser Ser Leu Phe Ala Asp Gly Cys Gly Ala Ala Val 
225                 230                 235                 240 


Ile Gly Ala Ser Glu Val Gly His Pro Leu Pro Gly Gly Arg Ile Val 
                245                 250                 255     


Val Arg Asp Thr Phe Thr His Leu Leu Asp Gly Ala Glu Asp Gly Ile 
            260                 265                 270         


Val Leu Gly Val Asn Ala Asn Gly Ile Thr Cys Glu Leu Ala Glu Ser 
        275                 280                 285             


Leu Pro Gln Tyr Ile Val Asp Gly Val Ala Pro Val Ile Asp Glu Val 
    290                 295                 300                 


Leu Gly Arg Asn Asp Leu Gly Arg Glu Ala Val Ala His Trp Ala Ile 
305                 310                 315                 320 


His Pro Gly Gly Pro Lys Ile Ile Glu Ser Ala Ala Thr Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Glu Ala Ser Arg Thr Ser Trp Asp Val Leu Ala Glu His 
            340                 345                 350         


Gly Asn Met Leu Ser Val Ser Leu Leu Phe Val Leu Glu Arg Leu Leu 
        355                 360                 365             


Ala Gln Val Ala Asp Gly Ala Ala Thr Gln Pro Asp Gly Ala Pro Thr 
    370                 375                 380                 


Thr Gly Met Ala Phe Ser Phe Ala Pro Gly Val Thr Val Glu Gly Phe 
385                 390                 395                 400 


Leu Phe Asp Val Val Thr Gly Asp Gln Pro Gly Glu 
                405                 410         


<210>  3
<211>  387
<212>  PRT
<213>  Tsukamurella pseudospumae

<400>  3

Met Ala Ala Pro Glu Leu Pro Gly Thr Ser Val Trp Arg Gly Ala Pro 
1               5                   10                  15      


Pro Ala Pro Pro Thr Ser Val Ala Val Ile Glu Ser Leu Ala Thr Gly 
            20                  25                  30          


Ser Pro Ser Gln Ala Tyr Asp Gln Ala Glu Ser Ala Asp Arg Val Ala 
        35                  40                  45              


Ser Arg Phe Asp Asp Pro Arg Gln Ala Glu Arg Ile Arg Arg Val Tyr 
    50                  55                  60                  


Ala Lys Thr Arg Val Ala Glu Arg His Leu Ala Ile Asp Pro Leu Thr 
65                  70                  75                  80  


Pro Glu Phe Ala Ala Phe Ser Thr Arg Pro Asp Thr Ile Arg Glu Arg 
                85                  90                  95      


Met Asp Leu Phe Phe Glu His Ala Ala Pro Leu Ala Ile Asp Thr Ala 
            100                 105                 110         


Arg Arg Ala Leu Gly Thr Val Asp Pro Ala Asp Val Gly Gln Leu Val 
        115                 120                 125             


Phe Val Thr Ser Thr Gly Phe Leu Ala Pro Gly Val Asp Val Ala Val 
    130                 135                 140                 


Ile Arg Ala Leu Gly Leu Ser Pro Gly Thr Ser Arg Val Val Ile Asn 
145                 150                 155                 160 


Phe Met Gly Cys Ala Ala Ala Met Asn Ala Leu Arg Val Ser Thr Asp 
                165                 170                 175     


Tyr Val Arg Ala His Pro Asp Arg Lys Ser Leu Met Ile Cys Leu Glu 
            180                 185                 190         


Leu Ser Ser Val Asn Ala Val Phe Ser Gly Asp Pro Asn Asp Val Val 
        195                 200                 205             


Ile Ser Ser Leu Phe Ala Asp Gly Cys Gly Ala Ala Leu Ile Gly Ala 
    210                 215                 220                 


Ser Glu Val Gly His Pro Leu Pro Ala Gly Asn Ile Val Val Arg Asp 
225                 230                 235                 240 


Thr Phe Ser His Leu Leu Asp Gly Ala Glu Asp Gly Ile Val Leu Gly 
                245                 250                 255     


Val Asn Ala Asp Gly Ile Thr Cys Glu Leu Ala Glu Ser Leu Pro Gln 
            260                 265                 270         


Tyr Ile Val Asp Gly Val Ala Pro Val Val Asp Gly Val Leu Arg Arg 
        275                 280                 285             


Asn Gly Leu Asp Arg Asp Ala Val Ala His Trp Ala Ile His Pro Gly 
    290                 295                 300                 


Gly Pro Lys Ile Ile Glu Ser Ala Ser Thr Ala Leu Gly Leu Pro Asp 
305                 310                 315                 320 


Glu Ala Ser Arg Leu Ser Trp Asp Val Leu Ala Gly His Gly Asn Met 
                325                 330                 335     


Leu Ser Val Ser Leu Leu Phe Val Leu Glu Arg Leu Leu Ala Gln Val 
            340                 345                 350         


Ala Ser Asp Gly Ala Asp Gly Ala Pro Ser Thr Gly Met Ala Phe Ser 
        355                 360                 365             


Phe Ala Pro Gly Val Thr Val Glu Gly Phe Leu Phe Asp Val Val Thr 
    370                 375                 380                 


Thr Gly Glu 
385         


<210>  4
<211>  390
<212>  PRT
<213>  Tsukamurella pulmonis

<400>  4

Met Asn Thr Thr Glu Gln Gln Ser Val Leu Pro Gln Gln Ala Trp Leu 
1               5                   10                  15      


Gly Ala Pro Pro Ala Pro Pro Thr Ser Val Ala Val Ile Glu Ser Leu 
            20                  25                  30          


Ala Thr Ser Ser Pro Thr Gln Thr Tyr Gly Gln Ala Glu Ser Ala Asp 
        35                  40                  45              


Arg Val Ala Ala Arg Phe Asp Asp Pro Arg Gln Ala Glu Arg Ile Arg 
    50                  55                  60                  


Arg Val Tyr Ala Lys Thr Arg Val Thr Glu Arg His Leu Ala Ile Asp 
65                  70                  75                  80  


Pro Leu Thr Pro Glu Phe Ala Glu Phe Ser Ala Arg Pro Asp Thr Val 
                85                  90                  95      


Arg Glu Arg Met Asp Leu Phe Phe Glu His Ala Ala Pro Leu Ala Ile 
            100                 105                 110         


Glu Thr Ala Arg Arg Ala Leu Gly Asp Asn Ala Ala Thr Asp Ile Gly 
        115                 120                 125             


Gln Leu Val Phe Val Thr Ser Thr Gly Phe Leu Ala Pro Gly Val Asp 
    130                 135                 140                 


Val Ala Val Ile Arg Ala Leu Gly Leu Ala Pro Gln Thr Ser Arg Val 
145                 150                 155                 160 


Val Ile Asn Phe Met Gly Cys Ala Ala Ala Met Asn Ala Leu Arg Val 
                165                 170                 175     


Ser Thr Asp Tyr Val Arg Ala Gln Pro Asp Arg Lys Ser Leu Met Ile 
            180                 185                 190         


Cys Leu Glu Leu Ser Ser Val Asn Ala Val Phe Ser Gly Asp Pro Asn 
        195                 200                 205             


Asp Val Val Ile Ser Ser Leu Phe Ala Asp Gly Cys Gly Ala Ala Val 
    210                 215                 220                 


Ile Gly Ala Ser Glu Val Gly His Pro Leu Pro Ser Gly Gln Ile Val 
225                 230                 235                 240 


Val Arg Asp Thr Phe Thr His Leu Leu Asp Gly Ala Glu Asp Gly Ile 
                245                 250                 255     


Val Leu Gly Val Asn Ala Asn Gly Ile Thr Cys Glu Leu Ala Glu Ser 
            260                 265                 270         


Leu Pro Gln Tyr Ile Val Asn Gly Val Ala Pro Val Val Asp Ala Val 
        275                 280                 285             


Leu Asp Arg Asn Gly Leu Gly Arg Glu Ala Val Ala His Trp Ala Ile 
    290                 295                 300                 


His Pro Gly Gly Pro Lys Ile Ile Glu Ser Ala Ala Ala Ala Leu Gly 
305                 310                 315                 320 


Leu Pro Asp Asp Ala Ser Arg Leu Ser Trp Asp Val Leu Ala Glu His 
                325                 330                 335     


Gly Asn Met Leu Ser Val Ser Leu Leu Phe Val Leu Glu Arg Leu Arg 
            340                 345                 350         


Ala Gln Val Ala Ser Asp Gly Ala Asp Gly Ala Pro Ser Thr Gly Met 
        355                 360                 365             


Ala Phe Ser Phe Ala Pro Gly Val Thr Val Glu Gly Phe Leu Phe Asp 
    370                 375                 380                 


Val Val Thr Thr Gly Glu 
385                 390 


<210>  5
<211>  397
<212>  PRT
<213>  Tsukamurella sp. 1534

<400>  5

Met Asn Ile Gln Asp Arg Ser Thr Val Ala Pro Asp Ser Pro Ala Leu 
1               5                   10                  15      


Gly Phe Pro Pro Ala Pro Pro Thr Ser Val Ala Val Ile Glu Ser Leu 
            20                  25                  30          


Ala Thr Gly Ser Pro Ser Gly Val His Ala Gln Ala Glu Ser Ala Asp 
        35                  40                  45              


Arg Val Ala Ser Arg Phe Asp Asp Pro Ala Gln Ala Glu Arg Ile Arg 
    50                  55                  60                  


Arg Val Tyr Thr Lys Thr Arg Val Ala Arg Arg His Leu Ala Ile Asp 
65                  70                  75                  80  


Pro Leu Asp Glu Asp Phe Ala Ala Phe Ser Ala Arg Pro Asp Thr Ile 
                85                  90                  95      


Arg Glu Arg Met Asp Leu Phe Ala Glu His Ala Ser Pro Leu Ala Val 
            100                 105                 110         


Asp Thr Ala Arg Arg Ala Leu Gly Ala Val Asp Pro Ala Asp Val Gly 
        115                 120                 125             


Gln Leu Val Phe Val Thr Ser Thr Gly Phe Leu Ala Pro Gly Val Asp 
    130                 135                 140                 


Val Ala Ile Val Arg Ala Leu Gly Leu Pro Ala Thr Thr Ser Arg Val 
145                 150                 155                 160 


Ile Val Asn Phe Met Gly Cys Ala Ala Ala Met Asn Ala Leu Arg Val 
                165                 170                 175     


Ala Ser Asp Phe Val Arg Ala His Pro Asp Arg Lys Ser Leu Met Val 
            180                 185                 190         


Cys Leu Glu Leu Ser Ser Val Asn Ala Val Phe Ser Gly Asp Pro Asn 
        195                 200                 205             


Asp Val Val Ile Ser Ser Leu Phe Ala Asp Gly Cys Gly Ala Ala Val 
    210                 215                 220                 


Ile Gly Ala Ser Glu Val Gly His Pro Leu Pro Gly Gly Ser Ile Val 
225                 230                 235                 240 


Val Arg Asp Thr Phe Ala His Leu Leu Asp Gly Ala Glu Asp Gly Ile 
                245                 250                 255     


Val Leu Gly Val Asn Ala Asn Gly Ile Thr Cys Glu Leu Ala Glu Ser 
            260                 265                 270         


Leu Pro Arg Tyr Ile Val Asp Gly Val Arg Pro Val Ile Asp Gly Val 
        275                 280                 285             


Leu Ala Arg Asn Gly Leu Gly His Ala Asp Val Ala His Trp Ala Ile 
    290                 295                 300                 


His Pro Gly Gly Pro Lys Ile Ile Glu Ser Ala Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Leu Pro Ala Ala Ala Ser Ala Thr Ser Trp Gln Val Leu Ala Glu His 
                325                 330                 335     


Gly Asn Met Leu Ser Val Ser Leu Leu Phe Val Leu Glu Arg Met Leu 
            340                 345                 350         


Ser Gly Leu Pro Asp Gly Ala Pro Ser Thr Gly Met Ala Phe Ser Phe 
        355                 360                 365             


Ala Pro Gly Val Thr Val Glu Gly Phe Leu Phe Asp Ile Val Arg Asp 
    370                 375                 380                 


Gly Ala Pro Arg Pro Gly Ala Leu Gly Gly Arg Pro Ala 
385                 390                 395         


<210>  6
<211>  400
<212>  PRT
<213>  Nocardia farcinica

<400>  6

Met Ser Ile Thr Val Asp Glu Gly Gly Ala Arg Pro Ala Thr Glu Pro 
1               5                   10                  15      


Arg Gln Arg Ile His Pro Asp Leu Gly His Ala His Thr Pro Met Pro 
            20                  25                  30          


Pro Ala Pro Pro Val Thr Ile Gly Val Val Glu Gly Ile Ala Thr Gly 
        35                  40                  45              


Ser Pro Ala Gln Ile Val Asp Gln Ala Glu Ala Ala Glu Arg Val Ala 
    50                  55                  60                  


Ala Leu Phe Thr Asp Pro Ala Gln Arg Ala Arg Ile Ala Arg Val Tyr 
65                  70                  75                  80  


Glu Lys Thr Arg Ile Glu Thr Arg Arg Met Ala Val Asp Pro Thr Ala 
                85                  90                  95      


Pro Glu Phe Arg Ser Phe Ser Arg Gln Pro Gly Thr Leu Arg Glu Arg 
            100                 105                 110         


Met Asn Leu Phe Tyr Arg His Ala Ala Pro Leu Ala Val Asp Val Ala 
        115                 120                 125             


Gly Arg Ala Leu Ala Asp Ser Gly Ala Ala Ala Ala Asp Ile Gly Leu 
    130                 135                 140                 


Leu Val Phe Val Thr Ser Thr Gly Phe Ile Ala Pro Gly Val Asp Val 
145                 150                 155                 160 


Ala Val Leu Arg Glu Leu Gly Leu Val Pro Thr Val Gly Arg Val Val 
                165                 170                 175     


Val Asn Phe Met Gly Cys Ala Ala Ala Met Asn Gly Ile Arg Thr Gly 
            180                 185                 190         


Val Asp Tyr Val Arg Ala His Pro Asp Lys Lys Ala Leu Val Val Cys 
        195                 200                 205             


Leu Glu Leu Ser Ser Val Asn Ala Val Phe Ala Asp Asp Val Asn Asp 
    210                 215                 220                 


Val Ile Ile His Ser Leu Phe Gly Asp Gly Cys Gly Ala Val Val Leu 
225                 230                 235                 240 


Gly Ala Ser Gln Ala Arg Gln Pro Leu Ala Pro Gly Arg Val Val Val 
                245                 250                 255     


Arg Asp Ser Phe Ser His Leu Phe Asp Ala Ala Glu Asp Gly Ile Val 
            260                 265                 270         


Leu Gly Val Asp His Asn Gly Ile Thr Cys Glu Leu Ser Glu Asn Leu 
        275                 280                 285             


Pro Arg Tyr Ile Tyr Arg Gly Val Asp Pro Val Val Arg Glu Val Leu 
    290                 295                 300                 


Ala Arg Asn Gly Leu Arg Lys Ser Asp Ile Asp Leu Trp Ala Ile His 
305                 310                 315                 320 


Pro Gly Gly Pro Lys Ile Ile Glu Glu Ser Val Arg Ser Leu Gly Leu 
                325                 330                 335     


Ser Pro Glu Gln Ala Ala Pro Ser Trp Asp Val Leu Ala Arg His Gly 
            340                 345                 350         


Asn Met Leu Ser Val Ser Leu Ile Phe Val Leu Glu Gln Met Ile Ala 
        355                 360                 365             


Gln Ser Ala Thr Ala Glu Pro Ile Ser Thr Gly Val Ala Phe Ser Phe 
    370                 375                 380                 


Ala Pro Gly Val Thr Leu Glu Gly Leu Ile Phe Asp Ile Ile Arg Arg 
385                 390                 395                 400 


<210>  7
<211>  393
<212>  PRT
<213>  Mycobacterium marinum

<400>  7

Met Ser Thr Ala Ala Glu Gly Gly Ala Ile Arg Arg Ala Gly His Glu 
1               5                   10                  15      


Pro Arg Tyr Asp Leu Ala Gln Leu Pro Pro Ala Pro Pro Thr Thr Val 
            20                  25                  30          


Ala Val Ile Glu Gly Met Ala Thr Gly Ala Pro Gln Arg Val Val Ala 
        35                  40                  45              


Gln Ala Asp Ala Ala Ala Arg Val Ser Glu Leu Phe Val Asp Pro Gln 
    50                  55                  60                  


Gln Arg Glu Arg Ile Ser Arg Ile Tyr Asp Lys Thr Arg Ile Asp Thr 
65                  70                  75                  80  


Arg Arg Met Ala Val Asp Pro Leu Asp Asp Glu Phe Asp Glu Phe Arg 
                85                  90                  95      


Arg Glu Pro Ala Thr Ile Arg Asp Arg Met Asn Leu Phe Tyr Gln His 
            100                 105                 110         


Ala Val Pro Leu Ala Val Asp Val Ala Ala Arg Ala Leu Asp Gly Leu 
        115                 120                 125             


Pro Tyr Ala Pro Asp Glu Ile Gly Gln Leu Val Phe Val Thr Ser Thr 
    130                 135                 140                 


Gly Phe Ile Ala Pro Gly Val Asp Val Glu Ile Val Lys Gln Leu Gly 
145                 150                 155                 160 


Leu Pro Arg Ser Ile Ser Arg Val Val Val Asn Phe Met Gly Cys Ala 
                165                 170                 175     


Ala Ala Met Asn Ala Ile Arg Thr Ala Thr Asn Tyr Val Arg Ala His 
            180                 185                 190         


Pro Ser Met Lys Ala Leu Val Val Cys Ile Glu Leu Ser Ser Val Asn 
        195                 200                 205             


Ala Val Phe Ala Asp Asp Ile Asn Asp Val Val Ile His Ser Leu Phe 
    210                 215                 220                 


Gly Asp Gly Cys Gly Ala Leu Val Ile Gly Ala Ser Gln Val Gln Gln 
225                 230                 235                 240 


Pro Leu Pro Ala Gly Asn Val Val Ile Arg Ser Ser Phe Ser Gln Leu 
                245                 250                 255     


Leu Asp Asp Ser Glu Asp Gly Ile Val Leu Gly Val Asn His Asp Gly 
            260                 265                 270         


Ile Thr Cys Glu Leu Ser Glu Asn Leu Pro Ser Tyr Ile Tyr Arg Ser 
        275                 280                 285             


Val Asp Pro Val Val Ala Glu Met Leu Arg Asp Asn Gly Leu Ser Lys 
    290                 295                 300                 


Ala Asp Ile Asp Leu Trp Ala Ile His Pro Gly Gly Pro Lys Ile Ile 
305                 310                 315                 320 


Glu Gln Ser Ala Arg Ser Leu Gly Ile Pro Val Gly Arg Ala Val Gln 
                325                 330                 335     


Ser Trp Asp Val Leu Ala Gln Phe Gly Asn Met Leu Ser Val Ser Leu 
            340                 345                 350         


Ile Phe Val Leu Glu Met Met Val Ala Gln Ala Glu Ser Asp Lys Pro 
        355                 360                 365             


Ile Ser Thr Gly Val Ala Phe Ala Phe Ala Pro Gly Val Thr Val Glu 
    370                 375                 380                 


Gly Met Leu Phe Asp Ile Ile Arg Arg 
385                 390             


<210>  8
<211>  395
<212>  PRT
<213>  Mycobacterium kansasii

<400>  8

Met Ser Ser Ala Ala Asp Gly Gly Ala Pro Val Ala Asp Val Pro Gly 
1               5                   10                  15      


Tyr Glu Pro His Tyr Asp Leu Ala Gln Leu Pro Pro Ala Pro Pro Thr 
            20                  25                  30          


Thr Val Ala Val Ile Glu Gly Met Ala Thr Gly Val Pro Gln Arg Val 
        35                  40                  45              


Val Arg Gln Ser Asp Ala Ala Ala Arg Val Ala Gln Met Phe Val Asp 
    50                  55                  60                  


Pro Gln Gln Arg Glu Arg Val Ser Arg Val Tyr Ala Lys Thr Arg Ile 
65                  70                  75                  80  


Asp Thr Arg Arg Met Ala Val Asn Pro Leu Asp Ala Glu Phe Asp Ala 
                85                  90                  95      


Phe Arg Arg Glu Pro Ala Thr Ile Arg Asp Arg Met Ser Leu Phe Tyr 
            100                 105                 110         


Arg His Ala Val Pro Leu Ala Val Glu Val Thr Arg Arg Ala Leu Ala 
        115                 120                 125             


Gly Leu Ser Tyr Gly Ala Asp Glu Ile Gly Leu Leu Val Phe Val Thr 
    130                 135                 140                 


Ser Thr Gly Phe Val Ala Pro Gly Val Asp Val Ala Ile Val Lys Glu 
145                 150                 155                 160 


Leu Gly Leu Ser Arg Ala Ile Ser Arg Val Val Val Asn Phe Met Gly 
                165                 170                 175     


Cys Ala Ala Ala Met Asn Ala Ile Arg Thr Ala Thr Asn Tyr Val Arg 
            180                 185                 190         


Ala His Pro Ala Met Lys Ala Leu Val Val Cys Ile Glu Leu Cys Ser 
        195                 200                 205             


Val Asn Ala Val Phe Ala Asp Asn Val Lys Asp Val Val Ile His Ser 
    210                 215                 220                 


Leu Phe Gly Asp Gly Cys Ala Ala Leu Val Ile Gly Ala Ser Gln Val 
225                 230                 235                 240 


Gln Gln Gln Leu Pro Ala Gly Ser Val Val Ile Arg Ser Asn Phe Ser 
                245                 250                 255     


Gln Leu Leu Asp Asp Ala Glu Asp Gly Ile Val Leu Gly Val Asn His 
            260                 265                 270         


Asp Gly Ile Thr Cys Glu Leu Ser Glu Asn Leu Pro Asp Tyr Ile Tyr 
        275                 280                 285             


Arg Gly Val Ala Pro Val Val Ala Asn Val Leu Tyr Asp Asn Gly Leu 
    290                 295                 300                 


Gln Gln Ser Asp Ile Asp Leu Trp Ala Ile His Pro Gly Gly Pro Lys 
305                 310                 315                 320 


Ile Ile Glu Gln Ser Val Arg Ser Leu Gly Ile Gly Val Glu Cys Ala 
                325                 330                 335     


Ala Pro Ser Trp Asp Val Leu Ala Arg Tyr Gly Asn Met Leu Ser Val 
            340                 345                 350         


Ser Leu Ile Phe Val Leu Glu Met Met Val Gln Gln Ala Glu Ser Glu 
        355                 360                 365             


Lys Pro Leu Ser Thr Gly Val Ala Phe Ala Phe Ala Pro Gly Val Thr 
    370                 375                 380                 


Val Glu Gly Met Leu Phe Asp Ile Val Arg Arg 
385                 390                 395 


<210>  9
<211>  334
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  9

Met Asn Val Ser Ala Glu Ser Gly Ala Pro Arg Arg Ala Gly Gln Arg 
1               5                   10                  15      


His Glu Val Gly Leu Ala Gln Leu Pro Pro Ala Pro Pro Thr Thr Val 
            20                  25                  30          


Ala Val Ile Glu Gly Leu Ala Thr Gly Thr Pro Arg Arg Val Val Asn 
        35                  40                  45              


Gln Ser Asp Ala Ala Asp Arg Val Ala Glu Leu Phe Leu Asp Pro Gly 
    50                  55                  60                  


Gln Arg Glu Arg Ile Pro Arg Val Tyr Gln Lys Ser Arg Ile Thr Thr 
65                  70                  75                  80  


Arg Arg Met Ala Val Asp Pro Leu Asp Ala Lys Phe Asp Val Phe Arg 
                85                  90                  95      


Arg Glu Pro Ala Thr Ile Arg Asp Arg Met His Leu Phe Tyr Glu His 
            100                 105                 110         


Ala Val Pro Leu Ala Val Asp Val Ser Lys Arg Ala Leu Ala Gly Leu 
        115                 120                 125             


Pro Tyr Arg Ala Ala Glu Ile Gly Leu Leu Val Leu Ala Thr Ser Thr 
    130                 135                 140                 


Gly Phe Ile Ala Pro Gly Val Asp Val Ala Ile Val Lys Glu Leu Gly 
145                 150                 155                 160 


Leu Ser Pro Ser Phe Gly Asp Gly Cys Ala Ala Leu Val Ile Gly Ala 
                165                 170                 175     


Ser Gln Val Gln Glu Lys Leu Glu Pro Gly Lys Val Val Val Arg Ser 
            180                 185                 190         


Ser Phe Ser Gln Leu Leu Asp Asn Thr Glu Asp Gly Ile Val Leu Gly 
        195                 200                 205             


Val Asn His Asn Gly Ile Thr Cys Glu Leu Ser Glu Asn Leu Pro Gly 
    210                 215                 220                 


Tyr Ile Phe Ser Gly Val Ala Pro Val Val Thr Glu Met Leu Trp Asp 
225                 230                 235                 240 


Asn Gly Leu Gln Ile Ser Asp Ile Asp Leu Trp Ala Ile His Pro Gly 
                245                 250                 255     


Gly Pro Lys Ile Ile Glu Gln Ser Val Arg Ser Leu Gly Ile Ser Ala 
            260                 265                 270         


Glu Leu Ala Ala Gln Ser Trp Asp Val Leu Ala Arg Phe Gly Asn Met 
        275                 280                 285             


Leu Ser Val Ser Leu Ile Phe Val Leu Glu Thr Met Val Gln Gln Ala 
    290                 295                 300                 


Glu Ser Ala Lys Ala Ile Ser Thr Gly Val Ala Phe Ala Phe Gly Pro 
305                 310                 315                 320 


Gly Val Thr Val Glu Gly Met Leu Phe Asp Ile Ile Arg Arg 
                325                 330                 


<210>  10
<211>  370
<212>  PRT
<213>  Gordonia hydrophobica

<400>  10

Met Pro Ala Pro Val Thr Thr Val Ala Val Ile Glu Ala Val Ala Thr 
1               5                   10                  15      


Gly Ala Pro Ala Thr Val His Pro Gln Thr Arg Ala Ala Glu Gln Val 
            20                  25                  30          


Ala Glu Leu Tyr Asp Asp Pro Ala Leu Gln Glu Arg Ile Arg Arg Leu 
        35                  40                  45              


Tyr Arg Asn Thr Arg Val Gln Thr Arg His Leu Ala Val Asp Pro Met 
    50                  55                  60                  


Thr Pro Glu Phe Gln Glu Phe Ser Ser Arg Pro Ala Thr Val Arg Thr 
65                  70                  75                  80  


Arg Met Asn Asp Tyr Phe His His Ala Val Pro Leu Ala Val Asp Val 
                85                  90                  95      


Ala Arg Arg Ala Leu Ala Gly Val Thr Asp Pro Ala Thr Glu Ile Gly 
            100                 105                 110         


Gln Ile Ile Phe Val Thr Ser Thr Gly Phe Ile Ala Pro Gly Val Asp 
        115                 120                 125             


Val Ala Val Ile Thr Glu Leu Gly Leu Ala Pro Thr Val His Arg Val 
    130                 135                 140                 


Ile Ile Asn Phe Met Gly Cys Ala Ala Ala Ile Asn Gly Ile Ser Thr 
145                 150                 155                 160 


Ala Thr Asp His Val Arg Ala Asn Pro Asp Ser Arg Ala Leu Leu Ile 
                165                 170                 175     


Cys Leu Glu Leu Ser Ser Val Asn Ala Val Phe Gly Ala Asp Pro Val 
            180                 185                 190         


Glu Leu Val Thr His Ser Leu Phe Gly Asp Gly Cys Gly Ala Met Leu 
        195                 200                 205             


Ile Gly Ala Ser Pro Val Gly Arg Arg Leu Ala Pro Gly Gln Leu Val 
    210                 215                 220                 


Val Arg Asp Thr Phe Ser His Leu Phe His Asp Thr Gly Asp Gly Ile 
225                 230                 235                 240 


Val Leu Gly Val Asn Asp Asp Gly Ile Thr Cys Glu Leu Ala Gln Glu 
                245                 250                 255     


Leu Pro Ser Tyr Ile Arg Arg Gly Val Gly Pro Ala Ile Asp Ala Ala 
            260                 265                 270         


Leu Asn Arg Ser Arg Leu Arg Arg Asp Asp Ile Ala His Trp Ala Ile 
        275                 280                 285             


His Pro Gly Gly Pro Ala Ile Ile Glu Gln Ser Val Ala Ala Leu Asp 
    290                 295                 300                 


Leu Pro Pro Asp Arg Ala Ala Thr Ser Trp Glu Val Leu Ala Glu Tyr 
305                 310                 315                 320 


Gly Asn Met Leu Ser Val Ser Leu Val Phe Val Leu Glu Lys Leu Ile 
                325                 330                 335     


Ala Ala Gly Ala His Gly Arg Gly Gln Ala Pro Glu Thr Gly Val Ala 
            340                 345                 350         


Phe Ser Phe Ala Pro Gly Val Ala Leu Glu Gly Met Leu Phe Asp Leu 
        355                 360                 365             


Val Cys 
    370 


<210>  11
<211>  349
<212>  PRT
<213>  Pseudomonas fluorescens Pf5

<400>  11

Met Ser Thr Leu Cys Leu Pro His Val Met Phe Pro Gln His Lys Ile 
1               5                   10                  15      


Thr Gln Gln Gln Met Val Asp His Leu Glu Asn Leu His Ala Asp His 
            20                  25                  30          


Pro Arg Met Ala Leu Ala Lys Arg Met Ile Ala Asn Thr Glu Val Asn 
        35                  40                  45              


Glu Arg His Leu Val Leu Pro Ile Asp Glu Leu Ala Val His Thr Gly 
    50                  55                  60                  


Phe Thr His Arg Ser Ile Val Tyr Glu Arg Glu Ala Arg Gln Met Ser 
65                  70                  75                  80  


Ser Ala Ala Ala Arg Gln Ala Ile Glu Asn Ala Gly Leu Gln Ile Ser 
                85                  90                  95      


Asp Ile Arg Met Val Ile Val Thr Ser Cys Thr Gly Phe Met Met Pro 
            100                 105                 110         


Ser Leu Thr Ala His Leu Ile Asn Asp Leu Ala Leu Pro Thr Ser Thr 
        115                 120                 125             


Val Gln Leu Pro Ile Ala Gln Leu Gly Cys Val Ala Gly Ala Ala Ala 
    130                 135                 140                 


Ile Asn Arg Ala Asn Asp Phe Ala Arg Leu Asp Ala Arg Asn His Val 
145                 150                 155                 160 


Leu Ile Val Ser Leu Glu Phe Ser Ser Leu Cys Tyr Gln Pro Asp Asp 
                165                 170                 175     


Thr Lys Leu His Ala Phe Ile Ser Ala Ala Leu Phe Gly Asp Ala Val 
            180                 185                 190         


Ser Ala Cys Val Leu Arg Ala Asp Asp Gln Ala Gly Gly Phe Lys Ile 
        195                 200                 205             


Lys Lys Thr Glu Ser Tyr Phe Leu Pro Lys Ser Glu His Tyr Ile Lys 
    210                 215                 220                 


Tyr Asp Val Lys Asp Thr Gly Phe His Phe Thr Leu Asp Lys Ala Val 
225                 230                 235                 240 


Met Asn Ser Ile Lys Asp Val Ala Pro Val Met Glu Arg Leu Asn Tyr 
                245                 250                 255     


Glu Ser Phe Glu Gln Asn Cys Ala His Asn Asp Phe Phe Ile Phe His 
            260                 265                 270         


Thr Gly Gly Arg Lys Ile Leu Asp Glu Leu Val Met His Leu Asp Leu 
        275                 280                 285             


Ala Ser Asn Arg Val Ser Gln Ser Arg Ser Ser Leu Ser Glu Ala Gly 
    290                 295                 300                 


Asn Ile Ala Ser Val Val Val Phe Asp Val Leu Lys Arg Gln Phe Asp 
305                 310                 315                 320 


Ser Asn Leu Asn Arg Gly Asp Ile Gly Leu Leu Ala Ala Phe Gly Pro 
                325                 330                 335     


Gly Phe Thr Ala Glu Met Ala Val Gly Glu Trp Thr Ala 
            340                 345                 


<210>  12
<211>  381
<212>  PRT
<213>  Ectocarpus siliculosus

<400>  12

Met Ser Lys Asp Glu Gln Thr Val Tyr Pro Val Ile Ala Gly Met Ala 
1               5                   10                  15      


Ile Gly Asn Pro Gln Tyr Arg Cys Thr Gln Asn Glu Ala Leu Ala Val 
            20                  25                  30          


Ala Ser Lys Cys Pro Gly Leu Glu Ser Ile Lys Pro Val Leu Glu Arg 
        35                  40                  45              


Ile Tyr Gly Asn Ser Arg Ile Gly Ser Arg Tyr Phe Ala Val Pro Asp 
    50                  55                  60                  


Phe Thr Pro Gly Arg Ala Ala Lys Gly Asp Pro Leu Phe Tyr Pro Ala 
65                  70                  75                  80  


Asp Gly Ser Tyr Gln Val Pro Val Asp Val Arg Leu Asp Lys Phe Lys 
                85                  90                  95      


Glu Lys Ala Val Pro Leu Val Ser Asp Val Ala Arg Arg Ala Ile Lys 
            100                 105                 110         


Glu Ala Gly Leu Asn Val Glu Asp Ile Ser Lys Leu Val Val Val Ser 
        115                 120                 125             


Ser Thr Gly Phe Leu Gly Pro Gly Leu Asp Cys Glu Leu Ile Lys Asn 
    130                 135                 140                 


Leu Gly Leu Thr Arg Ser Val Asp Arg Thr Leu Ile Gly Phe Met Gly 
145                 150                 155                 160 


Cys Ala Ala Ala Met Asn Gly Phe Arg Asn Ala Asn Asp Tyr Val Thr 
                165                 170                 175     


Ala Asn Pro Gly Lys Tyr Ala Leu Met Ile Cys Val Glu Leu Ser Ser 
            180                 185                 190         


Val His Thr Thr Phe Asp Asp Asn Ile Asn Asp Ala Ile Leu His Ala 
        195                 200                 205             


Ile Phe Ala Asp Gly Cys Ala Ala Ala Val Leu Lys Gly Ala Arg Lys 
    210                 215                 220                 


Ser Glu Cys Pro Lys Gly Thr Leu Ala Ile Val Asp Asn His Ala Trp 
225                 230                 235                 240 


Leu Met Glu Gly Thr Glu Asp Gly Ile Thr Leu Ala Ile Lys Pro Asn 
                245                 250                 255     


Gly Ile Thr Cys Thr Leu Ser Lys Phe Leu Pro Gln Tyr Ile Ala Lys 
            260                 265                 270         


Asn Ile Ala Phe Phe Ala Asp Gly Phe Leu Lys Lys His Lys Leu Gly 
        275                 280                 285             


Arg Asp Asp Val Asp Phe Trp Cys Val His Pro Gly Gly Arg Arg Ile 
    290                 295                 300                 


Ile Glu Glu Ala Gln Asn Gly Leu Gly Leu Ser Glu Glu Gln Thr Ala 
305                 310                 315                 320 


Asp Ser Trp Ala Val Leu Gly Glu Tyr Gly Asn Met Leu Ser Pro Ser 
                325                 330                 335     


Val Met Phe Val Leu Ser Arg Val Phe Lys Arg His Asn Ala Ala Leu 
            340                 345                 350         


Ala Gln Gly Lys Pro Gly Tyr Gln Thr Gly Met Ala Phe Ser Phe Ser 
        355                 360                 365             


Pro Gly Val Gly Ala Glu Gly Ile Leu Leu Arg Gln Ile 
    370                 375                 380     


<210>  13
<211>  598
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
tatcttaact gatagtttga tcaaaggggc aaaacgtagg ggcaaacaaa cggaaaaatc       60

gtttctcaaa ttttctgatg ccaagaactc taaccagtct tatctaaaaa ttgccttatg      120

atccgtctct ccggttacag cctgtgtaac tgattaatcc tgcctttcta atcaccattc      180

taatgtttta attaagggat tttgtcttca ttaacggctt tcgctcataa aaatgttatg      240

acgttttgcc cgcaggcggg aaaccatcca cttcacgaga ctgatctcct ctgccggaac      300

accgggcatc tccaacttat aagttggaga aataagagaa tttcagattg agagaatgaa      360

aaaaaaaaaa aaaaaaggca gaggagagca tagaaatggg gttcactttt tggtaaagct      420

atagcatgcc tatcacatat aaatagagtg ccagtagcga cttttttcac actcgaaata      480

ctcttactac tgctctcttg ttgtttttat cacttcttgt ttcttcttgg taaatagaat      540

atcaagctac aaaaagcata caatcaacta tcaactatta actatatcgt aatacaca        598


<210>  14
<211>  998
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
aaccagggca aagcaaaata aaagaaactt aatacgttat gccgtaatga agggctacca       60

aaaacgataa tctcaactgt aaacaggtac aatgcggacc cttttgccac aaaacataca      120

tcattcattg ccggaaaaag aaagaagtga agacagcagt gcagccagcc atgttgcgcc      180

aatctaatta tagatgctgg tgccctgagg atgtatctgg agccagccat ggcatcatgc      240

gctaccgccg gatgtaaaat ccgacacgca aaagaaaacc ttcgaggttg cgcacttcgc      300

ccacccatga accacacggt tagtccaaaa ggggcagttc agattccaga tgcgggaatt      360

agcttgctgc caccctcacc tcactaacgc tgcggtgtgc ggatacttca tgctatttat      420

agacgcgcgt gtcggaatca gcacgcgcaa gaaccaaatg ggaaaatcgg aatgggtcca      480

gaactgcttt gagtgctggc tattggcgtc tgatttccgt tttgggaatc ctttgccgcg      540

cgcccctctc aaaactccgc acaagtccca gaaagcggga aagaaataaa acgccaccaa      600

aaaaaaaaat aaaagccaat cctcgaagcg tgggtggtag gccctggatt atcccgtaca      660

agtatttctc aggagtaaaa aaaccgtttg ttttggaatt ccccatttcg cggccaccta      720

cgccgctatc tttgcaacaa ctatctgcga taactcagca aattttgcat attcgtgttg      780

cagtattgcg ataatgggag tcttacttcc aacataacgg cagaaagaaa tgtgagaaaa      840

ttttgcatcc tttgcctccg ttcaagtata taaagtcggc atgcttgata atctttcttt      900

ccatcctaca ttgttctaat tattcttatt ctcctttatt ctttcctaac ataccaagaa      960

attaatcttc tgtcattcgc ttaaacacta tatcaata                              998


<210>  15
<211>  300
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
gaagttttgt tagaaaataa atcatttttt aattgagcat tcttattcct attttattta       60

aatagtttta tgtattgtta gctacataca acagtttaaa tcaaattttc tttttcccaa      120

gtccaaaatg gaggtttatt ttgatgaccc gcatgcgatt atgttttgaa agtataagac      180

tacatacatg tacatatatt taaacatgta aacccgtcca ttatattgct tactttcttc      240

ttttttgccg ttttgacttg gacctctggt ttgctatttc cttacaatct ttgctacaat      300


